An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Desmodium heterocarpon; flavonoids; glucosides; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... A new 2-carboxy-dihydrostilbene glucoside, 2-carboxy-3,5,4′-trihydroxydihydrostilbene 3-O-β-d-glucopyranoside (1) and a new flavan diglycoside, (2S)-5,7,4′-trihydroxyflavan 7-O-β-d-apiofuranosyl-(1→6)-O-β-d-glucopyranoside (3) were isolated from the aerial portion of Thai origin Desmodium heterocarpon together with five known compounds, lunularic acid 4′-O-β-d-glucopyranoside (2), vitexin (4), iso ...
... The present study aimed at the phytochemical and pharmacological investigation of Sideritis montana L. (Lamiaceae). Two new abietane diterpenes [sideritins A (1) and B (2)] were isolated from the methanol extract of the plant. Six known compounds [pomiferin E (3), 9α,13α-epi-dioxyabiet-8(14)-en-18-ol (4), paulownin (5), 6-methoxysakuranetin (6), 3-oxo-α-ionol (7) and 4-allyl-2,6-dimethoxyphenol gl ...
Dipterocarpaceae; chemical composition; glucosides; leaves; nuclear magnetic resonance spectroscopy; resveratrol; spectral analysis
Abstract:
... A comprehensive investigation of the chemical constituents of the leaves of Upuna borneensis (Dipterocarpaceae) was performed. Three new glucosides of resveratrol oligomers having a pentameric aglycone [upunoside E (1)] and dimeric aglycones [upunosides F (3) and G (4)], as well as 14 resveratrol derivatives (2, 5–17), were isolated. The absolute configurations of the new compounds were elucidated ...
... As evidence mounts for a health-protective role of dietary phenolics, the importance of understanding factors influencing bioavailability increases. Recent evidence has suggested chronic exposure to phenolics may impact their absorption and metabolism. To explore alterations occurring from chronic dietary exposure to phenolics, Caco-2 cell monolayers were differentiated on Transwell inserts with 0 ...
... Benzoxazinoids are highly studied compounds due to their biological activity and presence in several cereals. They include compound classes such as hydroxamic acids and lactams and usually occur as inactive glucosides in unstressed plants. Injury to the plant causes enzymatic hydrolysis of the inactive glucosides to the biologically active hydroxamic acid and lactam aglucones. The hydroxamic acids ...
Aspalathus linearis; chemical composition; ecotypes; glucosides; mass spectrometry; phenolic compounds; phloridzin; tea
Abstract:
... Tea samples from 17 populations of “wild tea” ecotypes Aspalathus linearis (rooibos tea) and 2 populations of Aspalathus pendula were analyzed. Recent advances in column technology together with high-resolution mass spectrometry were applied to improve resolution, facilitating the identification of several new compounds as well as grouping of the wild tea ecotypes according to their chemical compo ...
... Chemical investigation of the rhizomes of Helminthostachys zeylanica led to the isolation of eight new flavonoids including six cyclized geranylflavonoids, ugonins V–X (1–3), (10R,11S)-ugonin N (4), (10R,11S)-ugonin S (5), and ugonin Y (6), as well as two quercetin glucosides, quercetin-4′-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside (7) and quercetin-3-O-β-d-glucopyranosyl-4′-O-β-d-glucopyranos ...
... The present study describes the screening of eight herbs namely Cosmos caudatus, Pluchea indica, Lawsonia inermis, Carica papaya, Piper betle, Andrographis paniculata, Pereskia bleo , and Melicope lunu based on their anti-obesity and antioxidant activities. Out of all tested herbs, Cosmos caudatus demonstrated excellent anti-obesity and antioxidant potential with pancreatic lipase inhibitory effec ...
... Plants belonging to the genus Rumex (family Polygonaceae) are used worldwide in traditional medicine for the treatment of various diseases caused by different microorganisms (e.g. bacteria-related dermatologic conditions, dysentery and enteritis). The present study focused on the antibacterial screening of Rumex species native to the Carpathian Basin, and isolation of compounds from one of the mos ...
... Phytochemical investigations of Quercus incana led to the isolation of a new catechin derivative quercuschin (1), along with six known compounds: quercetin (2), methyl gallate (3), gallic acid (4), betulinic acid (5), (Z)-9-octadecenoic acid methyl ester (6) and β-sitosterol glucoside (7) from the ethyl acetate fraction of methanolic extract of the bark. Compound 1 was screened for its antibacteri ...
... The polyphenolic‐rich extract of Tunisian Origanum glandulosum Desf. was investigated for its phenolic composition, antioxidant activity and potential to contribute to the dietary management of type II diabetes. By mean of an ultra‐performance liquid chromatography‐electrospray ionization‐ mass spectrometry (UPLC‐PDA‐ESI‐MS) 16 phenolics were characterized. The major detected compounds are caffeic ...
... The crude acetonic extract of broad bean seeds was separated into fraction I (low-molecular-weight compounds) and fraction II (tannin fraction) using Sephadex LH-20 column chromatography with ethanol and acetone/water (1:1, v/v) as the mobile phases. Phenolics present in the crude extract and fractions thereof showed antioxidant and radical-scavenging properties determined using several methods (e ...
... In the search for biologically active compounds from the roots of Bupleurum chinense D C., phytochemical investigation of its ethanol extract led to the isolation and identification of a new 8- O -4′ neolignan glucoside, saikolignanoside A (1), along with eight known lignans (2–9). Their structures were determined on the basis of IR, UV, HRESIMS, and NMR spectroscopic analyses. The antioxidant and ...
... Maintaining a strong antioxidant system is essential for preventing drought-induced oxidative stress. Thus, in the present study we investigated the role of some non-enzymic and enzymic antioxidants in desiccation tolerance of Haberlea rhodopensis. The effects of high light upon desiccation on antioxidant capacity was estimated by comparing the response of shade and sun plants. The significant enh ...
Olivia Jansen; Alembert T. Tchinda; Jean Loua; Virginie Esters; Ewa Cieckiewicz; Allison Ledoux; Paul D. Toukam; Luc Angenot; Monique Tits; Aliou M. Balde; Michel Frédérich
Plasmodium falciparum; active ingredients; antimalarials; antiparasitic properties; beta-sitosterol; concrete; diterpenoids; ethanol; evaporation; fractionation; gallic acid; gel chromatography; glucosides; herbal medicines; human cell lines; inhibitory concentration 50; kaempferol; lactate dehydrogenase; leaf extracts; leaves; malaria; parasites; quercetin; resveratrol; spectroscopy; traditional medicine; Guinea
Abstract:
... Decoctions of the leaves of M. benthamianum Baill. are used by traditional healers in Guinea to treat malaria and this use was validated by a preliminary clinical assay.To evaluate the in vitro antiplasmodial activity and to identify active compounds from extracts of M. benthamianum leaves.Antiplasmodial activity of extracts, fractions and pure compounds was evaluated in vitro against a chloroquin ...
... The bioactive petroleum ether fraction of Verbesina encelioides , previously studied by the authors, was chosen for the isolation of antiprotozoal metabolites. Pseudotaraxasterol-3β-acetate (1), benzyl 2,6-dimethoxy benzoate (2), 16β-hydroxy-pseudotaraxasterol-3β-palmitate (3) and pseudotaraxasterol (4), in addition to β -sitosterol glucoside (5) and β -sitosterol galactoside (6) were isolated and ...
Iris (Iridaceae); chemical derivatives; chemical structure; glucosides; rhizomes; spectral analysis
Abstract:
... Phytochemical investigation of the rhizomes of Iris tectorum resulted in the isolation and characterization of three new apocynin derivatives, apocynin-4-O- β -D-(6′-O-syringyl)glucopyranoside (1), scrophenoside C-7-ethyl ether (2 , 3), together with a new naturally occurring compound but known by synthesis, apocynin-4-O- β -D-xylopyranoside (4), and five known ones (5–9). Their structures were el ...
... The major aroma components in grapes and wine include free volatile compounds and glycosidic nonvolatile compounds. The latter group of compounds is more than 10 times abundant of the former, and constitutes a big aroma reserve in grapes and wine. This review summarizes the research results obtained recently for the identification of aroma glycosides in grapes and wine, including grape glycoside s ...
Citrus deliciosa; Citrus paradisi; Citrus sinensis; adulterated products; commodity foods; fruit juices; glucosides; grapefruits; hesperidin; horticultural crops; limonin; liquid chromatography; mandarins; metabolomics; naringin; tandem mass spectrometry; India
Abstract:
... Citrus fruits are one of the most important horticultural crops grown India, and a food commodity that is often targeted for mislabeling worldwide. Authentic citrus fruit samples (Kinnow mandrain (citrus nobilis x Citrus deliciosa), Jaffa and Mosambi orange (Citrus sinensis), and Red blush grapefruit (Citrus paradisi)) were obtained from the Indian Agriculture Research Institute and analysed by an ...
... Two pairs of rare benzofuran glucoside epimers, indicuses A and B and indicuses C and D, three biogenetically related compounds indicuses E–G, and one coumarin indicus H, as well as 11 known compounds, were isolated from the bark of Streblus indicus (Bur.) Corner. The structures of indicuses A–H were elucidated by NMR and MS data, as well as by CD. (S)-Marmesinin exhibited moderate antimicrobial a ...
Litsea cubeba; X-ray diffraction; air drying; branches; circular dichroism spectroscopy; glucosides; human cell lines; inhibitory concentration 50; lignans; medicinal plants; nuclear magnetic resonance spectroscopy
Abstract:
... The air-dried twigs of Litsea cubeba, a traditional Chinese medicinal tree, afforded 10 new aromatic glycosides (1–10) and 26 known analogues. Their structures were assigned by extensive 1D and 2D NMR experiments, and the absolute configurations were resolved by chemical methods, electronic circular dichroism, specific rotation, and X-ray crystallographic analysis. Compound 4 is the first example ...
... A callus culture of Lactuca aculeata, except for commonly distributed caffeic acid derivatives typically found in the Asteraceae family (chlorogenic acid, methyl caffeate, 1,5- dicaffeoylquinic acid), yielded bioactive lignans: (+)-5-methoxybalanophonin, syringaresinol, (+)-balanophonin-9-O-β-glucopyranoside, (+) buddlenol A, (−)-dihydrodehydrodiconiferyl alcohol-4-O-β-glucopyranoside and (−)-dihy ...
... A new steroid glucoside (1), along with nine known steroids (2–10) and four known sorbicillinoids (11–14), were isolated from the endophytic fungus Trichoderma sp. Xy24. Their structures were elucidated on the basis of spectroscopic data analyses and by comparison with reported data. Compounds 3 , 5–7 , 9 , 10 , and 13 exhibited significant inhibitory effects on HIV-1 virus with IC ₅₀ values rangi ...
Capsicum frutescens; biochemical pathways; bioengineering; biolistics; biotechnology; callus; consumer demand; explants; ferulic acid; genes; glucosides; high performance liquid chromatography; hot peppers; plant cultural practices; polymerase chain reaction; vanilla beans; vanillin
Abstract:
... Production of vanillin by bioengineering has gained popularity due to consumer demand toward vanillin produced by biological systems. Natural vanillin from vanilla beans is very expensive to produce compared to its synthetic counterpart. Current bioengineering works mainly involve microbial biotechnology. Therefore, alternative means to the current approaches are constantly being explored. This wo ...
... Steviol glucosides (SGs) such as rubusoside (Ru), stevioside (Ste), rebaudioside A (RebA) and stevioside glucosides (SG) are herbal tea sweeteners that enhance the solubility and stability of a number of pharmaceutically important compounds. The complex of epigallocatechin gallate (EGCG) with 10% (w/v) each Ru, Ste, RebA or SG enhanced the water solubility of EGCG over 15 times to 345, 312, 341, o ...
... Soy whey is a liquid waste stream generated from tofu and soy protein manufacturing, and is commonly disposed of into the drainage system in food industry. Instead of disposing of soy whey as a waste, it could be used to produce alcoholic beverages. This study investigated the feasibility of converting soy whey into soy alcoholic beverage using four commercial Saccharomyces cerevisiae strains as a ...
... The vast diversity and membrane-bound nature of plant P450s makes it challenging to study the structural characteristics of this class of enzymes especially with respect to accurate intermolecular enzyme-substrate interactions. To address this problem we here apply a modified hybrid structure strategy for homology modeling of plant P450s. This allows for structural elucidation based on conserved m ...
... Oxidative stress and autophagy dysfunction are critical factors in the pathogenesis of atherosclerosis. Adenosine 5′ monophosphate-activated protein kinase (AMPK) plays an important role in inhibiting oxidative stress and promoting autophagy. Catalpol, an iridoid glucoside extracted from the root of Rehmanniae glutinosa L, was reported to produce a potent antioxidant effect. However, the mechanism ...
... Previously, we have shown that the glucansucrase GtfA-ΔN enzyme of Lactobacillus reuteri 121, incubated with sucrose, efficiently glucosylated catechol and we structurally characterized catechol glucosides with up to five glucosyl units attached (te Poele et al. in Bioconjug Chem 27:937–946, 2016). In the present study, we observed that upon prolonged incubation of GtfA-ΔN with 50 mM catechol and ...
... Condensed tannins from larch bark extracts are a natural renewable and eco-friendly material and are potential substitutes for phenolic petrochemicals. However, the wide application of tannin is restricted by its low reactivity. Therefore, the goal of this study was to enhance the reactivity of larch tannin by depolymerization and determine optimal reaction conditions. The structures of larch tann ...
... The flavonoid content in leaves of Zostera marina and the endangered Zostera noltii, including mono- and disulphated flavonoids, from different sample localities were characterized. Seasonal variation of both individual and total flavonoid, as well as rosmarinic acid concentration were revealed. Minor amounts of luteolin 7-(6″-malonyl)glucoside (6) and apigenin7-(6″-malonyl)glucoside (11) were ide ...
... Microbial exopolysaccharides (EPSs) have been commercially used for decades owing to their distinct rheological properties. New EPSs with special traits are being explored continuously. The strain Paenibacillus edaphicus NUST16 was isolated in this study. NUST16 produces 12.5g/L EPS after 72h cultivation in shaker flask. Moreover, the purified EPS, POS16, has the molecular weight of 1.2×107Da and ...
... The objective of this research was to access the determination of metabolite profiles and antioxidant properties in the leaves of green perilla (Perilla frutescens), where these are considered functional and nutraceutical substances in Korea. A total of 25 compositions were confirmed as six phenolic acids, two triterpenoids, eight flavonoids, seven fatty acids, and two glucosides using an ultra hi ...
Lactuca sativa; apigenin; cultivars; diodes; freeze drying; glucosides; health promotion; ionization; ions; lettuce; mass spectrometry; polyphenols; ultra-performance liquid chromatography
Abstract:
... Lettuce (Lactuca sativa) is one of the most popular leafy vegetables in the world and constitutes a major dietary source of phenolic compounds with health‐promoting properties. In particular, the demand for green and red oak‐leaf lettuces has considerably increased in the last years but few data on their polyphenol composition are available. Moreover, the usage of analytical edge technology can pr ...
... Sesame (Sesamum indicum, L.) seed oil was characterized for quality characteristics, phenolic composition and was supplemented to rabbits in different doses to assess potential beneficial effects. The phenolic profile of the oil was studied using reversed phase HPLC-DAD method. Sesame oil was rich in total phenolic contents, flavonoids, pigments and possess strong antioxidant activity. The HPLC-DA ...
2,2-diphenyl-1-picrylhydrazyl; acetone; anthocyanins; antioxidant activity; color; cultivars; glucosides; lipid peroxidation; liquid chromatography; mass spectrometry; rice; temperate zones; India
Abstract:
... The purpose of the research was to identify the phenolic and flavonoid compounds of seven different traditional pigmented whole rice cultivars grown in the temperate regions of Kashmir so as to study their relationship with in vitro antioxidant capacities. The completely pigmented rice cultivars were found to have higher phenolic, flavonoid, anthocyanin contents and exhibited higher antioxidant ca ...
... The purpose of this work was to determine the chemical profile of stinging nettle and to provide an insight into the mechanisms by which it ameliorates the immune response. Qualitative and quantitative liquid chromatography tandem mass spectrometry analyses indicated that phenolic acids (5‐O‐caffeoylquinic acid as dominant) and flavonol glycosides (rutin, isoquercitrin, and kaempferol 3‐O‐glucosid ...
Leonurus sibiricus; acetylcholinesterase; aerial parts; alkaloids; beta-sitosterol; chemical composition; diterpenoids; glucosides; hydrochloric acid; maceration; methanol; traditional medicine; Brazil
Abstract:
... Chemical investigation of the aerial parts of Leonurus sibiricus L. used in Brazilian folk medicine led to the identification of the following constituents: the labdane-type diterpenoid leojaponin, the phytosterols β-sitosterol and β-sitosterol glucoside and the alkaloid leonurine. The crude extracts obtained from methanol and methanol/1% HCl and pure compounds isolated from L. sibirius were inves ...
Francisco LesThese authors equally contributed to the article.; Víctor López; Giovanni Caprioli; Romilde Iannarelli; Dennis Fiorini; Marzia Innocenti; Maria Bellumori; Filippo Maggi
Cotoneaster; alpha-glucosidase; amine oxidase (flavin-containing); antioxidant activity; ascorbic acid; beta-carotene; chlorogenic acid; color; dietary supplements; fruit extracts; fruits; functional foods; glucosides; high performance liquid chromatography; ingredients; ornamental plants; shikimic acid; shrubs; tandem mass spectrometry; China
Abstract:
... Cotoneaster pannosus (Rosaceae) is a semievergreen shrub, producing globose dark red pomes, native to China and widely used as an ornamental plant all over the world. Despite its extensive cultivation, little information is available on the chemical composition and biological activities of its fruits. In this work, the analysis of the chemical composition of C. pannosus fruits, in terms of phenoli ...
... Ten new clerodane diterpenoid glucosides (1–10) and three known analogues (11–13) were isolated from an EtOAc extract of the stems of Tinospora sinensis. Spectroscopic analyses and chemical methods were used to elucidate the structures of these isolates. The absolute configurations of tinosinenosides A–C (1–3) were established by using experimental and calculated ECD data. Their cytotoxicity again ...
... The present study aimed to use a chemometric study to compare the in-vitro antioxidant activities and bioactive compounds of flaxseed based on the variety and geographical origins, and further explore the specific components constructed the endogenous antioxidant system of flaxseed in China. The differential contents of α-linolenic acid (35.83–58.91%), lignans (11.37–33.31 mg/g), total phenolic ac ...
... Use of the immunosuppressant mycophenolic acid (MPA) in cats is limited because MPA elimination depends on glucuronidation, which is deficient in cats. We evaluated formation of major (phenol glucuronide) and minor (acyl glucuronide, phenol glucoside, and acyl glucoside) MPA metabolites using liver microsomes from 16 cats, 26 dogs, and 48 humans. All MPA metabolites were formed by human liver micr ...
... Of numerous species belonging to the medicinally important genus Hypericum, only H. perforatum L. and H. maculatum Crantz grow widely in Estonia. A comparative biochemical systematics study of hypericins, hyperforins and other phenolics within Hypericum spp. growing in Estonia was performed. For comprehensive metabolomic investigation, 42 samples of H. perforatum and 16 samples of aerial parts of ...
... Stevia rebaudiana is beneficial to treat diabetes because of its low-calorie glucoside sweeteners. Natural and vegetative propagation are inefficient. In vitro techniques are an attractive alternative but low propagation and reproducibility rates have been reported. Therefore, different ways to increase natural sweetener production in vitro, such as BIT®, are required. We compared semisolid medium ...
... Senna is an important medicinal plant and is used in many Ayurvedic formulations. Dianthraquinone glucosides are the main bioactive phytochemicals present in leaves and pods of senna. The extraction efficiency in terms of yield and composition of the extract of senna prepared using both conventional (cold percolation at room temperature and refluxing) and non conventional (ultrasound and microwave ...
... An iridoid glucoside, 10-p-hydroxybenzoyl-6β-hydroxyiridoid 1-O-β-D-(6′-O-p-hydroxybenzoyl)-glucopyranoside (1), and a phenol glucoside, 4-hydroxyphenethanol 3-O-β-D-(6′-O-p-hydroxybenzoyl)-glucopyranoside (2), along with nine known compounds (3–11) were isolated from the dried leaves of Vitex negundo var. heterophylla. Their structures were elucidated by extensive analysis of NMR spectra. All of ...
... The acclimation mechanisms of two berry color variant grapevine leaves, Furmint White (FW) and Furmint Red (FR), to natural sunlight conditions were investigated comparing leaves from two distinct locations: at canopy surface (sun-exposed leaves) and in the inner layers (shaded leaves). We found that in contrast to FR leaves, sun-exposed FW leaves were thicker than shaded leaves due to thicker pal ...
Cornus officinalis; chemical structure; fruits; glucosides; human cell lines; inhibitory concentration 50; iridoid glycosides; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Fifteen new and rare iridoid glucoside dimers, cornusides A–O (1–15), and 10 known iridoid glucosides (16–25) were isolated from the fruit of Cornus officinalis. These new chemical structures were established through spectroscopic analysis (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1–25 were tested for their inhibitory activities by measuring IL-6-induced STAT3 promoter activity in HepG2 cells, a ...
... Due to an unfortunate turn of events, the funding note for Open Access publication was not properly provided in the original publication. Hence, the original article has been corrected. The opening line of the Acknowledgement section should read: ...
Siraitia grosvenorii; glucosides; luciferase; nuclear magnetic resonance spectroscopy
Abstract:
... Seven new cucurbitane glucosides, 11-oxomogrosides III E and IV (1 and 2), 11-oxoisomogroside V (3), 7-oxomogrosides III E and IV (4 and 5), and mogrosides VI A and VI B (6 and 7), were separated from the crude extract of Siraitia grosvenorii. The new structures were defined by analysis of their ¹H and ¹³C NMR, 2D NMR, and HRESIMS data. Especially, the band-selective constant time HSQC and band-se ...