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1. Effect of an Imposed Contact on Secondary Structure in the Denatured State of Yeast Iso-1-cytochrome c

Author:
Dar, Tanveer A.,   et al.   ; Danielson, Travis A.; Stine, Jessica M.; Briknarova, Klara; Bowler, Bruce E.;     Show all 5 Authors
Source:
Biochemistry 2017 v.56 no.51 pp. 6662-6676
ISSN:
1520-4995
Subject:
carbon; cytochrome c; guanidines; models; mutation; nitrogen; nuclear magnetic resonance spectroscopy; pH; protein secondary structure; stable isotopes; yeasts
Abstract:
... There is considerable evidence that long-range interactions stabilize residual protein structure under denaturing conditions. However, evaluation of the effect of a specific contact on structure in the denatured state has been difficult. Iso-1-cytochrome c variants with a Lys54 → His mutation form a particularly stable His–heme loop in the denatured state, suggestive of loop-induced residual struc ...
DOI:
10.1021/acs.biochem.7b01002
PubMed:
29148740
PubMed Central:
PMC5751441