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- Zhang, Chuanbao, et al. Show all 15 Authors
- Molecular cell 2017 v.65 no.5 pp. 917-931.e6
- acetylation; acetyltransferases; autophagy; brain; carcinogenesis; enzyme activity; glutamine; homeostasis; hypoxia; metabolism; patients; phosphatidylinositol 3-kinase; phosphoglycerate kinase; phosphorylation; prognosis; protein kinases
- ... Autophagy is crucial for maintaining cell homeostasis. However, the precise mechanism underlying autophagy initiation remains to be defined. Here, we demonstrate that glutamine deprivation and hypoxia result in inhibition of mTOR-mediated acetyl-transferase ARD1 S228 phosphorylation, leading to ARD1-dependent phosphoglycerate kinase 1 (PGK1) K388 acetylation and subsequent PGK1-mediated Beclin1 S3 ...
- PubMed Central: