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- Mong, Surin
K.; Cochran, Frank V.; Yu, Hongtao; Graziano, Zachary; Lin, Yu-Shan; Cochran, Jennifer R.; Pentelute, Bradley L.
- Biochemistry 2017 v.56 no.43 pp. 5720-5725
- trypsin inhibitors, etc ; Ecballium elaterium; Gibbs free energy; beta-alanine; molecular dynamics; nuclear magnetic resonance spectroscopy; optical isomerism; proteolysis; scaffolding proteins; Show all 9 Subjects
- ... Homochirality is a general feature of biological macromolecules, and Nature includes few examples of heterochiral proteins. Herein, we report on the design, chemical synthesis, and structural characterization of heterochiral proteins possessing loops of amino acids of chirality opposite to that of the rest of a protein scaffold. Using the protein Ecballium elaterium trypsin inhibitor II, we discov ...
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