Publication year rev: 7983-2017 / Subject term: lignans

1. (-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1

Author:: Di Yang; Chen-Xi Xiao; Zheng-Hua Su; Meng-Wei Huang; Ming Qin; Wei-Jun Wu; Wan-Wan Jia; Yi-Zhun Zhu; Jin-Feng Hu; Xin-Hua Liu
Source:: Phytomedicine 2017 v.32 pp. 15-23
ISSN:: 0944-7113
Subject:: Western blotting; anti-inflammatory activity; antineoplastic activity; antioxidants; cardiovascular diseases; drugs; endothelial cells; fluorescent antibody technique; gene expression regulation; heme oxygenase (biliverdin-producing); inducible nitric oxide synthase; inflammation; interleukin-6; lignans; messenger RNA; mitogen-activated protein kinase; necrosis; pathogenesis; phosphorylation; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; superoxide dismutase; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Endothelial inflammation is an increasingly prevalent condition in the pathogenesis of many cardiovascular diseases. (-)-7(S)-hydroxymatairesinol (7-HMR), a naturally occurring plant lignan, possesses both antioxidant and anti-cancer properties and therefore would be a good strategy to suppress tumor necrosis factor-α (TNF-α)-mediated inflammation in vascular endothelial cells (VECs).: The objecti ...
DOI:: 10.1016/j.phymed.2017.04.005
: https://doi.org/10.1016/j.phymed.2017.04.005

2. Absorption, distribution, metabolism, and excretion of [14C]sesamin in rats

Author:: Namino Tomimori; Tomohiro Rogi; Hiroshi Shibata
Source:: Molecular nutrition & food research 2017 v.61 no.8 pp. -
ISSN:: 1613-4125
Subject:: absorption; autoradiography; bile; carbon; cytochrome P-450; excretion; feces; half life; intestinal microorganisms; kidneys; lignans; liver; metabolites; oral administration; pharmacokinetics; radioactivity; radionuclides; rats; sesame seed; tissue distribution; urine
Abstract:: ... SCOPE: Sesamin is a major lignan in sesame seeds and has various physiological effects. Although metabolism of sesamin by cytochrome P450 or intestinal microflora has been reported, little is known concerning the mass balance, pharmacokinetics, and tissue distribution of sesamin. METHODS AND RESULTS: Absorption, distribution, metabolism, and excretion of [¹⁴C]sesamin were investigated after a sing ...
DOI:: 10.1002/mnfr.201600844
: https://doi.org/10.1002/mnfr.201600844

3. Anti-biofilm activity against Staphylococcus aureus MRSA and MSSA of neolignans and extract of Piper regnellii

Author:: Lara Z.S. Brambilla; Eliana H. Endo; Diógenes A.G. Cortez; Benedito P. Dias Filho
Source:: Revista Brasileira de Farmacognosia 2017 v.27 no.1 pp. 112-117
ISSN:: 0102-695X
Subject:: Piper; antibiotic resistance; antimicrobial properties; biofilm; disease control; lignans; methicillin; methicillin-resistant Staphylococcus aureus; methylene chloride; minimum inhibitory concentration; plankton
Abstract:: ... Many infections worldwide are associated with bacterial biofilms. The effects of isolated neolignans (conocarpan and eupomathenoid-5) and the dichloromethane extract of Piper regnellii (Miq.) C. DC., Piperaceae, were tested against isolates of methicillin-resistant Staphylococcus aureus and methicillin-sensitive S. aureus biofilms and S. aureus planktonic cells. The dichloromethane extract present ...
DOI:: 10.1016/j.bjp.2016.08.008
: https://doi.org/10.1016/j.bjp.2016.08.008

4. Anti-complementary constituents of Anchusa italica

Author:: Yu-zhen Hou; Kui-kui Chen; Xi-ling Deng; Ze-long Fu; Dao-feng Chen; Qi Wang
Source:: Natural product research 2017 v.31 no.21 pp. 2572-2574
ISSN:: 1478-6427
Subject:: Anchusa azurea; alcohols; alkaloids; complement; flavonoids; fractionation; lignans; triterpenoids
Abstract:: ... Activity-guided fractionation for complement inhibitors led to the isolation of 24 known compounds from Anchusa italica . Chemical types include eight megastigmane compounds, five triterpenoid compounds, five lignan compounds, three flavonoid compounds, two alkaloid compounds and one phenthyl alcohol compound. Among which, a lignan (medioresinol), an alkaloid (5-hydroxypyrrolidin-2-one) and a flav ...
DOI:: 10.1080/14786419.2017.1320789
: https://doi.org/10.1080/14786419.2017.1320789

5. Anti-inflammatory neolignans from Epimedium pseudowushanese

Author:: Huihui Ti; Ping Wu; Liangxiong Xu; Xiaoyi Wei
Source:: Natural product research 2017 v.31 no.22 pp. 2621-2628
ISSN:: 1478-6427
Subject:: Epimedium; anti-inflammatory activity; lignans; secretion; spectroscopy; tumor necrosis factor-alpha
Abstract:: ... One new 8- O -4′ neolignan has been isolated from Epimedium pseudowushanese B. L. Guo, together with nine other known neolignans. The structures of these neolignans were elucidated using spectroscopic and chemical techniques, and their anti-inflammatory activities were also evaluated. The results of these experiments revealed that compound 6 was the most potent of the 10 different compounds tested ...
DOI:: 10.1080/14786419.2017.1289200
: https://doi.org/10.1080/14786419.2017.1289200

6. Antibacterial neolignans from the leaves of Melaleuca bracteata

Author:: Can Li; Hongxin Liu; Liyun Zhao; Weimin Zhang; Shengxiang Qiu; Xiaoyun Yang; Haibo Tan
Source:: Fitoterapia 2017 v.120 pp. 171-176
ISSN:: 0367-326X
Subject:: Melaleuca; aldehydes; antibiotic resistance; antimicrobial properties; biochemical pathways; biomimetics; leaves; lignans; methicillin; methicillin-resistant Staphylococcus aureus; odors; spectral analysis
Abstract:: ... Phytochemical study on the leaves of Melaleuca bracteata resulted in the isolation of ten compounds including three new neolignans, named melaleucins A–C (1–3). Among them, melaleucin B shares a rarely occurring nor-neolignan skeleton, and both melaleucins B and C bear a novel aldehyde moiety, which might also be response for the delicate fragrance of M. bracteata. Their structures were extensivel ...
DOI:: 10.1016/j.fitote.2017.06.015
: https://doi.org/10.1016/j.fitote.2017.06.015

7. Antioxidant and cytotoxic lignans from the roots of Bupleurum chinense

Author:: Dan-Qi Li; Di Wang; Le Zhou; Ling-Zhi Li; Qing-Bo Liu; Ying-Ying Wu; Jing-Yu Yang; Shao-Jiang Song; Chun-Fu Wu
Source:: Journal of Asian natural products research 2017 v.19 no.5 pp. 519-527
ISSN:: 1477-2213
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Bupleurum chinense; antioxidant activity; bioactive compounds; cytotoxicity; ethanol; fluorouracil; free radical scavengers; glucosides; inhibitory concentration 50; lignans; neoplasm cells; nuclear magnetic resonance spectroscopy; roots; spectral analysis
Abstract:: ... In the search for biologically active compounds from the roots of Bupleurum chinense D C., phytochemical investigation of its ethanol extract led to the isolation and identification of a new 8- O -4′ neolignan glucoside, saikolignanoside A (1), along with eight known lignans (2–9). Their structures were determined on the basis of IR, UV, HRESIMS, and NMR spectroscopic analyses. The antioxidant and ...
DOI:: 10.1080/10286020.2016.1234456
: https://doi.org/10.1080/10286020.2016.1234456

8. Antiplasmodial Securinega alkaloids from Phyllanthus fraternus: Discovery of natural (+)-allonorsecurinine

Author:: Gustav Komlaga; Grégory Genta-Jouve; Sandrine Cojean; Rita A. Dickson; Merlin L.K. Mensah; Philippe M. Loiseau; Pierre Champy; Mehdi A. Beniddir
Source:: Tetrahedron letters 2017 pp. -
ISSN:: 0040-4039
Subject:: Phyllanthus fraternus; Plasmodium falciparum; Securinega; alkaloids; antimalarials; antiparasitic properties; chemical reactions; chemical structure; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:: ... The chemical investigation of the antimalarial plant Phyllanthus fraternus G. L. Webster (Phyllanthaceae) resulted in the discovery of the Securinega alkaloid (+)-allonorsecurinine (1), previously reported as a synthetic compound, together with the known ent-norsecurinine (2), nirurine (3), bubbialine (4), epibubbialine (5) and the lignan phyllanthin (6). The structure and absolute configuration o ...
DOI:: 10.1016/j.tetlet.2017.08.045
: https://doi.org/10.1016/j.tetlet.2017.08.045

9. Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome

Author:: Shimeng Zhang; Liangjun Jiang; Fengyuan Che; Yucheng Lu; Zhongxiang Xie; Hao Wang
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: Arctium lappa; brain; infarction; inflammasomes; interleukin-18; interleukin-1beta; ischemia; lignans; neuroprotective effect; protein synthesis; rats; secretion; signal transduction; stroke; surgery; water content
Abstract:: ... Arctigenin (ARC), a phenylpropanoid dibenzylbutyrolactone lignan derived from Arctium lappa L, has been reported to protect against cerebral ischemia injury in rats, but the underlying mechanism is unclear. In this study, we investigated whether ARC ameliorated ischemic stroke by inhibiting NLRP3 inflammasome-derived neuroinflammation and whether SIRT1 signaling was involved in this process. ARC ( ...
DOI:: 10.1016/j.bbrc.2017.08.062
: https://doi.org/10.1016/j.bbrc.2017.08.062

10. Arctigenin represses TGF-β-induced epithelial mesenchymal transition in human lung cancer cells

Author:: Yanrui Xu; Zhiyuan Lou; Seong-Ho Lee
Source:: Biochemical and biophysical research communications 2017 v.493 pp. 934-939
ISSN:: 0006-291X
Subject:: Asteraceae; antineoplastic activity; beta catenin; cadherins; dose response; epithelium; humans; lignans; lung neoplasms; metastasis; mitogen-activated protein kinase; models; neoplasm cells; phosphorylation; snails; toxicity; transcription (genetics)
Abstract:: ... Arctigenin (ARC) is a lignan that is abundant in Asteraceae plants, which show anti-inflammatory and anti-cancer activities. The current study investigated whether ARC affects cancer progression and metastasis, focusing on EMT using invasive human non-small cell lung cancer (NSCLC) cells. No toxicity was observed in the cells treated with different doses of ARC (12–100 μM). The treatment of ARC re ...
DOI:: 10.1016/j.bbrc.2017.09.117
: https://doi.org/10.1016/j.bbrc.2017.09.117

11. Association between Dietary Share of Ultra-Processed Foods and Urinary Concentrations of Phytoestrogens in the US

Author:: Eurídice Martínez Steele; Carlos A. Monteiro
Source:: Nutrients 2017 v.9 no.3 pp. -
ISSN:: 2072-6643
Subject:: National Health and Nutrition Examination Survey; additives; creatinine; daidzein; diet recall; dietary energy sources; education; food processing; genistein; geometry; household income; ingredients; lactones; lignans; minimally processed foods; models; nationalities and ethnic groups; nutrients; plant estrogens; United States
Abstract:: ... The aim of this study was to examine the relationship between dietary contribution of ultra-processed foods and urinary phytoestrogen concentrations in the US. Participants from cross-sectional 2009–2010 National Health and Nutrition Examination Survey aged 6+ years, selected to measure urinary phytoestrogens and with one 24-h dietary recall were evaluated (2692 participants). Food items were clas ...
DOI:: 10.3390/nu9030209
PubMed:: 28264475
PubMed Central:: PMC5372872
: https://doi.org/10.3390/nu9030209

12. Association between Urinary Phytoestrogens and C-reactive Protein in the Continuous National Health and Nutrition Examination Survey

Author:: Michael K. Reger; Terrell W. Zollinger; Ziyue Liu; Josette Jones; Jianjun Zhang
Source:: Journal of the American College of Nutrition 2017 v.36 no.6 pp. 434-441
ISSN:: 1541-1087
Subject:: C-reactive protein; National Health and Nutrition Examination Survey; biomarkers; blood serum; cardiovascular diseases; confidence interval; inflammation; lignans; neoplasms; plant estrogens; risk; risk reduction; United States
Abstract:: ... Objective : A reduced risk of some cancers and cardiovascular disease associated with phytoestrogen intake may be mediated through its effect on serum C-reactive protein (CRP; an inflammation biomarker). Therefore, this study examined the associations between urinary phytoestrogens and serum CRP. Methods : Urinary phytoestrogen and serum CRP data obtained from 6009 participants aged ≥ 40 years in ...
DOI:: 10.1080/07315724.2017.1318722
: https://doi.org/10.1080/07315724.2017.1318722

13. Association of Polyphenol Biomarkers with Cardiovascular Disease and Mortality Risk: A Systematic Review and Meta-Analysis of Observational Studies

Author:: Johanna Rienks; Janett Barbaresko; Ute Nöthlings
Source:: Nutrients 2017 v.9 no.4 pp. -
ISSN:: 2072-6643
Subject:: biomarkers; blood; disease prevention; epidemiological studies; kaempferol; lactones; lignans; meta-analysis; metabolites; microorganisms; models; mortality; myocardial infarction; nutrition assessment; observational studies; polyphenols; systematic review; urine
Abstract:: ... Epidemiologic studies have suggested an inverse association between flavonoids and cardiovascular disease (CVD). However, the results might have been influenced by the use of dietary assessment methods, which are error prone. The aim of this paper was to systematically review and analyse the literature for evidence of associations between polyphenol biomarkers and CVD and mortality risk in observa ...
DOI:: 10.3390/nu9040415
PubMed:: 28441720
PubMed Central:: PMC5409754
: https://doi.org/10.3390/nu9040415

14. Asymmetric synthesis of furofurans

Author:: Manat Pohmakotr; Chutima Kuhakarn; Vichai Reutrakul; Darunee Soorukram
Source:: Tetrahedron letters 2017 pp. -
ISSN:: 0040-4039
Subject:: bioactive properties; chemical reactions; chemical structure; lignans; stereochemistry; stereoselectivity
Abstract:: ... Furofurans are one of the largest sub-types of classical lignans which have been found to possess a broad range of important biological activities. Tremendous efforts have been directed to develop synthetic methodologies for the synthesis of furofurans, especially in a stereoselective manner, due to their interesting bioactivities associated with the structural and stereochemical complexity. This ...
DOI:: 10.1016/j.tetlet.2017.11.011
: https://doi.org/10.1016/j.tetlet.2017.11.011

15. Bifidobacterium adolescentis INIA P784: The first probiotic bacterium capable of producing enterodiol from lignan extracts

Author:: Pilar Gaya; Ángela Peirotén; Margarita Medina; José Ma Landete
Source:: Journal of functional foods 2017 v.29 pp. 269-274
ISSN:: 1756-4646
Subject:: Bifidobacterium adolescentis; bioavailability; biotechnology; functional foods; human health; intestinal microorganisms; lactic acid bacteria; lignans; linseed; matairesinol; metabolism; probiotics
Abstract:: ... Lignans are phytoestrogens found in plant foods and especially in flax seeds. Although lignans present a low bioavailability, their transformation into the enterolignans enterodiol (END) and enterolactone (ENL) is associated with beneficial effects on human health. Lignan metabolism was studied in 90 lactic acid bacteria and bifidobacteria finding a wide distribution of the ability to deglycosylat ...
DOI:: 10.1016/j.jff.2016.12.044
: https://doi.org/10.1016/j.jff.2016.12.044

16. Bioactive Asarone-Derived Phenylpropanoids from the Rhizome of Acorus tatarinowii Schott

Author:: Gao En; Zhou Zheng-Qun; Zou Jian; Yu Yang; Feng Xiao-Lin; Chen Guo-Dong; He Rong-Rong; Yao Xin-Sheng; Gao Hao
Source:: Journal of natural products 2017 v.80 no.11 pp. 2923-2929
ISSN:: 1520-6025
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Acorus gramineus; acarbose; acetylcholinesterase; alpha-glucosidase; antioxidant activity; antioxidants; benzene; drugs; enantiomers; enzyme inhibition; high performance liquid chromatography; inhibitory concentration 50; lignans; phenylpropanoids; rhizomes; spectral analysis
Abstract:: ... Eight new (1a/1b, 2a, 3a, 4a/4b, and 5a/5b) and seven known (2b, 3b, and 6–10) asarone-derived phenylpropanoids, a known asarone-derived lignan (12), and four known lignan analogues (11 and 13–15) were isolated from the rhizome of Acorus tatarinowii Schott. The structures were elucidated via comprehensive spectroscopic analyses, modified Mosher’s method, and quantum chemical calculations. Compound ...
DOI:: 10.1021/acs.jnatprod.7b00457
: https://doi.org/10.1021/acs.jnatprod.7b00457

17. Bioactive Glycosides from the Twigs of Litsea cubeba

Author:: Wang Ling-Yan; Chen Ming-Hua; Wu Jiang; Sun Hua; Liu Wei; Qu Yu-Hong; Li Yan-Cheng; Wu Yu-Zhuo; Li Rui; Zhang Dan; Wang Su-Juan; Lin Sheng
Source:: Journal of natural products 2017 v.80 no.6 pp. 1808-1818
ISSN:: 1520-6025
Subject:: Litsea cubeba; X-ray diffraction; air drying; branches; circular dichroism spectroscopy; glucosides; human cell lines; inhibitory concentration 50; lignans; medicinal plants; nuclear magnetic resonance spectroscopy
Abstract:: ... The air-dried twigs of Litsea cubeba, a traditional Chinese medicinal tree, afforded 10 new aromatic glycosides (1–10) and 26 known analogues. Their structures were assigned by extensive 1D and 2D NMR experiments, and the absolute configurations were resolved by chemical methods, electronic circular dichroism, specific rotation, and X-ray crystallographic analysis. Compound 4 is the first example ...
DOI:: 10.1021/acs.jnatprod.6b01189
: https://doi.org/10.1021/acs.jnatprod.6b01189

18. Bioactive lignans and flavones with in vitro antioxidant and neuroprotective properties from Rubus idaeus rhizome

Author:: Yang Xu; Ling-Zhi Li; Qian Cong; Wei Wang; Xiao-Li Qi; Ying Peng; Shao-Jiang Song
Source:: Journal of functional foods 2017 v.32 pp. 160-169
ISSN:: 1756-4646
Subject:: Rubus idaeus; antioxidant activity; antioxidants; ethanol; flavones; fruits; herbal medicines; leaves; lignans; neurodegenerative diseases; neuroprotective effect; rhizomes
Abstract:: ... Rubus idaeus L. is caneberries from the genus Rubus that have been cultivated as food and herbal medicine, and is known to demonstrate strong antioxidant capability. In the present study, five new lignans, along with 13 known compounds, were isolated from ethanol extracts of R. idaeus rhizomes. An HPLC-MS/MS method was established and successfully applied to quantification of 14 compounds from lea ...
DOI:: 10.1016/j.jff.2017.02.022
: https://doi.org/10.1016/j.jff.2017.02.022

19. Bioactive phenolics from in vitro cultures of Lactuca aculeata Boiss. et Kotschy

Author:: Anna Stojakowska; Janusz Malarz
Source:: Phytochemistry letters 2017 v.19 pp. 7-11
ISSN:: 1874-3900
Subject:: Lactuca; caffeic acid; callus culture; chlorogenic acid; glucosides; lignans; sesquiterpenoid lactones
Abstract:: ... A callus culture of Lactuca aculeata, except for commonly distributed caffeic acid derivatives typically found in the Asteraceae family (chlorogenic acid, methyl caffeate, 1,5- dicaffeoylquinic acid), yielded bioactive lignans: (+)-5-methoxybalanophonin, syringaresinol, (+)-balanophonin-9-O-β-glucopyranoside, (+) buddlenol A, (−)-dihydrodehydrodiconiferyl alcohol-4-O-β-glucopyranoside and (−)-dihy ...
DOI:: 10.1016/j.phytol.2016.11.003
: https://doi.org/10.1016/j.phytol.2016.11.003

20. Bioactive phytochemicals in barley

Author:: Emmanuel Idehen; Yao Tang; Shengmin Sang
Source:: Yàowù shípǐn fēnxī 2017 v.25 no.1 pp. 148-161
ISSN:: 1021-9498
Subject:: antioxidants; barley; beta-glucans; cardiovascular diseases; cholesterol; chronic diseases; diabetes; drugs; epidemiological studies; flavonoids; folic acid; lignans; neoplasms; obesity; phenolic acids; phytosterols; risk; risk reduction; whole grain foods
Abstract:: ... Epidemiological studies have consistently shown that regular consumption of whole grain barley reduces the risk of developing chronic diseases. The presence of barley fiber, especially β-glucan in whole grain barley, has been largely credited for these health benefits. However, it is now widely believed that the actions of the fiber component alone do not explain the observed health benefits assoc ...
DOI:: 10.1016/j.jfda.2016.08.002
: https://doi.org/10.1016/j.jfda.2016.08.002

21. Biotransformation of lignan glycoside to its aglycone by Woodfordia fruticosa flowers: quantification of compounds using a validated HPTLC method

Author:: Shikha Mishra; Vidhu Aeri
Source:: Pharmaceutical biology 2017 v.55 no.1 pp. 360-366
ISSN:: 1744-5116
Subject:: Saraca asoca; Woodfordia fruticosa; bark; biotransformation; fermentation; flowers; glycosides; lignans; plant estrogens; solvents
Abstract:: ... Context: Saraca asoca Linn. (Caesalpiniaceae) is an important traditional remedy for gynaecological disorders and it contains lyoniside, an aryl tetralin lignan glycoside. The aglycone of lyoniside, lyoniresinol possesses structural similarity to enterolignan precursors which are established phytoestrogens. Objectives: This work illustrates biotransformation of lyoniside to lyoniresinol using Wood ...
DOI:: 10.1080/13880209.2016.1238948
PubMed:: 27931157
PubMed Central:: PMC6130600
: https://doi.org/10.1080/13880209.2016.1238948

22. Can sesame consumption improve blood pressure? A systematic review and meta‐analysis of controlled trials

Author:: Hossein Khosravi‐Boroujeni; Elham Nikbakht; Ernesta Natanelov; Saman Khalesi
Source:: Journal of the science of food and agriculture 2017 v.97 no.10 pp. 3087-3094
ISSN:: 0022-5142
Subject:: blood pressure; databases; hypertension; lignans; meta-analysis; myocardial infarction; phytosterols; polyunsaturated fatty acids; renal failure; risk factors; stroke; systematic review
Abstract:: ... Hypertension is a major risk factor for cardiovascular disease, myocardial infarction, stroke and renal failure. Sesame consumption may benefit blood pressure (BP) owing to its high polyunsaturated fatty acid, fibre, phytosterol and lignan contents. To clarify this, a systematic review and meta‐analysis of controlled trials was conducted. The PubMed (MEDLINE), Cumulative Index to Nursing and Allie ...
DOI:: 10.1002/jsfa.8361
: https://doi.org/10.1002/jsfa.8361

23. Changes in phenolic composition in olive tree parts according to development stage

Author:: Leila Abaza; Amani Taamalli; David Arráez-Román; Antonio Segura-Carretero; Alberto Fernández-Gutierrérez; Mokhtar Zarrouk; Nabil Ben Youssef
Source:: Food research international 2017 v.100 pp. 454-461
ISSN:: 0963-9969
Subject:: Olea europaea; buds; cinnamic acid; detectors; flavonoids; flowers; freeze drying; fruit extracts; fruits; high performance liquid chromatography; leaves; lignans; mass spectrometry; methanol; olives; phenols; secoiridoids; tissues; Tunisia
Abstract:: ... The aim of this study was to investigate the changes in the phenolic profile in different organs (buds, flowers, fruits and leaves) from Chemlali olive variety cultivated in the Center of Tunisia according to development stage. Phenolics recovery was carried out using aqueous methanol from freeze-dried powdered tissues. The extracts were then analyzed by using high performance liquid chromatograph ...
DOI:: 10.1016/j.foodres.2016.12.002
: https://doi.org/10.1016/j.foodres.2016.12.002

24. Characterization of Phase I and Phase II Hepatic Metabolism and Reactive Intermediates of Larrea nitida Cav. and Its Lignan Compounds

Author:: Hyesoo Jeong; Soolin Kim; Jimin Lee; Jin Young Park; Wenmei Zhou; Xiyuan Liu; So Dam Kim; Yun Seon Song; Chang‐Young Jang; Sei‐Ryang Oh; Sangho Choi; Minsun Chang
Source:: Phytotherapy research 2017 v.31 no.1 pp. 140-151
ISSN:: 0951-418X
Subject:: Larrea; NADP (coenzyme); antioxidants; bioactive compounds; cytochrome P-450; enzymes; glutathione; inhibitory concentration 50; isozymes; lignans; liver microsomes; metabolism; metabolites; methanol; models; nicotinamide; nordihydroguaiaretic acid; phosphates; rats; toxicity; uridine; Chile
Abstract:: ... Larrea nitida Cav. (LNC), which belongs to the family Zygophyllaceae, is widely indigenous and used in South America to treat various pathological conditions. It contains the antioxidant and antiinflammatory but toxic nordihydroguaiaretic acid (NDGA) as well as O‐methylated metabolite of NDGA (MNDGA) as bioactive compounds. The hepatic metabolism‐based toxicological potential of extracts of LNC (L ...
DOI:: 10.1002/ptr.5742
: https://doi.org/10.1002/ptr.5742

25. Chemical Composition and Immuno‐Modulatory Effects of Urtica dioica L. (Stinging Nettle) Extracts

Author:: Marina Francišković; Raquel Gonzalez‐Pérez; Dejan Orčić; Fermín Sánchez de Medina; Olga Martínez‐Augustin; Emilija Svirčev; Nataša Simin; Neda Mimica‐Dukić
Source:: Phytotherapy research 2017 v.31 no.8 pp. 1183-1191
ISSN:: 0951-418X
Subject:: chemoattractants; kaempferol; secretion; Urtica dioica; chemokine CCL2; glucosides; intestinal mucosa; dietary supplements; liquid chromatography; protective effect; isoquercitrin; rutin; oncogenes; phytopharmaceuticals; humans; linoleate 13S-lipoxygenase; aerial parts; lignans; immune response; chemical composition; monocytes; phenolic acids; inflammation; tandem mass spectrometry; prostaglandin synthase
Abstract:: ... The purpose of this work was to determine the chemical profile of stinging nettle and to provide an insight into the mechanisms by which it ameliorates the immune response. Qualitative and quantitative liquid chromatography tandem mass spectrometry analyses indicated that phenolic acids (5‐O‐caffeoylquinic acid as dominant) and flavonol glycosides (rutin, isoquercitrin, and kaempferol 3‐O‐glucosid ...
DOI:: 10.1002/ptr.5836
: https://doi.org/10.1002/ptr.5836

26. Chemical Composition and UVA-Protecting Activity of Extracts from Ligustrum vulgare and Olea europaea Leaves

Author:: Monika E. Czerwińska; Katarzyna Duszak; Andrzej Parzonko; Anna K. Kiss
Source:: Acta biologica Cracoviensia 2017 v.58 no.2 pp. 45-55
ISSN:: 1898-0295
Subject:: Ligustrum vulgare; Olea europaea; apoptosis; cell viability; chemical composition; fibroblasts; flavonoids; herbal medicines; humans; leaf extracts; leaves; lignans; models; oleuropein; olives; phenylpropanoids; propidium; protective effect; reactive oxygen species; skin diseases; staining; Mediterranean region; Northern European region
Abstract:: ... Plants belonging to the family Oleaceae have been traditionally used in treatment of various inflammatory skin disorders. One of the most well-known species is Olea europaea L. (olive), cultivated in the Mediterranean countries. Another species is Ligustrum vulgare L. (common privet), occurring particularly in Northern Europe and Asia.The aim of the study was a comparison of the composition of aqu ...
DOI:: 10.1515/abcsb-2016-0016
: https://doi.org/10.1515/abcsb-2016-0016

27. Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa

Author:: Kuo Ping-Chung; Hung Hsin-Yi; Nian Chi-Wei; Hwang Tsong-Long; Cheng Ju-Chien; Kuo Daih-Huang; Lee E-Jian; Tai Shih-Huang; Wu Tian-Shung
Source:: Journal of natural products 2017 v.80 no.4 pp. 1055-1064
ISSN:: 1520-6025
Subject:: Forsythia suspensa; anti-inflammatory activity; chemical composition; diterpenoids; elastase; fruits; inhibitory concentration 50; lignans; spectroscopy; superoxide anion; triterpenoids
Abstract:: ... Fifty compounds were isolated from the fruits of Forsythia suspensa, including 13 new compounds characterized as eight new diterpenoids (1–8), three new lignans (9–11), a new iridoid (12), and a new triterpenoid (13). Their structures were established on the basis of spectroscopic and spectrometric analysis. Most of the isolated compounds were examined for their anti-inflammatory activity in vitro ...
DOI:: 10.1021/acs.jnatprod.6b01141
: https://doi.org/10.1021/acs.jnatprod.6b01141

28. Chemical profiling and antioxidant evaluation of Yangxinshi Tablet by HPLC–ESI-Q-TOF-MS/MS combined with DPPH assay

Author:: Junfeng Zhu; Xiaojiao Yi; Jinghui Zhang; Shuqing Chen; Yongjiang Wu
Source:: Journal of chromatography 2017 v.1060 pp. 262-271
ISSN:: 1570-0232
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Oriental traditional medicine; alkaloids; anthraquinones; antioxidant activity; ascorbic acid; cardiovascular diseases; chemical composition; clinical trials; coumarin; flavanoids; free radical scavengers; glycosides; high performance liquid chromatography; inhibitory concentration 50; lignans; mass spectrometry; mechanism of action; oral administration; rapid methods; rats; salvianolic acid; screening; triterpenoids
Abstract:: ... Yangxinshi Tablet (YXST) is a Chinese patent medicine commonly used to treat cardiovascular diseases. However, its detailed chemical basis and mechanisms of action have not been clarified. In this study, high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (HPLC–ESI-Q-TOF-MS) was applied for comprehensive analysis of the chemical c ...
DOI:: 10.1016/j.jchromb.2017.06.022
: https://doi.org/10.1016/j.jchromb.2017.06.022

29. Chiral separation and chemical profile of Dengzhan Shengmai by integrating comprehensive with multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

Author:: Ning Sheng; Hao Zheng; Yao Xiao; Zhe Wang; Menglin Li; Jinlan Zhang
Source:: Journal of chromatography 2017 v.1517 pp. 97-107
ISSN:: 0021-9673
Subject:: Oriental traditional medicine; chemical composition; comprehensive two-dimensional liquid chromatography; cutting; flavonoids; herbs; high performance liquid chromatography; isomers; lignans; mass spectrometry; saponins
Abstract:: ... Chemical profile for Chinese medicine formulas composed of several herbs is always a challenge due to a big array of small molecules with high chemical diversity so much as isomers. The present paper develops a feasible strategy to characterize and identify complex chemical constituents of a four-herb traditional Chinese medicine formula, Denzhan Shenmai (DZSM) by integrating comprehensive two-dim ...
DOI:: 10.1016/j.chroma.2017.08.037
: https://doi.org/10.1016/j.chroma.2017.08.037

30. Comparative analysis of the in-vitro antioxidant activity and bioactive compounds of flaxseed in China according to variety and geographical origin

Author:: Qianchun Deng; Xiao Yu; Fangli Ma; Jiqu Xu; Fenghong Huang; Qingde Huang; Feng Sheng
Source:: International journal of food properties 2017 v.20 no.sup3 pp. S2708
ISSN:: 1094-2912
Subject:: 2,2-diphenyl-1-picrylhydrazyl; alpha-linolenic acid; antioxidant activity; antioxidants; bioactive compounds; chemometrics; glucosides; lignans; linseed; p-coumaric acid; phytosterols; principal component analysis; provenance; syringic acid; China
Abstract:: ... The present study aimed to use a chemometric study to compare the in-vitro antioxidant activities and bioactive compounds of flaxseed based on the variety and geographical origins, and further explore the specific components constructed the endogenous antioxidant system of flaxseed in China. The differential contents of α-linolenic acid (35.83–58.91%), lignans (11.37–33.31 mg/g), total phenolic ac ...
DOI:: 10.1080/10942912.2017.1402029
: https://doi.org/10.1080/10942912.2017.1402029

31. Composition and Statistical Analysis of Biophenols in Apulian Italian EVOOs

Author:: Andrea Ragusa; Carla Centonze; Maria Elena Grasso; Maria Francesca Latronico; Pier Francesco Mastrangelo; Francesco Paolo Fanizzi; Michele Maffia
Source:: Foods 2017 v.6 no.10 pp. -
ISSN:: 2304-8158
Subject:: Mediterranean diet; Olea europaea; alpha-tocopherol; antioxidant activity; cultivars; dietary supplements; discriminant analysis; extra-virgin olive oil; harvesting; high performance liquid chromatography; least squares; lignans; luteolin; metabolites; milling; principal component analysis; Italy
Abstract:: ... Extra-virgin olive oil (EVOO) is among the basic constituents of the Mediterranean diet. Its nutraceutical properties are due mainly, but not only, to a plethora of molecules with antioxidant activity known as biophenols. In this article, several biophenols were measured in EVOOs from South Apulia, Italy. Hydroxytyrosol, tyrosol and their conjugated structures to elenolic acid in different forms w ...
DOI:: 10.3390/foods6100090
PubMed:: 29057813
PubMed Central:: PMC5664029
: https://doi.org/10.3390/foods6100090

32. Comprehensive profiling and characterization of chemical constituents of rhizome of Anemarrhena asphodeloides Bge.

Author:: De Ji; Zi-yan Huang; Cheng-hao Fei; Wei-wei Xue; Tu-lin Lu
Source:: Journal of chromatography 2017 v.1060 pp. 355-366
ISSN:: 1570-0232
Subject:: Anemarrhena asphodeloides; chemical composition; cyclic peptides; fatty acids; flavones; herbal medicines; ions; lignans; mass spectrometry; metabolites; quality control; rhizomes; steroid saponins; ultra-performance liquid chromatography; xanthones; China
Abstract:: ... The rhizome of Anemarrhena asphodeloides Bge. is commonly used as an herbal medicine in China. In this study, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) was used, in both negative and positive ion modes, to comprehensively analyze the chemical constituents of A. asphodeloides. From the intact precursor ions, MS/MS fragmenta ...
DOI:: 10.1016/j.jchromb.2017.06.032
: https://doi.org/10.1016/j.jchromb.2017.06.032

33. The Contents of Lignans in Sesame Seeds and Commercial Sesame Oils of China

Author:: Long‐Kai Shi; Rui‐Jie Liu; Qing‐Zhe Jin; Xing‐Guo Wang
Source:: The journal of the American Oil Chemists' Society 2017 v.94 no.8 pp. 1035-1044
ISSN:: 0003-021X
Subject:: high performance liquid chromatography; lignans; seeds; sesame oil; sesame seed; China
Abstract:: ... In this study, the concentrations of three lignans in 100 sesame seeds and 56 sesame oils were determined using a newly developed method based on high‐performance liquid chromatography coupled with a UV/Vis detector. Total lignan contents in sesame seed and oil samples ranged from 2.52 to 12.76 and 3.38 to 11.53 mg/g, respectively. Black sesame seeds showed higher sesamin content (range 1.98–9.41 ...
DOI:: 10.1007/s11746-017-3018-7
: https://doi.org/10.1007/s11746-017-3018-7

34. Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies

Author:: Agnieszka Szopa; Radosław Ekiert; Halina Ekiert
Source:: Phytochemistry reviews 2017 v.16 no.2 pp. 195-218
ISSN:: 1568-7767
Subject:: Magnolia; Schisandra chinensis; analytical methods; bioactive compounds; fruit extracts; fruits; humans; industry; lignans; medicinal plants; medicinal properties; medicine; therapeutics; vines; East Asia
Abstract:: ... Schisandra chinensis Turcz. (Baill.) is a plant species whose fruits have been well known in Far Eastern medicine for a long time. However, schisandra seems to be a plant still underestimated in contemporary therapy still in the countries of East Asia. The article presents latest available information on the chemical composition of this plant species. Special attention is given to dibenzo cyclooct ...
DOI:: 10.1007/s11101-016-9470-4
PubMed:: 28424569
PubMed Central:: PMC5378736
: https://doi.org/10.1007/s11101-016-9470-4

35. Cytotoxic neolignans from the traditional Chinese medicine Daphniphyllum macropodum Miq.

Author:: Xinhua Ma; Jie Yang; Christopher L. Brown; Chao Wang; Shihao Deng; Ruifang Ke; Shicheng Xu; Mi Huang; Xinzhou Yang; Yunjiang Feng
Source:: RSC advances 2017 v.7 no.83 pp. 52970-52976
ISSN:: 2046-2069
Subject:: Daphniphyllum; Oriental traditional medicine; apoptosis; benzaldehyde; caspase-3; caspase-9; cell growth; cell lines; circular dichroism spectroscopy; cytotoxicity; dose response; humans; lignans; mitochondria; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; seeds; spectral analysis
Abstract:: ... Four new neolignans, (E)-3-(hydroxymethyl)-2-(4-hydroxyphenyl)-5-(prop-1-en-1-yl)benzofuran-6-ol (1), methyl (E)-6-hydroxy-2-(4-hydroxyphenyl)-5-(prop-1-en-1-yl)benzofuran-3-carboxylate (2), (R)-4-hydroxy-3-(1-(4-hydroxyphenyl)propan-2-yl)benzaldehyde (3) and methyl (E,R)-3-(4-hydroxy-3-(1-(4-hydroxyphenyl)propan-2-yl)phenyl)acrylate (4) were isolated from the seeds of Daphniphyllum macropodum Miq ...
DOI:: 10.1039/c7ra09569d
: https://doi.org/10.1039/c7ra09569d

36. Derivatives of the Lignan 7′-Hydroxymatairesinol with Antioxidant Properties and Enhanced Lipophilicity

Author:: Moraux Thomas; Dumarçay Stéphane; Gérardin Philippe; Gérardin-Charbonnier Christine
Source:: Journal of natural products 2017 v.80 no.6 pp. 1783-1790
ISSN:: 1520-6025
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Abies alba; Picea abies; Pseudotsuga menziesii; alpha-tocopherol; antioxidant activity; ascorbic acid; butylated hydroxytoluene; esterification; hydrophobicity; inhibitory concentration 50; lignans; ultra-performance liquid chromatography
Abstract:: ... The lignan 7′-hydroxymatairesinol (1), extracted from the knotwoods of fir (Abies alba), spruce (Picea abies), and Douglas fir (Pseudotsuga menziesii), exhibited unexpected reactivity when esterification reactions were attempted on the hydroxy group at position C-7′. To circumvent the rapid intramolecular cyclization procedure, leading quantitatively to the lignan conidendrin (7), a simple strateg ...
DOI:: 10.1021/acs.jnatprod.6b01124
: https://doi.org/10.1021/acs.jnatprod.6b01124

37. Diarylpropanes and lignans from Horsfieldia tetratepala

Author:: Shou-Zhen Du; Zhi-Chong Wang; Ying Liu; Rui Zhan; Ye-Gao Chen
Source:: Phytochemistry letters 2017 v.19 pp. 98-100
ISSN:: 1874-3900
Subject:: acetone; branches; cytotoxicity; lignans; neoplasms; spectral analysis
Abstract:: ... Two new diarylpropanes (1–2), four known compounds, and a new artifact, were isolated from 70% aqueous acetone extract of the twigs of Horsfieldia tetratepala. Their structures were elucidated by spectroscopic analysis. Cytotoxicity evaluation against five cancer cell lines showed that none of these compounds was cytotoxic. ...
DOI:: 10.1016/j.phytol.2016.12.018
: https://doi.org/10.1016/j.phytol.2016.12.018

38. Dibenzocyclooctadiene lignans from Kadsura heteroclita

Author:: Yuan-Qing Luo; Miao Liu; Jin Wen; Wei-Guang Wang; Kun Hu; Xiao-Nian Li; Xue Du; Jian-Xin Pu; Han-Dong Sun
Source:: Fitoterapia 2017 v.119 pp. 150-157
ISSN:: 0367-326X
Subject:: X-ray diffraction; cytotoxicity; inhibitory concentration 50; lignans; spectroscopy; stems
Abstract:: ... Sixteen dibenzocyclooctadiene lignans, including eight new ones, kadheterins A–H (1–8), and a new natural product, 9-benzoyloxy-gomisin B (9), were isolated from the stems of K. heteroclita. The structures of 1–9 were elucidated by extensive spectroscopic methods, and their absolute configurations were determined by combining CD with ROESY experiments. Additionally, the absolute configuration of 1 ...
DOI:: 10.1016/j.fitote.2017.04.013
: https://doi.org/10.1016/j.fitote.2017.04.013

39. Diterpenoids and Lignans from Cephalotaxus fortunei

Author:: Zhao Jin-Xin; Fan Yao-Yue; Xu Jin-Biao; Gan Li-She; Xu Cheng-Hui; Ding Jian; Yue Jian-Min
Source:: Journal of natural products 2017 v.80 no.2 pp. 356-362
ISSN:: 1520-6025
Subject:: Cephalotaxus; X-ray diffraction; anticarcinogenic activity; biosynthesis; branches; chemical structure; cytotoxicity; diterpenoids; inhibitory concentration 50; leaves; lignans
Abstract:: ... Five new diterpenoids including two Cephalotaxus troponoids (1 and 2), two 17-nor-cephalotane-type diterpenoids (3 and 4), and an abietane-type diterpenoid (5), two new lignans (6 and 7), and a new trisnorneoligan (8) along with eight known compounds were identified from the twigs and leaves of Cephalotaxus fortunei. The structure of 11-hydroxyhainanolidol was revised as 10-hydroxyhainanolidol (9) ...
DOI:: 10.1021/acs.jnatprod.6b00802
: https://doi.org/10.1021/acs.jnatprod.6b00802

40. Effect of Antibiotics and Diet on Enterolactone Concentration and Metabolome Studied by Targeted and Nontargeted LC–MS Metabolomics

Author:: Bolvig Anne K.; Nørskov Natalja P.; Hedemann Mette S.; Foldager Leslie; McCarthy-Sinclair Brendan; Marco Maria L.; Lærke Helle N.; Bach Knudsen Knud E.
Source:: Journal of Proteome Research 2017 v.16 no.6 pp. 2135-2150
ISSN:: 1535-3907
Subject:: antibiotics; blood lipids; diet; epidemiological studies; humans; intestinal microorganisms; lignans; lipid composition; liquid chromatography; low density lipoprotein cholesterol; mass spectrometry; metabolism; metabolites; metabolome; metabolomics; microbial communities; proteome; ribosomal RNA; sequence analysis; swine; swine feeding
Abstract:: ... High plant lignan intake is associated with a number of health benefits, possibly induced by the lignan metabolite enterolactone (ENL). The gut microbiota plays a crucial role in converting dietary lignans into ENL, and epidemiological studies have shown that use of antibiotics is associated with lower levels of ENL. Here we investigate the link between antibiotic use and lignan metabolism in pigs ...
DOI:: 10.1021/acs.jproteome.6b00942
: https://doi.org/10.1021/acs.jproteome.6b00942

41. Enantiomeric 8-O-4′ type neolignans from red raspberry as potential inhibitors of β-amyloid aggregation

Author:: Le Zhou; Li-Li Lou; Wei Wang; Bin Lin; Jun-Ning Chen; Xiao-Bo Wang; Xiao-Xiao Huang; Shao-Jiang Song
Source:: Journal of functional foods 2017 v.37 pp. 322-329
ISSN:: 1756-4646
Subject:: Alzheimer disease; Rubus idaeus; chemical composition; chemical structure; functional foods; lignans; neuroprotective effect; spectral analysis; stereochemistry
Abstract:: ... Red raspberry (Rubus idaeus L.) is an edible fruit-producing species belonging to the Rosaceae family. In our search for potential agents for treating Alzheimer’s disease in this functional food, we decided to investigate the chemical constituents of red raspberry. Four pairs of enantiomeric 8-O-4′-type neolignans (1a/1b–4a/4b), including three new compounds (1a/1b and 2a), were identified from th ...
DOI:: 10.1016/j.jff.2017.08.007
: https://doi.org/10.1016/j.jff.2017.08.007

42. Enterolactone alters FAK-Src signaling and suppresses migration and invasion of lung cancer cell lines

Author:: Shireen Chikara; Kaitlin Lindsey; Pawel Borowicz; Melpo Christofidou-Solomidou; Katie M. Reindl
Source:: BMC complementary and alternative medicine 2017 v.17 no.1 pp. 30
ISSN:: 1472-6882
Subject:: Western blotting; actin; alternative medicine; antineoplastic activity; bioactive compounds; bromides; cell movement; cytoskeleton; drug therapy; fluorescence microscopy; focal adhesions; gene expression; genes; humans; immunocytochemistry; lignans; lung neoplasms; messenger RNA; metastasis; neoplasm cells; phosphorylation; protein synthesis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; tissue repair; tissues; toxicity
Abstract:: ... BACKGROUND: Systemic toxicity of chemotherapeutic agents and the challenges associated with targeting metastatic tumors are limiting factors for current lung cancer therapeutic approaches. To address these issues, plant-derived bioactive components have been investigated for their anti-cancer properties because many of these agents are non-toxic to healthy tissues. Enterolactone (EL) is a flaxseed ...
DOI:: 10.1186/s12906-016-1512-3
PubMed:: 28068967
PubMed Central:: PMC5223372
: https://doi.org/10.1186/s12906-016-1512-3

43. Evaluation of antioxidant activity, total phenolics, total flavonoids and LC–MS/MS characterisation of phenolic constituents in Stachys lavandulifolia

Author:: Soroush Rahimi Khoigani; Ahmad Rajaei; Sayed Amir Hossein Goli
Source:: Natural product research 2017 v.31 no.3 pp. 355-358
ISSN:: 1478-6427
Subject:: Stachys lavandulifolia; absorbance; aldehydes; antioxidant activity; butylated hydroxytoluene; coumaric acids; coumarin; gallic acid; inhibitory concentration 50; iron; lignans; quercetin; stilbenes; tannins
Abstract:: ... The aim of this study was to evaluate phenolics profile and antioxidant activity of Stachys lavandulifolia. Total phenolics (TP), total flavonoids (TF), DPPH• assay (IC50), ferric ion reducing antioxidant power (FRAP) and total antioxidant capacity (TAC) of the methanolic extract were measured. The content of TP, TF, IC50, FRAP and TAC, were obtained as 16.59 gallic acid equiv./g dry matter (DM), ...
DOI:: 10.1080/14786419.2016.1233410
: https://doi.org/10.1080/14786419.2016.1233410

44. Expression in Pichia pastoris and characterization of two novel dirigent proteins for atropselective formation of gossypol

Author:: Isabelle Effenberger; Michael Harport; Jens Pfannstiel; Iris Klaiber; Andreas Schaller
Source:: Applied microbiology and biotechnology 2017 v.101 no.5 pp. 2021-2032
ISSN:: 0175-7598
Subject:: cotton; proteins; biosynthesis; Komagataella pastoris; free radicals; glycosylation; biomimetics; gossypol; Gossypium barbadense; lignans; affinity chromatography; mass spectrometry; batch fermentation
Abstract:: ... We established an efficient fed-batch fermentation process for two novel dirigent proteins from cotton plants, GbDIR2 from Gossypium barbadense and GhDIR3 from G. hirsutum, using the engineered Pichia pastoris GlycoSwitch® SuperMan₅ strain to prevent hyperglycosylation. The two (His)₆-tagged proteins were purified by metal-chelate affinity chromatography and obtained in quantities of 12 and 15 mg ...
DOI:: 10.1007/s00253-016-7997-3
: https://doi.org/10.1007/s00253-016-7997-3

45. Extraction of Flaxseed Oil: A Comparative Study of Three-Phase Partitioning and Supercritical Carbon Dioxide Using Response Surface Methodology

Author:: Nikhil G Kulkarni; Jayaranjan R Kar; Rekha S Singhal
Source:: Food and bioprocess technology 2017 v.10 no.5 pp. 940-948
ISSN:: 1935-5130
Subject:: 2,2-diphenyl-1-picrylhydrazyl; acid value; antioxidant activity; carbon dioxide; cooking fats and oils; economic sustainability; free radical scavengers; iodine value; lignans; linseed; linseed oil; omega-3 fatty acids; oxidative stability; peroxide value; proteins; response surface methodology; solvents; supercritical fluid extraction; ultrasonics
Abstract:: ... Flaxseed has gained significant interest as a source of edible oil that is rich in omega-3 fatty acids, high content of flaxseed proteins and lignans that are known to be therapeutic. Low oxidative stability of flaxseed oil necessitates the use of extraction technologies that are advanced and economically viable than the currently used cold press extraction. This work compares the yield and qualit ...
DOI:: 10.1007/s11947-017-1877-4
: https://doi.org/10.1007/s11947-017-1877-4

46. Extraction of bioactive compounds from sesame (Sesamum indicum L.) defatted seeds using water and ethanol under sub-critical conditions

Author:: Romina Bodoira; Alexis Velez; Alfonsina E. Andreatta; Marcela Martínez; Damián Maestri
Source:: Food chemistry 2017 v.237 pp. 114-120
ISSN:: 0308-8146
Subject:: Sesamum indicum; ambient temperature; bioactive compounds; butylated hydroxytoluene; ethanol; gallic acid; lignans; phenols; quercetin; response surface methodology; seeds; sesame cake; sesame seed
Abstract:: ... Sesame seeds contain a vast array of lignans and phenolic compounds having important biological properties. An optimized method to obtain these seed components was designed by using water and ethanol at high pressure and temperature conditions. The maximum concentrations of lignans, total phenolics, flavonoids and flavonols compounds were achieved at 220°C extraction temperature and 8MPa pressure, ...
DOI:: 10.1016/j.foodchem.2017.05.102
: https://doi.org/10.1016/j.foodchem.2017.05.102

47. Fargesin exerts anti-inflammatory effects in THP-1 monocytes by suppressing PKC-dependent AP-1 and NF-ĸB signaling

Author:: Thu-Huyen Pham; Man-Sub Kim; Minh-Quan Le; Yong-Seok Song; Yesol Bak; Hyung-Won Ryu; Sei-Ryang Oh; Do-Young Yoon
Source:: Phytomedicine 2017 v.24 pp. 96-103
ISSN:: 0944-7113
Subject:: Magnolia biondii; Oriental traditional medicine; Western blotting; anti-inflammatory activity; chemokines; drugs; enzyme-linked immunosorbent assay; fluorescent antibody technique; genes; humans; inducible nitric oxide synthase; interleukin-1beta; lignans; luciferase; messenger RNA; mitogen-activated protein kinase; monocytes; nose; prostaglandin synthase; protein kinase C; protein synthesis; quantitative polymerase chain reaction; sinusitis; transcription factor NF-kappa B; tumor necrosis factor-alpha; viability
Abstract:: ... Fargesin is a lignan from Magnolia fargesii, an oriental medicine used in the treatment of nasal congestion and sinusitis. The anti-inflammatory properties of this compound have not been fully elucidated yet.This study focused on assessing the anti-inflammatory effects of fargesin on phorbal ester (PMA)-stimulated THP-1 human monocytes, and the molecular mechanisms underlying them.Cell viability w ...
DOI:: 10.1016/j.phymed.2016.11.014
: https://doi.org/10.1016/j.phymed.2016.11.014

48. Flavonol glycosides and lignans from the leaves of Opilia amentacea

Author:: Abdulmagid Alabdul Magid; Anaëlle Abdellah; Virginie Pecher; Laure Pasquier; Dominique Harakat; Laurence Voutquenne-Nazabadioko
Source:: Phytochemistry letters 2017 v.21 pp. 84-89
ISSN:: 1874-3900
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Opiliaceae; antioxidant activity; flavonols; glycosides; inhibitory concentration 50; leaves; lignans; mushrooms; spectral analysis
Abstract:: ... Two previously undescribed flavonol tetraglycosides, isorhamnetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (1) and isorhamnetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside (2), along with nine known compounds including seven flavonoids and two lignans, were isolated from the l ...
DOI:: 10.1016/j.phytol.2017.05.023
: https://doi.org/10.1016/j.phytol.2017.05.023

49. Flaxseed and multigrain mixtures in the development of functional biscuits

Author:: Nikolina Čukelj; Dubravka Novotni; Hrvoje Sarajlija; Saša Drakula; Bojana Voučko; Duška Ćurić
Source:: Lebensmittel-Wissenschaft + Technologie 2017 v.86 pp. 85-92
ISSN:: 0023-6438
Subject:: antioxidant activity; baking; barley; bioavailability; biscuits; ingredients; lignans; linseed; lipid peroxidation; markets; oat flour; oats; oxidative stability; phenolic acids; rye; sensory properties; texture; wheat
Abstract:: ... Market reports show an increasing interest for healthy biscuits, with omega-3 and lignan rich flaxseeds being highlighted as key ingredients. Usage of milled flaxseed in comparison to the whole seed might improve bioaccessibility of lignans and omega-3, but also accelerate lipid oxidation, thus diminishing the consumers' acceptability.This research investigated the nutritional (lignans, omega-3, p ...
DOI:: 10.1016/j.lwt.2017.07.048
: https://doi.org/10.1016/j.lwt.2017.07.048

50. Functional characterization of the pinoresinol–lariciresinol reductase-2 gene reveals its roles in yatein biosynthesis and flax defense response

Author:: Cyrielle Corbin; Samantha Drouet; Ivan Mateljak; Lucija Markulin; Cédric Decourtil; Sullivan Renouard; Tatiana Lopez; Joël Doussot; Frédéric Lamblin; Daniel Auguin; Eric Lainé; Elisabeth Fuss; Christophe Hano
Source:: Planta 2017 v.246 no.3 pp. 405-420
ISSN:: 0032-0935
Subject:: Linum usitatissimum; RNA interference; aerial parts; biosynthesis; enantiomers; enzymes; flax; genes; leaves; lignans; methyl jasmonate; quantitative polymerase chain reaction; regulatory sequences; reverse transcriptase polymerase chain reaction; seeds; stress response; tissues; transgenesis
Abstract:: ... MAIN CONCLUSION: This study provides new insights into the biosynthesis regulation and in planta function of the lignan yatein in flax leaves. Pinoresinol–lariciresinol reductases (PLR) catalyze the conversion of pinoresinol into secoisolariciresinol (SECO) in lignan biosynthesis. Several lignans are accumulated in high concentrations, such as SECO accumulated as secoisolariciresinol diglucoside ( ...
DOI:: 10.1007/s00425-017-2701-0
: https://doi.org/10.1007/s00425-017-2701-0

51. Furofuran lignan glucosides from the leaves of Vitex negundo var. cannabifolia

Author:: Yue-Ting Li; Man-Man Li; Jing Sun; Zhi-Xiang Zhu; Yue-Lin Song; Dao-Ran Pang; Jiao Zheng; Yun-Fang Zhao; Peng-Fei Tu; Jun Li
Source:: Natural product research 2017 v.31 no.8 pp. 918-924
ISSN:: 1478-6427
Subject:: Vitex negundo; glucosides; inhibitory concentration 50; leaves; lignans; nitric oxide; spectral analysis; spectroscopy
Abstract:: ... Two new furofuran lignan glucosides, cannabilignin (1) and isocannabilignin (2), together with four known compounds (3 – 6), were isolated from the leaves of Vitex negundo var. cannabifolia . The structures of the isolates were elucidated by analysis of spectroscopic data. Compound 3 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC ...
DOI:: 10.1080/14786419.2016.1255887
: https://doi.org/10.1080/14786419.2016.1255887

52. Furofuran lignans from the Simpson Desert species Eremophila macdonnellii

Author:: Yuen P. Tan; Andrei I. Savchenko; Natasa Broit; Glen M. Boyle; Peter G. Parsons; Craig M. Williams
Source:: Fitoterapia 2017 pp. -
ISSN:: 0367-326X
Subject:: antineoplastic activity; arid zones; breast neoplasms; lignans; phytopharmaceuticals; traditional medicine; Australia
Abstract:: ... The Eremophila plant family, which occurs in the arid zones of Australia, have witnessed extensive investigation, mostly inspired by Aboriginal traditional medicine. A wide and varied biological and phytochemical profile has been reported for over 18 individual species of Australian Eremophila, although E. macdonnellii from the Simpson Desert has not yet been investigated. Isolation and elucidatio ...
DOI:: 10.1016/j.fitote.2017.06.004
: https://doi.org/10.1016/j.fitote.2017.06.004

53. Gardenifolins A–H, Scalemic Neolignans from Gardenia ternifolia: Chiral Resolution, Configurational Assignment, and Cytotoxic Activities against the HeLa Cancer Cell Line

Author:: Tshitenge Dieudonné Tshitenge; Feineis Doris; Awale Suresh; Bringmann Gerhard
Source:: Journal of natural products 2017 v.80 no.5 pp. 1604-1614
ISSN:: 1520-6025
Subject:: Gardenia ternifolia; apoptosis; bark; circular dichroism spectroscopy; cytotoxicity; diastereomers; enantiomers; high performance liquid chromatography; humans; inhibitory concentration 50; lignans; neoplasms; nuclear magnetic resonance spectroscopy; reversed-phase liquid chromatography; stereochemistry
Abstract:: ... From the tropical plant Gardenia ternifolia Schumach. and Thonn. (Rubiaceae), eight stereoisomeric 2,3-dihydrobenzo[b]furan neolignans, named gardenifolins A–H (1a–d and 2a–d), were isolated and fully structurally characterized. Reversed-phase chromatography of a stem bark extract afforded two peaks, viz. mixtures I and II, each one consisting of two diastereomers and their respective enantiomers. ...
DOI:: 10.1021/acs.jnatprod.7b00180
: https://doi.org/10.1021/acs.jnatprod.7b00180

54. Genetic toxicity of Epimedium koreanum Nakai

Author:: Youn-Hwan Hwang; Hey Jin Yang; Nam-Hui Yim; Jin Yeul Ma
Source:: Journal of ethnopharmacology 2017 v.198 pp. 87-90
ISSN:: 0378-8741
Subject:: chromosome aberrations; flavonoids; genotoxicity; glycosides; herbal medicines; lignans; liquid chromatography; mammals; mutagens; mutation; phenolic acids; phytopharmaceuticals; tandem mass spectrometry; traditional medicine; East Asia
Abstract:: ... In Eastern Asia, E. koreanum Nakai (EKN) has traditionally been used as an aphrodisiac herbal medicine. However, there was no available information for its genotoxicity. This study was conducted to evaluate the genotoxic potentials of EKN.The phytochemicals of EKN were identified using liquid chromatography/tandem mass spectrometry (LC/MS/MS). Three standard battery of genotoxicity assay for bacte ...
DOI:: 10.1016/j.jep.2016.11.050
: https://doi.org/10.1016/j.jep.2016.11.050

55. Genistein and enterolactone in relation to Ki‐67 expression and HER2 status in postmenopausal breast cancer patients

Author:: Stefanie Jaskulski; Audrey Y. Jung; Anja Rudolph; Theron Johnson; Kathrin Thöne; Esther Herpel; Peter Sinn; Jenny Chang‐Claude
Source:: Molecular nutrition & food research 2017 v.61 no.11 pp. -
ISSN:: 1613-4125
Subject:: breast neoplasms; cell proliferation; erbB-2 receptor; genistein; lignans; metabolites; patients; plant estrogens; postmenopause; prognosis; regression analysis
Abstract:: ... SCOPE: Phytoestrogens (PE) may improve breast cancer prognosis by modifying tumor prognostic markers, such as cell proliferation marker Ki‐67 and human epidermal growth factor receptor 2 (HER2). Epidemiological evidence linking lignans and isoflavones to Ki‐67 and HER2 is limited. We examined associations between the major metabolites of lignans and isoflavones – enterolactone (ENL) and genistein ...
DOI:: 10.1002/mnfr.201700449
: https://doi.org/10.1002/mnfr.201700449

56. High‐throughput ultra high performance liquid chromatography combined with mass spectrometry approach for the rapid analysis and characterization of multiple constituents of the fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms

Author:: Yue Han; Aihua Zhang; Hui Sun; Yingzhi Zhang; Xiangcai Meng; Guangli Yan; Liang Liu; Xijun Wang
Source:: Journal of separation science 2017 v.40 no.10 pp. 2178-2187
ISSN:: 1615-9306
Subject:: B-lymphocytes; Eleutherococcus senticosus; Oriental traditional medicine; T-lymphocytes; blood serum; chemical composition; flavones; heart; kidneys; lignans; mass spectrometry; medicinal properties; natural killer cells; nutrients; phenolic acids; prototypes; rapid methods; skeleton; spleen; ultra-performance liquid chromatography
Abstract:: ... Acanthopanax senticosus (Rupr. et Maxim.) Harms, a traditional Chinese medicine, has been widely used to improve the function of skeleton, heart, spleen and kidney. This fruit is rich in nutrients, but the chemical constituents of Acanthopanax senticosus fruit are still unclear. A rapid method based on ultra high performance liquid chromatography with time‐of‐flight mass spectrometry was developed ...
DOI:: 10.1002/jssc.201601445
: https://doi.org/10.1002/jssc.201601445

57. Identification of metabolites in human and rat urine after oral administration of Xiao‐Qing‐Long‐Tang granule using ultra high performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

Author:: Lei Zhou; Qiang Zhang; Wen Qi; Shuai Yan; Jialin Qu; Toshiaki Makino; Dan Yuan
Source:: Journal of separation science 2017 v.40 no.18 pp. 3582-3592
ISSN:: 1615-9306
Subject:: alkaloids; biochemical pathways; bronchitis; chemical composition; computer software; essential oils; flavones; ginger; humans; hydroxylation; hypersensitivity; lignans; metabolism; metabolites; nose; oral administration; prototypes; rats; tandem mass spectrometry; ultra-performance liquid chromatography; urine
Abstract:: ... Xiao‐Qing‐Long‐Tang is a traditional Chinese formula used for the treatment of cold syndrome, bronchitis, and nasal allergies for thousands of years. However, the in vivo integrated metabolism of its multiple components and the active chemical constituents of Xiao‐Qing‐Long‐Tang remain unknown. In this study, a method using ultra high performance liquid chromatography coupled with quadrupole time‐ ...
DOI:: 10.1002/jssc.201700423
: https://doi.org/10.1002/jssc.201700423

58. Identification, classification and transcriptional profiles of dirigent domain-containing proteins in sugarcane

Author:: Paula Macedo Nobile; Alexandra Bottcher; Juliana L. S. Mayer; Michael S. Brito; Ivan A. dos Anjos; Marcos Guimarães de Andrade Landell; Renato Vicentini; Silvana Creste; Diego Mauricio Riaño-Pachón; Paulo Mazzafera
Source:: Molecular genetics and genomics 2017 v.292 no.6 pp. 1323-1340
ISSN:: 1617-4615
Subject:: Saccharum officinarum; biosynthesis; cell walls; coniferyl alcohol; culms; fertilizer application; genes; internodes; leaves; lignans; nitrogen; nitrogen fertilizers; phylogeny; pith; proteins; sequence alignment; sucrose; sugarcane; surveys; transcription (genetics); vascular bundles
Abstract:: ... Dirigent (DIR) proteins, encoded by DIR genes, are referred to as “dirigent” because they direct the outcome of the coupling of the monolignol coniferyl alcohol into (+) or (−) pinoresinol, the first intermediates in the enantiocomplementary pathways for lignan biosynthesis. DIR domain-containing or DIR-like proteins are, thus, termed for not having a clear characterization. A transcriptome- and g ...
DOI:: 10.1007/s00438-017-1349-6
: https://doi.org/10.1007/s00438-017-1349-6

59. Identification, in vitro and in vivo Antioxidant Activity, and Gastrointestinal Stability of Lignans from Silver Fir (Abies alba) Wood Extract

Author:: Eva Tavčar Benković; Dušan Žigon; Vladimir Mihailović; Tanja Petelinc; Polona Jamnik; Samo Kreft
Source:: Journal of wood chemistry and technology 2017 v.37 no.6 pp. 467-477
ISSN:: 1532-2319
Subject:: Abies alba; antioxidant activity; ascorbic acid; butylated hydroxytoluene; cell membranes; epigallocatechin gallate; eukaryotic cells; gastrointestinal system; human health; in vitro digestion; in vitro studies; lignans; matairesinol; models; resveratrol; succinic acid; wood; wood extractives; yeasts
Abstract:: ... Lignans are generally known for their beneficial impact on human health. In this study, we found that the water extract of silver fir (Abies alba) wood contains lignans, which constitute approximately 10% of the extract and include isolariciresinol, hydroxymatairesinol, secoisolariciresinol, lariciresinol, pinoresinol, and matairesinol. The antioxidant activity of the extract was measured by sever ...
DOI:: 10.1080/02773813.2017.1340958
: https://doi.org/10.1080/02773813.2017.1340958

60. Impact of extraction techniques on antioxidant capacities and phytochemical composition of polyphenol-rich extracts

Author:: Cecilia Castro-López; Janeth M. Ventura-Sobrevilla; María D. González-Hernández; Romeo Rojas; Juan A. Ascacio-Valdés; Cristóbal N. Aguilar; Guillermo C.G. Martínez-Ávila
Source:: Food chemistry 2017 v.237 pp. 1139-1148
ISSN:: 0308-8146
Subject:: Cassia fistula; Juglans regia; Moringa oleifera; Punica granatum; antioxidant activity; antioxidants; chemical elements; flavonoids; lignans; maceration; phenolic acids; phytopharmaceuticals; plant extracts
Abstract:: ... In this work, impact of extraction methods (maceration, decoction, MAE, and UAE) on TPC, antioxidant activity, and the mass fraction of phenolics in several plant extracts (Punica granatum, Juglans regia, Moringa oleifera, and Cassia fistula) was investigated. The results showed that, despite the nature of matrix, the highest values of TPC in all samples were obtained by MAE as follows: PP (18.92± ...
DOI:: 10.1016/j.foodchem.2017.06.032
: https://doi.org/10.1016/j.foodchem.2017.06.032

61. Impact of lignans on the polyunsaturated fatty acid metabolic processing in a rainbow trout (Oncorhynchus mykiss) cell line

Author:: Julie Mellery; Florian Scalisi; Chloé Bonnineau; Patrick Kestemont; Xavier Rollin; Yvan Larondelle
Source:: Aquaculture 2017 v.476 pp. 106-110
ISSN:: 0044-8486
Subject:: Oncorhynchus mykiss; alpha-linolenic acid; biotransformation; diet; eicosapentaenoic acid; fish; fish feeds; fish oils; hepatocytes; in vitro studies; lignans; linseed; linseed oil; lipid metabolism; omega-3 fatty acids; sesame oil; sesame seed
Abstract:: ... In the context of fish oil replacement by alternative plant-derived oils in the fish feed, the influence of lignans, which are phenolic compounds present at significant concentrations in some plant-derived oils, was investigated on the omega-3 (n-3) fatty acid metabolism of the rainbow trout liver cell line RTL-W1 enriched in alpha-linolenic acid (ALA, 18:3n-3). The major linseed oil lignans, name ...
DOI:: 10.1016/j.aquaculture.2017.04.022
: https://doi.org/10.1016/j.aquaculture.2017.04.022

62. In vitro schistosomicidal activity of the lignan (−)-6,6′-dinitrohinokinin (DNHK) loaded into poly(lactic-co-glycolic acid) nanoparticles against Schistosoma mansoni

Author:: Thaís C. Lima; Rodrigo Lucarini; Priscilla P. Luz; Emerson H. de Faria; Liziane Marçal; Lizandra G. Magalhães; Fernanda R. Badoco; Viviane R. Esperandim; Eduardo F. Molina; Rosangela S. Laurentz; Regiane G. Lima; Wilson R. Cunha; Jairo K. Bastos; Marcio L. Andrade Silva
Source:: Pharmaceutical biology 2017 v.55 no.1 pp. 2270-2276
ISSN:: 1744-5116
Subject:: Schistosoma mansoni; X-ray diffraction; adults; antiparasitic properties; culture media; encapsulation; endocytosis; glycolic acid; in vitro studies; intravenous injection; lethal concentration 50; light scattering; lignans; mortality; nanoparticles; parasites; polymers; praziquantel; scanning electron microscopy; ultraviolet-visible spectroscopy
Abstract:: ... Context: (−)-6,6′-Dinitrohinokinin (DNHK) display remarkable antiparasitic activity and was, therefore, incorporated into a nanoparticle formulation. Objective: Incorporation of DNHK in poly lactic-co-glycolic acid (PLGA) nanoparticles aiming to improve its biological activities. Materials and methods: Synthesis, characterization and incorporation of DNHK into glycolic acid (PLGA) nanoparticles by ...
DOI:: 10.1080/13880209.2017.1405996
PubMed:: 29172838
PubMed Central:: PMC6130564
: https://doi.org/10.1080/13880209.2017.1405996

63. In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans

Author:: Puttaraju Srikantamurthy Yashaswini; Bettadahalli Sadashivaiah; Talahalli Ravichandra Ramaprasad; Sridevi Annapurna Singh
Source:: Journal of nutritional biochemistry 2017 v.41 pp. 151-157
ISSN:: 0955-2863
Subject:: blood serum; catalase; glutathione-disulfide reductase; inflammation; interleukin-1beta; leukotrienes; lignans; lipid peroxidation; liver; metabolic diseases; oxidative stress; rats; sesame oil; superoxide dismutase; therapeutics; tumor necrosis factor-alpha
Abstract:: ... The role of inflammation and oxidative stress is critical during onset of metabolic disorders and this has been sufficiently established in literature. In the present study, we evaluated the effects of sesamol and sesamin, two important bioactive molecules present in sesame oil, on the generation of inflammatory and oxidative stress factors in LPS injected rats. Sesamol and sesamin lowered LPS ind ...
DOI:: 10.1016/j.jnutbio.2016.12.010
: https://doi.org/10.1016/j.jnutbio.2016.12.010

64. Isolation and Identification of the Novel Tubulin Polymerization Inhibitor Bifidenone

Author:: Williams Russell B.; Martin Steven M.; Lawrence Julie A.; Norman Vanessa L.; O’Neil-Johnson Mark; Eldridge Gary R.; Starks Courtney M.
Source:: Journal of natural products 2017 v.80 no.3 pp. 616-624
ISSN:: 1520-6025
Subject:: algorithms; apoptosis; caspases; cytotoxicity; lignans; microtubules; nuclear magnetic resonance spectroscopy; polymerization; screening; structure-activity relationships; tubulin
Abstract:: ... The pursuit of structurally novel compounds has led to the isolation of a series of neolignans (2–6), for which the structures have been determined from microgram quantities using microcryoprobe NMR technology. Compounds 2–6 provided some unexpectedly clear structure–activity relationship data, with compound 2 demonstrating significantly more potency in the in vitro cytotoxicity assay than the oth ...
DOI:: 10.1021/acs.jnatprod.6b00893
: https://doi.org/10.1021/acs.jnatprod.6b00893

65. Isolation of a new β-carboline alkaloid from aerial parts of Triclisia sacleuxii and its antibacterial and cytotoxicity effects

Author:: Fidelis Samita; Charles Otieno Ochieng; Philip Okinda Owuor; Lawrence Onyango Arot Manguro; Jacob Ogweno Midiwo
Source:: Natural product research 2017 v.31 no.5 pp. 529-536
ISSN:: 1478-6427
Subject:: Gram-negative bacteria; Triclisia; adenocarcinoma; aerial parts; alkaloids; antibacterial properties; antibiotics; beta-sitosterol; breast neoplasms; cytotoxicity; humans; hydroxybenzaldehyde; inhibitory concentration 50; lignans; methanol; minimum inhibitory concentration; myricetin; quercetin
Abstract:: ... A new β-carboline alkaloid named sacleuximine A (1) together with known compounds palmatine (2), isotetrandrine (3), trans -N-feruloyltyramine (4), trans -N-caffeoyltyramine (5), yangambin (6), syringaresinol (7), sesamin (8), (+) epi-quercitol (9) , 4-hydroxybenzaldehyde (10), β-sitosterol (11), quercetin 3- O -rutinoside (12) and myricetin 3- O -β-glucose (1→6) α-rhamnoside (13) have been isolat ...
DOI:: 10.1080/14786419.2016.1201666
: https://doi.org/10.1080/14786419.2016.1201666

66. Kudsuphilactone B, a nortriterpenoid isolated from Schisandra chinensis fruit, induces caspase-dependent apoptosis in human ovarian cancer A2780 cells

Author:: Miran Jeong; Hye Mi Kim; Hyun Ji Kim; Jung-Hye Choi; Dae Sik Jang
Source:: Archives of pharmacal research 2017 v.40 no.4 pp. 500-508
ISSN:: 0253-6269
Subject:: 4-hydroxybenzoic acid; B-cell lymphoma; NAD ADP-ribosyltransferase; Schisandra chinensis; acetates; apoptosis; caspase-3; cytotoxicity; dose response; fruits; humans; indole acetic acid; inhibitory concentration 50; lignans; mitogen-activated protein kinase; neoplasm cells; ovarian neoplasms; plant ovary; proteins; protocatechuic acid; uterine neoplasms
Abstract:: ... A phytochemical study on the fruits of Schisandra chinensis led to the isolation and characterization of nineteen compounds. The structures of the isolates were determined to be schizandrin, deoxyschizandrin, angeloylgomisin H, gomisin A, gomisin J, (−)-gomisin L₁, (−)-gomisin L₂, wuweizisu C, gomisin N, meso-dihydroguaiaretic acid, kadsuphilactone B, α-ylangenol, α-ylangenyl acetate, β-chamigrena ...
DOI:: 10.1007/s12272-017-0902-5
: https://doi.org/10.1007/s12272-017-0902-5

67. LC-MS profiling highlights hazelnut (Nocciola di Giffoni PGI) shells as a byproduct rich in antioxidant phenolics

Author:: Milena Masullo; Antonietta Cerulli; Angela Mari; Carla Clisiane de Souza Santos; Cosimo Pizza; Sonia Piacente
Source:: Food research international 2017 v.101 pp. 180-187
ISSN:: 0963-9969
Subject:: 2,2-diphenyl-1-picrylhydrazyl; antioxidant activity; antioxidants; bioactive compounds; byproducts; cultivars; cytotoxicity; economic resources; fibroblasts; flavonoids; hazelnuts; humans; ionization; lignans; liquid chromatography; markets; mass spectrometry; methanol; monitoring; neoplasms; nuclear magnetic resonance spectroscopy; protected designation of origin; quantitative analysis
Abstract:: ... The Italian “Nocciola di Giffoni”, also known as “Tonda di Giffoni”, a labelled Protected Geographical Indication (PGI) product, represents an important economic resource for the Italian market. The methanol (MeOH) extract of “Tonda di Giffoni” shells has been investigated for the phenolic content, assayed by the Folin-Ciocalteu method, and for the antioxidant activity by the 1,1-diphenyl-2-picryl ...
DOI:: 10.1016/j.foodres.2017.08.063
: https://doi.org/10.1016/j.foodres.2017.08.063

68. Larvicidal activity of lignans and alkaloid identified in Zanthoxylum piperitum bark toward insecticide-susceptible and wild Culex pipiens pallens and Aedes aegypti

Author:: Soon-Il Kim; Young-Joon Ahn
Source:: Parasites & vectors 2017 v.10 no.1 pp. 221
ISSN:: 1756-3305
Subject:: Aedes aegypti; Culex pipiens pallens; West Nile virus; Zanthoxylum piperitum; alkaloids; bark; confidence interval; cross resistance; cyfluthrin; deltamethrin; dengue; fenthion; insecticide resistance; larvae; larvicides; lethal concentration 50; lignans; temephos; toxicity
Abstract:: ... BACKGROUND: The yellow fever mosquito, Aedes aegypti, and the common house mosquito, Culex pipiens pallens, transmit dengue fever and West Nile virus diseases, respectively. This study was conducted to determine the toxicity of the three lignans (–)-asarinin, sesamin and (+)-xanthoxylol-γ,γ-dimethylallylether (XDA), and the alkaloid pellitorine from Zanthoxylum piperitum (Rutaceae) bark to third-i ...
DOI:: 10.1186/s13071-017-2154-0
PubMed:: 28472971
PubMed Central:: PMC5418860
: https://doi.org/10.1186/s13071-017-2154-0

69. Lignan glycosides from the Rhizomes of Smilax trinervula and their Biological activities

Author:: Jicheng Shu; Fang Liang; Genhua Zhu; Xing Liu; Jiangli Yu; Huilian Huang
Source:: Phytochemistry letters 2017 v.20 pp. 1-8
ISSN:: 1874-3900
Subject:: Smilax; cytotoxicity; electrospray ionization mass spectrometry; glycosides; humans; inhibitory concentration 50; lignans; neoplasm cells; nuclear magnetic resonance spectroscopy; rhizomes; spectral analysis
Abstract:: ... Phytochemical investigation of the rhizomes of Smilax trinervula led to isolation and structure elucidation of eight lignan glycosides, including five new lignans, namely, (7S, 8R, 8′R)-4, 4′, 9-trihydroxy-3, 3′, 5, 5′-tetramethoxy-7, 9′-epoxylignan-7′-one 4′-O-β-d-glucopyranoside (1), (7S, 8R, 8′R)-4, 4′, 9-trihydroxy-3, 3′, 5, 5′-tetramethoxy-7, 9′-epoxylignan-7′-one 4-O-β-d- glucopyranoside (2) ...
DOI:: 10.1016/j.phytol.2017.03.002
: https://doi.org/10.1016/j.phytol.2017.03.002

70. Lignans and diterpenes isolated from Tirpitzia ovoidea and their biological activities

Author:: Xue-Yan YANG; Yi-Fan ZHANG; Li-Jia LIU; Yi WANG; Ming-Ying SHANG; Feng XU; Guang-Xue LIU; Shao-Qing CAI
Source:: Chinese journal of natural medicines 2017 v.15 no.12 pp. 938-943
ISSN:: 1875-5364
Subject:: Linaceae; Oriental traditional medicine; aerial parts; anti-inflammatory activity; cell lines; cytotoxicity; diterpenoids; ethanol; ethyl acetate; inflammation; inhibitory concentration 50; lignans; macrophages; mice; models; nitric oxide; spectral analysis
Abstract:: ... A new lignan, tirpitzin A (17) together with 20 known compounds (1–16, and 18–21) were isolated from the ethyl acetate soluble fraction of ethanol extract of the aerial parts of Tirpitzia ovoidea. The structure of new compound was elucidated by means of spectroscopic analysis. Of the known compounds, 7–21 were isolated from Linaceae family for the first time. The pharmacological activity of the cr ...
DOI:: 10.1016/S1875-5364(18)30010-4
: https://doi.org/10.1016/S1875-5364(18)30010-4

71. Lignans and indole alkaloids from the seeds of Centaurea vlachorum Hartvig (Asteraceae), growing wild in Albania and their biological activity

Author:: Entela Hodaj; Olga Tsiftsoglou; Sokol Abazi; Dimitra Hadjipavlou-Litina; Diamanto Lazari
Source:: Natural product research 2017 v.31 no.10 pp. 1195-1200
ISSN:: 1478-6427
Subject:: Centaurea; linoleic acid; seeds; bioactive properties; serotonin; 2,2-diphenyl-1-picrylhydrazyl; linoleate 13S-lipoxygenase; soybeans; free radical scavengers; secondary metabolites; indole alkaloids; lignans; in vitro studies; peroxidation; matairesinol; Albania
Abstract:: ... The present phytochemical investigation of the seeds of Centaurea vlachorum led to the isolation and characterisation of four compounds including two indole alkaloids N-(p-coumaroyl) serotonin (1) and moschamine (2) and two dibenzylbutyrolactone lignans matairesinol (3) and arctiin (4). This is the first report on the isolation of non-volatile secondary metabolites from C. vlachorum. The chemataxo ...
DOI:: 10.1080/14786419.2016.1226823
: https://doi.org/10.1080/14786419.2016.1226823

72. Lignans from guaiac resin decrease nitric oxide production in interleukin 1β-treated hepatocytes

Author:: Yuki Nakano; Masaaki Nasu; Mana Kano; Hiroshi Kameoka; Tetsuya Okuyama; Mikio Nishizawa; Yukinobu Ikeya
Source:: Natural medicines 2017 v.71 no.1 pp. 190-197
ISSN:: 1340-3443
Subject:: Guaiacum officinale; anti-inflammatory activity; drugs; heartwood; hepatocytes; interleukin-1beta; lignans; monitoring; nitric oxide; rats
Abstract:: ... Guaiac resin, extracted from the heartwood of Guaiacum officinale L. or G. sanctum L., is speculated to have anti-inflammatory effects. Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1β (IL-1β). Six lignans were purified from guaiac resin and identified as: dehy ...
DOI:: 10.1007/s11418-016-1048-3
: https://doi.org/10.1007/s11418-016-1048-3

73. Lignans from the shed trunk barks of the critically endangered plant Abies beshanzuensis and their anti-neuroinflammatory activities

Author:: Chang-Ling Hu; Juan Xiong; Peng Xu; Ke-Jun Cheng; Guo-Xun Yang; Jin-Feng Hu
Source:: Natural product research 2017 v.31 no.12 pp. 1358-1364
ISSN:: 1478-6427
Subject:: Abies; inhibitory concentration 50; lignans; mice; nitric oxide; plants (botany); spectral analysis
Abstract:: ... During a further and comprehensive phytochemical investigation on the shed trunk barks of the critically endangered plant Abies beshanzuensis , one new (1) and ten known (2 – 11) lignans with diverse structures were isolated. On the basis of spectroscopic methods, the new structure was established to be (7 S ,8 R ,8′ R)-4′-methoxyl- α -conidendrin (1). Among the isolated lignans, (−)-matairesinol ...
DOI:: 10.1080/14786419.2016.1247082
: https://doi.org/10.1080/14786419.2016.1247082

74. Lipoxygenase-inhibiting lignans from Clematis mandshurica

Author:: Qiang Fu; Chuang Zhou; Yu Ma; Min Yang; Hai-Mei Yuan; Jiang Chen; Pei-Xi Liu
Source:: Journal of Asian natural products research 2017 v.19 no.9 pp. 884-889
ISSN:: 1477-2213
Subject:: linoleate 13S-lipoxygenase; Clematis terniflora var. mandshurica; lignans; hydrolysis; spectral analysis; rhizomes; ethanol; roots
Abstract:: ... The EtOH extract of the roots and rhizomes of Clematis mandshurica afforded two new lignans clemomanshurinane C (1) and clemomanshurinane D (2), and three known compounds (3–5). Their structures were elucidated on the basis of spectroscopic means and hydrolysis products. All compounds displayed moderate inhibitory activity against enzyme lipoxygenase. ...
DOI:: 10.1080/10286020.2016.1251419
: https://doi.org/10.1080/10286020.2016.1251419

75. Mass spectrometry-based analysis of whole-grain phytochemicals

Author:: Ville Mikael Koistinen; Kati Hanhineva
Source:: Critical reviews in food science and nutrition 2017 v.57 no.8 pp. 1688-1709
ISSN:: 1549-7852
Subject:: alkylresorcinols; barley; benzoxazinoids; flavonoids; lignans; liquid chromatography; mass spectrometry; noninfectious diseases; oats; phytosterols; risk; rye; spectral analysis; wheat; whole grain foods
Abstract:: ... Whole grains are a rich source of several classes of phytochemicals, such as alkylresorcinols, benzoxazinoids, flavonoids, lignans, and phytosterols. A high intake of whole grains has been linked to a reduced risk of some major noncommunicable diseases, and it has been postulated that a complex mixture of phytochemicals works in synergy to generate beneficial health effects. Mass spectrometry, esp ...
DOI:: 10.1080/10408398.2015.1016477
: https://doi.org/10.1080/10408398.2015.1016477

76. Metabolic signatures altered by in vitro temperature stress in Ajuga bracteosa Wall. ex. Benth.

Author:: Rehana Rani; Mubarak Ali Khan; Waqas Khan Kayani; Sami Ullah; Ijaz Naeem; Bushra Mirza
Source:: Acta physiologiae plantarum 2017 v.39 no.4 pp. 97
ISSN:: 0137-5881
Subject:: Ajuga; biosynthesis; caffeic acid; cinnamic acid; electrospray ionization mass spectrometry; flavonoids; glucose; glutamine; histidine; ions; lignans; methionine; pentose phosphate cycle; phosphates; principal component analysis; secondary metabolites; serine; temperature; tricarboxylic acid cycle
Abstract:: ... To elucidate how biosynthesis of plant metabolites is affected by temperature, metabolite profiles from in vitro regenerated plants raised under different temperature regimes of 10, 15 °C, 20 °C, 25 °C and 30 °C were obtained using electrospray ionization mass spectrometry (ESI-MS), and principal component analysis (PCA) was carried out to identify key metabolites. Several bin masses were detected ...
DOI:: 10.1007/s11738-017-2394-9
: https://doi.org/10.1007/s11738-017-2394-9

77. Methyl caffeate and some plant constituents inhibit age-related inflammation: effects on senescence-associated secretory phenotype (SASP) formation

Author:: Hyun Lim; Byung Kyu Park; Sook Young Shin; Yong Soo Kwon; Hyun Pyo Kim
Source:: Archives of pharmacal research 2017 v.40 no.4 pp. 524-535
ISSN:: 0253-6269
Subject:: anthraquinones; caffeic acid; chemokine CXCL1; fibroblasts; flavonoids; gene expression; granulocyte-macrophage colony-stimulating factor; inflammation; interleukin-1alpha; interleukin-1beta; interleukin-6; interleukin-8; lignans; messenger RNA; phenotype; phenylpropanoids; transcription factor NF-kappa B
Abstract:: ... During aging, cells secrete molecules called senescence-associated secretory phenotype (SASP). They constitute chronic low-grade inflammation environment to adjacent cells and tissues. In order to find inhibiting agents of SASP formation, 113 plant constituents were incubated with BJ fibroblasts for 6 days after treatment with bleomycin. Several plant constituents showed considerable inhibition of ...
DOI:: 10.1007/s12272-017-0909-y
: https://doi.org/10.1007/s12272-017-0909-y

78. Micro-matrix solid-phase dispersion coupled with MEEKC for quantitative analysis of lignans in Schisandrae Chinensis Fructus using molecular sieve TS-1 as a sorbent

Author:: Chu Chu; Mengmeng Wei; Shan Wang; Liqiong Zheng; Zheng He; Jun Cao; Jizhong Yan
Source:: Journal of chromatography 2017 v.1063 pp. 174-179
ISSN:: 1570-0232
Subject:: chromatography; grinding; lignans; methanol; oils; quantitative analysis; solid phase extraction; solvents; sorbents
Abstract:: ... A simple and effective method was developed for determining lignans in Schisandrae Chinensis Fructus by using a micro-matrix solid phase dispersion (MSPD) technique coupled with microemulsion electrokinetic chromatography (MEEKC). Molecular sieve, TS-1, was applied as a solid supporting material in micro MSPD extraction for the first time. Parameters that affect extraction efficiency, such as type ...
DOI:: 10.1016/j.jchromb.2017.08.024
: https://doi.org/10.1016/j.jchromb.2017.08.024

79. Musts with Increased Lignan Content Through Addition of Lignan Extracts

Author:: Josef Balík; Pavel Híc; Jana Kulichová; Pavla Novotná; Jan Tříska; Naděžda Vrchotová; Jan Strohalm; Danuše Lefnerová; Milan Houška
Source:: Food and bioprocess technology 2017 v.10 no.7 pp. 1367-1373
ISSN:: 1935-5130
Subject:: Picea; antioxidant activity; ethanol; grape must; grapes; knots; lignans; polyphenols; storage time; sugars
Abstract:: ... Red and white grape musts were enriched with 7-hydroxymatairesinol (HMR), which is the main lignan contained in spruce knots. Lignan enrichment was achieved by adding a spruce knot ethanol extract. Enriched musts were stored for 12 months and during storage must samples were periodically analyzed for HMR and alpha-conidendrin content, antioxidant activity, total polyphenols, and anti-mutagenicity. ...
DOI:: 10.1007/s11947-017-1911-6
: https://doi.org/10.1007/s11947-017-1911-6

80. Neolignan and megastigmane glucosides from the aerial parts of Isodon japonicus with cell protective effects on BaP-induced cytotoxicity

Author:: Takahiro Matsumoto; Seikou Nakamura; Souichi Nakashima; Tomoe Ohta; Keiko Ogawa; Masashi Fukaya; Junko Tsukioka; Tomohiro Hasei; Tetsushi Watanabe; Hisashi Matsuda
Source:: Phytochemistry 2017 v.137 pp. 101-108
ISSN:: 0031-9422
Subject:: aerial parts; chemical structure; cytotoxicity; glucosides; lignans; nuclear magnetic resonance spectroscopy; protective effect; spectral analysis; Japan
Abstract:: ... Six neolignan glucosides, named isodonosides I–VI, and a megastigmane glucoside named isodonmegastigmane I, were isolated together with 15 known compounds from the methanolic extract of aerial parts of Isodon japonicus cultivated in Tokushima, Japan. The chemical structures of the compounds were elucidated based on their MS and NMR spectroscopic analysis. The absolute configurations of the neolign ...
DOI:: 10.1016/j.phytochem.2017.02.007
: https://doi.org/10.1016/j.phytochem.2017.02.007

81. Neolignan and monoterpene glycoside from the seeds of Pharbitis nil

Author:: Seoung Rak Lee; Eunjung Moon; Ki Hyun Kim
Source:: Phytochemistry letters 2017 v.20 pp. 98-101
ISSN:: 1874-3900
Subject:: Ipomoea nil; anti-inflammatory activity; chemical structure; cytotoxicity; ethanol; glycosides; inhibitory concentration 50; lignans; lipopolysaccharides; mice; monoterpenoids; nitric oxide; nuclear magnetic resonance spectroscopy; seeds; spectral analysis
Abstract:: ... Phytochemical investigation of an EtOH extract of Pharbitis nil seeds (Convolvulaceae) resulted in the isolation and identification of a new neolignan, 7R,8S-threo-dihydroxydehydrodiconiferyl alcohol (1), and a new monoterpene glycoside, (3Z,7S)-7-hydroxy-3,7-dimethyl-3,8-octadienyl-β-d-glucopyranoside (2), together with a known compound, ethyl α-l-arabinofuranoside (3). The chemical structures of ...
DOI:: 10.1016/j.phytol.2017.04.019
: https://doi.org/10.1016/j.phytol.2017.04.019

82. Neolignans isolated from Nectandra leucantha induce apoptosis in melanoma cells by disturbance in mitochondrial integrity and redox homeostasis

Author:: Fernanda S. de Sousa; Simone S. Grecco; Natalia Girola; Ricardo A. Azevedo; Carlos R. Figueiredo; João Henrique G. Lago
Source:: Phytochemistry 2017 v.140 pp. 108-117
ISSN:: 0031-9422
Subject:: DNA; Lewis bases; Nectandra; actin; apoptosis; benzene; branches; caspase-3; cytotoxicity; fractionation; homeostasis; inhibitory concentration 50; lignans; melanoma; membrane potential; metabolites; mice; mitochondria; mitochondrial membrane; phosphatidylserines
Abstract:: ... Six neolignans including three previously undescribed metabolites: 1-[(7R)-hydroxy-8-propenyl]-3-[3′-methoxy-1′-(8′-propenyl)-phenoxy]-4,5-dimethoxybenzene, 4-hydroxy-5-methoxy-3-[3′-methoxy-1′-(8′-propenyl)phenoxy]-1-(7-oxo-8-propenyl)benzene and 4,5-dimethoxy-3-[3′-methoxy-1′-(8′-propenyl)phenoxy]-1-(7-oxo-8-propenyl)benzene were isolated from twigs of Nectandra leucantha Nees & Mart (Lauraceae) ...
DOI:: 10.1016/j.phytochem.2017.04.024
: https://doi.org/10.1016/j.phytochem.2017.04.024

83. Neuroprotective Lignans from the Fruits of Schisandra bicolor var. tuberculata

Author:: Liu Ye; Yu Heng-Yi; Wang Yan-Mei; Tian Tian; Wu Wen-Ming; Zhou Ming; Meng Xiang-Gao; Ruan Han-Li
Source:: Journal of natural products 2017 v.80 no.4 pp. 1117-1124
ISSN:: 1520-6025
Subject:: Schisandra; X-ray diffraction; chemical structure; fruits; hydrogen peroxide; irradiation; lignans; models; neuroprotective effect; spectral analysis
Abstract:: ... Nine new lignans (1–9) and ten known analogues (10–19) were isolated from the fruits of Schisandra bicolor var. tuberculata. The structures of compounds 1–9 were established on the basis of spectroscopic data analysis. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction analysis with Cu Kα irradiation techniques, and the absolute configurations of compounds ...
DOI:: 10.1021/acs.jnatprod.7b00035
: https://doi.org/10.1021/acs.jnatprod.7b00035

84. A New Insecticidal Lignan Glucoside from Galium verum

Author:: Jia Chen; Chun-Chao Zhao; Jian-Hua Shao; Ju-Di Fan; Xu-Hua Huang
Source:: Chemistry of natural compounds 2017 v.53 no.4 pp. 626-628
ISSN:: 0009-3130
Subject:: Galium verum; Helicoverpa armigera; Scorpiones; chemical structure; glucosides; insecticidal properties; lignans; mortality; poisoning; scorpion venoms; spectral analysis; stomach; toxicity
Abstract:: ... A new lignan glucoside, galiveroside A (1), and seven known compounds (2–8), were isolated from Galium verum L. The structure of 1 was elucidated on the basis of extensive spectroscopic analyses. Compound 1, at the concentration of 5 mg/mL, showed insecticide activity to 3 age cotton bollworm with a mortality of 16.3% through stomach poisoning. When combined with a recombinant scorpion toxin rLqh ...
DOI:: 10.1007/s10600-017-2075-3
: https://doi.org/10.1007/s10600-017-2075-3

85. A New Lignan Glucoside from Cyclea racemosa

Author:: Jian-Hua Shao; Xue-Wei Zhang; Zi-Ling Dong; Si-Hui Li; Ben-Jie Miao; Ke-Zhi Cheng
Source:: Chemistry of natural compounds 2017 v.53 no.6 pp. 1025-1027
ISSN:: 0009-3130
Subject:: Cyclea; chemical structure; glucosides; lignans; spectral analysis
Abstract:: ... A new lignan glucoside 1, along with two known lignans (2, 3), was isolated from Cyclea racemosa Oliv. Its structure was elucidated as (+)-7′-methoxylariciresinol 4-O-β-D-glucopyranoside on the basis of extensive spectroscopic analyses. ...
DOI:: 10.1007/s10600-017-2193-y
: https://doi.org/10.1007/s10600-017-2193-y

86. A New Lignan from Cinnamomum burmanii

Author:: L. T. Yuan; C. L. Kao; C. T. Chen; H. T. Li; C. Y. Chen
Source:: Chemistry of natural compounds 2017 v.53 no.4 pp. 623-625
ISSN:: 0009-3130
Subject:: Cinnamomum; chemistry; lignans; roots; spectroscopy
Abstract:: ... Investigation of the roots extract of Cinnamomum burmanii (Lauraceae) led to the isolation of one new lignan, cinnaburmanin A (1). Its structure was determined through in-depth spectroscopic and mass-spectrometric analyses. ...
DOI:: 10.1007/s10600-017-2074-4
: https://doi.org/10.1007/s10600-017-2074-4

87. A New Neolignan from the Aerial Parts of Prunella vulgaris var. lilacina

Author:: Changyeol Lee; Sang Hee Shim
Source:: Chemistry of natural compounds 2017 v.53 no.1 pp. 24-27
ISSN:: 0009-3130
Subject:: 4-hydroxybenzoic acid; Prunella vulgaris; aerial parts; alcohols; chemistry; flavonoids; lignans; steroids; triterpenoids
Abstract:: ... Prunella vulgaris is known to contain pentacyclic triterpenoids, flavonoids, phenolic compounds, and steroids. Among the triterpenoids, the oleanane-type, ursane-type, and lupane-type triterpenoids have been known to be predominant. Our phytochemical study led to the isolation of a new neolignan, 9′-O-butyl dehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (1), together with four known compounds, ...
DOI:: 10.1007/s10600-017-1902-x
: https://doi.org/10.1007/s10600-017-1902-x

88. New isobaric lignans from Refined Olive Oils as quality markers for Virgin Olive Oils

Author:: Lorenzo Cecchi; Marzia Innocenti; Fabrizio Melani; Marzia Migliorini; Lanfranco Conte; Nadia Mulinacci
Source:: Food chemistry 2017 v.219 pp. 148-157
ISSN:: 0308-8146
Subject:: bleaching; chemical structure; chromatography; deodorization; extra-virgin olive oil; lignans; oil refining; Italy; Spain; Tunisia
Abstract:: ... Herein we describe the influence of olive oil refining processes on the lignan profile. The detection of new isobaric lignans is suggested to reveal frauds in commercial extra-Virgin Olive Oils. We analyzed five commercial olive oils by HPLC-DAD-TOF/MS to evaluate their lignan content and detected, for the first time, some isobaric forms of natural (+)-pinoresinol and (+)-1-acetoxypinoresinol. The ...
DOI:: 10.1016/j.foodchem.2016.09.132
: https://doi.org/10.1016/j.foodchem.2016.09.132

89. New lignan glycosides from Justicia procumbens

Author:: Hong Jin; Shu Yang; Jun-Xing Dong
Source:: Journal of Asian natural products research 2017 v.19 no.1 pp. 1-8
ISSN:: 1477-2213
Subject:: Justicia procumbens; glycosides; lignans; mass spectrometry; nuclear magnetic resonance spectroscopy
Abstract:: ... Four new lignan glycosides (1 – 4), named procumbenosides I, K, L, and M, together with cleistanthin B (5) reported for the first time in the genus Justicia , and 5 other known arylnaphthalene lignan glycosides (6 – 10) were isolated from the whole plant of Justicia procumbens . The structures of the new compounds were elucidated by extensive one-dimensional (1D) and two-dimensional (2D) NMR exper ...
DOI:: 10.1080/10286020.2016.1241771
: https://doi.org/10.1080/10286020.2016.1241771

90. New neolignan glycoside from the root of Aralia echinocaulis Hand. -Mazz

Author:: Yunzhi Li; Hui Cheng; Ren Yue; Mengmeng Duan; Mingdong Liu
Source:: Natural product research 2017 v.31 no.9 pp. 1047-1051
ISSN:: 1478-6427
Subject:: Aralia; chemical structure; ionization; lignans; nuclear magnetic resonance spectroscopy; saponins
Abstract:: ... A phytochemical investigation was carried out to the root of Aralia echinocauis , and a new neolignan glycoside, 3-{3,5-dimethoxy-4β- d -Glucopyranoside-2-[3-(3-β- d -Glucopyranoside-4-methoxy-phenyl)-allyl]-phenyl}-prop-2-en-1-ol (1), together with a known saponin, araliasaponin II (2) for the first time was obtained . The chemical structure of compound 1 was identified mainly by the analysis of ...
DOI:: 10.1080/14786419.2016.1269095
: https://doi.org/10.1080/14786419.2016.1269095

91. O papel da linhaça como agente redutor de colesterol e perde de peso

Author:: Vanessa Tonetta; Bibiana Paula Dambrós; Elisandra Minotto; Nei Carlos Santin
Source:: Revista brasileira de obesidade, nutrição e emagrecimento 2017 v.11 no.63 pp. 159-167
ISSN:: 1981-9919
Subject:: Linum usitatissimum; cardiovascular diseases; cholesterol; energy; functional foods; ingestion; intestines; lignans; linolenic acid; linseed; menopause; physical activity; questionnaires; satiety; weight loss
Abstract:: ... A semente de linhaça (Linun usitatissimum L.) é amplamente utilizada pela população como um alimento funcional, é rica em ácido-linolênico, lignanas e fibras dietéticas, os quais estão relacionados ao controle do colesterol, aumento da saciedade e consequente perda de peso, além de influenciar na redução da incidência de diversas patologias, como as doenças cardiovasculares. O objetivo deste estud ...

92. Phenolic and volatile compounds of Neb Jmel olive oil cultivar according to their geographical origin using chemometrics

Author:: Amir Ben Mansour; Fatma Chtourou; Wahid Khbou; Guido Flamini; Mohamed Bouaziz
Source:: European food research & technology 2017 v.243 no.3 pp. 403-418
ISSN:: 1438-2377
Subject:: alcohols; aldehydes; chemometrics; cultivars; esters; extra-virgin olive oil; flavonoids; headspace analysis; high performance liquid chromatography; ketones; lignans; oxidative stability; phenolic acids; provenance; secoiridoids; solid phase microextraction; volatile compounds
Abstract:: ... This paper reports the quality indices, the volatile components, phenolic compounds and the oxidative stability of monovarietal Tunisian cultivar (cv. Neb Jmel) extra-virgin olive oils cultivated in eight regions. Headspace solid-phase microextraction and HPLC–DAD were applied to analyze and quantify the volatile and phenolic compounds of the obtained extra-virgin olive oils. Twenty compounds have ...
DOI:: 10.1007/s00217-016-2754-5
: https://doi.org/10.1007/s00217-016-2754-5

93. Phenylpropanoids from the fruits of Nicandra physaloides and their anti-inflammatory activities

Author:: Bing You Yang; Yan Liu; Hai Bing Jiang; Zhen Peng Xu; Rui Guo; Rui Wang; Xiao Mao Li; Hai Xue Kuang
Source:: Natural product research 2017 v.31 no.22 pp. 2634-2640
ISSN:: 1478-6427
Subject:: Nicandra; anti-inflammatory activity; fruits; inhibitory concentration 50; mass spectrometry; nitric oxide; nuclear magnetic resonance spectroscopy; phenylpropanoids
Abstract:: ... Twenty-one phenylpropanoids, including 1 new (1) and 20 known phenylpropanoids (2–21), were isolated and identified from the fruits of Nicandra physaloides . The structures of these compounds were established by 1D and 2D NMR spectra referring to the literatures, together with mass spectrometry. It was found that the isolated compounds, except for 7 , 18 and 19 , showed the different levels of inh ...
DOI:: 10.1080/14786419.2017.1289202
: https://doi.org/10.1080/14786419.2017.1289202

94. Physiological effects of γ-linolenic acid and sesamin on hepatic fatty acid synthesis and oxidation

Author:: Takashi Ide; Haruka Iwase; Saaya Amano; Saki Sunahara; Ayuka Tachihara; Minako Yagi; Tsuyoshi Watanabe
Source:: Journal of nutritional biochemistry 2017 v.41 pp. 42-55
ISSN:: 0955-2863
Subject:: acyl coenzyme A; beta oxidation; blood lipids; dietary supplements; evening primrose oil; experimental diets; fatty acid metabolism; gamma-linolenic acid; lignans; linoleic acid; lipoproteins; malic enzyme; messenger RNA; organelles; oxidation; palm oils; rats; safflower oil; saturated fats
Abstract:: ... Interrelated effects of γ-linolenic acid (GLA) and sesamin, a sesame lignan, on hepatic fatty acid synthesis and oxidation were examined. Rats were fed experimental diets supplemented with 0 or 2 g/kg sesamin (1:1 mixture of sesamin and episesamin) and containing 100 g/kg of palm oil (saturated fat), safflower oil rich in linoleic acid, or oil of evening primrose origin containing 43% GLA (GLA oil ...
DOI:: 10.1016/j.jnutbio.2016.12.001
: https://doi.org/10.1016/j.jnutbio.2016.12.001

95. Phytochemical analysis of bark from Helietta apiculata Benth and antimicrobial activities

Author:: Tanize S. Fernandes; Daniele Copetti; Gabriele do Carmo; Alexandre T. Neto; Marcelo Pedroso; Ubiratan F. Silva; Marco A. Mostardeiro; Robert E. Burrow; Ionara I. Dalcol; Ademir F. Morel
Source:: Phytochemistry 2017 v.141 pp. 131-139
ISSN:: 0031-9422
Subject:: Helietta; X-radiation; alkaloids; antimicrobial properties; bark; cinnamic acid; coumarin; crystal structure; lignans; quinolones; spectroscopy
Abstract:: ... Extraction and characterization of natural products from the bark of the trunk of Helietta apiculata Benth (Rutaceae) afforded nine alkaloids, eight furoquinoline and one quinolone, limonine, three cinnamic acid derivatives, three neolignans, tetracosanoic acid, six coumarins, of which apiculin A and apiculin B (neolignans), and tanizin (coumarin) are previously undescribed compounds. The structur ...
DOI:: 10.1016/j.phytochem.2017.05.017
: https://doi.org/10.1016/j.phytochem.2017.05.017

96. Phytochemical study of Joannesia princeps Vell. (Euphorbiaceae) leaves

Author:: César Muñoz Camero; Abeer Temraz; Alessandra Braca; Marinella De Leo
Source:: Biochemical systematics and ecology 2017 v.70 pp. 69-72
ISSN:: 0305-1978
Subject:: Euphorbiaceae; chemotaxonomy; flavonoids; glycosylation; leaves; lignans; metabolites; methanol; monoterpenoids; spectral analysis
Abstract:: ... A phytochemical study of chloroform-methanol and methanol extracts of Joannesia princeps Vell. Leaves led to the isolation of twenty eight compounds, including two α-ionones (2, 5), three glycosylated monoterpenes (1, 3, 4), eight phenolic compounds (6, 8, 9, 12, 14, 17, 18, 24), two gallotannins (10, 11), twelve flavonoids (7, 15, 16, 19, 20–23, 25–28), and one lignan (13). The structural charact ...
DOI:: 10.1016/j.bse.2016.10.023
: https://doi.org/10.1016/j.bse.2016.10.023

97. Phytochemical study of Pilosocereus pachycladus and antibiotic-resistance modifying activity of syringaldehyde

Author:: Severino Gonçalves de Brito-Filho; Jéssica Karina da Silva Maciel; Yanna Carolina Ferreira Teles; Milen Maria Magalhães de Souza Fernandes; Otemberg Souza Chaves; Maria Denise Leite Ferreira; Pedro Dantas Fernandes; Leonardo P. Felix; Isis Caroline da Silva Cirino; José Pinto Siqueira-Júnior; Raimundo Braz-Filho; Maria de Fátima Vanderlei de Souza
Source:: Revista Brasileira de Farmacognosia 2017 v.27 no.4 pp. 453-458
ISSN:: 0102-695X
Subject:: Pilosocereus; Staphylococcus aureus; antibacterial properties; antibiotic resistance; antibiotics; bacteria; benzaldehyde; caatinga; chlorophyll; chromatography; ecoregions; ethidium; fatty acids; inflammation; lignans; minimum inhibitory concentration; norfloxacin; secondary metabolites; spectroscopy; steroids; traditional medicine; transporters
Abstract:: ... Pilosocereus pachycladus F. Ritter, Cactaceae, popularly known as “facheiro”, is used as food and traditional medicine in Brazilian caatinga ecoregion. The plant is used to treat prostate inflammation and urinary infection. The present work reports the first secondary metabolites isolated from P. pachycladus. Therefore, the isolated compound 4-hydroxy-3,5-dimethoxy benzaldehyde (syringaldehyde) wa ...
DOI:: 10.1016/j.bjp.2017.06.001
: https://doi.org/10.1016/j.bjp.2017.06.001

98. Phytochemicals and biological activities of Artemisia sieversiana

Author:: Shi-Jun Liu; Zhi-Xin Liao; Zhi-Shu Tang; Chun-Li Cui; Hong-Bo Liu; Yan-Ni Liang; Yu Zhang; Huan-Xian Shi; Yao-Run Liu
Source:: Phytochemistry reviews 2017 v.16 no.3 pp. 441-460
ISSN:: 1568-7767
Subject:: Artemisia; alkaloids; antioxidant activity; chemical composition; diterpenoids; flavonoids; lignans; phytopharmaceuticals; sesquiterpenoids; steroids
Abstract:: ... This review discusses a whole plant’s chemical nature and biological effects of Artemisia sieversiana Ehrhart ex willd (ASS). Several types of chemical compositions have been isolated from A. sieversiana, including 26 terpenoids (21 guaiane-type sesquiterpenes, 3 germacrane-type sesquiterpenes, 1 muurolane-type sesquiterpene, and 1 diterpenoid), 16 sesamin-type lignans, 9 flavonoids, 3 steroids, a ...
DOI:: 10.1007/s11101-016-9475-z
: https://doi.org/10.1007/s11101-016-9475-z

99. Pinus pinaster Knot: A Source of Polyphenols against Plasmopara viticola

Author:: Gabaston Julien; Richard Tristan; Cluzet Stéphanie; Palos Pinto Antonio; Dufour Marie-Cécile; Corio-Costet Marie-France; Mérillon Jean-Michel
Source:: Journal of agricultural and food chemistry 2017 v.65 no.40 pp. 8884-8891
ISSN:: 1520-5118
Subject:: Pinus pinaster; Plasmopara viticola; antifungal properties; biomass; byproducts; caffeic acid; ferulic acid; lignans; matairesinol; mildews; nuclear magnetic resonance spectroscopy; polyphenols; pterostilbene; taxifolin; zoospores
Abstract:: ... Pine knot extract from Pinus pinaster byproducts was characterized by UHPLC-DAD-MS and NMR. Fourteen polyphenols divided into four classes were identified as follows: lignans (nortrachelogenin, pinoresinol, matairesinol, isolariciresinol, secoisolariciresinol), flavonoids (pinocembrin, pinobanksin, dihydrokaempferol, taxifolin), stilbenes (pinosylvin, pinosylvin monomethyl ether, pterostilbene), a ...
DOI:: 10.1021/acs.jafc.7b04129
: https://doi.org/10.1021/acs.jafc.7b04129

100. Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets

Author:: Fayth L. Miles; Sandi L. Navarro; Yvonne Schwarz; Haiwei Gu; Danijel Djukovic; Timothy W. Randolph; Ali Shojaie; Mario Kratz; Meredith A. J. Hullar; Paul D. Lampe; Marian L. Neuhouser; Daniel Raftery; Johanna W. Lampe
Source:: Food & function 2017 v.8 no.9 pp. 3209-3218
ISSN:: 2042-650X
Subject:: adults; biosynthesis; blood sampling; chronic diseases; creatine; cross-sectional studies; databases; digestive system; epinephrine; excretion; females; fiber content; food records; gas chromatography-mass spectrometry; glycemic index; glyceraldehyde; hippuric acid; intestinal microorganisms; lignans; liquid chromatography; males; melatonin; metabolites; metabolomics; myristic acid; polyphenols; risk reduction; urine
Abstract:: ... Enterolignans, products of gut bacterial metabolism of plant lignans, have been associated with reduced risk of chronic diseases, but their association with other plasma metabolites is unknown. We examined plasma metabolite profiles according to urinary enterolignan excretion in a cross-sectional analysis using data from a randomized crossover, controlled feeding study. Eighty healthy adult males ...
DOI:: 10.1039/c7fo00684e
PubMed:: 28808723
PubMed Central:: PMC5607107
: https://doi.org/10.1039/c7fo00684e

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1. (-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1

2. Absorption, distribution, metabolism, and excretion of [14C]sesamin in rats

3. Anti-biofilm activity against Staphylococcus aureus MRSA and MSSA of neolignans and extract of Piper regnellii

4. Anti-complementary constituents of Anchusa italica

5. Anti-inflammatory neolignans from Epimedium pseudowushanese

6. Antibacterial neolignans from the leaves of Melaleuca bracteata

7. Antioxidant and cytotoxic lignans from the roots of Bupleurum chinense

8. Antiplasmodial Securinega alkaloids from Phyllanthus fraternus: Discovery of natural (+)-allonorsecurinine

9. Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome

10. Arctigenin represses TGF-β-induced epithelial mesenchymal transition in human lung cancer cells

11. Association between Dietary Share of Ultra-Processed Foods and Urinary Concentrations of Phytoestrogens in the US

12. Association between Urinary Phytoestrogens and C-reactive Protein in the Continuous National Health and Nutrition Examination Survey

13. Association of Polyphenol Biomarkers with Cardiovascular Disease and Mortality Risk: A Systematic Review and Meta-Analysis of Observational Studies

14. Asymmetric synthesis of furofurans

15. Bifidobacterium adolescentis INIA P784: The first probiotic bacterium capable of producing enterodiol from lignan extracts

16. Bioactive Asarone-Derived Phenylpropanoids from the Rhizome of Acorus tatarinowii Schott

17. Bioactive Glycosides from the Twigs of Litsea cubeba

18. Bioactive lignans and flavones with in vitro antioxidant and neuroprotective properties from Rubus idaeus rhizome

19. Bioactive phenolics from in vitro cultures of Lactuca aculeata Boiss. et Kotschy

20. Bioactive phytochemicals in barley

21. Biotransformation of lignan glycoside to its aglycone by Woodfordia fruticosa flowers: quantification of compounds using a validated HPTLC method

22. Can sesame consumption improve blood pressure? A systematic review and meta‐analysis of controlled trials

23. Changes in phenolic composition in olive tree parts according to development stage

24. Characterization of Phase I and Phase II Hepatic Metabolism and Reactive Intermediates of Larrea nitida Cav. and Its Lignan Compounds

25. Chemical Composition and Immuno‐Modulatory Effects of Urtica dioica L. (Stinging Nettle) Extracts

26. Chemical Composition and UVA-Protecting Activity of Extracts from Ligustrum vulgare and Olea europaea Leaves

27. Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa

28. Chemical profiling and antioxidant evaluation of Yangxinshi Tablet by HPLC–ESI-Q-TOF-MS/MS combined with DPPH assay

29. Chiral separation and chemical profile of Dengzhan Shengmai by integrating comprehensive with multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

30. Comparative analysis of the in-vitro antioxidant activity and bioactive compounds of flaxseed in China according to variety and geographical origin

31. Composition and Statistical Analysis of Biophenols in Apulian Italian EVOOs

32. Comprehensive profiling and characterization of chemical constituents of rhizome of Anemarrhena asphodeloides Bge.

33. The Contents of Lignans in Sesame Seeds and Commercial Sesame Oils of China

34. Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies

35. Cytotoxic neolignans from the traditional Chinese medicine Daphniphyllum macropodum Miq.

36. Derivatives of the Lignan 7′-Hydroxymatairesinol with Antioxidant Properties and Enhanced Lipophilicity

37. Diarylpropanes and lignans from Horsfieldia tetratepala

38. Dibenzocyclooctadiene lignans from Kadsura heteroclita

39. Diterpenoids and Lignans from Cephalotaxus fortunei

40. Effect of Antibiotics and Diet on Enterolactone Concentration and Metabolome Studied by Targeted and Nontargeted LC–MS Metabolomics

41. Enantiomeric 8-O-4′ type neolignans from red raspberry as potential inhibitors of β-amyloid aggregation

42. Enterolactone alters FAK-Src signaling and suppresses migration and invasion of lung cancer cell lines

43. Evaluation of antioxidant activity, total phenolics, total flavonoids and LC–MS/MS characterisation of phenolic constituents in Stachys lavandulifolia

44. Expression in Pichia pastoris and characterization of two novel dirigent proteins for atropselective formation of gossypol

45. Extraction of Flaxseed Oil: A Comparative Study of Three-Phase Partitioning and Supercritical Carbon Dioxide Using Response Surface Methodology

46. Extraction of bioactive compounds from sesame (Sesamum indicum L.) defatted seeds using water and ethanol under sub-critical conditions

47. Fargesin exerts anti-inflammatory effects in THP-1 monocytes by suppressing PKC-dependent AP-1 and NF-ĸB signaling

48. Flavonol glycosides and lignans from the leaves of Opilia amentacea

49. Flaxseed and multigrain mixtures in the development of functional biscuits

50. Functional characterization of the pinoresinol–lariciresinol reductase-2 gene reveals its roles in yatein biosynthesis and flax defense response

51. Furofuran lignan glucosides from the leaves of Vitex negundo var. cannabifolia

52. Furofuran lignans from the Simpson Desert species Eremophila macdonnellii

53. Gardenifolins A–H, Scalemic Neolignans from Gardenia ternifolia: Chiral Resolution, Configurational Assignment, and Cytotoxic Activities against the HeLa Cancer Cell Line

54. Genetic toxicity of Epimedium koreanum Nakai

55. Genistein and enterolactone in relation to Ki‐67 expression and HER2 status in postmenopausal breast cancer patients

56. High‐throughput ultra high performance liquid chromatography combined with mass spectrometry approach for the rapid analysis and characterization of multiple constituents of the fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms

57. Identification of metabolites in human and rat urine after oral administration of Xiao‐Qing‐Long‐Tang granule using ultra high performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

58. Identification, classification and transcriptional profiles of dirigent domain-containing proteins in sugarcane

59. Identification, in vitro and in vivo Antioxidant Activity, and Gastrointestinal Stability of Lignans from Silver Fir (Abies alba) Wood Extract

60. Impact of extraction techniques on antioxidant capacities and phytochemical composition of polyphenol-rich extracts

61. Impact of lignans on the polyunsaturated fatty acid metabolic processing in a rainbow trout (Oncorhynchus mykiss) cell line

62. In vitro schistosomicidal activity of the lignan (−)-6,6′-dinitrohinokinin (DNHK) loaded into poly(lactic-co-glycolic acid) nanoparticles against Schistosoma mansoni

63. In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans

64. Isolation and Identification of the Novel Tubulin Polymerization Inhibitor Bifidenone

65. Isolation of a new β-carboline alkaloid from aerial parts of Triclisia sacleuxii and its antibacterial and cytotoxicity effects

66. Kudsuphilactone B, a nortriterpenoid isolated from Schisandra chinensis fruit, induces caspase-dependent apoptosis in human ovarian cancer A2780 cells

67. LC-MS profiling highlights hazelnut (Nocciola di Giffoni PGI) shells as a byproduct rich in antioxidant phenolics

68. Larvicidal activity of lignans and alkaloid identified in Zanthoxylum piperitum bark toward insecticide-susceptible and wild Culex pipiens pallens and Aedes aegypti

69. Lignan glycosides from the Rhizomes of Smilax trinervula and their Biological activities

70. Lignans and diterpenes isolated from Tirpitzia ovoidea and their biological activities