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1. Photoelectrochemical enzymatic biosensors

Author:
Chen, Hong-Yuan,   et al.   ; Zhao, Wei-Wei; Xu, Jing-Juan;     Show all 3 Authors
Source:
Biosensors & bioelectronics 2017 v.92 pp. 294-304
ISSN:
0956-5663
Subject:
attitudes and opinions; biomedical research; biosensors; disease diagnosis; enzymes; surveys
Abstract:
... Enzymatic biosensors have been valuable bioanalytical devices for analysis of diverse targets in disease diagnosis, biological and biomedical research, etc. Photoelectrochemical (PEC) bioanalysis is a recently emerged method that promptly becoming a subject of new research interests due to its attractive potential for future bioanalysis with high sensitivity and specificity. PEC enzymatic biosenso ...
DOI:
10.1016/j.bios.2016.11.009

2. ATP-Activatable Photosensitizer Enables Dual Fluorescence Imaging and Targeted Photodynamic Therapy of Tumor

Author:
Chen, Hong-Yuan,   et al.   ; Shen, Yizhong; Tian, Qian; Sun, Yidan; Xu, Jing-Juan; Ye, Deju;     Show all 6 Authors
Source:
Analytical chemistry 2017 v.89 no.24 pp. 13610-13617
ISSN:
1520-6882
Subject:
adenosine triphosphate; adverse effects; color; dissociation; emissions; endocytosis; fluorescence; image analysis; mice; micelles; monitoring; nanoparticles; neoplasm cells; neoplasms; oligonucleotides; photochemotherapy; photosensitizing agents
Abstract:
... Targeted delivery of intracellular stimuli-activatable photosensitizers (PSs) into tumor cells to achieve selective imaging and on-demand photodynamic therapy (PDT) of tumors has provided a vital opportunity for precise cancer diagnosis and therapy. In this paper, we report a tumor targeting and adenosine triphosphate (ATP)-activatable nanophotosensitizer Apt-HyNP/BHQ₂ by modifying hybrid micellar ...
DOI:
10.1021/acs.analchem.7b04197

3. Localized Electrochemiluminescence from Nanoneedle Electrodes for Very-High-Density Electrochemical Sensing

Author:
Chen, Hong-Yuan,   et al.   ; Zhang, Jingjing; Zhou, Junyu; Tian, Chunxiu; Yang, Shan; Jiang, Dechen; Zhang, Xi-Xiang;     Show all 7 Authors
Source:
Analytical chemistry 2017 v.89 no.21 pp. 11399-11404
ISSN:
1520-6882
Subject:
electrochemiluminescence; electrochemistry; electrodes; glucose; glucose oxidase; hydrogen peroxide; light intensity; mass transfer
Abstract:
... In this paper, localized electrochemiluminescence (ECL) was visualized from nanoneedle electrodes that achieved very-high-density electrochemical sensing. The localized luminescence at the nanometer-sized tip observed was ascribed to enhanced mass transfer of the luminescence probe at the tip than on the planar surface surrounding the tip, which provided higher luminescence at the tip. The size of ...
DOI:
10.1021/acs.analchem.7b02363

4. Nanopore-Based Electrochemiluminescence for Detection of MicroRNAs via Duplex-Specific Nuclease-Assisted Target Recycling

Author:
Chen, Hong-Yuan,   et al.   ; Huo, Xiao-Lei; Yang, Hui; Zhao, Wei; Xu, Jing-Juan;     Show all 5 Authors
Source:
ACS applied materials & interfaces 2017 v.9 no.38 pp. 33360-33367
ISSN:
1944-8252
Subject:
DNA; aluminum oxide; detection limit; electrochemiluminescence; electrodes; electrostatic interactions; gold; microRNA; nanogold; nanopores; synergism
Abstract:
... In this study, we proposed a nanopore-based electrochemiluminescence (ECL) sensor combined with duplex-specific nuclease (DSN)-assisted target recycling amplification to detect microRNAs. Because of the synergetic effect of electrostatic repulsion and volume exclusion of gold nanoparticle-labeled DNA capture (DNA-Au NPs) to the negatively charged luminol anion probe, the DNA-Au NP-modified anodize ...
DOI:
10.1021/acsami.7b11524

5. Quantum-dots-based photoelectrochemical bioanalysis highlighted with recent examples

Author:
Chen, Hong-Yuan,   et al.   ; Zhang, Nan; Zhang, Ling; Ruan, Yi-Fan; Zhao, Wei-Wei; Xu, Jing-Juan;     Show all 6 Authors
Source:
Biosensors & bioelectronics 2017 v.94 pp. 207-218
ISSN:
0956-5663
Subject:
analytical methods; electrochemistry; nanocrystals; quantum dots; research
Abstract:
... Photoelectrochemical (PEC) bioanalysis is a newly developed methodology that provides an exquisite route for innovative biomolecular detection. Quantum dots (QDs) are semiconductor nanocrystals with unique photophysical properties that have attracted tremendous attentions among the analytical community. QDs-based PEC bioanalysis comprises an important research hotspot in the field of PEC bioanalys ...
DOI:
10.1016/j.bios.2017.03.011

6. Collision and Oxidation of Single LiCoO2 Nanoparticles Studied by Correlated Optical Imaging and Electrochemical Recording

Author:
Chen, Hong-Yuan,   et al.   ; Sun, Linlin; Jiang, Dan; Li, Meng; Liu, Tao; Yuan, Liang; Wang, Wei;     Show all 7 Authors
Source:
Analytical chemistry 2017 v.89 no.11 pp. 6050-6055
ISSN:
1520-6882
Subject:
anodes; batteries; cathodes; electrochemistry; electron transfer; image analysis; nanoparticles; oxidation; scanning electron microscopy; structure-activity relationships; surface plasmon resonance
Abstract:
... Electrochemists have witnessed the rapid development of single nanoparticle collision (SNC) in the past decade as a powerful technology to study the electrochemical activity of single nanoparticles (NPs). One of the ultimate goals of SNC is to build the structure–activity relationship in a bottom-up way, which requires the correlation between the electrochemical activity and the morphology/structu ...
DOI:
10.1021/acs.analchem.7b00649

7. Fast Electrochemical and Plasmonic Detection Reveals Multitime Scale Conformational Gating of Electron Transfer in Cytochrome c

Author:
Chen, Hong-Yuan,   et al.   ; Wang, Yan; Wang, Hui; Chen, Yuheng; Wang, Yixian; Shan, Xiaonan; Tao, Nongjian;     Show all 7 Authors
Source:
Journal of the American Chemical Society 2017 v.139 no.21 pp. 7244-7249
ISSN:
1520-5126
Subject:
cytochrome c; electrochemistry; electron transfer; monitoring
Abstract:
... Conformational fluctuations play a central role in the electron transfer reactions of molecules. Because the fluctuations can be extremely fast in kinetics and small in amplitude, a technique with fast temporal resolution and high conformational sensitivity is needed to follow the transient electron transfer processes. Here we report on an electrochemically controlled plasmonic detection technique ...
DOI:
10.1021/jacs.7b00839

8. Self-Assembled DNA Tetrahedral Scaffolds for the Construction of Electrochemiluminescence Biosensor with Programmable DNA Cyclic Amplification

Author:
Chen, Hong-Yuan,   et al.   ; Feng, Qiu-Mei; Guo, Yue-Hua; Xu, Jing-Juan;     Show all 4 Authors
Source:
ACS Applied Materials & Interfaces 2017 v.9 no.20 pp. 17637-17644
ISSN:
1944-8252
Subject:
DNA; biosensors; electrochemiluminescence; electrodes; glucose; glucose oxidase; hydrogen peroxide; nanoparticles; nucleotide sequences; silica
Abstract:
... A novel DNA tetrahedron-structured electrochemiluminescence (ECL) platform for bioanalysis with programmable DNA cyclic amplification was developed. In this work, glucose oxidase (GOD) was labeled to a DNA sequence (S) as functional conjugation (GOD-S), which could hybridize with other DNA sequences (L and P) to form GOD-S:L:P probe. In the presence of target DNA and a help DNA (A), the programmab ...
DOI:
10.1021/acsami.7b04553

9. A multifunctional silver nanocomposite for the apoptosis of cancer cells and intracellular imaging

Author:
Chen, Hong-Yuan,   et al.   ; Zhang, Ting-Ting; Yang, Fan; Li, Xiang-ling; Zhao, Wei; Xu, Jing-Juan;     Show all 6 Authors
Source:
Chemical communications 2017 v.53 no.41 pp. 5614-5617
ISSN:
1364-548X
Subject:
apoptosis; image analysis; nanocomposites; nanosilver; neoplasm cells; neoplasms; silver; therapeutics
Abstract:
... A multifunctional Ag NP based nanocomposite was fabricated which realized accurate targeting of specific cancer cells and completely initiative therapy without any photoexcitation. ...
DOI:
10.1039/c7cc02834b

10. DNA sequence functionalized with heterogeneous core–satellite nanoassembly for novel energy-transfer-based photoelectrochemical bioanalysis

Author:
Chen, Hong-Yuan,   et al.   ; Zhu, Yuan-Cheng; Xu, Fei; Zhang, Nan; Zhao, Wei-Wei; Xu, Jing-Juan;     Show all 6 Authors
Source:
Biosensors & bioelectronics 2017 v.91 pp. 293-298
ISSN:
0956-5663
Subject:
DNA; antibodies; antigens; biosensors; detection limit; electrodes; energy transfer; glass; immunoassays; indium tin oxide; nanogold; nanosilver; nucleotide sequences; oligonucleotides
Abstract:
... This work reports the use of compositionally heterogeneous asymmetric Ag@Au core–satellite nanoassembly functionalized with DNA sequence as unique signaling nanoprobes for the realization of new energy-transfer-based photoelectrochemical (PEC) immunoassay of prostate- specific antigen (PSA). Specifically, the Ag@Au asymmetric core–satellite nanoassemblies (Ag@Au ACS) were fabricated on a two-dimen ...
DOI:
10.1016/j.bios.2016.12.045

11. Polymer Dots for Photoelectrochemical Bioanalysis

Author:
Chen, Hong-Yuan,   et al.   ; Li, Yu; Zhang, Nan; Zhao, Wei-Wei; Jiang, De-Chen; Xu, Jing-Juan;     Show all 6 Authors
Source:
Analytical chemistry 2017 v.89 no.9 pp. 4945-4950
ISSN:
1520-6882
Subject:
cysteine; glass electrodes; glutathione; indium tin oxide; models; polymers; quantum dots
Abstract:
... Different from the most extensively used inorganic quantum dots (Qdots) for the current state-of-the-art photoelectrochemical (PEC) bioanalysis, this work reports the first demonstration of polymer dots (Pdots) for novel PEC bioanalysis. The semiconducting Pdots were prepared via the reprecipitation method and then immobilized onto the transparent indium tin oxide glass electrode for PEC biodetect ...
DOI:
10.1021/acs.analchem.7b00162

12. Single-molecule imaging of telomerase activity via linear plasmon rulers

Author:
Chen, Hong-Yuan,   et al.   ; Qian, Guang-Sheng; Zhang, Ting-Ting; Zhao, Wei; Xu, Jing-Juan;     Show all 5 Authors
Source:
Chemical communications 2017 v.53 no.34 pp. 4710-4713
ISSN:
1364-548X
Subject:
chemical reactions; enzyme activity; image analysis; monitoring; nanoparticles; silver; telomerase
Abstract:
... Plasmon rulers (PRs) exploit the potential of plasmon coupling between individual pairs of noble metal nanoparticles in biological processes, especially single-molecule detection. Herein, for the first time, we report a strategy based on Ag PRs for in situ monitoring of the extension process of telomerase primer (TSP) activated by a single telomerase. ...
DOI:
10.1039/c7cc00626h

13. DNA tetrahedral scaffolds-based platform for the construction of electrochemiluminescence biosensor

Author:
Chen, Hong-Yuan,   et al.   ; Feng, Qiu-Mei; Zhou, Zhen; Li, Mei-Xing; Zhao, Wei; Xu, Jing-Juan;     Show all 6 Authors
Source:
Biosensors & bioelectronics 2017 v.90 pp. 251-257
ISSN:
0956-5663
Subject:
DNA; biosensors; electrochemiluminescence; electrodes; energy transfer; nanogold; nanoparticles; neoplasm cells; neoplasms; quantum dots; surface plasmon resonance; telomerase
Abstract:
... Proximal metallic nanoparticles (NPs) could quench the electrochemiluminescence (ECL) emission of semiconductor quantum dots (QDs) due to Förster energy transfer (FRET), but at a certain distance, the coupling of light-emission with surface plasmon resonance (SPR) result in enhanced ECL. Thus, the modification strategies and distances control between QDs and metallic NPs are critical for the ECL i ...
DOI:
10.1016/j.bios.2016.11.060

14. Reliable Förster Resonance Energy Transfer Probe Based on Structure-Switching DNA for Ratiometric Sensing of Telomerase in Living Cells

Author:
Chen, Hong-Yuan,   et al.   ; Yang, Xue-Jiao; Zhang, Kai; Zhang, Ting-Ting; Xu, Jing-Juan;     Show all 5 Authors
Source:
Analytical chemistry 2017 v.89 no.7 pp. 4216-4222
ISSN:
1520-6882
Subject:
DNA; deoxyribonuclease I; drugs; energy transfer; fluorescence; monitoring; nanogold; neoplasm cells; neoplasms; telomerase; therapeutics
Abstract:
... In situ detection and monitoring of telomerase is of great importance as it is a relatively specific cancer target. However, the complexity of the biological system makes it difficult for the nanoprobe to keep absolutely stable and have a low background in living cells. This study designs a probe termed Förster resonance energy transfer (FRET) nanoflare to achieve ratiometric fluorescent detectio ...
DOI:
10.1021/acs.analchem.7b00267

15. A colorimetric/fluorescent dual-mode sensor for ultra-sensitive detection of Hg2+

Author:
Chen, Hong-Yuan,   et al.   ; Yu, Tao; Zhang, Ting-Ting; Zhao, Wei; Xu, Jing-Juan;     Show all 5 Authors
Source:
Talanta 2017 v.165 pp. 570-576
ISSN:
0039-9140
Subject:
aqueous solutions; color; colorimetry; detection limit; fluorescence; industrial effluents; lakes; mercury; metal ions; nanogold; polymers; single-stranded DNA
Abstract:
... A highly sensitive colorimetric/fluorescent dual-mode sensor based on hybridization chain reaction (HCR) combining multifunctional Au NPs is presented for the detection of Hg2+ in aqueous solution. In Hg2+ absent solution, the surface of Au NPs was covered by hairpin auxiliary DNAs and a single strand DNA (ssDNA), which prevented Au NPs from salt-induced aggregation. At the same time, the fluoresc ...
DOI:
10.1016/j.talanta.2017.01.026

16. Attomole Antigen Detection Using Self-Electrochemiluminous Graphene Oxide-Capped Au@L012 Nanocomposite

Author:
Chen, Hong-Yuan,   et al.   ; Cui, Chen; Chen, Ying; Jiang, Dechen; Zhu, Jun-Jie;     Show all 5 Authors
Source:
Analytical chemistry 2017 v.89 no.4 pp. 2418-2423
ISSN:
1520-6882
Subject:
antibodies; antigen detection; electrodes; electrostatic interactions; gold; graphene; graphene oxide; immunoassays; light intensity; nanocomposites; nanogold; nanoparticles; surface antigens
Abstract:
... In this work, a self-electrochemiluminous graphene oxide-capped Au@L012 nanocomposite was prepared as the label at carcinoembryonic (CEA) antibody to detect attomole CEA antigen. To maximize the luminescence intensity, L012 molecules (luminol analogue) were linked with poly(diallyldimethylammonium chloride) (PDDA) to form positive charged PDDA&L012 pairs, which were modified on negative charged Au ...
DOI:
10.1021/acs.analchem.6b04305

17. C3N4 Nanosheet Modified Microwell Array with Enhanced Electrochemiluminescence for Total Analysis of Cholesterol at Single Cells

Author:
Chen, Hong-Yuan,   et al.   ; Xu, Jingjing; Jiang, Depeng; Qin, Yanling; Xia, Juan; Jiang, Dechen;     Show all 6 Authors
Source:
Analytical chemistry 2017 v.89 no.4 pp. 2216-2220
ISSN:
1520-6882
Subject:
carbon nitride; cholesterol; cultured cells; detection limit; electrochemiluminescence; hydrogen peroxide; light intensity; nanosheets; octoxynol; sterol esterase
Abstract:
... Here, a g-C₃N₄ nanosheet modified microwell array providing enhanced electrochemiluminescence (ECL) and better visible sensitivity was prepared to simultaneously analyze total (membrane and intracellular) cholesterol at single cells. The detection limit for ECL visualization of hydrogen peroxide at microwell array was improved to be 500 nM that guaranteed the detection of low concentration cholest ...
DOI:
10.1021/acs.analchem.6b04635

18. Dual-Functional Carbon Dots Pattern on Paper Chips for Fe3+ and Ferritin Analysis in Whole Blood

Author:
Chen, Hong-Yuan,   et al.   ; Hu, Shan-Wen; Qiao, Shu; Xu, Bi-Yi; Peng, Xiang; Xu, Jing-Juan;     Show all 6 Authors
Source:
Analytical chemistry 2017 v.89 no.3 pp. 2131-2137
ISSN:
1520-6882
Subject:
blood cells; blood coagulation; blood serum; carbon; colorimetry; enzyme-linked immunosorbent assay; ferritin; fluorescence; hematologic tests; iron; nanogold; paper
Abstract:
... Though microfluidic paper analytical devices (μPADs) have attracted paramounting attentions in recent years as promising devices for low cost point-of-care tests, their real applications for blood analysis are still challenged by integrating sample preparation with different detection modes on a same μPAD. Herein, we developed a novel μPAD, which well coupled automatic serum extraction with reliab ...
DOI:
10.1021/acs.analchem.6b04891

19. Insight into the Unique Fluorescence Quenching Property of Metal-Organic Frameworks upon DNA Binding

Author:
Chen, Hong-Yuan,   et al.   ; Wang, Huai-Song; Liu, Hai-Ling; Wang, Kang; Ding, Ya; Xu, Jing-Juan; Xia, Xing-Hua;     Show all 7 Authors
Source:
Analytical chemistry 2017 v.89 no.21 pp. 11366-11371
ISSN:
1520-6882
Subject:
DNA; biosensors; coordination polymers; fluorescence; nanoparticles; nanosheets
Abstract:
... Metal-organic frameworks (MOFs) have been successfully used as efficient quenchers for fluorescent DNA detection. However, the surface charge property of MOFs can inevitably affect their fluorescence quenching behavior. Herein, nanoscale MOFs (NMOFs), including MOF nanosheets and nanoparticles, have been employed to investigate the relationship between the fluorescence quenching and surface proper ...
DOI:
10.1021/acs.analchem.7b02256

20. Ultrasensitive MicroRNA Assay via Surface Plasmon Resonance Responses of Au@Ag Nanorods Etching

Author:
Chen, Hong-Yuan,   et al.   ; Gu, Yu; Song, Juan; Li, Mei-Xing; Zhang, Ting-Ting; Zhao, Wei; Xu, Jing-Juan; Liu, Maili;     Show all 8 Authors
Source:
Analytical chemistry 2017 v.89 no.19 pp. 10585-10591
ISSN:
1520-6882
Subject:
DNA; absorption; bioassays; blood serum; color; detection limit; gold; hybridization chain reaction; microRNA; microscopy; nanorods; oligonucleotides; silver; surface plasmon resonance
Abstract:
... Quantification of trace serum circulate microRNAs is extremely important in clinical diagnosis but remains a great challenge. Herein we developed an ultrasensitive platform for microRNA 141 (miR-141) detection based on a silver coated gold nanorods (Au@Ag NRs) etching process accompanied by surface plasmon resonance (SPR) shift. Both SPR absorption and scattering responses were monitored. Combined ...
DOI:
10.1021/acs.analchem.7b02920