Jump to Main Content
- Wang, A. Hongjun, et al. Show all 7 Authors
- Molecular cell 2017 v.68 no.2 pp. 398-413.e6
- acetylation; embryonic stem cells; genomics; histones; messenger RNA; methylation; methyltransferases; nucleosomes; transcription (genetics)
- ... Spt6 coordinates nucleosome dis- and re-assembly, transcriptional elongation, and mRNA processing. Here, we report that depleting Spt6 in embryonic stem cells (ESCs) reduced expression of pluripotency factors, increased expression of cell-lineage-affiliated developmental regulators, and induced cell morphological and biochemical changes indicative of ESC differentiation. Selective downregulation o ...
- PubMed Central: