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- Shi, Yaning, et al. Show all 5 Authors
- Journal of functional foods 2017 v.35 pp. 635-640
- anti-inflammatory activity; human cell lines; absorption; esterification; structure-activity relationships; sulfonic acids; daidzein; phosphorylation; antioxidant activity; mitogen-activated protein kinase
- ... To improve the activity of the isoflavone daidzein (1) and to explore its structure-activity relationship, new daidzein sulfonic acid ester derivatives (2–4) were synthesized. All three derivatives showed significantly enhanced anti-inflammatory activities by 100–10,000-fold over that of the parent daidzein in TNF-α-stimulated Caco-2 cells. Daidzein derivatives 2 and 3 showed the same anti-inflamm ...