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You searched for: Publication year rev 7984-2016 Remove constraint Publication year rev: 7984-2016 Subject term Influenza A virus Remove constraint Subject term: Influenza A virus
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1. 6-(4-Amino-2-butyl-imidazoquinolyl)-norleucine: Toll-like receptor 7 and 8 agonist amino acid for self-adjuvanting peptide vaccine

Author:
Yoshio Fujita; Kazuyuki Hirai; Keigo Nishida; Hiroaki Taguchi
Source:
Amino acids 2016 v.48 no.5 pp. 1319-1329
ISSN:
0939-4451
Subject:
Influenza A virus; Toll-like receptor 7; Toll-like receptor 8; agonists; amino acids; antibodies; antigens; ligands; mice; peptides; pharmacology; subunit vaccines; vaccine adjuvants
Abstract:
... Generally, small peptides by themselves are weak to induce antibody responses. Toll-like receptor (TLR) ligands are attractive candidates of vaccine adjuvants to improve their antigenicity. The covalent conjugation of TLR ligands with antigens to produce self-adjuvanting peptide vaccine is a promising approach. Based on the structure of TLR7/8 ligands, a series of synthetic amino acids 6-imidazoqu ...
DOI:
10.1007/s00726-016-2190-7

2. A Refined Guinea Pig Model of Foot‐and‐Mouth Disease Virus Infection for Assessing the Efficacy of Antiviral Compounds

Author:
A. R. De Vleeschauwer; D. J. Lefebvre; T. Willems; G. Paul; A. Billiet; L. E. Murao; J. Neyts; N. Goris; K. De Clercq
Source:
Transboundary and emerging diseases 2016 v.63 no.2 pp. e205
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus; Influenza A virus; RNA; antiviral agents; antiviral properties; blood serum; cattle; foot-and-mouth disease; guinea pigs; in vivo studies; models; oral administration; vaccination; vaccines; virus replication; Europe
Abstract:
... An antiviral containment strategy for foot‐and‐mouth disease (FMD) outbreaks could support or replace current contingency plans in case of an outbreak in Europe and could spare many healthy animals from being pre‐emptively culled. Recently, substantial progress has been made towards the development of small molecule drugs that inhibit FMD virus (FMDV) replication in vitro. For the initial in vivo ...
DOI:
10.1111/tbed.12255

3. A Simulation-Based Evaluation of Premovement Active Surveillance Protocol Options for the Managed Movement of Turkeys to Slaughter During an Outbreak of Highly Pathogenic Avian Influenza in the United States

Author:
Todd Weaver J.; Malladi Sasidhar; Bonney Peter J.; Patyk Kelly A.; Bergeron Justin G.; Middleton Jamie L.; Alexander Catherine Y.; Goldsmith Timothy J.; Halvorson David A.
Source:
Avian diseases 2016 v.60 no.1s pp. 132-145
ISSN:
0005-2086
Subject:
Influenza A virus; avian influenza; biosecurity; business enterprises; disease models; flocks; genes; monitoring; reverse transcriptase polymerase chain reaction; risk; risk assessment; risk management; simulation models; slaughter; stakeholders; turkeys; United States
Abstract:
... Risk management decisions associated with live poultry movement during a highly pathogenic avian influenza (HPAI) outbreak should be carefully considered. Live turkey movements may pose a risk for disease spread. On the other hand, interruptions in scheduled movements can disrupt business continuity. The Secure Turkey Supply (STS) Plan was developed through an industry-government-academic collabor ...
DOI:
10.1637/11108-042415-Reg

4. A Systematic Review of the Comparative Epidemiology of Avian and Human Influenza A H5N1 and H7N9 – Lessons and Unanswered Questions

Author:
C. Bui; A. Bethmont; A. A. Chughtai; L. Gardner; S. Sarkar; S. Hassan; H. Seale; C. R. MacIntyre
Source:
Transboundary and emerging diseases 2016 v.63 no.6 pp. 602-620
ISSN:
1865-1674
Subject:
Influenza A virus; emerging diseases; epidemiology; farms; human influenza; human population; humans; migratory behavior; monitoring; poultry; poultry industry; respiratory system; systematic review; wild birds; China
Abstract:
... The aim of this work was to explore the comparative epidemiology of influenza viruses, H5N1 and H7N9, in both bird and human populations. Specifically, the article examines similarities and differences between the two viruses in their genetic characteristics, distribution patterns in human and bird populations and postulated mechanisms of global spread. In summary, H5N1 is pathogenic in birds, whi ...
DOI:
10.1111/tbed.12327

5. A duplex RT-PCR assay for detection of H9 subtype avian influenza viruses and infectious bronchitis viruses

Author:
Yan-di WEI; Wei-hua GAO; Hong-lei SUN; Chen-fang YU; Xing-yao PEI; Yi-peng SUN; Jin-hua LIU; Juan PU
Source:
Journal of integrative agriculture 2016 v.15 no.9 pp. 2105-2113
ISSN:
2095-3119
Subject:
DNA primers; Infectious bronchitis virus; Influenza A virus; chickens; egg production; eggs; financial economics; genes; hemagglutinins; infectious bronchitis; mixed infection; monitoring; nucleocapsid; pathogens; respiratory tract diseases; reverse transcriptase polymerase chain reaction; viruses; China
Abstract:
... H9 subtype avian influenza virus (AIV) and infectious bronchitis virus (IBV) are major pathogens circulating in poultry and have resulted in great economic losses due to respiratory disease and reduced egg production. As similar symptoms are elicited by the two pathogens, it is difficult for their differential diagnosis. So far, no reverse transcription-polymerase chain reaction (RT-PCR) assay has ...
DOI:
10.1016/S2095-3119(15)61316-8
PubMed:
32288952
PubMed Central:
PMC7128909

6. A highly immunogenic vaccine against A/H7N9 influenza virus

Author:
Weiping Cao; Justine S. Liepkalns; Ahmed O. Hassan; Ram P. Kamal; Amelia R. Hofstetter; Samuel Amoah; Jin Hyang Kim; Adrian J. Reber; James Stevens; Jacqueline M. Katz; Shivaprakash Gangappa; Ian A. York; Suresh K. Mittal; Suryaprakash Sambhara
Source:
Vaccine 2016 v.34 no.6 pp. 744-749
ISSN:
0264-410X
Subject:
Influenza A virus; animal models; antibodies; at-risk population; blood serum; cell-mediated immunity; hemagglutinins; human diseases; influenza; pandemic; vaccines; viruses
Abstract:
... Since the first case of human infection in March 2013, continued reports of H7N9 cases highlight a potential pandemic threat. Highly immunogenic vaccines to this virus are urgently needed to protect vulnerable populations who lack protective immunity. In this study, an egg- and adjuvant-independent adenoviral vector-based, hemagglutinin H7 subtype influenza vaccine (HAd-H7HA) demonstrated enhanced ...
DOI:
10.1016/j.vaccine.2015.12.062
PubMed:
26765287
PubMed Central:
PMC4735641

7. A membrane-based purification process for cell culture-derived influenza A virus

Author:
Thomas Weigel; Thomas Solomaier; Sebastian Wehmeyer; Alessa Peuker; Michael W. Wolff; Udo Reichl
Source:
Journal of biotechnology 2016 v.220 pp. 12-20
ISSN:
0168-1656
Subject:
DNA; Influenza A virus; anion exchange; binding capacity; cellulose; chromatography; digestion; humans; production technology; purification methods; salt tolerance; vaccines; viruses
Abstract:
... A simple membrane-based purification process for cell culture-derived influenza virus was established that relies on only two chromatographic unit operations to achieve the contamination limits required according to regulatory authorities. After clarification and concentration, a pseudo-affinity membrane adsorber (sulfated cellulose, SCMA) was applied for virus capture. The subsequent polishing st ...
DOI:
10.1016/j.jbiotec.2015.12.022

8. A natural component from Euphorbia humifusa Willd displays novel, broad-spectrum anti-influenza activity by blocking nuclear export of viral ribonucleoprotein

Author:
So Young Chang; Ji Hoon Park; Young Ho Kim; Jong Seong Kang; Ji-Young Min
Source:
Biochemical and biophysical research communications 2016 v.471 pp. 282-289
ISSN:
0006-291X
Subject:
Euphorbia; Influenza A virus; cytoplasm; dose response; drug resistance; fluorescent antibody technique; influenza; mechanism of action; mutation; nucleoproteins; oseltamivir; physiological transport; progeny; ribonucleoproteins; screening; sialidase; signal transduction; virion; viruses
Abstract:
... The need to develop anti-influenza drugs with novel antiviral mechanisms is urgent because of the rapid rate of antigenic mutation and the emergence of drug-resistant viruses. We identified a novel anti-influenza molecule by screening 861 plant-derived natural components using a high-throughput image-based assay that measures inhibition of the influenza virus infection. 1,3,4,6-tetra-O-galloyl-β-D ...
DOI:
10.1016/j.bbrc.2016.01.123

9. Activation of cross-reactive mucosal T and B cell responses in human nasopharynx-associated lymphoid tissue in vitro by Modified Vaccinia Ankara-vectored influenza vaccines

Author:
Jennifer Mullin; Muhammed S. Ahmed; Ravi Sharma; Navdeep Upile; Helen Beer; Priya Achar; Suttida Puksuriwong; Francesca Ferrara; Nigel Temperton; Paul McNamara; Teresa Lambe; Sarah C. Gilbert; Qibo Zhang
Source:
Vaccine 2016 v.34 no.14 pp. 1688-1695
ISSN:
0264-410X
Subject:
CD4-positive T-lymphocytes; Influenza A virus; antibodies; antigens; hemagglutinins; humans; immunity; influenza; nucleoproteins; pandemic; vaccine development; vaccines; vertebrate viruses
Abstract:
... Recent efforts have been focused on the development of vaccines that could induce broad immunity against influenza virus, either through T cell responses to conserved internal antigens or B cell response to cross-reactive haemagglutinin (HA). We studied the capacity of Modified Vaccinia Ankara (MVA)-vectored influenza vaccines to induce cross-reactive immunity to influenza virus in human nasophary ...
DOI:
10.1016/j.vaccine.2016.02.028

10. Adaptive amino acid substitutions enhance the virulence of a novel human H7N9 influenza virus in mice

Author:
Yongkun Zhao; Zhijun Yu; Linna Liu; Tiecheng Wang; Weiyang Sun; Chengyu Wang; Zhiping Xia; Yuwei Gao; Bo Zhou; Jun Qian; Xianzhu Xia
Source:
Veterinary microbiology 2016 v.187 pp. 8-14
ISSN:
0378-1135
Subject:
Influenza A virus; amino acid substitution; amino acids; genome; humans; mice; proteins; virulence; viruses
Abstract:
... To identify molecular features that confer enhanced H7N9 virulence in mammals, we independently generated three mouse-adapted variants of A/Shanghai/2/2013 (H7N9) by serial passage in mice. The mouse lethal doses (MLD50) of the mouse-adapted variants were reduced >1000–100000-fold when compared to the parental virus. Adapted variants displayed enhanced replication kinetics in vivo, and were capabl ...
DOI:
10.1016/j.vetmic.2016.02.027

11. Age is not a determinant factor in susceptibility of broilers to H5N2 clade 2.3.4.4 high pathogenicity avian influenza virus

Author:
Kateri Bertran; Dong-Hun Lee; Charles Balzli; Mary J. Pantin-Jackwood; Erica Spackman; David E. Swayne
Source:
Veterinary research 2016 v.47 no.1 pp. 116-127
ISSN:
1297-9716
Subject:
Influenza A virus; White Leghorn; animal age; avian influenza; biosecurity; broiler breeders; death; disease outbreaks; disease resistance; disease transmission; eggs; farms; genetic resistance; lethal dose; mortality; pathogenesis; pathogenicity; turkeys; viral shedding; viruses; Midwestern United States
Abstract:
... In 2014–2015, the US experienced an unprecedented outbreak of H5 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) virus. The H5N2 HPAI virus outbreak in the Midwest in 2015 affected commercial turkey and layer farms, but not broiler farms. To assess any potential genetic resistance of broilers and/or age-related effects, we investigated the pathogenesis and transmission of A/turkey/Minnesota ...
Handle:
10113/5729149
DOI:
DOI 10.1186/s13567-016-0401-6
PubMed:
27871330
PubMed Central:
PMC5117617

12. Amino acid substitutions occurring during adaptation of an emergent H5N6 avian influenza virus to mammals

Author:
Xiuming Peng; Haibo Wu; Xiaorong Peng; Xiaoxin Wu; Linfang Cheng; Fumin Liu; Shujing Ji; Nanping Wu
Source:
Archives of virology 2016 v.161 no.6 pp. 1665-1670
ISSN:
0304-8608
Subject:
Influenza A virus; amino acid substitution; human health; mice; mortality; pathogenicity; poultry industry; viral load; viruses
Abstract:
... Avian influenza viruses (AIVs) are known to cross species barriers, and emergent highly pathogenic H5N6 AIVs pose a serious threat to human health and the poultry industry. Here, we serially passaged an H5N6 virus 10 times in BALB/c mice. The pathogenicity of the wild-type 6D2 (WT-6D2) and mammal-adapted 6D2 strain (MA-6D2) were compared. The viral titer in multiple organs and the death rate for M ...
DOI:
10.1007/s00705-016-2826-7

13. An evaluation of biosecurity compliance levels and assessment of associated risk factors for highly pathogenic avian influenza H5N1 infection of live-bird-markets, Nigeria and Egypt

Author:
Olubunmi G. Fasanmi; Syed Sayeem U. Ahmed; Mutiu O. Oladele-Bukola; Abdelgawad S. El-Tahawy; Ahmed R. Elbestawy; Folorunso O. Fasina
Source:
Acta tropica 2016 v.164 pp. 321-328
ISSN:
0001-706X
Subject:
Influenza A virus; avian influenza; biosecurity; compliance; disinfection; epidemiology; hand washing; markets; regression analysis; risk factors; slaughter; wild birds; Egypt; Nigeria
Abstract:
... Live bird market (LBM) is integral component in the perpetuation of HPAI H5N1, while biosecurity is crucial and key to the prevention and control of infectious diseases. Biosecurity compliance level and risk factor assessments in 155LBMs was evaluated in Nigeria and Egypt through the administration of a 68-item biosecurity checklist, scored based on the modifications of previous qualitative data, ...
DOI:
10.1016/j.actatropica.2016.08.030

14. An immunoassay-based reverse-transcription loop-mediated isothermal amplification assay for the rapid detection of avian influenza H5N1 virus viremia

Author:
Yi Tang; Xu Yu; Hao Chen; Youxiang Diao
Source:
Biosensors & bioelectronics 2016 v.86 pp. 255-261
ISSN:
0956-5663
Subject:
Influenza A virus; avian influenza; biosensors; birds; blood sampling; detection limit; genes; humans; monitoring; monoclonal antibodies; pandemic; public health; quantitative analysis; quantitative polymerase chain reaction; rapid methods; reverse transcription loop-mediated isothermal amplification; risk; screening; viremia; virion; viruses
Abstract:
... Avian influenza virus (AIV) subtype H5N1 attracts particular consideration because it is a continuous threat to animals and public health systems. The viremia caused by AIV H5N1 infection may increase the risk of blood-borne transmission between humans. Therefore, there is a need to rapidly evaluate and implement screening measures for AIV H5N1 viremia that allows for rapid response to this potent ...
DOI:
10.1016/j.bios.2016.06.063

15. Analysis of the beta-propiolactone sensitivity and optimization of inactivation methods for human influenza H3N2 virus

Author:
Yutaka Sasaki; Naoto Yoshino; Shigehiro Sato; Yasushi Muraki
Source:
Journal of virological methods 2016 v.235 pp. 105-111
ISSN:
0166-0934
Subject:
Influenza A virus; hemagglutinins; human influenza; humans; pH; vaccine development; virion; viruses
Abstract:
... Beta-propiolactone (BPL) is used as an inactivating reagent for influenza virus in a number of countries. However, the treatment of viruses with BPL occasionally results in a decrease in the hemagglutinin (HA) titer, which complicates vaccine development. In the present study, we examined the biological and biochemical characteristics of human H1N1 and H3N2 viruses treated with BPL, and developed ...
DOI:
10.1016/j.jviromet.2016.04.013

16. Analysis of the immunogenicity and bioactivities of a split influenza A/H7N9 vaccine mixed with MF59 adjuvant in BALB/c mice

Author:
Huilin Ou; Hangping Yao; Wei Yao; Nanping Wu; Xiaoxin Wu; Chengcong Han; Linfang Cheng; Keda Chen; Honglin Chen; Lanjuan Li
Source:
Vaccine 2016 v.34 no.20 pp. 2362-2370
ISSN:
0264-410X
Subject:
Influenza A virus; adjuvants; alum; antibodies; antibody formation; antigens; avian influenza; bioactive properties; clinical trials; cytokines; genes; genetics; hemagglutinins; humans; humoral immunity; immunoglobulin G; manufacturing; mice; morbidity; mortality; sialidase; vaccines; viruses; China
Abstract:
... The H7N9 influenza virus caused significant mortality and morbidity in humans during an outbreak in China in 2013. A recombinant H7N9 influenza seed with hemagglutinin (HA) and neuraminidase (NA) gene segments from A/Zhejiang/DTID-ZJU01/2013(H7N9) and six internal protein gene segments from A/Puerto Rico/8/34(H1N1; PR8) were generated using reverse genetics. We sought to determine the immunogenic, ...
DOI:
10.1016/j.vaccine.2016.03.037

17. Antibodies to Influenza A Viruses in Gulls at Delaware Bay, USA

Author:
Guinn Kayla; Fojtik Alinde; Davis-Fields Nick; Poulson Rebecca L.; Krauss Scott; Webster Robert G.; Stallknecht David E.
Source:
Avian diseases 2016 v.60 no.1s pp. 341-345
ISSN:
0005-2086
Subject:
Influenza A virus; Laridae; Limulus polyphemus; beaches; direct contact; ducks; eggs; enzyme-linked immunosorbent assay; habitats; hemagglutination; neutralizing antibodies; serology; seroprevalence; viruses; Delaware Bay; United States
Abstract:
... Gulls are the known reservoir for H13 and H16 influenza A viruses (IAV) but also host a diversity of other IAV subtypes. Gulls also share habitats with both ducks and shorebirds, increasing the potential for cross-species IAV transmission. We serologically tested laughing gulls (Leucophaeus atricilla) collected at Delaware Bay during May when they were in direct contact with IAV-infected shorebird ...
DOI:
10.1637/11103-042115-Reg

18. Antigenic Characterization of H3 Subtypes of Avian Influenza A Viruses from North America

Author:
Bailey Elizabeth; Long Li-Ping; Zhao Nan; Hall Jeffrey S.; Baroch John A.; Nolting Jacqueline; Senter Lucy; Cunningham Frederick L.; Pharr G. Todd; Hanson Larry; Slemons Richard; DeLiberto Thomas J.; Wan Xiu-Feng
Source:
Avian diseases 2016 v.60 no.1s pp. 346-353
ISSN:
0005-2086
Subject:
Influenza A virus; antigenic variation; antiserum; chickens; dogs; ferrets; hemagglutination; horses; hosts; human population; humans; migratory birds; swine; viruses; waterfowl; North America
Abstract:
... Besides humans, H3 subtypes of influenza A viruses (IAVs) can infect various animal hosts, including avian, swine, equine, canine, and sea mammal species. These H3 viruses are both antigenically and genetically diverse. Here, we characterized the antigenic diversity of contemporary H3 avian IAVs recovered from migratory birds in North America. Hemagglutination inhibition (HI) assays were performed ...
DOI:
10.1637/11086-041015-RegR
PubMed:
27309078
PubMed Central:
PMC4911812

19. Antigenic Detection of Human Strain of Influenza Virus A (H3N2) in Swine Populations at Three Locations in Nigeria and Ghana during the Dry Early Months of 2014

Author:
O. A. Adeola; B. O. Olugasa; B. O. Emikpe
Source:
Zoonoses and public health 2016 v.63 no.2 pp. 106-111
ISSN:
1863-1959
Subject:
Influenza A virus; antigen detection; cities; early warning systems; enzyme-linked immunosorbent assay; hemagglutinins; humans; influenza; monoclonal antibodies; nose; pandemic; swine; vertebrate viruses; viruses; Ghana; Nigeria
Abstract:
... Since the first detection of human H3N2 influenza virus in Taiwanese pigs in 1970, infection of pigs with wholly human viruses has been known to occur in other parts of the world. These viruses, referred to as human‐like H3N2 viruses, have been known to cause clinical and subclinical infections of swine populations. Due to the paucity and complete unavailability of information on transmission of i ...
DOI:
10.1111/zph.12210

20. Antiviral Triterpenes from the Twigs and Leaves of Lyonia ovalifolia

Author:
Lv Xiao-Jing; Li Yong; Ma Shuang-Gang; Qu Jing; Liu Yun-Bao; Li Yu-Huan; Zhang Dan; Li Li; Yu Shi-Shan
Source:
Journal of natural products 2016 v.79 no.11 pp. 2824-2837
ISSN:
1520-6025
Subject:
inhibitory concentration 50; Enterovirus; nuclear magnetic resonance spectroscopy; X-ray diffraction; antiviral properties; Human alphaherpesvirus 1; Influenza A virus; triterpenoids; leaves; spectral analysis; branches; herpes simplex; Lyonia ovalifolia; glycosides; circular dichroism spectroscopy
Abstract:
... Eleven new 9,10-seco-cycloartan triterpene glycosides (1–11), seven new lanostane triterpene glycosides (12–18), and two new ursane triterpenoids (19–20) were isolated from the twigs and leaves of Lyonia ovalifolia. The structures of these compounds were elucidated by extensive MS and NMR spectroscopic analysis. The absolute configuration of compound 1a (the aglycone of 1) was established by X-ray ...
DOI:
10.1021/acs.jnatprod.6b00585