Publication year rev: 7983-2017 / Subject term: lignans / Text availability: Citation in PubAg

1. A New Lignan from Cinnamomum burmanii

Author:: L. T. Yuan; C. L. Kao; C. T. Chen; H. T. Li; C. Y. Chen
Source:: Chemistry of natural compounds 2017 v.53 no.4 pp. 623-625
ISSN:: 0009-3130
Subject:: Cinnamomum; chemistry; lignans; roots; spectroscopy
Abstract:: ... Investigation of the roots extract of Cinnamomum burmanii (Lauraceae) led to the isolation of one new lignan, cinnaburmanin A (1). Its structure was determined through in-depth spectroscopic and mass-spectrometric analyses. ...
DOI:: 10.1007/s10600-017-2074-4
: https://doi.org/10.1007/s10600-017-2074-4

2. A New Neolignan from the Aerial Parts of Prunella vulgaris var. lilacina

Author:: Changyeol Lee; Sang Hee Shim
Source:: Chemistry of natural compounds 2017 v.53 no.1 pp. 24-27
ISSN:: 0009-3130
Subject:: 4-hydroxybenzoic acid; Prunella vulgaris; aerial parts; alcohols; chemistry; flavonoids; lignans; steroids; triterpenoids
Abstract:: ... Prunella vulgaris is known to contain pentacyclic triterpenoids, flavonoids, phenolic compounds, and steroids. Among the triterpenoids, the oleanane-type, ursane-type, and lupane-type triterpenoids have been known to be predominant. Our phytochemical study led to the isolation of a new neolignan, 9′-O-butyl dehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (1), together with four known compounds, ...
DOI:: 10.1007/s10600-017-1902-x
: https://doi.org/10.1007/s10600-017-1902-x

3. A high throughput mass spectrometry screening analysis based on two-dimensional carbon microfiber fractionation system

Author:: Biao Ma; Yilin Zou; Xuan Xie; Jinhua Zhao; Xiangfan Piao; Jingyi Piao; Zhongping Yao; Maurizio Quinto; Gang Wang; Donghao Li
Source:: Journal of chromatography 2017 pp. -
ISSN:: 0021-9673
Subject:: Schisandra chinensis; carbon; carbon fibers; chromatography; flavonoids; fractionation; ionization; lignans; mass spectrometry; models; organic acids and salts; quantitative analysis; screening; solvents; statistical analysis
Abstract:: ... A novel high-throughput, solvent saving and versatile integrated two-dimensional microscale carbon fiber/active carbon fiber system (2DμCFs) that allows a simply and rapid separation of compounds in low-polar, medium-polar and high-polar fractions, has been coupled with ambient ionization-mass spectrometry (ESI-Q-TOF-MS and ESI-QqQ-MS) for screening and quantitative analyses of real samples. 2DμCF ...
DOI:: 10.1016/j.chroma.2017.04.047
: https://doi.org/10.1016/j.chroma.2017.04.047

4. A new lignan and a new terpenoid from Achillea millefolium L

Author:: Jing Liu; Dan Wang; Li He; Qi Mao; Xiaofang Hu
Source:: Phytochemistry letters 2017 v.22 pp. 247-250
ISSN:: 1874-3900
Subject:: Achillea millefolium; lignans; luteolin; methanol; nuclear magnetic resonance spectroscopy; spectral analysis; terpenoids
Abstract:: ... A phytochemical investigation from methanol extract of Achillea millefolium, (Asteraceae) resulted in the isolation of one new lignan, (+)-lyoniresinol 4-O-α-l −arabinofuranoside (1) and one new terpenoid, achiterpenoside A (2), together with four other known compounds, named as Achillinin A (3), (+)-lyoniresinol (4), luteolin (5), camazulene (6). The structures of 1 and 2 were elucidated based on ...
DOI:: 10.1016/j.phytol.2017.10.009
: https://doi.org/10.1016/j.phytol.2017.10.009

5. Absorption, distribution, metabolism, and excretion of [14C]sesamin in rats

Author:: Namino Tomimori; Tomohiro Rogi; Hiroshi Shibata
Source:: Molecular nutrition & food research 2017 v.61 no.8 pp. -
ISSN:: 1613-4125
Subject:: absorption; autoradiography; bile; carbon; cytochrome P-450; excretion; feces; half life; intestinal microorganisms; kidneys; lignans; liver; metabolites; oral administration; pharmacokinetics; radioactivity; radionuclides; rats; sesame seed; tissue distribution; urine
Abstract:: ... SCOPE: Sesamin is a major lignan in sesame seeds and has various physiological effects. Although metabolism of sesamin by cytochrome P450 or intestinal microflora has been reported, little is known concerning the mass balance, pharmacokinetics, and tissue distribution of sesamin. METHODS AND RESULTS: Absorption, distribution, metabolism, and excretion of [¹⁴C]sesamin were investigated after a sing ...
DOI:: 10.1002/mnfr.201600844
: https://doi.org/10.1002/mnfr.201600844

6. Anti-complementary constituents of Anchusa italica

Author:: Yu-zhen Hou; Kui-kui Chen; Xi-ling Deng; Ze-long Fu; Dao-feng Chen; Qi Wang
Source:: Natural product research 2017 v.31 no.21 pp. 2572-2574
ISSN:: 1478-6427
Subject:: Anchusa azurea; alcohols; alkaloids; complement; flavonoids; fractionation; lignans; triterpenoids
Abstract:: ... Activity-guided fractionation for complement inhibitors led to the isolation of 24 known compounds from Anchusa italica . Chemical types include eight megastigmane compounds, five triterpenoid compounds, five lignan compounds, three flavonoid compounds, two alkaloid compounds and one phenthyl alcohol compound. Among which, a lignan (medioresinol), an alkaloid (5-hydroxypyrrolidin-2-one) and a flav ...
DOI:: 10.1080/14786419.2017.1320789
: https://doi.org/10.1080/14786419.2017.1320789

7. Anti-inflammatory neolignans from Epimedium pseudowushanese

Author:: Huihui Ti; Ping Wu; Liangxiong Xu; Xiaoyi Wei
Source:: Natural product research 2017 v.31 no.22 pp. 2621-2628
ISSN:: 1478-6427
Subject:: Epimedium; anti-inflammatory activity; lignans; secretion; spectroscopy; tumor necrosis factor-alpha
Abstract:: ... One new 8- O -4′ neolignan has been isolated from Epimedium pseudowushanese B. L. Guo, together with nine other known neolignans. The structures of these neolignans were elucidated using spectroscopic and chemical techniques, and their anti-inflammatory activities were also evaluated. The results of these experiments revealed that compound 6 was the most potent of the 10 different compounds tested ...
DOI:: 10.1080/14786419.2017.1289200
: https://doi.org/10.1080/14786419.2017.1289200

8. Antibacterial neolignans from the leaves of Melaleuca bracteata

Author:: Can Li; Hongxin Liu; Liyun Zhao; Weimin Zhang; Shengxiang Qiu; Xiaoyun Yang; Haibo Tan
Source:: Fitoterapia 2017 v.120 pp. 171-176
ISSN:: 0367-326X
Subject:: Melaleuca; aldehydes; antibiotic resistance; antimicrobial properties; biochemical pathways; biomimetics; leaves; lignans; methicillin; methicillin-resistant Staphylococcus aureus; odors; spectral analysis
Abstract:: ... Phytochemical study on the leaves of Melaleuca bracteata resulted in the isolation of ten compounds including three new neolignans, named melaleucins A–C (1–3). Among them, melaleucin B shares a rarely occurring nor-neolignan skeleton, and both melaleucins B and C bear a novel aldehyde moiety, which might also be response for the delicate fragrance of M. bracteata. Their structures were extensivel ...
DOI:: 10.1016/j.fitote.2017.06.015
: https://doi.org/10.1016/j.fitote.2017.06.015

9. Antioxidant and cytotoxic lignans from the roots of Bupleurum chinense

Author:: Dan-Qi Li; Di Wang; Le Zhou; Ling-Zhi Li; Qing-Bo Liu; Ying-Ying Wu; Jing-Yu Yang; Shao-Jiang Song; Chun-Fu Wu
Source:: Journal of Asian natural products research 2017 v.19 no.5 pp. 519-527
ISSN:: 1477-2213
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Bupleurum chinense; antioxidant activity; bioactive compounds; cytotoxicity; ethanol; fluorouracil; free radical scavengers; glucosides; inhibitory concentration 50; lignans; neoplasm cells; nuclear magnetic resonance spectroscopy; roots; spectral analysis
Abstract:: ... In the search for biologically active compounds from the roots of Bupleurum chinense D C., phytochemical investigation of its ethanol extract led to the isolation and identification of a new 8- O -4′ neolignan glucoside, saikolignanoside A (1), along with eight known lignans (2–9). Their structures were determined on the basis of IR, UV, HRESIMS, and NMR spectroscopic analyses. The antioxidant and ...
DOI:: 10.1080/10286020.2016.1234456
: https://doi.org/10.1080/10286020.2016.1234456

10. Antiplasmodial Securinega alkaloids from Phyllanthus fraternus: Discovery of natural (+)-allonorsecurinine

Author:: Gustav Komlaga; Grégory Genta-Jouve; Sandrine Cojean; Rita A. Dickson; Merlin L.K. Mensah; Philippe M. Loiseau; Pierre Champy; Mehdi A. Beniddir
Source:: Tetrahedron letters 2017 pp. -
ISSN:: 0040-4039
Subject:: Phyllanthus fraternus; Plasmodium falciparum; Securinega; alkaloids; antimalarials; antiparasitic properties; chemical reactions; chemical structure; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:: ... The chemical investigation of the antimalarial plant Phyllanthus fraternus G. L. Webster (Phyllanthaceae) resulted in the discovery of the Securinega alkaloid (+)-allonorsecurinine (1), previously reported as a synthetic compound, together with the known ent-norsecurinine (2), nirurine (3), bubbialine (4), epibubbialine (5) and the lignan phyllanthin (6). The structure and absolute configuration o ...
DOI:: 10.1016/j.tetlet.2017.08.045
: https://doi.org/10.1016/j.tetlet.2017.08.045

11. Arctigenin represses TGF-β-induced epithelial mesenchymal transition in human lung cancer cells

Author:: Yanrui Xu; Zhiyuan Lou; Seong-Ho Lee
Source:: Biochemical and biophysical research communications 2017 v.493 pp. 934-939
ISSN:: 0006-291X
Subject:: Asteraceae; antineoplastic activity; beta catenin; cadherins; dose response; epithelium; humans; lignans; lung neoplasms; metastasis; mitogen-activated protein kinase; models; neoplasm cells; phosphorylation; snails; toxicity; transcription (genetics)
Abstract:: ... Arctigenin (ARC) is a lignan that is abundant in Asteraceae plants, which show anti-inflammatory and anti-cancer activities. The current study investigated whether ARC affects cancer progression and metastasis, focusing on EMT using invasive human non-small cell lung cancer (NSCLC) cells. No toxicity was observed in the cells treated with different doses of ARC (12–100 μM). The treatment of ARC re ...
DOI:: 10.1016/j.bbrc.2017.09.117
: https://doi.org/10.1016/j.bbrc.2017.09.117

12. Bifidobacterium adolescentis INIA P784: The first probiotic bacterium capable of producing enterodiol from lignan extracts

Author:: Pilar Gaya; Ángela Peirotén; Margarita Medina; José Ma Landete
Source:: Journal of functional foods 2017 v.29 pp. 269-274
ISSN:: 1756-4646
Subject:: Bifidobacterium adolescentis; bioavailability; biotechnology; functional foods; human health; intestinal microorganisms; lactic acid bacteria; lignans; linseed; matairesinol; metabolism; probiotics
Abstract:: ... Lignans are phytoestrogens found in plant foods and especially in flax seeds. Although lignans present a low bioavailability, their transformation into the enterolignans enterodiol (END) and enterolactone (ENL) is associated with beneficial effects on human health. Lignan metabolism was studied in 90 lactic acid bacteria and bifidobacteria finding a wide distribution of the ability to deglycosylat ...
DOI:: 10.1016/j.jff.2016.12.044
: https://doi.org/10.1016/j.jff.2016.12.044

13. Bioactive lignans and flavones with in vitro antioxidant and neuroprotective properties from Rubus idaeus rhizome

Author:: Yang Xu; Ling-Zhi Li; Qian Cong; Wei Wang; Xiao-Li Qi; Ying Peng; Shao-Jiang Song
Source:: Journal of functional foods 2017 v.32 pp. 160-169
ISSN:: 1756-4646
Subject:: Rubus idaeus; antioxidant activity; antioxidants; ethanol; flavones; fruits; herbal medicines; leaves; lignans; neurodegenerative diseases; neuroprotective effect; rhizomes
Abstract:: ... Rubus idaeus L. is caneberries from the genus Rubus that have been cultivated as food and herbal medicine, and is known to demonstrate strong antioxidant capability. In the present study, five new lignans, along with 13 known compounds, were isolated from ethanol extracts of R. idaeus rhizomes. An HPLC-MS/MS method was established and successfully applied to quantification of 14 compounds from lea ...
DOI:: 10.1016/j.jff.2017.02.022
: https://doi.org/10.1016/j.jff.2017.02.022

14. Can sesame consumption improve blood pressure? A systematic review and meta‐analysis of controlled trials

Author:: Hossein Khosravi‐Boroujeni; Elham Nikbakht; Ernesta Natanelov; Saman Khalesi
Source:: Journal of the science of food and agriculture 2017 v.97 no.10 pp. 3087-3094
ISSN:: 0022-5142
Subject:: blood pressure; databases; hypertension; lignans; meta-analysis; myocardial infarction; phytosterols; polyunsaturated fatty acids; renal failure; risk factors; stroke; systematic review
Abstract:: ... Hypertension is a major risk factor for cardiovascular disease, myocardial infarction, stroke and renal failure. Sesame consumption may benefit blood pressure (BP) owing to its high polyunsaturated fatty acid, fibre, phytosterol and lignan contents. To clarify this, a systematic review and meta‐analysis of controlled trials was conducted. The PubMed (MEDLINE), Cumulative Index to Nursing and Allie ...
DOI:: 10.1002/jsfa.8361
: https://doi.org/10.1002/jsfa.8361

15. Chemical Composition and UVA-Protecting Activity of Extracts from Ligustrum vulgare and Olea europaea Leaves

Author:: Monika E. Czerwińska; Katarzyna Duszak; Andrzej Parzonko; Anna K. Kiss
Source:: Acta biologica Cracoviensia 2017 v.58 no.2 pp. 45-55
ISSN:: 1898-0295
Subject:: Ligustrum vulgare; Olea europaea; apoptosis; cell viability; chemical composition; fibroblasts; flavonoids; herbal medicines; humans; leaf extracts; leaves; lignans; models; oleuropein; olives; phenylpropanoids; propidium; protective effect; reactive oxygen species; skin diseases; staining; Mediterranean region; Northern European region
Abstract:: ... Plants belonging to the family Oleaceae have been traditionally used in treatment of various inflammatory skin disorders. One of the most well-known species is Olea europaea L. (olive), cultivated in the Mediterranean countries. Another species is Ligustrum vulgare L. (common privet), occurring particularly in Northern Europe and Asia.The aim of the study was a comparison of the composition of aqu ...
DOI:: 10.1515/abcsb-2016-0016
: https://doi.org/10.1515/abcsb-2016-0016

16. Chiral separation and chemical profile of Dengzhan Shengmai by integrating comprehensive with multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

Author:: Ning Sheng; Hao Zheng; Yao Xiao; Zhe Wang; Menglin Li; Jinlan Zhang
Source:: Journal of chromatography 2017 v.1517 pp. 97-107
ISSN:: 0021-9673
Subject:: Oriental traditional medicine; chemical composition; comprehensive two-dimensional liquid chromatography; cutting; flavonoids; herbs; high performance liquid chromatography; isomers; lignans; mass spectrometry; saponins
Abstract:: ... Chemical profile for Chinese medicine formulas composed of several herbs is always a challenge due to a big array of small molecules with high chemical diversity so much as isomers. The present paper develops a feasible strategy to characterize and identify complex chemical constituents of a four-herb traditional Chinese medicine formula, Denzhan Shenmai (DZSM) by integrating comprehensive two-dim ...
DOI:: 10.1016/j.chroma.2017.08.037
: https://doi.org/10.1016/j.chroma.2017.08.037

17. Comparative analysis of the in-vitro antioxidant activity and bioactive compounds of flaxseed in China according to variety and geographical origin

Author:: Qianchun Deng; Xiao Yu; Fangli Ma; Jiqu Xu; Fenghong Huang; Qingde Huang; Feng Sheng
Source:: International journal of food properties 2017 v.20 no.sup3 pp. S2708
ISSN:: 1094-2912
Subject:: 2,2-diphenyl-1-picrylhydrazyl; alpha-linolenic acid; antioxidant activity; antioxidants; bioactive compounds; chemometrics; glucosides; lignans; linseed; p-coumaric acid; phytosterols; principal component analysis; provenance; syringic acid; China
Abstract:: ... The present study aimed to use a chemometric study to compare the in-vitro antioxidant activities and bioactive compounds of flaxseed based on the variety and geographical origins, and further explore the specific components constructed the endogenous antioxidant system of flaxseed in China. The differential contents of α-linolenic acid (35.83–58.91%), lignans (11.37–33.31 mg/g), total phenolic ac ...
DOI:: 10.1080/10942912.2017.1402029
: https://doi.org/10.1080/10942912.2017.1402029

18. Comprehensive profiling and characterization of chemical constituents of rhizome of Anemarrhena asphodeloides Bge.

Author:: De Ji; Zi-yan Huang; Cheng-hao Fei; Wei-wei Xue; Tu-lin Lu
Source:: Journal of chromatography 2017 v.1060 pp. 355-366
ISSN:: 1570-0232
Subject:: Anemarrhena asphodeloides; chemical composition; cyclic peptides; fatty acids; flavones; herbal medicines; ions; lignans; mass spectrometry; metabolites; quality control; rhizomes; steroid saponins; ultra-performance liquid chromatography; xanthones; China
Abstract:: ... The rhizome of Anemarrhena asphodeloides Bge. is commonly used as an herbal medicine in China. In this study, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) was used, in both negative and positive ion modes, to comprehensively analyze the chemical constituents of A. asphodeloides. From the intact precursor ions, MS/MS fragmenta ...
DOI:: 10.1016/j.jchromb.2017.06.032
: https://doi.org/10.1016/j.jchromb.2017.06.032

19. Cytotoxic neolignans from the traditional Chinese medicine Daphniphyllum macropodum Miq.

Author:: Xinhua Ma; Jie Yang; Christopher L. Brown; Chao Wang; Shihao Deng; Ruifang Ke; Shicheng Xu; Mi Huang; Xinzhou Yang; Yunjiang Feng
Source:: RSC advances 2017 v.7 no.83 pp. 52970-52976
ISSN:: 2046-2069
Subject:: Daphniphyllum; Oriental traditional medicine; apoptosis; benzaldehyde; caspase-3; caspase-9; cell growth; cell lines; circular dichroism spectroscopy; cytotoxicity; dose response; humans; lignans; mitochondria; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; seeds; spectral analysis
Abstract:: ... Four new neolignans, (E)-3-(hydroxymethyl)-2-(4-hydroxyphenyl)-5-(prop-1-en-1-yl)benzofuran-6-ol (1), methyl (E)-6-hydroxy-2-(4-hydroxyphenyl)-5-(prop-1-en-1-yl)benzofuran-3-carboxylate (2), (R)-4-hydroxy-3-(1-(4-hydroxyphenyl)propan-2-yl)benzaldehyde (3) and methyl (E,R)-3-(4-hydroxy-3-(1-(4-hydroxyphenyl)propan-2-yl)phenyl)acrylate (4) were isolated from the seeds of Daphniphyllum macropodum Miq ...
DOI:: 10.1039/c7ra09569d
: https://doi.org/10.1039/c7ra09569d

20. Derivatives of the Lignan 7′-Hydroxymatairesinol with Antioxidant Properties and Enhanced Lipophilicity

Author:: Moraux Thomas; Dumarçay Stéphane; Gérardin Philippe; Gérardin-Charbonnier Christine
Source:: Journal of natural products 2017 v.80 no.6 pp. 1783-1790
ISSN:: 1520-6025
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Abies alba; Picea abies; Pseudotsuga menziesii; alpha-tocopherol; antioxidant activity; ascorbic acid; butylated hydroxytoluene; esterification; hydrophobicity; inhibitory concentration 50; lignans; ultra-performance liquid chromatography
Abstract:: ... The lignan 7′-hydroxymatairesinol (1), extracted from the knotwoods of fir (Abies alba), spruce (Picea abies), and Douglas fir (Pseudotsuga menziesii), exhibited unexpected reactivity when esterification reactions were attempted on the hydroxy group at position C-7′. To circumvent the rapid intramolecular cyclization procedure, leading quantitatively to the lignan conidendrin (7), a simple strateg ...
DOI:: 10.1021/acs.jnatprod.6b01124
: https://doi.org/10.1021/acs.jnatprod.6b01124

21. Diarylpropanes and lignans from Horsfieldia tetratepala

Author:: Shou-Zhen Du; Zhi-Chong Wang; Ying Liu; Rui Zhan; Ye-Gao Chen
Source:: Phytochemistry letters 2017 v.19 pp. 98-100
ISSN:: 1874-3900
Subject:: acetone; branches; cytotoxicity; lignans; neoplasms; spectral analysis
Abstract:: ... Two new diarylpropanes (1–2), four known compounds, and a new artifact, were isolated from 70% aqueous acetone extract of the twigs of Horsfieldia tetratepala. Their structures were elucidated by spectroscopic analysis. Cytotoxicity evaluation against five cancer cell lines showed that none of these compounds was cytotoxic. ...
DOI:: 10.1016/j.phytol.2016.12.018
: https://doi.org/10.1016/j.phytol.2016.12.018

22. Diterpenoids and Lignans from Cephalotaxus fortunei

Author:: Zhao Jin-Xin; Fan Yao-Yue; Xu Jin-Biao; Gan Li-She; Xu Cheng-Hui; Ding Jian; Yue Jian-Min
Source:: Journal of natural products 2017 v.80 no.2 pp. 356-362
ISSN:: 1520-6025
Subject:: Cephalotaxus; X-ray diffraction; anticarcinogenic activity; biosynthesis; branches; chemical structure; cytotoxicity; diterpenoids; inhibitory concentration 50; leaves; lignans
Abstract:: ... Five new diterpenoids including two Cephalotaxus troponoids (1 and 2), two 17-nor-cephalotane-type diterpenoids (3 and 4), and an abietane-type diterpenoid (5), two new lignans (6 and 7), and a new trisnorneoligan (8) along with eight known compounds were identified from the twigs and leaves of Cephalotaxus fortunei. The structure of 11-hydroxyhainanolidol was revised as 10-hydroxyhainanolidol (9) ...
DOI:: 10.1021/acs.jnatprod.6b00802
: https://doi.org/10.1021/acs.jnatprod.6b00802

23. Effect of Antibiotics and Diet on Enterolactone Concentration and Metabolome Studied by Targeted and Nontargeted LC–MS Metabolomics

Author:: Bolvig Anne K.; Nørskov Natalja P.; Hedemann Mette S.; Foldager Leslie; McCarthy-Sinclair Brendan; Marco Maria L.; Lærke Helle N.; Bach Knudsen Knud E.
Source:: Journal of Proteome Research 2017 v.16 no.6 pp. 2135-2150
ISSN:: 1535-3907
Subject:: antibiotics; blood lipids; diet; epidemiological studies; humans; intestinal microorganisms; lignans; lipid composition; liquid chromatography; low density lipoprotein cholesterol; mass spectrometry; metabolism; metabolites; metabolome; metabolomics; microbial communities; proteome; ribosomal RNA; sequence analysis; swine; swine feeding
Abstract:: ... High plant lignan intake is associated with a number of health benefits, possibly induced by the lignan metabolite enterolactone (ENL). The gut microbiota plays a crucial role in converting dietary lignans into ENL, and epidemiological studies have shown that use of antibiotics is associated with lower levels of ENL. Here we investigate the link between antibiotic use and lignan metabolism in pigs ...
DOI:: 10.1021/acs.jproteome.6b00942
: https://doi.org/10.1021/acs.jproteome.6b00942

24. Enantiomeric 8-O-4′ type neolignans from red raspberry as potential inhibitors of β-amyloid aggregation

Author:: Le Zhou; Li-Li Lou; Wei Wang; Bin Lin; Jun-Ning Chen; Xiao-Bo Wang; Xiao-Xiao Huang; Shao-Jiang Song
Source:: Journal of functional foods 2017 v.37 pp. 322-329
ISSN:: 1756-4646
Subject:: Alzheimer disease; Rubus idaeus; chemical composition; chemical structure; functional foods; lignans; neuroprotective effect; spectral analysis; stereochemistry
Abstract:: ... Red raspberry (Rubus idaeus L.) is an edible fruit-producing species belonging to the Rosaceae family. In our search for potential agents for treating Alzheimer’s disease in this functional food, we decided to investigate the chemical constituents of red raspberry. Four pairs of enantiomeric 8-O-4′-type neolignans (1a/1b–4a/4b), including three new compounds (1a/1b and 2a), were identified from th ...
DOI:: 10.1016/j.jff.2017.08.007
: https://doi.org/10.1016/j.jff.2017.08.007

25. Expression in Pichia pastoris and characterization of two novel dirigent proteins for atropselective formation of gossypol

Author:: Isabelle Effenberger; Michael Harport; Jens Pfannstiel; Iris Klaiber; Andreas Schaller
Source:: Applied microbiology and biotechnology 2017 v.101 no.5 pp. 2021-2032
ISSN:: 0175-7598
Subject:: cotton; proteins; biosynthesis; Komagataella pastoris; free radicals; glycosylation; biomimetics; gossypol; Gossypium barbadense; lignans; affinity chromatography; mass spectrometry; batch fermentation
Abstract:: ... We established an efficient fed-batch fermentation process for two novel dirigent proteins from cotton plants, GbDIR2 from Gossypium barbadense and GhDIR3 from G. hirsutum, using the engineered Pichia pastoris GlycoSwitch® SuperMan₅ strain to prevent hyperglycosylation. The two (His)₆-tagged proteins were purified by metal-chelate affinity chromatography and obtained in quantities of 12 and 15 mg ...
DOI:: 10.1007/s00253-016-7997-3
: https://doi.org/10.1007/s00253-016-7997-3

26. Extraction of Flaxseed Oil: A Comparative Study of Three-Phase Partitioning and Supercritical Carbon Dioxide Using Response Surface Methodology

Author:: Nikhil G Kulkarni; Jayaranjan R Kar; Rekha S Singhal
Source:: Food and bioprocess technology 2017 v.10 no.5 pp. 940-948
ISSN:: 1935-5130
Subject:: 2,2-diphenyl-1-picrylhydrazyl; acid value; antioxidant activity; carbon dioxide; cooking fats and oils; economic sustainability; free radical scavengers; iodine value; lignans; linseed; linseed oil; omega-3 fatty acids; oxidative stability; peroxide value; proteins; response surface methodology; solvents; supercritical fluid extraction; ultrasonics
Abstract:: ... Flaxseed has gained significant interest as a source of edible oil that is rich in omega-3 fatty acids, high content of flaxseed proteins and lignans that are known to be therapeutic. Low oxidative stability of flaxseed oil necessitates the use of extraction technologies that are advanced and economically viable than the currently used cold press extraction. This work compares the yield and qualit ...
DOI:: 10.1007/s11947-017-1877-4
: https://doi.org/10.1007/s11947-017-1877-4

27. Extraction of bioactive compounds from sesame (Sesamum indicum L.) defatted seeds using water and ethanol under sub-critical conditions

Author:: Romina Bodoira; Alexis Velez; Alfonsina E. Andreatta; Marcela Martínez; Damián Maestri
Source:: Food chemistry 2017 v.237 pp. 114-120
ISSN:: 0308-8146
Subject:: Sesamum indicum; ambient temperature; bioactive compounds; butylated hydroxytoluene; ethanol; gallic acid; lignans; phenols; quercetin; response surface methodology; seeds; sesame cake; sesame seed
Abstract:: ... Sesame seeds contain a vast array of lignans and phenolic compounds having important biological properties. An optimized method to obtain these seed components was designed by using water and ethanol at high pressure and temperature conditions. The maximum concentrations of lignans, total phenolics, flavonoids and flavonols compounds were achieved at 220°C extraction temperature and 8MPa pressure, ...
DOI:: 10.1016/j.foodchem.2017.05.102
: https://doi.org/10.1016/j.foodchem.2017.05.102

28. Fargesin exerts anti-inflammatory effects in THP-1 monocytes by suppressing PKC-dependent AP-1 and NF-ĸB signaling

Author:: Thu-Huyen Pham; Man-Sub Kim; Minh-Quan Le; Yong-Seok Song; Yesol Bak; Hyung-Won Ryu; Sei-Ryang Oh; Do-Young Yoon
Source:: Phytomedicine 2017 v.24 pp. 96-103
ISSN:: 0944-7113
Subject:: Magnolia biondii; Oriental traditional medicine; Western blotting; anti-inflammatory activity; chemokines; drugs; enzyme-linked immunosorbent assay; fluorescent antibody technique; genes; humans; inducible nitric oxide synthase; interleukin-1beta; lignans; luciferase; messenger RNA; mitogen-activated protein kinase; monocytes; nose; prostaglandin synthase; protein kinase C; protein synthesis; quantitative polymerase chain reaction; sinusitis; transcription factor NF-kappa B; tumor necrosis factor-alpha; viability
Abstract:: ... Fargesin is a lignan from Magnolia fargesii, an oriental medicine used in the treatment of nasal congestion and sinusitis. The anti-inflammatory properties of this compound have not been fully elucidated yet.This study focused on assessing the anti-inflammatory effects of fargesin on phorbal ester (PMA)-stimulated THP-1 human monocytes, and the molecular mechanisms underlying them.Cell viability w ...
DOI:: 10.1016/j.phymed.2016.11.014
: https://doi.org/10.1016/j.phymed.2016.11.014

29. Flavonol glycosides and lignans from the leaves of Opilia amentacea

Author:: Abdulmagid Alabdul Magid; Anaëlle Abdellah; Virginie Pecher; Laure Pasquier; Dominique Harakat; Laurence Voutquenne-Nazabadioko
Source:: Phytochemistry letters 2017 v.21 pp. 84-89
ISSN:: 1874-3900
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Opiliaceae; antioxidant activity; flavonols; glycosides; inhibitory concentration 50; leaves; lignans; mushrooms; spectral analysis
Abstract:: ... Two previously undescribed flavonol tetraglycosides, isorhamnetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (1) and isorhamnetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside (2), along with nine known compounds including seven flavonoids and two lignans, were isolated from the l ...
DOI:: 10.1016/j.phytol.2017.05.023
: https://doi.org/10.1016/j.phytol.2017.05.023

30. Flaxseed and multigrain mixtures in the development of functional biscuits

Author:: Nikolina Čukelj; Dubravka Novotni; Hrvoje Sarajlija; Saša Drakula; Bojana Voučko; Duška Ćurić
Source:: Lebensmittel-Wissenschaft + Technologie 2017 v.86 pp. 85-92
ISSN:: 0023-6438
Subject:: antioxidant activity; baking; barley; bioavailability; biscuits; ingredients; lignans; linseed; lipid peroxidation; markets; oat flour; oats; oxidative stability; phenolic acids; rye; sensory properties; texture; wheat
Abstract:: ... Market reports show an increasing interest for healthy biscuits, with omega-3 and lignan rich flaxseeds being highlighted as key ingredients. Usage of milled flaxseed in comparison to the whole seed might improve bioaccessibility of lignans and omega-3, but also accelerate lipid oxidation, thus diminishing the consumers' acceptability.This research investigated the nutritional (lignans, omega-3, p ...
DOI:: 10.1016/j.lwt.2017.07.048
: https://doi.org/10.1016/j.lwt.2017.07.048

31. Functional characterization of the pinoresinol–lariciresinol reductase-2 gene reveals its roles in yatein biosynthesis and flax defense response

Author:: Cyrielle Corbin; Samantha Drouet; Ivan Mateljak; Lucija Markulin; Cédric Decourtil; Sullivan Renouard; Tatiana Lopez; Joël Doussot; Frédéric Lamblin; Daniel Auguin; Eric Lainé; Elisabeth Fuss; Christophe Hano
Source:: Planta 2017 v.246 no.3 pp. 405-420
ISSN:: 0032-0935
Subject:: Linum usitatissimum; RNA interference; aerial parts; biosynthesis; enantiomers; enzymes; flax; genes; leaves; lignans; methyl jasmonate; quantitative polymerase chain reaction; regulatory sequences; reverse transcriptase polymerase chain reaction; seeds; stress response; tissues; transgenesis
Abstract:: ... MAIN CONCLUSION: This study provides new insights into the biosynthesis regulation and in planta function of the lignan yatein in flax leaves. Pinoresinol–lariciresinol reductases (PLR) catalyze the conversion of pinoresinol into secoisolariciresinol (SECO) in lignan biosynthesis. Several lignans are accumulated in high concentrations, such as SECO accumulated as secoisolariciresinol diglucoside ( ...
DOI:: 10.1007/s00425-017-2701-0
: https://doi.org/10.1007/s00425-017-2701-0

32. Furofuran lignan glucosides from the leaves of Vitex negundo var. cannabifolia

Author:: Yue-Ting Li; Man-Man Li; Jing Sun; Zhi-Xiang Zhu; Yue-Lin Song; Dao-Ran Pang; Jiao Zheng; Yun-Fang Zhao; Peng-Fei Tu; Jun Li
Source:: Natural product research 2017 v.31 no.8 pp. 918-924
ISSN:: 1478-6427
Subject:: Vitex negundo; glucosides; inhibitory concentration 50; leaves; lignans; nitric oxide; spectral analysis; spectroscopy
Abstract:: ... Two new furofuran lignan glucosides, cannabilignin (1) and isocannabilignin (2), together with four known compounds (3 – 6), were isolated from the leaves of Vitex negundo var. cannabifolia . The structures of the isolates were elucidated by analysis of spectroscopic data. Compound 3 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC ...
DOI:: 10.1080/14786419.2016.1255887
: https://doi.org/10.1080/14786419.2016.1255887

33. Furofuran lignans from the Simpson Desert species Eremophila macdonnellii

Author:: Yuen P. Tan; Andrei I. Savchenko; Natasa Broit; Glen M. Boyle; Peter G. Parsons; Craig M. Williams
Source:: Fitoterapia 2017 pp. -
ISSN:: 0367-326X
Subject:: antineoplastic activity; arid zones; breast neoplasms; lignans; phytopharmaceuticals; traditional medicine; Australia
Abstract:: ... The Eremophila plant family, which occurs in the arid zones of Australia, have witnessed extensive investigation, mostly inspired by Aboriginal traditional medicine. A wide and varied biological and phytochemical profile has been reported for over 18 individual species of Australian Eremophila, although E. macdonnellii from the Simpson Desert has not yet been investigated. Isolation and elucidatio ...
DOI:: 10.1016/j.fitote.2017.06.004
: https://doi.org/10.1016/j.fitote.2017.06.004

34. Identification of metabolites in human and rat urine after oral administration of Xiao‐Qing‐Long‐Tang granule using ultra high performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

Author:: Lei Zhou; Qiang Zhang; Wen Qi; Shuai Yan; Jialin Qu; Toshiaki Makino; Dan Yuan
Source:: Journal of separation science 2017 v.40 no.18 pp. 3582-3592
ISSN:: 1615-9306
Subject:: alkaloids; biochemical pathways; bronchitis; chemical composition; computer software; essential oils; flavones; ginger; humans; hydroxylation; hypersensitivity; lignans; metabolism; metabolites; nose; oral administration; prototypes; rats; tandem mass spectrometry; ultra-performance liquid chromatography; urine
Abstract:: ... Xiao‐Qing‐Long‐Tang is a traditional Chinese formula used for the treatment of cold syndrome, bronchitis, and nasal allergies for thousands of years. However, the in vivo integrated metabolism of its multiple components and the active chemical constituents of Xiao‐Qing‐Long‐Tang remain unknown. In this study, a method using ultra high performance liquid chromatography coupled with quadrupole time‐ ...
DOI:: 10.1002/jssc.201700423
: https://doi.org/10.1002/jssc.201700423

35. Impact of lignans on the polyunsaturated fatty acid metabolic processing in a rainbow trout (Oncorhynchus mykiss) cell line

Author:: Julie Mellery; Florian Scalisi; Chloé Bonnineau; Patrick Kestemont; Xavier Rollin; Yvan Larondelle
Source:: Aquaculture 2017 v.476 pp. 106-110
ISSN:: 0044-8486
Subject:: Oncorhynchus mykiss; alpha-linolenic acid; biotransformation; diet; eicosapentaenoic acid; fish; fish feeds; fish oils; hepatocytes; in vitro studies; lignans; linseed; linseed oil; lipid metabolism; omega-3 fatty acids; sesame oil; sesame seed
Abstract:: ... In the context of fish oil replacement by alternative plant-derived oils in the fish feed, the influence of lignans, which are phenolic compounds present at significant concentrations in some plant-derived oils, was investigated on the omega-3 (n-3) fatty acid metabolism of the rainbow trout liver cell line RTL-W1 enriched in alpha-linolenic acid (ALA, 18:3n-3). The major linseed oil lignans, name ...
DOI:: 10.1016/j.aquaculture.2017.04.022
: https://doi.org/10.1016/j.aquaculture.2017.04.022

36. In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans

Author:: Puttaraju Srikantamurthy Yashaswini; Bettadahalli Sadashivaiah; Talahalli Ravichandra Ramaprasad; Sridevi Annapurna Singh
Source:: Journal of nutritional biochemistry 2017 v.41 pp. 151-157
ISSN:: 0955-2863
Subject:: blood serum; catalase; glutathione-disulfide reductase; inflammation; interleukin-1beta; leukotrienes; lignans; lipid peroxidation; liver; metabolic diseases; oxidative stress; rats; sesame oil; superoxide dismutase; therapeutics; tumor necrosis factor-alpha
Abstract:: ... The role of inflammation and oxidative stress is critical during onset of metabolic disorders and this has been sufficiently established in literature. In the present study, we evaluated the effects of sesamol and sesamin, two important bioactive molecules present in sesame oil, on the generation of inflammatory and oxidative stress factors in LPS injected rats. Sesamol and sesamin lowered LPS ind ...
DOI:: 10.1016/j.jnutbio.2016.12.010
: https://doi.org/10.1016/j.jnutbio.2016.12.010

37. Kudsuphilactone B, a nortriterpenoid isolated from Schisandra chinensis fruit, induces caspase-dependent apoptosis in human ovarian cancer A2780 cells

Author:: Miran Jeong; Hye Mi Kim; Hyun Ji Kim; Jung-Hye Choi; Dae Sik Jang
Source:: Archives of pharmacal research 2017 v.40 no.4 pp. 500-508
ISSN:: 0253-6269
Subject:: 4-hydroxybenzoic acid; B-cell lymphoma; NAD ADP-ribosyltransferase; Schisandra chinensis; acetates; apoptosis; caspase-3; cytotoxicity; dose response; fruits; humans; indole acetic acid; inhibitory concentration 50; lignans; mitogen-activated protein kinase; neoplasm cells; ovarian neoplasms; plant ovary; proteins; protocatechuic acid; uterine neoplasms
Abstract:: ... A phytochemical study on the fruits of Schisandra chinensis led to the isolation and characterization of nineteen compounds. The structures of the isolates were determined to be schizandrin, deoxyschizandrin, angeloylgomisin H, gomisin A, gomisin J, (−)-gomisin L₁, (−)-gomisin L₂, wuweizisu C, gomisin N, meso-dihydroguaiaretic acid, kadsuphilactone B, α-ylangenol, α-ylangenyl acetate, β-chamigrena ...
DOI:: 10.1007/s12272-017-0902-5
: https://doi.org/10.1007/s12272-017-0902-5

38. LC-MS profiling highlights hazelnut (Nocciola di Giffoni PGI) shells as a byproduct rich in antioxidant phenolics

Author:: Milena Masullo; Antonietta Cerulli; Angela Mari; Carla Clisiane de Souza Santos; Cosimo Pizza; Sonia Piacente
Source:: Food research international 2017 v.101 pp. 180-187
ISSN:: 0963-9969
Subject:: 2,2-diphenyl-1-picrylhydrazyl; antioxidant activity; antioxidants; bioactive compounds; byproducts; cultivars; cytotoxicity; economic resources; fibroblasts; flavonoids; hazelnuts; humans; ionization; lignans; liquid chromatography; markets; mass spectrometry; methanol; monitoring; neoplasms; nuclear magnetic resonance spectroscopy; protected designation of origin; quantitative analysis
Abstract:: ... The Italian “Nocciola di Giffoni”, also known as “Tonda di Giffoni”, a labelled Protected Geographical Indication (PGI) product, represents an important economic resource for the Italian market. The methanol (MeOH) extract of “Tonda di Giffoni” shells has been investigated for the phenolic content, assayed by the Folin-Ciocalteu method, and for the antioxidant activity by the 1,1-diphenyl-2-picryl ...
DOI:: 10.1016/j.foodres.2017.08.063
: https://doi.org/10.1016/j.foodres.2017.08.063

39. Lignans and diterpenes isolated from Tirpitzia ovoidea and their biological activities

Author:: Xue-Yan YANG; Yi-Fan ZHANG; Li-Jia LIU; Yi WANG; Ming-Ying SHANG; Feng XU; Guang-Xue LIU; Shao-Qing CAI
Source:: Chinese journal of natural medicines 2017 v.15 no.12 pp. 938-943
ISSN:: 1875-5364
Subject:: Linaceae; Oriental traditional medicine; aerial parts; anti-inflammatory activity; cell lines; cytotoxicity; diterpenoids; ethanol; ethyl acetate; inflammation; inhibitory concentration 50; lignans; macrophages; mice; models; nitric oxide; spectral analysis
Abstract:: ... A new lignan, tirpitzin A (17) together with 20 known compounds (1–16, and 18–21) were isolated from the ethyl acetate soluble fraction of ethanol extract of the aerial parts of Tirpitzia ovoidea. The structure of new compound was elucidated by means of spectroscopic analysis. Of the known compounds, 7–21 were isolated from Linaceae family for the first time. The pharmacological activity of the cr ...
DOI:: 10.1016/S1875-5364(18)30010-4
: https://doi.org/10.1016/S1875-5364(18)30010-4

40. Lignans and indole alkaloids from the seeds of Centaurea vlachorum Hartvig (Asteraceae), growing wild in Albania and their biological activity

Author:: Entela Hodaj; Olga Tsiftsoglou; Sokol Abazi; Dimitra Hadjipavlou-Litina; Diamanto Lazari
Source:: Natural product research 2017 v.31 no.10 pp. 1195-1200
ISSN:: 1478-6427
Subject:: Centaurea; linoleic acid; seeds; bioactive properties; serotonin; 2,2-diphenyl-1-picrylhydrazyl; linoleate 13S-lipoxygenase; soybeans; free radical scavengers; secondary metabolites; indole alkaloids; lignans; in vitro studies; peroxidation; matairesinol; Albania
Abstract:: ... The present phytochemical investigation of the seeds of Centaurea vlachorum led to the isolation and characterisation of four compounds including two indole alkaloids N-(p-coumaroyl) serotonin (1) and moschamine (2) and two dibenzylbutyrolactone lignans matairesinol (3) and arctiin (4). This is the first report on the isolation of non-volatile secondary metabolites from C. vlachorum. The chemataxo ...
DOI:: 10.1080/14786419.2016.1226823
: https://doi.org/10.1080/14786419.2016.1226823

41. Lignans from guaiac resin decrease nitric oxide production in interleukin 1β-treated hepatocytes

Author:: Yuki Nakano; Masaaki Nasu; Mana Kano; Hiroshi Kameoka; Tetsuya Okuyama; Mikio Nishizawa; Yukinobu Ikeya
Source:: Natural medicines 2017 v.71 no.1 pp. 190-197
ISSN:: 1340-3443
Subject:: Guaiacum officinale; anti-inflammatory activity; drugs; heartwood; hepatocytes; interleukin-1beta; lignans; monitoring; nitric oxide; rats
Abstract:: ... Guaiac resin, extracted from the heartwood of Guaiacum officinale L. or G. sanctum L., is speculated to have anti-inflammatory effects. Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1β (IL-1β). Six lignans were purified from guaiac resin and identified as: dehy ...
DOI:: 10.1007/s11418-016-1048-3
: https://doi.org/10.1007/s11418-016-1048-3

42. Lignans from the shed trunk barks of the critically endangered plant Abies beshanzuensis and their anti-neuroinflammatory activities

Author:: Chang-Ling Hu; Juan Xiong; Peng Xu; Ke-Jun Cheng; Guo-Xun Yang; Jin-Feng Hu
Source:: Natural product research 2017 v.31 no.12 pp. 1358-1364
ISSN:: 1478-6427
Subject:: Abies; inhibitory concentration 50; lignans; mice; nitric oxide; plants (botany); spectral analysis
Abstract:: ... During a further and comprehensive phytochemical investigation on the shed trunk barks of the critically endangered plant Abies beshanzuensis , one new (1) and ten known (2 – 11) lignans with diverse structures were isolated. On the basis of spectroscopic methods, the new structure was established to be (7 S ,8 R ,8′ R)-4′-methoxyl- α -conidendrin (1). Among the isolated lignans, (−)-matairesinol ...
DOI:: 10.1080/14786419.2016.1247082
: https://doi.org/10.1080/14786419.2016.1247082

43. Metabolic signatures altered by in vitro temperature stress in Ajuga bracteosa Wall. ex. Benth.

Author:: Rehana Rani; Mubarak Ali Khan; Waqas Khan Kayani; Sami Ullah; Ijaz Naeem; Bushra Mirza
Source:: Acta physiologiae plantarum 2017 v.39 no.4 pp. 97
ISSN:: 0137-5881
Subject:: Ajuga; biosynthesis; caffeic acid; cinnamic acid; electrospray ionization mass spectrometry; flavonoids; glucose; glutamine; histidine; ions; lignans; methionine; pentose phosphate cycle; phosphates; principal component analysis; secondary metabolites; serine; temperature; tricarboxylic acid cycle
Abstract:: ... To elucidate how biosynthesis of plant metabolites is affected by temperature, metabolite profiles from in vitro regenerated plants raised under different temperature regimes of 10, 15 °C, 20 °C, 25 °C and 30 °C were obtained using electrospray ionization mass spectrometry (ESI-MS), and principal component analysis (PCA) was carried out to identify key metabolites. Several bin masses were detected ...
DOI:: 10.1007/s11738-017-2394-9
: https://doi.org/10.1007/s11738-017-2394-9

44. Methyl caffeate and some plant constituents inhibit age-related inflammation: effects on senescence-associated secretory phenotype (SASP) formation

Author:: Hyun Lim; Byung Kyu Park; Sook Young Shin; Yong Soo Kwon; Hyun Pyo Kim
Source:: Archives of pharmacal research 2017 v.40 no.4 pp. 524-535
ISSN:: 0253-6269
Subject:: anthraquinones; caffeic acid; chemokine CXCL1; fibroblasts; flavonoids; gene expression; granulocyte-macrophage colony-stimulating factor; inflammation; interleukin-1alpha; interleukin-1beta; interleukin-6; interleukin-8; lignans; messenger RNA; phenotype; phenylpropanoids; transcription factor NF-kappa B
Abstract:: ... During aging, cells secrete molecules called senescence-associated secretory phenotype (SASP). They constitute chronic low-grade inflammation environment to adjacent cells and tissues. In order to find inhibiting agents of SASP formation, 113 plant constituents were incubated with BJ fibroblasts for 6 days after treatment with bleomycin. Several plant constituents showed considerable inhibition of ...
DOI:: 10.1007/s12272-017-0909-y
: https://doi.org/10.1007/s12272-017-0909-y

45. Micro-matrix solid-phase dispersion coupled with MEEKC for quantitative analysis of lignans in Schisandrae Chinensis Fructus using molecular sieve TS-1 as a sorbent

Author:: Chu Chu; Mengmeng Wei; Shan Wang; Liqiong Zheng; Zheng He; Jun Cao; Jizhong Yan
Source:: Journal of chromatography 2017 v.1063 pp. 174-179
ISSN:: 1570-0232
Subject:: chromatography; grinding; lignans; methanol; oils; quantitative analysis; solid phase extraction; solvents; sorbents
Abstract:: ... A simple and effective method was developed for determining lignans in Schisandrae Chinensis Fructus by using a micro-matrix solid phase dispersion (MSPD) technique coupled with microemulsion electrokinetic chromatography (MEEKC). Molecular sieve, TS-1, was applied as a solid supporting material in micro MSPD extraction for the first time. Parameters that affect extraction efficiency, such as type ...
DOI:: 10.1016/j.jchromb.2017.08.024
: https://doi.org/10.1016/j.jchromb.2017.08.024

46. Musts with Increased Lignan Content Through Addition of Lignan Extracts

Author:: Josef Balík; Pavel Híc; Jana Kulichová; Pavla Novotná; Jan Tříska; Naděžda Vrchotová; Jan Strohalm; Danuše Lefnerová; Milan Houška
Source:: Food and bioprocess technology 2017 v.10 no.7 pp. 1367-1373
ISSN:: 1935-5130
Subject:: Picea; antioxidant activity; ethanol; grape must; grapes; knots; lignans; polyphenols; storage time; sugars
Abstract:: ... Red and white grape musts were enriched with 7-hydroxymatairesinol (HMR), which is the main lignan contained in spruce knots. Lignan enrichment was achieved by adding a spruce knot ethanol extract. Enriched musts were stored for 12 months and during storage must samples were periodically analyzed for HMR and alpha-conidendrin content, antioxidant activity, total polyphenols, and anti-mutagenicity. ...
DOI:: 10.1007/s11947-017-1911-6
: https://doi.org/10.1007/s11947-017-1911-6

47. Neolignan and megastigmane glucosides from the aerial parts of Isodon japonicus with cell protective effects on BaP-induced cytotoxicity

Author:: Takahiro Matsumoto; Seikou Nakamura; Souichi Nakashima; Tomoe Ohta; Keiko Ogawa; Masashi Fukaya; Junko Tsukioka; Tomohiro Hasei; Tetsushi Watanabe; Hisashi Matsuda
Source:: Phytochemistry 2017 v.137 pp. 101-108
ISSN:: 0031-9422
Subject:: aerial parts; chemical structure; cytotoxicity; glucosides; lignans; nuclear magnetic resonance spectroscopy; protective effect; spectral analysis; Japan
Abstract:: ... Six neolignan glucosides, named isodonosides I–VI, and a megastigmane glucoside named isodonmegastigmane I, were isolated together with 15 known compounds from the methanolic extract of aerial parts of Isodon japonicus cultivated in Tokushima, Japan. The chemical structures of the compounds were elucidated based on their MS and NMR spectroscopic analysis. The absolute configurations of the neolign ...
DOI:: 10.1016/j.phytochem.2017.02.007
: https://doi.org/10.1016/j.phytochem.2017.02.007

48. Neolignan and monoterpene glycoside from the seeds of Pharbitis nil

Author:: Seoung Rak Lee; Eunjung Moon; Ki Hyun Kim
Source:: Phytochemistry letters 2017 v.20 pp. 98-101
ISSN:: 1874-3900
Subject:: Ipomoea nil; anti-inflammatory activity; chemical structure; cytotoxicity; ethanol; glycosides; inhibitory concentration 50; lignans; lipopolysaccharides; mice; monoterpenoids; nitric oxide; nuclear magnetic resonance spectroscopy; seeds; spectral analysis
Abstract:: ... Phytochemical investigation of an EtOH extract of Pharbitis nil seeds (Convolvulaceae) resulted in the isolation and identification of a new neolignan, 7R,8S-threo-dihydroxydehydrodiconiferyl alcohol (1), and a new monoterpene glycoside, (3Z,7S)-7-hydroxy-3,7-dimethyl-3,8-octadienyl-β-d-glucopyranoside (2), together with a known compound, ethyl α-l-arabinofuranoside (3). The chemical structures of ...
DOI:: 10.1016/j.phytol.2017.04.019
: https://doi.org/10.1016/j.phytol.2017.04.019

49. Neuroprotective Lignans from the Fruits of Schisandra bicolor var. tuberculata

Author:: Liu Ye; Yu Heng-Yi; Wang Yan-Mei; Tian Tian; Wu Wen-Ming; Zhou Ming; Meng Xiang-Gao; Ruan Han-Li
Source:: Journal of natural products 2017 v.80 no.4 pp. 1117-1124
ISSN:: 1520-6025
Subject:: Schisandra; X-ray diffraction; chemical structure; fruits; hydrogen peroxide; irradiation; lignans; models; neuroprotective effect; spectral analysis
Abstract:: ... Nine new lignans (1–9) and ten known analogues (10–19) were isolated from the fruits of Schisandra bicolor var. tuberculata. The structures of compounds 1–9 were established on the basis of spectroscopic data analysis. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction analysis with Cu Kα irradiation techniques, and the absolute configurations of compounds ...
DOI:: 10.1021/acs.jnatprod.7b00035
: https://doi.org/10.1021/acs.jnatprod.7b00035

50. New isobaric lignans from Refined Olive Oils as quality markers for Virgin Olive Oils

Author:: Lorenzo Cecchi; Marzia Innocenti; Fabrizio Melani; Marzia Migliorini; Lanfranco Conte; Nadia Mulinacci
Source:: Food chemistry 2017 v.219 pp. 148-157
ISSN:: 0308-8146
Subject:: bleaching; chemical structure; chromatography; deodorization; extra-virgin olive oil; lignans; oil refining; Italy; Spain; Tunisia
Abstract:: ... Herein we describe the influence of olive oil refining processes on the lignan profile. The detection of new isobaric lignans is suggested to reveal frauds in commercial extra-Virgin Olive Oils. We analyzed five commercial olive oils by HPLC-DAD-TOF/MS to evaluate their lignan content and detected, for the first time, some isobaric forms of natural (+)-pinoresinol and (+)-1-acetoxypinoresinol. The ...
DOI:: 10.1016/j.foodchem.2016.09.132
: https://doi.org/10.1016/j.foodchem.2016.09.132

51. New lignan glycosides from Justicia procumbens

Author:: Hong Jin; Shu Yang; Jun-Xing Dong
Source:: Journal of Asian natural products research 2017 v.19 no.1 pp. 1-8
ISSN:: 1477-2213
Subject:: Justicia procumbens; glycosides; lignans; mass spectrometry; nuclear magnetic resonance spectroscopy
Abstract:: ... Four new lignan glycosides (1 – 4), named procumbenosides I, K, L, and M, together with cleistanthin B (5) reported for the first time in the genus Justicia , and 5 other known arylnaphthalene lignan glycosides (6 – 10) were isolated from the whole plant of Justicia procumbens . The structures of the new compounds were elucidated by extensive one-dimensional (1D) and two-dimensional (2D) NMR exper ...
DOI:: 10.1080/10286020.2016.1241771
: https://doi.org/10.1080/10286020.2016.1241771

52. New neolignan glycoside from the root of Aralia echinocaulis Hand. -Mazz

Author:: Yunzhi Li; Hui Cheng; Ren Yue; Mengmeng Duan; Mingdong Liu
Source:: Natural product research 2017 v.31 no.9 pp. 1047-1051
ISSN:: 1478-6427
Subject:: Aralia; chemical structure; ionization; lignans; nuclear magnetic resonance spectroscopy; saponins
Abstract:: ... A phytochemical investigation was carried out to the root of Aralia echinocauis , and a new neolignan glycoside, 3-{3,5-dimethoxy-4β- d -Glucopyranoside-2-[3-(3-β- d -Glucopyranoside-4-methoxy-phenyl)-allyl]-phenyl}-prop-2-en-1-ol (1), together with a known saponin, araliasaponin II (2) for the first time was obtained . The chemical structure of compound 1 was identified mainly by the analysis of ...
DOI:: 10.1080/14786419.2016.1269095
: https://doi.org/10.1080/14786419.2016.1269095

53. Phenylpropanoids from the fruits of Nicandra physaloides and their anti-inflammatory activities

Author:: Bing You Yang; Yan Liu; Hai Bing Jiang; Zhen Peng Xu; Rui Guo; Rui Wang; Xiao Mao Li; Hai Xue Kuang
Source:: Natural product research 2017 v.31 no.22 pp. 2634-2640
ISSN:: 1478-6427
Subject:: Nicandra; anti-inflammatory activity; fruits; inhibitory concentration 50; mass spectrometry; nitric oxide; nuclear magnetic resonance spectroscopy; phenylpropanoids
Abstract:: ... Twenty-one phenylpropanoids, including 1 new (1) and 20 known phenylpropanoids (2–21), were isolated and identified from the fruits of Nicandra physaloides . The structures of these compounds were established by 1D and 2D NMR spectra referring to the literatures, together with mass spectrometry. It was found that the isolated compounds, except for 7 , 18 and 19 , showed the different levels of inh ...
DOI:: 10.1080/14786419.2017.1289202
: https://doi.org/10.1080/14786419.2017.1289202

54. Physiological effects of γ-linolenic acid and sesamin on hepatic fatty acid synthesis and oxidation

Author:: Takashi Ide; Haruka Iwase; Saaya Amano; Saki Sunahara; Ayuka Tachihara; Minako Yagi; Tsuyoshi Watanabe
Source:: Journal of nutritional biochemistry 2017 v.41 pp. 42-55
ISSN:: 0955-2863
Subject:: acyl coenzyme A; beta oxidation; blood lipids; dietary supplements; evening primrose oil; experimental diets; fatty acid metabolism; gamma-linolenic acid; lignans; linoleic acid; lipoproteins; malic enzyme; messenger RNA; organelles; oxidation; palm oils; rats; safflower oil; saturated fats
Abstract:: ... Interrelated effects of γ-linolenic acid (GLA) and sesamin, a sesame lignan, on hepatic fatty acid synthesis and oxidation were examined. Rats were fed experimental diets supplemented with 0 or 2 g/kg sesamin (1:1 mixture of sesamin and episesamin) and containing 100 g/kg of palm oil (saturated fat), safflower oil rich in linoleic acid, or oil of evening primrose origin containing 43% GLA (GLA oil ...
DOI:: 10.1016/j.jnutbio.2016.12.001
: https://doi.org/10.1016/j.jnutbio.2016.12.001

55. Phytochemical analysis of bark from Helietta apiculata Benth and antimicrobial activities

Author:: Tanize S. Fernandes; Daniele Copetti; Gabriele do Carmo; Alexandre T. Neto; Marcelo Pedroso; Ubiratan F. Silva; Marco A. Mostardeiro; Robert E. Burrow; Ionara I. Dalcol; Ademir F. Morel
Source:: Phytochemistry 2017 v.141 pp. 131-139
ISSN:: 0031-9422
Subject:: Helietta; X-radiation; alkaloids; antimicrobial properties; bark; cinnamic acid; coumarin; crystal structure; lignans; quinolones; spectroscopy
Abstract:: ... Extraction and characterization of natural products from the bark of the trunk of Helietta apiculata Benth (Rutaceae) afforded nine alkaloids, eight furoquinoline and one quinolone, limonine, three cinnamic acid derivatives, three neolignans, tetracosanoic acid, six coumarins, of which apiculin A and apiculin B (neolignans), and tanizin (coumarin) are previously undescribed compounds. The structur ...
DOI:: 10.1016/j.phytochem.2017.05.017
: https://doi.org/10.1016/j.phytochem.2017.05.017

56. Phytochemicals and biological activities of Artemisia sieversiana

Author:: Shi-Jun Liu; Zhi-Xin Liao; Zhi-Shu Tang; Chun-Li Cui; Hong-Bo Liu; Yan-Ni Liang; Yu Zhang; Huan-Xian Shi; Yao-Run Liu
Source:: Phytochemistry reviews 2017 v.16 no.3 pp. 441-460
ISSN:: 1568-7767
Subject:: Artemisia; alkaloids; antioxidant activity; chemical composition; diterpenoids; flavonoids; lignans; phytopharmaceuticals; sesquiterpenoids; steroids
Abstract:: ... This review discusses a whole plant’s chemical nature and biological effects of Artemisia sieversiana Ehrhart ex willd (ASS). Several types of chemical compositions have been isolated from A. sieversiana, including 26 terpenoids (21 guaiane-type sesquiterpenes, 3 germacrane-type sesquiterpenes, 1 muurolane-type sesquiterpene, and 1 diterpenoid), 16 sesamin-type lignans, 9 flavonoids, 3 steroids, a ...
DOI:: 10.1007/s11101-016-9475-z
: https://doi.org/10.1007/s11101-016-9475-z

57. Pinus pinaster Knot: A Source of Polyphenols against Plasmopara viticola

Author:: Gabaston Julien; Richard Tristan; Cluzet Stéphanie; Palos Pinto Antonio; Dufour Marie-Cécile; Corio-Costet Marie-France; Mérillon Jean-Michel
Source:: Journal of agricultural and food chemistry 2017 v.65 no.40 pp. 8884-8891
ISSN:: 1520-5118
Subject:: Pinus pinaster; Plasmopara viticola; antifungal properties; biomass; byproducts; caffeic acid; ferulic acid; lignans; matairesinol; mildews; nuclear magnetic resonance spectroscopy; polyphenols; pterostilbene; taxifolin; zoospores
Abstract:: ... Pine knot extract from Pinus pinaster byproducts was characterized by UHPLC-DAD-MS and NMR. Fourteen polyphenols divided into four classes were identified as follows: lignans (nortrachelogenin, pinoresinol, matairesinol, isolariciresinol, secoisolariciresinol), flavonoids (pinocembrin, pinobanksin, dihydrokaempferol, taxifolin), stilbenes (pinosylvin, pinosylvin monomethyl ether, pterostilbene), a ...
DOI:: 10.1021/acs.jafc.7b04129
: https://doi.org/10.1021/acs.jafc.7b04129

58. Protective effects of petroleum ether extracts of Herpetospermum caudigerum against α-naphthylisothiocyanate-induced acute cholestasis of rats

Author:: Wen-rui Cao; Jing-qiu Ge; Xin Xie; Meng-lin Fan; Xu-dong Fan; Hong Wang; Zhao-yue Dong; Zhi-hua Liao; Xiao-zhong Lan; Min Chen
Source:: Journal of ethnopharmacology 2017 v.198 pp. 139-147
ISSN:: 0378-8741
Subject:: active ingredients; alanine transaminase; alkaline phosphatase; antioxidant activity; aspartate transaminase; bile; bile acids; bilirubin; blood serum; carbon tetrachloride; cholestasis; dose response; free radical scavengers; gas chromatography-mass spectrometry; glutathione transferase; hepatitis; histopathology; inflammation; jaundice; lignans; liver; long chain fatty acids; malondialdehyde; myeloperoxidase; nitric oxide; oral administration; oxidative stress; petroleum; protective effect; rats; seed oils; seeds; spectrometers; superoxide dismutase; traditional medicine
Abstract:: ... The ripe seeds of Herpetospermum caudigerum have been used in Tibetan folk medicine for treatment of bile or liver diseases including jaundice, hepatitis, intumescences or inflammation. Previously reports suggested that the seed oil and some lignans from H. caudigerum exhibited protective effects against carbon tetrachloride (CCl4)-induced hepatic damage in rats, which may be related to their free ...
DOI:: 10.1016/j.jep.2017.01.003
: https://doi.org/10.1016/j.jep.2017.01.003

59. RP‐HPLC‐DAD‐ESI‐QTOF‐MS based metabolic profiling of the potential Olea europaea by‐product “wood” and its comparison with leaf counterpart

Author:: Sonda Ammar; Maria del Mar Contreras; Boutheina Gargouri; Antonio Segura‐Carretero; Mohamed Bouaziz
Source:: Phytochemical analysis 2017 v.28 no.3 pp. 217-229
ISSN:: 0958-0344
Subject:: Olea europaea; aldehydes; bioactive compounds; bioactive properties; byproducts; chemical structure; coumarins; cultivars; flavonoids; high performance liquid chromatography; leaves; lignans; mass spectrometry; metabolites; metabolomics; olives; phenolic acids; phytopharmaceuticals; roots; secoiridoids; stems; sugars; trees; wood
Abstract:: ... INTRODUCTION: Olea europaea L. organs such as leaves, stems and roots have been associated with numerous in vivo and in vitro biological activities and used for traditional medicinal purposes. However, tree wood is an untapped resource with little information about their chemical composition. OBJECTIVE: That is why, the objective of this study is to increase the knowledge about phytochemicals from ...
DOI:: 10.1002/pca.2664
: https://doi.org/10.1002/pca.2664

60. Rapid purification of diastereoisomers from Piper kadsura using supercritical fluid chromatography with chiral stationary phases

Author:: Huaxia Xin; Zhuoshun Dai; Jianfeng Cai; Yanxiong Ke; Hui Shi; Qing Fu; Yu Jin; Xinmiao Liang
Source:: Journal of chromatography 2017 v.1509 pp. 141-146
ISSN:: 0021-9673
Subject:: Kadsura; Piper; diastereomers; lignans; methylene chloride; purification methods; solubility; supercritical fluid chromatography
Abstract:: ... Supercritical fluid chromatography (SFC) with chiral stationary phases (CSPs) is an advanced solution for the separation of achiral compounds in Piper kadsura. Analogues and stereoisomers are abundant in natural products, but there are obstacles in separation using conventional method. In this paper, four lignan diastereoisomers, (-)-Galbelgin, (-)-Ganschisandrin, Galgravin and (-)-Veraguensin, fr ...
DOI:: 10.1016/j.chroma.2017.06.020
: https://doi.org/10.1016/j.chroma.2017.06.020

61. Schisandra chinensis extract decreases chloroacetaldehyde production in rats and attenuates cyclophosphamide toxicity in liver, kidney and brain

Author:: Jianxiu Zhai; Feng zhang; Shouhong Gao; Li Chen; Ge Feng; Jun Yin; Wansheng Chen
Source:: Journal of ethnopharmacology 2017 pp. -
ISSN:: 0378-8741
Subject:: Schisandra chinensis; alternative medicine; aspartate transaminase; bioactive compounds; brain; chromium; cyclophosphamide; histology; kidneys; lignans; liver; metabolites; oxidative stress; pharmacokinetics; protective effect; rats; toxicity; traditional medicine; urinary tract diseases; China
Abstract:: ... Schisandra chinensis (Turcz.) Baill (S. chinensis) has been used for thousands years in China, and is usually applied in treatment of urinary tract disorders and liver injury. S. chinensis extract (SCE) has board protective effects on liver, kidney and nervous system. Schisandra lignans are generally considered as the bioactive components of SCE.To investigate the pharmacokinetic herb-drug interac ...
DOI:: 10.1016/j.jep.2017.08.020
: https://doi.org/10.1016/j.jep.2017.08.020

62. Sesame (Sesamum indicum L.), an underexploited oil seed crop: Current status, features and importance-A review

Author:: Khanin Pathak; Syed Wasifur Rahman; Sudhansu Bhagawati; Bhabesh Gogoi
Source:: Agricultural reviews 2017 v.38 no.3 pp. 223-227
ISSN:: 0976-0741
Subject:: Sesamum indicum; active ingredients; antibiotics; antihypertensive effect; antioxidant activity; antioxidants; antiseptics; biofuels; dietary minerals; disinfectants; health foods; lignans; lipid content; moths; nutrient content; nutrients; oilseed crops; polyunsaturated fatty acids; protein content; proteins; seed oils; sesame seed; tocopherols; tropics
Abstract:: ... Sesame is important oilseed crop of tropical and sub tropical region, renowned for its high oil content (up to 60% oil), hence sesame is known as the king of oil seeds. Sesame seed oil contains 83%-90% unsaturated fatty acids, 20% proteins and various minor nutrients such as vitamins and minerals, large amount of characteristic lignans, such as sesamin, sesamol, sesamolin and tocopherols. Sesame s ...
DOI:: 10.18805/ag.v38i03.8982
: https://doi.org/10.18805/ag.v38i03.8982

63. Seven new lignan glycosides from the branches of Alangium kurzii Craib var. laxifolium

Author:: Jie Ren; Yang-guo Xie; Ying-ying Huang; Sheng-lan Zhu; Shi-kai Yan; Hui-zi Jin; Wei-dong Zhang
Source:: Fitoterapia 2017 pp. -
ISSN:: 0367-326X
Subject:: Aeromonas hydrophila; Alangium; Enterococcus faecalis; Escherichia coli; Klebsiella pneumoniae; Pseudomonas aeruginosa; Salmonella Gallinarum; Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus agalactiae; Streptococcus suis; Vibrio parahaemolyticus; X-radiation; antibacterial properties; branches; circular dichroism spectroscopy; glycosides; lignans; medicinal plants; minimum inhibitory concentration; spectral analysis
Abstract:: ... Seven new lignan glycosides (1–3, 8–10, and 14) and 17 known compounds were isolated from the branches of Alangium kurzii Craib var. laxifolium. Their structures were established by spectroscopic analysis and circular dichroism (CD) and X-ray analysis. The isolated compounds were evaluated for their antibacterial activities against Staphylococcus aureus CI1011, Streptococcus suis CI1608, Salmonell ...
DOI:: 10.1016/j.fitote.2017.07.009
: https://doi.org/10.1016/j.fitote.2017.07.009

64. Studies on non-phenolic lignans in alkaline cooking

Author:: Bill Mangindaan; Yasuyuki Matsushita; Dan Aoki; Sachie Yagami; Kazuhiko Fukushima
Source:: Holzforschung 2017 v.71 no.12 pp. 961-967
ISSN:: 1437-434X
Subject:: acidity; bleaching; carbon; chemical reactions; color; cooking; isotope labeling; lignans; moieties; pulp; reaction mechanisms; stable isotopes; temperature; vanillin
Abstract:: ... The stability and chemical reactions of lignans during alkaline cooking is not yet fully clarified although their degradation products may have a considerable effect on the pulp and its bleaching, such as spotting and color contamination. To fill this gap, a phenolic lignan (pinoresinol) and four non-phenolic furofuran lignans (gmelinol, paulownin, eudesmin and sesamin) were submitted to alkaline ...
DOI:: 10.1515/hf-2017-0056
: https://doi.org/10.1515/hf-2017-0056

65. The Contents of Lignans in Sesame Seeds and Commercial Sesame Oils of China

Author:: Long-Kai Shi; Rui-Jie Liu; Qing-Zhe Jin; Xing-Guo Wang
Source:: The journal of the American Oil Chemists' Society 2017 v.94 no.8 pp. 1035-1044
ISSN:: 0003-021X
Subject:: high performance liquid chromatography; lignans; seeds; sesame oil; sesame seed; China
Abstract:: ... In this study, the concentrations of three lignans in 100 sesame seeds and 56 sesame oils were determined using a newly developed method based on high-performance liquid chromatography coupled with a UV/Vis detector. Total lignan contents in sesame seed and oil samples ranged from 2.52 to 12.76 and 3.38 to 11.53 mg/g, respectively. Black sesame seeds showed higher sesamin content (range 1.98–9.41 ...
DOI:: 10.1007/s11746-017-3018-7
: https://doi.org/10.1007/s11746-017-3018-7

66. The lignan (+)‐secoisolariciresinol extracted from flax hulls is an effective protectant of linseed oil and its emulsion against oxidative damage

Author:: Christophe Hano; Cyrielle Corbin; Samantha Drouet; Anthony Quéro; Natacha Rombaut; Raphaëlle Savoire; Roland Molinié; Brigitte Thomasset; François Mesnard; Eric Lainé
Source:: European journal of lipid science and technology 2017 v.119 no.8 pp. -
ISSN:: 1438-7697
Subject:: alpha-tocopherol; antioxidants; butylated hydroxyanisole; cosmetics; emulsions; flax; functional foods; hulls; human health; lignans; linseed cake; linseed oil; oxidation; pressing; protective effect; seed coat; thiobarbituric acid-reactive substances
Abstract:: ... Secoisolariciresinol (SECO) is a natural antioxidant lignan accumulated in large amounts in the seedcoat of flax and retained in the flaxseed cake residue during linseed oil pressing. Here SECO was extracted and purified from flaxseed cake and assayed for its ability to prevent oxidation of linseed oil and an o/w emulsion containing linseed oil. For this purpose, an accelerated storage (Schaal ove ...
DOI:: 10.1002/ejlt.201600219
: https://doi.org/10.1002/ejlt.201600219

67. Three new iridoid glycosides isolated from the traditional herb Siphonostegia chinensis with NF-κB inhibitory activity

Author:: Jiao-xian Cao; Rui An; Ying Tang; Han-chuan Yu; Ying-chun Wu; Xin-Hong Wang
Source:: Phytochemistry letters 2017 v.22 pp. 261-265
ISSN:: 1874-3900
Subject:: chemotaxonomy; iridoid glycosides; lignans; mass spectrometry; nuclear magnetic resonance spectroscopy; transcription factor NF-kappa B
Abstract:: ... Siphonoids A–C (1–3), among which siphonoids A-B (1–2) are rare (E)-p-coumaroyl iridoids, were isolated from Siphonostegia chinensis along with ten known iridoids (4–13) and four lignans (14–17). The structures of the compounds were established by 1D- and 2D-NMR spectroscopy and mass spectrometry. Most of the iridoids isolated from S. chinensis were found to possess (E)-p-coumaroyl iridoid subtype ...
DOI:: 10.1016/j.phytol.2017.10.022
: https://doi.org/10.1016/j.phytol.2017.10.022

68. Trends in accumulation of pharmacologically important antioxidant-secondary metabolites in callus cultures of Linum usitatissimum L.

Author:: Sumaira Anjum; Bilal Haider Abbasi; Christophe Hano
Source:: Plant cell, tissue, and organ culture 2017 v.129 no.1 pp. 73-87
ISSN:: 0167-6857
Subject:: Linum usitatissimum; alcohols; antioxidant activity; benzyladenine; biomass; callus; callus culture; explants; flavonoids; flax; glucosides; high performance liquid chromatography; human health; leaves; lignans; naphthaleneacetic acid; neoplasms; secondary metabolites; thidiazuron
Abstract:: ... Linum usitatissimum: L. is well-known for production of pharmacologically important secondary metabolites. Due to their tremendous beneficial effects on human health, these compounds are receiving greater attention throughout the World, especially in the treatment of various types of cancers. In present study, we have developed an efficient protocol for production of lignans like secoisolariciresi ...
DOI:: 10.1007/s11240-016-1158-3
: https://doi.org/10.1007/s11240-016-1158-3

69. Two new lignans from Saururus chinensis

Author:: Cuibai Li; Ningxin Li; Jiarui Yue; Qishi Song; Qingfei Fan
Source:: Natural product research 2017 v.31 no.14 pp. 1598-1603
ISSN:: 1478-6427
Subject:: Saururus chinensis; antineoplastic activity; cytotoxicity; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:: ... Two new lignans, (Z)-14-bis(3′,4′-dimethoxyphenyl)-2,3-dimethylbut-2-ene-1,4-dione (1), threo -2-methyl-3-oxo-1-(3′,4′,5′-trimethoxyphenyl)butyl-3″,4″-dimethoxybenzoate (2), together with 15 known derivatives (3 – 17) were isolated from Saururus chinensis . Their structures were determined on the basis of spectral data, including 1D and 2D NMR experiments and HREIMS spectra. The antitumour activit ...
DOI:: 10.1080/14786419.2017.1286483
: https://doi.org/10.1080/14786419.2017.1286483

70. Using connectivity map to identify natural lignan justicidin A as a NF-κB suppressor

Author:: Shen-Jeu Won; Cheng-Hsin Yen; Hao-Wen Hsieh; Shao-Wei Chang; Chun-Nan Lin; Chi-Ying F. Huang; Chun-Li Su
Source:: Journal of functional foods 2017 v.34 pp. 68-76
ISSN:: 1756-4646
Subject:: Justicia procumbens; Oriental traditional medicine; apoptosis; chemical elements; colorectal neoplasms; cytotoxicity; gene expression; hepatoma; humans; lignans; mitochondria; phosphorylation; phytopharmaceuticals; prostaglandins; transcription factor NF-kappa B; China; Taiwan
Abstract:: ... Justicidin A (JA), a natural lignan, was isolated from the whole plant of Justicia procumbens, one of the most popular traditional Chinese medicines in China and Taiwan. Gene expression signatures of JA from human colorectal cancer HT-29 and hepatocellular carcinoma Hep 3B cells were used to query connectivity map. A NF-κB suppressor (15-delta prostaglandin J2) was predicted to display similar mol ...
DOI:: 10.1016/j.jff.2017.04.017
: https://doi.org/10.1016/j.jff.2017.04.017

71. (-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1

Author:: Di Yang; Chen-Xi Xiao; Zheng-Hua Su; Meng-Wei Huang; Ming Qin; Wei-Jun Wu; Wan-Wan Jia; Yi-Zhun Zhu; Jin-Feng Hu; Xin-Hua Liu
Source:: Phytomedicine 2017 v.32 pp. 15-23
ISSN:: 0944-7113
Subject:: Western blotting; anti-inflammatory activity; antineoplastic activity; antioxidants; cardiovascular diseases; drugs; endothelial cells; fluorescent antibody technique; gene expression regulation; heme oxygenase (biliverdin-producing); inducible nitric oxide synthase; inflammation; interleukin-6; lignans; messenger RNA; mitogen-activated protein kinase; necrosis; pathogenesis; phosphorylation; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; superoxide dismutase; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Endothelial inflammation is an increasingly prevalent condition in the pathogenesis of many cardiovascular diseases. (-)-7(S)-hydroxymatairesinol (7-HMR), a naturally occurring plant lignan, possesses both antioxidant and anti-cancer properties and therefore would be a good strategy to suppress tumor necrosis factor-α (TNF-α)-mediated inflammation in vascular endothelial cells (VECs).: The objecti ...
DOI:: 10.1016/j.phymed.2017.04.005
: https://doi.org/10.1016/j.phymed.2017.04.005

72. A New Insecticidal Lignan Glucoside from Galium verum

Author:: Jia Chen; Chun-Chao Zhao; Jian-Hua Shao; Ju-Di Fan; Xu-Hua Huang
Source:: Chemistry of natural compounds 2017 v.53 no.4 pp. 626-628
ISSN:: 0009-3130
Subject:: Galium verum; Helicoverpa armigera; Scorpiones; chemical structure; glucosides; insecticidal properties; lignans; mortality; poisoning; scorpion venoms; spectral analysis; stomach; toxicity
Abstract:: ... A new lignan glucoside, galiveroside A (1), and seven known compounds (2–8), were isolated from Galium verum L. The structure of 1 was elucidated on the basis of extensive spectroscopic analyses. Compound 1, at the concentration of 5 mg/mL, showed insecticide activity to 3 age cotton bollworm with a mortality of 16.3% through stomach poisoning. When combined with a recombinant scorpion toxin rLqh ...
DOI:: 10.1007/s10600-017-2075-3
: https://doi.org/10.1007/s10600-017-2075-3

73. A New Lignan Glucoside from Cyclea racemosa

Author:: Jian-Hua Shao; Xue-Wei Zhang; Zi-Ling Dong; Si-Hui Li; Ben-Jie Miao; Ke-Zhi Cheng
Source:: Chemistry of natural compounds 2017 v.53 no.6 pp. 1025-1027
ISSN:: 0009-3130
Subject:: Cyclea; chemical structure; glucosides; lignans; spectral analysis
Abstract:: ... A new lignan glucoside 1, along with two known lignans (2, 3), was isolated from Cyclea racemosa Oliv. Its structure was elucidated as (+)-7′-methoxylariciresinol 4-O-β-D-glucopyranoside on the basis of extensive spectroscopic analyses. ...
DOI:: 10.1007/s10600-017-2193-y
: https://doi.org/10.1007/s10600-017-2193-y

74. A new cyclopeptide and a new lignan from Podocarpus neriifolius

Author:: Jingjing Wu; Haoliang Li; Guoli Huang; Yegao Chen
Source:: Natural product research 2017 v.31 no.2 pp. 239-244
ISSN:: 1478-6427
Subject:: Podocarpus neriifolius; diterpenoids; leaves; lignans; mass spectrometry; nuclear magnetic resonance spectroscopy; sesquiterpenoids
Abstract:: ... A new cyclopeptide, neriitide A (1) and a new lignan, neriilignan (2), along with six known compounds including two diterpenoids, three sesquiterpenoids and one sterol were isolated from the leaves of Podocarpus neriifolius . Their structures were elucidated by means of extensive spectroscopic analysis including HREIMS, 1D and 2D NMR techniques. This is the first report of cyclopeptide and lignan ...
DOI:: 10.1080/14786419.2016.1226829
: https://doi.org/10.1080/14786419.2016.1226829

75. A new lignan glycoside from the stems of Zanthoxylum armatum DC

Author:: Tao Guo; Xiao-Feng Tang; Jun Chang; Ya Wang
Source:: Natural product research 2017 v.31 no.1 pp. 16-21
ISSN:: 1478-6427
Subject:: Zanthoxylum armatum; glycosides; lignans; phenylpropanoids; spectroscopy; stems
Abstract:: ... A new lignan glycoside, (7S , 8R)-guaiacylglycerol-ferulic acid ether-7-O- β -D-glucopyranoside (1), along with five known phenylpropanoids (2 – 6) and seven phenylpropanoid glycosides (7 – 13), were isolated from the stems of Zanthoxylum armatum DC. Their structures were elucidated by spectroscopic analysis. Compounds 2 – 8 and 11 – 13 were first isolated from Rutaceae and the others were isolate ...
DOI:: 10.1080/14786419.2016.1205064
: https://doi.org/10.1080/14786419.2016.1205064

76. A new neolignan from Selaginella moellendorffii Hieron

Author:: Wei Zeng; Cai-Ping Yao; Ping-Sheng Xu; Guo-Gang Zhang; Zhao-Qian Liu; Kang-Ping Xu; Zhen-Xing Zou; Gui-Shan Tan
Source:: Natural product research 2017 v.31 no.19 pp. 2223-2227
ISSN:: 1478-6427
Subject:: Selaginella; human umbilical vein endothelial cells; lignans; nuclear magnetic resonance spectroscopy; protective effect
Abstract:: ... A new neolignan, selamoellenin A (1), was isolated from the whole plants of Selaginella moellendorffii Hieron. The structure was elucidated on the basis of comprehensive spectroscopic methods (1D/2D NMR and HRMS). Compound 1 was evaluated for its protective effect against high glucose-induced human umbilical vein endothelial cells (HUVECs) damage in vitro. ...
DOI:: 10.1080/14786419.2017.1297935
: https://doi.org/10.1080/14786419.2017.1297935

77. A sensitive UHPLC–MS/MS method for the simultaneous quantification of three lignans in human plasma and its application to a pharmacokinetic study

Author:: Sook‐Jin Kim; Hwajin Shin; Seong‐Moon Cheon; Se‐mi Ko; Seong‐Ho Ham; Young‐Dal Kwon; Yong‐Bok Lee; Hea‐Young Cho
Source:: Journal of separation science 2017 v.40 no.17 pp. 3430-3439
ISSN:: 1615-9306
Subject:: acetic acid; acetonitrile; correlation; humans; lignans; liquid-liquid extraction; monitoring; oral administration; pharmacokinetics; tandem mass spectrometry; ultra-performance liquid chromatography
Abstract:: ... The aim of this study was to develop an analytical method to simultaneously analyze schizandrin, schizandrol B, and gomisin N lignans in human plasma using ultra high performance liquid chromatography with tandem mass spectrometry. The three lignans were separated using a mobile phase of water and acetonitrile containing 0.02% acetic acid equipped with a Kinetex C₁₈ column (2.1 mm × 50 mm, 1.7 μm) ...
DOI:: 10.1002/jssc.201700588
: https://doi.org/10.1002/jssc.201700588

78. Alashinols F and G, two lignans from stem bark of Syringa pinnatifolia

Author:: Xiao Feng; Guozhu Su; Yunyun Ye; Ruifei Zhang; Xinyao Yang; Bingzhao Du; Bing Peng; Pengfei Tu; Xingyun Chai
Source:: Natural product research 2017 v.31 no.13 pp. 1555-1560
ISSN:: 1478-6427
Subject:: Syringa; anti-inflammatory activity; bark; lignans; nuclear magnetic resonance spectroscopy; spectral analysis; traditional medicine
Abstract:: ... Two new lignans, alashinols F and G (1 and 2), together with two known analogues (−)-secoisolariciresinol (3) and meso -secoisolariciresinol (4) were isolated from the stem bark of Syringa pinnatifolia , a Mongolian folk medicine with anti-myocardial ischaemic effects. Their structures were elucidated on basis of spectroscopic data analyses, including MS and 1D and 2D NMR, and their absolute confi ...
DOI:: 10.1080/14786419.2017.1283500
: https://doi.org/10.1080/14786419.2017.1283500

79. Almond Polyphenols: Methods of Analysis, Contribution to Food Quality, and Health Promotion

Author:: Bradley W. Bolling
Source:: Comprehensive reviews in food science and food safety 2017 v.16 no.3 pp. 346-368
ISSN:: 1541-4337
Subject:: aldehydes; almonds; antioxidant activity; antioxidants; antiviral properties; astringency; blanching; food quality; health promotion; hydrolysis; ingredients; isoflavones; lignans; lipid composition; lipid peroxidation; pasteurization; pigmentation; proanthocyanidins; roasting; shelf life; solvents; stilbenes; tannins; ultraviolet radiation; vitamin E
Abstract:: ... Almond is a nutrient‐dense tree nut recognized for its favorable lipid profile, vitamin E content, and polyphenols. The objectives of this review were to determine the polyphenols reported in almond, summarize the methods of analysis, and determine the polyphenol contribution to almond quality and health‐promoting activity. Approximately 130 different polyphenols have been identified in almond, al ...
DOI:: 10.1111/1541-4337.12260
: https://doi.org/10.1111/1541-4337.12260

80. An insight into anti-diabetic properties of dietary phytochemicals

Author:: Ramachandran Vinayagam; Jianbo Xiao; Baojun Xu
Source:: Phytochemistry reviews 2017 v.16 no.3 pp. 535-553
ISSN:: 1568-7767
Subject:: alkaloids; alpha-amylase; antioxidant activity; blood glucose; coumarins; diabetes mellitus; disease control; flavonoids; foods; glucose; glycemic effect; glycogenesis; glycolysis; human diseases; insulin resistance; insulin secretion; intestinal absorption; islets of Langerhans; lignans; mechanism of action; monoterpenoids; phytopharmaceuticals; stilbenes
Abstract:: ... Diabetes are a serious metabolic diseases characterized by abnormally increased plasma glucose levels. Botanical food products have been used for combating human diseases for thousands of years, since they exhibit a wide range of biological properties that can be exploited for medical application. Phytochemicals from foods, including flavonoids, monoterpenes, terpenoids, stilbenes, lignans, coumar ...
DOI:: 10.1007/s11101-017-9496-2
: https://doi.org/10.1007/s11101-017-9496-2

81. Anti-biofilm activity against Staphylococcus aureus MRSA and MSSA of neolignans and extract of Piper regnellii

Author:: Lara Z.S. Brambilla; Eliana H. Endo; Diógenes A.G. Cortez; Benedito P. Dias Filho
Source:: Revista Brasileira de Farmacognosia 2017 v.27 no.1 pp. 112-117
ISSN:: 0102-695X
Subject:: Piper; antibiotic resistance; antimicrobial properties; biofilm; disease control; lignans; methicillin; methicillin-resistant Staphylococcus aureus; methylene chloride; minimum inhibitory concentration; plankton
Abstract:: ... Many infections worldwide are associated with bacterial biofilms. The effects of isolated neolignans (conocarpan and eupomathenoid-5) and the dichloromethane extract of Piper regnellii (Miq.) C. DC., Piperaceae, were tested against isolates of methicillin-resistant Staphylococcus aureus and methicillin-sensitive S. aureus biofilms and S. aureus planktonic cells. The dichloromethane extract present ...
DOI:: 10.1016/j.bjp.2016.08.008
: https://doi.org/10.1016/j.bjp.2016.08.008

82. Anti-inflammatory effects of Forsythia suspensa in dextran sulfate sodium-induced colitis

Author:: Youn-Hwan Hwang; Dong-Gun Kim; Wei Li; Hye Jin Yang; Nam-Hui Yim; Jin Yeul Ma
Source:: Journal of ethnopharmacology 2017 v.206 pp. 73-77
ISSN:: 0378-8741
Subject:: Forsythia suspensa; Oriental traditional medicine; anti-inflammatory activity; body weight changes; colitis; colon; dextran sulfate; diarrhea; edema; epithelium; flavonoids; histopathology; inflammation; interleukin-6; lignans; necrosis; therapeutics; triterpenoids; tumor necrosis factor-alpha
Abstract:: ... Forsythia suspensa Fructus (FS) is used to treat various inflammatory disorders in traditional Oriental medicine, including gastrointestinal diseases, but its therapeutic potential in ulcerative colitis is unclear. Thus, we investigated any potential therapeutic effects of FS against intestinal inflammation and the bioactive constituents in FS.After the induction of colitis using 3% dextran sulfat ...
DOI:: 10.1016/j.jep.2017.05.011
: https://doi.org/10.1016/j.jep.2017.05.011

83. Anti-neuroinflammatory asarone derivatives from the rhizomes of Acorus tatarinowii

Author:: Da-Peng Qin; Xiao-Lin Feng; Wei-Yang Zhang; Hao Gao; Xiao-Rui Cheng; Wen-Xia Zhou; Yang Yu; Xin-Sheng Yao
Source:: RSC advances 2017 v.7 no.14 pp. 8512-8520
ISSN:: 2046-2069
Subject:: Acorus gramineus; X-ray diffraction; cell lines; cytotoxicity; enantiomers; lignans; mice; neuroglia; rhizomes; spectroscopy; tumor necrosis factor-alpha
Abstract:: ... A novel 7-O-7′ type mesomeric neolignan, meso-asarolignan A (1), six pairs of new neolignan enantiomers, (±)-asarolignan B–G (2a/2b, 3a/3b, 4–6, 7a/7b), along with 16 known analogues (8–23) were isolated from the rhizomes of Acorus tatarinowii. The structures of the new compounds were elucidated by extensive analysis of spectroscopic, X-ray diffraction, and computational data. Compounds 1–3 repres ...
DOI:: 10.1039/c6ra27786a
: https://doi.org/10.1039/c6ra27786a

84. Antidiabetic effect of gomisin N via activation of AMP-activated protein kinase

Author:: Dae Young Jung; Ji-Hyun Kim; Hoyoung Lee; Myeong Ho Jung
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: AMP-activated protein kinase; Schisandra chinensis; animal disease models; beta oxidation; biogenesis; blood glucose; fatty liver; genes; glucose; glucose tolerance; glucose transporters; glycemic effect; high fat diet; in vivo studies; insulin; lignans; metabolic syndrome; mice; mitochondria; myotubes; obesity; phosphorylation; plasma membrane; skeletal muscle
Abstract:: ... Gomisin N (GN) is a lignan derived from Schisandra chinensis. AMP-activated kinase (AMPK) has gained attention as a therapeutic target for the treatment of metabolic syndrome. Previously, we reported that GN activated the AMPK pathway and ameliorated high-fat diet (HFD)-induced hepatic steatosis. In this study, we investigated the anti-diabetic effects of GN in C2C12 myotubes and HFD obese mice. G ...
DOI:: 10.1016/j.bbrc.2017.10.120
: https://doi.org/10.1016/j.bbrc.2017.10.120

85. Antioxidant and antimicrobial activity of linseed lignans and phenolic acids

Author:: Jan Kyselka; Dobrochna Rabiej; Miroslav Dragoun; František Kreps; Zuzana Burčová; Irena Němečková; Jana Smolová; Marie Bjelková; Aleksandra Szydłowska-Czerniak; Štefan Schmidt; Luděk Šarman; Vladimír Filip
Source:: European food research & technology 2017 v.243 no.9 pp. 1633-1644
ISSN:: 1438-2377
Subject:: Gram-negative bacteria; Gram-positive bacteria; antimicrobial properties; antioxidants; bioactive compounds; caffeic acid; chromatography; ferulic acid; hydrolysis; levulinic acid; lignans; linseed; lipid peroxidation; mass spectrometry; median effective concentration; molds (fungi); oxidation; p-coumaric acid; pressing; reaction kinetics; secondary metabolites; solvents; stoichiometry; triacylglycerols; yeasts
Abstract:: ... In this study, we present antioxidant and antimicrobial activity of isolated lignans freed of other bioactive compounds in comparison with dominant phenolic acids. The combinations of screw pressing, solvent extractions, acid-catalysed hydrolysis and flash chromatography were used to describe and isolate linseed phenolic compounds. Secoisolariciresinol, ferulic, p-coumaric and caffeic acids were t ...
DOI:: 10.1007/s00217-017-2871-9
: https://doi.org/10.1007/s00217-017-2871-9

86. Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome

Author:: Shimeng Zhang; Liangjun Jiang; Fengyuan Che; Yucheng Lu; Zhongxiang Xie; Hao Wang
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: Arctium lappa; brain; infarction; inflammasomes; interleukin-18; interleukin-1beta; ischemia; lignans; neuroprotective effect; protein synthesis; rats; secretion; signal transduction; stroke; surgery; water content
Abstract:: ... Arctigenin (ARC), a phenylpropanoid dibenzylbutyrolactone lignan derived from Arctium lappa L, has been reported to protect against cerebral ischemia injury in rats, but the underlying mechanism is unclear. In this study, we investigated whether ARC ameliorated ischemic stroke by inhibiting NLRP3 inflammasome-derived neuroinflammation and whether SIRT1 signaling was involved in this process. ARC ( ...
DOI:: 10.1016/j.bbrc.2017.08.062
: https://doi.org/10.1016/j.bbrc.2017.08.062

87. Arctigenin suppresses renal interstitial fibrosis in a rat model of obstructive nephropathy

Author:: Ao Li; Xiaoxun Zhang; Mao Shu; Mingjun Wu; Jun Wang; Jingyao Zhang; Rui Wang; Peng Li; Yitao Wang
Source:: Phytomedicine 2017 v.30 pp. 28-41
ISSN:: 0944-7113
Subject:: Arctium lappa; animal disease models; anti-inflammatory activity; antioxidant activity; atrophy; chemokine CCL2; collagen; disease prevention; epithelium; fibrosis; fruits; furans; histology; inflammation; interferon-gamma; interleukin-1beta; kidney diseases; lignans; lipid peroxidation; macrophages; messenger RNA; oxidative stress; phytopharmaceuticals; protein phosphorylation; rats; renal tubules; renoprotective effect; superoxide dismutase; transcription factor NF-kappa B; transforming growth factor beta 1; tumor necrosis factor-alpha
Abstract:: ... Renal tubulointerstitial fibrosis (TIF) is commonly the final result of a variety of progressive injuries and leads to end-stage renal disease. There are few therapeutic agents currently available for retarding the development of renal TIF.The aim of the present study is to evaluate the role of arctigenin (ATG), a lignan component derived from dried burdock (Arctium lappa L.) fruits, in protecting ...
DOI:: 10.1016/j.phymed.2017.03.003
: https://doi.org/10.1016/j.phymed.2017.03.003

88. Association between Urinary Phytoestrogens and C-reactive Protein in the Continuous National Health and Nutrition Examination Survey

Author:: Michael K. Reger; Terrell W. Zollinger; Ziyue Liu; Josette Jones; Jianjun Zhang
Source:: Journal of the American College of Nutrition 2017 v.36 no.6 pp. 434-441
ISSN:: 1541-1087
Subject:: C-reactive protein; National Health and Nutrition Examination Survey; biomarkers; blood serum; cardiovascular diseases; confidence interval; inflammation; lignans; neoplasms; plant estrogens; risk; risk reduction; United States
Abstract:: ... Objective : A reduced risk of some cancers and cardiovascular disease associated with phytoestrogen intake may be mediated through its effect on serum C-reactive protein (CRP; an inflammation biomarker). Therefore, this study examined the associations between urinary phytoestrogens and serum CRP. Methods : Urinary phytoestrogen and serum CRP data obtained from 6009 participants aged ≥ 40 years in ...
DOI:: 10.1080/07315724.2017.1318722
: https://doi.org/10.1080/07315724.2017.1318722

89. Association between polyphenol intake and adherence to the Mediterranean diet in Sicily, southern Italy

Author:: Justyna Godos; Giuseppina Rapisarda; Stefano Marventano; Fabio Galvano; Antonio Mistretta; Giuseppe Grosso
Source:: NFS journal 2017 v.8 pp. 1-7
ISSN:: 2352-3646
Subject:: Mediterranean diet; adults; anthocyanins; apigenin; databases; dietary nutrient sources; eating habits; ferulic acid; food intake; hesperetin; lignans; matairesinol; myricetin; naringenin; polyphenols; questionnaires; regression analysis; traditional foods; urban areas; Italy; Sicily
Abstract:: ... Mediterranean diet has been demonstrated to exert beneficial effects toward various health outcomes. Among the compounds that may be responsible for such benefits, polyphenols have been proposed as potential candidates. The aim of this study was to evaluate whether dietary polyphenols were associated with adherence to the Mediterranean diet in a Sicilian cohort.A total of 1937 adults were recruite ...
DOI:: 10.1016/j.nfs.2017.06.001
: https://doi.org/10.1016/j.nfs.2017.06.001

90. Associations between Both Lignan and Yogurt Consumption and Cardiovascular Risk Parameters in an Elderly Population: Observations from a Cross-Sectional Approach in the PREDIMED Study

Author:: Anna Creus-Cuadros; Anna Tresserra-Rimbau; Paola Quifer-Rada; Miguel Angel Martínez-González; Dolores Corella; Jordi Salas-Salvadó; Montse Fitó; Ramon Estruch; Enrique Gómez-Gracia; José Lapetra; Fernando Arós; Miquel Fiol; Emili Ros; Lluís Serra-Majem; Xavier Pintó; Juan José Moreno; Miguel Ruiz-Canela; Jose Vicente Sorli; Josep Basora; Helmut Schröder; Rosa Maria Lamuela-Raventós; PREDIMED Study Investigators
Source:: Journal of the Academy of Nutrition and Dietetics 2017 v.117 no.4 pp. 609-622.e1
ISSN:: 2212-2672
Subject:: biomarkers; blood pressure; body mass index; cardiovascular diseases; cross-sectional studies; dairy consumption; diet study techniques; eating habits; elderly; glucose; human health; lignans; linear models; low density lipoprotein cholesterol; men; risk; triacylglycerols; waist circumference; women; yogurt
Abstract:: ... The study of dietary patterns is gaining interest. Although the health benefits of yogurt and lignans have been investigated separately, to our knowledge there are no studies on their associative effects.The aim of this study was to evaluate a possible association between yogurt and lignans using biomarkers of cardiovascular disease risk in an elderly population.We conducted a cross-sectional anal ...
DOI:: 10.1016/j.jand.2016.11.003
: https://doi.org/10.1016/j.jand.2016.11.003

91. Asymmetric synthesis of furofurans

Author:: Manat Pohmakotr; Chutima Kuhakarn; Vichai Reutrakul; Darunee Soorukram
Source:: Tetrahedron letters 2017 pp. -
ISSN:: 0040-4039
Subject:: bioactive properties; chemical reactions; chemical structure; lignans; stereochemistry; stereoselectivity
Abstract:: ... Furofurans are one of the largest sub-types of classical lignans which have been found to possess a broad range of important biological activities. Tremendous efforts have been directed to develop synthetic methodologies for the synthesis of furofurans, especially in a stereoselective manner, due to their interesting bioactivities associated with the structural and stereochemical complexity. This ...
DOI:: 10.1016/j.tetlet.2017.11.011
: https://doi.org/10.1016/j.tetlet.2017.11.011

92. Bioactive Asarone-Derived Phenylpropanoids from the Rhizome of Acorus tatarinowii Schott

Author:: Gao En; Zhou Zheng-Qun; Zou Jian; Yu Yang; Feng Xiao-Lin; Chen Guo-Dong; He Rong-Rong; Yao Xin-Sheng; Gao Hao
Source:: Journal of natural products 2017 v.80 no.11 pp. 2923-2929
ISSN:: 1520-6025
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Acorus gramineus; acarbose; acetylcholinesterase; alpha-glucosidase; antioxidant activity; antioxidants; benzene; drugs; enantiomers; enzyme inhibition; high performance liquid chromatography; inhibitory concentration 50; lignans; phenylpropanoids; rhizomes; spectral analysis
Abstract:: ... Eight new (1a/1b, 2a, 3a, 4a/4b, and 5a/5b) and seven known (2b, 3b, and 6–10) asarone-derived phenylpropanoids, a known asarone-derived lignan (12), and four known lignan analogues (11 and 13–15) were isolated from the rhizome of Acorus tatarinowii Schott. The structures were elucidated via comprehensive spectroscopic analyses, modified Mosher’s method, and quantum chemical calculations. Compound ...
DOI:: 10.1021/acs.jnatprod.7b00457
: https://doi.org/10.1021/acs.jnatprod.7b00457

93. Bioactive Glycosides from the Twigs of Litsea cubeba

Author:: Wang Ling-Yan; Chen Ming-Hua; Wu Jiang; Sun Hua; Liu Wei; Qu Yu-Hong; Li Yan-Cheng; Wu Yu-Zhuo; Li Rui; Zhang Dan; Wang Su-Juan; Lin Sheng
Source:: Journal of natural products 2017 v.80 no.6 pp. 1808-1818
ISSN:: 1520-6025
Subject:: Litsea cubeba; X-ray diffraction; air drying; branches; circular dichroism spectroscopy; glucosides; human cell lines; inhibitory concentration 50; lignans; medicinal plants; nuclear magnetic resonance spectroscopy
Abstract:: ... The air-dried twigs of Litsea cubeba, a traditional Chinese medicinal tree, afforded 10 new aromatic glycosides (1–10) and 26 known analogues. Their structures were assigned by extensive 1D and 2D NMR experiments, and the absolute configurations were resolved by chemical methods, electronic circular dichroism, specific rotation, and X-ray crystallographic analysis. Compound 4 is the first example ...
DOI:: 10.1021/acs.jnatprod.6b01189
: https://doi.org/10.1021/acs.jnatprod.6b01189

94. Bioactive lignans from the stems of Mappianthus iodoides

Author:: Zhi-Hua Jiang; Ling Chai; Yan-Ping Liu; Hong-Cong Qiu; Ting-Ting Wang; Xing-Yang Feng; Yi-Tong Wang; Ze-Hao Huang; Bu-Ming Liu; Yan-Hui Fu
Source:: Phytochemistry letters 2017 v.22 pp. 194-198
ISSN:: 1874-3900
Subject:: anti-inflammatory activity; cortisol; inhibitory concentration 50; lignans; lipopolysaccharides; macrophages; mice; nitric oxide; spectroscopy; stems
Abstract:: ... Two new lignans, mappianthines A (1) and B (2), along with ten known analogues (3-12), were isolated from the stems of Mappianthus iodoides. The structures with the absolute configurations of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literatures. All new compounds were evaluated for their ...
DOI:: 10.1016/j.phytol.2017.10.012
: https://doi.org/10.1016/j.phytol.2017.10.012

95. Bioactive phenolics from in vitro cultures of Lactuca aculeata Boiss. et Kotschy

Author:: Anna Stojakowska; Janusz Malarz
Source:: Phytochemistry letters 2017 v.19 pp. 7-11
ISSN:: 1874-3900
Subject:: Lactuca; caffeic acid; callus culture; chlorogenic acid; glucosides; lignans; sesquiterpenoid lactones
Abstract:: ... A callus culture of Lactuca aculeata, except for commonly distributed caffeic acid derivatives typically found in the Asteraceae family (chlorogenic acid, methyl caffeate, 1,5- dicaffeoylquinic acid), yielded bioactive lignans: (+)-5-methoxybalanophonin, syringaresinol, (+)-balanophonin-9-O-β-glucopyranoside, (+) buddlenol A, (−)-dihydrodehydrodiconiferyl alcohol-4-O-β-glucopyranoside and (−)-dihy ...
DOI:: 10.1016/j.phytol.2016.11.003
: https://doi.org/10.1016/j.phytol.2016.11.003

96. Bioactive phytochemicals in barley

Author:: Emmanuel Idehen; Yao Tang; Shengmin Sang
Source:: Yàowù shípǐn fēnxī 2017 v.25 no.1 pp. 148-161
ISSN:: 1021-9498
Subject:: antioxidants; barley; beta-glucans; cardiovascular diseases; cholesterol; chronic diseases; diabetes; drugs; epidemiological studies; flavonoids; folic acid; lignans; neoplasms; obesity; phenolic acids; phytosterols; risk; risk reduction; whole grain foods
Abstract:: ... Epidemiological studies have consistently shown that regular consumption of whole grain barley reduces the risk of developing chronic diseases. The presence of barley fiber, especially β-glucan in whole grain barley, has been largely credited for these health benefits. However, it is now widely believed that the actions of the fiber component alone do not explain the observed health benefits assoc ...
DOI:: 10.1016/j.jfda.2016.08.002
: https://doi.org/10.1016/j.jfda.2016.08.002

97. Changes in phenolic composition in olive tree parts according to development stage

Author:: Leila Abaza; Amani Taamalli; David Arráez-Román; Antonio Segura-Carretero; Alberto Fernández-Gutierrérez; Mokhtar Zarrouk; Nabil Ben Youssef
Source:: Food research international 2017 v.100 pp. 454-461
ISSN:: 0963-9969
Subject:: Olea europaea; buds; cinnamic acid; detectors; flavonoids; flowers; freeze drying; fruit extracts; fruits; high performance liquid chromatography; leaves; lignans; mass spectrometry; methanol; olives; phenols; secoiridoids; tissues; Tunisia
Abstract:: ... The aim of this study was to investigate the changes in the phenolic profile in different organs (buds, flowers, fruits and leaves) from Chemlali olive variety cultivated in the Center of Tunisia according to development stage. Phenolics recovery was carried out using aqueous methanol from freeze-dried powdered tissues. The extracts were then analyzed by using high performance liquid chromatograph ...
DOI:: 10.1016/j.foodres.2016.12.002
: https://doi.org/10.1016/j.foodres.2016.12.002

98. Characterization of Phase I and Phase II Hepatic Metabolism and Reactive Intermediates of Larrea nitida Cav. and Its Lignan Compounds

Author:: Hyesoo Jeong; Soolin Kim; Jimin Lee; Jin Young Park; Wenmei Zhou; Xiyuan Liu; So Dam Kim; Yun Seon Song; Chang‐Young Jang; Sei‐Ryang Oh; Sangho Choi; Minsun Chang
Source:: Phytotherapy research 2017 v.31 no.1 pp. 140-151
ISSN:: 0951-418X
Subject:: Larrea; NADP (coenzyme); antioxidants; bioactive compounds; cytochrome P-450; enzymes; glutathione; inhibitory concentration 50; isozymes; lignans; liver microsomes; metabolism; metabolites; methanol; models; nicotinamide; nordihydroguaiaretic acid; phosphates; rats; toxicity; uridine; Chile
Abstract:: ... Larrea nitida Cav. (LNC), which belongs to the family Zygophyllaceae, is widely indigenous and used in South America to treat various pathological conditions. It contains the antioxidant and antiinflammatory but toxic nordihydroguaiaretic acid (NDGA) as well as O‐methylated metabolite of NDGA (MNDGA) as bioactive compounds. The hepatic metabolism‐based toxicological potential of extracts of LNC (L ...
DOI:: 10.1002/ptr.5742
: https://doi.org/10.1002/ptr.5742

99. Characterization of some potential medicinal plants from Central Europe by their antioxidant capacity and the presence of metal elements

Author:: Michal Tupec; Veronika Hýsková; Kateřina Bělonožníková; Jakub Hraníček; Václav Červený; Helena Ryšlavá
Source:: Food bioscience 2017 v.20 pp. 43-50
ISSN:: 2212-4292
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Agrimonia eupatoria; Mentha piperita; Origanum vulgare; antioxidant activity; calcium; diet; drinking; electrons; flavonoids; herbal tea; humans; hydrogen; lignans; magnesium; medicinal plants; phenolic acids; plant extracts; polyphenols; potassium; selenium; sodium; sodium chloride; stilbenes; zinc; Central European region
Abstract:: ... Plants contain polyphenolic compounds such as phenolic acids, flavonoids, stilbenes, lignans, etc., which are endowed with antioxidant properties. The aim of this study was to correlate the total phenolic compound and flavonoid content of 15 medicinal plants with their antioxidant properties and to determine some important essential elements (Na, K, Ca, Mg, Zn, Se). The antioxidant capacity was te ...
DOI:: 10.1016/j.fbio.2017.08.001
: https://doi.org/10.1016/j.fbio.2017.08.001

100. Chemical Composition and Immuno‐Modulatory Effects of Urtica dioica L. (Stinging Nettle) Extracts

Author:: Marina Francišković; Raquel Gonzalez‐Pérez; Dejan Orčić; Fermín Sánchez de Medina; Olga Martínez‐Augustin; Emilija Svirčev; Nataša Simin; Neda Mimica‐Dukić
Source:: Phytotherapy research 2017 v.31 no.8 pp. 1183-1191
ISSN:: 0951-418X
Subject:: chemoattractants; kaempferol; secretion; Urtica dioica; chemokine CCL2; glucosides; intestinal mucosa; dietary supplements; liquid chromatography; protective effect; isoquercitrin; rutin; oncogenes; phytopharmaceuticals; humans; linoleate 13S-lipoxygenase; aerial parts; lignans; immune response; chemical composition; monocytes; phenolic acids; inflammation; tandem mass spectrometry; prostaglandin synthase
Abstract:: ... The purpose of this work was to determine the chemical profile of stinging nettle and to provide an insight into the mechanisms by which it ameliorates the immune response. Qualitative and quantitative liquid chromatography tandem mass spectrometry analyses indicated that phenolic acids (5‐O‐caffeoylquinic acid as dominant) and flavonol glycosides (rutin, isoquercitrin, and kaempferol 3‐O‐glucosid ...
DOI:: 10.1002/ptr.5836
: https://doi.org/10.1002/ptr.5836

PubAg

Main content area

Limit your search

Text Availability

Journal

Publication Year

Subject

Search

199 Search Results

Search Results

1. A New Lignan from Cinnamomum burmanii

2. A New Neolignan from the Aerial Parts of Prunella vulgaris var. lilacina

3. A high throughput mass spectrometry screening analysis based on two-dimensional carbon microfiber fractionation system

4. A new lignan and a new terpenoid from Achillea millefolium L

5. Absorption, distribution, metabolism, and excretion of [14C]sesamin in rats

6. Anti-complementary constituents of Anchusa italica

7. Anti-inflammatory neolignans from Epimedium pseudowushanese

8. Antibacterial neolignans from the leaves of Melaleuca bracteata

9. Antioxidant and cytotoxic lignans from the roots of Bupleurum chinense

10. Antiplasmodial Securinega alkaloids from Phyllanthus fraternus: Discovery of natural (+)-allonorsecurinine

11. Arctigenin represses TGF-β-induced epithelial mesenchymal transition in human lung cancer cells

12. Bifidobacterium adolescentis INIA P784: The first probiotic bacterium capable of producing enterodiol from lignan extracts

13. Bioactive lignans and flavones with in vitro antioxidant and neuroprotective properties from Rubus idaeus rhizome

14. Can sesame consumption improve blood pressure? A systematic review and meta‐analysis of controlled trials

15. Chemical Composition and UVA-Protecting Activity of Extracts from Ligustrum vulgare and Olea europaea Leaves

16. Chiral separation and chemical profile of Dengzhan Shengmai by integrating comprehensive with multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

17. Comparative analysis of the in-vitro antioxidant activity and bioactive compounds of flaxseed in China according to variety and geographical origin

18. Comprehensive profiling and characterization of chemical constituents of rhizome of Anemarrhena asphodeloides Bge.

19. Cytotoxic neolignans from the traditional Chinese medicine Daphniphyllum macropodum Miq.

20. Derivatives of the Lignan 7′-Hydroxymatairesinol with Antioxidant Properties and Enhanced Lipophilicity

21. Diarylpropanes and lignans from Horsfieldia tetratepala

22. Diterpenoids and Lignans from Cephalotaxus fortunei

23. Effect of Antibiotics and Diet on Enterolactone Concentration and Metabolome Studied by Targeted and Nontargeted LC–MS Metabolomics

24. Enantiomeric 8-O-4′ type neolignans from red raspberry as potential inhibitors of β-amyloid aggregation

25. Expression in Pichia pastoris and characterization of two novel dirigent proteins for atropselective formation of gossypol

26. Extraction of Flaxseed Oil: A Comparative Study of Three-Phase Partitioning and Supercritical Carbon Dioxide Using Response Surface Methodology

27. Extraction of bioactive compounds from sesame (Sesamum indicum L.) defatted seeds using water and ethanol under sub-critical conditions

28. Fargesin exerts anti-inflammatory effects in THP-1 monocytes by suppressing PKC-dependent AP-1 and NF-ĸB signaling

29. Flavonol glycosides and lignans from the leaves of Opilia amentacea

30. Flaxseed and multigrain mixtures in the development of functional biscuits

31. Functional characterization of the pinoresinol–lariciresinol reductase-2 gene reveals its roles in yatein biosynthesis and flax defense response

32. Furofuran lignan glucosides from the leaves of Vitex negundo var. cannabifolia

33. Furofuran lignans from the Simpson Desert species Eremophila macdonnellii

34. Identification of metabolites in human and rat urine after oral administration of Xiao‐Qing‐Long‐Tang granule using ultra high performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

35. Impact of lignans on the polyunsaturated fatty acid metabolic processing in a rainbow trout (Oncorhynchus mykiss) cell line

36. In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans

37. Kudsuphilactone B, a nortriterpenoid isolated from Schisandra chinensis fruit, induces caspase-dependent apoptosis in human ovarian cancer A2780 cells

38. LC-MS profiling highlights hazelnut (Nocciola di Giffoni PGI) shells as a byproduct rich in antioxidant phenolics

39. Lignans and diterpenes isolated from Tirpitzia ovoidea and their biological activities

40. Lignans and indole alkaloids from the seeds of Centaurea vlachorum Hartvig (Asteraceae), growing wild in Albania and their biological activity

41. Lignans from guaiac resin decrease nitric oxide production in interleukin 1β-treated hepatocytes

42. Lignans from the shed trunk barks of the critically endangered plant Abies beshanzuensis and their anti-neuroinflammatory activities

43. Metabolic signatures altered by in vitro temperature stress in Ajuga bracteosa Wall. ex. Benth.

44. Methyl caffeate and some plant constituents inhibit age-related inflammation: effects on senescence-associated secretory phenotype (SASP) formation

45. Micro-matrix solid-phase dispersion coupled with MEEKC for quantitative analysis of lignans in Schisandrae Chinensis Fructus using molecular sieve TS-1 as a sorbent

46. Musts with Increased Lignan Content Through Addition of Lignan Extracts

47. Neolignan and megastigmane glucosides from the aerial parts of Isodon japonicus with cell protective effects on BaP-induced cytotoxicity

48. Neolignan and monoterpene glycoside from the seeds of Pharbitis nil

49. Neuroprotective Lignans from the Fruits of Schisandra bicolor var. tuberculata

50. New isobaric lignans from Refined Olive Oils as quality markers for Virgin Olive Oils

51. New lignan glycosides from Justicia procumbens

52. New neolignan glycoside from the root of Aralia echinocaulis Hand. -Mazz

53. Phenylpropanoids from the fruits of Nicandra physaloides and their anti-inflammatory activities

54. Physiological effects of γ-linolenic acid and sesamin on hepatic fatty acid synthesis and oxidation

55. Phytochemical analysis of bark from Helietta apiculata Benth and antimicrobial activities

56. Phytochemicals and biological activities of Artemisia sieversiana

57. Pinus pinaster Knot: A Source of Polyphenols against Plasmopara viticola

58. Protective effects of petroleum ether extracts of Herpetospermum caudigerum against α-naphthylisothiocyanate-induced acute cholestasis of rats

59. RP‐HPLC‐DAD‐ESI‐QTOF‐MS based metabolic profiling of the potential Olea europaea by‐product “wood” and its comparison with leaf counterpart

60. Rapid purification of diastereoisomers from Piper kadsura using supercritical fluid chromatography with chiral stationary phases

61. Schisandra chinensis extract decreases chloroacetaldehyde production in rats and attenuates cyclophosphamide toxicity in liver, kidney and brain

62. Sesame (Sesamum indicum L.), an underexploited oil seed crop: Current status, features and importance-A review

63. Seven new lignan glycosides from the branches of Alangium kurzii Craib var. laxifolium

64. Studies on non-phenolic lignans in alkaline cooking

65. The Contents of Lignans in Sesame Seeds and Commercial Sesame Oils of China

66. The lignan (+)‐secoisolariciresinol extracted from flax hulls is an effective protectant of linseed oil and its emulsion against oxidative damage

67. Three new iridoid glycosides isolated from the traditional herb Siphonostegia chinensis with NF-κB inhibitory activity

68. Trends in accumulation of pharmacologically important antioxidant-secondary metabolites in callus cultures of Linum usitatissimum L.

69. Two new lignans from Saururus chinensis

70. Using connectivity map to identify natural lignan justicidin A as a NF-κB suppressor