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- Author:
- P. Ahmadi Pirshahid; C. Thisayakorn; T. Hemthanon; T. Suntorntanasat; C. Banchonglikitkul; J. Eiamwat; S. Sookwhan
- Source:
- Acta horticulturae 2016 v. no.1125 pp. 161-172
- ISSN:
- 0567-7572
- Subject:
- Cissus quadrangularis; acute toxicity; biomarkers; body weight; death; diclofenac; dietary exposure; drugs; edema; endothelium; ethanol; hemorrhage; histopathology; median effective concentration; medicinal plants; pain; patients; phenylephrine; poisoning; quality control; rats; subchronic toxicity; toxicity testing; traditional medicine
- Abstract:
- ... Cissus quadrangularis L. is a medicinal plant widely used in Thai traditional medicine, especially to alleviate hemorrhoids. The aim of the present study was to investigate acute oral toxicity, anti-inflammatory and venoconstrictive effects of a whole plant standardized ethanol extract from C. quadrangularis in rats, followed by the evaluation of safety and efficacy of enteric film coated tablets ...
- DOI:
- 10.17660/ActaHortic.2016.1125.20
- https://doi.org/10.17660/ActaHortic.2016.1125.20
- Author:
- Cyntia Ayumi Yokota Harayashiki; Amanda J. Reichelt-Brushett; Lei Liu; Paul Butcher
- Source:
- Chemosphere 2016 v.164 pp. 241-247
- ISSN:
- 0045-6535
- Subject:
- Penaeus monodon; acetylcholinesterase; anthropogenic activities; behavior change; biomarkers; dietary exposure; freshwater; glutathione transferase; human health; humans; mercury; postlarvae; predation; risk; shrimp; swimming; toxicity
- Abstract:
- ... Mercury is a metal naturally present in the environment with concentrations in aquatic systems increasing annually due to human activities. This represents a great concern mainly due to its high toxicity to organisms and consequences for human health. Most studies regarding the toxic effect of mercury have focussed on freshwater species using water as the exposure and uptake pathway. In contrast, ...
- DOI:
- 10.1016/j.chemosphere.2016.08.085
- https://doi.org/10.1016/j.chemosphere.2016.08.085
- Author:
- Manfred Beckmann; Annemiek M. Joosen; Michelle M. Clarke; Owen Mugridge; Gary Frost; Barbara Engel; Kathleen Taillart; Amanda J. Lloyd; John Draper; John K. Lodge
- Source:
- Molecular nutrition & food research 2016 v.60 no.2 pp. 444-457
- ISSN:
- 1613-4125
- Subject:
- acute exposure; biomarkers; blood; body mass index; correlation; dietary exposure; fasting; fatty acids; females; fructose; humans; ketone bodies; metabolome; metabolomics; public health; sucrose; urine
- Abstract:
- ... SCOPE: The intake of sucrose is of public health concern but limited information is available on the metabolic effects of short‐term exposure. Our aim was to use metabolomics to investigate the metabolic impact of acute sucrose exposure. METHODS AND RESULTS: We performed a randomized, parallel, single‐dose feeding study on healthy females (n = 90, aged 29.9 ± 4.7 years, BMI 23.3 ± 2.5 kg/m²) consu ...
- DOI:
- 10.1002/mnfr.201500495
- https://doi.org/10.1002/mnfr.201500495
- Author:
- Mei Qiu; Yaling Wang; Xiaobo Wang; Lijun Sun; Riying Ye; Defeng Xu; Zhe Dai; Ying Liu; Siyuan Bi; Yanpo Yao; Ravi Gooneratne
- Source:
- Aquaculture 2016 v.462 pp. 35-39
- ISSN:
- 0044-8486
- Subject:
- Fusarium; Litopenaeus vannamei; T-2 toxin; alanine transaminase; albumins; alkaline phosphatase; aspartate transaminase; biomarkers; body weight; bone marrow cells; diet; dietary exposure; dose response; enzyme activity; feeds; fungi; growth retardation; hemocytes; hepatocytes; hepatopancreas; histopathology; immune system; immunity; lipid content; microstructure; monophenol monooxygenase; screening; shrimp; shrimp meat; specific growth rate; survival rate; toxicity
- Abstract:
- ... T-2 toxin (T-2) is a trichothecene-A-type mycotoxin produced by the fungus Fusarium spp., which can contaminate animal feed. It is toxic to many living cells especially the hepatocytes and bone marrow cells. The effects of dietary T-2 on growth, biochemical and immunity parameters, and histopathological changes in the hepatopancreas of white shrimp (Litopenaeus vannamei) were studied. Shrimp with ...
- DOI:
- 10.1016/j.aquaculture.2016.04.032
- https://doi.org/10.1016/j.aquaculture.2016.04.032
- Author:
- Dirga Kumar Lamichhane; Jong-Han Leem; Hwan-Cheol Kim; Ji-Young Lee; Myung-Sook Park; Dal-Young Jung; Jung Keun Ko; Mina Ha; Yangho Kim; Yun-Chul Hong; Eun-Hee Ha
- Source:
- Public health nutrition 2016 v.19 no.14 pp. 2562-2571
- ISSN:
- 1475-2727
- Subject:
- Koreans; biomarkers; birth weight; carcinogens; children; chronic diseases; cohort studies; diabetes; dietary exposure; environmental health; head circumference; hypertension; maternal exposure; maternal nutrition; meat; mothers; placenta; polycyclic aromatic hydrocarbons; pregnancy; pregnant women; regression analysis; smoked meats; South Korea
- Abstract:
- ... Polycyclic aromatic hydrocarbons (PAH) are common dietary exposures that cross the human placenta and are classified as a probable human carcinogen. The aim of the present study was to investigate the potential impact of exposure to PAH-containing meat consumed during pregnancy on birth outcomes. Prospective birth cohort study. Only non-smoking women with singleton pregnancies, who were free from ...
- DOI:
- 10.1017/S1368980016000550
- PubMed:
- 27056033
- https://doi.org/10.1017/S1368980016000550
- Author:
- Chuan Hong; Xiaodan Yu; Jihong Liu; Yue Cheng; Sarah E. Rothenberg
- Source:
- Environmental research 2016 v.150 pp. 519-527
- ISSN:
- 0013-9351
- Subject:
- biomarkers; blood sampling; correlation; dietary exposure; fish; hairs; ingestion; markets; mercury; methylmercury compounds; mothers; parturition; pregnancy; rice; risk; shellfish; staple foods; China
- Abstract:
- ... Rice ingestion is an important dietary exposure pathway for methylmercury. There are few studies concerning prenatal methylmercury exposure through rice ingestion, yet the health risks are greatest to the developing fetus, and thus should be investigated.Our main objective was to quantify dietary methylmercury intake through rice and fish/shellfish ingestion among pregnant mothers living in southe ...
- DOI:
- 10.1016/j.envres.2016.06.038
- PubMed:
- 27423706
- PubMed Central:
- PMC5003649
- https://doi.org/10.1016/j.envres.2016.06.038
- Author:
- Kevin M. Cooper; Sarah F. Brennan; Jayne V. Woodside; Marie Cantwell; Xiaoxiao Guo; Mark Mooney; Christopher T. Elliott; Geraldine J. Cuskelly
- Source:
- Food and chemical toxicology 2016 v.91 pp. 100-107
- ISSN:
- 0278-6915
- Subject:
- adults; aromatic amines; biomarkers; blood; blood proteins; cooking; detection limit; dietary exposure; fasting; food intake; food records; foods; humans; hydrolysis; metabolomics; mutagenicity; proteomics; pyridines; toxicology; viability
- Abstract:
- ... Heterocyclic aromatic amines (HCA) are carcinogenic mutagens formed during cooking of protein-rich foods. HCA residues adducted to blood proteins have been postulated as biomarkers of HCA exposure. However, the viability of quantifying HCAs following hydrolytic release from adducts in vivo and correlation with dietary intake are unproven. To definitively assess the potential of labile HCA-protein ...
- DOI:
- 10.1016/j.fct.2016.03.006
- https://doi.org/10.1016/j.fct.2016.03.006
- Author:
- Zhao Yanbin; Zhang Kun; Fent Karl
- Source:
- Environmental Science & Technology 2016 v.50 no.18 pp. 10245-10254
- ISSN:
- 1520-5851
- Subject:
- Danio rerio; acetates; adrenal cortex hormones; adults; biomarkers; blood; blood glucose; brain; circadian rhythm; dietary exposure; fish; genes; gluconeogenesis; hatching; immune response; leukocyte count; risk; swimming; transcription (genetics)
- Abstract:
- ... Synthetic corticosteroids may pose an environmental risk to fish. Here, we describe multiend point responses of adult zebrafish (8 months old) upon 21-day exposure to a commonly prescribed corticosteroid, fludrocortisone acetate (FLU), at concentrations between 0.006 and 42 μg/L. No remarkable reproductive impacts were observed, while physiological effects, including plasma glucose level and blood ...
- DOI:
- 10.1021/acs.est.6b03436
- https://doi.org/10.1021/acs.est.6b03436
- Author:
- Fernanda Garcia Sampaio; Maria Lídia Carra; Claudio Martin Jonsson; Vitoria Teodoro Gonçalves; Genoefa Dal’Bo; Kátia Santos Damacena Nunes; José Henrique Valim; Bruno Stéfano Lima Dallago; Sonia Claudia do Nascimento de Queiroz; Felix Guillermo Reyes Reyes
- Source:
- Bulletin of environmental contamination and toxicology 2016 v.97 no.4 pp. 528-535
- ISSN:
- 0007-4861
- Subject:
- Oreochromis niloticus; biomarkers; body weight; catalase; dietary exposure; fish; fish culture; glutathione transferase; hematologic tests; juveniles; lipid peroxidation; medicated feeds; oral administration; oxidative stress
- Abstract:
- ... Sulfamethazine (SMZ) is one of the most commonly used sulfonamide compounds in fish farming, and its physiological effects on fish are unknown. SMZ was administered to juvenile Nile tilapia (Oreochromis niloticus) at a dose level of 422 mg kg⁻¹ body weight, for a period of 11 days, via medicated feed. Fish were divided into two groups, the control group (CG) and the group fed with SMZ in feed. The ...
- DOI:
- 10.1007/s00128-016-1837-0
- https://doi.org/10.1007/s00128-016-1837-0
- Author:
- Camila S. Silva; Ching-Wei Chang; Denita Williams; Patricia Porter-Gill; Gonçalo Gamboa da Costa; Luísa Camacho
- Source:
- Food and chemical toxicology 2016 v.98 pp. 11-16
- ISSN:
- 0278-6915
- Subject:
- biomarkers; blood serum; creatinine; dietary exposure; dose response; females; histopathology; kidneys; males; melamine; microRNA; nephrotoxicity; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; toxicology; urea nitrogen
- Abstract:
- ... We showed previously that a 28-day combined dietary exposure to melamine and cyanuric acid (MEL&CYA) induced kidney lesions in NCTR Fisher 344 (F344) rats. Histopathological changes were significant in females dosed with ≥240 ppm MEL&CYA and in males dosed with ≥180 ppm MEL&CYA; however, the nephrotoxicity biomarkers blood urea nitrogen (BUN) and serum creatinine (SCr) were increased only by ≥240 ...
- DOI:
- 10.1016/j.fct.2016.09.013
- PubMed:
- 27621052
- PubMed Central:
- PMC5086269
- https://doi.org/10.1016/j.fct.2016.09.013
- Author:
- Morgan Lizabeth Bender; Marianne Frantzen; Ireen Vieweg; Inger-Britt Falk-Petersen; Helge Kreutzer Johnsen; Geir Rudolfsen; Knut Erik Tollefsen; Paul Dubourg; Jasmine Nahrgang
- Source:
- Aquatic toxicology 2016 v.180 pp. 196-208
- ISSN:
- 0166-445X
- Subject:
- Boreogadus saida; adverse effects; bile; biomarkers; biotransformation; chronic exposure; cod (fish); diet; dietary exposure; dose response; energy; females; feral animals; germ cells; humans; keystone species; long term effects; males; maturity stage; metabolism; metabolites; petroleum; pollution; polycyclic aromatic hydrocarbons; risk; sexual maturity; spawning; sperm motility; testosterone; Arctic region
- Abstract:
- ... Increasing human activities in the Arctic raise the risk of petroleum pollution, thus posing an elevated risk for Arctic organisms to be chronically exposed to petroleum compounds. The endocrine disrupting properties of some of these compounds (i.e. polycyclic aromatic hydrocarbons [PAHs]) present in crude oil may have negative effects on the long and energy intensive reproductive development of p ...
- DOI:
- 10.1016/j.aquatox.2016.10.005
- https://doi.org/10.1016/j.aquatox.2016.10.005
- Author:
- Shaoyou Lu; Lu Ren; Jianzhang Fang; Jiajia Ji; Guihua Liu; Jianqing Zhang; Huimin Zhang; Ruorong Luo; Kai Lin; Ruifang Fan
- Source:
- Environmental science and pollution research international 2016 v.23 no.9 pp. 8484-8491
- ISSN:
- 0944-1344
- Subject:
- DNA; aluminum; antimony; arsenic; atomic absorption spectrometry; biomarkers; cadmium; case studies; college students; copper; dietary exposure; food intake; liquid chromatography; manganese; molybdenum; neoplasms; nickel; oxidative stress; selenium; spectrometers; strontium; thallium; urine; China
- Abstract:
- ... Many trace heavy elements are carcinogenic and increase the incidence of cancer. However, a comprehensive study of the correlation between multiple trace elements and DNA oxidative damage is still lacking. The aim of this study is to investigate the relationships between the body burden of multiple trace elements and DNA oxidative stress in college students in Guangzhou, China. Seventeen trace ele ...
- DOI:
- 10.1007/s11356-016-6104-8
- https://doi.org/10.1007/s11356-016-6104-8