Publication year rev: 7983-2017 / Subject term: adaptive immunity

1. Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14 Attenuate Gardnerella vaginalis-Infected Bacterial Vaginosis in Mice

Author:: Se-Eun Jang; Jin-Ju Jeong; Su-Young Choi; Hyunji Kim; Myung Joo Han; Dong-Hyun Kim
Source:: Nutrients 2017 v.9 no.6 pp. -
ISSN:: 2072-6643
Subject:: Gardnerella vaginalis; Lactobacillus acidophilus; Lactobacillus rhamnosus; adaptive immunity; enzyme activity; enzyme-linked immunosorbent assay; epithelial cells; flow cytometry; human cell lines; humans; immunoblotting; immunosuppression; ingredients; interleukin-10; interleukin-17; interleukin-1beta; intravaginal devices; lactoferrin; macrophages; mice; myeloperoxidase; neoplasm cells; oral administration; probiotics; quantitative polymerase chain reaction; splenocytes; transcription factor NF-kappa B; tumor necrosis factor-alpha; uterine cervical neoplasms; vagina; women
Abstract:: ... Oral administration of a probiotic mixture (PM; Respecta®) consisting of Lactobacillus rhamnosus HN001 (L1), Lactobacillus acidophilus La-14 (L2), and lactoferrin RCXTM results in colonization of these probiotics in the vagina of healthy women. Therefore, we examined whether vaginal colonization of the PM ingredients L1 and L2 could attenuate bacterial vaginosis (BV). BV was induced in mice via β- ...
DOI:: 10.3390/nu9060531
PubMed:: 28545241
PubMed Central:: PMC5490510
: https://doi.org/10.3390/nu9060531

2. Administration of a polyphenol-enriched feed to farmed sea bass (Dicentrarchus labrax L.): Kidney melanomacrophages response

Author:: Marcella Arciuli; Daniela Fiocco; Sergio Fontana; Mattia Pia Arena; Maria Antonia Frassanito; Anna Gallone
Source:: Fish & shellfish immunology 2017 v.68 pp. 404-410
ISSN:: 1050-4648
Subject:: Dicentrarchus labrax; Vitis vinifera; adaptive immunity; bass; biosynthesis; diet; enzyme activity; essential oils; flavanols; gene expression; health status; immune response; immunostimulants; innate immunity; juveniles; kidneys; melanin; pathogens; polyphenols; seeds; spleen; vaccines
Abstract:: ... The reinforcement of the defense mechanism of fish, through the administration of immunostimulants, is considered as a promising alternative to vaccines. Natural immunostimulants such as polyphenols, flavanoids, pigments and essential oils can modulate the innate immune response. In lower vertebrates, melano-macrophage centres, i.e. clusters of pigment-containing cells forming the extracutaneous p ...
DOI:: 10.1016/j.fsi.2017.07.043
: https://doi.org/10.1016/j.fsi.2017.07.043

3. Alteration of the number and percentage of innate immune cells in preschool children from an e-waste recycling area

Author:: Yu Zhang; Xijin Xu; Di Sun; Junjun Cao; Yuling Zhang; Xia Huo
Source:: Ecotoxicology and environmental safety 2017 v.145 pp. 615-622
ISSN:: 0147-6513
Subject:: adaptive immunity; atomic absorption spectrometry; basophils; cadmium; electronic wastes; eosinophils; flow cytometry; heavy metals; hematology; lead; monocytes; neutrophils; pollution; preschool children; recycling
Abstract:: ... Heavy metal lead (Pb) and cadmium (Cd) are widespread environmental contaminants and exert detrimental effects on the immune system. We evaluated the association between Pb/Cd exposures and innate immune cells in children from an electronic waste (e-waste) recycling area. A total number of 294 preschool children were recruited, including 153 children from Guiyu (e-waste exposed group), and 141 fro ...
DOI:: 10.1016/j.ecoenv.2017.07.059
: https://doi.org/10.1016/j.ecoenv.2017.07.059

4. Altered distribution of peripheral blood dendritic cell subsets in patients with pulmonary paracoccidioidomycosis

Author:: James Venturini; Ricardo Souza Cavalcante; Daniela Vanessa Moris; Márjorie de Assis Golim; Adriele Dandara Levorato; Karoline Hagatha dos Reis; Maria Sueli Parreira de Arruda; Rinaldo Poncio Mendes
Source:: Acta tropica 2017 pp. -
ISSN:: 0001-706X
Subject:: Paracoccidioides; adaptive immunity; adults; blood serum; chemokine CCL3; complications (disease); dendritic cells; enzyme-linked immunosorbent assay; fibroblast growth factor 2; fibrosis; flow cytometry; fungi; hypoxia; immune response; interleukin-10; interleukin-18; interleukin-1beta; lungs; models; mucosa; mycoses; patients; pulmonary emphysema; tumor necrosis factor-alpha; Latin America
Abstract:: ... Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi from the genus Paracoccidioides in Latin America. PCM-patients (PCM-p) are classified as having acute/subacute or chronic (CF) clinical forms. CF is responsible for 75% − 90% of all cases, affects mainly adults over 30 years old and the clinical manifestation are associated mainly with lungs and mucosa of upper airdigestive tract. ...
DOI:: 10.1016/j.actatropica.2017.06.007
: https://doi.org/10.1016/j.actatropica.2017.06.007

5. Antibodies: From novel repertoires to defining and refining the structure of biologically important targets

Author:: Paul J. Conroy; Ruby H.P. Law; Tom T. Caradoc-Davies; James C. Whisstock
Source:: Methods 2017 v.116 pp. 12-22
ISSN:: 1046-2023
Subject:: adaptive immunity; antibodies; antigens; crystallography; high-throughput nucleotide sequencing; human health; humans; rodents; screening
Abstract:: ... Antibodies represent a highly successful class of molecules that bind a wide-range of targets in therapeutic-, diagnostic- and research-based applications. The antibody repertoire is composed of the building blocks required to develop an effective adaptive immune response against foreign insults. A number of species have developed novel genetic and structural mechanisms from which they derive thes ...
DOI:: 10.1016/j.ymeth.2017.01.003
: https://doi.org/10.1016/j.ymeth.2017.01.003

6. Antigenic GM3 Lactone Mimetic Molecule Integrated Mannosylated Glycopeptide Nanofibers for the Activation and Maturation of Dendritic Cells

Author:: Gunay Gokhan; Sardan Ekiz Melis; Ferhati Xhenti; Richichi Barbara; Nativi Cristina; Tekinay Ayse B.; Guler Mustafa O.
Source:: ACS Applied Materials & Interfaces 2017 v.9 no.19 pp. 16035-16042
ISSN:: 1944-8252
Subject:: adaptive immunity; antigens; dendritic cells; glycopeptides; nanofibers; neoplasms; pathogens; vaccination
Abstract:: ... The ability of dendritic cells to coordinate innate and adaptive immune responses makes them essential targets for vaccination strategies. Presentation of specific antigens by dendritic cells is required for the activation of the immune system against many pathogens and tumors, and nanoscale materials can be functionalized for active targeting of dendritic cells. In this work, we integrated an imm ...
DOI:: 10.1021/acsami.7b04094
: https://doi.org/10.1021/acsami.7b04094

7. Application of the CRISPR gene‐editing technique in insect functional genome studies – a review

Author:: Yubao Cui; Jin‐Lu Sun; LiLi Yu
Source:: Entomologia experimentalis et applicata 2017 v.162 no.2 pp. 124-132
ISSN:: 0013-8703
Subject:: CRISPR sequences; DNA; Danio rerio; Diptera; Nematoda; adaptive immunity; bacteria; bacteriophages; gene editing; genome; humans; insects; mice; rats; ribonucleases; yeasts
Abstract:: ... The clustered regularly interspaced short palindromic repeats (CRISPR) structural family form an acquired immune system in bacteria that is able to degrade invading virus or phage DNA. The CRISPR/Cas system has been co‐opted as an RNA‐mediated nuclease for use in targeted genome engineering. The CRISPR/Cas system provides a novel tool for manipulating genomic DNA using an approach that is simple, ...
DOI:: 10.1111/eea.12530
: https://doi.org/10.1111/eea.12530

8. The Arp2/3 complex binding protein HS1 is required for efficient dendritic cell random migration and force generation

Author:: Amy C. Bendell; Edward K. Williamson; Christopher S. Chen; Janis K. Burkhardt; Daniel A. Hammer
Source:: Integrative biology 2017 v.9 no.8 pp. 695-708
ISSN:: 1757-9708
Subject:: actin; adaptive immunity; binding proteins; cell movement; dendritic cells; detectors; lymph nodes; microfilaments; polymerization; wasps
Abstract:: ... Dendritic cell migration to the T-cell-rich areas of the lymph node is essential for their ability to initiate the adaptive immune response. While it has been shown that the actin cytoskeleton is required for normal DC migration, the role of many of the individual cytoskeletal molecules is poorly understood. In this study, we investigated the contribution of the Arp2/3 complex binding protein, hae ...
DOI:: 10.1039/c7ib00070g
PubMed:: 28678266
PubMed Central:: PMC5830129
: https://doi.org/10.1039/c7ib00070g

9. Assessing in vivo digestibility and effects on immune system of sheep fed alfalfa hay supplemented with a fixed amount of Ulva rigida and Gracilaria vermiculophylla

Author:: Ana R. J. Cabrita; Alexandra Correia; Ana R. Rodrigues; Paulo P. Cortez; Manuel Vilanova; António J.M. Fonseca
Source:: Journal of applied phycology 2017 v.29 no.2 pp. 1057-1067
ISSN:: 0921-8971
Subject:: B-lymphocytes; Gracilaria; Ulva rigida; adaptive immunity; alfalfa hay; diet; digestibility; digestible energy; ecosystems; hematologic tests; immune response; in vivo studies; macroalgae; neutrophils; organic matter; polysaccharides; reactive oxygen species; rumen; sheep
Abstract:: ... Ruminants could be the most suitable domestic animals to be supplemented with seaweeds as the rumen ecosystem might provide the animal the ability to use these feed resources by breaking down the complex polysaccharides. The objective of the present in vivo study was to determine the digestibility and the effects on the immune system of one green (Ulva rigida) and one red (Gracilaria vermiculophyl ...
DOI:: 10.1007/s10811-016-0999-9
: https://doi.org/10.1007/s10811-016-0999-9

10. Autophagy induced by infectious hematopoietic necrosis virus inhibits intracellular viral replication and extracellular viral yields in epithelioma papulosum cyprini cell line

Author:: Jing-Zhuang Zhao; Li-Ming Xu; Miao Liu; Zhen-yu Zhang; Jia-Sheng Yin; Hong-Bai Liu; Tong-Yan Lu
Source:: Developmental and comparative immunology 2017 v.77 pp. 88-94
ISSN:: 0145-305X
Subject:: Infectious hematopoietic necrosis virus; Salmonidae; Western blotting; adaptive immunity; aquaculture industry; autophagy; cell lines; disease severity; electron microscopy; fluorescence microscopy; pathogens; rapamycin; virus replication
Abstract:: ... Infectious hematopoietic necrosis virus (IHNV) is a common pathogen that causes severe disease in the salmonid aquaculture industry. Recent work demonstrated that autophagy plays an important role in pathogen invasion by activating innate and adaptive immunity. This study investigated the relationship between IHNV and autophagy in epithelioma papulosum cyprini cells. The electron microscopy result ...
DOI:: 10.1016/j.dci.2017.07.025
: https://doi.org/10.1016/j.dci.2017.07.025

11. Axl signaling induces development of natural killer cells in vitro and in vivo

Author:: Eun-Mi Kim; Eun-Hee Lee; Hwa-Yeon Lee; Ha-Rim Choi; Kon-Young Ji; Su-Man Kim; Kwang Dong Kim; Hyung-Sik Kang
Source:: Protoplasma 2017 v.254 no.2 pp. 1091-1101
ISSN:: 0033-183X
Subject:: adaptive immunity; antibodies; antigen-presenting cells; autoimmunity; bone marrow; cell viability; chemical elements; gene expression regulation; genes; hematopoietic stem cells; innate immunity; interferon-gamma; ligands; metastasis; mice; natural killer cells; neoplasm cells; receptor protein-tyrosine kinase; receptors
Abstract:: ... Natural killer (NK) cells have been well known to play a critical role in innate immunity, but they are also capable of regulating adaptive immunity through the induction of T cell-mediated memory response and B cell-mediated autoimmune response. NK cells are differentiated from hematopoietic stem cells (HSCs) in the bone marrow (BM), and a series of surface molecules are expressed on NK cells in ...
DOI:: 10.1007/s00709-016-1016-5
: https://doi.org/10.1007/s00709-016-1016-5

12. BCG immune activation reduces growth and angiogenesis in an in vitro model of head and neck squamous cell carcinoma

Author:: Carolina Sánchez-Rodríguez; Keyliz Peraza Cruces; Juan Riestra Ayora; Eduardo Martín-Sanz; Ricardo Sanz-Fernández
Source:: Vaccine 2017 v.35 no.47 pp. 6395-6403
ISSN:: 0264-410X
Subject:: BCG vaccine; CD8-positive T-lymphocytes; adaptive immunity; angiogenesis; angiopoietin-2; antigens; antineoplastic activity; apoptosis; caspase-3; coculture; cytotoxicity; endothelial cells; head; humans; immunosuppression; interferon-gamma; interleukin-6; models; morbidity; neck; patients; squamous cell carcinoma; tumor necrosis factor-alpha; vaccination; vascular endothelial growth factors
Abstract:: ... Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers worldwide and is associated with poor survival and significant treatment morbidity. The immune profile in patients with HNSCC is immunosuppressive and presents cytokine-mediated adaptive immune responses, triggered apoptosis of T cells, and alterations in antigen processing machinery. Bacille Calmette-Guerin (BCG) im ...
DOI:: 10.1016/j.vaccine.2017.10.008
: https://doi.org/10.1016/j.vaccine.2017.10.008

13. Bacterial Virulence Factors: Secreted for Survival

Author:: Aditya Kumar Sharma; Neha Dhasmana; Neha Dubey; Nishant Kumar; Aakriti Gangwal; Meetu Gupta; Yogendra Singh
Source:: Indian journal of microbiology 2017 v.57 no.1 pp. 1-10
ISSN:: 0046-8991
Subject:: Mycobacterium; adaptive immunity; adhesion; animal pathogens; bacteria; chemical elements; virulence
Abstract:: ... Virulence is described as an ability of an organism to infect the host and cause a disease. Virulence factors are the molecules that assist the bacterium colonize the host at the cellular level. These factors are either secretory, membrane associated or cytosolic in nature. The cytosolic factors facilitate the bacterium to undergo quick adaptive—metabolic, physiological and morphological shifts. T ...
DOI:: 10.1007/s12088-016-0625-1
PubMed:: 28148975
PubMed Central:: PMC5243249
: https://doi.org/10.1007/s12088-016-0625-1

14. Bacterial ghosts as adjuvants: mechanisms and potential

Author:: Irshad A. Hajam; Pervaiz A. Dar; Gayeon Won; John Hwa Lee
Source:: Veterinary research 2017 v.48 no.1 pp. 37
ISSN:: 1297-9716
Subject:: B-lymphocytes; Gram-negative bacteria; adaptive immunity; adjuvants; agonists; animal models; antigens; cytokines; dendritic cells; immune response; immunostimulants; lymph nodes; transfection; vaccines
Abstract:: ... Bacterial ghosts (BG) are empty cell envelopes derived from Gram-negative bacteria. They contain many innate immunostimulatory agonists, and are potent activators of a broad range of cell types involved in innate and adaptive immunity. Several considerable studies have demonstrated the effectiveness of BG as adjuvants as well as their ability to induce proinflammatory cytokine production by a rang ...
DOI:: 10.1186/s13567-017-0442-5
PubMed:: 28645300
PubMed Central:: PMC5482964
: https://doi.org/10.1186/s13567-017-0442-5

15. Bead-based flow-cytometry for semi-quantitative analysis of complex membrane vesicle populations released by bacteria and host cells

Author:: Charlotte Volgers; Birke J. Benedikter; Gert E. Grauls; Paul H.M. Savelkoul; Frank R.M. Stassen
Source:: Microbiological research 2017 v.200 pp. 25-32
ISSN:: 0944-5013
Subject:: adaptive immunity; bacteria; environmental factors; flow cytometry; pathogenicity; screening
Abstract:: ... During infection, the release of nano-sized membrane vesicle is a process which is common both for bacteria and host cells. Host cell-derived membrane vesicles can be involved in innate and adaptive immunity whereas bacterial membrane vesicles can contribute to bacterial pathogenicity. To study the contribution of both membrane vesicle populations during infection is highly complicated as most ves ...
DOI:: 10.1016/j.micres.2017.04.003
: https://doi.org/10.1016/j.micres.2017.04.003

16. Bioengineering towards self-assembly of particulate vaccines

Author:: Bernd H.A. Rehm
Source:: Current opinion in biotechnology 2017 v.48 pp. 42-53
ISSN:: 0958-1669
Subject:: adaptive immunity; antigen-presenting cells; antigens; bioengineering; immune response; infectious diseases; pathogens; polyesters; proteins; subunit vaccines
Abstract:: ... There is an unmet demand for safe and efficient vaccines for prevention of various infectious diseases. Subunit vaccines comprise selected pathogen specific antigens are a safe alternative to whole organism vaccines. However they often lack immunogenicity. Natural and synthetic self-assembling polymers and proteins will be reviewed in view their use to encapsulate and/or display antigens to serve ...
DOI:: 10.1016/j.copbio.2017.03.018
: https://doi.org/10.1016/j.copbio.2017.03.018

17. Biomaterials innovation for next generation ex vivo immune tissue engineering

Author:: Ankur Singh
Source:: Biomaterials 2017 pp. -
ISSN:: 0142-9612
Subject:: T-lymphocytes; adaptive immunity; animal models; biocompatible materials; immunomodulation; immunotherapy; lymphatic system; medicine; mice; natural selection; researchers; tissue culture; tissue engineering; tissues
Abstract:: ... Primary and secondary lymphoid organs are tissues that facilitate differentiation of B and T cells, leading to the induction of adaptive immune responses. These organs are present in the body from birth and are also recognized as locations where self-reactive B and T cells can be eliminated during the natural selection process. Many insights into the mechanisms that control the process of immune c ...
DOI:: 10.1016/j.biomaterials.2017.03.015
: https://doi.org/10.1016/j.biomaterials.2017.03.015

18. Bovine single chain Fv antibody inhibits bovine herpesvirus-1 infectivity by targeting viral glycoprotein D

Author:: Jian Xu; Jing Wu; Bo Jiang; Houjun He; Xixi Zhang; Xiaoyang Li; Dawei Yang; Xiufen Huang; Joshua E. Sealy; Munir Iqbal; Yongqing Li
Source:: Applied microbiology and biotechnology 2017 v.101 no.23-24 pp. 8331-8344
ISSN:: 0175-7598
Subject:: epitopes; hybridomas; Bovine alphaherpesvirus 1; molecular models; glycoproteins; adaptive immunity; cattle; Western blotting; enzyme-linked immunosorbent assay; monoclonal antibodies; pathogenicity; genes; neutralizing antibodies; viruses; kidneys; recombinant antibodies; fluorescent antibody technique; Escherichia coli
Abstract:: ... Glycoprotein D (gD) of bovine herpesvirus-1 (BoHV-1) is essential for attachment and penetration of cells during infection and is a major target for neutralizing antibodies during an adaptive immune response. Currently there are no recombinant antibodies capable of binding gD epitopes for use in treating BoHV-1 infection. In this study, a bovine scFv gene derived from a hybridoma secreting monoclo ...
DOI:: 10.1007/s00253-017-8566-0
: https://doi.org/10.1007/s00253-017-8566-0

19. CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis

Author:: Raquel Ferraz; Clarissa F. Cunha; Maria Inês F. Pimentel; Marcelo R. Lyra; Tatiana Pereira-Da-Silva; Armando O. Schubach; Alda Maria Da-Cruz; Alvaro Luiz Bertho
Source:: Parasites & vectors 2017 v.10 no.1 pp. 219
ISSN:: 1756-3305
Subject:: CD8-positive T-lymphocytes; Leishmania braziliensis; adaptive immunity; cutaneous leishmaniasis; cytokines; cytotoxicity; dendritic cells; flow cytometry; immune response; inflammation; macrophages; natural killer cells; pathogenesis; patients; therapeutics
Abstract:: ... BACKGROUND: Cutaneous leishmaniasis (CL) is caused by Leishmania (Viannia) braziliensis, which infects dermal macrophages and dendritic cells, causing an intense immune-mediated-tissue inflammation and a skin ulcer with elevated borders that can heal spontaneously or after antimonial therapy. The resolution of lesions depends on an adaptive immune response, and cytotoxic cells seem to have a funda ...
DOI:: 10.1186/s13071-017-2152-2
PubMed:: 28468680
PubMed Central:: PMC5415843
: https://doi.org/10.1186/s13071-017-2152-2

20. CD44 enhances macrophage phagocytosis and plays a protective role in Streptococcus equi subsp. zooepidemicus infection

Author:: Qiang Fu; Zigong Wei; Pingping Xiao; Yaosheng Chen; Xiaohong Liu
Source:: Veterinary microbiology 2017 v.198 pp. 121-126
ISSN:: 0378-1135
Subject:: Streptococcus equi subsp. zooepidemicus; adaptive immunity; death; macrophages; mice; pathogens; phagocytosis; protective effect
Abstract:: ... Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is an important pathogen associated with a wide range of diseases in many mammalian species. CD44 is a transmembrane adhesion molecule involved in innate and adaptive immune responses. The aim of this study was to determine the protective role of CD44 during S. zooepidemicus infection. CD44-deficient mice exhibited reduced macrophage accum ...
DOI:: 10.1016/j.vetmic.2016.12.030
: https://doi.org/10.1016/j.vetmic.2016.12.030

21. CRISPR/Cas9 in insects: Applications, best practices and biosafety concerns

Author:: Clauvis Nji Tizi Taning; Benigna Van Eynde; Na Yu; Sanyuan Ma; Guy Smagghe
Source:: Journal of insect physiology 2017 v.98 pp. 245-257
ISSN:: 0022-1910
Subject:: applied research; adaptive immunity; gene editing; biosafety; genes; insect physiology; RNA; insects
Abstract:: ... Discovered as a bacterial adaptive immune system, CRISPR/Cas9 (clustered, regularly interspaced, short palindromic repeat/CRISPR associated) is being developed as an attractive tool in genome editing. Due to its high specificity and applicability, CRISPR/Cas9-mediated gene editing has been employed in a multitude of organisms and cells, including insects, for not only fundamental research such as ...
DOI:: 10.1016/j.jinsphys.2017.01.007
: https://doi.org/10.1016/j.jinsphys.2017.01.007

22. Characteristics of NK cells from leukemic microenvironment in MLL-AF9 induced acute myeloid leukemia

Author:: Feifei Yang; Rong Wang; Wenli Feng; Chong Chen; Xiao Yang; Lina Wang; Yuting Hu; Qian Ren; Guoguang Zheng
Source:: Molecular Immunology 2017 pp. -
ISSN:: 0161-5890
Subject:: CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; adaptive immunity; cytokines; cytotoxicity; mice; models; myeloid leukemia; natural killer cells; phenotype; spleen
Abstract:: ... NK cells are indispensable components of tissue microenvironment and play vital in both innate and adaptive immunity. The activation and function of NK cells are affected by tumor microenvironments. NK cells are also important players in leukemic microenvironment. However, their characteristics in leukemic microenvironment, including maturation status, phenotype, subpopulations and functional role ...
DOI:: 10.1016/j.molimm.2017.11.003
: https://doi.org/10.1016/j.molimm.2017.11.003

23. Characterization and complete genome sequences of L. rhamnosus DSM 14870 and L. gasseri DSM 14869 contained in the EcoVag® probiotic vaginal capsules

Author:: Harold Marcotte; Kasper Krogh Andersen; Yin Lin; Fanglei Zuo; Zhu Zeng; Per Göran Larsson; Erik Brandsborg; Gunnar Brønstad; Lennart Hammarström
Source:: Microbiological research 2017 v.205 pp. 88-98
ISSN:: 0944-5013
Subject:: Gardnerella vaginalis; Lactobacillus gasseri; Lactobacillus rhamnosus; acidification; adaptive immunity; adhesins; adhesion; amino acids; antibiotic resistance; antibiotics; antimicrobial properties; bacteria; biosynthesis; culture media; epithelial cells; exopolysaccharides; fimbriae; genetic resistance; human cell lines; hydrogen peroxide; multigene family; nucleotide sequences; pH; probiotics; relapse; sequence analysis; therapeutics; women
Abstract:: ... Lactobacillus rhamnosus DSM 14870 and Lactobacillus gasseri DSM 14869 were previously isolated from the vaginal epithelial cells (VEC) of healthy women and selected for the development of the vaginal EcoVag® probiotic capsules. EcoVag® was subsequently shown to provide long-term cure and reduce relapse of bacterial vaginosis (BV) as an adjunct to antibiotic therapy. To identify genes potentially i ...
DOI:: 10.1016/j.micres.2017.08.003
: https://doi.org/10.1016/j.micres.2017.08.003

24. Characterization of a specific monoclonal antibody against immunoglobulin light kappa/L1 chain in olive flounder (Paralichthys olivaceus)

Author:: Young Kyu Kim; Jung Seok Lee; Jae Wook Jung; Jun-ichi Hikima; Maki Ohtani; Ho Bin Jang; Seong Won Nho; In Seok Cha; Seong Bin Park; Jeong Ho Lee; Takashi Aoki; Tae Sung Jung
Source:: Fish & shellfish immunology 2017 v.60 pp. 88-96
ISSN:: 1050-4648
Subject:: Paralichthys olivaceus; adaptive immunity; flounder; immune response; immunoglobulins; lymphocytes; mammals; monoclonal antibodies; spleen
Abstract:: ... Immunoglobulins (Ig) are heterodimeric proteins that play critical roles in the adaptive immune system of vertebrates. Because of their plasticity, teleostean Igs are more diverse, and thus do not conform to mammalian classifications. Because of this, mammalian-based Ig cell markers cannot be used successfully to study immune responses in fish. There is therefore a need to produce Ig-specific cell ...
DOI:: 10.1016/j.fsi.2016.11.023
: https://doi.org/10.1016/j.fsi.2016.11.023

25. Characterization of immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution

Author:: Carolina S. Andreotti; Celina Baravalle; Sofía C. Sacco; Melisa Lovato; Elizabet A.L. Pereyra; María S. Renna; Hugo H. Ortega; Luis F. Calvinho; Bibiana E. Dallard
Source:: Comparative immunology, microbiology, and infectious diseases 2017 v.54 pp. 51-60
ISSN:: 0147-9571
Subject:: B-lymphocytes; Holstein; Staphylococcus aureus; T-lymphocytes; Toll-like receptor 2; Toll-like receptor 4; adaptive immunity; chronic diseases; cows; disease control; immune response; immunohistochemistry; interleukin-17; lactoferrin; late lactation; mammary glands; milking; protein synthesis; tumor necrosis factor-alpha
Abstract:: ... The aim of this study was to characterize the immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution. Twenty-one Holstein non-pregnant cows in late lactation either uninfected or with chronic naturally acquired S. aureus intramammary infections (IMI) were included in this study. Cows were slaughtered at 7, 14 and 21 d after cessation of milking ...
DOI:: 10.1016/j.cimid.2017.08.005
: https://doi.org/10.1016/j.cimid.2017.08.005

26. Characterization of major histocompatibility complex class I, and class II DRB loci of captive and wild Indian leopards (Panthera pardus fusca)

Author:: Drashti R. Parmar; Siuli Mitra; Snehalata Bhadouriya; Tirupathi Rao; Vaishnavi Kunteepuram; Ajay Gaur
Source:: Genetica 2017 v.145 no.6 pp. 541-558
ISSN:: 0016-6707
Subject:: Panthera pardus; adaptive immunity; alleles; amino acids; antigens; disease outbreaks; genetic variation; loci; major histocompatibility complex; phylogeny; receptors; vertebrates
Abstract:: ... The major histocompatibility complex (MHC), in vertebrate animals, is a multi-genic protein complex that encodes various receptors. During a disease, MHC interacts with the antigen and triggers a cascade of adaptive immune responses to overcome a disease outbreak. The MHC is very important region from immunological point of view, but it is poorly characterized among Indian leopards. During this in ...
DOI:: 10.1007/s10709-017-9979-5
: https://doi.org/10.1007/s10709-017-9979-5

27. Characterization of peritoneal leukemia-associated macrophages in Notch1-induced mouse T cell acute lymphoblastic leukemia

Author:: Shayan Chen; Xiao Yang; Wenli Feng; Feifei Yang; Rong Wang; Chong Chen; Lina Wang; Yongmin Lin; Qian Ren; Guoguang Zheng
Source:: Molecular Immunology 2017 v.81 pp. 35-41
ISSN:: 0161-5890
Subject:: T-lymphocytes; adaptive immunity; gene expression; genes; inducible nitric oxide synthase; lymphocytic leukemia; macrophages; mice; models; phenotype; spleen; transforming growth factor beta 1; vascular endothelial growth factor A
Abstract:: ... Macrophages, which have remarkable plasticity, are indispensable cellular components and play essential roles in both innate and adaptive immune responses. Peritoneal macrophages show unique gene expression profile and peritoneal cavity is also involved in leukemia. However, the characteristics of peritoneal leukemia-associated macrophages (Per LAMs) have not been established. Here we studied the ...
DOI:: 10.1016/j.molimm.2016.11.014
: https://doi.org/10.1016/j.molimm.2016.11.014

28. Characterization, expression, and evolutionary analysis of new TLR3 and TLR5M genes cloned from the spiny eel Mastacembelus armatus

Author:: Chong Han; Qiang Li; Zhipeng Zhang; Jianrong Huang
Source:: Developmental and comparative immunology 2017 v.77 pp. 174-187
ISSN:: 0145-305X
Subject:: Mastacembelus armatus; Toll-like receptor 3; Vibrio parahaemolyticus; adaptive immunity; amphibians; coevolution; eel; liver; models; pathogens; reptiles; spleen; tissues
Abstract:: ... Toll-like receptors (TLRs) play an important role in innate and adaptive immunity. Here, we identify two new TLRs from the spiny eel Mastacembelus armatus (TLR3 and membrane TLR5M). Both MaTLR3 and MaTLR5M were expressed in all tested tissues; expression was highest in liver and spleen, respectively. After infection with Vibrio parahaemolyticus, expression of both TLRs fluctuated and differed sign ...
DOI:: 10.1016/j.dci.2017.08.007
: https://doi.org/10.1016/j.dci.2017.08.007

29. Characterize a typically Dscam with alternative splicing in mud crab Scylla paramamosain

Author:: Wenshi Li; Xixiang Tang; Yan Chen; Wanwei Sun; Yan Liu; Yi Gong; Xiaobo Wen; Shengkang Li
Source:: Fish & shellfish immunology 2017 v.71 pp. 305-318
ISSN:: 1050-4648
Subject:: Down syndrome; Scylla paramamosain; Vibrio parahaemolyticus; adaptive immunity; alternative splicing; amino acids; antibodies; arthropods; binding capacity; brain; cell adhesion molecules; complementary DNA; crabs; exons; fibronectins; heart; hemolymph; hepatopancreas; immunoglobulins; innate immunity; intestines; muscles; open reading frames; pathogens; quantitative polymerase chain reaction
Abstract:: ... As a member of the immunoglobulin superfamily, Down syndrome cell adhesion molecule (Dscam) could function in the innate immunity of invertebrates. Recently, it is shown that arthropod Dscams play similar functions as antibodies in the adaptive immune system. Dscam could produce thousands of isoforms by alternative splicing and specifically bind to various pathogens. In the present study, we clone ...
DOI:: 10.1016/j.fsi.2017.10.023
: https://doi.org/10.1016/j.fsi.2017.10.023

30. Chromatographic and mass spectrometry analysis of wheat flour prolamins, the causative compounds of celiac disease

Author:: M. R. Perez-Gregorio; R. Días; N. Mateus; V. de Freitas
Source:: Food & function 2017 v.8 no.8 pp. 2712-2721
ISSN:: 2042-650X
Subject:: Western blotting; adaptive immunity; celiac disease; enzyme-linked immunosorbent assay; epitopes; gliadin; glutenins; high performance liquid chromatography; peptides; prolamins; proteomics; tandem mass spectrometry; wheat flour; wheat gluten; wheat protein
Abstract:: ... Immunogenic gluten peptides trigger Celiac Disease (CD), an adaptive immune response in genetically predisposed individuals. Given the structural similarity between all gluten proteins their individual CD influence is not clear. Hence, the extraction, separation and characterization of wheat gluten proteins have become relevant to measure their individual potential immunoreactivity. Wheat proteins ...
DOI:: 10.1039/c7fo00266a
: https://doi.org/10.1039/c7fo00266a

31. Cloning and functional characterization of IRAK4 in large yellow croaker (Larimichthys crocea) that associates with MyD88 but impairs NF-κB activation

Author:: Peng Fei Zou; Xue Na Huang; Cui Luan Yao; Qing Xue Sun; Ying Li; Qian Zhu; Zhen Xing Yu; Ze Jun Fan
Source:: Fish & shellfish immunology 2017 v.63 pp. 452-464
ISSN:: 1050-4648
Subject:: transcription factor NF-kappa B; liver; fluorescence microscopy; protein kinases; interleukins; muscles; adaptive immunity; signal transduction; Larimichthys crocea; spleen; cytoplasm; Vibrio parahaemolyticus; exons; fish; immune response; blood; introns; Toll-like receptors
Abstract:: ... As crucial signaling transducer in Toll-like receptor (TLR) and interleukin (IL)-1 receptor (IL-1R) signaling pathway, IL-1R-associated kinase 4 (IRAK4) mediates downstream signaling cascades and plays important roles in innate and adaptive immune responses. In the present study, an IRAK4 orthologue was characterized from large yellow croaker (Larimichthys crocea), named Lc-IRAK4, with a conservat ...
DOI:: 10.1016/j.fsi.2016.12.019
: https://doi.org/10.1016/j.fsi.2016.12.019

32. Cloning, characterization, and function of MyD88 in silvery pomfret (Pampus argenteus) in response to bacterial challenge

Author:: Quanxin Gao; Fei Yin; Chenjie Zhang; Yanfeng Yue; Peng Sun; Minghua Min; Shiming Peng; Zhaohong Shi; Jing Lv
Source:: International journal of biological macromolecules 2017 pp. -
ISSN:: 0141-8130
Subject:: Bramidae; Pampus argenteus; Toll-like receptor 2; Toll-like receptor 4; adaptive immunity; amino acid sequences; apoptosis; bacteria; complementary DNA; messenger RNA; open reading frames; phylogeny; probiotics; reverse transcriptase polymerase chain reaction; sequence alignment; signal transduction; transcription (genetics)
Abstract:: ... Myeloid differentiation factor 88 (MyD88) is a key and universal downstream adapter for most Toll-like receptors (TLRs) and plays an important role in both the innate and adaptive immune response. In this study, the full-length cDNA of MyD88 (PAMyD88) from silvery pomfret (Pampus argenteus) was cloned and characterized. The PAMyD88 cDNA is 1545bp in length and contains an 876bp open reading frames ...
DOI:: 10.1016/j.ijbiomac.2017.05.039
: https://doi.org/10.1016/j.ijbiomac.2017.05.039

33. Coccinia grandis (L.) Voigt Leaf Extract Exhibits Antileishmanial Effect Through Pro-inflammatory Response: An In Vitro Study

Author:: Asmita Pramanik; Dibyendu Paik; Kshudiram Naskar; Tapati Chakraborti
Source:: Current microbiology 2017 v.74 no.1 pp. 59-67
ISSN:: 0343-8651
Subject:: Coccinia grandis; Leishmania donovani; adaptive immunity; anti-infective agents; antiparasitic properties; cytotoxicity; humans; immunomodulators; inflammation; inhibitory concentration 50; interleukin-10; interleukin-12; leaf extracts; macrophages; mice; models; nitric oxide; parasite load; parasites; proteinase inhibitors; reactive oxygen species; serine proteinases; transforming growth factor beta; tumor necrosis factor-alpha; visceral leishmaniasis
Abstract:: ... The conventional drugs used for the treatment of human visceral leishmaniasis have concerns about the toxicity and most importantly parasite resistance. To overcome these troubles, more efforts are made for the development of innovative therapeutic agents having effective antileishmanial activity and simultaneously stimulate adaptive immune system of host cells. Hence, search for new leishmanicida ...
DOI:: 10.1007/s00284-016-1151-4
: https://doi.org/10.1007/s00284-016-1151-4

34. Comparative analysis of CRISPR‐Cas systems in Klebsiella genomes

Author:: Juntao Shen; Li Lv; Xudong Wang; Zhilong Xiu; Guoqiang Chen
Source:: Journal of basic microbiology 2017 v.57 no.4 pp. 325-336
ISSN:: 0233-111X
Subject:: Klebsiella pneumoniae; adaptive immunity; bacteria; cross infection; essential genes; plasmids; secondary infection
Abstract:: ... Prokaryotic CRISPR‐Cas system provides adaptive immunity against invasive genetic elements. Bacteria of the genus Klebsiella are important nosocomial opportunistic pathogens. However, information of CRISPR‐Cas system in Klebsiella remains largely unknown. Here, we analyzed the CRISPR‐Cas systems of 68 complete genomes of Klebsiella representing four species. All the elements for CRISPR‐Cas system ...
DOI:: 10.1002/jobm.201600589
: https://doi.org/10.1002/jobm.201600589

35. Comparative and temporal transcriptome analysis of peste des petits ruminants virus infected goat peripheral blood mononuclear cells

Author:: Siddappa Manjunath; Bishnu Prasad Mishra; Bina Mishra; Aditya Prasad Sahoo; Ashok K. Tiwari; Kaushal Kishore Rajak; D. Muthuchelvan; Shikha Saxena; Lakshman Santra; Amit Ranjan Sahu; Sajad Ahmad Wani; R.P. Singh; Y.P. Singh; Aruna Pandey; Sonam Kanchan; R.K. Singh; Gandham Ravi Kumar; Sarath Chandra Janga
Source:: Virus research 2017 v.229 pp. 28-40
ISSN:: 0168-1702
Subject:: goats; signal transduction; genes; vaccination; mononuclear leukocytes; interferons; adaptive immunity; cytokines; gene expression; viruses; gene expression regulation; temporal variation; transcriptomics; Small ruminant morbillivirus; immune response; interferon regulatory factors; peste des petits ruminants; quantitative polymerase chain reaction; complement; innate immunity; sheep; vaccines; inflammation; reverse transcriptase polymerase chain reaction; India
Abstract:: ... Peste des petits ruminanats virus (PPRV), a morbillivirus causes an acute, highly contagious disease – peste des petits ruminants (PPR), affecting goats and sheep. Sungri/96 vaccine strain is widely used for mass vaccination programs in India against PPR and is considered the most potent vaccine providing long-term immunity. However, occurrence of outbreaks due to emerging PPR viruses may be a cha ...
DOI:: 10.1016/j.virusres.2016.12.014
: https://doi.org/10.1016/j.virusres.2016.12.014

36. Comparative genomic and phylogenetic analysis of a toxigenic clinical isolate of Corynebacterium diphtheriae strain B-D-16-78 from Malaysia

Author:: Kar-Wai Hong; A.W. Asmah Hani; C.A. Nurul Aina Murni; R.R. Pusparani; Chee Kheong Chong; Khebir Verasahib; Wan Noraini W. Yusoff; Noorliza M. Noordin; Kok Keng Tee; Wai-Fong Yin; Choo Yee Yu; Geik Yong Ang; Kok-Gan Chan
Source:: Infection, genetics, and evolution 2017 v.54 pp. 263-270
ISSN:: 1567-1348
Subject:: Corynebacterium diphtheriae; DNA; adaptive immunity; chromosomes; genes; genetic relationships; genomics; herd immunity; monitoring; nucleotide sequences; phylogeny; toxigenic strains; Malaysia
Abstract:: ... In this study, we report the comparative genomics and phylogenetic analysis of Corynebacterium diphtheriae strain B-D-16-78 that was isolated from a clinical specimen in 2016. The complete genome of C. diphtheriae strain B-D-16-78 was sequenced using PacBio Single Molecule, Real-Time sequencing technology and consists of a 2,474,151-bp circular chromosome with an average GC content of 53.56%. The ...
DOI:: 10.1016/j.meegid.2017.07.015
: https://doi.org/10.1016/j.meegid.2017.07.015

37. Compartmentalized antimicrobial defenses in response to flagellin

Author:: Aneesh VIJAYAN; Martin RUMBO; Christophe CARNOY; Jean-Claude SIRARD
Source:: Trends in microbiology 2017 pp. -
ISSN:: 0966-842X
Subject:: CD4-positive T-lymphocytes; Toll-like receptor 5; adaptive immunity; bacteria; dendritic cells; epithelial cells; flagellin; flagellum; innate immunity; mucosa; niches; pathogenicity; pathogens
Abstract:: ... Motility is often a pathogenicity determinant of bacteria targeting mucosal tissues. Flagella constitute the machinery that propels bacteria into appropriate niches. Besides motility, the structural component flagellin, which forms flagella, targets Toll-like receptor 5 (TLR5) to activate innate immunity. The compartmentalization of flagellin-mediated immunity and the contribution of epithelial ce ...
DOI:: 10.1016/j.tim.2017.10.008
: https://doi.org/10.1016/j.tim.2017.10.008

38. Complement factor H in host defense and immune evasion

Author:: Raffaella Parente; Simon J. Clark; Antonio Inforzato; Anthony J. Day
Source:: Cellular and molecular life sciences 2017 v.74 no.9 pp. 1605-1624
ISSN:: 1420-682X
Subject:: adaptive immunity; complement; cytotoxicity; homeostasis; immune evasion; immune response; infectious diseases; innate immunity; macular degeneration; mutation; neoplasm cells; neoplasms; pathogens; pathophysiology
Abstract:: ... Complement is the major humoral component of the innate immune system. It recognizes pathogen- and damage-associated molecular patterns, and initiates the immune response in coordination with innate and adaptive immunity. When activated, the complement system unleashes powerful cytotoxic and inflammatory mechanisms, and thus its tight control is crucial to prevent damage to host tissues and allow ...
DOI:: 10.1007/s00018-016-2418-4
PubMed:: 27942748
PubMed Central:: PMC5378756
: https://doi.org/10.1007/s00018-016-2418-4

39. Complement’s hidden arsenal: New insights and novel functions inside the cell

Author:: M. Kathryn Liszewski; Michelle Elvington; Hrishikesh S. Kulkarni; John P. Atkinson
Source:: Molecular Immunology 2017 pp. -
ISSN:: 0161-5890
Subject:: T-lymphocytes; adaptive immunity; complement; immune response; pathogens; protein secretion; receptors; therapeutics
Abstract:: ... A key component of both innate and adaptive immunity, new understandings of the complement system are expanding its roles beyond that traditionally appreciated. Evidence is accumulating that complement has an intracellular arsenal of components that provide not only immune defense, but also assist in key interactions for host cell functions. Although early work has primarily centered on T cells, t ...
DOI:: 10.1016/j.molimm.2017.01.004
PubMed:: 28196665
PubMed Central:: PMC5373558
: https://doi.org/10.1016/j.molimm.2017.01.004

40. Comprehensive understanding of PM2.5 on gene and microRNA expression patterns in zebrafish (Danio rerio) model

Author:: Junchao Duan; Yang Yu; Yang Li; Li Jing; Man Yang; Ji Wang; Yanbo Li; Xianqing Zhou; Mark R. Miller; Zhiwei Sun
Source:: Science of the total environment 2017 v.586 pp. 666-674
ISSN:: 0048-9697
Subject:: Danio rerio; adaptive immunity; atherosclerosis; autophagy; cytochrome P-450; dose response; fish; gene expression regulation; genes; humans; hypertension; metabolism; microRNA; models; myocardial infarction; neoplasms; particulates; public health; toxicity; transcription (genetics); vasodilation; xenobiotics
Abstract:: ... PM2.5 is a major public health concern and some severe diseases have been attributed to exposure to PM2.5. However, a comprehensive understanding of gene and microRNA expression patterns induced by PM2.5 is missing. The objective of this study was to evaluate the toxicity of PM2.5 via genome-wide transcriptional analysis in the model teleost fish, zebrafish (Danio rerio). Gene ontology analysis re ...
DOI:: 10.1016/j.scitotenv.2017.02.042
: https://doi.org/10.1016/j.scitotenv.2017.02.042

41. Convergent evolution of the adaptive immune response in jawed vertebrates and cyclostomes: An evolutionary biology approach based study

Author:: Jose Ricardo Morales Poole; Julien Paganini; Pierre Pontarotti
Source:: Developmental and comparative immunology 2017 v.75 pp. 120-126
ISSN:: 0145-305X
Subject:: B-lymphocytes; T-lymphocytes; adaptive immunity; convergent evolution; enzymes; vertebrates
Abstract:: ... Two different adaptive immune systems (AIS) are present in the two phyla of vertebrates (jawed vertebrates and cyclostomes). The jawed vertebrate system is based on IG/TCR/RAG/MHC while the cyclostome system is based on VLRCs and AID-like enzymes both systems using homologous Cell types (B-cell and B-cell Like, T-cell and T-cell like).We will present our current view of the evolution of these two ...
DOI:: 10.1016/j.dci.2017.02.011
: https://doi.org/10.1016/j.dci.2017.02.011

42. Coupling immunity and programmed cell suicide in prokaryotes: Life‐or‐death choices

Author:: Eugene V. Koonin; Feng Zhang
Source:: BioEssays 2017 v.39 no.1 pp. 1-9
ISSN:: 0265-9247
Subject:: Archaea; RNA; adaptive immunity; apoptosis; bacteria; dormancy; evolution; genes; parasites; prokaryotic cells; proteins; reproduction; suicide
Abstract:: ... Host‐pathogen arms race is a universal, central aspect of the evolution of life. Most organisms evolved several distinct yet interacting strategies of anti‐pathogen defense including resistance to parasite invasion, innate and adaptive immunity, and programmed cell death (PCD). The PCD is the means of last resort, a suicidal response to infection that is activated when resistance and immunity fail ...
DOI:: 10.1002/bies.201600179
PubMed:: 28004447
PubMed Central:: PMC5319824
: https://doi.org/10.1002/bies.201600179

43. Cow's milk and rice fermented with Lactobacillus paracasei CBA L74 prevent infectious diseases in children: A randomized controlled trial

Author:: Rita Nocerino; Lorella Paparo; Gianluca Terrin; Vincenza Pezzella; Antonio Amoroso; Linda Cosenza; Gaetano Cecere; Giulio De Marco; Maria Micillo; Fabio Albano; Rosa Nugnes; Pasqualina Ferri; Giuseppe Ciccarelli; Giuliana Giaccio; Raffaella Spadaro; Ylenia Maddalena; Francesco Berni Canani; Roberto Berni Canani
Source:: Clinical nutrition 2017 v.36 pp. 118-125
ISSN:: 0261-5614
Subject:: Lactobacillus paracasei; adaptive immunity; biomarkers; cathelicidins; children; fermented foods; gastroenteritis; immunoglobulin A; infectious diseases; males; milk; pediatricians; placebos; randomized clinical trials; respiratory tract diseases; rice; winter
Abstract:: ... Fermented foods have been proposed for the prevention of infectious diseases. We evaluated the efficacy of fermented foods in reducing common infectious diseases (CIDs) in children attending daycare.Prospective randomized, double-blind, placebo-controlled trial (registered under Clinical Trials.gov identifier NCT01909128) on healthy children (aged 12–48 months) consuming daily cow's milk (group A) ...
DOI:: 10.1016/j.clnu.2015.12.004
: https://doi.org/10.1016/j.clnu.2015.12.004

44. CpG ODN 1668 induce innate and adaptive immune responses in rock bream (Oplegnathus fasciatus) against rock bream iridovirus (RBIV) infection

Author:: Myung-Hwa Jung; Sung-Ju Jung
Source:: Fish & shellfish immunology 2017 v.69 pp. 247-257
ISSN:: 1050-4648
Subject:: Oplegnathus fasciatus; Rock bream iridovirus; adaptive immunity; bream; caspases; cell death; gene expression regulation; genes; immune response; innate immunity; interleukin-1beta; ligands; mortality; oligodeoxyribonucleotides; viral load; viruses; Korean Peninsula
Abstract:: ... Rock bream iridovirus (RBIV) causes severe mass mortalities in rock bream in Korea. CpG ODN 1668 showed promise as immunoprotective agents against RBIV infection in rock bream. In this study, we assessed innate/adaptive-related gene expression patterns in RBIV-infected rock bream with and without CpG ODN 1668 administration to determine important immune defense related factors that may affect fish ...
DOI:: 10.1016/j.fsi.2017.08.030
: https://doi.org/10.1016/j.fsi.2017.08.030

45. Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1

Author:: Stamogiannos Athanasios; Maben Zachary; Papakyriakou Athanasios; Mpakali Anastasia; Kokkala Paraskevi; Georgiadis Dimitris; Stern Lawrence J.; Stratikos Efstratios
Source:: Biochemistry 2017 v.56 no.10 pp. 1546-1558
ISSN:: 1520-4995
Subject:: X-radiation; X-ray diffraction; active sites; adaptive immunity; aminopeptidases; catalytic activity; dissociation; electrostatic interactions; endoplasmic reticulum; epitopes; molecular dynamics; peptides; site-directed mutagenesis
Abstract:: ... Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an intracellular enzyme that is important for the generation of antigenic epitopes and major histocompatibility class I-restricted adaptive immune responses. ERAP1 processes a vast variety of different peptides but still shows length and sequence selectivity, although the mechanism behind these properties is poorly understood. X-ray crystallographi ...
DOI:: 10.1021/acs.biochem.6b01170
PubMed:: 28218509
PubMed Central:: PMC6374128
: https://doi.org/10.1021/acs.biochem.6b01170

46. Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex

Author:: Tai Wei Guo; Alberto Bartesaghi; Hui Yang; Veronica Falconieri; Prashant Rao; Alan Merk; Edward T. Eng; Ashleigh M. Raczkowski; Tara Fox; Lesley A. Earl; Dinshaw J. Patel; Sriram Subramaniam
Source:: Cell 2017 v.171 pp. 414-426.e12
ISSN:: 0092-8674
Subject:: DNA; RNA; RNA interference; Yersinia; cryo-electron microscopy; gene editing; immune system; monitoring; prokaryotic cells; viruses
Abstract:: ... Prokaryotic cells possess CRISPR-mediated adaptive immune systems that protect them from foreign genetic elements, such as invading viruses. A central element of this immune system is an RNA-guided surveillance complex capable of targeting non-self DNA or RNA for degradation in a sequence- and site-specific manner analogous to RNA interference. Although the complexes display considerable diversity ...
DOI:: 10.1016/j.cell.2017.09.006
PubMed:: 28985564
PubMed Central:: PMC5683424
: https://doi.org/10.1016/j.cell.2017.09.006

47. DNA Vaccination Partially Protects Muskellunge against Viral Hemorrhagic Septicemia Virus (VHSV‐IVb)

Author:: Elena V. Millard; Ashley M. Bourke; Scott E. LaPatra; Travis O. Brenden; Scott D. Fitzgerald; Mohamed Faisal
Source:: Journal of aquatic animal health 2017 v.29 no.1 pp. 50-56
ISSN:: 0899-7659
Subject:: Esox masquinongy; Infectious hematopoietic necrosis virus; Oncorhynchus mykiss; Viral hemorrhagic septicemia virus; adaptive immunity; fish; genes; genotype; glycoproteins; heat sums; immune response; neutralizing antibodies; plasmids; recombinant vaccines; vaccination; vaccine development; viral load
Abstract:: ... A DNA vaccine containing the glycoprotein (G) gene of the North American viral hemorrhagic septicemia virus (VHSV) genotype IVb was developed to evaluate the immune response of fish following vaccination and evaluate its efficacy in protecting a susceptible species, the Muskellunge Esox masquinongy, against VHSV‐IVb challenge. Seven weeks (539 degree‐days) following vaccination with 10 μg of eithe ...
DOI:: 10.1080/08997659.2016.1238413
: https://doi.org/10.1080/08997659.2016.1238413

48. Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation

Author:: Nicola Manfrini; Sara Ricciardi; Annarita Miluzio; Maya Fedeli; Alessandra Scagliola; Simone Gallo; Thure Adler; Dirk H. Busch; Valerie Gailus-Durner; Helmut Fuchs; Martin Hrabě de Angelis; Stefano Biffo
Source:: Data in Brief 2017 v.14 pp. 653-658
ISSN:: 2352-3409
Subject:: adaptive immunity; biogenesis; flow cytometry; glycolysis; homeostasis; thymocytes
Abstract:: ... The data described in this article are related to “High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4⁺ T cells in both mice and humans” (Manfrini et al., in press) [1]. eIF6 is a translation initiation factor required for ribosomal biogenesis (Sanvito et al., 1999) [2] and for proper translation ...
DOI:: 10.1016/j.dib.2017.08.023
: https://doi.org/10.1016/j.dib.2017.08.023

49. Deciphering antigen-responding antibody repertoires by using next-generation sequencing and confirming them through antibody-gene synthesis

Author:: Naoko Kono; Lin Sun; Hiroyuki Toh; Takeyuki Shimizu; Hanbing Xue; Osamu Numata; Manabu Ato; Kazuo Ohnishi; Shigeyuki Itamura
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: adaptive immunity; antibodies; antigens; chickens; enzyme-linked immunosorbent assay; gamma-globulins; high-throughput nucleotide sequencing; immunoglobulin G; immunoglobulin M; mice; models
Abstract:: ... Vast diversity and high specificity of antigen recognition by antibodies are hallmarks of the acquired immune system. Although the molecular mechanisms that yield the extremely large antibody repertoires are precisely understood, comprehensive description of the global antibody repertoire generated in individual bodies has been hindered by the lack of powerful measures. To obtain holistic understa ...
DOI:: 10.1016/j.bbrc.2017.04.054
: https://doi.org/10.1016/j.bbrc.2017.04.054

50. Deciphering transcriptome profile of the yellow catfish (Pelteobagrus fulvidraco) in response to Edwardsiella ictaluri

Author:: Rong Zhu; Xiao-Xiao Liu; Xue Lv; Shun-Yi Li; Ya-Dong Li; Xue-Jing Yu; Xing-Guo Wang
Source:: Fish & shellfish immunology 2017 v.70 pp. 593-608
ISSN:: 1050-4648
Subject:: B-lymphocytes; Edwardsiella ictaluri; T-lymphocytes; Tachysurus fulvidraco; adaptive immunity; aquaculture; coagulation; complement; disease control programs; fish; gene expression; gene expression regulation; genes; microsatellite repeats; pathogens; signal transduction; transcriptomics; China
Abstract:: ... Edwardsiella ictaluri is one of the most important pathogens posing a serious threat for yellow catfish (Pelteobagrus fulvidraco), a highly valuable fish species of increasing commercial interest in China. Here, a transcriptomic strategy was undertaken to investigate the yellow catfish gene expression profile against infection by the bacterial pathogen E. ictaluri. Comparison of the transcriptome ...
DOI:: 10.1016/j.fsi.2017.08.040
: https://doi.org/10.1016/j.fsi.2017.08.040

51. Decreased vaccine antibody titers following exposure to multiple metals and metalloids in e-waste-exposed preschool children

Author:: Xinjiang Lin; Xijin Xu; Xiang Zeng; Long Xu; Zhijun Zeng; Xia Huo
Source:: Environmental pollution 2017 v.220 pp. 354-363
ISSN:: 0269-7491
Subject:: adaptive immunity; antibodies; arsenic; blood; body mass index; cadmium; chromium; chronic exposure; copper; electronic wastes; encephalitis; heavy metals; hepatitis B; lead; manganese; measles; mercury; nickel; preschool children; recycling; regression analysis; risk factors; selenium; tetanus; vaccination; vaccines; zinc; China
Abstract:: ... We explored acquired immunity resulting from vaccination in 3 to 7-year-old children, chronically exposed to multiple heavy metals and metalloids, in an e-waste recycling area (Guiyu, China). Child blood levels of ten heavy metals and metalloids, including lead (Pb), arsenic (As), mercury (Hg), chromium (Cr), cadmium (Cd), manganese (Mn), nickel (Ni), copper (Cu), zinc (Zn) and selenium (Se), and ...
DOI:: 10.1016/j.envpol.2016.09.071
: https://doi.org/10.1016/j.envpol.2016.09.071

52. Delivering adjuvants and antigens in separate nanoparticles eliminates the need of physical linkage for effective vaccination

Author:: Mona O. Mohsen; Ariane C. Gomes; Gustavo Cabral-Miranda; Caroline C. Krueger; Fabiana MS Leoratti; Jens V. Stein; Martin F. Bachmann
Source:: Journal of Controlled Release 2017 pp. -
ISSN:: 0168-3659
Subject:: DNA; Toll-like receptor 9; adaptive immunity; adjuvants; antigens; cytokines; dendritic cells; deoxyribonucleases; endosomes; immune response; immunostimulants; lymph nodes; macrophages; medicine; nanoparticles; vaccination; virus-like particle vaccines; virus-like particles
Abstract:: ... DNA rich in unmethylated CG motifs (CpGs) engage Toll-Like Receptor 9 (TLR-9) in endosomes and are well described stimulators of the innate and adaptive immune system. CpGs therefore can efficiently improve vaccines' immunogenicity. Packaging CpGs into nanoparticles, in particular into virus-like particles (VLPs), improves the pharmacological characteristics of CpGs as the protein shell protects t ...
DOI:: 10.1016/j.jconrel.2017.02.031
: https://doi.org/10.1016/j.jconrel.2017.02.031

53. Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications

Author:: Chang Liu; Li Zhang; Hao Liu; Kun Cheng
Source:: Journal of Controlled Release 2017 pp. -
ISSN:: 0168-3659
Subject:: Archaea; RNA; T-lymphocytes; adaptive immunity; bacteria; bacteriophages; clinical trials; eukaryotic cells; genes; genetic engineering; humans; immunotherapy; mutation; neoplasms; patients; plasmids
Abstract:: ... The CRISPR-Cas9 genome-editing system is a part of the adaptive immune system in archaea and bacteria to defend against invasive nucleic acids from phages and plasmids. The single guide RNA (sgRNA) of the system recognizes its target sequence in the genome, and the Cas9 nuclease of the system acts as a pair of scissors to cleave the double strands of DNA. Since its discovery, CRISPR-Cas9 has becom ...
DOI:: 10.1016/j.jconrel.2017.09.012
PubMed:: 28911805
PubMed Central:: PMC5723556
: https://doi.org/10.1016/j.jconrel.2017.09.012

54. Dendritic cell harmonised immunity to poultry pathogens; a review

Author:: Z.U. REHMAN; S. UMAR; C. MENG; Z. ULLAH; F. RIAZ; S.U. REHMAN; C. DING
Source:: World's poultry science journal 2017 v.73 no.3 pp. 581-590
ISSN:: 1743-4777
Subject:: adaptive immunity; bacteria; chickens; dendritic cells; fungi; immune response; innate immunity; parasites; pathogens; vaccination; vaccine development; viruses
Abstract:: ... Dendritic cells (DCs) are antigen-presenting cells (APCs) with the unique ability to induce both innate immune responses and a highly specific acquired immunity. DCs are crucial to induce immunity, and their maturation and functions are influenced by microbial and environmental stimuli. Chicken DCs are composed of several subtypes including bursal secretory dendritic cells (BSDCs), follicular dend ...
DOI:: 10.1017/S0043933917000496
: https://doi.org/10.1017/S0043933917000496

55. Dendritic cells during mousepox: The role of delayed apoptosis in the pathogenesis of infection

Author:: Piotr Orlowski; Maja Pardecka; Joanna Cymerys; Malgorzata Krzyzowska
Source:: Microbial pathogenesis 2017 v.109 pp. 99-109
ISSN:: 0882-4010
Subject:: Ectromelia virus; adaptive immunity; apoptosis; bone marrow; dendritic cells; immunosuppression; innate immunity; mice; mitochondria; pathogenesis; viruses
Abstract:: ... Dendritic cells (DCs) are effector cells linking the innate immune system with the adaptive immune response. Many viruses eliminate DCs to prevent host response, induce immunosuppression and to maintain chronic infection. In this study, we examined apoptotic response of dendritic cells during in vitro and in vivo infection with ectromelia virus (ECTV), the causative agent of mousepox. ECTV-infecte ...
DOI:: 10.1016/j.micpath.2017.05.037
: https://doi.org/10.1016/j.micpath.2017.05.037

56. Describing the diversity of Ag specific receptors in vertebrates: Contribution of repertoire deep sequencing

Author:: Rosario Castro; Sofie Navelsaker; Aleksei Krasnov; Louis Du Pasquier; Pierre Boudinot
Source:: Developmental and comparative immunology 2017 v.75 pp. 28-37
ISSN:: 0145-305X
Subject:: adaptive immunity; complementary DNA; developmental stages; evolution; fish; frogs; high-throughput nucleotide sequencing; invertebrates; loci; metamorphosis; multigene family; new species; pathogens; receptors; silver; vaccination; vaccines
Abstract:: ... During the last decades, gene and cDNA cloning identified TCR and Ig genes across vertebrates; genome sequencing of TCR and Ig loci in many species revealed the different organizations selected during evolution under the pressure of generating diverse repertoires of Ag receptors. By detecting clonotypes over a wide range of frequency, deep sequencing of Ig and TCR transcripts provides a new way to ...
DOI:: 10.1016/j.dci.2017.02.018
: https://doi.org/10.1016/j.dci.2017.02.018

57. Development of a monoclonal antibody against the CD3ε of olive flounder (Paralichthys olivaceus) and its application in evaluating immune response related to CD3ε

Author:: Jae Wook Jung; Jung Seok Lee; Young Rim Kim; Se Pyeong Im; Si Won Kim; Jassy Mary S. Lazarte; Jaesung Kim; Kim D. Thompson; Jong Pyo Suh; Tae Sung Jung
Source:: Fish & shellfish immunology 2017 v.65 pp. 179-185
ISSN:: 1050-4648
Subject:: Paralichthys olivaceus; T-lymphocytes; Viral hemorrhagic septicemia virus; Western blotting; adaptive immunity; antigens; binding sites; chemical elements; confocal microscopy; flounder; flow cytometry; immune response; liver; lymphocyte count; monoclonal antibodies; polyacrylamide gel electrophoresis; recombinant proteins; reverse transcriptase polymerase chain reaction; spleen; yeasts
Abstract:: ... The T cell receptor (TCR) is the binding site of antigen and is responsible for specifically activating the adaptive immune response. CD3, an essential component of the CD3-TCR complex, is known to be composed of γδ and ε chains in teleost. However, there are few monoclonal antibodies (mAb) available to identify these molecules on T cells, so we aimed to produce a mAb against CD3ε to improve our u ...
DOI:: 10.1016/j.fsi.2017.04.016
: https://doi.org/10.1016/j.fsi.2017.04.016

58. Development, phenotype, and function of non-conventional B cells

Author:: J.M.B. Prieto; M.J.B. Felippe
Source:: Comparative immunology, microbiology, and infectious diseases 2017 v.54 pp. 38-44
ISSN:: 0147-9571
Subject:: B-lymphocytes; Primates; adaptive immunity; autoimmune diseases; cattle; functional properties; guinea pigs; homeostasis; horses; humans; immunoglobulin M; innate immunity; mice; phenotype; rabbits; secretion; swine; tissue distribution
Abstract:: ... Three populations of B cells develop in fetal life: B1, B2 and marginal zone B cells. B1 cells play important roles in innate immunity in contrast to B2 cells that perform the conventional roles in adaptive immunity. B1 cells were first identified in mice based on their expression of CD5 and spontaneous secretion of IgM. B1 cells were subsequently found to have unique developmental, phenotype, tis ...
DOI:: 10.1016/j.cimid.2017.08.002
: https://doi.org/10.1016/j.cimid.2017.08.002

59. Differences in expression of genes in the MyD88 and TRIF signalling pathways and methylation of TLR4 and TRIF in Tibetan chickens and DaHeng S03 chickens infected with Salmonella enterica serovar enteritidis

Author:: Xiaocheng Li; Peng Zhang; Xiaosong Jiang; Huarui Du; Chaowu Yang; Zengrong Zhang; Shuai Men; Zhikun Zhang; Wei Jiang; Hongning Wang
Source:: Veterinary immunology and immunopathology 2017 v.189 pp. 28-35
ISSN:: 0165-2427
Subject:: Salmonella Enteritidis; Toll-like receptor 4; adaptive immunity; bacteria; breeds; chickens; death; financial economics; foodborne illness; gene expression; genes; interleukin-8; messenger RNA; methylation; signal transduction
Abstract:: ... Salmonella enterica serovar (S. enteritidis) is a pathogenic bacterium that can cause symptoms of food poisoning, leading to death of poultry, resulting in serious economic losses. The MyD88 and TRIF signalling pathways play important roles in activating innate and adaptive immunity in chickens infected with S. enteritidis. The objective of the present study was to characterize in vivo mRNA expres ...
DOI:: 10.1016/j.vetimm.2017.05.003
: https://doi.org/10.1016/j.vetimm.2017.05.003

60. Differences in innate and adaptive immune response traits of Pahari (Indian non-descript indigenous breed) and Jersey crossbred cattle

Author:: Subhash Verma; Aneesh Thakur; Shailja Katoch; Chander Shekhar; Aasim Habib Wani; Sandeep Kumar; Shweta Dohroo; Geetanjali Singh; Mandeep Sharma
Source:: Veterinary immunology and immunopathology 2017 v.192 pp. 20-27
ISSN:: 0165-2427
Subject:: Jersey; adaptive immunity; breed differences; breeding; cattle; immune response; milk production; India
Abstract:: ... Cattle are an integral part of the largely agrarian economy of India. Indigenous breeds of cattle comprise about 80% of total cattle population of the country and contribute significantly to the overall milk production. There are 40 recognized indigenous breeds of cattle and a number of uncharacterized non-descript cattle. Pahari cattle of Himachal Pradesh in Northern India are one such non-descri ...
DOI:: 10.1016/j.vetimm.2017.09.003
: https://doi.org/10.1016/j.vetimm.2017.09.003

61. Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation

Author:: Ka Lung Cheung; Fan Zhang; Anbalagan Jaganathan; Rajal Sharma; Qiang Zhang; Tsuyoshi Konuma; Tong Shen; June-Yong Lee; Chunyan Ren; Chih-Hung Chen; Geming Lu; Matthew R. Olson; Weijia Zhang; Mark H. Kaplan; Dan R. Littman; Martin J. Walsh; Huabao Xiong; Lei Zeng; Ming-Ming Zhou
Source:: Molecular cell 2017 v.65 no.6 pp. 1068-1080.e5
ISSN:: 1097-2765
Subject:: CD4-positive T-lymphocytes; DNA-directed RNA polymerase; adaptive immunity; cell differentiation; chromatin; cyclins; drugs; genes; mice; phosphorylation; transcription (genetics); transcription factors; transcriptional activation
Abstract:: ... The BET proteins are major transcriptional regulators and have emerged as new drug targets, but their functional distinction has remained elusive. In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T helper 17 (Th17) cell differentiation. Brd2 is associated with the chromatin insulator CTCF ...
DOI:: 10.1016/j.molcel.2016.12.022
PubMed:: 28262505
PubMed Central:: PMC5357147
: https://doi.org/10.1016/j.molcel.2016.12.022

62. Diversity, classification and evolution of CRISPR-Cas systems

Author:: Eugene V Koonin; Kira S Makarova; Feng Zhang
Source:: Current opinion in microbiology 2017 v.37 pp. 67-78
ISSN:: 1369-5274
Subject:: RNA; adaptive immunity; evolution; genome; interspersed repetitive sequences; loci
Abstract:: ... The bacterial and archaeal CRISPR-Cas systems of adaptive immunity show remarkable diversity of protein composition, effector complex structure, genome locus architecture and mechanisms of adaptation, pre-CRISPR (cr)RNA processing and interference. The CRISPR-Cas systems belong to two classes, with multi-subunit effector complexes in Class 1 and single-protein effector modules in Class 2. Concerte ...
DOI:: 10.1016/j.mib.2017.05.008
PubMed:: 28605718
PubMed Central:: PMC5776717
: https://doi.org/10.1016/j.mib.2017.05.008

63. Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome?

Author:: Rebecca Devlin; Catarina A. Marques; Richard McCulloch
Source:: Current genetics 2017 v.63 no.3 pp. 441-449
ISSN:: 0172-8083
Subject:: DNA replication; adaptive immunity; antigenic variation; gene conversion; genes; glycoproteins; homologous recombination; immune evasion; models; pathogens; telomeres; transcription (genetics)
Abstract:: ... All pathogens must survive host immune attack and, amongst the survival strategies that have evolved, antigenic variation is a particularly widespread reaction to thwart adaptive immunity. Though the reactions that underlie antigenic variation are highly varied, recombination by gene conversion is a widespread approach to immune survival in bacterial and eukaryotic pathogens. In the African trypan ...
DOI:: 10.1007/s00294-016-0662-7
PubMed:: 27822899
PubMed Central:: PMC5422504
: https://doi.org/10.1007/s00294-016-0662-7

64. Downregulation of lizard immuno-genes in the regenerating tail and myogenes in the scarring limb suggests that tail regeneration occurs in an immuno-privileged organ

Author:: Nicola Vitulo; Luisa Dalla Valle; Tatjana Skobo; Giorgio Valle; Lorenzo Alibardi
Source:: Protoplasma 2017 v.254 no.6 pp. 2127-2141
ISSN:: 0033-183X
Subject:: adaptive immunity; amputation; evolution; extracellular matrix; gene expression regulation; genes; histology; immunoglobulins; inflammation; lizards; medicine; metabolism; muscle development; muscle protein; muscles; non-coding RNA; receptors; tail; transcriptome
Abstract:: ... Amputated tails of lizards regenerate while limbs form scars which histological structure is very different from the original organs. Lizards provide useful information for regenerative medicine and some hypotheses on the loss of regeneration in terrestrial vertebrates. Analysis of tail and limb transcriptomes shows strong downregulation in the tail blastema for immunoglobulins and surface B and T ...
DOI:: 10.1007/s00709-017-1107-y
: https://doi.org/10.1007/s00709-017-1107-y

65. Drosophilosophical: Re-thinking Adaptive Immunity in the Fly

Author:: Cara West; Neal Silverman
Source:: Cell 2017 v.169 pp. 188-190
ISSN:: 0092-8674
Subject:: Diptera; RNA interference; adaptive immunity; exosomes; innate immunity; mammals; models
Abstract:: ... For decades, flies have been a model for innate immunity. In this issue of Cell, Tassetto et al. describe a mechanism for antiviral RNAi spreading that parallels mammalian adaptive immunity through reverse-transcribed vDNA circles and the systemic dissemination of small-RNA-containing exosomes. ...
DOI:: 10.1016/j.cell.2017.03.032
: https://doi.org/10.1016/j.cell.2017.03.032

66. Dynamic interaction of neutrophils and RFP-labelled Vibrio parahaemolyticus in zebrafish (Danio rerio)

Author:: Qiuyue Zhang; An Ding; Qianwen Yue; Weiming Li; Yao Zu; Qinghua Zhang
Source:: Aquaculture and fisheries 2017 v.2 no.6 pp. 269-277
ISSN:: 2096-1758
Subject:: Danio rerio; Vibrio parahaemolyticus; adaptive immunity; blood circulation; caudal vein; chemotaxis; eyes; fish; genetic recombination; heart; host-pathogen relationships; hosts; injection site; larvae; lethal dose 50; models; neutrophils; pathogens; phagocytosis; red fluorescent protein; vibriosis; zoonoses
Abstract:: ... Vibrio parahaemolyticus (Vp) is an aquatic zoonotic pathogen that causes vibriosis in marine animals as well as sepsis, gastroenteritis and wound infection in human. In vertebrates, the innate immune system plays a critical defense mechanism against Vp infection including transmigration of neutrophils. In this study, we have examined the genetic recombination and infectious process of Vp in the ze ...
DOI:: 10.1016/j.aaf.2017.10.006
: https://doi.org/10.1016/j.aaf.2017.10.006

67. Early Immune Responses to Marek’s Disease Vaccines

Author:: MOHAMMAD HEIDARI; DAN WANG; SHUHONG SUN
Source:: Viral Immunology 2017 v.30 no.3 pp. 167-177
ISSN:: 1557-8976
Subject:: CD4-positive T-lymphocytes; Mardivirus; Marek disease; adaptive immunity; animal organs; antigens; cecum; chickens; disease resistance; duodenum; epithelium; gene expression; gene expression regulation; genes; immune response; immunohistochemistry; innate immunity; macrophages; peripheral nerves; tonsils; vaccination; vaccines; virulent strains; viruses
Abstract:: ... Marek’s disease virus (MDV), a highly cell-associated lymphotropic 'alpha-herpesvirus, is the causative agent of Marek’s disease (MD) in domestic chickens. MDV replicates in chicken lymphocytes and establishes a latent infection within CD4+ T cells. The latently infected CD4+ T cells carry the virus to visceral organs, peripheral nerves, and feather follicle epithelium (FFE). Although MD vaccines ...
Handle:: 10113/5700714
DOI:: 10.1089/vim.2016.0126
: https://doi.org/10.1089/vim.2016.0126

68. Early exposure to Batrachochytrium dendrobatidis causes profound immunosuppression in amphibians

Author:: Andrés Fernández-Loras; Saioa Fernández-Beaskoetxea; Elena Arriero; Matthew C. Fisher; Jaime Bosch
Source:: European journal of wildlife research 2017 v.63 no.6 pp. 99
ISSN:: 1612-4642
Subject:: Batrachochytrium dendrobatidis; adaptive immunity; blood serum; fungi; immune response; immunoglobulin M; immunoglobulin Y; immunosuppression; juveniles; lymphocytes; metamorphosis; neutrophils; pathogens; tadpoles; toads
Abstract:: ... Fungal pathogens have evolved a broad suite of strategies aiming at evading the host immune response. Amphibians are globally infected by the panzootic chytrid fungus Batrachochytrium dendrobatidis (Bd) and, while robust innate immune defences have been characterised, there is little evidence for the existence of effective adaptive immunity. We determine the immune response of the common midwife t ...
DOI:: 10.1007/s10344-017-1161-y
: https://doi.org/10.1007/s10344-017-1161-y

69. Echinacea pupurea extracts promote murine dendritic cell maturation by activation of JNK, p38 MAPK and NF-κB pathways

Author:: Yali Li; Yuanyuan Wang; Yanping Wu; Baikui Wang; Xi Chen; Xin Xu; Hongliang Chen; Weifen Li; Xiaogang Xu
Source:: Developmental and comparative immunology 2017 v.73 pp. 21-26
ISSN:: 0145-305X
Subject:: Echinacea purpurea; adaptive immunity; chemical elements; dendritic cells; gene expression regulation; interferon-gamma; interleukin-10; interleukin-12; mice; mitogen-activated protein kinase; phagocytosis; phenotype; transcription factor NF-kappa B; transforming growth factor beta 1
Abstract:: ... Dendritic cells (DCs) comprise a system of highly professional antigen presenting cells (APCs) which connect innate and adaptive immunity by undergoing dramatic shift in their maturation state. Phytomedicine Echinacea purpurea extracts (EE) could modulate murine dendritic cell fate and function. However, the underlying mechanism of EE on DCs development and maturation remains limited. In this stud ...
DOI:: 10.1016/j.dci.2017.03.002
: https://doi.org/10.1016/j.dci.2017.03.002

70. Effect of artificial rearing of piglets on the volume densities of M cells in the tonsils of the soft palate and ileal Peyer’s patches

Author:: S. Prims; N. Pintens; H. Vergauwen; S. Van Cruchten; C. Van Ginneken; C. Casteleyn
Source:: Veterinary immunology and immunopathology 2017 v.184 pp. 1-7
ISSN:: 0165-2427
Subject:: adaptive immunity; antigens; artificial rearing; brooders; colostrum; epithelial cells; epithelium; euthanasia; hybrids; ileum; immunohistochemistry; litter size; milk; milk replacer; neonates; oropharynx; palate; piglets; sows; tissue analysis; tonsils
Abstract:: ... The high prolificacy of modern hybrid sows has increased the mean litter size during the last decades. However, rearing large litters is challenging and has increased the use of alternative management strategies such as euthanasia of weak piglets, cross-fostering, supplementing piglets with milk, split-nursing and split-weaning. The latter includes artificial rearing on brooders where piglets have ...
DOI:: 10.1016/j.vetimm.2016.12.009
: https://doi.org/10.1016/j.vetimm.2016.12.009

71. Effect of cryopreservation on viability and growth efficiency of stromal-epithelial cells derived from neonatal human thymus

Author:: Valentin P. Shichkin; Oleksandr I. Gorbach; Olga A. Zuieva; Nataliia I. Grabchenko; Irina A. Aksyonova; Boris M. Todurov
Source:: Cryobiology 2017 v.78 pp. 70-79
ISSN:: 0011-2240
Subject:: T-lymphocytes; adaptive immunity; autografting; cell suspension culture; cryopreservation; cryoprotectants; epithelial cells; freeze-thaw cycles; glycerol; heart diseases; humans; neonates; patients; starch; storage; sucrose; thymus gland; viability
Abstract:: ... The thymus is the major site of T lymphocyte generation and so is critical for a functional adaptive immune system. Since, thymectomy is a component of neonatal surgery for congenital heart diseases, it provides great potential for collection and storage of thymic tissue for autologous transplantation. However, specific investigation into the optimum parameters for thymic tissue cryopreservation h ...
DOI:: 10.1016/j.cryobiol.2017.06.010
: https://doi.org/10.1016/j.cryobiol.2017.06.010

72. Effect of porcine circovirus type 2 (PCV2) on the function of splenic CD11c+ dendritic cells in mice

Author:: Xiaobo Wang; Ligong Chen; Wanzhe Yuan; Yanqin Li; Limin Li; Tanqing Li; Huanrong Li; Qinye Song
Source:: Archives of virology 2017 v.162 no.5 pp. 1289-1298
ISSN:: 0304-8608
Subject:: CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Porcine circovirus-2; adaptive immunity; chemical elements; chronic diseases; dendritic cells; endocytosis; enzyme-linked immunosorbent assay; flow cytometry; immune response; immunomodulators; interferon-alpha; interferon-gamma; interleukin-12; interleukin-4; mice; secretion; spleen; swine; tumor necrosis factor-alpha; viruses
Abstract:: ... Porcine circovirus-associated disease (PCVAD) caused by porcine circovirus type 2 (PCV2) is an important disease in the global pig industry. Dendritic cells (DCs) are the primary immune cells capable of initiating adaptive immune responses as well as major target cells of PCV2. To determine whether PCV2 affects the immune functions of DCs, we evaluated the expression of endocytosis and co-stimulat ...
DOI:: 10.1007/s00705-017-3221-8
: https://doi.org/10.1007/s00705-017-3221-8

73. Effect of recombinant bovine somatotropin on leukocyte mRNA expression for genes related to cell energy metabolism, cytokine production, phagocytosis, oxidative burst, and adaptive immunity

Author:: P.R.B. Silva; C.D. Nelson; J.P. Driver; W.W. Thatcher; R.C. Chebel
Source:: Journal of dairy science 2017 v.100 no.10 pp. 8471-8483
ISSN:: 0022-0302
Subject:: absorbance; adaptive immunity; blood serum; calving; dairy cows; energy metabolism; fluorescence; gene expression; genes; geometry; granulocytes; haptoglobins; immune response; immunoglobulin G; insulin-like growth factor I; intracellular signaling peptides and proteins; messenger RNA; ovalbumin; phagocytosis; pregnancy; somatotropin; tumor necrosis factor-alpha
Abstract:: ... Objectives of the current experiment were to evaluate the effects of treatment of periparturient dairy cows with recombinant bovine somatotropin (rbST) on mRNA expression in peripheral leukocytes for genes related to the somatotropic axis, cell energy metabolism, and innate and adaptive immune responses. Cows were enrolled in the experiment at 253 ± 3 d of gestation and assigned to an untreated co ...
DOI:: 10.3168/jds.2016-12106
: https://doi.org/10.3168/jds.2016-12106

74. Effectiveness of Germination on Protein Hydrolysis as a Way To Reduce Adverse Reactions to Wheat

Author:: Boukid Fatma; Prandi Barbara; Buhler Sofie; Sforza Stefano
Source:: Journal of agricultural and food chemistry 2017 v.65 no.45 pp. 9854-9860
ISSN:: 1520-5118
Subject:: adaptive immunity; adverse effects; asthma; celiac disease; foods; genotype; germination; gluten; hydrolysis; in vitro digestion; inflammation; ingredients; innate immunity; lipids; peptides; polyacrylamide gel electrophoresis; protein composition; protein degradation; starch; statistical analysis; wheat; wheat protein
Abstract:: ... In this work, the aim is to study the effectiveness of germination on wheat protein degradation, with a specific focus on proteins involved in adverse reactions to wheat. The effects of 8 days of germination at 25 °C on the chemical composition and the protein profile were determined. Germination did not have a significant effect on starch, protein, lipid, and ash contents. General protein profile ...
DOI:: 10.1021/acs.jafc.7b03175
: https://doi.org/10.1021/acs.jafc.7b03175

75. Effectiveness of formalin-killed vaccines containing CpG oligodeoxynucleotide 1668 adjuvants against Vibrio harveyi in orange-spotted grouper

Author:: Hai Trong Nguyen; Thuy Thi Thu Nguyen; Yi-Ting Wang; Pei-Chyi Wang; Shih-Chu Chen
Source:: Fish & shellfish immunology 2017 v.68 pp. 124-131
ISSN:: 1050-4648
Subject:: Epinephelus coioides; Toll-like receptor 9; Vibrio harveyi; adaptive immunity; adjuvants; antibodies; grouper; immune response; immunization; major histocompatibility complex; messenger RNA; oligodeoxyribonucleotides; pathogens; plasmids; spleen; tumor necrosis factor-alpha; vaccines; vibriosis
Abstract:: ... Vibrio harveyi is a major bacterial pathogen that causes serious vibriosis in cultured groupers, leading to massive deaths. In this study, we evaluated the immune responses and protective efficacy of vaccines containing V. harveyi formalin-killed cells (FKC) formulated with CpG ODN 1668-enriched plasmids (p30CpG and p60CpG) in the orange-spotted grouper. Results indicated that antibody titres were ...
DOI:: 10.1016/j.fsi.2017.07.018
: https://doi.org/10.1016/j.fsi.2017.07.018

76. Effects of PM2.5 exposure on the Notch signaling pathway and immune imbalance in chronic obstructive pulmonary disease

Author:: Xing-yu Gu; Xu Chu; Xiao-Li Zeng; Hai-Rong Bao; Xiao-Ju Liu
Source:: Environmental pollution 2017 pp. -
ISSN:: 0269-7491
Subject:: T-lymphocytes; Western blotting; adaptive immunity; aerosols; animal models; blood serum; breathing; cigarettes; density gradient centrifugation; enzyme-linked immunosorbent assay; flow cytometry; interferon-gamma; interleukin-10; interleukin-17; interleukin-4; intraperitoneal injection; messenger RNA; mice; particulates; proteins; respiratory tract diseases; reverse transcriptase polymerase chain reaction; signal transduction
Abstract:: ... Chronic Obstructive Pulmonary Disease (COPD) is associated with T lymphocytes subset (Th1/Th2, Th17/Treg) imbalance. Notch signaling pathway plays a key role in the development of the adaptive immunity. The immune disorder induced by fine particulate matter (PM2.5) is related to COPD. The aim of this study was to investigate the mechanism by which PM2.5 influences the Notch signaling pathway leadi ...
DOI:: 10.1016/j.envpol.2017.03.070
: https://doi.org/10.1016/j.envpol.2017.03.070

77. Efficacy of PLGA microparticle-encapsulated formalin-killed Aeromonas hydrophila cells as a single-shot vaccine against A. hydrophila infection

Author:: Saekil Yun; Jin Woo Jun; Sib Sankar Giri; Hyoun Joong Kim; Cheng Chi; Sang Geun Kim; Sang Wha Kim; Se Chang Park
Source:: Vaccine 2017 v.35 no.32 pp. 3959-3965
ISSN:: 0264-410X
Subject:: Aeromonas hydrophila; Cobitidae; Cyprinus carpio; adaptive immunity; agglutination; antibodies; antigens; aquaculture; blood; carp; disease prevention; gene expression; gene expression regulation; genes; immunoglobulin M; interleukin-10; interleukin-1beta; kidneys; lysozyme; messenger RNA; scanning electron microscopy; survival rate; transforming growth factor beta; tumor necrosis factor-alpha; vaccination; vaccines
Abstract:: ... Control and prevention of disease is a high priority in aquaculture, and vaccination is important to prevent outbreaks. Here, poly(d,l-lactide-co-glycolic acid) (PLGA) microparticles (MPs) approximately 36μm in diameter were used to encapsulate and deliver Aeromonas hydrophila formalin-killed cells (FKC) as an antigen, and the innate and adaptive immune responses of cyprinid loaches and common car ...
DOI:: 10.1016/j.vaccine.2017.06.005
: https://doi.org/10.1016/j.vaccine.2017.06.005

78. Efficacy of Spirulina platensis diet supplements on disease resistance and immune-related gene expression in Cyprinus carpio L. exposed to herbicide atrazine

Author:: Samah R. Khalil; Rasha M. Reda; Ashraf Awad
Source:: Fish & shellfish immunology 2017 v.67 pp. 119-128
ISSN:: 1050-4648
Subject:: atrazine; immunoglobulin M; Cyprinus carpio; Arthrospira platensis; genes; dietary supplements; aquaculture; adaptive immunity; carp; gene expression; spleen; disease resistance; interleukin-10; gene expression regulation; messenger RNA; feed additives; transcription (genetics); subchronic exposure; Aeromonas sobria; immune response; kidneys; antibacterial properties; lysozyme; quantitative polymerase chain reaction; viability; survival rate; complement; inflammation
Abstract:: ... The present study evaluated the immunotoxicological effects of the herbicide atrazine (ATZ) at sub-lethal concentrations and the potential ameliorative influence of Spirulina platensis (SP) over a sub-chronic exposure period on Cyprinus carpio L., also known as common carp. Common carp was sampled after a 40-days exposure to ATZ (428 μg/L) and SP (1%), individually or in combination to assess the ...
DOI:: 10.1016/j.fsi.2017.05.065
: https://doi.org/10.1016/j.fsi.2017.05.065

79. Enhanced ambient UVB light affects growth, body condition and the investment in innate and adaptive immunity in three-spined sticklebacks (Gasterosteus aculeatus)

Author:: Simon Vitt; Anna K. Rahn; Lisa Drolshagen; Theo C. M. Bakker; Jörn P. Scharsack; Ingolf P. Rick
Source:: Aquatic ecology 2017 v.51 no.4 pp. 499-509
ISSN:: 1386-2588
Subject:: Gasterosteus aculeatus; adaptive immunity; aquatic ecosystems; body condition; chronic exposure; fish; immune response; solar radiation; ultraviolet radiation
Abstract:: ... With ongoing environmental change, ultraviolet-B radiation (UVB) reaching the Earth’s surface has increased over recent decades with consequences for terrestrial and also aquatic ecosystems. Despite evidence for direct physiological and immunological responses of aquatic animals following enhanced UVB exposure, studies investigating indirect impacts of ambient UVB radiation are scarce and mainly u ...
DOI:: 10.1007/s10452-017-9632-5
: https://doi.org/10.1007/s10452-017-9632-5

80. Enterovirus 71-induced has-miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1

Author:: Na Feng; Zhizhao Zhou; Yuanxia Li; Lifang Zhao; Zhengfeng Xue; Rong Lu; Kunpeng Jia
Source:: Virus research 2017 v.237 pp. 27-36
ISSN:: 0168-1702
Subject:: Enterovirus; adaptive immunity; etiological agents; hand, foot and mouth disease; immune system; interferons; interleukin-1; monitoring; public health; viruses
Abstract:: ... Enterovirus71(EV71), the etiological agent of hand-foot-and-mouth disease, has increasingly become a public health challenge around the world. Type I interferons (IFNs) are an important family of cytokines that regulate innate and adaptive immune responses to pathogens.These pathways are tightly regulated by the host to prevent an inappropriate cellular response, but viruses can modulate these pat ...
DOI:: 10.1016/j.virusres.2017.05.008
: https://doi.org/10.1016/j.virusres.2017.05.008

81. Evaluation of the immunocrit method to detect failure of passively acquired immunity in dairy calves

Author:: Kimberly A. Thompson; Marie C. Rayburn; Munashe Chigerwe
Source:: Journal of the American Veterinary Medical Association 2017 v.251 no.6 pp. 702-705
ISSN:: 0003-1488
Subject:: adaptive immunity; ammonium sulfate; blood sampling; blood serum; confidence interval; dairy calves; females; graphs; immunoglobulin G; reference standards
Abstract:: ... OBJECTIVE To evaluate the usefulness of serum immunocrit measurement to detect failure of passively acquired immunity (FPI) in dairy calves. DESIGN Diagnostic test evaluation. ANIMALS 249 female dairy calves (age, 2 to 6 days). PROCEDURES A blood sample was collected from each calf, and serum was harvested. Immunocrit was measured in serum samples by use of 55% ammonium sulfate solution and the st ...
DOI:: 10.2460/javma.251.6.702
: https://doi.org/10.2460/javma.251.6.702

82. Evasion of host immune defenses by human papillomavirus

Author:: Joseph A. Westrich; Cody J. Warren; Dohun Pyeon
Source:: Virus research 2017 v.231 pp. 21-33
ISSN:: 0168-1702
Subject:: Papillomaviridae; adaptive immunity; disease course; gene expression; genome; humans; immune response; immunomodulators; keratinocytes; medical treatment; neoplasms; oncogene proteins; post-translational modification; protein-protein interactions; sequence diversity; viruses
Abstract:: ... A majority of human papillomavirus (HPV) infections are asymptomatic and self-resolving in the absence of medical interventions. Various innate and adaptive immune responses, as well as physical barriers, have been implicated in controlling early HPV infections. However, if HPV overcomes these host immune defenses and establishes persistence in basal keratinocytes, it becomes very difficult for th ...
DOI:: 10.1016/j.virusres.2016.11.023
PubMed:: 27890631
PubMed Central:: PMC5325784
: https://doi.org/10.1016/j.virusres.2016.11.023

83. Evidence for the effects of yogurt on gut health and obesity

Author:: Ruisong Pei; Derek A. Martin; Diana M. DiMarco; Bradley W. Bolling
Source:: Critical reviews in food science and nutrition 2017 v.57 no.8 pp. 1569-1583
ISSN:: 1549-7852
Subject:: absorption barrier; adaptive immunity; adipose tissue; appetite; chronic diseases; constipation; cytokines; developing countries; diabetes; diarrhea; diet; endotoxins; exercise; gastrointestinal system; hypertension; inflammation; lactose intolerance; lipid composition; microorganisms; neoplasms; obesity; pathogens; risk; yogurt
Abstract:: ... Obesity is associated with increased risk for chronic diseases, and affects both developed and developing nations. Yogurt is a nutrient-dense food that may benefit individuals with lactose intolerance, constipation and diarrheal diseases, hypertension, cardiovascular diseases, diabetes, and certain types of cancer. Emerging evidence suggests that yogurt consumption might also improve the health of ...
DOI:: 10.1080/10408398.2014.883356
: https://doi.org/10.1080/10408398.2014.883356

84. Evolution of antigenic diversity in the tick‐transmitted bacterium Borrelia afzelii: a role for host specialization?

Author:: L. Råberg; Å. Hagström; M. Andersson; S. Bartkova; K. Scherman; M. Strandh; B. Tschirren
Source:: Journal of evolutionary biology 2017 v.30 no.5 pp. 1034-1041
ISSN:: 1010-061X
Subject:: Borrelia afzelii; adaptive immunity; antigenic variation; bacteria; coevolution; correlation; hosts; quantitative polymerase chain reaction; rodents; shrews; surface proteins; ticks
Abstract:: ... Antigenic diversity in pathogenic microbes can be a result of at least three different processes: diversifying selection by acquired immunity, host–pathogen coevolution and/or host specialization. Here, we investigate whether host specialization drives diversity at ospC (which encodes an immunodominant surface protein) in the tick‐transmitted bacterium Borrelia afzelii. We determined prevalence an ...
DOI:: 10.1111/jeb.13075
: https://doi.org/10.1111/jeb.13075

85. Evolution of lymphocytes. Immunoglobulin T of the teleost sea bass (Dicentrarchus labrax): Quantitation of gene expressing and immunoreactive cells

Author:: S. Picchietti; N. Nuñez-Ortiz; V. Stocchi; E. Randelli; F. Buonocore; L. Guerra; G. Scapigliati
Source:: Fish & shellfish immunology 2017 v.63 pp. 40-52
ISSN:: 1050-4648
Subject:: Dicentrarchus labrax; Oncorhynchus mykiss; Western blotting; adaptive immunity; antigens; antiserum; bass; blood serum; complementary DNA; enzyme-linked immunosorbent assay; evolution; flow cytometry; fluorescent antibody technique; genes; gills; immunization; immunoglobulin M; immunoglobulin T; immunohistochemistry; in situ hybridization; intestines; kidneys; lymphocytes; messenger RNA; mucus; nucleotide sequences; oligonucleotides; polyclonal antibodies; polypeptides; rabbits; reverse transcriptase polymerase chain reaction; spleen; synthetic peptides; tissues
Abstract:: ... Immunoglobulin T (IgT) is one of the key effector molecules of jawed vertebrate's adaptive immune system, and in this work we describe the quantitative distribution of IgT-expressing and IgT-producing cells in tissues of the European seabass Dicentrarchus labrax by using mRNA riboprobes and a specific anti-IgT antibody.A polyclonal antiserum (pAb) was prepared by immunizing rabbits with three synt ...
DOI:: 10.1016/j.fsi.2017.02.002
: https://doi.org/10.1016/j.fsi.2017.02.002

86. Expanding biological activities of Ts19 Frag-II toxin: Insights into IL-17 production

Author:: Felipe Augusto Cerni; Manuela Berto Pucca; Karina Furlani Zoccal; Fabiani Gai Frantz; Lucia Helena Faccioli; Eliane Candiani Arantes
Source:: Toxicon 2017 v.134 pp. 18-25
ISSN:: 0041-0101
Subject:: Tityus serrulatus; adaptive immunity; alanine transaminase; beta-globulins; bioactive properties; blood serum; gamma-globulins; inflammation; innate immunity; interleukin-17; interleukin-6; mice; monocytes; neutrophils; nitric oxide; toxins; tumor necrosis factor-alpha; urea; venoms
Abstract:: ... Tityus serrulatus (Ts) venom is composed of a mixture of toxins presenting diverse biological functions. However, although this venom has been studied over the past three decades, omics analysis revealed that most of its toxins are not identified or their biological activities are unknown. Ts19 Frag-II is included in this group, which function is still uncertain. This study aimed to expand the bio ...
DOI:: 10.1016/j.toxicon.2017.05.013
: https://doi.org/10.1016/j.toxicon.2017.05.013

87. Expansion of CD11b+Ly-6C+ myeloid-derived suppressor cells (MDSCs) driven by galectin-9 attenuates CVB3-induced myocarditis

Author:: Yingying Zhang; Mengying Zhang; Xueqin Li; Zongsheng Tang; Ling He; Kun Lv
Source:: Molecular Immunology 2017 pp. -
ISSN:: 0161-5890
Subject:: CD4-positive T-lymphocytes; adaptive immunity; arginine; cell proliferation; heart; inducible nitric oxide synthase; interferon-gamma; interleukin-4; mice; myocarditis; suppressor cells
Abstract:: ... Galectin-9 is known to play a role in the modulation of innate and adaptive immunity to ameliorate CVB3-induced myocarditis. In the present study, we found that galectin-9 induced the expansion of CD11b+Ly-6C+ myeloid-derived suppressor cells (MDSCs) in the heart from CVB3-infected mice. Adoptive transfer of CD11b+Ly-6C+ MDSCs significantly alleviated myocarditis accompanied by increased Th2 and T ...
DOI:: 10.1016/j.molimm.2017.01.013
: https://doi.org/10.1016/j.molimm.2017.01.013

88. Experimental Hendra virus infection of dogs: virus replication, shedding and potential for transmission

Author:: DJ Middleton; S Riddell; R Klein; R Arkinstall; J Haining; L Frazer; C Mottley; R Evans; D Johnson; J Pallister
Source:: Australian veterinary journal 2017 v.95 no.1-2 pp. 10-18
ISSN:: 0005-0423
Subject:: nose; urine; tonsils; ferrets; genes; blood; virus replication; risk; infectious diseases; adaptive immunity; mouth; spleen; viruses; people; lymph nodes; central nervous system; acute course; dogs; pathogenicity; neutralizing antibodies; kidneys; Hendra henipavirus; neutralization; dog diseases; Beagle; horses; Australia
Abstract:: ... OBJECTIVE: Characterisation of experimental Hendra virus (HeV) infection in dogs and assessment of associated transmission risk. METHODS: Beagle dogs were exposed oronasally to Hendra virus/Australia/Horse/2008/Redlands or to blood collected from HeV‐infected ferrets. Ferrets were exposed to oral fluids collected from dogs after canine exposure to HeV. Observations made and samples tested post‐exp ...
DOI:: 10.1111/avj.12552
: https://doi.org/10.1111/avj.12552

89. Exploiting virus-like particles as innovative vaccines against emerging viral infections

Author:: Hotcherl Jeong; Baik Lin Seong
Source:: journal of microbiology 2017 v.55 no.3 pp. 220-230
ISSN:: 1225-8873
Subject:: adaptive immunity; antigen-presenting cells; bioprocessing; cell culture; cost effectiveness; humans; livestock; public health; vaccination; vaccines; viral proteins; virus-like particles; viruses
Abstract:: ... Emerging viruses pose a major threat to humans and livestock with global public health and economic burdens. Vaccination remains an effective tool to reduce this threat, and yet, the conventional cell culture often fails to produce sufficient vaccine dose. As an alternative to cell-culture based vaccine, virus-like particles (VLPs) are considered as a highpriority vaccine strategy against emerging ...
DOI:: 10.1007/s12275-017-7058-3
PubMed:: 28243941
PubMed Central:: PMC7090582
: https://doi.org/10.1007/s12275-017-7058-3

90. Exploring the potential of genome editing CRISPR-Cas9 technology

Author:: Vijai Singh; Darren Braddick; Pawan Kumar Dhar
Source:: Gene 2017 v.599 pp. 1-18
ISSN:: 0378-1119
Subject:: Archaea; DNA repair; adaptive immunity; bacteria; genome; image analysis; loci; plasmids; viruses
Abstract:: ... CRISPR-Cas9 is an RNA-mediated adaptive immune system that protects bacteria and archaea from viruses or plasmids. Herein we discuss the recent development of CRISPR-Cas9 into a key technology for genome editing, targeting, and regulation in a wide range of organisms and cell types. It requires a custom designed single guide-RNA (sgRNA), a Cas9 endonuclease, and PAM sequences in the target region. ...
DOI:: 10.1016/j.gene.2016.11.008
: https://doi.org/10.1016/j.gene.2016.11.008

91. Expression of immune genes in systemic and mucosal immune tissues of channel catfish vaccinated with live theronts of Ichthyophthirius multifiliis

Author:: De-Hai Xu; Gabriel S.A. Moreira; Craig A. Shoemaker; Dunhua Zhang; Benjamin H. Beck
Source:: Fish & shellfish immunology 2017 v.66 no. pp. 540-547
ISSN:: 1050-4648
Subject:: Ichthyophthirius multifiliis; Ictalurus punctatus; Toll-like receptors; adaptive immunity; antibodies; cytokines; freshwater fish; gene expression; gene expression regulation; genes; gills; immune response; immunoglobulin M; interferon-gamma; intestines; liver; spleen; vaccination
Abstract:: ... Ichthyophthiriasis caused by Ichthyophthirius multifiliis (Ich) has a worldwide distribution and affects most freshwater fishes. Fish surviving natural infection and/or immunized with Ich develop strong innate and adaptive immune responses. However, there is a lack of the knowledge regarding immune gene expression patterns in systemic and mucosal immune tissues, and how immune genes interact and l ...
DOI:: 10.1016/j.fsi.2017.05.051
CHORUS:: 10.1016/j.fsi.2017.05.051
Chorus Open Access:: 10.1016/j.fsi.2017.05.051
: https://doi.org/10.1016/j.fsi.2017.05.051

92. Expression of immunoproteasome subunits in the porcine lung: Alterations during normal and inflammatory conditions

Author:: Qiang Liu; Yong-Li Zhang; Shou-Ping Hu; Ze-Lin Ma; Su-Li Gao; Bin Sun; Fei Xiao; Zhuo Zhang; Xue-Hui Cai; Xi-Jun He
Source:: Veterinary microbiology 2017 v.210 pp. 134-141
ISSN:: 0378-1135
Subject:: Porcine reproductive and respiratory syndrome virus; adaptive immunity; antigens; cytoplasm; cytotoxic T-lymphocytes; epithelial cells; interferon-gamma; lungs; macrophages; major histocompatibility complex; pathogens; proteasome endopeptidase complex; proteolysis; receptors; swine; therapeutics
Abstract:: ... The elimination of infected cells by cytotoxic T lymphocytes (CTLs) occurs through interactions between T cell receptors (TCRs) and pathogen-derived antigenic peptide-major histocompatibility complex (MHC) class I complexes. The immunoproteasome (i-proteasome), which is a large proteolytic machine derived from the constitutive proteasome, is highly efficient at processing antigens for presentation ...
DOI:: 10.1016/j.vetmic.2017.07.024
: https://doi.org/10.1016/j.vetmic.2017.07.024

93. Expression pattern of CD11c on lung immune cells after disseminated murine cytomegalovirus infection

Author:: Yi Liao; Xinglou Liu; Yuan Huang; Heyu Huang; Yuanyuan Lu; Yanan Zhang; Sainan Shu; Feng Fang
Source:: Virology journal 2017 v.14 no.1 pp. 132
ISSN:: 1743-422X
Subject:: CD8-positive T-lymphocytes; Cytomegalovirus; Muromegalovirus; adaptive immunity; animal models; cell suspension culture; flow cytometry; immune evasion; lipopolysaccharides; lungs; mice; natural killer cells; spleen
Abstract:: ... BACKGROUND: Cytomegalovirus (CMV) infection occurs frequently and is widespread globally. Numerous studies have shown that various types of immune cells play roles in mediating the response to CMV infection. CD11c, a commonly used dendritic cell (DC) marker, is expressed by other immune cells as well, such as T cells. This study analyzed the immune cells that express CD11c and monitored the expres ...
DOI:: 10.1186/s12985-017-0801-x
PubMed:: 28720115
PubMed Central:: PMC5516330
: https://doi.org/10.1186/s12985-017-0801-x

94. Feature selection using a one dimensional naïve Bayes’ classifier increases the accuracy of support vector machine classification of CDR3 repertoires

Author:: Mattia Cinelli; , Yuxin Sun; Katharine Best; James M. Heather; Shlomit Reich-Zeliger; Eric Shifrut; Nir Friedman; John Shawe-Taylor; Benny Chain
Source:: Bioinformatics 2017 v.33 no.7 pp. 951-955
ISSN:: 1460-2059
Subject:: Bayesian theory; CD4-positive T-lymphocytes; DNA; adaptive immunity; adjuvants; amino acids; antigens; bioinformatics; computer software; high-throughput nucleotide sequencing; immunization; ovalbumin; support vector machines; vertebrates
Abstract:: ... Motivation: Somatic DNA recombination, the hallmark of vertebrate adaptive immunity, has the potential to generate a vast diversity of antigen receptor sequences. How this diversity captures antigen specificity remains incompletely understood. In this study we use high throughput sequencing to compare the global changes in T cell receptor β chain complementarity determining region 3 (CDR3β) sequen ...
DOI:: 10.1093/bioinformatics/btw771
PubMed:: 28073756
PubMed Central:: PMC5860388
: https://doi.org/10.1093/bioinformatics/btw771

95. FmLC5, a putative galactose-binding C-type lectin with two QPD motifs from the hemocytes of Fenneropenaeus merguiensis participates in shrimp immune defense

Author:: Wilaiwan Senghoi; Phanthipha Runsaeng; Prapaporn Utarabhand
Source:: Journal of invertebrate pathology 2017 v.150 pp. 136-144
ISSN:: 0022-2011
Subject:: Fenneropenaeus merguiensis; Vibrio harveyi; White spot syndrome virus; adaptive immunity; amino acids; bacteria; calcium; complementary DNA; genes; hemocytes; immune response; in situ hybridization; innate immunity; isoelectric point; lectins; lipopolysaccharides; molecular weight; mortality; open reading frames; receptors; reverse transcriptase polymerase chain reaction; shrimp; signal peptide; viruses
Abstract:: ... Crustaceans are deficient in adaptive immune system. They depend completely on an innate immunity to protect themselves from invading microorganisms. One kind of pattern recognition receptors that contribute roles in the innate immunity is lectin. A new C-type lectin gene designated as FmLC5 was isolated from Fenneropenaeus merguiensis. Its full-length cDNA is composed of 1526bp and one open readi ...
DOI:: 10.1016/j.jip.2017.09.013
: https://doi.org/10.1016/j.jip.2017.09.013

96. Gene expression and in silico analysis of snakehead murrel interleukin 8 and antimicrobial activity of C-terminal derived peptide WS12

Author:: Akila Sathyamoorthi; Prasanth Bhatt; Gayathri Ravichandran; Venkatesh Kumaresan; Mariadhas Valan Arasu; Naif Abdullah Al-Dhabi; Jesu Arockiaraj
Source:: Veterinary immunology and immunopathology 2017 v.190 pp. 1-9
ISSN:: 0165-2427
Subject:: Bacillus cereus; Channa striata; adaptive immunity; amino acids; anti-infective agents; antimicrobial properties; bacteria; bioinformatics; cDNA libraries; chemoattractants; complementary DNA; cytotoxicity; fish; gene expression; humans; interleukin-8; leukocytes; liver; messenger RNA; pathogens; scanning electron microscopy
Abstract:: ... Chemokines have been known for their wide range of functions including chemoattractant property in humans and other vertebrate organisms. They act as a bridge between innate and adaptive immune system. In the present study, we have identified a CXC chemokine from the cDNA library of C. striatus; on the basis of orthology study, it was found highly identical to interleukin 8 (IL8). The bioinformati ...
DOI:: 10.1016/j.vetimm.2017.06.008
: https://doi.org/10.1016/j.vetimm.2017.06.008

97. Gene expression and tissue distribution of β-defensins in Chinese Min pigs and Landrace pigs

Author:: W. Jiao; Q. Ma; X. Lv; A. Shan; Z. Li
Source:: Czech Journal of Animal Science v.62 no.4 pp. 178-183
ISSN:: 1212-1819
Subject:: adaptive immunity; animal science; antimicrobial peptides; chemotaxis; disease resistance; gene expression; genes; heart; kidneys; landraces; quantitative polymerase chain reaction; swine; tissue distribution; tongue
Abstract:: ... β-Defensins are a major group of mammalian antimicrobial peptides and play an important role in innate and adaptive immunity due to their antimicrobial, chemotactic, and regulatory activities. In this study, the tissue distribution of porcine β-defensin (pBD-1, pBD-2, and pBD-3) gene expression was determined using real-time polymerase chain reaction in 14-day-old Chinese Min pigs and Landrace pig ...
DOI:: 10.17221/84/2015-cjas
: https://doi.org/10.17221/84/2015-cjas

98. Gene expression profiling of U2AF2 dependent RNA-protein interactions during CD4+ T cell activation

Author:: Thomas C Whisenant
Source:: Genomics data 2017 v.11 pp. 77-80
ISSN:: 2213-5960
Subject:: CD4-positive T-lymphocytes; RNA-binding proteins; adaptive immunity; alternative splicing; gene expression; genes; mammals; microarray technology; sequence analysis; small interfering RNA
Abstract:: ... CD4 T cell activation is a central component of the mammalian adaptive immune response and is underscored by a dramatic change in the gene expression profile in these cells. The changes in gene expression that occur during T cell activation are regulated in multiple ways including post-transcriptionally by complexes of RNA-binding proteins. Recently, our study explored the role of the RNA-binding ...
DOI:: 10.1016/j.gdata.2016.12.006
PubMed:: 28050347
PubMed Central:: PMC5192059
: https://doi.org/10.1016/j.gdata.2016.12.006

99. Helminth-induced apoptosis: a silent strategy for immunosuppression

Author:: AMIN ZAKERI
Source:: Parasitology 2017 v.144 no.13 pp. 1663-1676
ISSN:: 1469-8161
Subject:: adaptive immunity; antineoplastic activity; apoptosis; bacteria; helminths; immune response; immunosuppression; inflammation; neoplasms; receptors; viruses
Abstract:: ... During microbial infections, both innate and adaptive immunity are activated. Viruses and bacteria usually induce an acute inflammation in the first setting of infection, which helps the eliciting an effective immune response. In contrast, macroparasites such as helminths are a highly successful group of invaders known to be capable of maintaining a chronic infestation with the minimum instigation ...
DOI:: 10.1017/S0031182017000841
PubMed:: 28659212
: https://doi.org/10.1017/S0031182017000841

100. High-throughput sequencing of the T-cell receptor repertoire: pitfalls and opportunities

Author:: James M Heather; Mazlina Ismail; Theres Oakes; Benny Chain
Source:: Briefings in bioinformatics 2017 v.19 no.4 pp. 554-565
ISSN:: 1477-4054
Subject:: DNA; T-lymphocytes; adaptive immunity; algorithms; antigens; artificial intelligence; bioinformatics; biomarkers; cross reaction; genes; high-throughput nucleotide sequencing; nucleotide sequences; receptors
Abstract:: ... T-cell specificity is determined by the T-cell receptor, a heterodimeric protein coded for by an extremely diverse set of genes produced by imprecise somatic gene recombination. Massively parallel high-throughput sequencing allows millions of different T-cell receptor genes to be characterized from a single sample of blood or tissue. However, the extraordinary heterogeneity of the immune repertoir ...
DOI:: 10.1093/bib/bbw138
PubMed:: 28077404
PubMed Central:: PMC6054146
: https://doi.org/10.1093/bib/bbw138

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1. Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14 Attenuate Gardnerella vaginalis-Infected Bacterial Vaginosis in Mice

2. Administration of a polyphenol-enriched feed to farmed sea bass (Dicentrarchus labrax L.): Kidney melanomacrophages response

3. Alteration of the number and percentage of innate immune cells in preschool children from an e-waste recycling area

4. Altered distribution of peripheral blood dendritic cell subsets in patients with pulmonary paracoccidioidomycosis

5. Antibodies: From novel repertoires to defining and refining the structure of biologically important targets

6. Antigenic GM3 Lactone Mimetic Molecule Integrated Mannosylated Glycopeptide Nanofibers for the Activation and Maturation of Dendritic Cells

7. Application of the CRISPR gene‐editing technique in insect functional genome studies – a review

8. The Arp2/3 complex binding protein HS1 is required for efficient dendritic cell random migration and force generation

9. Assessing in vivo digestibility and effects on immune system of sheep fed alfalfa hay supplemented with a fixed amount of Ulva rigida and Gracilaria vermiculophylla

10. Autophagy induced by infectious hematopoietic necrosis virus inhibits intracellular viral replication and extracellular viral yields in epithelioma papulosum cyprini cell line

11. Axl signaling induces development of natural killer cells in vitro and in vivo

12. BCG immune activation reduces growth and angiogenesis in an in vitro model of head and neck squamous cell carcinoma

13. Bacterial Virulence Factors: Secreted for Survival

14. Bacterial ghosts as adjuvants: mechanisms and potential

15. Bead-based flow-cytometry for semi-quantitative analysis of complex membrane vesicle populations released by bacteria and host cells

16. Bioengineering towards self-assembly of particulate vaccines

17. Biomaterials innovation for next generation ex vivo immune tissue engineering

18. Bovine single chain Fv antibody inhibits bovine herpesvirus-1 infectivity by targeting viral glycoprotein D

19. CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis

20. CD44 enhances macrophage phagocytosis and plays a protective role in Streptococcus equi subsp. zooepidemicus infection

21. CRISPR/Cas9 in insects: Applications, best practices and biosafety concerns

22. Characteristics of NK cells from leukemic microenvironment in MLL-AF9 induced acute myeloid leukemia

23. Characterization and complete genome sequences of L. rhamnosus DSM 14870 and L. gasseri DSM 14869 contained in the EcoVag® probiotic vaginal capsules

24. Characterization of a specific monoclonal antibody against immunoglobulin light kappa/L1 chain in olive flounder (Paralichthys olivaceus)

25. Characterization of immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution

26. Characterization of major histocompatibility complex class I, and class II DRB loci of captive and wild Indian leopards (Panthera pardus fusca)

27. Characterization of peritoneal leukemia-associated macrophages in Notch1-induced mouse T cell acute lymphoblastic leukemia

28. Characterization, expression, and evolutionary analysis of new TLR3 and TLR5M genes cloned from the spiny eel Mastacembelus armatus

29. Characterize a typically Dscam with alternative splicing in mud crab Scylla paramamosain

30. Chromatographic and mass spectrometry analysis of wheat flour prolamins, the causative compounds of celiac disease

31. Cloning and functional characterization of IRAK4 in large yellow croaker (Larimichthys crocea) that associates with MyD88 but impairs NF-κB activation

32. Cloning, characterization, and function of MyD88 in silvery pomfret (Pampus argenteus) in response to bacterial challenge

33. Coccinia grandis (L.) Voigt Leaf Extract Exhibits Antileishmanial Effect Through Pro-inflammatory Response: An In Vitro Study

34. Comparative analysis of CRISPR‐Cas systems in Klebsiella genomes

35. Comparative and temporal transcriptome analysis of peste des petits ruminants virus infected goat peripheral blood mononuclear cells

36. Comparative genomic and phylogenetic analysis of a toxigenic clinical isolate of Corynebacterium diphtheriae strain B-D-16-78 from Malaysia

37. Compartmentalized antimicrobial defenses in response to flagellin

38. Complement factor H in host defense and immune evasion

39. Complement’s hidden arsenal: New insights and novel functions inside the cell

40. Comprehensive understanding of PM2.5 on gene and microRNA expression patterns in zebrafish (Danio rerio) model

41. Convergent evolution of the adaptive immune response in jawed vertebrates and cyclostomes: An evolutionary biology approach based study

42. Coupling immunity and programmed cell suicide in prokaryotes: Life‐or‐death choices

43. Cow's milk and rice fermented with Lactobacillus paracasei CBA L74 prevent infectious diseases in children: A randomized controlled trial

44. CpG ODN 1668 induce innate and adaptive immune responses in rock bream (Oplegnathus fasciatus) against rock bream iridovirus (RBIV) infection

45. Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1

46. Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex

47. DNA Vaccination Partially Protects Muskellunge against Viral Hemorrhagic Septicemia Virus (VHSV‐IVb)

48. Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation

49. Deciphering antigen-responding antibody repertoires by using next-generation sequencing and confirming them through antibody-gene synthesis

50. Deciphering transcriptome profile of the yellow catfish (Pelteobagrus fulvidraco) in response to Edwardsiella ictaluri

51. Decreased vaccine antibody titers following exposure to multiple metals and metalloids in e-waste-exposed preschool children

52. Delivering adjuvants and antigens in separate nanoparticles eliminates the need of physical linkage for effective vaccination

53. Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications

54. Dendritic cell harmonised immunity to poultry pathogens; a review

55. Dendritic cells during mousepox: The role of delayed apoptosis in the pathogenesis of infection

56. Describing the diversity of Ag specific receptors in vertebrates: Contribution of repertoire deep sequencing

57. Development of a monoclonal antibody against the CD3ε of olive flounder (Paralichthys olivaceus) and its application in evaluating immune response related to CD3ε

58. Development, phenotype, and function of non-conventional B cells

59. Differences in expression of genes in the MyD88 and TRIF signalling pathways and methylation of TLR4 and TRIF in Tibetan chickens and DaHeng S03 chickens infected with Salmonella enterica serovar enteritidis

60. Differences in innate and adaptive immune response traits of Pahari (Indian non-descript indigenous breed) and Jersey crossbred cattle

61. Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation

62. Diversity, classification and evolution of CRISPR-Cas systems

63. Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome?

64. Downregulation of lizard immuno-genes in the regenerating tail and myogenes in the scarring limb suggests that tail regeneration occurs in an immuno-privileged organ

65. Drosophilosophical: Re-thinking Adaptive Immunity in the Fly

66. Dynamic interaction of neutrophils and RFP-labelled Vibrio parahaemolyticus in zebrafish (Danio rerio)

67. Early Immune Responses to Marek’s Disease Vaccines

68. Early exposure to Batrachochytrium dendrobatidis causes profound immunosuppression in amphibians

69. Echinacea pupurea extracts promote murine dendritic cell maturation by activation of JNK, p38 MAPK and NF-κB pathways

70. Effect of artificial rearing of piglets on the volume densities of M cells in the tonsils of the soft palate and ileal Peyer’s patches