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- Russell, David W., et al. Show all 4 Authors
- Cell 2017 v.171 pp. 1057-1071.e11
- 25-hydroxycholesterol; bacterial infections; cytosol; inflammasomes; inflammation; interferons; interleukin-1beta; lipid metabolism; lipopolysaccharides; macrophages; melanoma; mitochondria; mitochondrial DNA; transcription (genetics); transcription factors
- ... Type I interferon restrains interleukin-1β (IL-1β)-driven inflammation in macrophages by upregulating cholesterol-25-hydroxylase (Ch25h) and repressing SREBP transcription factors. However, the molecular links between lipid metabolism and IL-1β production remain obscure. Here, we demonstrate that production of 25-hydroxycholesterol (25-HC) by macrophages is required to prevent inflammasome activat ...
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