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- Lee, Seongsoo, et al. Show all 7 Authors
- Biochemical and biophysical research communications 2016
- Drosophila; amyotrophic lateral sclerosis; brain; mitochondria; models; motor neurons; muscles; mutants; pathogenesis; proteins; regulator genes; spinal cord
- ... Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease, characterized by progressive and selective loss of motor neurons in the brain and spinal cord. DNA/RNA-binding proteins such as TDP-43, FUS, and TAF15 have been linked with the sporadic and familial forms of ALS. However, the exact pathogenic mechanism of ALS is still unknown. Recently, we found that ALS-causing gene ...