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1. Nanofluidic Devices with 8 Pores in Series for Real-Time, Resistive-Pulse Analysis of Hepatitis B Virus Capsid Assembly

Author:
Kondylis, Panagiotis; Zhou, Jinsheng; Harms, Zachary D.; Kneller, Andrew R.; Lee, Lye Siang; Zlotnick, Adam; Jacobson, Stephen C.
Source:
Analytical chemistry 2017 v.89 no.9 pp. 4855-4862
ISSN:
1520-6882
Subject:
Hepatitis B virus,   etc   ; capsid; statistical analysis; uncertainty;     Show all 4 Subjects
Abstract:
... To improve the precision of resistive-pulse measurements, we have used a focused ion beam instrument to mill nanofluidic devices with 2, 4, and 8 pores in series and compared their performance. The in-plane design facilitates the fabrication of multiple pores in series which, in turn, permits averaging of the series of pulses generated from each translocation event. The standard deviations (σ) of ...
DOI:
10.1021/acs.analchem.6b04491
PubMed:
28322548
PubMed Central:
PMC5549943

2. Vaccination against hepatitis B virus among people who inject drugs – A 20year experience from a Swedish needle exchange program

Author:
Alanko Blomé, M.; Björkman, P.; Flamholc, L.; Jacobsson, H.; Widell, A.
Source:
Vaccine 2017 v.35 no.1 pp. 84-90
ISSN:
0264-410X
Subject:
Hepatitis B virus,   etc   ; people; risk; vaccination; vaccines;     Show all 5 Subjects
Abstract:
... People who inject drugs (PWID) are at particular risk of hepatitis B virus (HBV) acquisition, but often have poor access or adherence to HBV vaccination. Vaccination against HBV has been offered at a major Swedish needle exchange program (NEP) since 1994. The aim of this study was to evaluate vaccine completion and response rates, and the effect of sequential booster doses to non-responders to the ...
DOI:
10.1016/j.vaccine.2016.11.041

3. Linear Ru(bpy)32+–Polymer as a Universal Probe for Sensitive Detection of Biomarkers with Controllable Electrochemiluminescence Signal-Amplifying Ratio

Author:
Liao, Yuhui; Zhou, Xiaoming; Fu, Yu; Xing, Da
Source:
Analytical chemistry 2017 v.89 no.23 pp. 13016-13023
ISSN:
1520-6882
Subject:
Hepatitis B virus,   etc   ; antigens; biomarkers; electrochemiluminescence; immunoassays; polymers; thrombin;     Show all 7 Subjects
Abstract:
... Electrochemiluminescence (ECL) has been engineered to perform various tasks in the area of immunoassays and molecular diagnosis. However, there is still substantial potential for developments of ECL assay with high efficiency to achieve trace analysis. Herein, we demonstrate a polymer-amplified ECL assay via construction of linear Ru(bpy)₃²⁺–polymer. This new polymer material compensates for the r ...
DOI:
10.1021/acs.analchem.7b04142

4. A new class of ribozyme from hepatitis B virus

Author:
Lim, Chun Shen; Brown, Christopher
Source:
The FEBS journal 2017 v.284 no.8 pp. 1182-1183
ISSN:
1742-464X
Subject:
Hepatitis B virus,   etc   ; in vitro studies; messenger RNA; ribozymes;     Show all 4 Subjects
Abstract:
... In this issue, Chakraborty and Ghosh present initial in vitro data indicating a 53‐base part of the hepatitis B virus (HBV) epsilon region is a ribozyme with unusual properties. Self‐cleavage first occurred at the HBV non‐canonical polyadenylation signal UAUAAA and the “centre bulge” of the epsilon region, releasing a ribozyme. The released ribozyme then acted as a new class of trans‐cleaving ribo ...
DOI:
10.1111/febs.14062

5. Elevated production of IL-36α in chronic hepatitis B virus-infected patients correlates with viral load

Author:
Gong, Yi; Tingxi, Zhan; Qing, Li; Guozhen, Zhang; Bing, Tan; Xiaoliang, Yang; Yan, Wu; Wenjuan, Jue; Yan, Xing; Hui, Liu; Xue, Hu; Zebo, Yu
Source:
Microbial pathogenesis 2017 v.113 pp. 412-415
ISSN:
0882-4010
Subject:
Hepatitis B virus,   etc   ; chronic hepatitis B; cytokines; enzyme-linked immunosorbent assay; immunity; pathogenesis; patients; viral load;     Show all 8 Subjects
Abstract:
... Chronic hepatitis B (CHB) infection is a typical inflammatory disease characterized by a dysregulated expression of cytokines, which contributes to the pathogenesis of chronic Hepatitis B virus (HBV) infection. IL-36 cytokines (IL-36α, IL-36β, IL-36γ and IL-36Ra) are important players in infection and immunity. However, their roles in the pathogenesis of chronic HBV infection remain unknown. Here ...
DOI:
10.1016/j.micpath.2017.11.023

6. Hepatitis B Virus Capsid Completion Occurs through Error Correction

Author:
Lutomski, Corinne A.; Lyktey, Nicholas A.; Zhao, Zhongchao; Pierson, Elizabeth E.; Zlotnick, Adam; Jarrold, Martin F.
Source:
Journal of the American Chemical Society 2017 v.139 no.46 pp. 16932-16938
ISSN:
1520-5126
Subject:
Hepatitis B virus,   etc   ; capsid; coat proteins; drugs; mass spectrometry; nanomaterials; protein subunits; viruses;     Show all 8 Subjects
Abstract:
... Understanding capsid assembly is important because of its role in virus lifecycles and in applications to drug discovery and nanomaterial development. Many virus capsids are icosahedral, and assembly is thought to occur by the sequential addition of capsid protein subunits to a nucleus, with the final step completing the icosahedron. Almost nothing is known about the final (completion) step becaus ...
DOI:
10.1021/jacs.7b09932

7. Molecular evolution of hepatitis B vaccine escape variants in China, during 2000–2016

Author:
Wang, Jie; Qiu, Jing; Zhu, Yinwei; Zhou, Hui; Yu, Lugang; Ding, Yi; Zhang, Lige; Guo, Zhirong; Dong, Chen
Source:
Vaccine 2017 v.35 no.43 pp. 5808-5813
ISSN:
0264-410X
Subject:
Hepatitis B virus,   etc   ; evolution; genotype; hepatitis B; mutation; vaccination; vaccines; China;     Show all 8 Subjects
Abstract:
... Hepatitis B vaccine escape variants are the main threat to hepatitis B virus (HBV) infection in vaccination era worldwide. With 215 genotype B HBV and 313 genotype C HBV vaccine escape variants isolated from China during 2000–2016, we reported that genotype B HBV vaccine escape strains diverged in ∼1997 (95% HPD; 1987–2005), while genotype C HBV vaccine escape strains diverged in ∼1976 (95% HPD; 1 ...
DOI:
10.1016/j.vaccine.2017.09.030

8. Circulating microRNAs as potential biomarkers of HBV infection persistence

Author:
Chen, Jie; Wu, Xiaojuan; Cai, Bei; Su, Zhenzhen; Li, Lixin; An, Yunfei; Wang, Lanlan
Source:
Infection, genetics, and evolution 2017 v.54 pp. 152-157
ISSN:
1567-1348
Subject:
Hepatitis B virus,   etc   ; DNA microarrays; biomarkers; correlation; microRNA; patients; reverse transcriptase polymerase chain reaction; viruses;     Show all 8 Subjects
Abstract:
... To investigate different microRNA (miRNA) expression profile in patients of hepatitis B virus (HBV) infection compared with virus spontaneous clearance ones, and try to find new biomarker for diagnosis and treatment assessment.miRNA expression profiling was analyzed in patients with HBV infection and patients with virus spontaneous clearance by Affymetrix Gene Chip miRNA 4.0 Arrays. The differentl ...
DOI:
10.1016/j.meegid.2017.06.023

9. Heterogeneous recombination among Hepatitis B virus genotypes

Author:
Castelhano, Nadine; Araujo, Natalia M.; Arenas, Miguel
Source:
Infection, genetics, and evolution 2017 v.54 pp. 486-490
ISSN:
1567-1348
Subject:
Hepatitis B virus,   etc   ; disease outbreaks; drug resistance; genotype; mutation; nucleotide sequences; phylogeny; uncertainty; viruses;     Show all 9 Subjects
Abstract:
... The rapid evolution of Hepatitis B virus (HBV) through both evolutionary forces, mutation and recombination, allows this virus to generate a large variety of adapted variants at both intra and inter-host levels. It can, for instance, generate drug resistance or the diverse viral genotypes that currently exist in the HBV epidemics. Concerning the latter, it is known that recombination played a majo ...
DOI:
10.1016/j.meegid.2017.08.015

10. Zeaxanthin dipalmitate alleviates hepatic injury induced by superimposed chronic hepatitis B and non-alcoholic steatohepatitis in non-obese mice

Author:
Li, Jing-Jing; Gao, Hao; Lv, Yi; Li, Mian-Huan; Ren, Chao-Ran; So, Kwok-Fai; Xiao, Jia
Source:
Journal of Asian natural products research 2017 v.19 no.9 pp. 910-923
ISSN:
1477-2213
Subject:
Hepatitis B virus,   etc   ; chronic hepatitis B; diet; fatty liver; methionine; mice; models; therapeutics; transgenic animals; zeaxanthin;     Show all 10 Subjects
Abstract:
... A hepatitis B virus (HBV) transgenic mice model was used to establish the fatty liver superimposed model by feeding the methionine choline-deficient (MCD) diet for 8 weeks, with or without the gavage of 2 mg/kg zeaxanthin dipalmitate (ZD) three times per week. Both wild-type and HBV transgenic mice, with MCD diet, gained typical non-obese non-alcoholic steatohepatitis (NASH) and HBV symptoms. Coad ...
DOI:
10.1080/10286020.2017.1349759

11. Complete genome sequence of a hepatitis B virus isolate of genotype D2, subtype adrq+, from Brazil

Author:
Spitz, Natália; Moreira, AlineS.; Mello, FranciscoC. A.; Franz, HelenaCristina F.; Gomes, SelmaA.; Araujo, NataliaM.
Source:
Archives of virology 2017 v.162 no.6 pp. 1695-1700
ISSN:
0304-8608
Subject:
Hepatitis B virus,   etc   ; clones; genes; genotype; hepatitis B antigens; nucleotide sequences; nucleotides; surface antigens; Brazil;     Show all 9 Subjects
Abstract:
... Hepatitis B virus (HBV) has been classified into 10 distinct serological subtypes of the surface antigen (HBsAg) that can be predicted by sequencing of the corresponding S gene. HBV genotype D usually displays determinants of subtypes ayw2 or ayw3. On the other hand, subtype adrq+ has been found exclusively in association with genotype C. Here, we describe the first HBV genome (isolate BR32) belon ...
DOI:
10.1007/s00705-017-3269-5

12. Permissive, in vitro replication of hepatitis B virus genotype E

Author:
Ji, Xin; Zafrullah, Mohammad; Wiese, Nicholas; Hayden-Mixon, Tonya; Forbi, Joseph C.; Teo, Chong-Gee; Purdy, Michael A.
Source:
Journal of virological methods 2017 v.243 pp. 20-24
ISSN:
0166-0934
Subject:
Hepatitis B virus,   etc   ; antigens; genotype; hepatitis B; human cell lines; plasmids; transfection;     Show all 7 Subjects
Abstract:
... A cloned stable cell line, HepG2-HBVE6, was established following transfection of HepG2 cells with a retroviral plasmid into which a 1.1-fold genomic construct of hepatitis B virus (HBV) belonging to genotype E (HBV/E) was inserted. The cell line retains the entire HBV/E insert, and produces episomal HBV DNA. It expresses HBV pregenomic, preS1 and preS2/S transcripts, and sheds hepatitis B surface ...
DOI:
10.1016/j.jviromet.2017.01.016

13. Chronic hepatitis B: Immunological profile and current therapeutic vaccines in clinical trials

Author:
Lobaina, Yadira; Michel, Marie-Louise
Source:
Vaccine 2017 v.35 no.18 pp. 2308-2314
ISSN:
0264-410X
Subject:
Hepatitis B virus,   etc   ; antiviral agents; chronic hepatitis B; clinical trials; hepatoma; liver; patients; people; vaccination; vaccines;     Show all 10 Subjects
Abstract:
... More than 250million people worldwide are chronically infected with hepatitis B virus (CHB), and over half a million die each year due to CHB-associated liver complications such as cirrhosis and hepatocellular carcinoma. The translation of immunological knowledge about CHB into therapeutic strategies aiming to a sustainable hepatitis B virus (HBV) clearance has been challenging. In recent years, h ...
DOI:
10.1016/j.vaccine.2017.03.049

14. The nucleotide changes within HBV core promoter/precore during the first 12weeks of nucleos(t)ide treatment might be associated with a better virological response

Author:
Peng, Yaqin; Li, Yutang; Hou, Jinlin; Sun, Jian; Su, Mingze; Li, Yao; Xiang, Kuanhui; Yan, Ling; Zhuang, Hui; Li, Tong
Source:
Infection, genetics, and evolution 2017 v.49 pp. 116-121
ISSN:
1567-1348
Subject:
Hepatitis B virus,   etc   ; DNA; chronic hepatitis B; genotype; hepatitis B antigens; lamivudine; mutation; patients; therapeutics;     Show all 9 Subjects
Abstract:
... We aimed to study the dynamic changes of hepatitis B virus (HBV) core promoter/precore (CP/preC) sequences during antiviral treatment and their associations with virological responses.The baseline and 12-week CP/preC sequences (nts 1655–2014) were obtained from 52 chronic hepatitis B patients with positive hepatitis B e antigen (HBeAg), who received a 104-week lamivudine and adefovir dipivoxil com ...
DOI:
10.1016/j.meegid.2017.01.009

15. Impact of universal infant hepatitis B vaccination in the US-affiliated Pacific Islands, 1985–2015

Author:
Abara, W.E.; Collier, M.G.; Teshale, E.H.
Source:
Vaccine 2017 v.35 no.7 pp. 997-1000
ISSN:
0264-410X
Subject:
Hepatitis B virus,   etc   ; analysis of variance; children; hepatitis B; protective effect; vaccination; vaccines; Pacific Ocean Islands;     Show all 8 Subjects
Abstract:
... The US-affiliated Pacific Island countries (USAPI) is an endemic region for hepatitis B virus (HBV) infection. Universal infant hepatitis B vaccination was introduced in the USAPI in the mid-1980s to mitigate the HBV burden. We assessed the impact of universal infant vaccination on the HBV infection prevalence over time among children born in the 1980s, 1990s, and 2000s in the USAPI. Demographic a ...
DOI:
10.1016/j.vaccine.2017.01.020

16. Mechanisms of Hepatitis B Virus Persistence

Author:
Tsai, Kuen-Nan; Kuo, Cheng-Fu; Ou, Jing-Hsiung James
Source:
Trends in microbiology 2017
ISSN:
0966-842X
Subject:
Hepatitis B virus,   etc   ; antigens; children; immune system; innate immunity; intestinal microorganisms; people;     Show all 7 Subjects
Abstract:
... Hepatitis B virus (HBV) chronically infects 250 million people worldwide, resulting in nearly one million deaths annually. Studies in recent years have significantly improved our knowledge on the mechanisms of HBV persistence. HBV uses multiple pathways to harness host innate immunity to enhance its replication. It can also take advantage of the developing immune system and the not-yet-stabilized ...
DOI:
10.1016/j.tim.2017.07.006

17. Countries’ interest in a hepatitis B vaccine licensed for the controlled temperature chain; survey results from African and Western Pacific regions

Author:
Petit, Dörte; Tevi-Benissan, Carole; Woodring, Joseph; Hennessey, Karen; Kahn, Anna-Lea
Source:
Vaccine 2017 v.35 no.49 pp. 6866-6871
ISSN:
0264-410X
Subject:
Hepatitis B virus,   etc   ; chronic hepatitis B; issues and policy; prices; surveys; temperature; transportation; vaccination; vaccines; Africa; Pacific Ocean Islands;     Show all 11 Subjects
Abstract:
... Chronic hepatitis B infection can be prevented by hepatitis B vaccine birth dose (hepB-BD) given within 24 h after birth, followed by two hepatitis B vaccinations within the first year of life. Yet nearly half of World Health Organization (WHO) Member States do not provide a hepB-BD. Barriers are primarily attributed to vaccine storage and transportation, as well as high rates of home births. Deli ...
DOI:
10.1016/j.vaccine.2017.10.025
PubMed:
29132994
PubMed Central:
PMC5722051

18. HBV X Protein induces overexpression of HERV-W env through NF-κB in HepG2 cells

Author:
Liu, Cong; Liu, Lijuan; Wang, Xiuling; Liu, Youyi; Wang, Miao; Zhu, Fan
Source:
Virus genes 2017 v.53 no.6 pp. 797-806
ISSN:
0920-8569
Subject:
Hepatitis B virus,   etc   ; Retroviridae; chromosomes; hepatoma; human cell lines; humans; messenger RNA; transactivators; transcription factor NF-kappa B; trophoblast;     Show all 10 Subjects
Abstract:
... Human endogenous retrovirus W family (HERV-W) envelope (env) at chromosome 7 is highly expressed in the placenta and possesses fusogenic activity in trophoblast development. HERV-W env has been found to be overexpressed in some cancers and immune diseases. Viral transactivators can induce the overexpression of HERV-W env in human cell lines. Hepatitis B virus X protein (HBx) is believed to be a mu ...
DOI:
10.1007/s11262-017-1479-2

19. Virus–host interplay in hepatitis B virus infection and epigenetic treatment strategies

Author:
Hensel, Kai O.; Rendon, Julio C.; Navas, Maria‐Cristina; Rots, Marianne G.; Postberg, Jan
Source:
The FEBS journal 2017 v.284 no.21 pp. 3550-3572
ISSN:
1742-464X
Subject:
Hepatitis B virus,   etc   ; adverse effects; chronic hepatitis B; disease control; epigenetics; genome; host-pathogen relationships; pathogenicity; roads; viremia; virus replication;     Show all 11 Subjects
Abstract:
... Worldwide, chronic hepatitis B virus (HBV) infection is a major health problem and no cure exists. Importantly, hepatocyte intrusion by HBV particles results in a complex deregulation of both viral and host cellular genetic and epigenetic processes. Among the attempts to develop novel therapeutic approaches against HBV infection, several options targeting the epigenomic regulation of HBV replicati ...
DOI:
10.1111/febs.14094

20. Clonorchis sinensis infection and co-infection with the hepatitis B virus are important factors associated with cholangiocarcinoma and hepatocellular carcinoma

Author:
Shi, Yunliang; Jiang, Zhihua; Yang, Yichao; Zheng, Peiqiu; Wei, Haiyan; Lin, Yuan; Lv, Guoli; Yang, Qingli
Source:
Parasitology research 2017 v.116 no.10 pp. 2645-2649
ISSN:
0932-0113
Subject:
Hepatitis B virus,   etc   ; Clonorchis sinensis; eggs; enzyme-linked immunosorbent assay; hepatitis B; hepatoma; microscopy; mixed infection; patients; surgery;     Show all 10 Subjects
Abstract:
... To evaluate the contributions of Clonorchis sinensis and hepatitis B virus to the development of cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC), C. sinensis and hepatitis B virus infections in 20 clinical liver cancer cases from a C. sinensis- and hepatitis B virus-epidemic region were detected. Eight cases of ICC, 11 cases of HCC and one mixed ICC and HCC case were verified by CT, pa ...
DOI:
10.1007/s00436-017-5572-1
PubMed:
28801696
PubMed Central:
PMC5599464