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- Jong, Yuh-Jyh, et al. Show all 5 Authors
- Phytomedicine 2017 v.34 pp. 97-105
- B-lymphocytes; Western blotting; animal models; apoptosis; body weight; brain; bromides; caspase-3; cell viability; cytochrome c; doxycycline; genes; lactate dehydrogenase; membrane potential; mice; mitochondrial membrane; motor neurons; muscle strength; muscle tissues; muscles; muscular atrophy; neurites; neurodegenerative diseases; neurotoxicity; protein kinases; spinal cord
- ... Deficiency of survival motor neuron (SMN) protein, which is encoded by the SMN1 and SMN2 genes, induces widespread splicing defects mainly in spinal motor neurons, and leads to spinal muscular atrophy (SMA). Currently, there is no effective treatment for SMA. Liuwei dihuang (LWDH), a traditional Chinese herbal formula, possesses multiple therapeutic benefits against various diseases via modulation ...