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1. The integrity of PRRSV nucleocapsid protein is necessary for up-regulation of optimal interleukin-10 through NF-κB and p38 MAPK pathways in porcine alveolar macrophages

Author:
Wu, Jiaqiang,   et al.   ; Yu, Jiang; Liu, Yanyan; Zhang, Yuyu; Zhu, Xiwang; Ren, Sufang; Guo, Lihui; Liu, Xing; Sun, Wenbo; Chen, Zhi; Cong, Xiaoyan; Chen, Lei; Shi, Jianli; Du, Yijun; Li, Jun; Wang, Jinbao;     Show all 16 Authors
Source:
Microbial pathogenesis 2017 v.109 pp. 319-324
ISSN:
0882-4010
Subject:
Porcine reproductive and respiratory syndrome virus; dose response; financial economics; immunosuppression; interleukin-10; macrophages; mitogen-activated protein kinase; nucleocapsid; nucleocapsid proteins; porcine reproductive and respiratory syndrome; signal transduction; swine; transcription factor NF-kappa B; viruses
Abstract:
... Porcine reproductive and respiratory syndrome (PRRS), a highly contagious disease, has been constantly causing huge economic losses all over the world. PRRS virus (PRRSV) infection results in immunosuppression and IL-10 up-regulation. The relationship between them is still in dispute. Previous studies demonstrated the protein of PRRSV nucleocapsid (N) protein is able to up-regulate IL-10, yet the ...
DOI:
10.1016/j.micpath.2017.04.036