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You searched for: Subject "median effective concentration" Remove constraint Subject: "median effective concentration" Publication Year 2017 Remove constraint Publication Year: 2017 Subject median effective concentration Remove constraint Subject: median effective concentration Subject Human immunodeficiency virus 1 Remove constraint Subject: Human immunodeficiency virus 1 Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. New phenylpropanoid and 6H-dibenzo[b,d]pyran-6-one derivatives from the stems of Dasymaschalon rostratum

Author:
Yu, Zhang-Xin; Niu, Zhi-Gang; Li, Xiao-Bao; Zheng, Cai-Juan; Song, Xin-Ming; Chen, Guang-Ying; Song, Xiao-Ping; Han, Chang-Ri; Wu, Shu-Xian
Source:
Fitoterapia 2017 v.118 pp. 27-31
ISSN:
0367-326X
Subject:
median effective concentration,   etc   ; Human immunodeficiency virus 1; X-ray diffraction; antiviral properties; cinnamic acid; cyclohexenes; spectroscopy; stems;     Show all 8 Subjects
Abstract:
... Three new phenylpropanoid derivatives, dasymaroacid A (1), dasymaroesters B and C (2 and 3), and one new polyoxygenated 6H-dibenzo[b,d]pyran-6-one derivative dasymarolactone D (4), together with seven known compounds (5–11), were isolated from the stems of Dasymaschalon rostratum Merr. Compounds 1 and 2 are unusual phenylpropanoid derivatives with a polymethyl substituted cyclopentene conjugated d ...
DOI:
10.1016/j.fitote.2017.02.003

2. In vivo electroporation in DNA-VLP prime-boost preferentially enhances HIV-1 envelope-specific IgG2a, neutralizing antibody and CD8 T cell responses

Author:
Huang, Xun; Zhu, Qianqian; Huang, Xiaoxing; Yang, Lifei; Song, Yufeng; Zhu, Ping; Zhou, Paul
Source:
Vaccine 2017 v.35 no.16 pp. 2042-2051
ISSN:
0264-410X
Subject:
median effective concentration,   etc   ; CD8-positive T-lymphocytes; Drosophila; Human immunodeficiency virus 1; electroporation; immune response; immunization; immunoglobulin G; interferon-gamma; interleukin-2; mice; neutralization; neutralizing antibodies; plasmids; recombinant vaccines; tumor necrosis factor-alpha; virus-like particles; viruses;     Show all 18 Subjects
Abstract:
... Although in vivo electroporation (EP) has been utilized to improve immunogenicity in DNA vaccines alone or in prime-boost regimens with both proteins and viral-vectors, no studies on in vivo EP in DNA-VLP prime-boost regimens against HIV-1 have been reported. Previously we developed stably transfected Drosophila S2 clones to produce HIV-1 virus-like particles (VLP) and demonstrated that priming mi ...
DOI:
10.1016/j.vaccine.2017.03.006

3. Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata

Author:
Nothias, Louis-Félix; Boutet-Mercey, Stéphanie; Cachet, Xavier; De La Torre, Erick; Laboureur, Laurent; Gallard, Jean-François; Retailleau, Pascal; Brunelle, Alain; Dorrestein, Pieter C.; Costa, Jean; Bedoya, Luis M.; Roussi, Fanny; Leyssen, Pieter; Alcami, José; Paolini, Julien; Litaudon, Marc; Touboul, David
Source:
Journal of natural products 2017 v.80 no.10 pp. 2620-2629
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Chikungunya virus; Euphorbia; Human immunodeficiency virus 1; X-ray diffraction; antiviral agents; antiviral properties; diterpenoids; esters; plant extracts; secondary metabolites; solvents; supercritical fluid chromatography; tandem mass spectrometry; toxicity; virus replication; viruses;     Show all 17 Subjects
Abstract:
... A supercritical fluid chromatography-based targeted purification procedure using tandem mass spectrometry and molecular networking was developed to analyze, annotate, and isolate secondary metabolites from complex plant extract mixture. This approach was applied for the targeted isolation of new antiviral diterpene esters from Euphorbia semiperfoliata whole plant extract. The analysis of bioactive ...
DOI:
10.1021/acs.jnatprod.7b00113

4. Cycloartane triterpenoid and its glucoside isolated from Cassia occidentalis

Author:
LI, Shi-Fei; LI, Shun-Lin
Source:
Chinese journal of natural medicines 2017 v.15 no.12 pp. 950-954
ISSN:
1875-5364
Subject:
median effective concentration,   etc   ; Human immunodeficiency virus 1; Oriental traditional medicine; Senna occidentalis; antiviral properties; glucosides; mass spectrometry; nuclear magnetic resonance spectroscopy; therapeutics; triterpenoids;     Show all 10 Subjects
Abstract:
... In the present study, one new cycloartane triterpenoid, named cycloccidentalic acid C (1) and its glucoside, cycloccidentaliside VI (2) were isolated from the whole plant of Cassia occidentalis. Their structures were elucidated by a combinational analyses of 1D and 2D NMR data and HRMS. Compound 2 showed modest anti-HIV-1 activity with EC50 value of 1.44 μmol·L⁻¹ and TI (Therapeutic Index) value o ...
DOI:
10.1016/S1875-5364(18)30012-8