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- Epand, Richard M., et al. Show all 6 Authors
- Biochemistry 2017 v.56 no.9 pp. 1337-1347
- affinity chromatography; biosynthesis; circular dichroism spectroscopy; diacylglycerol kinase; diacylglycerols; epilepsy; freezing; genes; glycerol; heart diseases; heat; hemolytic uremic syndrome; humans; nickel; phosphorylation; proteins; thawing
- ... Diacylglycerol kinase ε (DGKε) catalyzes the phosphorylation of diacylglycerol, producing phosphatidic acid. DGKε demonstrates exquisite specificity for the acyl chains of diacylglycerol. This contributes to the enrichment of particular acyl chains within the lipids of the phosphatidylinositol cycle. Phosphatidylinositol is highly enriched with 1-stearoyl-2-arachidonoyl, which is important for mai ...