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- Du, Juan, et al. Show all 5 Authors
- Biochemical and biophysical research communications 2016 v.470 pp. 690-696
- Human immunodeficiency virus 1; Human immunodeficiency virus 2; chickens; humans; proteins; ubiquitin-protein ligase; viruses
- ... Primate SAMHD1 proteins are potent inhibitors of viruses, including retroviruses such as HIV-1, HIV-2, and SIV. Vpx, a distinctive viral protein expressed by HIV-2 and some SIVs, induces SAMHD1 degradation by forming a Vpx-DCAF1-based ubiquitin ligase complex. Either the N- or the C-terminus of SAMHD1 is critical for Vpx-induced degradation, depending on the types of SAMHD1 and Vpx proteins. Howev ...