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adaptive immunity
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- Author:
- Se-Eun Jang; Jin-Ju Jeong; Su-Young Choi; Hyunji Kim; Myung Joo Han; Dong-Hyun Kim
- Source:
- Nutrients 2017 v.9 no.6 pp. -
- ISSN:
- 2072-6643
- Subject:
- Gardnerella vaginalis; Lactobacillus acidophilus; Lactobacillus rhamnosus; adaptive immunity; enzyme activity; enzyme-linked immunosorbent assay; epithelial cells; flow cytometry; human cell lines; humans; immunoblotting; immunosuppression; ingredients; interleukin-10; interleukin-17; interleukin-1beta; intravaginal devices; lactoferrin; macrophages; mice; myeloperoxidase; neoplasm cells; oral administration; probiotics; quantitative polymerase chain reaction; splenocytes; transcription factor NF-kappa B; tumor necrosis factor-alpha; uterine cervical neoplasms; vagina; women
- Abstract:
- ... Oral administration of a probiotic mixture (PM; Respecta®) consisting of Lactobacillus rhamnosus HN001 (L1), Lactobacillus acidophilus La-14 (L2), and lactoferrin RCXTM results in colonization of these probiotics in the vagina of healthy women. Therefore, we examined whether vaginal colonization of the PM ingredients L1 and L2 could attenuate bacterial vaginosis (BV). BV was induced in mice via β- ...
- DOI:
- 10.3390/nu9060531
- PubMed:
- 28545241
- PubMed Central:
- PMC5490510
- https://doi.org/10.3390/nu9060531
- Author:
- Christine M. Tin; Lijuan Yuan; Rachel J. Dexter; Gabriel I. Parra; Tammy Bui; Kim Y. Green; Stanislav V. Sosnovtsev
- Source:
- Journal of virological methods 2017 pp. -
- ISSN:
- 0166-0934
- Subject:
- Norovirus; adaptive immunity; antibodies; antibody specificity; coat proteins; enzyme-linked immunosorbent assay; genotype; humans; luciferase; plasmids; precipitin tests; recombinant proteins; vaccination
- Abstract:
- ... A luciferase immunoprecipitation systems (LIPS) assay was developed to define the antigenic specificity and titer of antibodies directed against human norovirus (HuNoV). Recombinant proteins, expressed by plasmid constructs encoding Renilla luciferase (Ruc) fused to the full-length HuNoV major capsid protein (VP1) (Ruc-antigen), were generated for ten HuNoV strains. In addition, subdomain construc ...
- DOI:
- 10.1016/j.jviromet.2017.06.017
- PubMed:
- 28673856
- PubMed Central:
- PMC5592151
- https://doi.org/10.1016/j.jviromet.2017.06.017
- Author:
- Steven J. A. Kimble; April J. Johnson; Rod N. Williams; Jason T. Hoverman
- Source:
- EcoHealth 2017 v.14 no.4 pp. 810-815
- ISSN:
- 1612-9202
- Subject:
- Ranavirus; Terrapene; adaptive immunity; captive animals; clinical examination; mortality; nose; quantitative polymerase chain reaction
- Abstract:
- ... A Ranavirus outbreak in a captive population of wild-caught individuals was monitored using clinical evaluations and real-time PCR in 317 wild box turtles held in captivity during translocation. During the 2-year study period, the population experienced 71.6% mortality, suggesting that ranaviruses can rapidly attenuate populations. Wide variation in infection rate (7–94% per sampling period) was o ...
- DOI:
- 10.1007/s10393-017-1263-8
- https://doi.org/10.1007/s10393-017-1263-8
- Author:
- Lena Hammerlund Teige; Morten Lund; Hanne M. Haatveit; Magnus Vikan Røsæg; Øystein Wessel; Maria K. Dahle; Anne K. Storset
- Source:
- Fish & shellfish immunology 2017 v.63 pp. 491-499
- ISSN:
- 1050-4648
- Subject:
- Orthoreovirus; Salmo salar; adaptive immunity; antibodies; antibody formation; aquaculture; coat proteins; disease control; fish; immunoassays; immunoglobulin M; inflammation; pathogens; skeletal muscle; vaccination; vaccine development; viral nonstructural proteins; viruses
- Abstract:
- ... Future growth in aquaculture relies strongly on the control of diseases and pathogens. Vaccination has been a successful strategy for obtaining control of bacterial diseases in fish, but for viral diseases, vaccine development has been more challenging. Effective long-term protection against viral infections is not yet fully understood for fish, and in addition, optimal tools to monitor adaptive i ...
- DOI:
- 10.1016/j.fsi.2017.02.043
- https://doi.org/10.1016/j.fsi.2017.02.043
- Author:
- Phanthipha Runsaeng; Peerapong Puengyam; Prapaporn Utarabhand
- Source:
- Molecular Immunology 2017 pp. -
- ISSN:
- 0161-5890
- Subject:
- Fenneropenaeus merguiensis; Vibrio harveyi; White spot syndrome virus; acids; adaptive immunity; agglutination; antimicrobial properties; calcium; complementary DNA; double-stranded RNA; gene expression; heart; hemolymph; hepatopancreas; innate immunity; intestines; lectins; lipopolysaccharides; mannose; messenger RNA; microbial growth; molecular weight; mortality; open reading frames; pathogens; rapid amplification of cDNA ends; receptors; reverse transcriptase polymerase chain reaction; shrimp; signal peptide; stomach
- Abstract:
- ... Being one type of pattern recognition receptors (PRRs), lectins exhibit a crucial role in the defense mechanism of invertebrates which are deficient in an adaptive immune system. A new C-type lectin called FmLC3 was isolated from hepatopancreas of Fenneropenaeus merguiensis by cloning approaches, RT-PCR and 5′ and 3′ RACE (rapid amplification of cDNA ends). A full-length cDNA of FmLC3 contains 607 ...
- DOI:
- 10.1016/j.molimm.2017.10.005
- https://doi.org/10.1016/j.molimm.2017.10.005
6. A mechanistic study of Toxoplasma gondii ROP18 inhibiting differentiation of C17.2 neural stem cells
- Author:
- Xian Zhang; Rui Su; Zhengyang Cheng; Wanbo Zhu; Yelin Li; Yongzhong Wang; Jian Du; Yihong Cai; Qingli Luo; Jilong Shen; Li Yu
- Source:
- Parasites & vectors 2017 v.10 no.1 pp. 585
- ISSN:
- 1756-3305
- Subject:
- Adenoviridae; Toxoplasma gondii; adaptive immunity; beta catenin; brain; congenital abnormalities; neurons; parasites; signal transduction; stem cells; transfection; virulence
- Abstract:
- ... BACKGROUND: Congenital infection of Toxoplasma gondii is an important factor causing birth defects. The neural stem cells (NSCs) are found to be one of the target cells for the parasite during development of the brain. As a key virulence factor of the parasite that hijacks host cellular functions, ROP18 has been demonstrated to mediate the inhibition of host innate and adaptive immune responses th ...
- DOI:
- 10.1186/s13071-017-2529-2
- PubMed:
- 29169404
- PubMed Central:
- PMC5701453
- https://doi.org/10.1186/s13071-017-2529-2
- Author:
- Timothy C. Cameron; Ira Cooke; Pierre Faou; Hayley Toet; David Piedrafita; Neil Young; Vignesh Rathinasamy; Travis Beddoe; Glenn Anderson; Robert Dempster; Terry W. Spithill
- Source:
- International journal for parasitology 2017 v.47 no.9 pp. 555-567
- ISSN:
- 0020-7519
- Subject:
- Fasciola gigantica; Fasciola hepatica; adaptive immunity; adults; amino acids; antibodies; antigens; cytoskeleton; cytotoxicity; definitive hosts; exocytosis; fascioliasis; flukes; glucose transporters; immune response; immunoglobulin G; immunotherapy; juveniles; lysosomes; mass spectrometry; metacercariae; multiple drug resistance; protein secretion; sequence homology; sheep; vaccines; vacuoles
- Abstract:
- ... A more thorough understanding of the immunological interactions between Fasciola spp. and their hosts is required if we are to develop new immunotherapies to control fasciolosis. Deeper knowledge of the antigens that are the target of the acquired immune responses of definitive hosts against both Fasciola hepatica and Fasciola gigantica will potentially identify candidate vaccine antigens. Indones ...
- DOI:
- 10.1016/j.ijpara.2017.02.004
- https://doi.org/10.1016/j.ijpara.2017.02.004
- Author:
- Marcella Arciuli; Daniela Fiocco; Sergio Fontana; Mattia Pia Arena; Maria Antonia Frassanito; Anna Gallone
- Source:
- Fish & shellfish immunology 2017 v.68 pp. 404-410
- ISSN:
- 1050-4648
- Subject:
- Dicentrarchus labrax; Vitis vinifera; adaptive immunity; bass; biosynthesis; diet; enzyme activity; essential oils; flavanols; gene expression; health status; immune response; immunostimulants; innate immunity; juveniles; kidneys; melanin; pathogens; polyphenols; seeds; spleen; vaccines
- Abstract:
- ... The reinforcement of the defense mechanism of fish, through the administration of immunostimulants, is considered as a promising alternative to vaccines. Natural immunostimulants such as polyphenols, flavanoids, pigments and essential oils can modulate the innate immune response. In lower vertebrates, melano-macrophage centres, i.e. clusters of pigment-containing cells forming the extracutaneous p ...
- DOI:
- 10.1016/j.fsi.2017.07.043
- https://doi.org/10.1016/j.fsi.2017.07.043
- Author:
- Yu Zhang; Xijin Xu; Di Sun; Junjun Cao; Yuling Zhang; Xia Huo
- Source:
- Ecotoxicology and environmental safety 2017 v.145 pp. 615-622
- ISSN:
- 0147-6513
- Subject:
- adaptive immunity; atomic absorption spectrometry; basophils; cadmium; electronic wastes; eosinophils; flow cytometry; heavy metals; hematology; lead; monocytes; neutrophils; pollution; preschool children; recycling
- Abstract:
- ... Heavy metal lead (Pb) and cadmium (Cd) are widespread environmental contaminants and exert detrimental effects on the immune system. We evaluated the association between Pb/Cd exposures and innate immune cells in children from an electronic waste (e-waste) recycling area. A total number of 294 preschool children were recruited, including 153 children from Guiyu (e-waste exposed group), and 141 fro ...
- DOI:
- 10.1016/j.ecoenv.2017.07.059
- https://doi.org/10.1016/j.ecoenv.2017.07.059
- Author:
- James Venturini; Ricardo Souza Cavalcante; Daniela Vanessa Moris; Márjorie de Assis Golim; Adriele Dandara Levorato; Karoline Hagatha dos Reis; Maria Sueli Parreira de Arruda; Rinaldo Poncio Mendes
- Source:
- Acta tropica 2017 pp. -
- ISSN:
- 0001-706X
- Subject:
- Paracoccidioides; adaptive immunity; adults; blood serum; chemokine CCL3; complications (disease); dendritic cells; enzyme-linked immunosorbent assay; fibroblast growth factor 2; fibrosis; flow cytometry; fungi; hypoxia; immune response; interleukin-10; interleukin-18; interleukin-1beta; lungs; models; mucosa; mycoses; patients; pulmonary emphysema; tumor necrosis factor-alpha; Latin America
- Abstract:
- ... Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi from the genus Paracoccidioides in Latin America. PCM-patients (PCM-p) are classified as having acute/subacute or chronic (CF) clinical forms. CF is responsible for 75% − 90% of all cases, affects mainly adults over 30 years old and the clinical manifestation are associated mainly with lungs and mucosa of upper airdigestive tract. ...
- DOI:
- 10.1016/j.actatropica.2017.06.007
- https://doi.org/10.1016/j.actatropica.2017.06.007
- Author:
- J. W. Aleri; B. C. Hine; M. F. Pyman; P. D. Mansell; W. J. Wales; B. Mallard; A. D. Fisher
- Source:
- Animal production science 2017 v.57 no.2 pp. 244-251
- ISSN:
- 1836-0939
- Subject:
- Holstein; adaptive immunity; cortisol; cows; feed conversion; lactation; phenotype; vaccines
- Abstract:
- ... The objective of this study was to assess the immune and stress responsiveness of cows identified as extremely high and low feed conversion efficiency phenotypes. The study utilised 16 Holstein-Friesian cows in their third to fourth lactation, and identified as having either extremely high (n = 8) or extremely low (n = 8) feed conversion efficiency. A commercial vaccine was used to induce measurab ...
- DOI:
- 10.1071/AN15406
- https://doi.org/10.1071/AN15406
- Author:
- Madeleine Hamley; Frederik Franke; Joachim Kurtz; Jörn Peter Scharsack
- Source:
- Experimental parasitology 2017 pp. -
- ISSN:
- 0014-4894
- Subject:
- Gasterosteus aculeatus; Schistocephalus; adaptive immunity; allopatry; coevolution; excretory-secretory products; host-parasite relationships; hosts; leukocytes; sympatry; tapeworms; virulence; Germany; Iceland; Spain
- Abstract:
- ... The evolutionary arms race of hosts and parasites often results in adaptations, which may differ between populations. Investigation of such local adaptation becomes increasingly important to understand dynamics of host-parasite interactions and co-evolution. To this end we performed an infection experiment involving pairs of three-spined sticklebacks and their tapeworm parasite Schistocephalus sol ...
- DOI:
- 10.1016/j.exppara.2017.03.004
- https://doi.org/10.1016/j.exppara.2017.03.004
- Author:
- Hae Ji Kang; Young Woo Han; Su Jin Kim; You-Jin Kim; A-Reum Kim; Joo Ae Kim; Hee-Dong Jung; Hye Eun Eom; Ok Park; Sung Soon Kim
- Source:
- Vaccine 2017 v.35 no.33 pp. 4126-4132
- ISSN:
- 0264-410X
- Subject:
- adaptive immunity; adolescents; antibodies; enzyme immunoassays; herd immunity; infants; seroprevalence; surveys; vaccination; vaccines; viruses; young adults; Korean Peninsula
- Abstract:
- ... In Korea, measles occurs mainly in infants <12months of age, who are unvaccinated. In addition, vaccine populations, including adolescents and young adults, can become infected though importation. Thus, the question arises whether the current level of herd immunity in Korea is now insufficient for protecting against measles infection.Age-specific measles seroprevalence was evaluated by performing ...
- DOI:
- 10.1016/j.vaccine.2017.06.058
- https://doi.org/10.1016/j.vaccine.2017.06.058
- Author:
- Paul J. Conroy; Ruby H.P. Law; Tom T. Caradoc-Davies; James C. Whisstock
- Source:
- Methods 2017 v.116 pp. 12-22
- ISSN:
- 1046-2023
- Subject:
- adaptive immunity; antibodies; antigens; crystallography; high-throughput nucleotide sequencing; human health; humans; rodents; screening
- Abstract:
- ... Antibodies represent a highly successful class of molecules that bind a wide-range of targets in therapeutic-, diagnostic- and research-based applications. The antibody repertoire is composed of the building blocks required to develop an effective adaptive immune response against foreign insults. A number of species have developed novel genetic and structural mechanisms from which they derive thes ...
- DOI:
- 10.1016/j.ymeth.2017.01.003
- https://doi.org/10.1016/j.ymeth.2017.01.003
- Author:
- Gunay Gokhan; Sardan Ekiz Melis; Ferhati Xhenti; Richichi Barbara; Nativi Cristina; Tekinay Ayse B.; Guler Mustafa O.
- Source:
- ACS Applied Materials & Interfaces 2017 v.9 no.19 pp. 16035-16042
- ISSN:
- 1944-8252
- Subject:
- adaptive immunity; antigens; dendritic cells; glycopeptides; nanofibers; neoplasms; pathogens; vaccination
- Abstract:
- ... The ability of dendritic cells to coordinate innate and adaptive immune responses makes them essential targets for vaccination strategies. Presentation of specific antigens by dendritic cells is required for the activation of the immune system against many pathogens and tumors, and nanoscale materials can be functionalized for active targeting of dendritic cells. In this work, we integrated an imm ...
- DOI:
- 10.1021/acsami.7b04094
- https://doi.org/10.1021/acsami.7b04094
- Author:
- Yubao Cui; Jin‐Lu Sun; LiLi Yu
- Source:
- Entomologia experimentalis et applicata 2017 v.162 no.2 pp. 124-132
- ISSN:
- 0013-8703
- Subject:
- CRISPR sequences; DNA; Danio rerio; Diptera; Nematoda; adaptive immunity; bacteria; bacteriophages; gene editing; genome; humans; insects; mice; rats; ribonucleases; yeasts
- Abstract:
- ... The clustered regularly interspaced short palindromic repeats (CRISPR) structural family form an acquired immune system in bacteria that is able to degrade invading virus or phage DNA. The CRISPR/Cas system has been co‐opted as an RNA‐mediated nuclease for use in targeted genome engineering. The CRISPR/Cas system provides a novel tool for manipulating genomic DNA using an approach that is simple, ...
- DOI:
- 10.1111/eea.12530
- https://doi.org/10.1111/eea.12530
- Author:
- Ana R. J. Cabrita; Alexandra Correia; Ana R. Rodrigues; Paulo P. Cortez; Manuel Vilanova; António J.M. Fonseca
- Source:
- Journal of applied phycology 2017 v.29 no.2 pp. 1057-1067
- ISSN:
- 0921-8971
- Subject:
- B-lymphocytes; Gracilaria; Ulva rigida; adaptive immunity; alfalfa hay; diet; digestibility; digestible energy; ecosystems; hematologic tests; immune response; in vivo studies; macroalgae; neutrophils; organic matter; polysaccharides; reactive oxygen species; rumen; sheep
- Abstract:
- ... Ruminants could be the most suitable domestic animals to be supplemented with seaweeds as the rumen ecosystem might provide the animal the ability to use these feed resources by breaking down the complex polysaccharides. The objective of the present in vivo study was to determine the digestibility and the effects on the immune system of one green (Ulva rigida) and one red (Gracilaria vermiculophyl ...
- DOI:
- 10.1007/s10811-016-0999-9
- https://doi.org/10.1007/s10811-016-0999-9
- Author:
- Jing-Zhuang Zhao; Li-Ming Xu; Miao Liu; Zhen-yu Zhang; Jia-Sheng Yin; Hong-Bai Liu; Tong-Yan Lu
- Source:
- Developmental and comparative immunology 2017 v.77 pp. 88-94
- ISSN:
- 0145-305X
- Subject:
- Infectious hematopoietic necrosis virus; Salmonidae; Western blotting; adaptive immunity; aquaculture industry; autophagy; cell lines; disease severity; electron microscopy; fluorescence microscopy; pathogens; rapamycin; virus replication
- Abstract:
- ... Infectious hematopoietic necrosis virus (IHNV) is a common pathogen that causes severe disease in the salmonid aquaculture industry. Recent work demonstrated that autophagy plays an important role in pathogen invasion by activating innate and adaptive immunity. This study investigated the relationship between IHNV and autophagy in epithelioma papulosum cyprini cells. The electron microscopy result ...
- DOI:
- 10.1016/j.dci.2017.07.025
- https://doi.org/10.1016/j.dci.2017.07.025
- Author:
- Eun-Mi Kim; Eun-Hee Lee; Hwa-Yeon Lee; Ha-Rim Choi; Kon-Young Ji; Su-Man Kim; Kwang Dong Kim; Hyung-Sik Kang
- Source:
- Protoplasma 2017 v.254 no.2 pp. 1091-1101
- ISSN:
- 0033-183X
- Subject:
- adaptive immunity; antibodies; antigen-presenting cells; autoimmunity; bone marrow; cell viability; chemical elements; gene expression regulation; genes; hematopoietic stem cells; innate immunity; interferon-gamma; ligands; metastasis; mice; natural killer cells; neoplasm cells; receptor protein-tyrosine kinase; receptors
- Abstract:
- ... Natural killer (NK) cells have been well known to play a critical role in innate immunity, but they are also capable of regulating adaptive immunity through the induction of T cell-mediated memory response and B cell-mediated autoimmune response. NK cells are differentiated from hematopoietic stem cells (HSCs) in the bone marrow (BM), and a series of surface molecules are expressed on NK cells in ...
- DOI:
- 10.1007/s00709-016-1016-5
- https://doi.org/10.1007/s00709-016-1016-5
- Author:
- Carolina Sánchez-Rodríguez; Keyliz Peraza Cruces; Juan Riestra Ayora; Eduardo Martín-Sanz; Ricardo Sanz-Fernández
- Source:
- Vaccine 2017 v.35 no.47 pp. 6395-6403
- ISSN:
- 0264-410X
- Subject:
- BCG vaccine; CD8-positive T-lymphocytes; adaptive immunity; angiogenesis; angiopoietin-2; antigens; antineoplastic activity; apoptosis; caspase-3; coculture; cytotoxicity; endothelial cells; head; humans; immunosuppression; interferon-gamma; interleukin-6; models; morbidity; neck; patients; squamous cell carcinoma; tumor necrosis factor-alpha; vaccination; vascular endothelial growth factors
- Abstract:
- ... Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers worldwide and is associated with poor survival and significant treatment morbidity. The immune profile in patients with HNSCC is immunosuppressive and presents cytokine-mediated adaptive immune responses, triggered apoptosis of T cells, and alterations in antigen processing machinery. Bacille Calmette-Guerin (BCG) im ...
- DOI:
- 10.1016/j.vaccine.2017.10.008
- https://doi.org/10.1016/j.vaccine.2017.10.008
- Author:
- Aditya Kumar Sharma; Neha Dhasmana; Neha Dubey; Nishant Kumar; Aakriti Gangwal; Meetu Gupta; Yogendra Singh
- Source:
- Indian journal of microbiology 2017 v.57 no.1 pp. 1-10
- ISSN:
- 0046-8991
- Subject:
- Mycobacterium; adaptive immunity; adhesion; animal pathogens; bacteria; chemical elements; virulence
- Abstract:
- ... Virulence is described as an ability of an organism to infect the host and cause a disease. Virulence factors are the molecules that assist the bacterium colonize the host at the cellular level. These factors are either secretory, membrane associated or cytosolic in nature. The cytosolic factors facilitate the bacterium to undergo quick adaptive—metabolic, physiological and morphological shifts. T ...
- DOI:
- 10.1007/s12088-016-0625-1
- PubMed:
- 28148975
- PubMed Central:
- PMC5243249
- https://doi.org/10.1007/s12088-016-0625-1
- Author:
- Irshad A. Hajam; Pervaiz A. Dar; Gayeon Won; John Hwa Lee
- Source:
- Veterinary research 2017 v.48 no.1 pp. 37
- ISSN:
- 1297-9716
- Subject:
- B-lymphocytes; Gram-negative bacteria; adaptive immunity; adjuvants; agonists; animal models; antigens; cytokines; dendritic cells; immune response; immunostimulants; lymph nodes; transfection; vaccines
- Abstract:
- ... Bacterial ghosts (BG) are empty cell envelopes derived from Gram-negative bacteria. They contain many innate immunostimulatory agonists, and are potent activators of a broad range of cell types involved in innate and adaptive immunity. Several considerable studies have demonstrated the effectiveness of BG as adjuvants as well as their ability to induce proinflammatory cytokine production by a rang ...
- DOI:
- 10.1186/s13567-017-0442-5
- PubMed:
- 28645300
- PubMed Central:
- PMC5482964
- https://doi.org/10.1186/s13567-017-0442-5
- Author:
- Charlotte Volgers; Birke J. Benedikter; Gert E. Grauls; Paul H.M. Savelkoul; Frank R.M. Stassen
- Source:
- Microbiological research 2017 v.200 pp. 25-32
- ISSN:
- 0944-5013
- Subject:
- adaptive immunity; bacteria; environmental factors; flow cytometry; pathogenicity; screening
- Abstract:
- ... During infection, the release of nano-sized membrane vesicle is a process which is common both for bacteria and host cells. Host cell-derived membrane vesicles can be involved in innate and adaptive immunity whereas bacterial membrane vesicles can contribute to bacterial pathogenicity. To study the contribution of both membrane vesicle populations during infection is highly complicated as most ves ...
- DOI:
- 10.1016/j.micres.2017.04.003
- https://doi.org/10.1016/j.micres.2017.04.003
- Author:
- Bernd H.A. Rehm
- Source:
- Current opinion in biotechnology 2017 v.48 pp. 42-53
- ISSN:
- 0958-1669
- Subject:
- adaptive immunity; antigen-presenting cells; antigens; bioengineering; immune response; infectious diseases; pathogens; polyesters; proteins; subunit vaccines
- Abstract:
- ... There is an unmet demand for safe and efficient vaccines for prevention of various infectious diseases. Subunit vaccines comprise selected pathogen specific antigens are a safe alternative to whole organism vaccines. However they often lack immunogenicity. Natural and synthetic self-assembling polymers and proteins will be reviewed in view their use to encapsulate and/or display antigens to serve ...
- DOI:
- 10.1016/j.copbio.2017.03.018
- https://doi.org/10.1016/j.copbio.2017.03.018
- Author:
- Ankur Singh
- Source:
- Biomaterials 2017 pp. -
- ISSN:
- 0142-9612
- Subject:
- T-lymphocytes; adaptive immunity; animal models; biocompatible materials; immunomodulation; immunotherapy; lymphatic system; medicine; mice; natural selection; researchers; tissue culture; tissue engineering; tissues
- Abstract:
- ... Primary and secondary lymphoid organs are tissues that facilitate differentiation of B and T cells, leading to the induction of adaptive immune responses. These organs are present in the body from birth and are also recognized as locations where self-reactive B and T cells can be eliminated during the natural selection process. Many insights into the mechanisms that control the process of immune c ...
- DOI:
- 10.1016/j.biomaterials.2017.03.015
- https://doi.org/10.1016/j.biomaterials.2017.03.015
- Author:
- Jian Xu; Jing Wu; Bo Jiang; Houjun He; Xixi Zhang; Xiaoyang Li; Dawei Yang; Xiufen Huang; Joshua E. Sealy; Munir Iqbal; Yongqing Li
- Source:
- Applied microbiology and biotechnology 2017 v.101 no.23-24 pp. 8331-8344
- ISSN:
- 0175-7598
- Subject:
- epitopes; hybridomas; Bovine alphaherpesvirus 1; molecular models; glycoproteins; adaptive immunity; cattle; Western blotting; enzyme-linked immunosorbent assay; monoclonal antibodies; pathogenicity; genes; neutralizing antibodies; viruses; kidneys; recombinant antibodies; fluorescent antibody technique; Escherichia coli
- Abstract:
- ... Glycoprotein D (gD) of bovine herpesvirus-1 (BoHV-1) is essential for attachment and penetration of cells during infection and is a major target for neutralizing antibodies during an adaptive immune response. Currently there are no recombinant antibodies capable of binding gD epitopes for use in treating BoHV-1 infection. In this study, a bovine scFv gene derived from a hybridoma secreting monoclo ...
- DOI:
- 10.1007/s00253-017-8566-0
- https://doi.org/10.1007/s00253-017-8566-0
- Author:
- Raquel Ferraz; Clarissa F. Cunha; Maria Inês F. Pimentel; Marcelo R. Lyra; Tatiana Pereira-Da-Silva; Armando O. Schubach; Alda Maria Da-Cruz; Alvaro Luiz Bertho
- Source:
- Parasites & vectors 2017 v.10 no.1 pp. 219
- ISSN:
- 1756-3305
- Subject:
- CD8-positive T-lymphocytes; Leishmania braziliensis; adaptive immunity; cutaneous leishmaniasis; cytokines; cytotoxicity; dendritic cells; flow cytometry; immune response; inflammation; macrophages; natural killer cells; pathogenesis; patients; therapeutics
- Abstract:
- ... BACKGROUND: Cutaneous leishmaniasis (CL) is caused by Leishmania (Viannia) braziliensis, which infects dermal macrophages and dendritic cells, causing an intense immune-mediated-tissue inflammation and a skin ulcer with elevated borders that can heal spontaneously or after antimonial therapy. The resolution of lesions depends on an adaptive immune response, and cytotoxic cells seem to have a funda ...
- DOI:
- 10.1186/s13071-017-2152-2
- PubMed:
- 28468680
- PubMed Central:
- PMC5415843
- https://doi.org/10.1186/s13071-017-2152-2
- Author:
- Qiang Fu; Zigong Wei; Pingping Xiao; Yaosheng Chen; Xiaohong Liu
- Source:
- Veterinary microbiology 2017 v.198 pp. 121-126
- ISSN:
- 0378-1135
- Subject:
- Streptococcus equi subsp. zooepidemicus; adaptive immunity; death; macrophages; mice; pathogens; phagocytosis; protective effect
- Abstract:
- ... Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is an important pathogen associated with a wide range of diseases in many mammalian species. CD44 is a transmembrane adhesion molecule involved in innate and adaptive immune responses. The aim of this study was to determine the protective role of CD44 during S. zooepidemicus infection. CD44-deficient mice exhibited reduced macrophage accum ...
- DOI:
- 10.1016/j.vetmic.2016.12.030
- https://doi.org/10.1016/j.vetmic.2016.12.030
- Author:
- Clauvis Nji Tizi Taning; Benigna Van Eynde; Na Yu; Sanyuan Ma; Guy Smagghe
- Source:
- Journal of insect physiology 2017 v.98 pp. 245-257
- ISSN:
- 0022-1910
- Subject:
- applied research; adaptive immunity; gene editing; biosafety; genes; insect physiology; RNA; insects
- Abstract:
- ... Discovered as a bacterial adaptive immune system, CRISPR/Cas9 (clustered, regularly interspaced, short palindromic repeat/CRISPR associated) is being developed as an attractive tool in genome editing. Due to its high specificity and applicability, CRISPR/Cas9-mediated gene editing has been employed in a multitude of organisms and cells, including insects, for not only fundamental research such as ...
- DOI:
- 10.1016/j.jinsphys.2017.01.007
- https://doi.org/10.1016/j.jinsphys.2017.01.007
30. Characteristics of NK cells from leukemic microenvironment in MLL-AF9 induced acute myeloid leukemia
- Author:
- Feifei Yang; Rong Wang; Wenli Feng; Chong Chen; Xiao Yang; Lina Wang; Yuting Hu; Qian Ren; Guoguang Zheng
- Source:
- Molecular Immunology 2017 pp. -
- ISSN:
- 0161-5890
- Subject:
- CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; adaptive immunity; cytokines; cytotoxicity; mice; models; myeloid leukemia; natural killer cells; phenotype; spleen
- Abstract:
- ... NK cells are indispensable components of tissue microenvironment and play vital in both innate and adaptive immunity. The activation and function of NK cells are affected by tumor microenvironments. NK cells are also important players in leukemic microenvironment. However, their characteristics in leukemic microenvironment, including maturation status, phenotype, subpopulations and functional role ...
- DOI:
- 10.1016/j.molimm.2017.11.003
- https://doi.org/10.1016/j.molimm.2017.11.003
- Author:
- Harold Marcotte; Kasper Krogh Andersen; Yin Lin; Fanglei Zuo; Zhu Zeng; Per Göran Larsson; Erik Brandsborg; Gunnar Brønstad; Lennart Hammarström
- Source:
- Microbiological research 2017 v.205 pp. 88-98
- ISSN:
- 0944-5013
- Subject:
- Gardnerella vaginalis; Lactobacillus gasseri; Lactobacillus rhamnosus; acidification; adaptive immunity; adhesins; adhesion; amino acids; antibiotic resistance; antibiotics; antimicrobial properties; bacteria; biosynthesis; culture media; epithelial cells; exopolysaccharides; fimbriae; genetic resistance; human cell lines; hydrogen peroxide; multigene family; nucleotide sequences; pH; probiotics; relapse; sequence analysis; therapeutics; women
- Abstract:
- ... Lactobacillus rhamnosus DSM 14870 and Lactobacillus gasseri DSM 14869 were previously isolated from the vaginal epithelial cells (VEC) of healthy women and selected for the development of the vaginal EcoVag® probiotic capsules. EcoVag® was subsequently shown to provide long-term cure and reduce relapse of bacterial vaginosis (BV) as an adjunct to antibiotic therapy. To identify genes potentially i ...
- DOI:
- 10.1016/j.micres.2017.08.003
- https://doi.org/10.1016/j.micres.2017.08.003
- Author:
- Young Kyu Kim; Jung Seok Lee; Jae Wook Jung; Jun-ichi Hikima; Maki Ohtani; Ho Bin Jang; Seong Won Nho; In Seok Cha; Seong Bin Park; Jeong Ho Lee; Takashi Aoki; Tae Sung Jung
- Source:
- Fish & shellfish immunology 2017 v.60 pp. 88-96
- ISSN:
- 1050-4648
- Subject:
- Paralichthys olivaceus; adaptive immunity; flounder; immune response; immunoglobulins; lymphocytes; mammals; monoclonal antibodies; spleen
- Abstract:
- ... Immunoglobulins (Ig) are heterodimeric proteins that play critical roles in the adaptive immune system of vertebrates. Because of their plasticity, teleostean Igs are more diverse, and thus do not conform to mammalian classifications. Because of this, mammalian-based Ig cell markers cannot be used successfully to study immune responses in fish. There is therefore a need to produce Ig-specific cell ...
- DOI:
- 10.1016/j.fsi.2016.11.023
- https://doi.org/10.1016/j.fsi.2016.11.023
- Author:
- Carolina S. Andreotti; Celina Baravalle; Sofía C. Sacco; Melisa Lovato; Elizabet A.L. Pereyra; María S. Renna; Hugo H. Ortega; Luis F. Calvinho; Bibiana E. Dallard
- Source:
- Comparative immunology, microbiology, and infectious diseases 2017 v.54 pp. 51-60
- ISSN:
- 0147-9571
- Subject:
- B-lymphocytes; Holstein; Staphylococcus aureus; T-lymphocytes; Toll-like receptor 2; Toll-like receptor 4; adaptive immunity; chronic diseases; cows; disease control; immune response; immunohistochemistry; interleukin-17; lactoferrin; late lactation; mammary glands; milking; protein synthesis; tumor necrosis factor-alpha
- Abstract:
- ... The aim of this study was to characterize the immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution. Twenty-one Holstein non-pregnant cows in late lactation either uninfected or with chronic naturally acquired S. aureus intramammary infections (IMI) were included in this study. Cows were slaughtered at 7, 14 and 21 d after cessation of milking ...
- DOI:
- 10.1016/j.cimid.2017.08.005
- https://doi.org/10.1016/j.cimid.2017.08.005
- Author:
- Drashti R. Parmar; Siuli Mitra; Snehalata Bhadouriya; Tirupathi Rao; Vaishnavi Kunteepuram; Ajay Gaur
- Source:
- Genetica 2017 v.145 no.6 pp. 541-558
- ISSN:
- 0016-6707
- Subject:
- Panthera pardus; adaptive immunity; alleles; amino acids; antigens; disease outbreaks; genetic variation; loci; major histocompatibility complex; phylogeny; receptors; vertebrates
- Abstract:
- ... The major histocompatibility complex (MHC), in vertebrate animals, is a multi-genic protein complex that encodes various receptors. During a disease, MHC interacts with the antigen and triggers a cascade of adaptive immune responses to overcome a disease outbreak. The MHC is very important region from immunological point of view, but it is poorly characterized among Indian leopards. During this in ...
- DOI:
- 10.1007/s10709-017-9979-5
- https://doi.org/10.1007/s10709-017-9979-5
- Author:
- Shayan Chen; Xiao Yang; Wenli Feng; Feifei Yang; Rong Wang; Chong Chen; Lina Wang; Yongmin Lin; Qian Ren; Guoguang Zheng
- Source:
- Molecular Immunology 2017 v.81 pp. 35-41
- ISSN:
- 0161-5890
- Subject:
- T-lymphocytes; adaptive immunity; gene expression; genes; inducible nitric oxide synthase; lymphocytic leukemia; macrophages; mice; models; phenotype; spleen; transforming growth factor beta 1; vascular endothelial growth factor A
- Abstract:
- ... Macrophages, which have remarkable plasticity, are indispensable cellular components and play essential roles in both innate and adaptive immune responses. Peritoneal macrophages show unique gene expression profile and peritoneal cavity is also involved in leukemia. However, the characteristics of peritoneal leukemia-associated macrophages (Per LAMs) have not been established. Here we studied the ...
- DOI:
- 10.1016/j.molimm.2016.11.014
- https://doi.org/10.1016/j.molimm.2016.11.014
- Author:
- Chong Han; Qiang Li; Zhipeng Zhang; Jianrong Huang
- Source:
- Developmental and comparative immunology 2017 v.77 pp. 174-187
- ISSN:
- 0145-305X
- Subject:
- Mastacembelus armatus; Toll-like receptor 3; Vibrio parahaemolyticus; adaptive immunity; amphibians; coevolution; eel; liver; models; pathogens; reptiles; spleen; tissues
- Abstract:
- ... Toll-like receptors (TLRs) play an important role in innate and adaptive immunity. Here, we identify two new TLRs from the spiny eel Mastacembelus armatus (TLR3 and membrane TLR5M). Both MaTLR3 and MaTLR5M were expressed in all tested tissues; expression was highest in liver and spleen, respectively. After infection with Vibrio parahaemolyticus, expression of both TLRs fluctuated and differed sign ...
- DOI:
- 10.1016/j.dci.2017.08.007
- https://doi.org/10.1016/j.dci.2017.08.007
- Author:
- Wenshi Li; Xixiang Tang; Yan Chen; Wanwei Sun; Yan Liu; Yi Gong; Xiaobo Wen; Shengkang Li
- Source:
- Fish & shellfish immunology 2017 v.71 pp. 305-318
- ISSN:
- 1050-4648
- Subject:
- Down syndrome; Scylla paramamosain; Vibrio parahaemolyticus; adaptive immunity; alternative splicing; amino acids; antibodies; arthropods; binding capacity; brain; cell adhesion molecules; complementary DNA; crabs; exons; fibronectins; heart; hemolymph; hepatopancreas; immunoglobulins; innate immunity; intestines; muscles; open reading frames; pathogens; quantitative polymerase chain reaction
- Abstract:
- ... As a member of the immunoglobulin superfamily, Down syndrome cell adhesion molecule (Dscam) could function in the innate immunity of invertebrates. Recently, it is shown that arthropod Dscams play similar functions as antibodies in the adaptive immune system. Dscam could produce thousands of isoforms by alternative splicing and specifically bind to various pathogens. In the present study, we clone ...
- DOI:
- 10.1016/j.fsi.2017.10.023
- https://doi.org/10.1016/j.fsi.2017.10.023
- Author:
- M. R. Perez-Gregorio; R. Días; N. Mateus; V. de Freitas
- Source:
- Food & function 2017 v.8 no.8 pp. 2712-2721
- ISSN:
- 2042-650X
- Subject:
- Western blotting; adaptive immunity; celiac disease; enzyme-linked immunosorbent assay; epitopes; gliadin; glutenins; high performance liquid chromatography; peptides; prolamins; proteomics; tandem mass spectrometry; wheat flour; wheat gluten; wheat protein
- Abstract:
- ... Immunogenic gluten peptides trigger Celiac Disease (CD), an adaptive immune response in genetically predisposed individuals. Given the structural similarity between all gluten proteins their individual CD influence is not clear. Hence, the extraction, separation and characterization of wheat gluten proteins have become relevant to measure their individual potential immunoreactivity. Wheat proteins ...
- DOI:
- 10.1039/c7fo00266a
- https://doi.org/10.1039/c7fo00266a
- Author:
- Peng Fei Zou; Xue Na Huang; Cui Luan Yao; Qing Xue Sun; Ying Li; Qian Zhu; Zhen Xing Yu; Ze Jun Fan
- Source:
- Fish & shellfish immunology 2017 v.63 pp. 452-464
- ISSN:
- 1050-4648
- Subject:
- transcription factor NF-kappa B; liver; fluorescence microscopy; protein kinases; interleukins; muscles; adaptive immunity; signal transduction; Larimichthys crocea; spleen; cytoplasm; Vibrio parahaemolyticus; exons; fish; immune response; blood; introns; Toll-like receptors
- Abstract:
- ... As crucial signaling transducer in Toll-like receptor (TLR) and interleukin (IL)-1 receptor (IL-1R) signaling pathway, IL-1R-associated kinase 4 (IRAK4) mediates downstream signaling cascades and plays important roles in innate and adaptive immune responses. In the present study, an IRAK4 orthologue was characterized from large yellow croaker (Larimichthys crocea), named Lc-IRAK4, with a conservat ...
- DOI:
- 10.1016/j.fsi.2016.12.019
- https://doi.org/10.1016/j.fsi.2016.12.019
- Author:
- Quanxin Gao; Fei Yin; Chenjie Zhang; Yanfeng Yue; Peng Sun; Minghua Min; Shiming Peng; Zhaohong Shi; Jing Lv
- Source:
- International journal of biological macromolecules 2017 pp. -
- ISSN:
- 0141-8130
- Subject:
- Bramidae; Pampus argenteus; Toll-like receptor 2; Toll-like receptor 4; adaptive immunity; amino acid sequences; apoptosis; bacteria; complementary DNA; messenger RNA; open reading frames; phylogeny; probiotics; reverse transcriptase polymerase chain reaction; sequence alignment; signal transduction; transcription (genetics)
- Abstract:
- ... Myeloid differentiation factor 88 (MyD88) is a key and universal downstream adapter for most Toll-like receptors (TLRs) and plays an important role in both the innate and adaptive immune response. In this study, the full-length cDNA of MyD88 (PAMyD88) from silvery pomfret (Pampus argenteus) was cloned and characterized. The PAMyD88 cDNA is 1545bp in length and contains an 876bp open reading frames ...
- DOI:
- 10.1016/j.ijbiomac.2017.05.039
- https://doi.org/10.1016/j.ijbiomac.2017.05.039
- Author:
- Asmita Pramanik; Dibyendu Paik; Kshudiram Naskar; Tapati Chakraborti
- Source:
- Current microbiology 2017 v.74 no.1 pp. 59-67
- ISSN:
- 0343-8651
- Subject:
- Coccinia grandis; Leishmania donovani; adaptive immunity; anti-infective agents; antiparasitic properties; cytotoxicity; humans; immunomodulators; inflammation; inhibitory concentration 50; interleukin-10; interleukin-12; leaf extracts; macrophages; mice; models; nitric oxide; parasite load; parasites; proteinase inhibitors; reactive oxygen species; serine proteinases; transforming growth factor beta; tumor necrosis factor-alpha; visceral leishmaniasis
- Abstract:
- ... The conventional drugs used for the treatment of human visceral leishmaniasis have concerns about the toxicity and most importantly parasite resistance. To overcome these troubles, more efforts are made for the development of innovative therapeutic agents having effective antileishmanial activity and simultaneously stimulate adaptive immune system of host cells. Hence, search for new leishmanicida ...
- DOI:
- 10.1007/s00284-016-1151-4
- https://doi.org/10.1007/s00284-016-1151-4
- Author:
- Juntao Shen; Li Lv; Xudong Wang; Zhilong Xiu; Guoqiang Chen
- Source:
- Journal of basic microbiology 2017 v.57 no.4 pp. 325-336
- ISSN:
- 0233-111X
- Subject:
- Klebsiella pneumoniae; adaptive immunity; bacteria; cross infection; essential genes; plasmids; secondary infection
- Abstract:
- ... Prokaryotic CRISPR‐Cas system provides adaptive immunity against invasive genetic elements. Bacteria of the genus Klebsiella are important nosocomial opportunistic pathogens. However, information of CRISPR‐Cas system in Klebsiella remains largely unknown. Here, we analyzed the CRISPR‐Cas systems of 68 complete genomes of Klebsiella representing four species. All the elements for CRISPR‐Cas system ...
- DOI:
- 10.1002/jobm.201600589
- https://doi.org/10.1002/jobm.201600589
- Author:
- Siddappa Manjunath; Bishnu Prasad Mishra; Bina Mishra; Aditya Prasad Sahoo; Ashok K. Tiwari; Kaushal Kishore Rajak; D. Muthuchelvan; Shikha Saxena; Lakshman Santra; Amit Ranjan Sahu; Sajad Ahmad Wani; R.P. Singh; Y.P. Singh; Aruna Pandey; Sonam Kanchan; R.K. Singh; Gandham Ravi Kumar; Sarath Chandra Janga
- Source:
- Virus research 2017 v.229 pp. 28-40
- ISSN:
- 0168-1702
- Subject:
- goats; signal transduction; genes; vaccination; mononuclear leukocytes; interferons; adaptive immunity; cytokines; gene expression; viruses; gene expression regulation; temporal variation; transcriptomics; Small ruminant morbillivirus; immune response; interferon regulatory factors; peste des petits ruminants; quantitative polymerase chain reaction; complement; innate immunity; sheep; vaccines; inflammation; reverse transcriptase polymerase chain reaction; India
- Abstract:
- ... Peste des petits ruminanats virus (PPRV), a morbillivirus causes an acute, highly contagious disease – peste des petits ruminants (PPR), affecting goats and sheep. Sungri/96 vaccine strain is widely used for mass vaccination programs in India against PPR and is considered the most potent vaccine providing long-term immunity. However, occurrence of outbreaks due to emerging PPR viruses may be a cha ...
- DOI:
- 10.1016/j.virusres.2016.12.014
- https://doi.org/10.1016/j.virusres.2016.12.014
- Author:
- Kar-Wai Hong; A.W. Asmah Hani; C.A. Nurul Aina Murni; R.R. Pusparani; Chee Kheong Chong; Khebir Verasahib; Wan Noraini W. Yusoff; Noorliza M. Noordin; Kok Keng Tee; Wai-Fong Yin; Choo Yee Yu; Geik Yong Ang; Kok-Gan Chan
- Source:
- Infection, genetics, and evolution 2017 v.54 pp. 263-270
- ISSN:
- 1567-1348
- Subject:
- Corynebacterium diphtheriae; DNA; adaptive immunity; chromosomes; genes; genetic relationships; genomics; herd immunity; monitoring; nucleotide sequences; phylogeny; toxigenic strains; Malaysia
- Abstract:
- ... In this study, we report the comparative genomics and phylogenetic analysis of Corynebacterium diphtheriae strain B-D-16-78 that was isolated from a clinical specimen in 2016. The complete genome of C. diphtheriae strain B-D-16-78 was sequenced using PacBio Single Molecule, Real-Time sequencing technology and consists of a 2,474,151-bp circular chromosome with an average GC content of 53.56%. The ...
- DOI:
- 10.1016/j.meegid.2017.07.015
- https://doi.org/10.1016/j.meegid.2017.07.015
- Author:
- Aneesh VIJAYAN; Martin RUMBO; Christophe CARNOY; Jean-Claude SIRARD
- Source:
- Trends in microbiology 2017 pp. -
- ISSN:
- 0966-842X
- Subject:
- CD4-positive T-lymphocytes; Toll-like receptor 5; adaptive immunity; bacteria; dendritic cells; epithelial cells; flagellin; flagellum; innate immunity; mucosa; niches; pathogenicity; pathogens
- Abstract:
- ... Motility is often a pathogenicity determinant of bacteria targeting mucosal tissues. Flagella constitute the machinery that propels bacteria into appropriate niches. Besides motility, the structural component flagellin, which forms flagella, targets Toll-like receptor 5 (TLR5) to activate innate immunity. The compartmentalization of flagellin-mediated immunity and the contribution of epithelial ce ...
- DOI:
- 10.1016/j.tim.2017.10.008
- https://doi.org/10.1016/j.tim.2017.10.008
- Author:
- Raffaella Parente; Simon J. Clark; Antonio Inforzato; Anthony J. Day
- Source:
- Cellular and molecular life sciences 2017 v.74 no.9 pp. 1605-1624
- ISSN:
- 1420-682X
- Subject:
- adaptive immunity; complement; cytotoxicity; homeostasis; immune evasion; immune response; infectious diseases; innate immunity; macular degeneration; mutation; neoplasm cells; neoplasms; pathogens; pathophysiology
- Abstract:
- ... Complement is the major humoral component of the innate immune system. It recognizes pathogen- and damage-associated molecular patterns, and initiates the immune response in coordination with innate and adaptive immunity. When activated, the complement system unleashes powerful cytotoxic and inflammatory mechanisms, and thus its tight control is crucial to prevent damage to host tissues and allow ...
- DOI:
- 10.1007/s00018-016-2418-4
- PubMed:
- 27942748
- PubMed Central:
- PMC5378756
- https://doi.org/10.1007/s00018-016-2418-4
- Author:
- M. Kathryn Liszewski; Michelle Elvington; Hrishikesh S. Kulkarni; John P. Atkinson
- Source:
- Molecular Immunology 2017 pp. -
- ISSN:
- 0161-5890
- Subject:
- T-lymphocytes; adaptive immunity; complement; immune response; pathogens; protein secretion; receptors; therapeutics
- Abstract:
- ... A key component of both innate and adaptive immunity, new understandings of the complement system are expanding its roles beyond that traditionally appreciated. Evidence is accumulating that complement has an intracellular arsenal of components that provide not only immune defense, but also assist in key interactions for host cell functions. Although early work has primarily centered on T cells, t ...
- DOI:
- 10.1016/j.molimm.2017.01.004
- PubMed:
- 28196665
- PubMed Central:
- PMC5373558
- https://doi.org/10.1016/j.molimm.2017.01.004
- Author:
- Junchao Duan; Yang Yu; Yang Li; Li Jing; Man Yang; Ji Wang; Yanbo Li; Xianqing Zhou; Mark R. Miller; Zhiwei Sun
- Source:
- Science of the total environment 2017 v.586 pp. 666-674
- ISSN:
- 0048-9697
- Subject:
- Danio rerio; adaptive immunity; atherosclerosis; autophagy; cytochrome P-450; dose response; fish; gene expression regulation; genes; humans; hypertension; metabolism; microRNA; models; myocardial infarction; neoplasms; particulates; public health; toxicity; transcription (genetics); vasodilation; xenobiotics
- Abstract:
- ... PM2.5 is a major public health concern and some severe diseases have been attributed to exposure to PM2.5. However, a comprehensive understanding of gene and microRNA expression patterns induced by PM2.5 is missing. The objective of this study was to evaluate the toxicity of PM2.5 via genome-wide transcriptional analysis in the model teleost fish, zebrafish (Danio rerio). Gene ontology analysis re ...
- DOI:
- 10.1016/j.scitotenv.2017.02.042
- https://doi.org/10.1016/j.scitotenv.2017.02.042
- Author:
- Jose Ricardo Morales Poole; Julien Paganini; Pierre Pontarotti
- Source:
- Developmental and comparative immunology 2017 v.75 pp. 120-126
- ISSN:
- 0145-305X
- Subject:
- B-lymphocytes; T-lymphocytes; adaptive immunity; convergent evolution; enzymes; vertebrates
- Abstract:
- ... Two different adaptive immune systems (AIS) are present in the two phyla of vertebrates (jawed vertebrates and cyclostomes). The jawed vertebrate system is based on IG/TCR/RAG/MHC while the cyclostome system is based on VLRCs and AID-like enzymes both systems using homologous Cell types (B-cell and B-cell Like, T-cell and T-cell like).We will present our current view of the evolution of these two ...
- DOI:
- 10.1016/j.dci.2017.02.011
- https://doi.org/10.1016/j.dci.2017.02.011
- Author:
- Eugene V. Koonin; Feng Zhang
- Source:
- BioEssays 2017 v.39 no.1 pp. 1-9
- ISSN:
- 0265-9247
- Subject:
- Archaea; RNA; adaptive immunity; apoptosis; bacteria; dormancy; evolution; genes; parasites; prokaryotic cells; proteins; reproduction; suicide
- Abstract:
- ... Host‐pathogen arms race is a universal, central aspect of the evolution of life. Most organisms evolved several distinct yet interacting strategies of anti‐pathogen defense including resistance to parasite invasion, innate and adaptive immunity, and programmed cell death (PCD). The PCD is the means of last resort, a suicidal response to infection that is activated when resistance and immunity fail ...
- DOI:
- 10.1002/bies.201600179
- PubMed:
- 28004447
- PubMed Central:
- PMC5319824
- https://doi.org/10.1002/bies.201600179
- Author:
- Rita Nocerino; Lorella Paparo; Gianluca Terrin; Vincenza Pezzella; Antonio Amoroso; Linda Cosenza; Gaetano Cecere; Giulio De Marco; Maria Micillo; Fabio Albano; Rosa Nugnes; Pasqualina Ferri; Giuseppe Ciccarelli; Giuliana Giaccio; Raffaella Spadaro; Ylenia Maddalena; Francesco Berni Canani; Roberto Berni Canani
- Source:
- Clinical nutrition 2017 v.36 pp. 118-125
- ISSN:
- 0261-5614
- Subject:
- Lactobacillus paracasei; adaptive immunity; biomarkers; cathelicidins; children; fermented foods; gastroenteritis; immunoglobulin A; infectious diseases; males; milk; pediatricians; placebos; randomized clinical trials; respiratory tract diseases; rice; winter
- Abstract:
- ... Fermented foods have been proposed for the prevention of infectious diseases. We evaluated the efficacy of fermented foods in reducing common infectious diseases (CIDs) in children attending daycare.Prospective randomized, double-blind, placebo-controlled trial (registered under Clinical Trials.gov identifier NCT01909128) on healthy children (aged 12–48 months) consuming daily cow's milk (group A) ...
- DOI:
- 10.1016/j.clnu.2015.12.004
- https://doi.org/10.1016/j.clnu.2015.12.004
- Author:
- Myung-Hwa Jung; Sung-Ju Jung
- Source:
- Fish & shellfish immunology 2017 v.69 pp. 247-257
- ISSN:
- 1050-4648
- Subject:
- Oplegnathus fasciatus; Rock bream iridovirus; adaptive immunity; bream; caspases; cell death; gene expression regulation; genes; immune response; innate immunity; interleukin-1beta; ligands; mortality; oligodeoxyribonucleotides; viral load; viruses; Korean Peninsula
- Abstract:
- ... Rock bream iridovirus (RBIV) causes severe mass mortalities in rock bream in Korea. CpG ODN 1668 showed promise as immunoprotective agents against RBIV infection in rock bream. In this study, we assessed innate/adaptive-related gene expression patterns in RBIV-infected rock bream with and without CpG ODN 1668 administration to determine important immune defense related factors that may affect fish ...
- DOI:
- 10.1016/j.fsi.2017.08.030
- https://doi.org/10.1016/j.fsi.2017.08.030
- Author:
- Stamogiannos Athanasios; Maben Zachary; Papakyriakou Athanasios; Mpakali Anastasia; Kokkala Paraskevi; Georgiadis Dimitris; Stern Lawrence J.; Stratikos Efstratios
- Source:
- Biochemistry 2017 v.56 no.10 pp. 1546-1558
- ISSN:
- 1520-4995
- Subject:
- X-radiation; X-ray diffraction; active sites; adaptive immunity; aminopeptidases; catalytic activity; dissociation; electrostatic interactions; endoplasmic reticulum; epitopes; molecular dynamics; peptides; site-directed mutagenesis
- Abstract:
- ... Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an intracellular enzyme that is important for the generation of antigenic epitopes and major histocompatibility class I-restricted adaptive immune responses. ERAP1 processes a vast variety of different peptides but still shows length and sequence selectivity, although the mechanism behind these properties is poorly understood. X-ray crystallographi ...
- DOI:
- 10.1021/acs.biochem.6b01170
- PubMed:
- 28218509
- PubMed Central:
- PMC6374128
- https://doi.org/10.1021/acs.biochem.6b01170
- Author:
- Tai Wei Guo; Alberto Bartesaghi; Hui Yang; Veronica Falconieri; Prashant Rao; Alan Merk; Edward T. Eng; Ashleigh M. Raczkowski; Tara Fox; Lesley A. Earl; Dinshaw J. Patel; Sriram Subramaniam
- Source:
- Cell 2017 v.171 pp. 414-426.e12
- ISSN:
- 0092-8674
- Subject:
- DNA; RNA; RNA interference; Yersinia; cryo-electron microscopy; gene editing; immune system; monitoring; prokaryotic cells; viruses
- Abstract:
- ... Prokaryotic cells possess CRISPR-mediated adaptive immune systems that protect them from foreign genetic elements, such as invading viruses. A central element of this immune system is an RNA-guided surveillance complex capable of targeting non-self DNA or RNA for degradation in a sequence- and site-specific manner analogous to RNA interference. Although the complexes display considerable diversity ...
- DOI:
- 10.1016/j.cell.2017.09.006
- PubMed:
- 28985564
- PubMed Central:
- PMC5683424
- https://doi.org/10.1016/j.cell.2017.09.006
55. DNA Vaccination Partially Protects Muskellunge against Viral Hemorrhagic Septicemia Virus (VHSV-IVb)
- Author:
- Elena V. Millard; Ashley M. Bourke; Scott E. LaPatra; Travis O. Brenden; Scott D. Fitzgerald; Mohamed Faisal
- Source:
- Journal of Aquatic Animal Health 2017 v.29 no.1 pp. 50-56
- ISSN:
- 1548-8667
- Subject:
- Esox masquinongy; Infectious hematopoietic necrosis virus; Oncorhynchus mykiss; Viral hemorrhagic septicemia virus; adaptive immunity; fish; genes; genotype; glycoproteins; heat sums; immune response; neutralizing antibodies; plasmids; recombinant vaccines; vaccination; vaccine development; viral load
- Abstract:
- ... A DNA vaccine containing the glycoprotein (G) gene of the North American viral hemorrhagic septicemia virus (VHSV) genotype IVb was developed to evaluate the immune response of fish following vaccination and evaluate its efficacy in protecting a susceptible species, the Muskellunge Esox masquinongy , against VHSV-IVb challenge. Seven weeks (539 degree-days) following vaccination with 10 μg of eith ...
- DOI:
- 10.1080/08997659.2016.1238413
- https://doi.org/10.1080/08997659.2016.1238413
- Author:
- Naoko Kono; Lin Sun; Hiroyuki Toh; Takeyuki Shimizu; Hanbing Xue; Osamu Numata; Manabu Ato; Kazuo Ohnishi; Shigeyuki Itamura
- Source:
- Biochemical and biophysical research communications 2017 pp. -
- ISSN:
- 0006-291X
- Subject:
- adaptive immunity; antibodies; antigens; chickens; enzyme-linked immunosorbent assay; gamma-globulins; high-throughput nucleotide sequencing; immunoglobulin G; immunoglobulin M; mice; models
- Abstract:
- ... Vast diversity and high specificity of antigen recognition by antibodies are hallmarks of the acquired immune system. Although the molecular mechanisms that yield the extremely large antibody repertoires are precisely understood, comprehensive description of the global antibody repertoire generated in individual bodies has been hindered by the lack of powerful measures. To obtain holistic understa ...
- DOI:
- 10.1016/j.bbrc.2017.04.054
- https://doi.org/10.1016/j.bbrc.2017.04.054
- Author:
- Rong Zhu; Xiao-Xiao Liu; Xue Lv; Shun-Yi Li; Ya-Dong Li; Xue-Jing Yu; Xing-Guo Wang
- Source:
- Fish & shellfish immunology 2017 v.70 pp. 593-608
- ISSN:
- 1050-4648
- Subject:
- B-lymphocytes; Edwardsiella ictaluri; T-lymphocytes; Tachysurus fulvidraco; adaptive immunity; aquaculture; coagulation; complement; disease control programs; fish; gene expression; gene expression regulation; genes; microsatellite repeats; pathogens; signal transduction; transcriptomics; China
- Abstract:
- ... Edwardsiella ictaluri is one of the most important pathogens posing a serious threat for yellow catfish (Pelteobagrus fulvidraco), a highly valuable fish species of increasing commercial interest in China. Here, a transcriptomic strategy was undertaken to investigate the yellow catfish gene expression profile against infection by the bacterial pathogen E. ictaluri. Comparison of the transcriptome ...
- DOI:
- 10.1016/j.fsi.2017.08.040
- https://doi.org/10.1016/j.fsi.2017.08.040
- Author:
- Xinjiang Lin; Xijin Xu; Xiang Zeng; Long Xu; Zhijun Zeng; Xia Huo
- Source:
- Environmental pollution 2017 v.220 pp. 354-363
- ISSN:
- 0269-7491
- Subject:
- adaptive immunity; antibodies; arsenic; blood; body mass index; cadmium; chromium; chronic exposure; copper; electronic wastes; encephalitis; heavy metals; hepatitis B; lead; manganese; measles; mercury; nickel; preschool children; recycling; regression analysis; risk factors; selenium; tetanus; vaccination; vaccines; zinc; China
- Abstract:
- ... We explored acquired immunity resulting from vaccination in 3 to 7-year-old children, chronically exposed to multiple heavy metals and metalloids, in an e-waste recycling area (Guiyu, China). Child blood levels of ten heavy metals and metalloids, including lead (Pb), arsenic (As), mercury (Hg), chromium (Cr), cadmium (Cd), manganese (Mn), nickel (Ni), copper (Cu), zinc (Zn) and selenium (Se), and ...
- DOI:
- 10.1016/j.envpol.2016.09.071
- https://doi.org/10.1016/j.envpol.2016.09.071
- Author:
- Mona O. Mohsen; Ariane C. Gomes; Gustavo Cabral-Miranda; Caroline C. Krueger; Fabiana MS Leoratti; Jens V. Stein; Martin F. Bachmann
- Source:
- Journal of Controlled Release 2017 pp. -
- ISSN:
- 0168-3659
- Subject:
- DNA; Toll-like receptor 9; adaptive immunity; adjuvants; antigens; cytokines; dendritic cells; deoxyribonucleases; endosomes; immune response; immunostimulants; lymph nodes; macrophages; medicine; nanoparticles; vaccination; virus-like particle vaccines; virus-like particles
- Abstract:
- ... DNA rich in unmethylated CG motifs (CpGs) engage Toll-Like Receptor 9 (TLR-9) in endosomes and are well described stimulators of the innate and adaptive immune system. CpGs therefore can efficiently improve vaccines' immunogenicity. Packaging CpGs into nanoparticles, in particular into virus-like particles (VLPs), improves the pharmacological characteristics of CpGs as the protein shell protects t ...
- DOI:
- 10.1016/j.jconrel.2017.02.031
- https://doi.org/10.1016/j.jconrel.2017.02.031
- Author:
- Chang Liu; Li Zhang; Hao Liu; Kun Cheng
- Source:
- Journal of Controlled Release 2017 pp. -
- ISSN:
- 0168-3659
- Subject:
- Archaea; RNA; T-lymphocytes; adaptive immunity; bacteria; bacteriophages; clinical trials; eukaryotic cells; genes; genetic engineering; humans; immunotherapy; mutation; neoplasms; patients; plasmids
- Abstract:
- ... The CRISPR-Cas9 genome-editing system is a part of the adaptive immune system in archaea and bacteria to defend against invasive nucleic acids from phages and plasmids. The single guide RNA (sgRNA) of the system recognizes its target sequence in the genome, and the Cas9 nuclease of the system acts as a pair of scissors to cleave the double strands of DNA. Since its discovery, CRISPR-Cas9 has becom ...
- DOI:
- 10.1016/j.jconrel.2017.09.012
- PubMed:
- 28911805
- PubMed Central:
- PMC5723556
- https://doi.org/10.1016/j.jconrel.2017.09.012
- Author:
- Z.U. REHMAN; S. UMAR; C. MENG; Z. ULLAH; F. RIAZ; S.U. REHMAN; C. DING
- Source:
- World's poultry science journal 2017 v.73 no.3 pp. 581-590
- ISSN:
- 1743-4777
- Subject:
- adaptive immunity; bacteria; chickens; dendritic cells; fungi; immune response; innate immunity; parasites; pathogens; vaccination; vaccine development; viruses
- Abstract:
- ... Dendritic cells (DCs) are antigen-presenting cells (APCs) with the unique ability to induce both innate immune responses and a highly specific acquired immunity. DCs are crucial to induce immunity, and their maturation and functions are influenced by microbial and environmental stimuli. Chicken DCs are composed of several subtypes including bursal secretory dendritic cells (BSDCs), follicular dend ...
- DOI:
- 10.1017/S0043933917000496
- https://doi.org/10.1017/S0043933917000496
- Author:
- Piotr Orlowski; Maja Pardecka; Joanna Cymerys; Malgorzata Krzyzowska
- Source:
- Microbial pathogenesis 2017 v.109 pp. 99-109
- ISSN:
- 0882-4010
- Subject:
- Ectromelia virus; adaptive immunity; apoptosis; bone marrow; dendritic cells; immunosuppression; innate immunity; mice; mitochondria; pathogenesis; viruses
- Abstract:
- ... Dendritic cells (DCs) are effector cells linking the innate immune system with the adaptive immune response. Many viruses eliminate DCs to prevent host response, induce immunosuppression and to maintain chronic infection. In this study, we examined apoptotic response of dendritic cells during in vitro and in vivo infection with ectromelia virus (ECTV), the causative agent of mousepox. ECTV-infecte ...
- DOI:
- 10.1016/j.micpath.2017.05.037
- https://doi.org/10.1016/j.micpath.2017.05.037
- Author:
- Rosario Castro; Sofie Navelsaker; Aleksei Krasnov; Louis Du Pasquier; Pierre Boudinot
- Source:
- Developmental and comparative immunology 2017 v.75 pp. 28-37
- ISSN:
- 0145-305X
- Subject:
- adaptive immunity; complementary DNA; developmental stages; evolution; fish; frogs; high-throughput nucleotide sequencing; invertebrates; loci; metamorphosis; multigene family; new species; pathogens; receptors; silver; vaccination; vaccines
- Abstract:
- ... During the last decades, gene and cDNA cloning identified TCR and Ig genes across vertebrates; genome sequencing of TCR and Ig loci in many species revealed the different organizations selected during evolution under the pressure of generating diverse repertoires of Ag receptors. By detecting clonotypes over a wide range of frequency, deep sequencing of Ig and TCR transcripts provides a new way to ...
- DOI:
- 10.1016/j.dci.2017.02.018
- https://doi.org/10.1016/j.dci.2017.02.018
- Author:
- Jae Wook Jung; Jung Seok Lee; Young Rim Kim; Se Pyeong Im; Si Won Kim; Jassy Mary S. Lazarte; Jaesung Kim; Kim D. Thompson; Jong Pyo Suh; Tae Sung Jung
- Source:
- Fish & shellfish immunology 2017 v.65 pp. 179-185
- ISSN:
- 1050-4648
- Subject:
- Paralichthys olivaceus; T-lymphocytes; Viral hemorrhagic septicemia virus; Western blotting; adaptive immunity; antigens; binding sites; chemical elements; confocal microscopy; flounder; flow cytometry; immune response; liver; lymphocyte count; monoclonal antibodies; polyacrylamide gel electrophoresis; recombinant proteins; reverse transcriptase polymerase chain reaction; spleen; yeasts
- Abstract:
- ... The T cell receptor (TCR) is the binding site of antigen and is responsible for specifically activating the adaptive immune response. CD3, an essential component of the CD3-TCR complex, is known to be composed of γδ and ε chains in teleost. However, there are few monoclonal antibodies (mAb) available to identify these molecules on T cells, so we aimed to produce a mAb against CD3ε to improve our u ...
- DOI:
- 10.1016/j.fsi.2017.04.016
- https://doi.org/10.1016/j.fsi.2017.04.016
- Author:
- J.M.B. Prieto; M.J.B. Felippe
- Source:
- Comparative immunology, microbiology, and infectious diseases 2017 v.54 pp. 38-44
- ISSN:
- 0147-9571
- Subject:
- B-lymphocytes; Primates; adaptive immunity; autoimmune diseases; cattle; functional properties; guinea pigs; homeostasis; horses; humans; immunoglobulin M; innate immunity; mice; phenotype; rabbits; secretion; swine; tissue distribution
- Abstract:
- ... Three populations of B cells develop in fetal life: B1, B2 and marginal zone B cells. B1 cells play important roles in innate immunity in contrast to B2 cells that perform the conventional roles in adaptive immunity. B1 cells were first identified in mice based on their expression of CD5 and spontaneous secretion of IgM. B1 cells were subsequently found to have unique developmental, phenotype, tis ...
- DOI:
- 10.1016/j.cimid.2017.08.002
- https://doi.org/10.1016/j.cimid.2017.08.002
- Author:
- Xiaocheng Li; Peng Zhang; Xiaosong Jiang; Huarui Du; Chaowu Yang; Zengrong Zhang; Shuai Men; Zhikun Zhang; Wei Jiang; Hongning Wang
- Source:
- Veterinary immunology and immunopathology 2017 v.189 pp. 28-35
- ISSN:
- 0165-2427
- Subject:
- Salmonella Enteritidis; Toll-like receptor 4; adaptive immunity; bacteria; breeds; chickens; death; financial economics; foodborne illness; gene expression; genes; interleukin-8; messenger RNA; methylation; signal transduction
- Abstract:
- ... Salmonella enterica serovar (S. enteritidis) is a pathogenic bacterium that can cause symptoms of food poisoning, leading to death of poultry, resulting in serious economic losses. The MyD88 and TRIF signalling pathways play important roles in activating innate and adaptive immunity in chickens infected with S. enteritidis. The objective of the present study was to characterize in vivo mRNA expres ...
- DOI:
- 10.1016/j.vetimm.2017.05.003
- https://doi.org/10.1016/j.vetimm.2017.05.003
- Author:
- Subhash Verma; Aneesh Thakur; Shailja Katoch; Chander Shekhar; Aasim Habib Wani; Sandeep Kumar; Shweta Dohroo; Geetanjali Singh; Mandeep Sharma
- Source:
- Veterinary immunology and immunopathology 2017 v.192 pp. 20-27
- ISSN:
- 0165-2427
- Subject:
- Jersey; adaptive immunity; breed differences; breeding; cattle; immune response; milk production; India
- Abstract:
- ... Cattle are an integral part of the largely agrarian economy of India. Indigenous breeds of cattle comprise about 80% of total cattle population of the country and contribute significantly to the overall milk production. There are 40 recognized indigenous breeds of cattle and a number of uncharacterized non-descript cattle. Pahari cattle of Himachal Pradesh in Northern India are one such non-descri ...
- DOI:
- 10.1016/j.vetimm.2017.09.003
- https://doi.org/10.1016/j.vetimm.2017.09.003
- Author:
- Ka Lung Cheung; Fan Zhang; Anbalagan Jaganathan; Rajal Sharma; Qiang Zhang; Tsuyoshi Konuma; Tong Shen; June-Yong Lee; Chunyan Ren; Chih-Hung Chen; Geming Lu; Matthew R. Olson; Weijia Zhang; Mark H. Kaplan; Dan R. Littman; Martin J. Walsh; Huabao Xiong; Lei Zeng; Ming-Ming Zhou
- Source:
- Molecular cell 2017 v.65 no.6 pp. 1068-1080.e5
- ISSN:
- 1097-2765
- Subject:
- CD4-positive T-lymphocytes; DNA-directed RNA polymerase; adaptive immunity; cell differentiation; chromatin; cyclins; drugs; genes; mice; phosphorylation; transcription (genetics); transcription factors; transcriptional activation
- Abstract:
- ... The BET proteins are major transcriptional regulators and have emerged as new drug targets, but their functional distinction has remained elusive. In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T helper 17 (Th17) cell differentiation. Brd2 is associated with the chromatin insulator CTCF ...
- DOI:
- 10.1016/j.molcel.2016.12.022
- PubMed:
- 28262505
- PubMed Central:
- PMC5357147
- https://doi.org/10.1016/j.molcel.2016.12.022
- Author:
- Eugene V Koonin; Kira S Makarova; Feng Zhang
- Source:
- Current opinion in microbiology 2017 v.37 pp. 67-78
- ISSN:
- 1369-5274
- Subject:
- RNA; adaptive immunity; evolution; genome; interspersed repetitive sequences; loci
- Abstract:
- ... The bacterial and archaeal CRISPR-Cas systems of adaptive immunity show remarkable diversity of protein composition, effector complex structure, genome locus architecture and mechanisms of adaptation, pre-CRISPR (cr)RNA processing and interference. The CRISPR-Cas systems belong to two classes, with multi-subunit effector complexes in Class 1 and single-protein effector modules in Class 2. Concerte ...
- DOI:
- 10.1016/j.mib.2017.05.008
- PubMed:
- 28605718
- PubMed Central:
- PMC5776717
- https://doi.org/10.1016/j.mib.2017.05.008
- Author:
- Rebecca Devlin; Catarina A. Marques; Richard McCulloch
- Source:
- Current genetics 2017 v.63 no.3 pp. 441-449
- ISSN:
- 0172-8083
- Subject:
- DNA replication; adaptive immunity; antigenic variation; gene conversion; genes; glycoproteins; homologous recombination; immune evasion; models; pathogens; telomeres; transcription (genetics)
- Abstract:
- ... All pathogens must survive host immune attack and, amongst the survival strategies that have evolved, antigenic variation is a particularly widespread reaction to thwart adaptive immunity. Though the reactions that underlie antigenic variation are highly varied, recombination by gene conversion is a widespread approach to immune survival in bacterial and eukaryotic pathogens. In the African trypan ...
- DOI:
- 10.1007/s00294-016-0662-7
- PubMed:
- 27822899
- PubMed Central:
- PMC5422504
- https://doi.org/10.1007/s00294-016-0662-7
- Author:
- Nicola Vitulo; Luisa Dalla Valle; Tatjana Skobo; Giorgio Valle; Lorenzo Alibardi
- Source:
- Protoplasma 2017 v.254 no.6 pp. 2127-2141
- ISSN:
- 0033-183X
- Subject:
- adaptive immunity; amputation; evolution; extracellular matrix; gene expression regulation; genes; histology; immunoglobulins; inflammation; lizards; medicine; metabolism; muscle development; muscle protein; muscles; non-coding RNA; receptors; tail; transcriptome
- Abstract:
- ... Amputated tails of lizards regenerate while limbs form scars which histological structure is very different from the original organs. Lizards provide useful information for regenerative medicine and some hypotheses on the loss of regeneration in terrestrial vertebrates. Analysis of tail and limb transcriptomes shows strong downregulation in the tail blastema for immunoglobulins and surface B and T ...
- DOI:
- 10.1007/s00709-017-1107-y
- https://doi.org/10.1007/s00709-017-1107-y
- Author:
- Cara West; Neal Silverman
- Source:
- Cell 2017 v.169 pp. 188-190
- ISSN:
- 0092-8674
- Subject:
- Diptera; RNA interference; adaptive immunity; exosomes; innate immunity; mammals; models
- Abstract:
- ... For decades, flies have been a model for innate immunity. In this issue of Cell, Tassetto et al. describe a mechanism for antiviral RNAi spreading that parallels mammalian adaptive immunity through reverse-transcribed vDNA circles and the systemic dissemination of small-RNA-containing exosomes. ...
- DOI:
- 10.1016/j.cell.2017.03.032
- https://doi.org/10.1016/j.cell.2017.03.032
- Author:
- Qiuyue Zhang; An Ding; Qianwen Yue; Weiming Li; Yao Zu; Qinghua Zhang
- Source:
- Aquaculture and fisheries 2017 v.2 no.6 pp. 269-277
- ISSN:
- 2096-1758
- Subject:
- Danio rerio; Vibrio parahaemolyticus; adaptive immunity; blood circulation; caudal vein; chemotaxis; eyes; fish; genetic recombination; heart; host-pathogen relationships; hosts; injection site; larvae; lethal dose 50; models; neutrophils; pathogens; phagocytosis; red fluorescent protein; vibriosis; zoonoses
- Abstract:
- ... Vibrio parahaemolyticus (Vp) is an aquatic zoonotic pathogen that causes vibriosis in marine animals as well as sepsis, gastroenteritis and wound infection in human. In vertebrates, the innate immune system plays a critical defense mechanism against Vp infection including transmigration of neutrophils. In this study, we have examined the genetic recombination and infectious process of Vp in the ze ...
- DOI:
- 10.1016/j.aaf.2017.10.006
- https://doi.org/10.1016/j.aaf.2017.10.006
- Author:
- MOHAMMAD HEIDARI; DAN WANG; SHUHONG SUN
- Source:
- Viral Immunology 2017 v.30 no.3 pp. 167-177
- ISSN:
- 1557-8976
- Subject:
- CD4-positive T-lymphocytes; Mardivirus; Marek disease; adaptive immunity; animal organs; antigens; cecum; chickens; disease resistance; duodenum; epithelium; gene expression; gene expression regulation; genes; immune response; immunohistochemistry; innate immunity; macrophages; peripheral nerves; tonsils; vaccination; vaccines; virulent strains; viruses
- Abstract:
- ... Marek’s disease virus (MDV), a highly cell-associated lymphotropic 'alpha-herpesvirus, is the causative agent of Marek’s disease (MD) in domestic chickens. MDV replicates in chicken lymphocytes and establishes a latent infection within CD4+ T cells. The latently infected CD4+ T cells carry the virus to visceral organs, peripheral nerves, and feather follicle epithelium (FFE). Although MD vaccines ...
- Handle:
- 10113/5700714
- DOI:
- 10.1089/vim.2016.0126
- https://doi.org/10.1089/vim.2016.0126
75. Early exposure to Batrachochytrium dendrobatidis causes profound immunosuppression in amphibians
- Author:
- Andrés Fernández-Loras; Saioa Fernández-Beaskoetxea; Elena Arriero; Matthew C. Fisher; Jaime Bosch
- Source:
- European journal of wildlife research 2017 v.63 no.6 pp. 99
- ISSN:
- 1612-4642
- Subject:
- Batrachochytrium dendrobatidis; adaptive immunity; blood serum; fungi; immune response; immunoglobulin M; immunoglobulin Y; immunosuppression; juveniles; lymphocytes; metamorphosis; neutrophils; pathogens; tadpoles; toads
- Abstract:
- ... Fungal pathogens have evolved a broad suite of strategies aiming at evading the host immune response. Amphibians are globally infected by the panzootic chytrid fungus Batrachochytrium dendrobatidis (Bd) and, while robust innate immune defences have been characterised, there is little evidence for the existence of effective adaptive immunity. We determine the immune response of the common midwife t ...
- DOI:
- 10.1007/s10344-017-1161-y
- https://doi.org/10.1007/s10344-017-1161-y
- Author:
- Yali Li; Yuanyuan Wang; Yanping Wu; Baikui Wang; Xi Chen; Xin Xu; Hongliang Chen; Weifen Li; Xiaogang Xu
- Source:
- Developmental and comparative immunology 2017 v.73 pp. 21-26
- ISSN:
- 0145-305X
- Subject:
- Echinacea purpurea; adaptive immunity; chemical elements; dendritic cells; gene expression regulation; interferon-gamma; interleukin-10; interleukin-12; mice; mitogen-activated protein kinase; phagocytosis; phenotype; transcription factor NF-kappa B; transforming growth factor beta 1
- Abstract:
- ... Dendritic cells (DCs) comprise a system of highly professional antigen presenting cells (APCs) which connect innate and adaptive immunity by undergoing dramatic shift in their maturation state. Phytomedicine Echinacea purpurea extracts (EE) could modulate murine dendritic cell fate and function. However, the underlying mechanism of EE on DCs development and maturation remains limited. In this stud ...
- DOI:
- 10.1016/j.dci.2017.03.002
- https://doi.org/10.1016/j.dci.2017.03.002
- Author:
- S. Prims; N. Pintens; H. Vergauwen; S. Van Cruchten; C. Van Ginneken; C. Casteleyn
- Source:
- Veterinary immunology and immunopathology 2017 v.184 pp. 1-7
- ISSN:
- 0165-2427
- Subject:
- adaptive immunity; antigens; artificial rearing; brooders; colostrum; epithelial cells; epithelium; euthanasia; hybrids; ileum; immunohistochemistry; litter size; milk; milk replacer; neonates; oropharynx; palate; piglets; sows; tissue analysis; tonsils
- Abstract:
- ... The high prolificacy of modern hybrid sows has increased the mean litter size during the last decades. However, rearing large litters is challenging and has increased the use of alternative management strategies such as euthanasia of weak piglets, cross-fostering, supplementing piglets with milk, split-nursing and split-weaning. The latter includes artificial rearing on brooders where piglets have ...
- DOI:
- 10.1016/j.vetimm.2016.12.009
- https://doi.org/10.1016/j.vetimm.2016.12.009
- Author:
- Valentin P. Shichkin; Oleksandr I. Gorbach; Olga A. Zuieva; Nataliia I. Grabchenko; Irina A. Aksyonova; Boris M. Todurov
- Source:
- Cryobiology 2017 v.78 pp. 70-79
- ISSN:
- 0011-2240
- Subject:
- T-lymphocytes; adaptive immunity; autografting; cell suspension culture; cryopreservation; cryoprotectants; epithelial cells; freeze-thaw cycles; glycerol; heart diseases; humans; neonates; patients; starch; storage; sucrose; thymus gland; viability
- Abstract:
- ... The thymus is the major site of T lymphocyte generation and so is critical for a functional adaptive immune system. Since, thymectomy is a component of neonatal surgery for congenital heart diseases, it provides great potential for collection and storage of thymic tissue for autologous transplantation. However, specific investigation into the optimum parameters for thymic tissue cryopreservation h ...
- DOI:
- 10.1016/j.cryobiol.2017.06.010
- https://doi.org/10.1016/j.cryobiol.2017.06.010
79. Effect of porcine circovirus type 2 (PCV2) on the function of splenic CD11c+ dendritic cells in mice
- Author:
- Xiaobo Wang; Ligong Chen; Wanzhe Yuan; Yanqin Li; Limin Li; Tanqing Li; Huanrong Li; Qinye Song
- Source:
- Archives of virology 2017 v.162 no.5 pp. 1289-1298
- ISSN:
- 0304-8608
- Subject:
- CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Porcine circovirus-2; adaptive immunity; chemical elements; chronic diseases; dendritic cells; endocytosis; enzyme-linked immunosorbent assay; flow cytometry; immune response; immunomodulators; interferon-alpha; interferon-gamma; interleukin-12; interleukin-4; mice; secretion; spleen; swine; tumor necrosis factor-alpha; viruses
- Abstract:
- ... Porcine circovirus-associated disease (PCVAD) caused by porcine circovirus type 2 (PCV2) is an important disease in the global pig industry. Dendritic cells (DCs) are the primary immune cells capable of initiating adaptive immune responses as well as major target cells of PCV2. To determine whether PCV2 affects the immune functions of DCs, we evaluated the expression of endocytosis and co-stimulat ...
- DOI:
- 10.1007/s00705-017-3221-8
- https://doi.org/10.1007/s00705-017-3221-8
- Author:
- P.R.B. Silva; C.D. Nelson; J.P. Driver; W.W. Thatcher; R.C. Chebel
- Source:
- Journal of dairy science 2017 v.100 no.10 pp. 8471-8483
- ISSN:
- 0022-0302
- Subject:
- absorbance; adaptive immunity; blood serum; calving; dairy cows; energy metabolism; fluorescence; gene expression; genes; geometry; granulocytes; haptoglobins; immune response; immunoglobulin G; insulin-like growth factor I; intracellular signaling peptides and proteins; messenger RNA; ovalbumin; phagocytosis; pregnancy; somatotropin; tumor necrosis factor-alpha
- Abstract:
- ... Objectives of the current experiment were to evaluate the effects of treatment of periparturient dairy cows with recombinant bovine somatotropin (rbST) on mRNA expression in peripheral leukocytes for genes related to the somatotropic axis, cell energy metabolism, and innate and adaptive immune responses. Cows were enrolled in the experiment at 253 ± 3 d of gestation and assigned to an untreated co ...
- DOI:
- 10.3168/jds.2016-12106
- https://doi.org/10.3168/jds.2016-12106
81. Effectiveness of Germination on Protein Hydrolysis as a Way To Reduce Adverse Reactions to Wheat
- Author:
- Boukid Fatma; Prandi Barbara; Buhler Sofie; Sforza Stefano
- Source:
- Journal of agricultural and food chemistry 2017 v.65 no.45 pp. 9854-9860
- ISSN:
- 1520-5118
- Subject:
- adaptive immunity; adverse effects; asthma; celiac disease; foods; genotype; germination; gluten; hydrolysis; in vitro digestion; inflammation; ingredients; innate immunity; lipids; peptides; polyacrylamide gel electrophoresis; protein composition; protein degradation; starch; statistical analysis; wheat; wheat protein
- Abstract:
- ... In this work, the aim is to study the effectiveness of germination on wheat protein degradation, with a specific focus on proteins involved in adverse reactions to wheat. The effects of 8 days of germination at 25 °C on the chemical composition and the protein profile were determined. Germination did not have a significant effect on starch, protein, lipid, and ash contents. General protein profile ...
- DOI:
- 10.1021/acs.jafc.7b03175
- https://doi.org/10.1021/acs.jafc.7b03175
- Author:
- Hai Trong Nguyen; Thuy Thi Thu Nguyen; Yi-Ting Wang; Pei-Chyi Wang; Shih-Chu Chen
- Source:
- Fish & shellfish immunology 2017 v.68 pp. 124-131
- ISSN:
- 1050-4648
- Subject:
- Epinephelus coioides; Toll-like receptor 9; Vibrio harveyi; adaptive immunity; adjuvants; antibodies; grouper; immune response; immunization; major histocompatibility complex; messenger RNA; oligodeoxyribonucleotides; pathogens; plasmids; spleen; tumor necrosis factor-alpha; vaccines; vibriosis
- Abstract:
- ... Vibrio harveyi is a major bacterial pathogen that causes serious vibriosis in cultured groupers, leading to massive deaths. In this study, we evaluated the immune responses and protective efficacy of vaccines containing V. harveyi formalin-killed cells (FKC) formulated with CpG ODN 1668-enriched plasmids (p30CpG and p60CpG) in the orange-spotted grouper. Results indicated that antibody titres were ...
- DOI:
- 10.1016/j.fsi.2017.07.018
- https://doi.org/10.1016/j.fsi.2017.07.018
- Author:
- Xing-yu Gu; Xu Chu; Xiao-Li Zeng; Hai-Rong Bao; Xiao-Ju Liu
- Source:
- Environmental pollution 2017 pp. -
- ISSN:
- 0269-7491
- Subject:
- T-lymphocytes; Western blotting; adaptive immunity; aerosols; animal models; blood serum; breathing; cigarettes; density gradient centrifugation; enzyme-linked immunosorbent assay; flow cytometry; interferon-gamma; interleukin-10; interleukin-17; interleukin-4; intraperitoneal injection; messenger RNA; mice; particulates; proteins; respiratory tract diseases; reverse transcriptase polymerase chain reaction; signal transduction
- Abstract:
- ... Chronic Obstructive Pulmonary Disease (COPD) is associated with T lymphocytes subset (Th1/Th2, Th17/Treg) imbalance. Notch signaling pathway plays a key role in the development of the adaptive immunity. The immune disorder induced by fine particulate matter (PM2.5) is related to COPD. The aim of this study was to investigate the mechanism by which PM2.5 influences the Notch signaling pathway leadi ...
- DOI:
- 10.1016/j.envpol.2017.03.070
- https://doi.org/10.1016/j.envpol.2017.03.070
- Author:
- Saekil Yun; Jin Woo Jun; Sib Sankar Giri; Hyoun Joong Kim; Cheng Chi; Sang Geun Kim; Sang Wha Kim; Se Chang Park
- Source:
- Vaccine 2017 v.35 no.32 pp. 3959-3965
- ISSN:
- 0264-410X
- Subject:
- Aeromonas hydrophila; Cobitidae; Cyprinus carpio; adaptive immunity; agglutination; antibodies; antigens; aquaculture; blood; carp; disease prevention; gene expression; gene expression regulation; genes; immunoglobulin M; interleukin-10; interleukin-1beta; kidneys; lysozyme; messenger RNA; scanning electron microscopy; survival rate; transforming growth factor beta; tumor necrosis factor-alpha; vaccination; vaccines
- Abstract:
- ... Control and prevention of disease is a high priority in aquaculture, and vaccination is important to prevent outbreaks. Here, poly(d,l-lactide-co-glycolic acid) (PLGA) microparticles (MPs) approximately 36μm in diameter were used to encapsulate and deliver Aeromonas hydrophila formalin-killed cells (FKC) as an antigen, and the innate and adaptive immune responses of cyprinid loaches and common car ...
- DOI:
- 10.1016/j.vaccine.2017.06.005
- https://doi.org/10.1016/j.vaccine.2017.06.005
- Author:
- Samah R. Khalil; Rasha M. Reda; Ashraf Awad
- Source:
- Fish & shellfish immunology 2017 v.67 pp. 119-128
- ISSN:
- 1050-4648
- Subject:
- atrazine; immunoglobulin M; Cyprinus carpio; Arthrospira platensis; genes; dietary supplements; aquaculture; adaptive immunity; carp; gene expression; spleen; disease resistance; interleukin-10; gene expression regulation; messenger RNA; feed additives; transcription (genetics); subchronic exposure; Aeromonas sobria; immune response; kidneys; antibacterial properties; lysozyme; quantitative polymerase chain reaction; viability; survival rate; complement; inflammation
- Abstract:
- ... The present study evaluated the immunotoxicological effects of the herbicide atrazine (ATZ) at sub-lethal concentrations and the potential ameliorative influence of Spirulina platensis (SP) over a sub-chronic exposure period on Cyprinus carpio L., also known as common carp. Common carp was sampled after a 40-days exposure to ATZ (428 μg/L) and SP (1%), individually or in combination to assess the ...
- DOI:
- 10.1016/j.fsi.2017.05.065
- https://doi.org/10.1016/j.fsi.2017.05.065
- Author:
- Simon Vitt; Anna K. Rahn; Lisa Drolshagen; Theo C. M. Bakker; Jörn P. Scharsack; Ingolf P. Rick
- Source:
- Aquatic ecology 2017 v.51 no.4 pp. 499-509
- ISSN:
- 1386-2588
- Subject:
- Gasterosteus aculeatus; adaptive immunity; aquatic ecosystems; body condition; chronic exposure; fish; immune response; solar radiation; ultraviolet radiation
- Abstract:
- ... With ongoing environmental change, ultraviolet-B radiation (UVB) reaching the Earth’s surface has increased over recent decades with consequences for terrestrial and also aquatic ecosystems. Despite evidence for direct physiological and immunological responses of aquatic animals following enhanced UVB exposure, studies investigating indirect impacts of ambient UVB radiation are scarce and mainly u ...
- DOI:
- 10.1007/s10452-017-9632-5
- https://doi.org/10.1007/s10452-017-9632-5
- Author:
- Na Feng; Zhizhao Zhou; Yuanxia Li; Lifang Zhao; Zhengfeng Xue; Rong Lu; Kunpeng Jia
- Source:
- Virus research 2017 v.237 pp. 27-36
- ISSN:
- 0168-1702
- Subject:
- Enterovirus; adaptive immunity; etiological agents; hand, foot and mouth disease; immune system; interferons; interleukin-1; monitoring; public health; viruses
- Abstract:
- ... Enterovirus71(EV71), the etiological agent of hand-foot-and-mouth disease, has increasingly become a public health challenge around the world. Type I interferons (IFNs) are an important family of cytokines that regulate innate and adaptive immune responses to pathogens.These pathways are tightly regulated by the host to prevent an inappropriate cellular response, but viruses can modulate these pat ...
- DOI:
- 10.1016/j.virusres.2017.05.008
- https://doi.org/10.1016/j.virusres.2017.05.008
88. Evaluation of the immunocrit method to detect failure of passively acquired immunity in dairy calves
- Author:
- Kimberly A. Thompson; Marie C. Rayburn; Munashe Chigerwe
- Source:
- Journal of the American Veterinary Medical Association 2017 v.251 no.6 pp. 702-705
- ISSN:
- 0003-1488
- Subject:
- adaptive immunity; ammonium sulfate; blood sampling; blood serum; confidence interval; dairy calves; females; graphs; immunoglobulin G; reference standards
- Abstract:
- ... OBJECTIVE To evaluate the usefulness of serum immunocrit measurement to detect failure of passively acquired immunity (FPI) in dairy calves. DESIGN Diagnostic test evaluation. ANIMALS 249 female dairy calves (age, 2 to 6 days). PROCEDURES A blood sample was collected from each calf, and serum was harvested. Immunocrit was measured in serum samples by use of 55% ammonium sulfate solution and the st ...
- DOI:
- 10.2460/javma.251.6.702
- https://doi.org/10.2460/javma.251.6.702
- Author:
- Joseph A. Westrich; Cody J. Warren; Dohun Pyeon
- Source:
- Virus research 2017 v.231 pp. 21-33
- ISSN:
- 0168-1702
- Subject:
- Papillomaviridae; adaptive immunity; disease course; gene expression; genome; humans; immune response; immunomodulators; keratinocytes; medical treatment; neoplasms; oncogene proteins; post-translational modification; protein-protein interactions; sequence diversity; viruses
- Abstract:
- ... A majority of human papillomavirus (HPV) infections are asymptomatic and self-resolving in the absence of medical interventions. Various innate and adaptive immune responses, as well as physical barriers, have been implicated in controlling early HPV infections. However, if HPV overcomes these host immune defenses and establishes persistence in basal keratinocytes, it becomes very difficult for th ...
- DOI:
- 10.1016/j.virusres.2016.11.023
- PubMed:
- 27890631
- PubMed Central:
- PMC5325784
- https://doi.org/10.1016/j.virusres.2016.11.023
- Author:
- Ruisong Pei; Derek A. Martin; Diana M. DiMarco; Bradley W. Bolling
- Source:
- Critical reviews in food science and nutrition 2017 v.57 no.8 pp. 1569-1583
- ISSN:
- 1549-7852
- Subject:
- absorption barrier; adaptive immunity; adipose tissue; appetite; chronic diseases; constipation; cytokines; developing countries; diabetes; diarrhea; diet; endotoxins; exercise; gastrointestinal system; hypertension; inflammation; lactose intolerance; lipid composition; microorganisms; neoplasms; obesity; pathogens; risk; yogurt
- Abstract:
- ... Obesity is associated with increased risk for chronic diseases, and affects both developed and developing nations. Yogurt is a nutrient-dense food that may benefit individuals with lactose intolerance, constipation and diarrheal diseases, hypertension, cardiovascular diseases, diabetes, and certain types of cancer. Emerging evidence suggests that yogurt consumption might also improve the health of ...
- DOI:
- 10.1080/10408398.2014.883356
- https://doi.org/10.1080/10408398.2014.883356
- Author:
- L. Råberg; Å. Hagström; M. Andersson; S. Bartkova; K. Scherman; M. Strandh; B. Tschirren
- Source:
- Journal of evolutionary biology 2017 v.30 no.5 pp. 1034-1041
- ISSN:
- 1010-061X
- Subject:
- Borrelia afzelii; adaptive immunity; antigenic variation; bacteria; coevolution; correlation; hosts; quantitative polymerase chain reaction; rodents; shrews; surface proteins; ticks
- Abstract:
- ... Antigenic diversity in pathogenic microbes can be a result of at least three different processes: diversifying selection by acquired immunity, host–pathogen coevolution and/or host specialization. Here, we investigate whether host specialization drives diversity at ospC (which encodes an immunodominant surface protein) in the tick‐transmitted bacterium Borrelia afzelii. We determined prevalence an ...
- DOI:
- 10.1111/jeb.13075
- https://doi.org/10.1111/jeb.13075
- Author:
- S. Picchietti; N. Nuñez-Ortiz; V. Stocchi; E. Randelli; F. Buonocore; L. Guerra; G. Scapigliati
- Source:
- Fish & shellfish immunology 2017 v.63 pp. 40-52
- ISSN:
- 1050-4648
- Subject:
- Dicentrarchus labrax; Oncorhynchus mykiss; Western blotting; adaptive immunity; antigens; antiserum; bass; blood serum; complementary DNA; enzyme-linked immunosorbent assay; evolution; flow cytometry; fluorescent antibody technique; genes; gills; immunization; immunoglobulin M; immunoglobulin T; immunohistochemistry; in situ hybridization; intestines; kidneys; lymphocytes; messenger RNA; mucus; nucleotide sequences; oligonucleotides; polyclonal antibodies; polypeptides; rabbits; reverse transcriptase polymerase chain reaction; spleen; synthetic peptides; tissues
- Abstract:
- ... Immunoglobulin T (IgT) is one of the key effector molecules of jawed vertebrate's adaptive immune system, and in this work we describe the quantitative distribution of IgT-expressing and IgT-producing cells in tissues of the European seabass Dicentrarchus labrax by using mRNA riboprobes and a specific anti-IgT antibody.A polyclonal antiserum (pAb) was prepared by immunizing rabbits with three synt ...
- DOI:
- 10.1016/j.fsi.2017.02.002
- https://doi.org/10.1016/j.fsi.2017.02.002
- Author:
- Felipe Augusto Cerni; Manuela Berto Pucca; Karina Furlani Zoccal; Fabiani Gai Frantz; Lucia Helena Faccioli; Eliane Candiani Arantes
- Source:
- Toxicon 2017 v.134 pp. 18-25
- ISSN:
- 0041-0101
- Subject:
- Tityus serrulatus; adaptive immunity; alanine transaminase; beta-globulins; bioactive properties; blood serum; gamma-globulins; inflammation; innate immunity; interleukin-17; interleukin-6; mice; monocytes; neutrophils; nitric oxide; toxins; tumor necrosis factor-alpha; urea; venoms
- Abstract:
- ... Tityus serrulatus (Ts) venom is composed of a mixture of toxins presenting diverse biological functions. However, although this venom has been studied over the past three decades, omics analysis revealed that most of its toxins are not identified or their biological activities are unknown. Ts19 Frag-II is included in this group, which function is still uncertain. This study aimed to expand the bio ...
- DOI:
- 10.1016/j.toxicon.2017.05.013
- https://doi.org/10.1016/j.toxicon.2017.05.013
- Author:
- Yingying Zhang; Mengying Zhang; Xueqin Li; Zongsheng Tang; Ling He; Kun Lv
- Source:
- Molecular Immunology 2017 pp. -
- ISSN:
- 0161-5890
- Subject:
- CD4-positive T-lymphocytes; adaptive immunity; arginine; cell proliferation; heart; inducible nitric oxide synthase; interferon-gamma; interleukin-4; mice; myocarditis; suppressor cells
- Abstract:
- ... Galectin-9 is known to play a role in the modulation of innate and adaptive immunity to ameliorate CVB3-induced myocarditis. In the present study, we found that galectin-9 induced the expansion of CD11b+Ly-6C+ myeloid-derived suppressor cells (MDSCs) in the heart from CVB3-infected mice. Adoptive transfer of CD11b+Ly-6C+ MDSCs significantly alleviated myocarditis accompanied by increased Th2 and T ...
- DOI:
- 10.1016/j.molimm.2017.01.013
- https://doi.org/10.1016/j.molimm.2017.01.013
- Author:
- DJ Middleton; S Riddell; R Klein; R Arkinstall; J Haining; L Frazer; C Mottley; R Evans; D Johnson; J Pallister
- Source:
- Australian veterinary journal 2017 v.95 no.1-2 pp. 10-18
- ISSN:
- 0005-0423
- Subject:
- nose; urine; tonsils; ferrets; genes; blood; virus replication; risk; infectious diseases; adaptive immunity; mouth; spleen; viruses; people; lymph nodes; central nervous system; acute course; dogs; pathogenicity; neutralizing antibodies; kidneys; Hendra henipavirus; neutralization; dog diseases; Beagle; horses; Australia
- Abstract:
- ... OBJECTIVE: Characterisation of experimental Hendra virus (HeV) infection in dogs and assessment of associated transmission risk. METHODS: Beagle dogs were exposed oronasally to Hendra virus/Australia/Horse/2008/Redlands or to blood collected from HeV‐infected ferrets. Ferrets were exposed to oral fluids collected from dogs after canine exposure to HeV. Observations made and samples tested post‐exp ...
- DOI:
- 10.1111/avj.12552
- https://doi.org/10.1111/avj.12552
- Author:
- Hotcherl Jeong; Baik Lin Seong
- Source:
- journal of microbiology 2017 v.55 no.3 pp. 220-230
- ISSN:
- 1225-8873
- Subject:
- adaptive immunity; antigen-presenting cells; bioprocessing; cell culture; cost effectiveness; humans; livestock; public health; vaccination; vaccines; viral proteins; virus-like particles; viruses
- Abstract:
- ... Emerging viruses pose a major threat to humans and livestock with global public health and economic burdens. Vaccination remains an effective tool to reduce this threat, and yet, the conventional cell culture often fails to produce sufficient vaccine dose. As an alternative to cell-culture based vaccine, virus-like particles (VLPs) are considered as a highpriority vaccine strategy against emerging ...
- DOI:
- 10.1007/s12275-017-7058-3
- PubMed:
- 28243941
- PubMed Central:
- PMC7090582
- https://doi.org/10.1007/s12275-017-7058-3
- Author:
- Vijai Singh; Darren Braddick; Pawan Kumar Dhar
- Source:
- Gene 2017 v.599 pp. 1-18
- ISSN:
- 0378-1119
- Subject:
- Archaea; DNA repair; adaptive immunity; bacteria; genome; image analysis; loci; plasmids; viruses
- Abstract:
- ... CRISPR-Cas9 is an RNA-mediated adaptive immune system that protects bacteria and archaea from viruses or plasmids. Herein we discuss the recent development of CRISPR-Cas9 into a key technology for genome editing, targeting, and regulation in a wide range of organisms and cell types. It requires a custom designed single guide-RNA (sgRNA), a Cas9 endonuclease, and PAM sequences in the target region. ...
- DOI:
- 10.1016/j.gene.2016.11.008
- https://doi.org/10.1016/j.gene.2016.11.008
- Author:
- De-Hai Xu; Gabriel S.A. Moreira; Craig A. Shoemaker; Dunhua Zhang; Benjamin H. Beck
- Source:
- Fish & shellfish immunology 2017 v.66 no. pp. 540-547
- ISSN:
- 1050-4648
- Subject:
- Ichthyophthirius multifiliis; Ictalurus punctatus; Toll-like receptors; adaptive immunity; antibodies; cytokines; freshwater fish; gene expression; gene expression regulation; genes; gills; immune response; immunoglobulin M; interferon-gamma; intestines; liver; spleen; vaccination
- Abstract:
- ... Ichthyophthiriasis caused by Ichthyophthirius multifiliis (Ich) has a worldwide distribution and affects most freshwater fishes. Fish surviving natural infection and/or immunized with Ich develop strong innate and adaptive immune responses. However, there is a lack of the knowledge regarding immune gene expression patterns in systemic and mucosal immune tissues, and how immune genes interact and l ...
- DOI:
- 10.1016/j.fsi.2017.05.051
- CHORUS:
- 10.1016/j.fsi.2017.05.051
- Chorus Open Access:
- 10.1016/j.fsi.2017.05.051
- https://doi.org/10.1016/j.fsi.2017.05.051
- Author:
- Qiang Liu; Yong-Li Zhang; Shou-Ping Hu; Ze-Lin Ma; Su-Li Gao; Bin Sun; Fei Xiao; Zhuo Zhang; Xue-Hui Cai; Xi-Jun He
- Source:
- Veterinary microbiology 2017 v.210 pp. 134-141
- ISSN:
- 0378-1135
- Subject:
- Porcine reproductive and respiratory syndrome virus; adaptive immunity; antigens; cytoplasm; cytotoxic T-lymphocytes; epithelial cells; interferon-gamma; lungs; macrophages; major histocompatibility complex; pathogens; proteasome endopeptidase complex; proteolysis; receptors; swine; therapeutics
- Abstract:
- ... The elimination of infected cells by cytotoxic T lymphocytes (CTLs) occurs through interactions between T cell receptors (TCRs) and pathogen-derived antigenic peptide-major histocompatibility complex (MHC) class I complexes. The immunoproteasome (i-proteasome), which is a large proteolytic machine derived from the constitutive proteasome, is highly efficient at processing antigens for presentation ...
- DOI:
- 10.1016/j.vetmic.2017.07.024
- https://doi.org/10.1016/j.vetmic.2017.07.024
100. Expression pattern of CD11c on lung immune cells after disseminated murine cytomegalovirus infection
- Author:
- Yi Liao; Xinglou Liu; Yuan Huang; Heyu Huang; Yuanyuan Lu; Yanan Zhang; Sainan Shu; Feng Fang
- Source:
- Virology journal 2017 v.14 no.1 pp. 132
- ISSN:
- 1743-422X
- Subject:
- CD8-positive T-lymphocytes; Cytomegalovirus; Muromegalovirus; adaptive immunity; animal models; cell suspension culture; flow cytometry; immune evasion; lipopolysaccharides; lungs; mice; natural killer cells; spleen
- Abstract:
- ... BACKGROUND: Cytomegalovirus (CMV) infection occurs frequently and is widespread globally. Numerous studies have shown that various types of immune cells play roles in mediating the response to CMV infection. CD11c, a commonly used dendritic cell (DC) marker, is expressed by other immune cells as well, such as T cells. This study analyzed the immune cells that express CD11c and monitored the expres ...
- DOI:
- 10.1186/s12985-017-0801-x
- PubMed:
- 28720115
- PubMed Central:
- PMC5516330
- https://doi.org/10.1186/s12985-017-0801-x
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