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- Srivastava, Kumkum, et al. Show all 8 Authors
- Biochemistry 2017 v.56 no.51 pp. 6691-6699
- DNA damage; Plasmodium falciparum; Protozoa; antigenic variation; antimalarials; chromatin; death; genes; homeostasis; humans; immune evasion; ligands; malaria; parasites; pathogenesis; pyridines; telomeres; toxicity; toxicity testing; transcription (genetics)
- ... The unique occurrence of G-quadruplexes in the AT-rich genome of human malaria parasite Plasmodium falciparum provides hints about their critical roles in parasite survival, pathogenesis, and host immune evasion. An intriguing question is whether these noncanonical structures can serve as molecular targets for small molecule-based interventions against malaria. In this study, we have investigated ...
- Srivastava, Kumkum, et al. Show all 10 Authors
- Phytomedicine 2017 v.30 pp. 1-9
- Flacourtia indica; Plasmodium falciparum; aerial parts; alcohols; antimalarials; antiparasitic properties; binding capacity; body weight; chemotypes; glycosides; heme; in vitro studies; malaria; mechanism of action; mice; oxidative stress; parasitemia; parasites; pathogenesis; polymerization; spectral analysis; Africa
- ... Flacourtia indica is especially popular among the various communities of many African countries where it is being used traditionally for the treatment of malaria. In our previous report, we have identified some phenolic glycosides from the aerial parts of F. indica as promising antiplasmodial agents under in vitro conditions.Antimalarial bioprospection of F. indica derived phenolic glycoside in Sw ...