Publication year rev: 7984-2016 / Subject term: bone density

1. A method of determining bending properties of poultry long bones using beam analysis and micro-CT data

Author:: Patrick E. Vaughan; Michael W. Orth; Roger C. Haut; Darrin M. Karcher
Source:: Poultry science 2016 v.95 no.1 pp. 207-212
ISSN:: 0032-5791
Subject:: aviaries; biomechanics; bone density; bone health; equations; geometry; humans; micro-computed tomography
Abstract:: ... While conventional mechanical testing has been regarded as a gold standard for the evaluation of bone heath in numerous studies, with recent advances in medical imaging, virtual methods of biomechanics are rapidly evolving in the human literature. The objective of the current study was to evaluate the feasibility of determining the elastic and failure properties of poultry long bones using establi ...
DOI:: 10.3382/ps/pev345
: https://doi.org/10.3382/ps/pev345

2. A novel homozygous variant in SERPINH1 associated with a severe, lethal presentation of osteogenesis imperfecta with hydranencephaly

Author:: Charlotte Marshall; Jaime Lopez; Laura Crookes; Rebecca C Pollitt; Meena Balasubramanian
Source:: Gene 2016 v.595 no.1 pp. 49-52
ISSN:: 0378-1119
Subject:: heat shock proteins; mechanism of action; mineralization; phenotype; collagen; bone formation; genetic disorders; bone density; children; patients; ribs; homozygosity; inheritance (genetics); exons; Mexico
Abstract:: ... Osteogenesis imperfecta (OI) is a genetic disorder characterised by low bone mineral density resulting in fractures. 85–90% of patients with OI carry a variant in the type 1 collagen genes, COL1A1 and COL1A2, which follows an autosomal dominant pattern of inheritance. However, within the last two decades, there have been growing number of variants identified in genes that follow an autosomal reces ...
DOI:: 10.1016/j.gene.2016.09.035
: https://doi.org/10.1016/j.gene.2016.09.035

3. Alendronate-loaded hydroxyapatite-TiO₂ nanotubes for improved bone formation in osteoporotic rabbits

Author:: Xinkun Shen; Pingping Ma; Yan Hu; Gaoqiang Xu; Kui Xu; Weizhen Chen; Qichun Ran; Liangliang Dai; Yonglin Yu; Caiyun Mu; Kaiyong Cai
Source:: Journal of materials chemistry B 2016 v.4 no.8 pp. 1423-1436
ISSN:: 2050-7518
Subject:: acid phosphatase; acidity; alkaline phosphatase; bone density; bone formation; calcium; gene expression; in vitro studies; in vivo studies; micro-computed tomography; mineralization; nanotubes; orthopedics; osteoblasts; osteoclasts; osteoporosis; protein synthesis; rabbits; staining
Abstract:: ... Early mechanical fixation between an implant and native bone is critically important for successful orthopedic implantation, especially for hosts suffering osteoporosis with reduced bone mass. To endow a titanium-based implant with a desirable local anti-osteoporosis property for enhancing its early osseointegration, alendronate-loaded hydroxyapatite-TiO₂ nanotube (TNT-HA-Aln) substrates were fabr ...
DOI:: 10.1039/c5tb01956g
: https://doi.org/10.1039/c5tb01956g

4. Anthocyanin-Rich Blackcurrant Extract Attenuates Ovariectomy-Induced Bone Loss in Mice

Author:: Zheng Xi; Mun Sewhan; Lee Sang Gil; Vance Terrence M.; Hubert Patrice; Koo Sung I.; Lee Sun-Kyeong; Chun Ock K.
Source:: Journal of medicinal food 2016 v.19 no.4 pp. 390-397
ISSN:: 1557-7600
Subject:: animal models; anthocyanins; anti-inflammatory activity; biomarkers; black currants; blood serum; bone density; bone formation; bone marrow cells; bone resorption; diet; dual-energy X-ray absorptiometry; femur; mice; micro-computed tomography; ovariectomy; postmenopause; resorption
Abstract:: ... Although several animal and cell studies have indicated that blackcurrant anthocyanins exert antioxidative and anti-inflammatory properties, which could potentially improve bone mass, the effect of blackcurrant on bone health has not been reported yet. Thus, this study was aimed to evaluate the effect of blackcurrant anthocyanins on bone mass in an estrogen deficiency mouse model. Fourteen-week-ol ...
DOI:: 10.1089/jmf.2015.0148
: https://doi.org/10.1089/jmf.2015.0148

5. Association between dietary patterns and low bone mineral density among adults aged 50 years and above: findings from the North West Adelaide Health Study (NWAHS)

Author:: Yohannes Adama Melaku; Tiffany K. Gill; Robert Adams; Zumin Shi
Source:: British journal of nutrition 2016 v.116 no.8 pp. 1437-1446
ISSN:: 1475-2662
Subject:: Western diets; adults; beers; bone density; cohort studies; data collection; dual-energy X-ray absorptiometry; eating habits; eggs; energy intake; factor analysis; fish; fruits; high fat dairy products; legumes; lifestyle; males; milk; potatoes; poultry; red meat; snacks; soft drinks; sugars; takeout foods; white bread; Australia
Abstract:: ... Studies on the association between dietary patterns and bone mineral density (BMD) have reported inconsistent findings. Data from the North West Adelaide Health Study, a population-based cohort study undertaken in Australia, were used to assess this association among adults aged 50 years and above. In this specific study, 1182 adults (545 males, 45·9 %) had dietary data collected using a FFQ and a ...
DOI:: 10.1017/S0007114516003366
PubMed:: 27669817
: https://doi.org/10.1017/S0007114516003366

6. Association between the methylenetetrahydrofolate reductase c.677C>T polymorphism and bone mineral density: an updated meta-analysis

Author:: Hong-Zhuo Li; Wei Wang; Yi-Ling Liu; Xiao-Feng He
Source:: Molecular genetics and genomics 2016 v.291 no.1 pp. 169-180
ISSN:: 1617-4615
Subject:: Asians; Whites; bone density; cohort studies; femur; hips; lumbar spine; men; meta-analysis; methylenetetrahydrofolate reductase; models; postmenopause; women
Abstract:: ... Many studies have reported an association between the methylenetetrahydrofolate reductase (MTHFR) c.677C>T polymorphism and reduced bone mineral density (BMD), but results have been inconsistent. We, therefore, performed a meta-analysis to further explore this association. Twenty-one studies, comprising 33,045 subjects, analyzed the association of MTHFR c.677C>T with femoral neck BMD. Significant ...
DOI:: 10.1007/s00438-015-1101-z
: https://doi.org/10.1007/s00438-015-1101-z

7. Association of dietary and serum vitamin E with bone mineral density in middle-aged and elderly Chinese adults: a cross-sectional study

Author:: Wen-qi Shi; Jun Liu; Yi Cao; Ying-ying Zhu; Ke Guan; Yu-ming Chen
Source:: British journal of nutrition 2016 v.115 no.1 pp. 113-120
ISSN:: 1475-2662
Subject:: Chinese people; alpha-tocopherol; blood serum; bone density; bone health; cross-sectional studies; dual-energy X-ray absorptiometry; elderly; femur; food intake; hips; interviews; lumbar spine; men; neck; questionnaires; reversed-phase high performance liquid chromatography; women; China
Abstract:: ... Previous studies have suggested that vitamin E (VE) may affect bone health, but the findings have been inconclusive. We examined the relationship between VE status (in both diet and serum) and bone mineral density (BMD) among Chinese adults. This community-based study included 3203 adults (2178 women and 1025 men) aged 40–75 years from Guangzhou, People’s Republic of China. General and dietary int ...
DOI:: 10.1017/S0007114515004134
PubMed:: 26507315
: https://doi.org/10.1017/S0007114515004134

8. Associations of breast-feeding patterns and introduction of solid foods with childhood bone mass: The Generation R Study

Author:: Edith H. van den Hooven; Mounira Gharsalli; Denise H. M. Heppe; Hein Raat; Albert Hofman; Oscar H. Franco; Fernando Rivadeneira; Vincent W. V. Jaddoe
Source:: British journal of nutrition 2016 v.115 no.6 pp. 1024-1032
ISSN:: 1475-2662
Subject:: bone density; breast feeding; childhood; children; cohort studies; dual-energy X-ray absorptiometry; foods; mineral content; questionnaires; vitamin D
Abstract:: ... Breast-feeding has been associated with later bone health, but results from previous studies are inconsistent. We examined the associations of breast-feeding patterns and timing of introduction of solids with bone mass at the age of 6 years in a prospective cohort study among 4919 children. We collected information about duration and exclusiveness of breast-feeding and timing of introduction of an ...
DOI:: 10.1017/S0007114515005462
PubMed:: 26856234
: https://doi.org/10.1017/S0007114515005462

9. BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice

Author:: Kenta Watanabe; Michiko Hirata; Tsukasa Tominari; Chiho Matsumoto; Yasuyuki Endo; Gillian Murphy; Hideaki Nagase; Masaki Inada; Chisato Miyaura
Source:: Biochemical and biophysical research communications 2016 v.478 no.1 pp. 279-285
ISSN:: 0006-291X
Subject:: agonists; androgen receptors; atrophy; bone density; bone resorption; boron; estrogen receptors; females; femur; hydrophobicity; males; mice; osteoporosis; ovariectomy; seminal vesicles
Abstract:: ... Carboranes are a class of carbon-containing polyhedral boron cluster compounds with globular geometry and hydrophobic surface that interact with hormone receptors such as estrogen receptor (ER) and androgen receptor (AR). We have synthesized BA321, a novel carborane compound, which binds to AR. We found here that it also binds to ERs, ERα and ERβ. In orchidectomized (ORX) mice, femoral bone mass w ...
DOI:: 10.1016/j.bbrc.2016.07.027
: https://doi.org/10.1016/j.bbrc.2016.07.027

10. Behaviour, growth performance, foot pad quality, bone density, and carcass traits of broiler chickens reared with barrier perches and fed different dietary crude protein levels

Author:: C.J. Bench; M.A. Oryschak; D.R. Korver; E. Beltranena
Source:: Canadian journal of animal science 2016 v.97 no.2 pp. 268-280
ISSN:: 1918-1825
Subject:: average daily gain; body weight; bone density; breasts; broiler chickens; carcass weight; crude protein; dermatitis; diet; dressing percentage; feed intake; growth performance; meat; perch; rearing
Abstract:: ... Perches serve as a behavioural enrichment and may yield benefits on broiler foot health and growth performance. The benefit may be greater for birds fed high crude protein (HCP) diets, which results in poorer litter conditions. This study investigated the effect of two perch configurations (I shaped vs. X shaped, compared with no perch) and dietary crude protein (CP) level (standard vs. high) on b ...
DOI:: 10.1139/cjas-2015-0202
: https://doi.org/10.1139/cjas-2015-0202

11. Biomechanical evolution of solid bones in large animals: a microanatomical investigation

Author:: Alexandra Houssaye; Katja Waskow; Shoji Hayashi; Raphaël Cornette; Andrew H. Lee; John R. Hutchinson
Source:: Biological journal of the Linnean Society 2016 v.117 no.2 pp. 350-371
ISSN:: 0024-4066
Subject:: absorption; allometry; animals; aquatic organisms; biomechanics; bone density; cortex; energy; evolution; paleoecology; posture
Abstract:: ... Graviportal taxa show an allometric increase of the cross‐sectional area of supportive bones and are assumed to display microanatomical changes associated with an increase in bone mass. This evokes osteosclerosis (i.e. an increase in bone compactness observed in some aquatic amniotes). The present study investigates the changes in bones' microanatomical organization associated with graviportality ...
DOI:: 10.1111/bij.12660
: https://doi.org/10.1111/bij.12660

12. Body mass but not vitamin D status is associated with bone mineral content and density in young school children in northern Sweden

Author:: Frida K. Videhult; Inger Öhlund; Olle Hernell; Christina E. West
Source:: Food & nutrition research 2016 v.60 no.1 pp. 30045
ISSN:: 1654-661X
Subject:: blood serum; body mass index; bone density; bone health; boys; calcium; cross-sectional studies; energy; food frequency questionnaires; food records; girls; latitude; lean body mass; liquid chromatography; mass spectrometry; pedometer; physical activity; prospective studies; puberty; school children; summer; vitamin D; vitamin status; Sweden
Abstract:: ... High latitude of residence where sun exposure is limited affects vitamin D status. Although vitamin D levels have been associated with poor bone health, cut-off values for optimising bone health are yet to be decided. To assess vitamin D intake and status among young school children living at latitude 63–64 °N, in northern Sweden and to examine the association between vitamin D status and bone min ...
DOI:: 10.3402/fnr.v60.30045
: https://doi.org/10.3402/fnr.v60.30045

13. Bone density of elbow joints in Labrador retrievers and Golden retrievers: Comparison of healthy joints and joints with medial coronoid disease

Author:: A. Villamonte-Chevalier; W. Dingemanse; B.J.G. Broeckx; A. Van Caelenberg; A. Agut; L. Duchateau; H. van Bree; I. Gielen
Source:: veterinary journal 2016 v.216 pp. 1-7
ISSN:: 1090-0233
Subject:: Golden Retriever; Labrador Retriever; age; body weight; bone density; dogs; humerus
Abstract:: ... The aims of this study were: (1) to determine the inter-observer repeatability of particular regions of the canine elbow joints; (2) to assess the effect of age, bodyweight and breed on bone density in healthy young dogs; (3) to compare Hounsfield units (HU) and bone density (BD) measurements between normal elbow joints and diseased elbow joints; and (4) to determine the sensitivity and specificit ...
DOI:: 10.1016/j.tvjl.2016.06.005
: https://doi.org/10.1016/j.tvjl.2016.06.005

14. Bone health nutraceuticals alter microarray mRNA gene expression: A randomized, parallel, open-label clinical study

Author:: Yumei Lin; Valentina Kazlova; Shyam Ramakrishnan; Mary A. Murray; David Fast; Amitabh Chandra; Kevin W. Gellenbeck
Source:: Phytomedicine 2016 v.23 no.1 pp. 18-26
ISSN:: 0944-7113
Subject:: Dimorphandra; Glycyrrhiza glabra; Punica granatum; Vitis vinifera; blood; blood sampling; bone density; bone formation; bone morphogenetic proteins; bone resorption; cathepsin G; collagen; extracellular matrix; food intake; fruits; functional foods; gene expression; gene expression regulation; genes; grape seeds; heparan sulfate; hyaluronoglucosaminidase; licorice; messenger RNA; microarray technology; osteoblasts; plant extracts; polyphenols; pomegranates; postmenopause; proteoglycans; quercetin; vegetables; women
Abstract:: ... Dietary intake of fruits and vegetables has been suggested to have a role in promoting bone health. More specifically, the polyphenols they contain have been linked to physiological effects related to bone mineral density and bone metabolism. In this research, we use standard microarray analyses of peripheral whole blood from post-menopausal women treated with two fixed combinations of plant extra ...
DOI:: 10.1016/j.phymed.2015.11.011
: https://doi.org/10.1016/j.phymed.2015.11.011

15. CLA Has a Useful Effect on Bone Markers in Patients with Rheumatoid Arthritis

Author:: N. Aryaeian; F. Shahram; M. Djalali
Source:: Lipids 2016 v.51 no.12 pp. 1397-1405
ISSN:: 0024-4201
Subject:: bone density; chronic diseases; clinical trials; computer software; conjugated linoleic acid; diet; enzyme-linked immunosorbent assay; insulin-like growth factor I; isomers; medical history; nutrition assessment; oleic acid; osteocalcin; osteoporosis; patients; placebos; questionnaires; rheumatoid arthritis; risk; sunflower oil
Abstract:: ... Rheumatoid arthritis is a systemic, chronic disease which may increase the risk of osteoporosis. This study was carried out in order to examine the effect of conjugated linoleic acid (CLA) on bone markers in rheumatoid arthritis disease which is the most common autoimmune disease. The present study is a randomized double-blind clinical trial. Subjects included 52 patients with active rheumatoid ar ...
DOI:: 10.1007/s11745-016-4201-6
: https://doi.org/10.1007/s11745-016-4201-6

16. Can a healthy life prevent us from post-menopausal osteoporosis? Myths and truths

Author:: Soledad Herrero; Yolanda Pico
Source:: PharmaNutrition 2016 v.4 no.2 pp. 45-53
ISSN:: 2213-4344
Subject:: adverse effects; alternative medicine; ascorbic acid; biomarkers; bone density; bone resorption; calcium; children; clinical trials; drugs; eating habits; epidemiological studies; fish consumption; gender; green tea; isoflavones; mineral content; olive oil; osteoporosis; ovariectomy; physical activity; postmenopause; prunes; rats; risk factors; women
Abstract:: ... Postmenopausal osteoporosis is related to unmodifiable risk factors (genetics, race, gender and age). However, other controllable factors such as activity, body mass, hormone and calcium levels and dietary habits can reduce fracture risk. For example, significant increases in bone mass density have been linked to physical activity in children, supplements of Vitamin C taken for more than 10 years, ...
DOI:: 10.1016/j.phanu.2016.02.003
: https://doi.org/10.1016/j.phanu.2016.02.003

17. Collagens VI and XII form complexes mediating osteoblast interactions during osteogenesis

Author:: Yayoi Izu; Yoichi Ezura; Manuel Koch; David E. Birk; Masaki Noda
Source:: Cell and tissue research 2016 v.364 no.3 pp. 623-635
ISSN:: 0302-766X
Subject:: bone density; bone formation; cell communication; collagen; fluorescent antibody technique; genes; homeostasis; mice; muscle tissues; muscular dystrophy; mutation; osteoblasts; patients; phenotype
Abstract:: ... Bone formation is precisely regulated by cell-cell communication in osteoblasts. We have previously demonstrated that genetic deletion of Col6a1 or Col12a1 impairs osteoblast connections and/or communication in mice, resulting in bone mass reduction and bone fragility. Mutations of the genes encoding collagen VI cause Ullrich congenital muscular dystrophy (UCMD) and Bethlem myopathy (BM), which ha ...
DOI:: 10.1007/s00441-015-2345-y
PubMed:: 26753503
PubMed Central:: PMC4875952
: https://doi.org/10.1007/s00441-015-2345-y

18. Combinations of physical activity, sedentary behaviour and sleep: relationships with health indicators in school-aged children and youth1

Author:: Travis John Saunders; Casey Ellen Gray; Veronica Joan Poitras; Jean-Philippe Chaput; Ian Janssen; Peter T. Katzmarzyk; Timothy Olds; Sarah Connor Gorber; Michelle E. Kho; Margaret Sampson; Mark S. Tremblay; Valerie Carson
Source:: Applied Physiology, Nutrition, and Metabolism 2016 v.41 no.6 pp. S283
ISSN:: 1715-5320
Subject:: adiposity; biomarkers; bone density; cognition; cohort studies; cross-sectional studies; databases; distress; metabolism; nutrition; physical activity; physical fitness; risk; school children; self-esteem; sleep; systematic review; youth
Abstract:: ... The purpose of this systematic review was to determine how combinations of physical activity (PA), sedentary behaviour (SB), and sleep were associated with important health indicators in children and youth aged 5–17 years. Online databases (MEDLINE, EMBASE, SPORTdiscus, CINAHL, and PsycINFO) were searched for relevant studies examining the relationship between time spent engaging in different comb ...
DOI:: 10.1139/apnm-2015-0626
: https://doi.org/10.1139/apnm-2015-0626

19. Cysteic Acid in Dietary Keratin is Metabolized to Glutathione and Liver Taurine in a Rat Model of Human Digestion

Author:: Frances M. Wolber; Michelle McGrath; Felicity Jackson; Kim Wylie; Anne Broomfield
Source:: Nutrients 2016 v.8 no.2 pp. -
ISSN:: 2072-6643
Subject:: animal models; blood; body fat; bone density; casein; cecum; cysteic acid; cysteine; digestibility; digestible protein; feathers; food intake; glutathione; hemoglobin; keratin; leukocyte count; liver; poultry; poultry industry; protein content; rats; taurine; tissue weight; weight gain
Abstract:: ... Poultry feathers, consisting largely of keratin, are a low-value product of the poultry industry. The safety and digestibility of a dietary protein produced from keratin (KER) was compared to a cysteine-supplemented casein-based diet in a growing rat model for four weeks. KER proved to be an effective substitute for casein at 50% of the total dietary protein, with no changes in the rats’ food inta ...
DOI:: 10.3390/nu8020104
PubMed:: 26907334
PubMed Central:: PMC4772066
: https://doi.org/10.3390/nu8020104

20. Danshen enhanced the estrogenic effects of Qing E formula in ovariectomized rats

Author:: Jian-mei Zhang; Jin Li; Er-wei Liu; Hong Wang; Guan-wei Fan; Yue-fei Wang; Yan Zhu; Shang-wei Ma; Xiu-mei Gao
Source:: BMC complementary and alternative medicine 2016 v.16 no.1 pp. 181
ISSN:: 1472-6882
Subject:: Salvia miltiorrhiza; agonists; alternative medicine; blood; body weight; bone density; computed tomography; endometrium; epithelium; estrogen receptors; estrogenic properties; food intake; gene induction; low density lipoprotein cholesterol; luciferase; mammary glands; menopause; models; ovariectomy; pathophysiology; quality of life; rats; synergism; tibia; triacylglycerols
Abstract:: ... BACKGROUND: Menopause is characterized by a decrease in life quality due to the appearance of uncomfortable symptoms. Nowadays, Understanding menopause-associated pathophysiology and developing new strategies to improve the treatment of menopausal-associated symptoms is an important issue. Our study was to evaluate the synergistic effects of Danshen (salvia miltiorrhiza bunge) and the phytoestroge ...
DOI:: 10.1186/s12906-016-1146-5
PubMed:: 27339619
PubMed Central:: PMC4918020
: https://doi.org/10.1186/s12906-016-1146-5

21. Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women

Author:: Marlena C. Kruger; Yoke Mun Chan; Barbara Kuhn-Sherlock; Lee Ting Lau; ChinChin Lau; Y. S. Chin; Joanne M. Todd; Linda M. Schollum
Source:: European journal of nutrition 2016 v.55 no.5 pp. 1911-1921
ISSN:: 1436-6207
Subject:: biomarkers; blood serum; bone density; bone resorption; calcium; cholecalciferol; fortified foods; magnesium; milk; minerals; parathyroid hormone; postmenopause; premenopause; vitamin status; women; zinc
Abstract:: ... PURPOSE: To compare the effects of a high-calcium vitamin D-fortified milk with added FOS-inulin versus regular milk on serum parathyroid hormone, and bone turnover markers in premenopausal (Pre-M) and postmenopausal (PM) women over 12 weeks. METHODS: Premenopausal women (n = 136, mean age 41 (±5) years) and postmenopausal women [n = 121, mean age 59 (±4) years] were recruited, and each age group ...
DOI:: 10.1007/s00394-015-1007-x
: https://doi.org/10.1007/s00394-015-1007-x

22. Direct Covalent Grafting of Phytate to Titanium Surfaces through Ti–O–P Bonding Shows Bone Stimulating Surface Properties and Decreased Bacterial Adhesion

Author:: Córdoba Alba; Hierro-Oliva Margarita; Pacha-Olivenza Miguel Ángel; Fernández-Calderón María Coronada; Perelló Joan; Isern Bernat; González-Martín María Luisa; Monjo Marta; Ramis Joana M.
Source:: ACS Applied Materials & Interfaces 2016 v.8 no.18 pp. 11326-11335
ISSN:: 1944-8252
Subject:: X-ray photoelectron spectroscopy; adhesion; bacterial adhesion; bioactive properties; biofilm; bone density; bone resorption; chemical bonding; coatings; gamma radiation; hydroxyapatite; legumes; mass spectrometry; microorganisms; myo-inositol; nitric acid; pH; phytic acid; prostheses; seeds; storage time; titanium; titanium dioxide; vegetables; viability
Abstract:: ... Myo-inositol hexaphosphate, also called phytic acid or phytate (IP6), is a natural molecule abundant in vegetable seeds and legumes. Among other functions, IP6 inhibits bone resorption. It is adsorbed on the surface of hydroxyapatite, inhibiting its dissolution and decreasing the progressive loss of bone mass. We present here a method to directly functionalize Ti surfaces covalently with IP6, with ...
DOI:: 10.1021/acsami.6b02533
: https://doi.org/10.1021/acsami.6b02533

23. Effects of Proton Pump Inhibitor Administration and Intake of a Combination of Yogurt and Galactooligosaccharides on Bone and Mineral Metabolism in Rats

Author:: Satoshi Takasugi; Miho Shioyama; Masami Kitade; Masashi Nagata; Taketo Yamaji
Source:: Nutrients 2016 v.8 no.10 pp. -
ISSN:: 2072-6643
Subject:: adults; bioavailability; blood serum; bone density; calcium; drugs; experimental diets; femur; fibroblast growth factors; galactooligosaccharides; laboratory animals; males; mineral metabolism; phosphorus; proton pump inhibitors; rats; subcutaneous injection; vertebrae; yogurt
Abstract:: ... The aim of this study was to investigate the effects of proton pump inhibitor (PPI), the most potent acid-suppressing drug, administration and intake of a combination of yogurt and galactooligosaccharides (YG) on bone and mineral metabolism in adult rats. Twelve-week-old male Wistar rats were divided into three groups: a control group fed the control diet with vehicle administration, a PPI group f ...
DOI:: 10.3390/nu8100653
PubMed:: 27775655
PubMed Central:: PMC5084039
: https://doi.org/10.3390/nu8100653

24. Estrogen-like osteoprotective effects of glycine in in vitro and in vivo models of menopause

Author:: Min-Ho Kim; Hyung-Min Kim; Hyun-Ja Jeong
Source:: Amino acids 2016 v.48 no.3 pp. 791-800
ISSN:: 0939-4451
Subject:: alkaline phosphatase; amino acids; blood serum; bone density; cell proliferation; dose response; estradiol; gene expression; ingredients; menopause; messenger RNA; mice; minerals; models; oral administration; osteoblasts; ovariectomy; peptides; phosphorylation; placenta; weight gain
Abstract:: ... Recently, the placenta mesotherapy has been widely used to treat menopause. Placenta contains amino acids, peptides, minerals, and estrogen. Here, we investigated the estrogen-like osteoprotective effects of glycine (a main ingredient of placenta) in in vitro and in vivo models of menopause. We assessed the effect of glycine on MG-63 osteoblast cell line, MCF-7 estrogen-dependent cell line, and ov ...
DOI:: 10.1007/s00726-015-2127-6
: https://doi.org/10.1007/s00726-015-2127-6

25. Evaluation of chronological changes in bone fractures and age-related bone loss: A test case from Poland

Author:: Anna E. Spinek; Wiesław Lorkiewicz; Joanna Mietlińska; Ewa Sewerynek; Arkadiusz Kłys; David Caramelli; Elżbieta Żądzińska
Source:: Journal of archaeological science 2016 v.72 pp. 117-127
ISSN:: 0305-4403
Subject:: archaeology; bone density; bone fractures; bone resorption; calcitriol receptors; calcium; diet; females; genes; osteoporosis; physical activity; polymerase chain reaction; ultraviolet radiation; women; Poland
Abstract:: ... Paleopathological studies suggest different patterns of age-related bone loss and osteoporosis in past populations compared with those of modern times. However, the observed interpopulational differences are often difficult to interpret due to considerable environmental and biological heterogeneity between populations from which the analyzed skeletal samples come. In the present paper, we try to d ...
DOI:: 10.1016/j.jas.2016.06.007
: https://doi.org/10.1016/j.jas.2016.06.007

26. Experimental osteoporosis in sheep – mechanical and histological approach

Author:: Z. Kiełbowicz; A. Piątek; P. Kuropka; E. Mytnik; A. Nikodem; J. Bieżyński; P. Skrzypczak; C. Pezowicz; J. Kuryszko; P. Reichert
Source:: Polish journal of veterinary sciences 2016 v.19 no.1 pp. 109-118
ISSN:: 2300-2557
Subject:: animal models; bone density; bone strength; cartilage; females; histology; methylprednisolone; mineral content; osteoporosis; sheep; therapeutics
Abstract:: ... The implementation of new methods of osteoporotic therapy requires tests on animal model. The use of sheep as model has numerous advantages over other animals. The aim of this study was to describe the change in parameters in sheep with osteoporosis induced using steroids and ovariorectomy methods as opposed to the parameters in healthy sheep. The study was performed on female „merinos” breed shee ...
DOI:: 10.1515/pjvs-2016-0014
: https://doi.org/10.1515/pjvs-2016-0014

27. Fgf23 and parathyroid hormone signaling interact in kidney and bone

Author:: Olena Andrukhova; Carmen Streicher; Ute Zeitz; Reinhold G. Erben
Source:: Molecular and Cellular Endocrinology 2016 v.436 pp. 224-239
ISSN:: 0303-7207
Subject:: blood serum; bone density; calcium; complications (disease); cyclic AMP; diet; excretion; fibroblasts; genotype; hypocalcemia; lactose; mice; mineral metabolism; mitogen-activated protein kinase; mutants; osteoblasts; osteoclasts; parathyroid hormone; phosphorylation; proximal tubules; tibia; vitamin D
Abstract:: ... Fibroblast growth factor-23 (FGF23) is a bone-derived hormone, suppressing renal phosphate reabsorption and vitamin D hormone synthesis in proximal tubules, and stimulating calcium reabsorption in distal tubules of the kidney. Here, we analyzed the long term sequelae of deficient Fgf23 signaling on bone and mineral metabolism in 9-month-old mice lacking both Fgf23 or Klotho and a functioning vitam ...
DOI:: 10.1016/j.mce.2016.07.035
: https://doi.org/10.1016/j.mce.2016.07.035

28. High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice

Author:: Yang Wang; Peter Dellatore; Veronique Douard; Ling Qin; Malcolm Watford; Ronaldo P. Ferraris; Tiao Lin; Sue A. Shapses
Source:: Nutrition research 2016 v.36 pp. 742-750
ISSN:: 0271-5317
Subject:: absorption; adverse effects; body weight changes; bone density; calcium; cytochrome P-450; dietary fat; females; femur; genes; high fat diet; mice; mineral content; monounsaturated fatty acids; obesity; saturated fatty acids
Abstract:: ... Diet induced obesity has been shown to reduce bone mineral density (BMD) and Ca absorption. However, previous experiments have not examined the effect of high fat diet (HFD) in the absence of obesity or addressed the type of dietary fatty acids. The primary objective of this study was to determine the effects of different types of high fat feeding, without obesity, on fractional calcium absorption ...
DOI:: 10.1016/j.nutres.2016.03.002
PubMed:: 27262536
PubMed Central:: PMC4919156
: https://doi.org/10.1016/j.nutres.2016.03.002

29. Housing conditions alter properties of the tibia and humerus during the laying phase in Lohmann white Leghorn hens

Author:: P. Regmi; N. Smith; N. Nelson; R.C. Haut; M.W. Orth; D.M. Karcher
Source:: Poultry science 2016 v.95 no.1 pp. 198-206
ISSN:: 0032-5791
Subject:: White Leghorn; adulthood; aviaries; bone density; computed tomography; cortex; egg industry; geometry; humerus; mechanical properties; osteoporosis; resorption; tibia
Abstract:: ... Osteoporosis in caged hens is one driving factor for the United States egg industry to explore options regarding alternative housing systems for laying hens. The aim of our research was to study the influence of housing systems on tibiae and humeri of 77-week-old Lohmann White hens. Pullets raised in an aviary system were either continued in aviary hen systems (AV) or conventional cages (AC) where ...
DOI:: 10.3382/ps/pev209
: https://doi.org/10.3382/ps/pev209

30. Lean Mass and Body Fat Percentage Are Contradictory Predictors of Bone Mineral Density in Pre-Menopausal Pacific Island Women

Author:: Maria Casale; Pamela R. von Hurst; Kathryn L. Beck; Sarah Shultz; Marlena C. Kruger; Wendy O’Brien; Cathryn A. Conlon; Rozanne Kruger
Source:: Nutrients 2016 v.8 no.8 pp. -
ISSN:: 2072-6643
Subject:: adipose tissue; ascorbic acid; body fat; bone density; bone health; calcium; densitometry; dual-energy X-ray absorptiometry; food frequency questionnaires; food intake; muscle tissues; physical activity; premenopause; protein intake; regression analysis; variance; weight loss; women; Pacific Ocean Islands
Abstract:: ... Anecdotally, it is suggested that Pacific Island women have good bone mineral density (BMD) compared to other ethnicities; however, little evidence for this or for associated factors exists. This study aimed to explore associations between predictors of bone mineral density (BMD, g/cm2), in pre-menopausal Pacific Island women. Healthy pre-menopausal Pacific Island women (age 16–45 years) were recr ...
DOI:: 10.3390/nu8080470
PubMed:: 27483314
PubMed Central:: PMC4997383
: https://doi.org/10.3390/nu8080470

31. Low level laser therapy accelerates bone healing in spinal cord injured rats

Author:: Carla Christina Medalha; Ana Lúcia Yaeko Silva Santos; Suellen de Oliveira Veronez; Kelly Rossetti Fernandes; Angela Maria Paiva Magri; Ana Claudia Muniz Renno
Source:: Journal of photochemistry and photobiology 2016 v.159 pp. 179-185
ISSN:: 1011-1344
Subject:: animal injuries; biomechanics; bone density; bone resorption; females; models; morphometry; rats; risk; spinal cord; surgery; tibia; transcription factors
Abstract:: ... Bone loss occurs rapidly and consistently after the occurrence of a spinal cord injury (SCI), leading to a decrease in bone mineral density (BMD) and a higher risk of fractures. In this context, the stimulatory effects of low level laser therapy (LLLT) also known as photobiomodulation (PBM) have been highlighted, mainly due to its osteogenic potential. The aim of the present study was to evaluate ...
DOI:: 10.1016/j.jphotobiol.2016.03.041
: https://doi.org/10.1016/j.jphotobiol.2016.03.041

32. Maternal dietary vitamin D carry-over alters offspring growth, skeletal mineralisation and tissue mRNA expressions of genes related to vitamin D, calcium and phosphorus homoeostasis in swine

Author:: Laura A. Amundson; Laura L. Hernandez; Jimena Laporta; Thomas D. Crenshaw
Source:: British journal of nutrition 2016 v.116 no.5 pp. 774-787
ISSN:: 1475-2662
Subject:: bone density; breeding; calcium; cholecalciferol; colostrum; diet; femur; genes; humans; kidneys; lactation; long term effects; maternal effect; mechanical properties; messenger RNA; mineralization; models; osteocalcin; phosphorus; progeny; sows; weaning
Abstract:: ... Maternal dietary vitamin D carry-over effects were assessed in young pigs to characterise skeletal abnormalities in a diet-induced model of kyphosis. Bone abnormalities were previously induced and bone mineral density (BMD) reduced in offspring from sows fed diets with inadequate vitamin D₃. In a nested design, pigs from sows (n 23) fed diets with 0 (−D), 8·125 (+D) or 43·750 (++D) µg D₃/kg from b ...
DOI:: 10.1017/S0007114516002658
PubMed:: 27480125
: https://doi.org/10.1017/S0007114516002658

33. Methyl jasmolate treated buckwheat sprout powder enhances glucose metabolism by potentiating hepatic insulin signaling in estrogen-deficient rats

Author:: Hye Jeong Yang; Jeong Ho Lim; Kee Jae Park; Suna Kang; Da Sol Kim; Sunmin Park
Source:: Nutrition 2016 v.32 no.1 pp. 129-137
ISSN:: 0899-9007
Subject:: bioactive compounds; body weight; bone density; bone metabolism; buckwheat; buckwheat sprouts; dextrins; dietary supplements; energy expenditure; estrogens; femur; glucose; high fat diet; homeostasis; hyperglycemia; insulin; insulin resistance; lipids; metabolism; ovariectomy; phosphorylation; phytoalexins; polyphenols; rats; rutin; skin temperature; weight gain
Abstract:: ... Methyl jasmolate (MeJA)-treated vegetables produce higher concentrations of various bioactive compounds. We investigated whether long-term oral consumption of MeJA-treated and untreated buckwheat sprout powder improves energy, glucose, lipid, and bone metabolism induced by estrogen deficiency in ovariectomized (OVX) rats fed high-fat diets, and explored the mechanisms involved.OVX rats were divide ...
DOI:: 10.1016/j.nut.2015.07.012
: https://doi.org/10.1016/j.nut.2015.07.012

34. MiR-132 regulates osteogenic differentiation via downregulating Sirtuin1 in a peroxisome proliferator-activated receptor β/δ–dependent manner

Author:: Kai Gong; Bo Qu; Dongfa Liao; Da Liu; Cairu Wang; Jingsong Zhou; Xianming Pan
Source:: Biochemical and biophysical research communications 2016 v.478 no.1 pp. 260-267
ISSN:: 0006-291X
Subject:: alkaline phosphatase; bone density; bone formation; bone fractures; bone resorption; cultured cells; free fatty acids; genes; glucose; microRNA; noninsulin-dependent diabetes mellitus; osteoblasts; osteoporosis; peroxisome proliferator-activated receptors; small interfering RNA
Abstract:: ... MicroRNAs (miRNAs) play significant roles in multiple diseases by regulating the expression of their target genes. Type 2 diabetes mellitus (T2DM) is a chronic endocrine and metabolic disease with complex mechanisms. T2DM can result in diabetic osteoporosis (DO), which is characterized by bone loss, decreased bone mineral density and increased bone fractures. The promotion of osteogenic differenti ...
DOI:: 10.1016/j.bbrc.2016.07.057
: https://doi.org/10.1016/j.bbrc.2016.07.057

35. Micro‐CT Structural Analysis of the Canine Medial Coronoid Disease

Author:: Noel Fitzpatrick; Tanya C. Garcia; Anjolie Daryani; Judith Bertran; Shinya Watari; Kei Hayashi
Source:: Veterinary surgery 2016 v.45 no.3 pp. 336-346
ISSN:: 0161-3499
Subject:: body weight; bone density; dogs; micro-computed tomography; surgery
Abstract:: ... OBJECTIVE: To use micro‐computed tomography (CT) to evaluate the fissure–fracture pattern in dogs affected by medial coronoid disease (MCD). STUDY DESIGN: Prospective case‐controlled study. SAMPLE POPULATION: Client owned (n = 21) and cadaver dogs (n = 5). METHODS: Segments were excised by subtotal coronoid ostectomy from dogs with MCD. Two categories were identified: fissured (Fi) or fractured (F ...
DOI:: 10.1111/vsu.12449
: https://doi.org/10.1111/vsu.12449

36. Mutan: A mixed linkage α-[(1,3)- and (1,6)]-d-glucan from Streptococcus mutans, that induces osteoclast differentiation and promotes alveolar bone loss

Author:: Hyun-Jung Kwon; Jung Min Kim; Kook-Il Han; Eui-Gil Jung; Yong Hyun Kim; Bharat Bhusan Patnaik; Mi Sook Yoon; Sung Kyun Chung; Wan Jong Kim; Man-Deuk Han
Source:: Carbohydrate polymers 2016 v.137 pp. 561-569
ISSN:: 0144-8617
Subject:: Fourier transform infrared spectroscopy; Streptococcus mutans; bone density; bone resorption; chemokines; dose response; gene expression regulation; genes; glucose; inflammation; interleukin-1alpha; interleukin-1beta; interleukin-6; ligands; lipopolysaccharides; micro-computed tomography; microarray technology; models; morphometry; nuclear magnetic resonance spectroscopy; osteoclasts; periodontitis; rats
Abstract:: ... Mutan is an extracellular polysaccharide of Streptococcus mutans (S. mutans) that consists of α-(1,3)-linked glucose residues in main chains and α-(1,6) bonds in side chains. In the present study, mutan was isolated from S. mutans, and its structural characteristics were determined using Fourier-transform infrared spectroscopy (FT-IR) and 13C nuclear magnetic resonance (NMR) spectroscopy. The effe ...
DOI:: 10.1016/j.carbpol.2015.11.013
: https://doi.org/10.1016/j.carbpol.2015.11.013

37. Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation

Author:: Jing An; Hao Yang; Qian Zhang; Cuicui Liu; Jingjing Zhao; Lingling Zhang; Bo Chen
Source:: Life sciences 2016 v.147 pp. 46-58
ISSN:: 0024-3205
Subject:: Oriental traditional medicine; active ingredients; adverse effects; anthraquinones; bone density; bone formation; bone resorption; coumarins; developmental orthopedic disease; diterpenoids; flavonoids; glycosides; mitogen-activated protein kinase; monoterpenoids; nitric oxide; osteoblasts; osteoporosis; phenolic acids; phenols; research and development; sesquiterpenoids; signal transduction; transcription (genetics); transcription factors
Abstract:: ... Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling that is caused by more osteoclast-mediated bone resorption than osteoblast-mediated bone formation results in such pathologic bone disorder. Traditional Chinese medicines (TCM) have long been used to prevent and treat osteo ...
DOI:: 10.1016/j.lfs.2016.01.024
: https://doi.org/10.1016/j.lfs.2016.01.024

38. Osteoblastogenic activity of ark shell protein hydrolysates with low molecular weight in mouse mesenchymal stem cells

Author:: Jun-Ho Hyung; Chang-Bum Ahn; Jae-Young Je
Source:: RSC advances 2016 v.6 no.35 pp. 29365-29370
ISSN:: 2046-2069
Subject:: alkaline phosphatase; biomarkers; bone density; bone formation; bone morphogenetic proteins; collagen; functional foods; health promotion; humans; hydrolysis; ingredients; mesenchymal stromal cells; mice; mineralization; mitogen-activated protein kinase; molecular weight; osteocalcin; osteoporosis; protein hydrolysates
Abstract:: ... Aging of human bone is characterized by decreased bone formation and bone mass. In this study, ark shell protein hydrolysates (ASPHs) were prepared by peptic hydrolysis with optimal conditions and were fractionated into 3–10 kDa, 1–3 kDa and <1 kDa fractions. Modulating the effects of ASPH with low molecular weight (ASPH < 1 kDa), which exhibited the highest stimulation effect on alkaline phosphat ...
DOI:: 10.1039/c6ra00898d
: https://doi.org/10.1039/c6ra00898d

39. PUFAs, Bone Mineral Density, and Fragility Fracture: Findings from Human Studies

Author:: Amanda B Longo; Wendy E Ward
Source:: Advances in nutrition 2016 v.7 no.2 pp. 299-312
ISSN:: 2156-5376
Subject:: bone density; cell culture; eating habits; fatty fish; fish consumption; humans; inflammation; nutrition assessment; osteoporosis; polyunsaturated fatty acids; risk reduction
Abstract:: ... Osteoporosis is a global health problem that leads to an increased incidence of fragility fracture. Recent dietary patterns of Western populations include higher than recommended intakes of n–6 (ω-6) polyunsaturated fatty acids (PUFAs) relative to n–3 (ω-3) PUFAs that may result in a chronic state of sterile whole body inflammation. Findings from human bone cell culture experiments have revealed b ...
DOI:: 10.3945/an.115.009472
PubMed:: 26980813
PubMed Central:: PMC4785467
: https://doi.org/10.3945/an.115.009472

40. Periostin action in bone

Author:: Nicolas Bonnet; Patrick Garnero; Serge Ferrari
Source:: Molecular and Cellular Endocrinology 2016 v.432 pp. 75-82
ISSN:: 0303-7207
Subject:: asthma; biomarkers; blood serum; bone density; bone formation; infarction; insects; integrins; metastasis; mice; neoplasms; osteoblasts; osteoporosis; parathyroid hormone; postmenopause; receptors; renal failure; risk; skeleton
Abstract:: ... Periostin is a highly conserved matricellular protein that shares close homology with the insect cell adhesion molecule fasciclin 1. Periostin is expressed in a broad range of tissues including the skeleton, where it serves both as a structural molecule of the bone matrix and a signaling molecule through integrin receptors and Wnt-beta-catenin pathways whereby it stimulates osteoblast functions an ...
DOI:: 10.1016/j.mce.2015.12.014
: https://doi.org/10.1016/j.mce.2015.12.014

41. Porcine placenta hydrolysates enhance osteoblast differentiation through their antioxidant activity and effects on ER stress

Author:: Hwa-Young Lee; Han-Jung Chae; Sun-Young Park; Jong-Hyun Kim
Source:: BMC complementary and alternative medicine 2016 v.16 no.1 pp. 291
ISSN:: 1472-6882
Subject:: NAD(P)H oxidase (H2O2-forming); RNA; alkaline phosphatase; alternative medicine; antioxidant activity; apoptosis; bone density; bone metabolism; bone strength; caspases; cell viability; enzyme activity; hydrogen peroxide; hydrolysates; immunoblotting; osteoblasts; osteocalcin; osteoporosis; placenta; reverse transcriptase polymerase chain reaction; superoxide dismutase; swine
Abstract:: ... BACKGROUND: Osteoporosis is a disease characterized by decreased bone strength, decreased bone mass, and bone deterioration. Oxidative damage is an important contributor to functional changes in the development of osteoporosis. Here we found that porcine placenta hydrolysates (PPHs) protect MC3T3-E1 osteoblastic cells against hydrogen peroxide (H₂O₂)-induced oxidative damage. METHODS: In vitro cel ...
DOI:: 10.1186/s12906-016-1274-y
PubMed:: 27535035
PubMed Central:: PMC4989514
: https://doi.org/10.1186/s12906-016-1274-y

42. Preference for and use of oral enrichment objects in juvenile silver foxes (Vulpes vulpes)

Author:: Anne Lene Hovland; Anne Marit S. Rød; Tarja Koistinen; Leena Ahola
Source:: Applied animal behaviour science 2016 v.180 pp. 122-129
ISSN:: 0168-1591
Subject:: Vulpes vulpes; animal behavior; bone density; cages; cattle; durability; femur; foxes; juveniles; meat; straw
Abstract:: ... Providing captive foxes with relevant enrichment objects may support their ability to cope with barren housing systems and thus have positive welfare effects. The relevance of enrichment objects is, among others, related to animals’ preference that should be examined prior to supplementing their housing environment. In this study, we assessed 30 juvenile, singly housed silver foxes’ short-term pre ...
DOI:: 10.1016/j.applanim.2016.04.020
: https://doi.org/10.1016/j.applanim.2016.04.020

43. Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo : Clearwater Beach, FL, USA. 9-11 June 2016

Author:: Lalitha Ramaswamy; Supriya Velraja; Guillermo Escalante; Phil Harvey; Michelle Alencar; Bryan Haddock; Krzysztof Durkalec-Michalski; Jan Jeszka; Bogna Zawieja; Tomasz Podgórski; Ana Paula Trussardi Fayh; Alexandre Hideki Okano; Amanda Maria de Jesus Ferreira; Ralf Jäger; Martin Purpura; Roger C. Harris; Molly M. Krause; Kiley A. Lavanger; Nina O. Allen; Allison E. Lieb; Katie A. Mullen; Joan M. Eckerson; Elisa Morales; Jeffrey Forsse; Thomas Andre; Sarah McKinley; Paul Hwang; Grant Tinsley; Mike Spillane; Peter Grandjean; Darryn Willoughby; A. Jagim; G. Wright; J. Kisiolek; M. Meinking; J. Ochsenwald; M. Andre; M. T. Jones; J. M. Oliver; Victor Araújo Ferreira; Daniel Costa de Souza; Victor Oliveira Albuquerque dos Santos; Rodrigo Alberto Vieira Browne; Eduardo Caldas Costa; Suresh T. Mathews; Haley D. Bishop; Clara R. Bowen; Yishan Liang; Emily A. West; Rebecca R. Rogers; Mallory R. Marshall; John K. Petrella; A. Maleah Holland; Wesley C. Kephart; Petey W. Mumford; C. Brooks Mobley; Ryan P. Lowery; Jacob M. Wilson; Michael D. Roberts; Eric T. Trexler; Katie R. Hirsch; Bill I. Campbell; Meredith G. Mock; Abbie E. Smith-Ryan; Kate Zemek; Carol Johnston; David D. Pascoe; Christopher M. Lockwood; Michael E. Miller; Gabriel J. Sanders; Willard Peveler; Brooke Warning; Corey A. Peacock; David Sandler; Sara Perez Ojalvo; James Komorowski; Danielle Aguilar; Andres Vargas; Laurin Conlin; Amey Sanders; Paola Fink-Irizarry; Layne Norton; Ross Perry; Ryley McCallum; Matthew R. Wynn; Jack Lenton; Chris Gai; Seth Donelson; Shiva Best; Daniel Bove; Kaylee Couvillion; Jeff Dolan; Dante Xing; Kyshia Chernesky; Michael Pawela; Andres D. Toledo; Rachel Jimenez; M. Rabideau; A. Walker; J. Pellegrino; M. Hofacker; B. McFadden; S. Conway; C. Ordway; D. Sanders; R. Monaco; M. S. Fragala; S. M. Arent; Jason D. Stone; Andreas Kreutzer; Jonathan M. Oliver; Jacob Kisiolek; Andrew R. Jagim; Ozlem Tok; Joseph K. Pellegrino; Alan J. Walker; David J. Sanders; Bridget A. McFadden; Meaghan M. Rabideau; Sean P. Conway; Chris E. Ordway; Marissa Bello; Morgan L. Hofacker; Nick S. Mackowski; Anthony J. Poyssick; Eddie Capone; Robert M. Monaco; Maren S. Fragala; Shawn M. Arent; Romil K. Patel; Annie Newton; Darren T. Beck; Kaelin C. Young; Tobin Silver; Anya Ellerbroek; Richard Buehn; Leo Vargas; Armando Tamayo; Corey Peacock; Jose Antonio; Adam Pollock; A. Kreutzer; P. Zavala; S. Fleming; M. Jones; Cody T. Haun; Parker N. Hyde; Ciaran M. Fairman; Jordan R. Moon; Kristina L. Kendall; Geoffrey M. Hudson; Tara Hannings; Kyle Sprow; Loretta DiPietro; Doug Kalman; J. Oliver; Brian Wallace; Haley Bergstrom; Kelly Wallace; Matias Monsalves-Alvarez; Sebastian Oyharçabal; Victoria Espinoza; Trisha A. VanDusseldorp; Kurt A. Escobar; Kelly E. Johnson; Nathan Cole; Terence Moriarty; Matthew Stratton; Marvin R. Endito; Christine M. Mermier; Chad M. Kerksick; Matthew A. Romero; Melissa Linden; Grace Margaret-Eleanor Meers; R. Scott Rector; Joshua L Gills; Hocheng Lu; Kimberly Parker; Chris Dobbins; Joshua N. Guillory; Braden Romer; David Szymanski; Jordan Glenn; Daniel E. Newmire; Eric Rivas; Sarah E. Deemer; Robert Wildman; Victor Ben-Ezra; C. Kerksick; B. Gieske; R. Stecker; C. Smith; K. Witherbee; Michael T. Lane; M. Travis Byrd; Zachary Bell; Emily Frith; Lauren M. C. Lane; Tobin A. Silver; Megan Colas; Mauricio Mena; Winter Rodriguez; Andrea Vansickle; Brittany DiFiore; Stephanie Stepp; Grant Slack; Bridget Smith; Kayla Ruffner; Ronald Mendel; Lonnie Lowery; Malia M. N. Blue; Erica J. Roelofs; Katie Coles; Nic Martinez; Jordan M. Joy; Roxanne M. Vogel; Thomas H. Hoover; K. Shane Broughton; R. Dalton; R. Sowinski; T. Grubic; P. B. Collins; A. Colletta; A. Reyes; B. Sanchez; M. Kozehchain; Y. P. Jung; C. Rasmussen; P. Murano; C. P. Earnest; M. Greenwood; R. B. Kreider; Stacie Urbina; Emily Santos; Katelyn Villa; Alyssa Olivencia; Haley Bennett; Marissa Lara; Cliffa Foster; Colin Wilborn; Lem Taylor; Jason M Cholewa; Amy Hewins; Samantha Gallo; Ashley Micensky; Christian de Angelis; Christopher Carney; Bill Campbell; Fabricio Rossi; M. S. Koozehchian; A. O’Connor; S. Y. Shin; Y. Peter Jung; B. K. Sanchez; A. Coletta; M. Cho; P. S. Murano
Source:: Journal of the International Society of Sports Nutrition 2016 v.13 no.Supplement 1 pp. 33
ISSN:: 1550-2783
Subject:: Western diets; acute effects; adults; antioxidants; appetite; arginine; athletes; biogenesis; biomarkers; blood glucose; blood serum; body fat; body water; bone density; bone metabolism; breakfast; caffeine; calorimetry; casein; cognition; college students; colostrum; creatine; creatine kinase; cross-over studies; diet recall; dieting; distress; electrolytes; energy drinks; energy intake; equations; exosomes; females; femur; food intake; gastrointestinal system; glucose; high protein diet; hormones; insulin-like growth factor I; ketogenic diet; leucine; lipid composition; liver; males; men; molecular weight; muscles; nitrates; nitric oxide; nutrition monitoring; nutritional status; overweight; oxidation; oxygen consumption; peppermint oil; physical fitness; power generation; prediction; protein hydrolysates; protein intake; protein supplements; protein synthesis; rats; resting metabolic rate; ribosomes; risk factors; silicates; silicon; sodium bicarbonate; sports; sports nutrition; strength training; triacylglycerols; waist circumference; whey; whey protein; women; United States
Abstract:: ... TABLE OF CONTENTS: P1 Impact of antioxidant-enriched nutrient bar supplementation on the serum antioxidant markers and physical fitness components of track and field athletesLalitha Ramaswamy, Supriya VelrajaP2 The effects of phosphatidic acid supplementation on fitness levels in resistance trained womenGuillermo Escalante, Phil Harvey, Michelle Alencar, Bryan HaddockP3 The effects of phosphatidic ...
DOI:: 10.1186/s12970-016-0144-9
: https://doi.org/10.1186/s12970-016-0144-9

44. Quantitative comparison of bone mineral density characteristics of the distal epiphysis of third metacarpal bones from Thoroughbred racehorses with or without condylar fracture

Author:: Sophie H. Bogers; Chris W. Rogers; Charlotte Bolwell; Wendi Roe; Erica Gee; Wayne Mcllwraith
Source:: American journal of veterinary research 2016 v.77 no.1 pp. 32-38
ISSN:: 0002-9645
Subject:: Thoroughbred; bone density; computer software; epiphyses; image analysis; metacarpus; racehorses; spatial distribution; statistics
Abstract:: ... OBJECTIVE To compare regional proportions and spatial distributions of volumetric bone mineral density (BMDv) of the palmar aspect of the distal epiphysis of the third metacarpal bone (McIII) in limbs with or without a condylar fracture from Thoroughbred racehorses. SAMPLE McIIIs from cadavers of Thoroughbred racehorses with (n = 6 bones) and without (8) a condylar fracture. PROCEDURES BMDv and sp ...
DOI:: 10.2460/ajvr.77.1.32
: https://doi.org/10.2460/ajvr.77.1.32

45. Quantitative proteomics and integrative network analysis identified novel genes and pathways related to osteoporosis

Author:: Yong Zeng; Lan Zhang; Wei Zhu; Chao Xu; Hao He; Yu Zhou; Yao-Zhong Liu; Qing Tian; Ji-Gang Zhang; Fei-Yan Deng; Hong-Gang Hu; Li-Shu Zhang; Hong-Wen Deng
Source:: Journal of proteomics 2016 v.142 pp. 45-52
ISSN:: 1874-3919
Subject:: Whites; bone density; bone resorption; females; gene expression regulation; genes; genome-wide association study; microfilaments; monocytes; osteoclasts; osteoporosis; protein synthesis; proteomics; spectroscopy
Abstract:: ... Osteoporosis is mainly characterized by low bone mineral density (BMD), and can be attributed to excessive bone resorption by osteoclasts. Migration of circulating monocytes from blood to bone is important for subsequent osteoclast differentiation and bone resorption. Identification of those genes and pathways related to osteoclastogenesis and BMD will contribute to a better understanding of the p ...
DOI:: 10.1016/j.jprot.2016.04.044
PubMed:: 27153759
PubMed Central:: PMC5362378
: https://doi.org/10.1016/j.jprot.2016.04.044

46. Serum concentrations of 25-hydroxyvitamin D and its association with bone mineral density and serum parathyroid hormone levels during winter in urban males from Guiyang, Southwest China

Author:: Qiao Zhang; Lixin Shi; Nianchun Peng; Shujing Xu; Miao Zhang; Song Zhang; Hong Li; Huijun Zhuang; Mingxian Gong; Danrong Wu; Rui Wang
Source:: British journal of nutrition 2016 v.115 no.6 pp. 960-966
ISSN:: 1475-2662
Subject:: blood serum; bone density; covariance; femur; hips; lifestyle; lumbar spine; males; medical history; parathyroid hormone; socioeconomics; surveys; vitamin D; winter; China
Abstract:: ... Serum vitamin D (25-hydroxyvitamin D (25OHD)) may influence serum parathyroid hormone (PTH) levels and bone mineral density (BMD). In the present study, we assessed serum 25OHD concentration and its association with PTH and BMD in urban males from Guiyang (N26.57°), the capital city of Guizhou province, Southwest China. We recruited 634 males aged >20 years from the Guiyang Health Measures Survey, ...
DOI:: 10.1017/S0007114515005383
PubMed:: 26843386
: https://doi.org/10.1017/S0007114515005383

47. Sialoglycoprotein Isolated from Eggs of Carassius auratus Ameliorates Osteoporosis: An Effect Associated with Regulation of the Wnt/β-Catenin Pathway in Rodents

Author:: Fei Wang; Yiming Wang; Yanlei Zhao; Qiping Zhan; Peng Yu; Jingfeng Wang; Changhu Xue
Source:: Journal of agricultural and food chemistry 2016 v.64 no.14 pp. 2875-2882
ISSN:: 0021-8561
Subject:: Carassius auratus; biomechanics; bone density; bone formation; eggs; genes; metabolism; mice; microstructure; models; osteoblasts; osteoporosis; ovariectomy; postmenopause; rats
Abstract:: ... In the current study, ovariectomized (OVX) rats and the senescence-accelerated mouse strain P6 (SAMP6) were employed to establish models of postmenopausal osteoporosis and senile osteoporosis, respectively. The effects of treatment with sialoglycoprotein isolated from the eggs of Carassius auratus (Ca-SGP) on these two types of osteoporosis were investigated in vivo. Results showed that Ca-SGP sig ...
DOI:: 10.1021/acs.jafc.5b06132
: https://doi.org/10.1021/acs.jafc.5b06132

48. Skeletal effects of growth hormone and insulin-like growth factor-I therapy

Author:: Richard C. Lindsey; Subburaman Mohan
Source:: Molecular and Cellular Endocrinology 2016 v.432 pp. 44-55
ISSN:: 0303-7207
Subject:: animal models; bone density; bone formation; humans; in vitro studies; insulin-like growth factor I; insulin-like growth factor binding proteins; ligands; osteoporosis; proteinases; receptors; somatotropin; therapeutics; transgenic animals
Abstract:: ... The growth hormone/insulin-like growth factor (GH/IGF) axis is critically important for the regulation of bone formation, and deficiencies in this system have been shown to contribute to the development of osteoporosis and other diseases of low bone mass. The GH/IGF axis is regulated by a complex set of hormonal and local factors which can act to regulate this system at the level of the ligands, r ...
DOI:: 10.1016/j.mce.2015.09.017
PubMed:: 26408965
PubMed Central:: PMC4808510
: https://doi.org/10.1016/j.mce.2015.09.017

49. TIEG1 enhances Osterix expression and mediates its induction by TGFβ and BMP2 in osteoblasts

Author:: Malayannan Subramaniam; Kevin S. Pitel; Sarah G. Withers; Hicham Drissi; John R. Hawse
Source:: Biochemical and biophysical research communications 2016 v.470 pp. 528-533
ISSN:: 0006-291X
Subject:: DNA-binding domains; bone density; bone formation; chromatin; cytokines; gene expression regulation; messenger RNA; mice; mineralization; osteoblasts; phenotype; precipitin tests; skeleton; transfection; transforming growth factor beta; zinc
Abstract:: ... Deletion of TIEG1/KLF10 in mice results in an osteopenic skeletal phenotype with significant decreases in both bone mineral density and content throughout the skeleton. Calvarial osteoblasts isolated from TIEG1 knockout (KO) mice display numerous changes in gene expression and exhibit significant delays in their mineralization rates relative to wild-type (WT) controls. Here, we demonstrate that lo ...
DOI:: 10.1016/j.bbrc.2016.01.112
PubMed:: 26801561
PubMed Central:: PMC4747784
: https://doi.org/10.1016/j.bbrc.2016.01.112

50. The effects of different levels of calcium supplementation on the bone mineral status of postpartum lactating Chinese women: a 12-month randomised, double-blinded, controlled trial

Author:: Zhe-Qing Zhang; Yu-Ming Chen; Ruo-Qin Wang; Zhen-Wu Huang; Xiao-Guang Yang; Yi-Xiang Su
Source:: British journal of nutrition 2016 v.115 no.1 pp. 24-31
ISSN:: 1475-2662
Subject:: Chinese people; bone density; breast feeding; calcium; dried milk; dual-energy X-ray absorptiometry; hips; lactating women; lactation; lumbar spine; vitamin D
Abstract:: ... Increasing dietary Ca intake may prevent the excessive mobilisation of bone mineral in nursing mothers. We aimed to investigate whether higher Ca intake could positively modulate the bone mineral changes in Chinese postpartum lactating women. The study was a 12-month randomised, double-blinded, parallel group trial conducted over 12 months. A total of 150 postpartum women were randomly selected to ...
DOI:: 10.1017/S0007114515003967
PubMed:: 26522081
: https://doi.org/10.1017/S0007114515003967

51. The in vivo effects of a fraction from Dioscorea spongiosa on glucocorticoid-induced osteoporosis

Author:: Na Han; Jinghua Xu; Feng Xu; Zhihui Liu; Jun Yin
Source:: Journal of ethnopharmacology 2016 v.185 pp. 53-59
ISSN:: 0378-8741
Subject:: Dioscorea; Oriental traditional medicine; alanine transaminase; biomechanics; blood serum; bone density; bone resorption; calcium; creatinine; dexamethasone; ethanol; hardness; histology; kidneys; metrology; models; muscles; osteoporosis; ovariectomy; rats; urine
Abstract:: ... In traditional Chinese medicines, osteoporosis was considered to be induced by the deficiency of kidney's function. The Rhizoma of Dioscorea spongiosa was one of the kidney tonifying and bone strengthening agent in the traditional usage and previous study had shown that its 90% ethanol fraction was effective on anti-osteoporosis using the ovariectomized (OVX) rats. However, for the secondary osteo ...
DOI:: 10.1016/j.jep.2016.03.033
: https://doi.org/10.1016/j.jep.2016.03.033

52. The systemic effects of sclerostin overexpression using ΦC31 integrase in mice

Author:: Dongdong Zhang; Bo Mi Park; Myengmo Kang; HeeJin Nam; Eun Jin Kim; ChuHyun Bae; Sung Kil Lim
Source:: Biochemical and biophysical research communications 2016 v.472 pp. 471-476
ISSN:: 0006-291X
Subject:: antibodies; blood flow; blood serum; bone density; bone formation; bone resorption; caudal vein; clinical trials; genes; hepatocytes; humans; liver; mice; micro-computed tomography; plasmids; risk; signal transduction; skeleton
Abstract:: ... Sclerostin, encoded by the Sost gene, is mainly produced by osteocytes in bone and antagonizes the Wnt/β-catenin signaling pathway, which is a requisite for bone formation. Currently, human anti-sclerostin antibodies are being tested in phase III clinical trials. In addition, serum sclerostin levels are reported to be associated with bone mineral density and fracture risk in normal individuals; ho ...
DOI:: 10.1016/j.bbrc.2016.01.178
: https://doi.org/10.1016/j.bbrc.2016.01.178

53. A 7-Year Longitudinal Trial of the Safety and Efficacy of a Vitamin/Mineral Enhanced Plant-Sourced Calcium Supplement

Author:: Gilbert R. Kaats; Harry G. Preuss; Sidney Stohs; Nicholas Perricone
Source:: Journal of the American College of Nutrition 2016 v.35 no.2 pp. 91-99
ISSN:: 1541-1087
Subject:: adverse effects; blood; blood lipids; bone density; calcium; databases; dual-energy X-ray absorptiometry; females; risk
Abstract:: ... Objectives: The objective of this study was to examine the safety and efficacy of a vitamin–mineral enhanced plant-sourced calcium AlgaeCal calcium (AC) in female consumers who had taken the supplement from 1 to 7 years. Methods: Consumers who had completed at least one dual-energy x-ray absorptiometry (DEXA) bone mineral density (BMD) scan (N = 172) and/or blood chemistry test (N = 30) and purcha ...
DOI:: 10.1080/07315724.2015.1090357
: https://doi.org/10.1080/07315724.2015.1090357

54. A Prospective, Placebo‐Controlled Pilot Evaluation of the Effect of Omeprazole on Serum Calcium, Magnesium, Cobalamin, Gastrin Concentrations, and Bone in Cats

Author:: E. Gould; C. Clements; A. Reed; L. Giori; J.M. Steiner; J.A. Lidbury; J.S. Suchodolski; M. Brand; T. Moyers; L. Emery; M.K. Tolbert
Source:: Journal of veterinary internal medicine 2016 v.30 no.3 pp. 779-786
ISSN:: 0891-6640
Subject:: adults; analysis of variance; blood serum; bone density; calcium; cats; electrolytes; gastrins; homeostasis; humans; hypersecretion; magnesium; monitoring; pH; placebos; proton pump inhibitors; vitamin B12
Abstract:: ... BACKGROUND: Chronic proton pump inhibitor administration has been associated with electrolyte and cobalamin deficiency, disrupted bone homeostasis, hypergastrinemia, and rebound acid hypersecretion in humans. It is unknown if this occurs in cats. OBJECTIVES: Prolonged oral omeprazole results in altered bone mineral density or content, serum calcium, magnesium, cobalamin, and gastrin concentrations ...
DOI:: 10.1111/jvim.13932
PubMed:: 27062346
PubMed Central:: PMC4913587
: https://doi.org/10.1111/jvim.13932

55. A prospective follow up of age related changes in the subchondral bone density of the talus of healthy Labrador Retrievers

Author:: W. Dingemanse; M. Müller-Gerbl; I. Jonkers; J. Vander Sloten; H. van Bree; I. Gielen
Source:: BMC veterinary research 2016 v.13 no.1 pp. 57
ISSN:: 1746-6148
Subject:: Labrador Retriever; bone density; computed tomography; prospective studies; skeleton; topography
Abstract:: ... BACKGROUND: During growth, the skeletal structures adapt to the increased loading conditions and mature to a fully-grown skeleton. Subchondral bone density reflects the effect of long-term joint loading and it is expected to change over time. The aim of this study was to describe the long-term changes in the density distribution of the subchondral bone of the talus of healthy Labrador Retrievers i ...
DOI:: 10.1186/s12917-017-0974-y
PubMed:: 28219379
PubMed Central:: PMC5319136
: https://doi.org/10.1186/s12917-017-0974-y

56. A randomized, controlled trial evaluating the efficacy of an online intervention targeting vitamin D intake, knowledge and status among young adults

Author:: Samantha Goodman; Barbara Morrongiello; Kelly Meckling
Source:: international journal of behavioral nutrition and physical activity 2016 v.13 no.1 pp. 116
ISSN:: 1479-5868
Subject:: analysis of variance; blood; bone density; cholecalciferol; education; food frequency questionnaires; food intake; gender; men; surveys; vitamin status; women; young adults; Ontario
Abstract:: ... BACKGROUND: Vitamin D plays a key role in bone health. Consuming adequate vitamin D during young adulthood is important due to the development of peak bone mass; however, many Canadian young adults do not meet vitamin D recommendations. This study aimed to improve knowledge, perceptions, dietary intake and blood concentrations of vitamin D among a sample of young adults. METHODS: Using a pre-post ...
DOI:: 10.1186/s12966-016-0443-1
PubMed:: 27836017
PubMed Central:: PMC5106840
: https://doi.org/10.1186/s12966-016-0443-1

57. Adiposity is associated with early reduction in bone mass in pediatric inflammatory bowel disease

Author:: Nithya Setty-Shah; Louise Maranda; Benjamin Udoka Nwosu
Source:: Nutrition 2016 v.32 no.7-8 pp. 761-766
ISSN:: 0899-9007
Subject:: Crohn disease; adiposity; adolescents; body mass index; bone density; children; colitis; femur; lumbar spine; obesity; therapeutics; vertebrae
Abstract:: ... The effect of adiposity on bone mass in the early phases of inflammatory bowel disease (IBD) in children and adolescents is unclear. The aim of this study was to determine the role of adiposity on bone mass in the first 3 y of diagnosis of IBD. The expected result is that increased adiposity will be associated with increased bone mass in both the controls and IBD subjects.Height-adjusted bone mine ...
DOI:: 10.1016/j.nut.2016.01.004
: https://doi.org/10.1016/j.nut.2016.01.004

58. Akt drives buffalo casein-derived novel peptide-mediated osteoblast differentiation

Author:: Srinu Reddi; Naveen Kumar; Rishika Vij; Sanusi Bello Mada; Suman Kapila; Rajeev Kapila
Source:: Journal of nutritional biochemistry 2016 v.38 pp. 134-144
ISSN:: 0955-2863
Subject:: alkaline phosphatase; bioactive compounds; bone density; bone resorption; buffaloes; casein; functional foods; health promotion; immunoblotting; immunocytochemistry; milk; osteoblasts; osteocalcin; peptides; postmenopause; women
Abstract:: ... Milk is a potential nutraceutical with wide range of bioactive compounds that are antioxidative, antimicrobial, antithrombotic, immunomodulatory, opioid and antihypertensive. Various intervention studies with milk reflect its stupendous role in elevating bone mineral density. Milk and milk products have shown a preventive effect in bone loss during pre- and postmenopausal women. Since, milk is pro ...
DOI:: 10.1016/j.jnutbio.2016.08.003
: https://doi.org/10.1016/j.jnutbio.2016.08.003

59. Anti-osteoporotic activity of harpagide by regulation of bone formation in osteoblast cell culture and ovariectomy-induced bone loss mouse models

Author:: Hwa-Jin Chung; Won Kyung Kim; Hyen Joo Park; Lan Cho; Me-riong Kim; Min Jeong Kim; Joon-Shik Shin; Jin Ho Lee; In-Hyuk Ha; Sang Kook Lee
Source:: Journal of ethnopharmacology 2016 v.179 pp. 66-75
ISSN:: 0378-8741
Subject:: Harpagophytum procumbens; alkaline phosphatase; animal models; bioactive compounds; biomarkers; blood serum; bone density; bone formation; bone marrow cells; bone resorption; cell culture; femur; glucosides; hydrolysis; mechanism of action; mice; oral administration; osteoarthritis; osteoblasts; osteocalcin; osteoclasts; ovariectomy; patients; traditional medicine
Abstract:: ... Harpagide, an iridoid glucoside, is a constituent of the root of Harpagophytum procumbens var. sublobatum (Engl.) Stapf, Devil's claw which has been used in patients with osteoarthritis (OA). In the present study, we investigated the anti-osteoporotic potential of harpagide and its underlying mechanism of action in in vitro cell culture and in vivo bone loss animal models.Harpagide was obtained fr ...
DOI:: 10.1016/j.jep.2015.12.025
: https://doi.org/10.1016/j.jep.2015.12.025

60. Anti-osteoporotic effects of Pueraria candollei var. mirifica on bone mineral density and histomorphometry in estrogen-deficient rats

Author:: Sarocha Suthon; Sukanya Jaroenporn; Narattaphol Charoenphandhu; Panan Suntornsaratoon; Suchinda Malaivijitnond
Source:: Natural medicines 2016 v.70 no.2 pp. 225-233
ISSN:: 1340-3443
Subject:: Pueraria; bone density; bone resorption; females; osteoblasts; osteoporosis; ovariectomy; patients; plant estrogens; postmenopause; rats; tibia; women
Abstract:: ... Although it has been clearly shown that Pueraria mirifica and its phytoestrogens can mimic estrogen in preventing bone loss, as osteoporosis is an asymptomatic disease, the therapeutic effects of P. mirifica should be acknowledged. In this study, 6-month-old female rats were ovariectomized, kept for 4 weeks to induce bone loss, divided into five groups, and treated with P. mirifica at doses of 0, ...
DOI:: 10.1007/s11418-016-0965-5
: https://doi.org/10.1007/s11418-016-0965-5

61. Association between dietary iron intake and bone mineral density: A cross‐sectional study in Chinese population

Author:: Yilin Xiong; Jie Wei; Chao Zeng; Tuo Yang; Hui Li; Zhenhan Deng; Yi Zhang; Xiang Ding; Ye Yang; Guanghua Lei
Source:: Nutrition & dietetics 2016 v.73 no.5 pp. 433-440
ISSN:: 1446-6368
Subject:: alcohol drinking; body mass index; bone density; calcium; cross-sectional studies; diabetes; energy intake; exercise; females; food frequency questionnaires; food intake; hypertension; iron; logit analysis; males; models; osteoporosis; phalanges; postmenopause; smoking (habit); waist circumference
Abstract:: ... AIM: The incidence of osteoporosis is rising continuously along with the ageing process in the Chinese population. Iron is an important trace element for bone growth, development and maintenance. However, the association of dietary iron with bone mineral density has not been widely investigated. The present study examined the cross‐sectional association between dietary iron intake and phalangeal o ...
DOI:: 10.1111/1747-0080.12255
: https://doi.org/10.1111/1747-0080.12255

62. Biological Silicon Stimulates Collagen Type 1 and Osteocalcin Synthesis in Human Osteoblast-Like Cells Through the BMP-2/Smad/RUNX2 Signaling Pathway

Author:: Meng Dong; Guangjun Jiao; Haichun Liu; Wenliang Wu; Shangzhi Li; Qingshi Wang; Daxia Xu; Xiaofeng Li; Huan Liu; Yunzhen Chen
Source:: Biological trace element research 2016 v.173 no.2 pp. 306-315
ISSN:: 0163-4984
Subject:: Western blotting; animal models; bone density; bone formation; collagen; diet; fluorescent antibody technique; humans; mechanism of action; mineralization; osteoblasts; osteocalcin; osteosarcoma; rats; signal transduction; silicon; stem cells; transcription factors
Abstract:: ... Silicon is essential for bone formation. A low-silicon diet leads to bone defects, and numerous animal models have demonstrated that silicon supplementation increases bone mineral density (BMD) and reduces bone fragility. However, the exact mechanism of this action has not been characterized. In this study, we aimed to determine the role of biological silicon in the induction of osteoblast differe ...
DOI:: 10.1007/s12011-016-0686-3
: https://doi.org/10.1007/s12011-016-0686-3

63. CT Imaging Biomarkers of Bone Damage Induced by Environmental Level of Cadmium Exposure in Male Rats

Author:: Lirong Tang; Xiao Chen; Yizhong Bao; Weihong Xu; Yuandong Lv; Zhongqiu Wang; Xiaolin Wen
Source:: Biological trace element research 2016 v.170 no.1 pp. 146-151
ISSN:: 0163-4984
Subject:: biomarkers; bone density; bone resorption; cadmium; computer software; drinking water; image analysis; males; micro-computed tomography; osteoporosis; rats; tibia
Abstract:: ... Cadmium (Cd) can induce bone loss and osteoporosis. Histologic methods have shown that Cd can induce microarchitecture change of the trabecular bone. The aim of this study is to evaluate the imaging biomarkers of osteoporosis induced by Cd using micro-computed tomography (micro-CT). Twenty-four male Sprague-Dawley rats were randomly divided into four groups that were exposed to Cd via drinking wat ...
DOI:: 10.1007/s12011-015-0447-8
: https://doi.org/10.1007/s12011-015-0447-8

64. Calcium plus vitamin D supplementation during pregnancy interacts with polymorphisms in the promoter region of the VDR gene to affect postpartum bone mass of Brazilian adolescent mothers: A randomized controlled trial

Author:: Paula Normando; Maria Eduarda L. Diogenes; Pedro H. Cabello; Giselda M. Cabello; Carmen M. Donangelo; Flávia F. Bezerra
Source:: Nutrition 2016 v.32 no.10 pp. 1068-1074
ISSN:: 0899-9007
Subject:: adolescent mothers; blood serum; bone density; bone resorption; calcium; cholecalciferol; femur; genes; genotype; genotyping; hips; lumbar spine; mineral content; parathyroid hormone; parturition; placebos; pregnancy; promoter regions; quantitative polymerase chain reaction; randomized clinical trials; vitamin-mineral supplements; Brazil
Abstract:: ... We investigated whether calcium plus vitamin D supplementation interacts with polymorphisms in the VDR gene promoter region to affect changes on maternal bone mass from 5 to 20 wk postpartum in Brazilian adolescent mothers.Pregnant adolescents (14–19 y) randomly received calcium plus cholecalciferol (600 mg/d + 200 IU/d, n = 30) or placebo (n = 26) from 26 wk of pregnancy until parturition. Bone m ...
DOI:: 10.1016/j.nut.2016.03.002
: https://doi.org/10.1016/j.nut.2016.03.002

65. Cdx-2 polymorphism in Vitamin D Receptor gene was associated with serum 25-hydroxyvitamin D levels, bone mineral density and fracture in middle-aged and elderly Chinese women

Author:: Yan Ling; Huandong Lin; Qiqige Aleteng; Hui Ma; Baishen Pan; Jian Gao; Xin Gao
Source:: Molecular and Cellular Endocrinology 2016 v.427 pp. 155-161
ISSN:: 0303-7207
Subject:: Chinese people; blood serum; body mass index; bone density; cross-sectional studies; elderly; femur; gender differences; genes; genotype; glomerular filtration rate; hips; lumbar spine; men; menopause; middle-aged adults; osteoporosis; promoter regions; risk; vitamin D; women
Abstract:: ... The aim of the current study was to examine the relationship between Cdx-2 polymorphism in the promoter region of the VDR gene and serum 25-hydroxyvitamin D (25(OH)D) levels, bone mineral density (BMD) and fracture in Chinese population. This was a cross-sectional study, which included 738 individuals (428 women and 310 men) aged 45 years or older. In women, the association of Cdx-2 polymorphism w ...
DOI:: 10.1016/j.mce.2016.03.014
: https://doi.org/10.1016/j.mce.2016.03.014

66. Chronic lead poisoning magnifies bone detrimental effects in an ovariectomized rat model of postmenopausal osteoporosis

Author:: Ching Ming Lee; Antonela Romina Terrizzi; Clarisa Bozzini; Adriana Emilce Piñeiro; María Inés Conti; María Pilar Martínez
Source:: Experimental and toxicologic pathology 2016 v.68 no.1 pp. 47-53
ISSN:: 0940-2993
Subject:: acetates; animal models; biomechanics; bone density; bone resorption; deformation; drinking water; elderly; females; femur; lead; lead poisoning; osteoporosis; ovariectomy; postmenopause; rats; risk; women
Abstract:: ... Lead (Pb) is a persistent environmental contaminant that is mainly stored in bones being an important source of endogenous lead exposure during periods of increased bone resorption as occurs in menopause. As no evidence exists of which bone biomechanical properties are impaired in those elderly women who had been exposed to Pb during their lifetime, the aim of the present study is to discern wheth ...
DOI:: 10.1016/j.etp.2015.09.007
: https://doi.org/10.1016/j.etp.2015.09.007

67. Collected literature on isoflavones and chronic diseases

Author:: Katie A. Miller; Farrell Frankel; Hitomi Takahashr; Nicole Vance; Celia Stiegerwald; Sari Edelstein; Fatih Yildiz
Source:: Cogent food & agriculture 2016 v.2 no.1 pp. 1135861
ISSN:: 2331-1932
Subject:: agriculture; angiogenesis; bioavailability; bone density; breast neoplasms; carcinogenesis; cardiovascular diseases; daidzein; genistein; glioma; glycitein; postmenopause; prostatic neoplasms; risk reduction; therapeutics
Abstract:: ... Isoflavones are organic compounds, which have been linked to the health benefits and prevention of many diseases. Common isoflavones are genistein, daidzein, and glycitein. Genistein has been researched in regard to its effect on the reduction of menopausal symptoms and reduction of cardiovascular risk factors in osteopenic, post-menopausal women. Research on daidzein focuses on bone mineral densi ...
DOI:: 10.1080/23311932.2015.1135861
: https://doi.org/10.1080/23311932.2015.1135861

68. Comparison of black, green and rooibos tea on osteoblast activity

Author:: L. A. Nash; W. E. Ward
Source:: Food & function 2016 v.7 no.2 pp. 1166-1175
ISSN:: 2042-650X
Subject:: Aspalathus linearis; alkaline phosphatase; antioxidant activity; beverages; bone density; cytotoxicity; enzyme activity; gallic acid; in vivo studies; interleukin-6; mineral content; osteoblasts; osteopontin; polyphenols; postmenopause; tea; tumor necrosis factor-alpha; women
Abstract:: ... Globally, tea is the second most consumed beverage after water. Habitual tea intake has been associated with higher bone mineral density, particularly in postmenopausal women. This association may be due to its polyphenols and resulting protective antioxidant effects. While in vivo studies have shown improved bone outcomes with a consumption of individual purified tea polyphenols, it is unclear if ...
DOI:: 10.1039/c5fo01222h
: https://doi.org/10.1039/c5fo01222h

69. Comparisons among radiography, ultrasonography and computed tomography for ex vivo characterization of stifle osteoarthritis in the horse

Author:: Julie De Lasalle; Kate Alexander; Julien Olive; Sheila Laverty
Source:: Veterinary radiology & ultrasound 2016 v.57 no.5 pp. 489-501
ISSN:: 1058-8183
Subject:: bone density; bone resorption; computed tomography; horses; image analysis; osteoarthritis; prognosis; radiography; sclerosis; stifle; ultrasonics; ultrasonography
Abstract:: ... A better understanding of imaging characteristics of equine stifle osteoarthritis (OA) may allow earlier detection and improve prognosis. Objectives of this ex vivo, prospective, methods comparison study were to (1) describe the location and severity of naturally acquired OA lesions in the equine stifle using ultrasound (US), radiography (XR), computed tomography (CT), and macroscopic evaluation ( ...
DOI:: 10.1111/vru.12370
: https://doi.org/10.1111/vru.12370

70. Consumption of onion juice modulates oxidative stress and attenuates the risk of bone disorders in middle-aged and post-menopausal healthy subjects

Author:: Yat-Yin Law; Hui-Fang Chiu; Hui-Hsin Lee; You-Cheng Shen; Kamesh Venkatakrishnan; Chin-Kun Wang
Source:: Food & function 2016 v.7 no.2 pp. 902-912
ISSN:: 2042-650X
Subject:: alkaline phosphatase; anthropometric measurements; antioxidant activity; antioxidants; blood sampling; bone density; bone resorption; cell lines; free radicals; humans; in vitro studies; in vivo studies; onions; osteoclasts; osteoporosis; oxidative stress; placebos; postmenopause; vegetable juices; women
Abstract:: ... Osteoporosis is a chronic inflammatory condition that is characterized by the loss of bone mineral density (BMD). The current study was undertaken to evaluate the impact of onion juice intake on the bone mineral density (BMD) and bone loss in corroboration with antioxidant effects in human (in vivo) as well as inhibitory effects on the differentiation of osteoclasts in the cell line (in vitro). Fo ...
DOI:: 10.1039/c5fo01251a
: https://doi.org/10.1039/c5fo01251a

71. Coordinate regulatory osteogenesis effects of icariin, timosaponin B II and ferulic acid from traditional Chinese medicine formulas on UMR-106 osteoblastic cells and osteoblasts in neonatal rat calvaria cultures

Author:: Mei Li; Nai-Dan Zhang; Yin Wang; Ting Han; Yi-Ping Jiang; Khalid Rahman; Lu-Ping Qin; Hai-Liang Xin; Qiao-Yan Zhang
Source:: Journal of ethnopharmacology 2016 v.185 pp. 120-131
ISSN:: 0378-8741
Subject:: Anemarrhena asphodeloides; Angelica sinensis; Epimedium brevicornu; Liliaceae; Oriental traditional medicine; acid phosphatase; adverse effects; alkaline phosphatase; blood chemistry; bone density; bone formation; crosslinking; ferulic acid; icariin; immunohistochemistry; ingredients; leaves; mice; mineral content; mineralization; models; osteoblasts; osteoporosis; ovariectomy; proteins; rhizomes; signal transduction; skull
Abstract:: ... Icariin (I), ferulic acid (F) and timosaponin B II (T) derived respectively from the leaf of Epimedium brevicornu Maxim (EBM, Berberidaceae), rhizome of Anemarrhena asphodeloides Bunge (AAB, Liliaceae) and root of Angelica sinensis (Oliv.) Diels (ASD, Umbelliferae) are included in several traditional Chinese medicine (TCM) formulas for the treatment of osteoporosis. In addition, the medicinal mate ...
DOI:: 10.1016/j.jep.2016.03.023
: https://doi.org/10.1016/j.jep.2016.03.023

72. Correlations of VDR and VDBP genetic polymorphisms with susceptibility to adolescent idiopathic scoliosis and efficacy of brace treatment

Author:: Yu Wang; Zhi-Qiang Cui; Tian-Bao Luo; Long Liu
Source:: Genomics 2016 v.108 no.5-6 pp. 194-200
ISSN:: 0888-7543
Subject:: adolescents; alleles; bone density; dual-energy X-ray absorptiometry; femur; genotype; lumbar spine; patients; polymerase chain reaction; restriction fragment length polymorphism; scoliosis
Abstract:: ... This paper aimed to elucidate the correlations of VDR and VDBP polymorphisms with susceptibility to adolescent idiopathic scoliosis (AIS) and efficacy of brace treatment.AIS patients and healthy controls were enrolled. Lumbar spine bone mineral density (LSBMD) and femoral neck bone mineral density (FNBMD) were detected by dual energy X-ray absorptiometry. VDR and VDBP polymorphisms were detected b ...
DOI:: 10.1016/j.ygeno.2016.11.004
: https://doi.org/10.1016/j.ygeno.2016.11.004

73. Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

Author:: Anil Bhatta; Rajnikumar Sangani; Ravindra Kolhe; Haroldo A. Toque; Michael Cain; Abby Wong; Nicole Howie; Rahul Shinde; Mohammed Elsalanty; Lin Yao; Norman Chutkan; Monty Hunter; Ruth B. Caldwell; Carlos Isales; R. William Caldwell; Sadanand Fulzele
Source:: Molecular and Cellular Endocrinology 2016 v.422 pp. 211-220
ISSN:: 0303-7207
Subject:: animal disease models; arginase; arginine; bone density; bone marrow; bone metabolism; diabetic complications; diabetic diet; glucose; high fat diet; lipid content; metabolism; nitric oxide; obesity; osteoporosis; streptozotocin; stromal cells; urea
Abstract:: ... A balanced diet is crucial for healthy development and prevention of musculoskeletal related diseases. Diets high in fat content are known to cause obesity, diabetes and a number of other disease states. Our group and others have previously reported that activity of the urea cycle enzyme arginase is involved in diabetes-induced dysregulation of vascular function due to decreases in nitric oxide fo ...
DOI:: 10.1016/j.mce.2015.12.005
PubMed:: 26704078
PubMed Central:: PMC4824063
: https://doi.org/10.1016/j.mce.2015.12.005

74. Determinants of microstructural, dimensional and bone mineral changes postpartum in Swedish women

Author:: Petra Brembeck; Anna Winkvist; Claes Ohlsson; Mattias Lorentzon; Hanna Augustin
Source:: British journal of nutrition 2016 v.116 no.10 pp. 1736-1744
ISSN:: 1475-2662
Subject:: blood sampling; blood serum; body mass index; body weight; bone density; calcium; computed tomography; contraceptives; dual-energy X-ray absorptiometry; estrogens; food records; lactation; liquid chromatography; lumbar spine; microstructure; physical activity; tibia; women
Abstract:: ... During lactation, areal (a) and volumetric (v) bone mineral density (BMD) are known to temporarily decrease. Factors that affect skeletal changes postpartum are not fully elucidated. The aim was to study determinants of the previously observed changes in aBMD at lumbar spine, and cortical vBMD, microstructure and dimensions at ultra-distal tibia postpartum. Women (25–40 years) were studied longitu ...
DOI:: 10.1017/S0007114516003998
PubMed:: 27876110
: https://doi.org/10.1017/S0007114516003998

75. Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice

Author:: Mohammad Shahnazari; Russell T. Turner; Urszula T. Iwaniec; Thomas J. Wronski; Min Li; Mario G. Ferruzzi; Robert A. Nissenson; Bernard P. Halloran
Source:: Journal of nutritional biochemistry 2016 v.34 pp. 73-82
ISSN:: 0955-2863
Subject:: blood serum; bone density; bone formation; bone resorption; diet; immune system; interleukins; males; mice; osteoblasts; osteoclasts; polyphenols; prunes; resorption; tumor necrosis factors; young adults
Abstract:: ... Nutrition is an important determinant of bone health and attainment of peak bone mass. Diets containing dried plum (DP) have been shown to increase bone volume and strength. These effects may be linked to the immune system and DP-specific polyphenols. To better understand these relationships, we studied DP in skeletally mature (6-month-old) and growing (1- and 2-month-old) C57Bl/6 male mice. In ad ...
DOI:: 10.1016/j.jnutbio.2016.04.007
: https://doi.org/10.1016/j.jnutbio.2016.04.007

76. Dietary licorice root supplementation reduces diet‐induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland

Author:: Zeynep Madak‐Erdogan; Ping Gong; Yiru Chen Zhao; Liwen Xu; Kinga U. Wrobel; James A. Hartman; Michelle Wang; Anthony Cam; Urszula T. Iwaniec; Russell T. Turner; Nathan C. Twaddle; Daniel R. Doerge; Ikhlas A. Khan; John A. Katzenellenbogen; Benita S. Katzenellenbogen; William G. Helferich
Source:: Molecular nutrition & food research 2016 v.60 no.2 pp. 369-380
ISSN:: 1613-4125
Subject:: blood; body weight changes; bone density; dietary supplements; dual-energy X-ray absorptiometry; fatty liver; food consumption; gene expression; genes; high fat diet; licorice; liver; magnetic resonance imaging; mammary glands; menopause; metabolism; mice; models; obesity; ovariectomy; phenotype; subcutaneous fat; uterus; weight gain
Abstract:: ... SCOPE: We studied the impact of dietary supplementation with licorice root components on diet‐induced obesity, fat accumulation, and hepatic steatosis in ovariectomized C57BL/6 mice as a menopause model. MATERIALS AND METHODS: We evaluated the molecular and physiological effects of dietary licorice root administered to ovariectomized C57BL/6 mice as root powder (LRP), extracts (LRE), or isolated i ...
DOI:: 10.1002/mnfr.201500445
PubMed:: 26555669
PubMed Central:: PMC4738101
: https://doi.org/10.1002/mnfr.201500445

77. Diets High in Fiber and Vegetable Protein Are Associated with Low Lumbar Bone Mineral Density in Young Athletes with Oligoamenorrhea

Author:: Elizabeth Barron; Natalia Cano Sokoloff; Giovana D.N. Maffazioli; Kathryn E. Ackerman; Ryan Woolley; Tara M. Holmes; Ellen J. Anderson; Madhusmita Misra
Source:: Journal of the Academy of Nutrition and Dietetics 2016 v.116 no.3 pp. 481-489
ISSN:: 2212-2672
Subject:: athletes; blood serum; body composition; body weight; bone density; calcium; cross-sectional studies; daidzein; dietary fiber; dietary recommendations; dual-energy X-ray absorptiometry; energy; food intake; food records; genistein; lumbar spine; multivariate analysis; nutrients; phytic acid; saturated fatty acids; vegetable protein; vitamin D
Abstract:: ... Associations of bone mineral density (BMD) with specific food components, including dietary fiber and isoflavones (that have a negative association with serum estrogen), are unclear and need to be determined, particularly in populations more likely to consume large amounts of these nutrients (such as young athletes).To determine dietary intake of specific food components in athletes with oligoamen ...
DOI:: 10.1016/j.jand.2015.10.022
PubMed:: 26686817
PubMed Central:: PMC4769909
: https://doi.org/10.1016/j.jand.2015.10.022

78. Dose‐dependent effects of isoflavone exposure during early lifetime on development and androgen sensitivity in male Wistar rats

Author:: Dennis R. Müller; Fabian Basso; Anne Kurrat; Sebastian T. Soukup; Anja Niehoff; Sabine E. Kulling; Patrick Diel
Source:: Molecular nutrition & food research 2016 v.60 no.2 pp. 325-336
ISSN:: 1613-4125
Subject:: Asians; adolescence; blood serum; body weight; bone density; castration; dose response; embryogenesis; fatty-acid synthase; food intake; homeostasis; isoflavones; lipid metabolism; males; men; propionic acid; rats; seminal vesicles; testosterone; triacylglycerols; young adults
Abstract:: ... SCOPE: The aim of our study was to investigate dose‐dependent effects of isoflavone (ISO) exposure during adolescence on the androgen sensitivity of various physiological end points in male Wistar rats. METHODS AND RESULTS: During embryogenesis and adolescence, rats were exposed to an ISO‐depleted diet (IDD) or one of two diets enriched with different concentrations of a soy‐based ISO extract caus ...
DOI:: 10.1002/mnfr.201500559
: https://doi.org/10.1002/mnfr.201500559

79. ESPEN-ESPGHAN-ECFS guidelines on nutrition care for infants, children, and adults with cystic fibrosis

Author:: Dominique Turck; Christian P. Braegger; Carla Colombo; Dimitri Declercq; Alison Morton; Ruzha Pancheva; Eddy Robberecht; Martin Stern; Birgitta Strandvik; Sue Wolfe; Stephane M. Schneider; Michael Wilschanski
Source:: Clinical nutrition 2016 v.35 no.3 pp. 557-577
ISSN:: 0261-5614
Subject:: adults; appetite; bone density; breast feeding; children; comorbidity; cystic fibrosis; dietary mineral supplements; education; energy intake; essential fatty acids; excretion; guidelines; infants; inflammation; iron; lung function; malnutrition; nutrient deficiencies; nutritional status; patients; probiotics; sodium; somatotropin; surveys; tube feeding
Abstract:: ... Malnutrition is both a frequent feature and a comorbidity of cystic fibrosis (CF), with nutritional status strongly associated with pulmonary function and survival. Nutritional management is therefore standard of care in CF patients. ESPEN, ESPGHAN and ECFS recommended guidelines to cover nutritional management of patients with CF.The guidelines were developed by an international multidisciplinary ...
DOI:: 10.1016/j.clnu.2016.03.004
: https://doi.org/10.1016/j.clnu.2016.03.004

80. Echinocystic acid inhibits RANKL-induced osteoclastogenesis by regulating NF-κB and ERK signaling pathways

Author:: Jian-hui Yang; Qiong Wu; Jian-guo Lv; Hui-Yong Nie
Source:: Biochemical and biophysical research communications 2016 pp. -
ISSN:: 0006-291X
Subject:: Gleditsia sinensis; transcription factor NF-kappa B; osteoclasts; fruits; macrophages; signal transduction; ovariectomy; bone density; bone marrow; triterpenoids; osteoporosis; rats; phosphorylation; mitogen-activated protein kinase
Abstract:: ... Receptor activator of nuclear factor-κB ligand (RANKL) is a key factor in the differentiation and activation of osteoclasts. Echinocystic acid (EA), a pentacyclic triterpene isolated from the fruits of Gleditsia sinensis Lam, was reported to prevent reduction of bone mass and strength and improve the cancellous bone structure and biochemical properties in ovariectomy rats. However, the molecular m ...
DOI:: 10.1016/j.bbrc.2016.06.118
: https://doi.org/10.1016/j.bbrc.2016.06.118

81. Effect of Silicon Supplementation on Bone Status in Ovariectomized Rats Under Calcium-Replete Condition

Author:: So Young Bu; Mi-Hyun Kim; Mi-Kyeong Choi
Source:: Biological trace element research 2016 v.171 no.1 pp. 138-144
ISSN:: 0163-4984
Subject:: biomarkers; bone density; bone resorption; calcium; cell culture; diet; femur; gene expression; gene expression regulation; interleukin-6; messenger RNA; mineralization; osteocalcin; ovariectomy; rats; reactive oxygen species; silicon; tibia; tumor necrosis factor-alpha; vertebrae
Abstract:: ... Previous studies have suggested that silicon (Si) had positive effects on bone, but such benefits from Si may be dependent on calcium status. Also, several biochemical roles of Si in osteoblastic mineralization, the regulation of gene expression related to bone matrix synthesis, and the decrease in reactive oxygen species and pro-inflammatory mediators were reported, but these effects were mostly ...
DOI:: 10.1007/s12011-015-0506-1
: https://doi.org/10.1007/s12011-015-0506-1

82. Effect of Sodium Fluoride on Bone Biomechanical and Histomorphometric Parameters and on Insulin Signaling and Insulin Sensitivity in Ovariectomized Rats

Author:: Rita de Cássia Alves Nunes; Fernando Yamamoto Chiba; Amanda Gomes Pereira; Renato Felipe Pereira; Maria Sara de Lima Coutinho Mattera; Edilson Ervolino; Mário Jefferson Quirino Louzada; Marília Afonso Rabelo Buzalaf; Cristina Antoniali Silva; Doris Hissako Sumida
Source:: Biological trace element research 2016 v.173 no.1 pp. 144-153
ISSN:: 0163-4984
Subject:: biomechanics; blood glucose; body weight changes; bone density; calcium; drinking water; glucose; high density lipoprotein cholesterol; homeostasis; insulin; insulin resistance; interleukin-6; low density lipoprotein cholesterol; mineral content; osteocalcin; osteoporosis; ovariectomy; phosphorylation; rats; risk; signal transducing adaptor proteins; sodium fluoride; tibia; triacylglycerols; tumor necrosis factor-alpha; tyrosine; white adipose tissue
Abstract:: ... Osteoporosis is a systemic disease characterized by bone degradation and decreased bone mass that promotes increased bone fragility and eventual fracture risk. Studies have investigated the use of sodium fluoride (NaF) for the treatment of osteoporosis. However, fluoride can alter glucose homeostasis. The aim of this study was to evaluate the effects of NaF intake (50 mg/L) from water on the follo ...
DOI:: 10.1007/s12011-016-0642-2
: https://doi.org/10.1007/s12011-016-0642-2

83. Effect of a mixture of GOS/FOS® on calcium absorption and retention during recovery from protein malnutrition: experimental model in growing rats

Author:: Gabriel Bryk; Magalí Zeni Coronel; Carlos Lugones; Patricia Mandalunis; María Esther Rio; Ariel Felix Gualtieri; María Luz Pita Martín de Portela; Susana Noemí Zeni
Source:: European journal of nutrition 2016 v.55 no.8 pp. 2445-2458
ISSN:: 1436-6207
Subject:: absorption; beta-glucosidase; beta-glucuronidase; body weight; bone density; bone mineralization; calcium; cecum; colon; compensatory growth; femur; growth plate; kwashiorkor; low protein diet; magnesium; mineral content; minerals; models; modulus of elasticity; pH; prebiotics; rats; refeeding; skeletal development; skeleton; tibia; tryptophan 2,3-dioxygenase; urease; weaning
Abstract:: ... INTRODUCTION: During growth, protein deprivation impairs epiphyseal growth plate (EGP) height, bone volume (BV) and endochondral ossification. During catch-up growth, Ca availability becomes essential to ensure the extra amount needed to achieve optimal peak bone mass and strength. GOS and FOS improve mineral absorption in the colon. PURPOSE: The effect of a mixture of GOS/FOS® 9:1 added to a 0.5 ...
DOI:: 10.1007/s00394-015-1052-5
: https://doi.org/10.1007/s00394-015-1052-5

84. Effect of chronic undernutrition on body mass and mechanical bone quality under normoxic and altitude hypoxic conditions

Author:: Christian Lezon; Clarisa Bozzini; Alan Agûero Romero; Patricia Pinto; Graciela Champin; Rosa M. Alippi; Patricia Boyer; Carlos E. Bozzini
Source:: British journal of nutrition 2016 v.115 no.9 pp. 1687-1695
ISSN:: 1475-2662
Subject:: air; altitude; anaerobic conditions; appetite; biomechanics; bone density; bone mineralization; compensatory growth; equations; femur; food intake; geometry; hypoxia; males; malnutrition; mechanical properties; mineralization; modulus of elasticity; rats
Abstract:: ... Both undernutrition and hypoxia exert a negative influence on both growth pattern and bone mechanical properties in developing rats. The present study explored the effects of chronic food restriction on both variables in growing rats exposed to simulated high-altitude hypoxia. Male rats (n 80) aged 28 d were divided into normoxic (Nx) and hypoxic (Hx) groups. Hx rats were exposed to hypobaric air ...
DOI:: 10.1017/S000711451600060X
PubMed:: 26961128
: https://doi.org/10.1017/S000711451600060X

85. Effect of glucocorticoid withdrawal on glucocorticoid inducing bone impairment

Author:: Gengyang Shen; Hui Ren; Ting Qiu; De Liang; Qiushi Wei; Jingjing Tang; Zhida Zhang; Zhensong Yao; Wenhua Zhao; Xiaobing Jiang
Source:: Biochemical and biophysical research communications 2016 pp. -
ISSN:: 0006-291X
Subject:: absorption; biomechanics; blood serum; bone density; bone strength; dexamethasone; dual-energy X-ray absorptiometry; energy; females; osteoporosis; rats; therapeutics; vertebrae
Abstract:: ... Glucocorticoid (GC) withdrawal after a short-term use was common in clinical practice like immediate post-transplant period. However, previous studies without setting age-control group failed to determine whether the BMD recovery was sufficient and whether it is necessary to accept anti-osteoporosis therapy after GC withdrawal. The aim of this study was to investigate the effect of GC withdrawal o ...
DOI:: 10.1016/j.bbrc.2016.07.036
: https://doi.org/10.1016/j.bbrc.2016.07.036

86. Effects of Artemisia princeps supplementation on bone metabolism in ovariectomized rats

Author:: H.-J. Cho; J.-W. Kim; S.-Y. Ju; Yoo-Kyoung Park
Source:: journal of nutrition, health & aging 2016 v.20 no.5 pp. 533-539
ISSN:: 1279-7707
Subject:: Artemisia indica var. maximowiczii; antioxidant activity; blood serum; bone density; bone resorption; calcium; chromium; excretion; females; osteoclasts; osteoporosis; ovariectomy; postmenopause; rats
Abstract:: ... The aim of this study was to investigate the effects of Artemisia princeps (AP) extract on bone metabolism and its potential role in the prevention of osteoporosis in ovariectomized rats. Twenty-six female Sprague-Dawley rats were divided into five groups and treated as follows: sham-operated control group (SHAM); ovariectomized control group (OVX), ovariectomized group treated by gavage with 10 m ...
DOI:: 10.1007/s12603-015-0607-8
: https://doi.org/10.1007/s12603-015-0607-8

87. Effects of Trigonelline, an Alkaloid Present in Coffee, on Diabetes-Induced Disorders in the Rat Skeletal System

Author:: Joanna Folwarczna; Aleksandra Janas; Maria Pytlik; Urszula Cegieła; Leszek Śliwiński; Zora Krivošíková; Kornélia Štefíková; Martin Gajdoš
Source:: Nutrients 2016 v.8 no.3 pp. -
ISSN:: 2072-6643
Subject:: animal disease models; blood glucose; blood serum; bone density; bone fractures; bone mineralization; bone strength; diabetes; females; glycemic effect; laboratory animals; mechanical properties; nicotinamide; rats; streptozotocin; trigonelline
Abstract:: ... Diabetes increases bone fracture risk. Trigonelline, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. The aim of the study was to investigate the effects of trigonelline on experimental diabetes-induced disorders in the rat skeletal system. Effects of trigonelline (50 mg/kg p.o. daily for four weeks) were investigated in three-month-old female Wistar ...
DOI:: 10.3390/nu8030133
PubMed:: 26950142
PubMed Central:: PMC4808862
: https://doi.org/10.3390/nu8030133

88. Effects of diet containing flaxseed flour (Linum usitatissimum) on body adiposity and bone health in young male rats

Author:: Carlos Alberto Soares da Costa; Paula Cristina Alves da Silva; Danielle Cavalcante Ribeiro; Aline D'Avila Pereira; Aline de Sousa dos Santos; Maíra Duque Coutinho de Abreu; Letícia Rozeno Pessoa; Bianca Ferolla da Camara Boueri; Carolina Ribeiro Pessanha; Celly Cristina Alves do Nascimento-Saba; Eduardo Moreira da Silva; Gilson Teles Boaventura
Source:: Food & function 2016 v.7 no.2 pp. 698-703
ISSN:: 2042-650X
Subject:: Linum usitatissimum; X-ray absorption spectroscopy; adipocytes; adiposity; alpha-linolenic acid; animal models; blood serum; bone density; bone health; dual-energy X-ray absorptiometry; experimental diets; femur; flour; food intake; functional properties; laboratory animals; lactation; linseed; males; obesity; pups; rats; vertebrae
Abstract:: ... Flaxseed flour has been described as an excellent alpha-linolenic acid source. This study was designed to evaluate the effects of flaxseed flour on body adiposity and bone health in rats fed a flaxseed flour diet during lactation until 90 days. At birth, male Wistar rats were randomly assigned to control (C) and experimental (FF) groups, whose dams were treated with a control or flaxseed flour die ...
DOI:: 10.1039/c5fo01598g
: https://doi.org/10.1039/c5fo01598g

89. Effects of dioxin-related compounds on bone mineral density in patients affected by the Yusho incident

Author:: Jun-ichi Fukushi; Shoji Tokunaga; Yasuharu Nakashima; Goro Motomura; Chikage Mitoma; Hiroshi Uchi; Masutaka Furue; Yukihide Iwamoto
Source:: Chemosphere 2016 v.145 pp. 25-33
ISSN:: 0045-6535
Subject:: adverse effects; blood serum; body mass index; bone density; bone metabolism; dual-energy X-ray absorptiometry; gas chromatography; humans; mass spectrometry; men; patients; polychlorinated biphenyls; polychlorinated dibenzofurans; rice oil; women; Japan
Abstract:: ... Exposure to dioxin-related compounds results in many adverse health effects. Several studies have examined the effects of dioxin-related compounds on human bone metabolism with inconsistent results. In Japan in 1968, accidental human exposure to rice oil contaminated with dioxin-related compounds led to the development of Yusho oil disease. The aim of this study was to determine whether exposure t ...
DOI:: 10.1016/j.chemosphere.2015.11.091
: https://doi.org/10.1016/j.chemosphere.2015.11.091

90. Effects of stock density on the laying performance, blood parameter, corticosterone, litter quality, gas emission and bone mineral density of laying hens in floor pens

Author:: H.K. Kang; S.B. Park; S.H. Kim; C.H. Kim
Source:: Poultry science 2016 v.95 no.12 pp. 2764-2770
ISSN:: 0032-5791
Subject:: blood chemistry; blood serum; bone density; carbon dioxide; corticosterone; diet; egg masses; egg production; egg quality; egg shell; feed intake; heterophils; stocking rate
Abstract:: ... The effects of stocking density on the performance, egg quality, leukocyte concentration, blood biochemistry, corticosterone levels, bone mineral density, and noxious gas emission of laying hens were investigated. Eight hundred 34-week-old Hy-Line Brown laying hens (Gallus gallus domesticus) were randomly assigned to one of 4 treatments, each of which was replicated 4 times. Four stocking densitie ...
DOI:: 10.3382/ps/pew264
: https://doi.org/10.3382/ps/pew264

91. Effects of yuja peel extract and its flavanones on osteopenia in ovariectomized rats and osteoblast differentiation

Author:: Eun Joo Jeon; Da‐Hye Lee; Yang‐Ji Kim; Jiyun Ahn; Min Jung Kim; Jin‐Taek Hwang; Jinyoung Hur; Mina Kim; Young‐Jin Jang; Tae‐Youl Ha; Dong‐Hyun Seo; Jong Suk Lee; Mi Jeong Sung; Chang Hwa Jung
Source:: Molecular nutrition & food research 2016 v.60 no.12 pp. 2587-2601
ISSN:: 1613-4125
Subject:: Citrus junos; alkaline phosphatase; body weight; bone density; ethanol; femur; flavanones; genetic markers; micro-computed tomography; mineralization; osteoblasts; osteocalcin; osteopenia; osteoporosis; ovariectomy; protective effect; rats; signal transduction; transcription (genetics); transcription factors
Abstract:: ... SCOPE: Yuja (Citrus junos Tanaka) possesses various health benefits, but its effects on bone health are unknown. In this study, the preventative effects of yuja peel ethanol extract (YPEE) on osteopenia were determined in ovariectomized (OVX) rats, and the mechanisms by which YPEE and its flavanones regulate osteoblastogenesis were examined in vitro. METHODS AND RESULTS: The effects of YPEE on ost ...
DOI:: 10.1002/mnfr.201600257
: https://doi.org/10.1002/mnfr.201600257

92. Elevated Lifetime Lead Exposure Impedes Osteoclast Activity and Produces an Increase in Bone Mass in Adolescent Mice

Author:: Eric E. Beier; Jonathan D. Holz; Tzong-Jen Sheu; J. Edward Puzas
Source:: Toxicological sciences 2016 v.149 no.2 pp. 277-288
ISSN:: 1096-0929
Subject:: adolescents; bone density; bone formation; calcitonin; dose response; estrogens; femur; heavy metals; humans; lead; osteoclasts; resorption; toxicology
Abstract:: ... The heavy metal lead (Pb) has a deleterious effect on skeletal health. Because bone mass is maintained through a balance of bone formation and resorption, it is important to understand the effect of Pb levels on osteoblastic and osteoclastic activity. Pb exposure is associated with low bone mass in animal models and human populations; however, the correlation between Pb dosing and corresponding bo ...
DOI:: 10.1093/toxsci/kfv234
: https://doi.org/10.1093/toxsci/kfv234

93. Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice

Author:: I-Chian Lin; Shuya Yamashita; Motoki Murata; Motofumi Kumazoe; Hirofumi Tachibana
Source:: Journal of nutritional biochemistry 2016 v.32 pp. 101-106
ISSN:: 0955-2863
Subject:: bioactive properties; bone density; bone formation; cartilage; daidzein; gene expression; inflammation; interleukin-6; metabolites; mice; osteoblasts; osteoclasts; rheumatoid arthritis; soybeans; synovitis
Abstract:: ... Rheumatoid arthritis (RA) is a chronic and systemic autoimmune inflammatory disease. Typical pathological findings of RA include persistent synovitis and bone degradation in the peripheral joints. Equol, a metabolite of the major soybean isoflavone daidzein, shows superior bioactivity than other isoflavones. We investigated the effects of equol administration on inflammatory response and bone eros ...
DOI:: 10.1016/j.jnutbio.2016.02.012
: https://doi.org/10.1016/j.jnutbio.2016.02.012

94. Escherichia coli-derived recombinant human bone morphogenetic protein-2 combined with bone marrow-derived mesenchymal stromal cells improves bone regeneration in canine segmental ulnar defects

Author:: Takamasa Itoi; Yasuji Harada; Hiroyuki Irie; Michiko Sakamoto; Katsutoshi Tamura; Takuya Yogo; Satoshi Soeta; Hajime Amasaki; Yasushi Hara; Masahiro Tagawa
Source:: BMC veterinary research 2016 v.12 no.1 pp. 201
ISSN:: 1746-6148
Subject:: Beagle; Escherichia; bone density; bone formation; bone morphogenetic proteins; dogs; females; forelimbs; humans; laboratory animals; osteoblasts; osteoclasts; stromal cells
Abstract:: ... BACKGROUND: Large bone defects in canines usually require assistance to achieve healing. Implantation of osteoinductive factors can promote bone healing, while transplantation of osteoprogenitor cells can enhance bone regeneration. We hypothesized that implantation of an osteoinductive factor, recombinant human bone morphogenetic protein-2 (rhBMP-2), combined with osteoprogenitor cells, bone marro ...
DOI:: 10.1186/s12917-016-0829-y
PubMed:: 27619812
PubMed Central:: PMC5020464
: https://doi.org/10.1186/s12917-016-0829-y

95. Evaluation of Three Human Cervical Fusion Implants for Use in the Canine Cervical Vertebral Column

Author:: Emily J. Morrison; Alan S. Litsky; Matthew J. Allen; Geoffrey T. Fosgate; Bianca F. Hettlich
Source:: Veterinary surgery 2016 v.45 no.7 pp. 901-908
ISSN:: 0161-3499
Subject:: allografting; bone density; cervical spine; dogs; humans; mechanical properties; polymethylmethacrylate; radiography; titanium
Abstract:: ... OBJECTIVE: To assess technical feasibility and mechanical properties of 3 locking plate designs (Zero‐P, Zero‐P VA, and Uniplate 2) for use in the canine cervical spine. STUDY DESIGN: Prospective ex vivo study. ANIMALS: Cadaver cervical spines from skeletally mature large breed dogs (n = 18). METHODS: Specimens were screened using radiography and allocated into balanced groups based on bone densit ...
DOI:: 10.1111/vsu.12536
: https://doi.org/10.1111/vsu.12536

96. Experimental Control for the Ovariectomized Rat Model: Use of Sham Versus Nonmanipulated Animal

Author:: Marlena C. Kruger; Patrick C. H. Morel
Source:: Journal of applied animal welfare science 2016 v.19 no.1 pp. 73-80
ISSN:: 1532-7604
Subject:: Food and Drug Administration; anesthetics; animal models; animal welfare; bone density; bone resorption; distress; ethics; osteoporosis; ovariectomy; rats; researchers; tissue repair; United States
Abstract:: ... One of 2 models required by the U.S. Food and Drug Administration for registration of a treatment for osteoporosis, the ovariectomized (OVX) rat model, is widely used in scientific studies investigating sex hormone-deficient bone loss. The use of control nonhuman animals is critical because bone turnover may be affected by animal stress, use of anesthetic, and the mechanisms involved in wound heal ...
DOI:: 10.1080/10888705.2015.1107727
: https://doi.org/10.1080/10888705.2015.1107727

97. Exploratory analysis of the potential relationship between urinary molybdenum and bone mineral density among adult men and women from NHANES 2007–2010

Author:: Ryan C. Lewis; Lauren E. Johns; John D. Meeker
Source:: Chemosphere 2016 v.164 pp. 677-682
ISSN:: 0045-6535
Subject:: National Health and Nutrition Examination Survey; adults; bone density; dose response; femur; human health; humans; lumbar spine; men; models; molybdenum; regression analysis; sex hormones; women
Abstract:: ... Human exposure to molybdenum (Mo) may play a role in reducing bone mineral density (BMD) by interfering with steroid sex hormone levels. To begin to address gaps in the literature on this topic, the potential relationship between urinary Mo (U-Mo) and BMD at the femoral neck (FN-BMD) and lumbar spine (LS-BMD) was explored in a sample of 1496 adults participating in the 2007–2010 cycles of the Nati ...
DOI:: 10.1016/j.chemosphere.2016.08.142
PubMed:: 27639340
PubMed Central:: PMC5048579
: https://doi.org/10.1016/j.chemosphere.2016.08.142

98. Factors influencing bone mass accrual: focus on nutritional aspects

Author:: H. T. Viljakainen
Source:: Proceedings of the Nutrition Society 2016 v.75 no.3 pp. 415-419
ISSN:: 1475-2719
Subject:: adolescence; bone density; calcium; childhood; foods; healthy diet; humans; infancy; nutrients; osteoporosis; randomized clinical trials; vitamin D
Abstract:: ... Until recently, much of the research exploring the role of nutrition on bone mass accrual has focused on single nutrients. Although randomised controlled trials have provided key information about the effects of calcium and vitamin D on bone, they also have limitations, e.g. generalisation, implementation of the results and long-term consequences. Human subjects do not eat single nutrients, but fo ...
DOI:: 10.1017/S0029665116000252
PubMed:: 27169333
: https://doi.org/10.1017/S0029665116000252

99. Flaxseed flour, compared to flaxseed oil, contributes to femoral structure in male rats subjected to early weaning

Author:: Carolina Ribeiro Pessanha; Bianca Ferolla da Camara Boueri; Luanna Rodrigues da Costa; Maitê Rocha Ferreira; Maíra Duque Coutinho de Abreu; Letícia Rozeno Pessoa; Aline D'Avila Pereira; Danielle Cavalcante Ribeiro; Eduardo Moreira da Silva; Carlos Alberto Soares da Costa; Gilson Teles Boaventura
Source:: Food & function 2016 v.7 no.3 pp. 1296-1300
ISSN:: 2042-650X
Subject:: animal models; biomechanics; bone density; diet; early weaning; epiphyses; femur; flour; linseed; linseed oil; males; mineral content; mothers; pups; rats
Abstract:: ... The aim of this study was to analyze whether flaxseed flour or flaxseed oil treatment contributes to femoral structure in male rats subjected to early weaning. Pups were weaned for separation from mothers at 14 days (early weaning, EW) or 21 days (control, C). After 21 days, the control (C60) was fed with the control diet. The EW group was divided based on control (EWC60), flaxseed flour (EWFF60) ...
DOI:: 10.1039/c6fo00021e
: https://doi.org/10.1039/c6fo00021e

100. Fluorosis increases the risk of postmenopausal osteoporosis by stimulating interferon γ

Author:: Yun-gang Lv; Li Kang; Guangyao Wu
Source:: Biochemical and biophysical research communications 2016 v.479 pp. 372-379
ISSN:: 0006-291X
Subject:: blood serum; bone density; bone resorption; correlation; estrogen receptors; fluorides; fluorosis; interferon-gamma; mice; osteoclasts; osteoporosis; ovariectomy; postmenopause; risk; stem cells; women
Abstract:: ... Estrogen deficiency in postmenopausal women frequently activates osteoclasts (OC), accelerates bone resorption, and leads to osteoporosis (OP). Previous studies have demonstrated that interferon γ (IFNγ) could increase bone resorption and may be involved in postmenopausal OP. Fluorosis also increased the risk of fractures and dental fluorosis, and fluoride may enhance osteoclast formation and indu ...
DOI:: 10.1016/j.bbrc.2016.09.083
: https://doi.org/10.1016/j.bbrc.2016.09.083

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1. A method of determining bending properties of poultry long bones using beam analysis and micro-CT data

2. A novel homozygous variant in SERPINH1 associated with a severe, lethal presentation of osteogenesis imperfecta with hydranencephaly

3. Alendronate-loaded hydroxyapatite-TiO₂ nanotubes for improved bone formation in osteoporotic rabbits

4. Anthocyanin-Rich Blackcurrant Extract Attenuates Ovariectomy-Induced Bone Loss in Mice

5. Association between dietary patterns and low bone mineral density among adults aged 50 years and above: findings from the North West Adelaide Health Study (NWAHS)

6. Association between the methylenetetrahydrofolate reductase c.677C>T polymorphism and bone mineral density: an updated meta-analysis

7. Association of dietary and serum vitamin E with bone mineral density in middle-aged and elderly Chinese adults: a cross-sectional study

8. Associations of breast-feeding patterns and introduction of solid foods with childhood bone mass: The Generation R Study

9. BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice

10. Behaviour, growth performance, foot pad quality, bone density, and carcass traits of broiler chickens reared with barrier perches and fed different dietary crude protein levels

11. Biomechanical evolution of solid bones in large animals: a microanatomical investigation

12. Body mass but not vitamin D status is associated with bone mineral content and density in young school children in northern Sweden

13. Bone density of elbow joints in Labrador retrievers and Golden retrievers: Comparison of healthy joints and joints with medial coronoid disease

14. Bone health nutraceuticals alter microarray mRNA gene expression: A randomized, parallel, open-label clinical study

15. CLA Has a Useful Effect on Bone Markers in Patients with Rheumatoid Arthritis

16. Can a healthy life prevent us from post-menopausal osteoporosis? Myths and truths

17. Collagens VI and XII form complexes mediating osteoblast interactions during osteogenesis

18. Combinations of physical activity, sedentary behaviour and sleep: relationships with health indicators in school-aged children and youth1

19. Cysteic Acid in Dietary Keratin is Metabolized to Glutathione and Liver Taurine in a Rat Model of Human Digestion

20. Danshen enhanced the estrogenic effects of Qing E formula in ovariectomized rats

21. Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women

22. Direct Covalent Grafting of Phytate to Titanium Surfaces through Ti–O–P Bonding Shows Bone Stimulating Surface Properties and Decreased Bacterial Adhesion

23. Effects of Proton Pump Inhibitor Administration and Intake of a Combination of Yogurt and Galactooligosaccharides on Bone and Mineral Metabolism in Rats

24. Estrogen-like osteoprotective effects of glycine in in vitro and in vivo models of menopause

25. Evaluation of chronological changes in bone fractures and age-related bone loss: A test case from Poland

26. Experimental osteoporosis in sheep – mechanical and histological approach

27. Fgf23 and parathyroid hormone signaling interact in kidney and bone

28. High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice

29. Housing conditions alter properties of the tibia and humerus during the laying phase in Lohmann white Leghorn hens

30. Lean Mass and Body Fat Percentage Are Contradictory Predictors of Bone Mineral Density in Pre-Menopausal Pacific Island Women

31. Low level laser therapy accelerates bone healing in spinal cord injured rats

32. Maternal dietary vitamin D carry-over alters offspring growth, skeletal mineralisation and tissue mRNA expressions of genes related to vitamin D, calcium and phosphorus homoeostasis in swine

33. Methyl jasmolate treated buckwheat sprout powder enhances glucose metabolism by potentiating hepatic insulin signaling in estrogen-deficient rats

34. MiR-132 regulates osteogenic differentiation via downregulating Sirtuin1 in a peroxisome proliferator-activated receptor β/δ–dependent manner

35. Micro‐CT Structural Analysis of the Canine Medial Coronoid Disease

36. Mutan: A mixed linkage α-[(1,3)- and (1,6)]-d-glucan from Streptococcus mutans, that induces osteoclast differentiation and promotes alveolar bone loss

37. Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation

38. Osteoblastogenic activity of ark shell protein hydrolysates with low molecular weight in mouse mesenchymal stem cells

39. PUFAs, Bone Mineral Density, and Fragility Fracture: Findings from Human Studies

40. Periostin action in bone

41. Porcine placenta hydrolysates enhance osteoblast differentiation through their antioxidant activity and effects on ER stress

42. Preference for and use of oral enrichment objects in juvenile silver foxes (Vulpes vulpes)

43. Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo : Clearwater Beach, FL, USA. 9-11 June 2016

44. Quantitative comparison of bone mineral density characteristics of the distal epiphysis of third metacarpal bones from Thoroughbred racehorses with or without condylar fracture

45. Quantitative proteomics and integrative network analysis identified novel genes and pathways related to osteoporosis

46. Serum concentrations of 25-hydroxyvitamin D and its association with bone mineral density and serum parathyroid hormone levels during winter in urban males from Guiyang, Southwest China

47. Sialoglycoprotein Isolated from Eggs of Carassius auratus Ameliorates Osteoporosis: An Effect Associated with Regulation of the Wnt/β-Catenin Pathway in Rodents

48. Skeletal effects of growth hormone and insulin-like growth factor-I therapy

49. TIEG1 enhances Osterix expression and mediates its induction by TGFβ and BMP2 in osteoblasts

50. The effects of different levels of calcium supplementation on the bone mineral status of postpartum lactating Chinese women: a 12-month randomised, double-blinded, controlled trial

51. The in vivo effects of a fraction from Dioscorea spongiosa on glucocorticoid-induced osteoporosis

52. The systemic effects of sclerostin overexpression using ΦC31 integrase in mice

53. A 7-Year Longitudinal Trial of the Safety and Efficacy of a Vitamin/Mineral Enhanced Plant-Sourced Calcium Supplement

54. A Prospective, Placebo‐Controlled Pilot Evaluation of the Effect of Omeprazole on Serum Calcium, Magnesium, Cobalamin, Gastrin Concentrations, and Bone in Cats

55. A prospective follow up of age related changes in the subchondral bone density of the talus of healthy Labrador Retrievers

56. A randomized, controlled trial evaluating the efficacy of an online intervention targeting vitamin D intake, knowledge and status among young adults

57. Adiposity is associated with early reduction in bone mass in pediatric inflammatory bowel disease

58. Akt drives buffalo casein-derived novel peptide-mediated osteoblast differentiation

59. Anti-osteoporotic activity of harpagide by regulation of bone formation in osteoblast cell culture and ovariectomy-induced bone loss mouse models

60. Anti-osteoporotic effects of Pueraria candollei var. mirifica on bone mineral density and histomorphometry in estrogen-deficient rats

61. Association between dietary iron intake and bone mineral density: A cross‐sectional study in Chinese population

62. Biological Silicon Stimulates Collagen Type 1 and Osteocalcin Synthesis in Human Osteoblast-Like Cells Through the BMP-2/Smad/RUNX2 Signaling Pathway

63. CT Imaging Biomarkers of Bone Damage Induced by Environmental Level of Cadmium Exposure in Male Rats

64. Calcium plus vitamin D supplementation during pregnancy interacts with polymorphisms in the promoter region of the VDR gene to affect postpartum bone mass of Brazilian adolescent mothers: A randomized controlled trial

65. Cdx-2 polymorphism in Vitamin D Receptor gene was associated with serum 25-hydroxyvitamin D levels, bone mineral density and fracture in middle-aged and elderly Chinese women

66. Chronic lead poisoning magnifies bone detrimental effects in an ovariectomized rat model of postmenopausal osteoporosis

67. Collected literature on isoflavones and chronic diseases

68. Comparison of black, green and rooibos tea on osteoblast activity

69. Comparisons among radiography, ultrasonography and computed tomography for ex vivo characterization of stifle osteoarthritis in the horse

70. Consumption of onion juice modulates oxidative stress and attenuates the risk of bone disorders in middle-aged and post-menopausal healthy subjects