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bone density
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bone strength
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- Author:
- Gengyang Shen; Hui Ren; Ting Qiu; De Liang; Qiushi Wei; Jingjing Tang; Zhida Zhang; Zhensong Yao; Wenhua Zhao; Xiaobing Jiang
- Source:
- Biochemical and biophysical research communications 2016 pp. -
- ISSN:
- 0006-291X
- Subject:
- absorption; biomechanics; blood serum; bone density; bone strength; dexamethasone; dual-energy X-ray absorptiometry; energy; females; osteoporosis; rats; therapeutics; vertebrae
- Abstract:
- ... Glucocorticoid (GC) withdrawal after a short-term use was common in clinical practice like immediate post-transplant period. However, previous studies without setting age-control group failed to determine whether the BMD recovery was sufficient and whether it is necessary to accept anti-osteoporosis therapy after GC withdrawal. The aim of this study was to investigate the effect of GC withdrawal o ...
- DOI:
- 10.1016/j.bbrc.2016.07.036
- https://doi.org/10.1016/j.bbrc.2016.07.036
- Author:
- Joanna Folwarczna; Aleksandra Janas; Maria Pytlik; Urszula Cegieła; Leszek Śliwiński; Zora Krivošíková; Kornélia Štefíková; Martin Gajdoš
- Source:
- Nutrients 2016 v.8 no.3 pp. -
- ISSN:
- 2072-6643
- Subject:
- animal disease models; blood glucose; blood serum; bone density; bone fractures; bone mineralization; bone strength; diabetes; females; glycemic effect; laboratory animals; mechanical properties; nicotinamide; rats; streptozotocin; trigonelline
- Abstract:
- ... Diabetes increases bone fracture risk. Trigonelline, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. The aim of the study was to investigate the effects of trigonelline on experimental diabetes-induced disorders in the rat skeletal system. Effects of trigonelline (50 mg/kg p.o. daily for four weeks) were investigated in three-month-old female Wistar ...
- DOI:
- 10.3390/nu8030133
- PubMed:
- 26950142
- PubMed Central:
- PMC4808862
- https://doi.org/10.3390/nu8030133
- Author:
- Z. Kiełbowicz; A. Piątek; P. Kuropka; E. Mytnik; A. Nikodem; J. Bieżyński; P. Skrzypczak; C. Pezowicz; J. Kuryszko; P. Reichert
- Source:
- Polish journal of veterinary sciences 2016 v.19 no.1 pp. 109-118
- ISSN:
- 2300-2557
- Subject:
- animal models; bone density; bone strength; cartilage; females; histology; methylprednisolone; mineral content; osteoporosis; sheep; therapeutics
- Abstract:
- ... The implementation of new methods of osteoporotic therapy requires tests on animal model. The use of sheep as model has numerous advantages over other animals. The aim of this study was to describe the change in parameters in sheep with osteoporosis induced using steroids and ovariorectomy methods as opposed to the parameters in healthy sheep. The study was performed on female „merinos” breed shee ...
- DOI:
- 10.1515/pjvs-2016-0014
- https://doi.org/10.1515/pjvs-2016-0014
- Author:
- A. Stratmann; E.K.F. Fröhlich; S.G. Gebhardt-Henrich; A. Harlander-Matauschek; H. Würbel; M.J. Toscano
- Source:
- Poultry science 2016 v.95 no.5 pp. 975-984
- ISSN:
- 0032-5791
- Subject:
- aviaries; body weight; bone density; bone strength; egg masses; egg quality; egg shell; eggs; genetic lines; genetic selection; hybrids; keel bone; mortality; slaughter
- Abstract:
- ... The prevalence of keel bone damage as well as external egg parameters of 2 pure lines divergently selected for high (H) and low (L) bone strength were investigated in 2 aviary systems under commercial conditions. A standard LSL hybrid was used as a reference group. Birds were kept mixed per genetic line (77 hens of the H and L line and 201 or 206 hens of the LSL line, respectively, per pen) in 8 p ...
- DOI:
- 10.3382/ps/pew026
- https://doi.org/10.3382/ps/pew026
- Author:
- Douglas J. Adams; David W. Rowe; Cheryl L. Ackert-Bicknell
- Source:
- Mammalian genome 2016 v.27 no.7-8 pp. 367-380
- ISSN:
- 0938-8990
- Subject:
- bone density; bone resorption; bone strength; chromosome mapping; genes; humans; loci; risk; rodents; skeleton
- Abstract:
- ... With aging, the skeleton experiences a number of changes, which include reductions in mass and changes in matrix composition, leading to fragility and ultimately an increase of fracture risk. A number of aspects of bone physiology are controlled by genetic factors, including peak bone mass, bone shape, and composition; however, forward genetic studies in humans have largely concentrated on clinica ...
- DOI:
- 10.1007/s00335-016-9650-y
- PubMed:
- 27272104
- PubMed Central:
- PMC4948189
- https://doi.org/10.1007/s00335-016-9650-y
- Author:
- Yuno Oku; Rieko Tanabe; Kanae Nakaoka; Asako Yamada; Seiko Noda; Ayumi Hoshino; Mayu Haraikawa; Masae Goseki-Sone
- Source:
- Journal of nutritional biochemistry 2016 v.32 pp. 85-90
- ISSN:
- 0955-2863
- Subject:
- bone density; bone metabolism; bone strength; experimental diets; femur; gene expression; high fat diet; males; messenger RNA; muscles; osteoporosis; rats; risk; sarcopenia; skeletal muscle; transcription factors; visceral fat; vitamin D
- Abstract:
- ... Vitamin D insufficiency is associated with a greater risk of osteoporosis and also influences skeletal muscle functions, differentiation and development. The present study investigated the influences of vitamin D restriction on the body composition, bone and skeletal muscle in rats fed a high-fat diet. Sprague–Dawley strain male rats (11weeks old) were divided into four groups and fed experimental ...
- DOI:
- 10.1016/j.jnutbio.2016.01.013
- https://doi.org/10.1016/j.jnutbio.2016.01.013
- Author:
- Yubo Guo; Lili Wang; Rufeng Ma; Qianqian Mu; Na Yu; Yi Zhang; Yuqing Tang; Yu Li; Guangjian Jiang; Dandan Zhao; Fangfang Mo; Sihua Gao; Meijuan Yang; Feifei Kan; Qun Ma; Min Fu; Dongwei Zhang
- Source:
- Life sciences 2016 v.148 pp. 24-30
- ISSN:
- 0024-3205
- Subject:
- Western blotting; alizarin; alkaline phosphatase; animal disease models; bone density; bone formation; bone fractures; bone resorption; bone strength; calcification; calcium; cathepsin K; diabetes; femur; high fat diet; immunohistochemistry; insulin; insulin-like growth factor I; mice; staining; tibia
- Abstract:
- ... To assess the beneficial effects of JiangTang XiaoKe (JTXK) granule on the bone metabolism in high fat diet (HFD) fed KK-Ay diabetic mice.The KK-Ay mice were used as a diabetic model, while C57BL/6 mice were utilized as the non-diabetic control. The left tibia was used for determining bone mineral density (BMD) and bone ash coefficient. The HE and alizarin red S staining of femur were employed to ...
- DOI:
- 10.1016/j.lfs.2016.02.056
- https://doi.org/10.1016/j.lfs.2016.02.056
- Author:
- Hussam A. S. Murad
- Source:
- Journal of Zhejiang University 2016 v.17 no.1 pp. 43-53
- ISSN:
- 1673-1581
- Subject:
- blood serum; bone density; bone strength; coenzyme Q10; creatine kinase; estradiol; females; femur; histopathology; mineral content; muscles; muscular diseases; osteoporosis; ovariectomy; patients; rats; China
- Abstract:
- ... OBJECTIVE: Statins’ therapy in osteoporosis can aggravate muscle damage. This study was designed to assess which agent, L-carnitine or coenzyme Q10, could enhance the anti-osteoporotic effect of atorvastatin while antagonizing myopathy in ovariectomized rats. METHODS: Forty-eight female Sprague Dawley rats were used; forty rats were ovariectomized while eight were sham-operated. Eight weeks post-o ...
- DOI:
- 10.1631/jzus.B1500065
- PubMed:
- 26739525
- PubMed Central:
- PMC4710839
- https://doi.org/10.1631/jzus.B1500065
- Author:
- Marcin R. Tatara; Witold Krupski; Anna Charuta; Adam Brodzki; Artur Jóźwik; Nina Strzałkowska; Ewa Poławska; Krzysztof Chmielowiec; Jarosław O. Horbańczuk
- Source:
- Poultry science 2016 v.95 no.10 pp. 2421-2426
- ISSN:
- 0032-5791
- Subject:
- Struthio camelus; animal morphology; bone density; bone mineralization; bone strength; densitometry; dual-energy X-ray absorptiometry; females; femur; mechanical properties; metatarsus; micro-computed tomography; mineral content; ostriches; pelvic bones; tibia
- Abstract:
- ... Limited information on physiological characteristic of bones in ostrich skeleton are available, even though bone weaknesses in ostriches are commonplace. Thus, the aim of this study was to evaluate morphological, densitometric, and mechanical properties of pelvic limb long bones (femur, tibia, and tarsometatarsus) in 14-month-old female ostriches (Struthio camelus var. domesticus). After the slaug ...
- DOI:
- 10.3382/ps/pew188
- https://doi.org/10.3382/ps/pew188
- Author:
- KE Dittmer; B Hitchcock; S McDougall; JC Hunnam
- Source:
- New Zealand veterinary journal 2016 v.64 no.4 pp. 230-237
- ISSN:
- 1176-0710
- Subject:
- blood serum; bone density; bone resorption; bone strength; calcium; computed tomography; copper; dairy heifers; euthanasia; histopathology; humeral fractures; humerus; lactation; liver; nutrient deficiencies; osteoporosis; pathophysiology; protein energy malnutrition; regression analysis; resorption; slaughter; New Zealand
- Abstract:
- ... AIMS: To investigate the pathophysiology of humeral fractures in first-lactation dairy heifers in the North Island of New Zealand. METHODS: Ten 2-year-old dairy heifers with humeral fractures were subject to euthanasia and the fractured and non-fractured contralateral humeri were collected. Humeri were also collected from 10 unaffected 2-year-old dairy heifers sent for slaughter. Humeri from heife ...
- DOI:
- 10.1080/00480169.2016.1171173
- https://doi.org/10.1080/00480169.2016.1171173
- Author:
- Hwa-Young Lee; Han-Jung Chae; Sun-Young Park; Jong-Hyun Kim
- Source:
- BMC complementary and alternative medicine 2016 v.16 no.1 pp. 291
- ISSN:
- 1472-6882
- Subject:
- NAD(P)H oxidase (H2O2-forming); RNA; alkaline phosphatase; alternative medicine; antioxidant activity; apoptosis; bone density; bone metabolism; bone strength; caspases; cell viability; enzyme activity; hydrogen peroxide; hydrolysates; immunoblotting; osteoblasts; osteocalcin; osteoporosis; placenta; reverse transcriptase polymerase chain reaction; superoxide dismutase; swine
- Abstract:
- ... BACKGROUND: Osteoporosis is a disease characterized by decreased bone strength, decreased bone mass, and bone deterioration. Oxidative damage is an important contributor to functional changes in the development of osteoporosis. Here we found that porcine placenta hydrolysates (PPHs) protect MC3T3-E1 osteoblastic cells against hydrogen peroxide (H₂O₂)-induced oxidative damage. METHODS: In vitro cel ...
- DOI:
- 10.1186/s12906-016-1274-y
- PubMed:
- 27535035
- PubMed Central:
- PMC4989514
- https://doi.org/10.1186/s12906-016-1274-y
- Author:
- Kirsten N. Bott; Sandra M. Sacco; Patrick C. Turnbull; Amanda B. Longo; Wendy E. Ward; Sandra J. Peters
- Source:
- Applied Physiology, Nutrition, and Metabolism 2016 v.41 no.6 pp. 597-604
- ISSN:
- 1715-5320
- Subject:
- bone density; bone strength; dual-energy X-ray absorptiometry; food intake; males; mandible (bone); mastication; materials testing; metabolism; micro-computed tomography; rats; skeleton; tibia; vertebrae
- Abstract:
- ... Bone microarchitecture, bone mineral density (BMD), and bone strength are affected positively by impact activities such as running; however, there are discrepancies in the magnitude of these effects. These inconsistencies are mainly a result of varying training protocols, analysis techniques, and whether or not the skeletal sites measured are weight bearing. This study’s purpose was to determine t ...
- DOI:
- 10.1139/apnm-2015-0404
- https://doi.org/10.1139/apnm-2015-0404
- Author:
- Ya Yang; Yehong Huang; Li Zhang; Chi Zhang
- Source:
- Biochemical and biophysical research communications 2016 v.476 pp. 574-579
- ISSN:
- 0006-291X
- Subject:
- bone density; bone formation; bone resorption; bone strength; developmental orthopedic disease; dose response; gene expression; genes; mice; mineralization; mutants; osteoblasts; osteoporosis; risk; small interfering RNA; stem cells; transcription (genetics); transcription factors; transfection
- Abstract:
- ... Osteoporosis is the most common metabolic bone disease characterized by decreased bone mass, decreased bone strength, and increased risk of fracture. It is due to unbalance between bone formation and bone resorption. Bone formation is a complex process which involves the differentiation of mesenchymal stem cells to osteoblasts. Osteoblasts produce a characteristic extracellular collagenous matrix ...
- DOI:
- 10.1016/j.bbrc.2016.05.164
- https://doi.org/10.1016/j.bbrc.2016.05.164