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- Sergeant, Susan, et al. Show all 6 Authors
- Nutrients 2017 v.9 no.11
- alpha-linolenic acid; biochemical pathways; biosynthesis; cannabinoids; carbon; dietary exposure; eicosanoids; enzymes; genes; genetic variation; human diseases; linoleic acid; metabolites; nutrition-genotype interaction; omega-3 fatty acids; pathophysiology; tissues
- ... Background: Dietary essential omega-6 (n-6) and omega-3 (n-3) 18 carbon (18C-) polyunsaturated fatty acids (PUFA), linoleic acid (LA) and α-linolenic acid (ALA), can be converted (utilizing desaturase and elongase enzymes encoded by FADS and ELOVL genes) to biologically-active long chain (LC; >20)-PUFAs by numerous cells and tissues. These n-6 and n-3 LC-PUFAs and their metabolites (ex, eicosanoid ...