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You searched for: Subject "median effective concentration" Remove constraint Subject: "median effective concentration" Publication Year 2017 Remove constraint Publication Year: 2017 Subject median effective concentration Remove constraint Subject: median effective concentration Subject diterpenoids Remove constraint Subject: diterpenoids
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1. Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking

Author:
Esposito, Mélissa; Nothias, Louis-Félix; Retailleau, Pascal; Costa, Jean; Roussi, Fanny; Neyts, Johan; Leyssen, Pieter; Touboul, David; Litaudon, Marc; Paolini, Julien
Source:
Journal of natural products 2017 v.80 no.7 pp. 2051-2059
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Chikungunya virus; Euphorbia; active ingredients; aerial parts; chromatography; diterpenoids; esters; nuclear magnetic resonance spectroscopy; spectral analysis;     Show all 10 Subjects
Abstract:
... Six new premyrsinol esters (1–6) and one new myrsinol ester (8) were isolated from an aerial parts extract of Euphorbia pithyusa, together with a known premyrsinol (7) and two known dideoxyphorbol esters (9 and 10), following a bioactivity-guided purification procedure using a chikungunya virus (CHIKV) cell-based assay. The structures of the new diterpene esters (1–6 and 8) were elucidated by MS a ...
DOI:
10.1021/acs.jnatprod.7b00233

2. ent-Rosane diterpenoids from Euphorbia milii showing an Epstein–Barr virus lytic replication assay

Author:
Liu, Shao-Nan; Hu, Jiayuan; Tan, Shen H.; Wang, Qian; Xu, Jun; Wang, Yan; Yuan, Yan; Gu, Qiong
Source:
RSC advances 2017 v.7 no.74 pp. 46938-46947
ISSN:
2046-2069
Subject:
median effective concentration,   etc   ; DNA; Euphorbia milii; Human gammaherpesvirus 4; acetone; bioassays; chemical constituents of plants; circular dichroism spectroscopy; diterpenoids; fractionation; nuclear magnetic resonance spectroscopy; spectral analysis;     Show all 12 Subjects
Abstract:
... The phytochemical investigation on the acetone extract of Euphorbia milii afforded thirteen new ent-rosane diterpenoids (1–13) through bioassay guided fractionation for evaluating its effect on Epstein–Barr virus (EBV) DNA lytic replication. Structures were determined by comprehensive spectroscopic analyses including 1D & 2D NMR techniques, chemical methods, and experimental and calculated electro ...
DOI:
10.1039/c7ra08877a

3. Antifouling activity against bryozoan and barnacle by cembrane diterpenes from the soft coral Sinularia flexibilis

Author:
Wang, Jia; Su, Pei; Gu, Qiong; Li, Wei Dong; Guo, Jia Lin; Qiao, Wei; Feng, Dan Qing; Tang, Sheng An
Source:
International biodeterioration & biodegradation 2017 v.120 pp. 97-103
ISSN:
0964-8305
Subject:
median effective concentration,   etc   ; Bryozoa; Fistulobalanus albicostatus; Neritina; Sinularia; antifouling activities; chemical defenses; corals; diterpenoids; fouling; high performance liquid chromatography; larvae; lethal concentration 50; toxicity;     Show all 14 Subjects
Abstract:
... In the present study, seven cembrane diterpenes were isolated from the soft coral Sinularia flexibilis by Toyopearl HW-40 column chromatography and High Performance Liquid Chromatography (HPLC). The diterpenes were identified as epoxycembrane A (1), sinularin (2), sinulariolide (3), (1R,13S,12S,9S,8R,5S,4R)-9-acetoxy-5,8:12,13-diepoxycembr-15(17)-en-16,4-olide (4), 11-dehydrosinulariolide (5), (−) ...
DOI:
10.1016/j.ibiod.2017.02.013

4. Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata

Author:
Nothias, Louis-Félix; Boutet-Mercey, Stéphanie; Cachet, Xavier; De La Torre, Erick; Laboureur, Laurent; Gallard, Jean-François; Retailleau, Pascal; Brunelle, Alain; Dorrestein, Pieter C.; Costa, Jean; Bedoya, Luis M.; Roussi, Fanny; Leyssen, Pieter; Alcami, José; Paolini, Julien; Litaudon, Marc; Touboul, David
Source:
Journal of natural products 2017 v.80 no.10 pp. 2620-2629
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Chikungunya virus; Euphorbia; Human immunodeficiency virus 1; X-ray diffraction; antiviral agents; antiviral properties; diterpenoids; esters; plant extracts; secondary metabolites; solvents; supercritical fluid chromatography; tandem mass spectrometry; toxicity; virus replication; viruses;     Show all 17 Subjects
Abstract:
... A supercritical fluid chromatography-based targeted purification procedure using tandem mass spectrometry and molecular networking was developed to analyze, annotate, and isolate secondary metabolites from complex plant extract mixture. This approach was applied for the targeted isolation of new antiviral diterpene esters from Euphorbia semiperfoliata whole plant extract. The analysis of bioactive ...
DOI:
10.1021/acs.jnatprod.7b00113

5. Chemical profile and defensive function of the latex of Euphorbia peplus

Author:
Hua, Juan; Liu, Yan; Xiao, Chao-Jiang; Jing, Shu-Xi; Luo, Shi-Hong; Li, Sheng-Hong
Source:
Phytochemistry 2017 v.136 pp. 56-64
ISSN:
0031-9422
Subject:
median effective concentration,   etc   ; Colletotrichum; Euphorbia peplus; Fusarium oxysporum f. sp. niveum; Helicoverpa armigera; Litchi; Thanatephorus cucumeris; alcohols; antifeeding activity; antifungal properties; diterpenoids; high performance liquid chromatography; latex; metabolites; neem oil; plant pathogenic fungi; triterpenoids;     Show all 17 Subjects
Abstract:
... Plant latex is an endogenous fluid secreted from highly specialized laticifer cells and has been suggested to act as a plant defense system. The chemical profile of the latex of Euphorbia peplus was investigated. A total of 13 terpenoids including two previously unknown diterpenoids, (2S*,3S*,4R*,5R*,6R*,8R*,l1R*,13S*,14S*,15R*, 16R*)-5,8,15-triacetoxy-3-benzoyloxy-11,16-dihydroxy-9-oxopepluane an ...
DOI:
10.1016/j.phytochem.2016.12.021

6. New Nematotoxic Indoloditerpenoid Produced by za-130

Author:
Liu, Ting; Meyer, Susan; Chitwood, David; Chauhan, Kamlesh; Dong, Dan; Zhang, TaoTao; Li, Jun; Liu, Wei-cheng
Source:
Journal of agricultural and food chemistry 2017 v.65 no.15 pp. 3127-3132
ISSN:
0021-8561
Subject:
median effective concentration,   etc   ; Gymnoascus; Meloidogyne incognita; Solanum lycopersicum; acetates; adverse effects; chemical structure; diterpenoids; eggs; juveniles; metabolites; nematicidal properties; nematode control; nematotoxins; paralysis; plant diseases and disorders; rhizosphere; root galls; root-knot nematodes; soil fungi; tomatoes; viability;     Show all 22 Subjects
Abstract:
... Chemical investigation of the fungal strain Gymnoascus reessii za-130, which was previously isolated from the rhizosphere of tomato plants infected by the root-knot nematode Meloidogyne incognita, led to the isolation and identification of a new indoloditerpenoid metabolite designated gymnoascole acetate. Its structure was established by spectroscopic methods including 1D- and 2D-NMR and MS analys ...
Handle:
10113/6472181
DOI:
10.1021/acs.jafc.6b04353