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- Okano, Hideyuki, et al. Show all 3 Authors
- Molecular and cellular endocrinology 2017 v.439 pp. 213-223
- cell differentiation; children; energy expenditure; etiology; food intake; humans; hypothalamus; mice; mutants; physical activity; pituitary gland; stem cells; trophoblast
- ... The hypothalamic-pituitary axes are the coordinating centers for multiple endocrine gland functions and physiological processes. Defects in the hypothalamus or pituitary gland can cause reduced growth and severe short stature, affecting approximately 1 in 4000 children, and a large percentage of cases of pituitary hormone deficiencies do not have an identified genetic cause. SOX21 is a protein tha ...
- Okano, Hideyuki, et al. Show all 10 Authors
- Biochemical and biophysical research communications 2017 v.483 pp. 88-93
- Parkinson disease; induced pluripotent stem cells; lysosomes; mitochondria; models; neurons; phenotype; reactive oxygen species
- ... Patient-specific induced pluripotent stem cells (iPSCs) show promise for use as tools for in vitro modeling of Parkinson's disease. We sought to improve the efficiency of dopaminergic (DA) neuron induction from iPSCs by the using surface markers expressed in DA progenitors to increase the significance of the phenotypic analysis. By sorting for a CD184high/CD44- fraction during neural differentiati ...