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You searched for: Subject "median effective concentration" Remove constraint Subject: "median effective concentration" Publication Year 2017 Remove constraint Publication Year: 2017 Subject median effective concentration Remove constraint Subject: median effective concentration Subject diterpenoids Remove constraint Subject: diterpenoids Subject chromatography Remove constraint Subject: chromatography Subject Chikungunya virus Remove constraint Subject: Chikungunya virus
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1. Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking

Author:
Esposito, Mélissa; Nothias, Louis-Félix; Retailleau, Pascal; Costa, Jean; Roussi, Fanny; Neyts, Johan; Leyssen, Pieter; Touboul, David; Litaudon, Marc; Paolini, Julien
Source:
Journal of natural products 2017 v.80 no.7 pp. 2051-2059
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Chikungunya virus; Euphorbia; active ingredients; aerial parts; chromatography; diterpenoids; esters; nuclear magnetic resonance spectroscopy; spectral analysis;     Show all 10 Subjects
Abstract:
... Six new premyrsinol esters (1–6) and one new myrsinol ester (8) were isolated from an aerial parts extract of Euphorbia pithyusa, together with a known premyrsinol (7) and two known dideoxyphorbol esters (9 and 10), following a bioactivity-guided purification procedure using a chikungunya virus (CHIKV) cell-based assay. The structures of the new diterpene esters (1–6 and 8) were elucidated by MS a ...
DOI:
10.1021/acs.jnatprod.7b00233