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1. A Fusion Protein of the p53 Transaction Domain and the p53-Binding Domain of the Oncoprotein MdmX as an Efficient System for High-Throughput Screening of MdmX Inhibitors

Author:
Qin, Lingyun,   et al.   ; Chen, Rong; Zhou, Jingjing; Chen, Yao; Huang, Yongqi; Liu, Huili; Su, Zhengding;     Show all 7 Authors
Source:
Biochemistry 2017 v.56 no.25 pp. 3273-3282
ISSN:
1520-4995
Subject:
amino acids; antineoplastic activity; drugs; fluorescence; fluorescence emission spectroscopy; ligands; models; neoplasms; oncogene proteins; screening; therapeutics
Abstract:
... In nearly half of cancers, the anticancer activity of p53 protein is often impaired by the overexpressed oncoprotein Mdm2 and its homologue, MdmX, demanding efficient therapeutics to disrupt the aberrant p53–MdmX/Mdm2 interactions to restore the p53 activity. While many potent Mdm2-specific inhibitors have already undergone clinical investigations, searching for MdmX-specific inhibitors has become ...
DOI:
10.1021/acs.biochem.7b00085