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You searched for: Publication year rev 7983-2017 Remove constraint Publication year rev: 7983-2017 Subject lignans Remove constraint Subject: lignans Subject spectral analysis Remove constraint Subject: spectral analysis Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Alashinols F and G, two lignans from stem bark of Syringa pinnatifolia

Author:
Xiao Feng; Guozhu Su; Yunyun Ye; Ruifei Zhang; Xinyao Yang; Bingzhao Du; Bing Peng; Pengfei Tu; Xingyun Chai
Source:
Natural product research 2017 v.31 no.13 pp. 1555-1560
ISSN:
1478-6427
Subject:
Syringa; anti-inflammatory activity; bark; lignans; nuclear magnetic resonance spectroscopy; spectral analysis; traditional medicine
Abstract:
... Two new lignans, alashinols F and G (1 and 2), together with two known analogues (−)-secoisolariciresinol (3) and meso -secoisolariciresinol (4) were isolated from the stem bark of Syringa pinnatifolia , a Mongolian folk medicine with anti-myocardial ischaemic effects. Their structures were elucidated on basis of spectroscopic data analyses, including MS and 1D and 2D NMR, and their absolute confi ...
DOI:
10.1080/14786419.2017.1283500

2. Antibacterial neolignans from the leaves of Melaleuca bracteata

Author:
Can Li; Hongxin Liu; Liyun Zhao; Weimin Zhang; Shengxiang Qiu; Xiaoyun Yang; Haibo Tan
Source:
Fitoterapia 2017 v.120 pp. 171-176
ISSN:
0367-326X
Subject:
Melaleuca; aldehydes; antibiotic resistance; antimicrobial properties; biochemical pathways; biomimetics; leaves; lignans; methicillin; methicillin-resistant Staphylococcus aureus; odors; spectral analysis
Abstract:
... Phytochemical study on the leaves of Melaleuca bracteata resulted in the isolation of ten compounds including three new neolignans, named melaleucins A–C (1–3). Among them, melaleucin B shares a rarely occurring nor-neolignan skeleton, and both melaleucins B and C bear a novel aldehyde moiety, which might also be response for the delicate fragrance of M. bracteata. Their structures were extensivel ...
DOI:
10.1016/j.fitote.2017.06.015

3. Antioxidant and cytotoxic lignans from the roots of Bupleurum chinense

Author:
Dan-Qi Li; Di Wang; Le Zhou; Ling-Zhi Li; Qing-Bo Liu; Ying-Ying Wu; Jing-Yu Yang; Shao-Jiang Song; Chun-Fu Wu
Source:
Journal of Asian natural products research 2017 v.19 no.5 pp. 519-527
ISSN:
1477-2213
Subject:
2,2-diphenyl-1-picrylhydrazyl; Bupleurum chinense; antioxidant activity; bioactive compounds; cytotoxicity; ethanol; fluorouracil; free radical scavengers; glucosides; inhibitory concentration 50; lignans; neoplasm cells; nuclear magnetic resonance spectroscopy; roots; spectral analysis
Abstract:
... In the search for biologically active compounds from the roots of Bupleurum chinense D C., phytochemical investigation of its ethanol extract led to the isolation and identification of a new 8- O -4′ neolignan glucoside, saikolignanoside A (1), along with eight known lignans (2–9). Their structures were determined on the basis of IR, UV, HRESIMS, and NMR spectroscopic analyses. The antioxidant and ...
DOI:
10.1080/10286020.2016.1234456

4. Antiplasmodial Securinega alkaloids from Phyllanthus fraternus: Discovery of natural (+)-allonorsecurinine

Author:
Gustav Komlaga; Grégory Genta-Jouve; Sandrine Cojean; Rita A. Dickson; Merlin L.K. Mensah; Philippe M. Loiseau; Pierre Champy; Mehdi A. Beniddir
Source:
Tetrahedron letters 2017 pp. -
ISSN:
0040-4039
Subject:
Phyllanthus fraternus; Plasmodium falciparum; Securinega; alkaloids; antimalarials; antiparasitic properties; chemical reactions; chemical structure; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... The chemical investigation of the antimalarial plant Phyllanthus fraternus G. L. Webster (Phyllanthaceae) resulted in the discovery of the Securinega alkaloid (+)-allonorsecurinine (1), previously reported as a synthetic compound, together with the known ent-norsecurinine (2), nirurine (3), bubbialine (4), epibubbialine (5) and the lignan phyllanthin (6). The structure and absolute configuration o ...
DOI:
10.1016/j.tetlet.2017.08.045

5. Bioactive Asarone-Derived Phenylpropanoids from the Rhizome of Acorus tatarinowii Schott

Author:
Gao En; Zhou Zheng-Qun; Zou Jian; Yu Yang; Feng Xiao-Lin; Chen Guo-Dong; He Rong-Rong; Yao Xin-Sheng; Gao Hao
Source:
Journal of natural products 2017 v.80 no.11 pp. 2923-2929
ISSN:
1520-6025
Subject:
2,2-diphenyl-1-picrylhydrazyl; Acorus gramineus; acarbose; acetylcholinesterase; alpha-glucosidase; antioxidant activity; antioxidants; benzene; drugs; enantiomers; enzyme inhibition; high performance liquid chromatography; inhibitory concentration 50; lignans; phenylpropanoids; rhizomes; spectral analysis
Abstract:
... Eight new (1a/1b, 2a, 3a, 4a/4b, and 5a/5b) and seven known (2b, 3b, and 6–10) asarone-derived phenylpropanoids, a known asarone-derived lignan (12), and four known lignan analogues (11 and 13–15) were isolated from the rhizome of Acorus tatarinowii Schott. The structures were elucidated via comprehensive spectroscopic analyses, modified Mosher’s method, and quantum chemical calculations. Compound ...
DOI:
10.1021/acs.jnatprod.7b00457

6. Chemical constituents from Piper boehmeriifolium (Miq.) Wall. ex C. DC

Author:
Tie Liu; Qian Liang; Xin-Min Zhang; Gen-Qian Li; Bo Xu; Wen-Hui Xu
Source:
Biochemical systematics and ecology 2017 v.75 pp. 27-30
ISSN:
0305-1978
Subject:
Piper; alkaloids; chemical composition; chemotaxonomy; diterpenoids; lignans; monoterpenoids; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... The chemical investigation of whole plants Piper boehmeriifolium (Miq.) Wall. ex C. DC. led to the isolation of 22 compounds, including two lignans (1–2), sixteen amide alkaloids (3–18), one diterpene (19), two monoterpenes (20–21), and one phenylpropanoid (22). Their structures were elucidated by extensive spectroscopic analyses including NMR, MS, and by comparison with the literature. Compounds ...
DOI:
10.1016/j.bse.2017.11.003

7. Configuration and stability of naturally occurring all-cis-tetrahydrofuran lignans from Piper solmsianum

Author:
Clécio S. Ramos; Harrald V. Linnert; Marcilio M. de Moraes; João H. do Amaral; Lydia F. Yamaguchi; Massuo J. Kato
Source:
RSC advances 2017 v.7 no.74 pp. 46932-46937
ISSN:
2046-2069
Subject:
Piper; density functional theory; hydrogen bonding; isomers; leaves; lignans; nuclear magnetic resonance spectroscopy; spectral analysis; tetrahydrofuran
Abstract:
... The study of variability of the tetrahydrofuran lignan (−)-grandisin in leaves of Piper solmsianum (Piperaceae) revealed two unknown compounds, that were isolated and determined to be the all-cis tetrahydrofuran lignans 1a [rel-(7R,8S,7′S,8′R)-3,4,5,3′,4′,5′-hexamethoxy-7,7′-epoxylignan] and 1b [rel-(7R,8S,7′S,8R′)-3′,4′-methylenedioxy-3,4,5,5′-tetramethoxy-7,7′-epoxylignan]. Their structures were ...
DOI:
10.1039/c7ra09262h

8. Cytotoxic neolignans from the traditional Chinese medicine Daphniphyllum macropodum Miq.

Author:
Xinhua Ma; Jie Yang; Christopher L. Brown; Chao Wang; Shihao Deng; Ruifang Ke; Shicheng Xu; Mi Huang; Xinzhou Yang; Yunjiang Feng
Source:
RSC advances 2017 v.7 no.83 pp. 52970-52976
ISSN:
2046-2069
Subject:
Daphniphyllum; Oriental traditional medicine; apoptosis; benzaldehyde; caspase-3; caspase-9; cell growth; cell lines; circular dichroism spectroscopy; cytotoxicity; dose response; humans; lignans; mitochondria; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; seeds; spectral analysis
Abstract:
... Four new neolignans, (E)-3-(hydroxymethyl)-2-(4-hydroxyphenyl)-5-(prop-1-en-1-yl)benzofuran-6-ol (1), methyl (E)-6-hydroxy-2-(4-hydroxyphenyl)-5-(prop-1-en-1-yl)benzofuran-3-carboxylate (2), (R)-4-hydroxy-3-(1-(4-hydroxyphenyl)propan-2-yl)benzaldehyde (3) and methyl (E,R)-3-(4-hydroxy-3-(1-(4-hydroxyphenyl)propan-2-yl)phenyl)acrylate (4) were isolated from the seeds of Daphniphyllum macropodum Miq ...
DOI:
10.1039/c7ra09569d

9. Diacylglycerol acyltransferase 1 (DGAT1) inhibition by furofuran lignans from stems of Acanthopanax senticosus

Author:
Ban-Ban Li; Jia-Lin Li; Na Li; Shi-Zhou Qi; Hyun-Sun Lee; Le Zhang; Shan-Shan Xing; Zhen-Dong Tuo; Long Cui
Source:
Archives of pharmacal research 2017 v.40 no.11 pp. 1271-1277
ISSN:
0253-6269
Subject:
Eleutherococcus senticosus; diacylglycerol acyltransferase; inhibitory concentration 50; lignans; spectral analysis; stems
Abstract:
... Two new furofuran lignans were isolated from the stems of Acanthopanax senticosus, along with seven known compounds. Their structures were all determined by spectroscopic analyses and chemical methods. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Compounds 1 and 2 were found to exhibit selective inhibitory activity on DGAT1 with IC₅₀ values 89.5 ± 1.5 a ...
DOI:
10.1007/s12272-016-0842-5

10. Diarylpropanes and lignans from Horsfieldia tetratepala

Author:
Shou-Zhen Du; Zhi-Chong Wang; Ying Liu; Rui Zhan; Ye-Gao Chen
Source:
Phytochemistry letters 2017 v.19 pp. 98-100
ISSN:
1874-3900
Subject:
acetone; branches; cytotoxicity; lignans; neoplasms; spectral analysis
Abstract:
... Two new diarylpropanes (1–2), four known compounds, and a new artifact, were isolated from 70% aqueous acetone extract of the twigs of Horsfieldia tetratepala. Their structures were elucidated by spectroscopic analysis. Cytotoxicity evaluation against five cancer cell lines showed that none of these compounds was cytotoxic. ...
DOI:
10.1016/j.phytol.2016.12.018

11. Enantiomeric 8-O-4′ type neolignans from red raspberry as potential inhibitors of β-amyloid aggregation

Author:
Le Zhou; Li-Li Lou; Wei Wang; Bin Lin; Jun-Ning Chen; Xiao-Bo Wang; Xiao-Xiao Huang; Shao-Jiang Song
Source:
Journal of functional foods 2017 v.37 pp. 322-329
ISSN:
1756-4646
Subject:
Alzheimer disease; Rubus idaeus; chemical composition; chemical structure; functional foods; lignans; neuroprotective effect; spectral analysis; stereochemistry
Abstract:
... Red raspberry (Rubus idaeus L.) is an edible fruit-producing species belonging to the Rosaceae family. In our search for potential agents for treating Alzheimer’s disease in this functional food, we decided to investigate the chemical constituents of red raspberry. Four pairs of enantiomeric 8-O-4′-type neolignans (1a/1b–4a/4b), including three new compounds (1a/1b and 2a), were identified from th ...
DOI:
10.1016/j.jff.2017.08.007

12. Flavonol glycosides and lignans from the leaves of Opilia amentacea

Author:
Abdulmagid Alabdul Magid; Anaëlle Abdellah; Virginie Pecher; Laure Pasquier; Dominique Harakat; Laurence Voutquenne-Nazabadioko
Source:
Phytochemistry letters 2017 v.21 pp. 84-89
ISSN:
1874-3900
Subject:
2,2-diphenyl-1-picrylhydrazyl; Opiliaceae; antioxidant activity; flavonols; glycosides; inhibitory concentration 50; leaves; lignans; mushrooms; spectral analysis
Abstract:
... Two previously undescribed flavonol tetraglycosides, isorhamnetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (1) and isorhamnetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside (2), along with nine known compounds including seven flavonoids and two lignans, were isolated from the l ...
DOI:
10.1016/j.phytol.2017.05.023

13. Furofuran lignan glucosides from the leaves of Vitex negundo var. cannabifolia

Author:
Yue-Ting Li; Man-Man Li; Jing Sun; Zhi-Xiang Zhu; Yue-Lin Song; Dao-Ran Pang; Jiao Zheng; Yun-Fang Zhao; Peng-Fei Tu; Jun Li
Source:
Natural product research 2017 v.31 no.8 pp. 918-924
ISSN:
1478-6427
Subject:
Vitex negundo; glucosides; inhibitory concentration 50; leaves; lignans; nitric oxide; spectral analysis; spectroscopy
Abstract:
... Two new furofuran lignan glucosides, cannabilignin (1) and isocannabilignin (2), together with four known compounds (3 – 6), were isolated from the leaves of Vitex negundo var. cannabifolia . The structures of the isolates were elucidated by analysis of spectroscopic data. Compound 3 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC ...
DOI:
10.1080/14786419.2016.1255887

14. Hepatoprotective triterpenoids and lignans from the stems of Schisandra pubescens

Author:
Guo-Wei Wang; Li-Qing Deng; You-Ping Luo; Zhi-Hua Liao; Min Chen
Source:
Natural product research 2017 v.31 no.16 pp. 1855-1860
ISSN:
1478-6427
Subject:
Schisandra; hepatoprotective effect; lignans; nuclear magnetic resonance spectroscopy; spectral analysis; stems; survival rate; triterpenoids
Abstract:
... One new triterpenoid (1) and 13 known compounds (2–14) were isolated from Schisandra pubescens stems. The structure of the new compound was established on the basis of 1D/2D NMR and HRESIMS spectroscopic analyses. The isolated compounds were evaluated for their hepatoprotective activities against D-GalN-induced cell injury in QSG7701 cells. Compounds 1, 13 and 14 at 10 μM showed hepatoprotective a ...
DOI:
10.1080/14786419.2016.1261348

15. Lignan glycosides from the Rhizomes of Smilax trinervula and their Biological activities

Author:
Jicheng Shu; Fang Liang; Genhua Zhu; Xing Liu; Jiangli Yu; Huilian Huang
Source:
Phytochemistry letters 2017 v.20 pp. 1-8
ISSN:
1874-3900
Subject:
Smilax; cytotoxicity; electrospray ionization mass spectrometry; glycosides; humans; inhibitory concentration 50; lignans; neoplasm cells; nuclear magnetic resonance spectroscopy; rhizomes; spectral analysis
Abstract:
... Phytochemical investigation of the rhizomes of Smilax trinervula led to isolation and structure elucidation of eight lignan glycosides, including five new lignans, namely, (7S, 8R, 8′R)-4, 4′, 9-trihydroxy-3, 3′, 5, 5′-tetramethoxy-7, 9′-epoxylignan-7′-one 4′-O-β-d-glucopyranoside (1), (7S, 8R, 8′R)-4, 4′, 9-trihydroxy-3, 3′, 5, 5′-tetramethoxy-7, 9′-epoxylignan-7′-one 4-O-β-d- glucopyranoside (2) ...
DOI:
10.1016/j.phytol.2017.03.002

16. Lignans and diterpenes isolated from Tirpitzia ovoidea and their biological activities

Author:
Xue-Yan YANG; Yi-Fan ZHANG; Li-Jia LIU; Yi WANG; Ming-Ying SHANG; Feng XU; Guang-Xue LIU; Shao-Qing CAI
Source:
Chinese journal of natural medicines 2017 v.15 no.12 pp. 938-943
ISSN:
1875-5364
Subject:
Linaceae; Oriental traditional medicine; aerial parts; anti-inflammatory activity; cell lines; cytotoxicity; diterpenoids; ethanol; ethyl acetate; inflammation; inhibitory concentration 50; lignans; macrophages; mice; models; nitric oxide; spectral analysis
Abstract:
... A new lignan, tirpitzin A (17) together with 20 known compounds (1–16, and 18–21) were isolated from the ethyl acetate soluble fraction of ethanol extract of the aerial parts of Tirpitzia ovoidea. The structure of new compound was elucidated by means of spectroscopic analysis. Of the known compounds, 7–21 were isolated from Linaceae family for the first time. The pharmacological activity of the cr ...
DOI:
10.1016/S1875-5364(18)30010-4

17. Lignans from a wild vegetable (Patrinina villosa) able to combat Alzheimer’s disease

Author:
Ming Bai; Guo-Dong Yao; Si-Fan Liu; Di Wang; Qing-Bo Liu; Xiao-Xiao Huang; Shao-Jiang Song
Source:
Journal of functional foods 2017 v.28 pp. 106-113
ISSN:
1756-4646
Subject:
Alzheimer disease; active ingredients; antioxidants; chemical structure; ethanol; functional foods; green leafy vegetables; lignans; molecular models; neuroprotective effect; salads; soups; spectral analysis; tetrahydrofuran; China; Japan; Korean Peninsula; North America
Abstract:
... Patrinina villosa Juss. is a delicious wild vegetable, which is widely distributed in China, Korea, Japan and North America. P. villosa, which smells fresh and is highly nutritious, can be made into a salad, used as greens and as a porridge and soup. Phytochemical investigation of the 70% EtOH extract showed the presence of two dibenzylbutyrolactone lignans (1–2), named Patrinians (A-B), along wit ...
DOI:
10.1016/j.jff.2016.10.024

18. Lignans from the Roots of Taxus wallichiana and Their α-Glucosidase Inhibitory Activities

Author:
Dang Phu H.; Nguyen Hai X.; Nguyen Hanh H. T.; Vo Thai D.; Le Tho H.; Phan Trong H. N.; Nguyen Mai T. T.; Nguyen Nhan T.
Source:
Journal of natural products 2017 v.80 no.6 pp. 1876-1882
ISSN:
1520-6025
Subject:
Taxus wallichiana; alpha-glucosidase; inhibitory concentration 50; lignans; roots; spectral analysis
Abstract:
... From an EtOAc-soluble extract of the roots of Taxus wallichiana, six new (1–6) and 11 known lignans were isolated. The structures of the new compounds were elucidated based on interpretation of spectroscopic data. (+)-7′-epi-Tsugacetal (1) is a rare aryltetralin-type lignan having a cis-orientation of H-7′ and H-8′. Compounds 3–6 were identified as the first naturally occurring tetrahydrofuranoid ...
DOI:
10.1021/acs.jnatprod.7b00171

19. Lignans from the fruits of Schisandra chinensis (Turcz.) Baill inhibit proprotein convertase subtilisin/kexin type 9 expression

Author:
Pisey Pel; Hee-Sung Chae; Piseth Nhoek; Woojin Yeo; Young-Mi Kim; Young-Won Chin
Source:
Phytochemistry 2017 v.136 pp. 119-124
ISSN:
0031-9422
Subject:
Schisandra chinensis; fractionation; fruits; gene expression; inhibitory concentration 50; lignans; low density lipoprotein; messenger RNA; nuclear magnetic resonance spectroscopy; screening; spectral analysis; subtilisin
Abstract:
... Bioactivity-guided fractionation of the fruits of Schisandra chinensis, using the proprotein convertase subtilisin-kexin type 9 (PCSK9) mRNA expression screening assay, led to isolation of two previously unknown lignans, 14-tigloylschinlignan D and rel-(7R, 8R, 7′R, 8′R)-manglisin E, along with 28 known compounds. All structures were established by NMR spectroscopic data as well as CD and MS analy ...
DOI:
10.1016/j.phytochem.2017.01.010

20. Lignans from the root of Wikstroemia indica and their cytotoxic activity against PANC-1 human pancreatic cancer cells

Author:
Hang Chang; Yuwei Wang; Xue Gao; Zehai Song; Suresh Awale; Na Han; Zhihui Liu; Jun Yin
Source:
Fitoterapia 2017 v.121 pp. 31-37
ISSN:
0367-326X
Subject:
Wikstroemia indica; cytotoxicity; humans; lignans; methylene chloride; neoplasm cells; nuclear magnetic resonance spectroscopy; pancreatic neoplasms; roots; spectral analysis
Abstract:
... Six new compounds, wikstronin A (1), wikstronin B (2), wikstresinol (3), acetylwikstresinol (4), bis-5′,5′-(+)-matairesinol (5), bis-5,5′-(+)-matairesinol (6), together with 20 known compounds (7–26) were isolated from the CH2Cl2 extract of roots of Wikstroemia indica. Structures of compounds 1–6 were determined by extensive NMR and CD spectroscopic analysis. In vitro preferential cytotoxicity of ...
DOI:
10.1016/j.fitote.2017.06.012

21. Lignans from the shed trunk barks of the critically endangered plant Abies beshanzuensis and their anti-neuroinflammatory activities

Author:
Chang-Ling Hu; Juan Xiong; Peng Xu; Ke-Jun Cheng; Guo-Xun Yang; Jin-Feng Hu
Source:
Natural product research 2017 v.31 no.12 pp. 1358-1364
ISSN:
1478-6427
Subject:
Abies; inhibitory concentration 50; lignans; mice; nitric oxide; plants (botany); spectral analysis
Abstract:
... During a further and comprehensive phytochemical investigation on the shed trunk barks of the critically endangered plant Abies beshanzuensis , one new (1) and ten known (2 – 11) lignans with diverse structures were isolated. On the basis of spectroscopic methods, the new structure was established to be (7 S ,8 R ,8′ R)-4′-methoxyl- α -conidendrin (1). Among the isolated lignans, (−)-matairesinol ...
DOI:
10.1080/14786419.2016.1247082

22. Lipoxygenase-inhibiting lignans from Clematis mandshurica

Author:
Qiang Fu; Chuang Zhou; Yu Ma; Min Yang; Hai-Mei Yuan; Jiang Chen; Pei-Xi Liu
Source:
Journal of Asian natural products research 2017 v.19 no.9 pp. 884-889
ISSN:
1477-2213
Subject:
linoleate 13S-lipoxygenase; Clematis terniflora var. mandshurica; lignans; hydrolysis; spectral analysis; rhizomes; ethanol; roots
Abstract:
... The EtOH extract of the roots and rhizomes of Clematis mandshurica afforded two new lignans clemomanshurinane C (1) and clemomanshurinane D (2), and three known compounds (3–5). Their structures were elucidated on the basis of spectroscopic means and hydrolysis products. All compounds displayed moderate inhibitory activity against enzyme lipoxygenase. ...
DOI:
10.1080/10286020.2016.1251419

23. Mass spectrometry-based analysis of whole-grain phytochemicals

Author:
Ville Mikael Koistinen; Kati Hanhineva
Source:
Critical reviews in food science and nutrition 2017 v.57 no.8 pp. 1688-1709
ISSN:
1549-7852
Subject:
alkylresorcinols; barley; benzoxazinoids; flavonoids; lignans; liquid chromatography; mass spectrometry; noninfectious diseases; oats; phytosterols; risk; rye; spectral analysis; wheat; whole grain foods
Abstract:
... Whole grains are a rich source of several classes of phytochemicals, such as alkylresorcinols, benzoxazinoids, flavonoids, lignans, and phytosterols. A high intake of whole grains has been linked to a reduced risk of some major noncommunicable diseases, and it has been postulated that a complex mixture of phytochemicals works in synergy to generate beneficial health effects. Mass spectrometry, esp ...
DOI:
10.1080/10408398.2015.1016477

24. Neolignan and megastigmane glucosides from the aerial parts of Isodon japonicus with cell protective effects on BaP-induced cytotoxicity

Author:
Takahiro Matsumoto; Seikou Nakamura; Souichi Nakashima; Tomoe Ohta; Keiko Ogawa; Masashi Fukaya; Junko Tsukioka; Tomohiro Hasei; Tetsushi Watanabe; Hisashi Matsuda
Source:
Phytochemistry 2017 v.137 pp. 101-108
ISSN:
0031-9422
Subject:
aerial parts; chemical structure; cytotoxicity; glucosides; lignans; nuclear magnetic resonance spectroscopy; protective effect; spectral analysis; Japan
Abstract:
... Six neolignan glucosides, named isodonosides I–VI, and a megastigmane glucoside named isodonmegastigmane I, were isolated together with 15 known compounds from the methanolic extract of aerial parts of Isodon japonicus cultivated in Tokushima, Japan. The chemical structures of the compounds were elucidated based on their MS and NMR spectroscopic analysis. The absolute configurations of the neolign ...
DOI:
10.1016/j.phytochem.2017.02.007

25. Neolignan and monoterpene glycoside from the seeds of Pharbitis nil

Author:
Seoung Rak Lee; Eunjung Moon; Ki Hyun Kim
Source:
Phytochemistry letters 2017 v.20 pp. 98-101
ISSN:
1874-3900
Subject:
Ipomoea nil; anti-inflammatory activity; chemical structure; cytotoxicity; ethanol; glycosides; inhibitory concentration 50; lignans; lipopolysaccharides; mice; monoterpenoids; nitric oxide; nuclear magnetic resonance spectroscopy; seeds; spectral analysis
Abstract:
... Phytochemical investigation of an EtOH extract of Pharbitis nil seeds (Convolvulaceae) resulted in the isolation and identification of a new neolignan, 7R,8S-threo-dihydroxydehydrodiconiferyl alcohol (1), and a new monoterpene glycoside, (3Z,7S)-7-hydroxy-3,7-dimethyl-3,8-octadienyl-β-d-glucopyranoside (2), together with a known compound, ethyl α-l-arabinofuranoside (3). The chemical structures of ...
DOI:
10.1016/j.phytol.2017.04.019

26. Neuroprotective Lignans from the Fruits of Schisandra bicolor var. tuberculata

Author:
Liu Ye; Yu Heng-Yi; Wang Yan-Mei; Tian Tian; Wu Wen-Ming; Zhou Ming; Meng Xiang-Gao; Ruan Han-Li
Source:
Journal of natural products 2017 v.80 no.4 pp. 1117-1124
ISSN:
1520-6025
Subject:
Schisandra; X-ray diffraction; chemical structure; fruits; hydrogen peroxide; irradiation; lignans; models; neuroprotective effect; spectral analysis
Abstract:
... Nine new lignans (1–9) and ten known analogues (10–19) were isolated from the fruits of Schisandra bicolor var. tuberculata. The structures of compounds 1–9 were established on the basis of spectroscopic data analysis. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction analysis with Cu Kα irradiation techniques, and the absolute configurations of compounds ...
DOI:
10.1021/acs.jnatprod.7b00035

27. A New Insecticidal Lignan Glucoside from Galium verum

Author:
Jia Chen; Chun-Chao Zhao; Jian-Hua Shao; Ju-Di Fan; Xu-Hua Huang
Source:
Chemistry of natural compounds 2017 v.53 no.4 pp. 626-628
ISSN:
0009-3130
Subject:
Galium verum; Helicoverpa armigera; Scorpiones; chemical structure; glucosides; insecticidal properties; lignans; mortality; poisoning; scorpion venoms; spectral analysis; stomach; toxicity
Abstract:
... A new lignan glucoside, galiveroside A (1), and seven known compounds (2–8), were isolated from Galium verum L. The structure of 1 was elucidated on the basis of extensive spectroscopic analyses. Compound 1, at the concentration of 5 mg/mL, showed insecticide activity to 3 age cotton bollworm with a mortality of 16.3% through stomach poisoning. When combined with a recombinant scorpion toxin rLqh ...
DOI:
10.1007/s10600-017-2075-3

28. A New Lignan Glucoside from Cyclea racemosa

Author:
Jian-Hua Shao; Xue-Wei Zhang; Zi-Ling Dong; Si-Hui Li; Ben-Jie Miao; Ke-Zhi Cheng
Source:
Chemistry of natural compounds 2017 v.53 no.6 pp. 1025-1027
ISSN:
0009-3130
Subject:
Cyclea; chemical structure; glucosides; lignans; spectral analysis
Abstract:
... A new lignan glucoside 1, along with two known lignans (2, 3), was isolated from Cyclea racemosa Oliv. Its structure was elucidated as (+)-7′-methoxylariciresinol 4-O-β-D-glucopyranoside on the basis of extensive spectroscopic analyses. ...
DOI:
10.1007/s10600-017-2193-y

29. New lignan glycosides from the root barks of Litsea glutinosa

Author:
Younan Wu; Yan Jin; Lin Dong; Yiying Li; Caiyun Zhang; Mei Gui; Xiaopo Zhang
Source:
Phytochemistry letters 2017 v.20 pp. 259-262
ISSN:
1874-3900
Subject:
Litsea; anti-inflammatory activity; chemical composition; glycosides; lignans; lipopolysaccharides; macrophages; mice; nitric oxide; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... An investigation on the chemical constituents in the root barks of Litsea glutinosa was performed for the first time. Three new lignan glycosides named Litseasins A–C (1–3), together with a known one (4), were obtained. The structures of the new compounds were established through extensive spectroscopic analyses including HR-ESI–MS, NMR, and circluar dichroism (CD). The new compounds were evaluate ...
DOI:
10.1016/j.phytol.2017.05.005

30. Nine new compounds from the root bark of Lycium chinense and their α-glucosidase inhibitory activity

Author:
Ya-Nan Yang; Ya-Wen An; Zhi-Lai Zhan; Jing Xie; Jian-Shuang Jiang; Zi-Ming Feng; Fei Ye; Pei-Cheng Zhang
Source:
RSC advances 2017 v.7 no.2 pp. 805-812
ISSN:
2046-2069
Subject:
Lycium chinense; acarbose; alpha-glucosidase; bark; cortex; enzyme inhibition; enzyme inhibitors; fruits; glucosides; inhibitory concentration 50; lignans; naphthalene; nuclear magnetic resonance spectroscopy; sesquiterpenoids; shrubs; spectral analysis
Abstract:
... Lycium chinense Mill. is a deciduous shrub in the Solanaceae family that is known for its fruits (Lycii fructus) and root bark (Lycii cortex). In our ongoing search for α-glucosidase inhibitors from the root bark of L. chinense, lyciumflavane A, one new flavane with an unusual benzofuran unit, one new amide possessing a naphthalene skeleton, one new sesquiterpene, three new lignan glucosides, and ...
DOI:
10.1039/c6ra24751b

31. One new lignan derivative from the Combretum alfredii Hance

Author:
Meng Bai; Li-Jun Wu; Yue Cai; Shou-Yuan Wu; Xiao-Ping Song; Guang-Ying Chen; Cai-Juan Zheng; Chang-Ri Han
Source:
Natural product research 2017 v.31 no.9 pp. 1022-1027
ISSN:
1478-6427
Subject:
Combretum; antibacterial properties; bacteria; branches; ethanol; leaves; lignans; spectral analysis; China
Abstract:
... One new lignan derivative 2,3-dimethyl-4-(4-methoxyphenyl)-6,7-dihydroxynaphthalene (1), together with five known compounds (2 – 6), were isolated from ethanol extract of the branches and leaves of Combretum alfredii Hance collected in Hainan Province, China. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compounds 1 , 2 , 5 and 6 were isolated from ...
DOI:
10.1080/14786419.2016.1266348

32. Phenolics and neolignans isolated from the fruits of Juglans mandshurica Maxim. and their effects on lipolysis in adipocytes

Author:
SeonJu Park; Nanyoung Kim; Guijae Yoo; Sang-Nam Kim; Hyun-Jung Kwon; Kiwon Jung; Dong-Chan Oh; Yun-Hee Lee; Seung Hyun Kim
Source:
Phytochemistry 2017 v.137 pp. 87-93
ISSN:
0031-9422
Subject:
Juglans mandshurica; adipocytes; fibroblasts; fruits; lignans; lipolysis; mice; nuclear magnetic resonance spectroscopy; skin diseases; spectral analysis; traditional medicine; China; Korean Peninsula
Abstract:
... Juglans mandshurica Maxim. (Juglandaceae) is a traditional folk medicine used for treatment of dermatosis and to relieve aches in Korea and China. In this study, eight compounds, along with six known compounds, were isolated from the fruit of J. mandshurica. Among the six known compounds, the absolute configuration of two compounds were determined. The structures of compounds were determined on th ...
DOI:
10.1016/j.phytochem.2017.01.019

33. Phytochemical study of Joannesia princeps Vell. (Euphorbiaceae) leaves

Author:
César Muñoz Camero; Abeer Temraz; Alessandra Braca; Marinella De Leo
Source:
Biochemical systematics and ecology 2017 v.70 pp. 69-72
ISSN:
0305-1978
Subject:
Euphorbiaceae; chemotaxonomy; flavonoids; glycosylation; leaves; lignans; metabolites; methanol; monoterpenoids; spectral analysis
Abstract:
... A phytochemical study of chloroform-methanol and methanol extracts of Joannesia princeps Vell. Leaves led to the isolation of twenty eight compounds, including two α-ionones (2, 5), three glycosylated monoterpenes (1, 3, 4), eight phenolic compounds (6, 8, 9, 12, 14, 17, 18, 24), two gallotannins (10, 11), twelve flavonoids (7, 15, 16, 19, 20–23, 25–28), and one lignan (13). The structural charact ...
DOI:
10.1016/j.bse.2016.10.023

34. Prenylated phenylpropanoids with unprecedented skeletons from Illicium burmanicum

Author:
Xinhui Tian; Xin Guo; Zhiguo Zhuo; Rentao Zeng; Xin Fang; Xike Xu; Huiliang Li; Yunheng Shen; Weidong Zhang
Source:
RSC advances 2017 v.7 no.18 pp. 10849-10854
ISSN:
2046-2069
Subject:
Illicium; branches; chemical constituents of plants; circular dichroism spectroscopy; cytotoxicity; inhibitory concentration 50; leaves; lignans; nuclear magnetic resonance spectroscopy; phenylpropanoids; spectral analysis
Abstract:
... A phytochemical investigation on the branches and leaves of Illicium burmanicum led to the isolation of two unique allo-thujane-phenylpropane and lavandulane-phenylpropane hetero-adducts (1 and 2), two new prenylated phenylpropanoids (3 and 4), and one new neolignan (5). Their structures were established by comprehensive NMR and CD spectroscopic analysis. Burmaniols A (1) and B (2) showed apprecia ...
DOI:
10.1039/c7ra01143a

35. Seven new lignan glycosides from the branches of Alangium kurzii Craib var. laxifolium

Author:
Jie Ren; Yang-guo Xie; Ying-ying Huang; Sheng-lan Zhu; Shi-kai Yan; Hui-zi Jin; Wei-dong Zhang
Source:
Fitoterapia 2017 pp. -
ISSN:
0367-326X
Subject:
Aeromonas hydrophila; Alangium; Enterococcus faecalis; Escherichia coli; Klebsiella pneumoniae; Pseudomonas aeruginosa; Salmonella Gallinarum; Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus agalactiae; Streptococcus suis; Vibrio parahaemolyticus; X-radiation; antibacterial properties; branches; circular dichroism spectroscopy; glycosides; lignans; medicinal plants; minimum inhibitory concentration; spectral analysis
Abstract:
... Seven new lignan glycosides (1–3, 8–10, and 14) and 17 known compounds were isolated from the branches of Alangium kurzii Craib var. laxifolium. Their structures were established by spectroscopic analysis and circular dichroism (CD) and X-ray analysis. The isolated compounds were evaluated for their antibacterial activities against Staphylococcus aureus CI1011, Streptococcus suis CI1608, Salmonell ...
DOI:
10.1016/j.fitote.2017.07.009

36. Specialized metabolites from the aerial parts of Centaurea polyclada DC.

Author:
Serdar Demir; Canan Karaalp; Erdal Bedir
Source:
Phytochemistry 2017 v.143 pp. 12-18
ISSN:
0031-9422
Subject:
Centaurea; aerial parts; chemical degradation; flavonoids; flora; glucosides; lignans; mass spectrometry; metabolites; nuclear magnetic resonance spectroscopy; sesquiterpenoid lactones; spectral analysis; Turkey (country)
Abstract:
... The genus Centaurea L. (Asteraceae) is represented by 200 taxa in the flora of Turkey and several Centaurea species are used as herbal remedies against different conditions. Previous phytochemical investigations on this genus generally revealed the isolation of sesquiterpene lactones and flavonoid derivatives. In our continuous search on Centaurea genus, a phytochemical study was performed on Cent ...
DOI:
10.1016/j.phytochem.2017.07.002

37. Two new lignan-iridoid glucoside diesters from the leaves of Vaccinium bracteatum and their relative and absolute configuration determination by DFT NMR and TDDFT-ECD calculation

Author:
Yong-Mei Ren; Chang-Qiang Ke; Attila Mándi; Tibor Kurtán; Chunping Tang; Sheng Yao; Yang Ye
Source:
Tetrahedron 2017 pp. -
ISSN:
0040-4020
Subject:
Vaccinium bracteatum; biochemical pathways; chemical reactions; chemical structure; circular dichroism spectroscopy; glucosides; iridoids; leaves; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Two new lignan-iridoid glucoside diesters (2 and 3), together with their putative biosynthetic precursor 10-O-trans-caffeoyl-6α-hydroxyl-dihydromonotropein (1), were characterized from the leaves of Vaccinium bracteatum. Their planar structures and relative configuration were elucidated by spectroscopic measurements and DFT C NMR calculations, and their absolute configurations were determined by t ...
DOI:
10.1016/j.tet.2017.04.040

38. Two new lignans from Saururus chinensis

Author:
Cuibai Li; Ningxin Li; Jiarui Yue; Qishi Song; Qingfei Fan
Source:
Natural product research 2017 v.31 no.14 pp. 1598-1603
ISSN:
1478-6427
Subject:
Saururus chinensis; antineoplastic activity; cytotoxicity; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Two new lignans, (Z)-14-bis(3′,4′-dimethoxyphenyl)-2,3-dimethylbut-2-ene-1,4-dione (1), threo -2-methyl-3-oxo-1-(3′,4′,5′-trimethoxyphenyl)butyl-3″,4″-dimethoxybenzoate (2), together with 15 known derivatives (3 – 17) were isolated from Saururus chinensis . Their structures were determined on the basis of spectral data, including 1D and 2D NMR experiments and HREIMS spectra. The antitumour activit ...
DOI:
10.1080/14786419.2017.1286483

39. A new lignan and a new terpenoid from Achillea millefolium L

Author:
Jing Liu; Dan Wang; Li He; Qi Mao; Xiaofang Hu
Source:
Phytochemistry letters 2017 v.22 pp. 247-250
ISSN:
1874-3900
Subject:
Achillea millefolium; lignans; luteolin; methanol; nuclear magnetic resonance spectroscopy; spectral analysis; terpenoids
Abstract:
... A phytochemical investigation from methanol extract of Achillea millefolium, (Asteraceae) resulted in the isolation of one new lignan, (+)-lyoniresinol 4-O-α-l −arabinofuranoside (1) and one new terpenoid, achiterpenoside A (2), together with four other known compounds, named as Achillinin A (3), (+)-lyoniresinol (4), luteolin (5), camazulene (6). The structures of 1 and 2 were elucidated based on ...
DOI:
10.1016/j.phytol.2017.10.009

40. The structure proposed for apteniol D is different from that of the compound obtained by total synthesis

Author:
Toshiro Noshita; Kohei Matsumoto; Hikaru Nishikawa; Hidekazu Ouchi; Yoshitomo Hamada; Akiko Saito; Teiko Yamada
Source:
Natural product research 2017 v.31 no.2 pp. 163-168
ISSN:
1478-6427
Subject:
chemical reactions; chemical structure; copper; diphenyl ethers; lignans; spectral analysis
Abstract:
... We describe the synthesis of 4,4′-oxyneolignan, the proposed structure for naturally occurring apteniol D. The diphenyl ether moiety in 4,4′-oxyneolignan was formed via classical Ullmann ether synthesis using excess copper powder in N,N -dimethylacetamide. The spectral data of synthesised apteniol D show differences compared to those of naturally occurring apteniol D. ...
DOI:
10.1080/14786419.2016.1224867

41. α-Glucosidase inhibitors from the stem of Mangifera reba

Author:
Truc T.T. Duong; Truong N.V. Do; Hai X. Nguyen; Tho H. Le; Phu H. Dang; Nhan T. Nguyen; Tuyen N.T. Nguyen; Thao D. Nguyen; Mai T.T. Nguyen
Source:
Tetrahedron letters 2017 pp. -
ISSN:
0040-4039
Subject:
Mangifera; acarbose; alpha-glucosidase; biochemical pathways; chemical reactions; chemical structure; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Two new neolignans, named rebaneolignan A (1) and B (2), were isolated from the stem of Mangifera reba (Anacardiaceae), together with six known compounds (3–8). Their structures were elucidated on the basis of NMR spectroscopic analysis and the absolute configurations of 1 and 2 were determined by NOESY and CD data. All isolated compounds were found to possess more potent inhibitory activity, with ...
DOI:
10.1016/j.tetlet.2017.04.092