An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
... Alcohol intake has been associated with preventive as well as negative effects on health. However, the intake estimates are often based on subjective reporting and therefore biased and the types of beverages consumed are often inaccurately reported. Accurate and specific quantification of alcohol related compounds in biological samples may help to understand dietary exposure and metabolic kinetics ...
... Indospicine (l-2-amino-6-amidinohexanoic acid) is a natural hepatotoxin found in all parts of some Indigofera plants such as Indigofera linnaei and Indigofera spicata. Several studies have documented a susceptibility to this hepatotoxin in different species of animals, including cattle, sheep, dogs, and rats, which are associated with mild to severe liver disease after prolonged ingestion. However ...
acrylamides; body weight; coffee (beverage); dietary exposure; ferrocyanides; formic acid; issues and policy; lowest observed effect level; methanol; no observed adverse effect level; potassium; public health; risk; risk assessment; risk communicators; stakeholders; vending machines; zinc acetate
Abstract:
... The present study aimed to evaluate the levels of acrylamide in coffee brews acquired from coffee vending machines. Acrylamide content ranged from 7.7 to 40.0μg/L (mean: 20.6μg/L). These levels are similar to those found in coffee brews prepared by other coffee machines with different extraction procedures. The dietary exposure of the Spanish population to acrylamide through coffee drinks was esti ...
... The sub-acute toxicity of E. faecalis HZNU P2 was investigated in rats fed with different doses for 14 days. To evaluate the acute oral toxicity of E. faecalis HZNU P2, rats were fed with E. faecalis HZNU P2 at a high dose of 2×10 ¹¹ CFU kg ⁻¹ for 10 days. Results showed that there were no abnormal clinical signs in any of the groups during the experiment. There were no significant differences in ...
... In the present study, a total of 358 samples consisting of raw milk of cow (n = 64), goat (n = 56) and sheep (n = 52); traditional cheese (n = 40), yoghurt (n = 42), Kashk (n = 40), Doogh (n = 44) and Tarkhineh (n = 20) were analyzed for aflatoxin M1 (AFM1) by using an enzyme linked immunosorbent assay (ELISA). Frequency of AFM1 and its concentration ranges in the ELISA positive samples were deter ...
... Glyphosate is a herbicide used to control broad-leaved weeds. Some uses of glyphosate in crop production can lead to residues of the active substance and related metabolites in food. This paper uses data on residue levels, processing information and consumption patterns, to assess theoretical lifetime dietary exposure to glyphosate.Initial estimates were made assuming exposure to the highest permi ...
Western diets; advanced glycation end products; butter; canned meat; databases; dietary exposure; food choices; food matrix; fruits; grain products; human health; lysine; tandem mass spectrometry; ultra-performance liquid chromatography; vegetables
Abstract:
... The aim of this study was to validate an ultra-performance liquid chromatography tandem mass-spectrometry (UPLC–MS/MS) method for the determination of advanced glycation endproducts (AGEs) in food items and to analyze AGEs in a selection of food items commonly consumed in a Western diet. Nε-(carboxymethyl)lysine (CML), Nε-(1-carboxyethyl)lysine (CEL) and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-orn ...
animals; cellulose; chemical bonding; chlorides; cotton fabric; dietary exposure; durability; irradiation; laundry; multiple drug resistance; polymerization; public health; skin irritation; toxicity testing
Abstract:
... Multidrug-resistant superbugs are currently a severe threat to public health. Here, we report a novel kind of antisuperbug material prepared by irradiation induced graft polymerization of 1-butyl-3-vinyl imidazole chloride onto cotton fabric. The reduction of superbugs on this fabric is higher than 99.9%. Attributed to the strong covalent bonding between the graft chains and the cellulose macromol ...
... Consumption of vegetables grown in arsenic (As)-contaminated soils is an important exposure route to the element for humans. The present study is focused on locally-grown, frequently-consumed vegetables, such as carrots (Daucus carota), beets (Beta vulgaris) and quinoa (Chenopodium) from the As-polluted Chiu Chiu area in Northern Chile. The latter region is affected both by As discharge from coppe ...
Copepoda; phytoplankton; bioaccumulation; phenanthrenes; anthracenes; marine ecosystems; dietary exposure; solvents; Rhodomonas; water uptake; keystone species; zooplankton; gas chromatography-mass spectrometry
Abstract:
... Laboratory exposure experiments were performed on the marine coastal zooplankton species Pseudodiaptomus marinus—a keystone species of vast Atlantic and Pacific marine ecosystems, tracing the accumulation of three polycyclic aromatic hydrocarbons (PAHs): phenanthrene, anthracene and pyrene. The experiment was designed to study the bioconcentration of PAHs in phytoplankton (Rhodomonas baltica) and ...
Bowen Du; Samuel P. Haddad; Andreas Luek; W. Casan Scott; Gavin N. Saari; S. Rebekah Burket; Christopher S. Breed; Martin Kelly; Linda Broach; Joseph B. Rasmussen; C. Kevin Chambliss; Bryan W. Brooks
... Though pharmaceuticals and other contaminants of emerging concern are increasingly observed in inland water bodies, the occurrence and bioaccumulation of pharmaceuticals in estuaries and coastal ecosystems are poorly understood. In the present study, bioaccumulation of select pharmaceuticals and other contaminants of emerging concern was examined in fish from Buffalo Bayou, a tidally influenced ur ...
heavy metals; lead; urban areas; dietary exposure; urbanization; risk; bioavailability; cadmium; human health; risk assessment; industrialization; cities; point source pollution; health effects assessments; United States Environmental Protection Agency; humans; models; developing countries; soil; chromium; traffic; food intake; therapeutics; industrial effluents; nickel; vegetables; environmental monitoring
Abstract:
... A verity of human activities i.e. urbanization and industrialization have been resulted serious environmental contaminations by heavy metals in all over the world. The settlement of populations in urban and nearby industrial areas for economic development has significant share in their exposure to these metallic contaminants. Depending on the nature and type of the pollutants, targeted urban-indus ...
... Acrylamide (AA) is a process-contaminant that potentially increases the risk of developing cancer in humans. AA is formed during heat treatment of starchy foods and detected in a wide range of commonly consumed products. Increased focus on risk ranking and prioritization of major causes of disease makes it relevant to estimate the impact that exposure to chemical contaminants and other hazards in ...
... In the present study, the chronic cumulative exposure to organophosphorus (OPs), carbamates (CBs) and pyrethroid and pyrethrin (PPs) pesticides in the region of Valencia through fruit and vegetables consumption is presented. A total of 752 samples and 84 pesticides were studied of which, 52 were OPs, 23 CBs and 9 PPs. Residue data were derived from the Valencia Region monitoring program 2007–2011 ...
American Indians; Veneroida; adults; algae; beaches; children; cognition; diet; dietary exposure; domoic acid; humans; long term effects; longevity; longitudinal studies; risk; toxicity
Abstract:
... The CoASTAL cohort represents the first community cohort assembled to study a HAB-related illness. It is comprised of three Native American tribes in the Pacific NW for the purpose of studying the health impacts of chronic, low level domoic acid (DA) exposure through razor clam consumption. This cohort is at risk of DA toxicity by virtue of their geographic location (access to beaches with a histo ...
... Anthocyanins are responsible for the red/blue colour of grapes, currants, and other fruits and vegetables. They may also be extracted for use as colour additives (E163) or concentrated for use as colouring foods. Consumer exposures have been assessed using data on natural occurrence, use levels and frequencies from food manufacturers and European food consumption data. Intakes from natural occurre ...
DDE (pesticide); DDT (pesticide); adverse effects; biphenyl; blood sampling; body mass index; breast feeding; children; cohort studies; diet; dietary exposure; excretion; flame retardants; hexachlorobenzene; persistent organic pollutants; pharmacokinetics; polybrominated diphenyl ethers; polychlorinated biphenyls; pregnancy; pregnant women
Abstract:
... Exposure to persistent organic pollutants (POPs) during prenatal and postnatal life has been extensively studied in relation to adverse health effects in children.The aim was to identify determinants of the concentrations of polychlorinated biphenyls (PCBs), brominated flame retardants (polybrominated diphenyl ethers, PBDEs; polybrominated biphenyl, PBB), and organochlorine pesticides (OCPs) in bl ...
detection limit; dietary exposure; fish; flame retardants; high performance liquid chromatography; mass spectrometry; mirex; monitoring; pollutants; silica; vegetable oil; Spain
Abstract:
... Dechlorane Plus (DP) is a flame retardant used as a substitute of Mirex since 1970s, but it was not detected in the environment until 2006. Since then, this compound and its main relatives, Dechlorane 602, 603 and 604, have been mainly studied in environmental matrices for monitoring purposes, but the dietary exposure to them has been hardly investigated so far. In the present study, we determined ...
... Maize plants expressing dsRNA for the management of Diabrotica virgifera virgifera are likely to be commercially available by the end of this decade. Honey bees, Apis mellifera, can potentially be exposed to pollen from transformed maize expressing dsRNA. Consequently, evaluation of the biological impacts of RNAi in honey bees is a fundamental component for ecological risk assessment. The insectic ...
M. P. Beker; P. Boari; M. Burachik; V. Cuadrado; M. Junco; S. Lede; M. A. Lema; D. Lewi; A. Maggi; I. Meoniz; G. Noé; C. Roca; C. Robredo; C. Rubinstein; C. Vicien; A. Whelan
... Experience gained in the risk assessment (RA) of genetically engineered (GE) crops since their first experimental introductions in the early nineties, has increased the level of familiarity with these breeding methodologies and has motivated several agencies and expert groups worldwide to revisit the scientific criteria underlying the RA process. Along these lines, the need to engage in a scientif ...
... Diarylheptanoids from Alnus nepalensis leaves have been reported for promising activity against filariasis, a mosquito‐borne disease, and this has prompted us to investigate its anti‐malarial and safety profile using in‐vitro and in‐vivo bioassays. A. nepalensis leaf extracts were tested in‐vitro against chloroquine‐sensitive Plasmodium falciparum NF54 by measuring the parasite specific lactate de ...
... With rapid industrialization and modernization in China, long-term dietary exposure to cadmium (Cd) has the potential to cause health risks. The traditional probabilistic approach for long-term dietary assessment was a semi-probabilistic method that had limitations in qualifying the variation in concentration data. Thus, this article estimated the long-term dietary exposure to Cd of the adults of ...
Total Diet Study; acrylamides; dietary exposure; food groups; food intake; grains; human health; mammary neoplasms (animal); mice; potatoes; rats; risk; toxicology; China
Abstract:
... The levels of acrylamide in 240 food composite samples from the 5th Chinese Total Diet Study (TDS) were measured using an LC-MS/MS method and the exposure estimates for the general population were evaluated. The samples were collected from 20 provinces in China, covering about two thirds of the Chinese population. Acrylamide was detected in 40.0% of composite samples with the concentrations ranged ...
... Aflatoxins, fumonisins and ochratoxin A that contaminate various agricultural commodities are considered of significant toxicity and potent human carcinogens. This study took a total dietary study approach and estimated the dietary exposure of these mycotoxins for adults living in Lao Cai province, Vietnam. A total of 42 composite food samples representing 1134 individual food samples were prepare ...
... Lead, a ubiquitous heavy metal, can be found in the environment and food. The present study is the first to estimate the lead dietary exposure of Shenzhen adults (≥ 20 years old) in various age–gender subgroups, and to assess the associated health risk. Food samples that represented the Shenzhen people’s dietary pattern were collected and prepared for analysis. Lead was determined in 13 food group ...
... Seabirds are ideal model organisms to track mercury (Hg) through marine food webs as they are long-lived, broadly distributed, and are susceptible to biomagnification due to foraging at relatively high trophic levels. However, using these species as biomonitors requires a solid understanding of the degree of species, sexual and age-specific variation in foraging behaviors which act to mediate thei ...
detection limit; dietary exposure; half life; harvest date; liquid chromatography; mammals; models; soil; soybeans; straw; tandem mass spectrometry; China
Abstract:
... This work is the first report on the dissipation and final residue of cloransulam-methyl on soybean plant at field conditions. A fast, simple, and reliable residue analytical method for determination of cloransulam-methyl in soybean matrices and soil was developed based on quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample preparation and liquid chromatography-tandem mass spectromet ...
... 2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47), a compound manufactured for use as a flame retardant, is a ubiquitous environmental contaminant and suspected endocrine disruptor. Though several studies have explored the reproductive effects of BDE-47 in adult fish, there is a paucity of data regarding the reproductive effects of early life stage exposure. The goal of this study was to assess the repr ...
... T-2 toxin (T-2) is a trichothecene-A-type mycotoxin produced by the fungus Fusarium spp., which can contaminate animal feed. It is toxic to many living cells especially the hepatocytes and bone marrow cells. The effects of dietary T-2 on growth, biochemical and immunity parameters, and histopathological changes in the hepatopancreas of white shrimp (Litopenaeus vannamei) were studied. Shrimp with ...
... Understanding the nanomaterial potential to the food conversion of two food chain levels is important in the ecosystem assessment as manufactured nanomaterials are being released into the environment. In this investigation, the food conversion from Daphnia magna (D. magna) (prey) to Danio rerio (D. rerio) (predator) was used as the study object of aqueous stable fullerene nanocrystals (nC60). Accu ...
Xenopus laevis; body weight; dietary exposure; ecotoxicology; epithelium; homeostasis; hypertrophy; mechanism of action; metamorphosis; odors; particulates; pollutants; tadpoles; thyroid gland
Abstract:
... The compound 1,3,4,6,7,8‐hexahydro‐4,6,6,7,8,8‐hexamethylcyclopenta‐[γ]‐2‐benzopyrane (HHCB; galaxolide, Chemical Abstracts Service number 1222‐05‐5) is a synthetic musk used extensively as a fragrance in many consumer products and classified as an emerging pollutant. The ecotoxicological information available for HHCB addresses exposure via water, but this compound is frequently adsorbed into par ...
... Risk assessment of pesticides has been based on direct toxic effects on aquatic organisms. Indirect effects data are taken into account but with limitations, as it is frequently difficult to predict their real impacts in the ecosystems. In this context the main aim of this work was to assess how the exposure to the herbicide pendimethalin (Prowl®), under environmentally relevant concentrations, ma ...
Monte Carlo method; Total Diet Study; air; antimony; arsenic; bioavailability; cadmium; children; chromium; chronic exposure; copper; dietary exposure; dust; humans; ingestion; lead; manganese; soil; strontium; tap water; toxicity; France
Abstract:
... Children are exposed to toxic metals and metalloids via their diet and environment. Our objective was to assess the aggregate chronic exposure of children aged 3–6years, living in France, to As, Cd, Cr, Cu, Mn, Pb, Sb, Sr, and V present in diet, tap water, air, soil and floor dust in the years 2007–2009. Dietary data came from the French Total Diet Study, while concentrations in residential tap wa ...
adults; chicken eggs; children; community gardens; dietary exposure; fruits; gardeners; gardening; healthy diet; horticultural soils; human health; lead; raised beds; risk; urban population; vegetable consumption; vegetables; New York
Abstract:
... Urban community gardens provide affordable, locally grown, healthy foods and many other benefits. However, urban garden soils can contain lead (Pb) that may pose risks to human health. To help evaluate these risks, we measured Pb concentrations in soil, vegetables, and chicken eggs from New York City community gardens, and we asked gardeners about vegetable consumption and time spent in the garden ...
... Probabilistic estimation of dietary exposure to DON, including its acetylated derivatives, and type B trichothecenes from cereals and cereal-based products in Chinese populations was investigated in the current work. Different cut-offs as proposed Maximum levels (MLs) for DON in various raw cereals and/or cereal-based foods were assessed based on the risk assessment results. Occurrence data was do ...
... Fumonisins are mycotoxins produced by Fusarium species and affecting maize crops. Some analogues of fumonisins are known for their toxic and possible carcinogenic effects on humans and animals. Because of their occurrence in corn-based food, diet is the main source of exposure to these mycotoxins, especially among people affected by celiac disease. Hence, the purpose of this paper was to evaluate ...
National Health and Nutrition Examination Survey; artificial colors; boys; breakfast cereals; children; color; databases; desserts; dietary exposure; drugs; food intake; food records; frozen yogurt; ice cream; juices; nutrient intake; product labeling; soft drinks; United States
Abstract:
... Dietary exposures to the seven food, drug, and cosmetic (FD&C) colour additives that are approved for general use in food in the United States were estimated for the US population (aged 2 years and older), children (aged 2–5 years) and teenage boys (aged 13–18 years) based on analytical levels of the FD&C colour additives in foods. Approximately 600 foods were chosen for analysis, based on a surve ...
... Organohalogen pollutants (OHPs) including chlorinated paraffins (CPs), polybrominated diphenyl ethers (PBDEs) and other halogenated flame retardants (OHFRs) (dechlorane plus (DP), decabromodiphenyl ethane (DBDPE), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), hexabromobenzene (HBB), hexabromocyclododecanes (HBCDs) and tetrabromobisphenol A (TBBPA)) originating from an e-waste recycling area in Gu ...
Basella alba; cadmium; copper; dietary exposure; freshwater; groundwater; health effects assessments; heavy metals; irrigation management; irrigation water; lead; risk; salinity; textile mill effluents; vegetables; wastewater; wastewater irrigation; water reuse; zinc
Abstract:
... PURPOSE: The aim of this research was to assess the health risk of textile wastewater reuse as irrigation water on leafy vegetable (Basella alba) by comparing variable growth rate in different ration of wastewater and freshwater irrigation and assess their soil-to-plant transfer factor (TF) and health risk index (HRI). METHODS: Pot experiments were laid out with five treatments including control w ...
... Little is known about the propensity of crocodilians to bioaccumulate trace elements as a result of chronic dietary exposure. We exposed 36 juvenile alligators (Alligator mississippiensis) to one of four dietary treatments that varied in the relative frequency of meals containing prey from coal combustion waste (CCW)-contaminated habitats vs. prey from uncontaminated sites, and evaluated tissue re ...
... 1,2,5,6,9,10-hexabromocyclododecane (HBCD) is a brominated flame retardant that is used worldwide in expanded and extruded polystyrene foam and simultaneously emitted to the environment. HBCD can easily accumulate in animals and humans and cause neurotoxicity, thyroid hormone disruption, and reproductive disorders. Therefore, it is essential to monitor the HBCD concentrations in foods and estimate ...
Fusarium; animal and human health; deoxynivalenol; dietary exposure; duodenum; fungi; gilts; granules; inflammation; macrophages; mucosa; plasma cells; risk factors; zearalenone
Abstract:
... Deoxynivalenol (DON) and zearalenone (ZEN), produced by microfungi of the Fusarium family, are among the most commonly occurring mycotoxins. They are considered important factors affecting human and animal health as well as livestock productivity. The aim of this study was to determine the effect of low doses of these mycotoxins on the histological structure of the pig duodenum. The study was perf ...
aggregate exposure; indirect contact; ingestion; blood serum; humans; exposure scenario; direct contact; pharmacokinetics; average daily intake; tap water; dietary exposure; dust; sulfonic acids; toddlers; carboxylic acids; breathing; alcohols; adults; Korean Peninsula
Abstract:
... A wide range of per- and polyfluoroalkyl substances (PFASs), including fluorotelomer alcohols (FTOHs), perfluorooctane sulfonamidoethanols (FOSEs), perfluoroalkyl carboxylic acids (PFCAs), and perfluoroalkane sulfonic acids (PFSAs), were measured in fifteen house dust and two nonresidential indoor dust of Korea. Total concentrations of PFASs in house dust ranged from 29.9 to 97.6ngg−1, with a domi ...
Ana Karina M.F. Lustosa; Daniel D.R. Arcanjo; Rayra G. Ribeiro; Klinger Antonio F. Rodrigues; Flávia Franceli B. Passos; Celyane A. Piauilino; José Couras Silva-Filho; Bruno Q. Araújo; José S. Lima-Neto; Joaquim S. Costa-Júnior; Fernando Aécio A. Carvalho; Antônia Maria das Graças L. Citó
Platonia insignis; acute toxicity; biodiversity; cytotoxicity; diarrhea; dietary exposure; erythrocytes; females; guidelines; hemolysis; immunomodulation; in vitro studies; in vivo studies; indigenous species; macrophages; medicinal plants; mice; nitric oxide; nitrites; phagocytosis; rats; seed extracts; seeds; Amazonia; Brazil
Abstract:
... The “bacuri” (Platonia insignis Mart., Clusiaceae) is a native tropical fruit from the Brazilian Amazon and Northeast Regions. Its seeds are used to treat inflammatory diseases, diarrhea and skin problems in traditional medical practices. Regarding its widespread medicinal uses, it is important to evaluate the biological and toxicological potential of this species. This way, the aim of this study ...
... Polycyclic aromatic hydrocarbons (PAH) are common dietary exposures that cross the human placenta and are classified as a probable human carcinogen. The aim of the present study was to investigate the potential impact of exposure to PAH-containing meat consumed during pregnancy on birth outcomes. Prospective birth cohort study. Only non-smoking women with singleton pregnancies, who were free from ...
bisphenol A; consumer preferences; diet; dietary exposure; environmental monitoring; finishing; lifestyle; metabolites; phthalates; plastics; toys; urine; Europe; United States
Abstract:
... Exposure to bisphenol-A (BPA) and phthalates has been associated with negative health outcomes in animal and human studies, and human bio-monitoring studies demonstrate widespread exposure in the US and Europe. Out of concern for the environment and health, individuals may attempt to modify their environment, diet, and consumer choices to avoid such exposures, but these natural experiments are rar ...
... Rice ingestion is an important dietary exposure pathway for methylmercury. There are few studies concerning prenatal methylmercury exposure through rice ingestion, yet the health risks are greatest to the developing fetus, and thus should be investigated.Our main objective was to quantify dietary methylmercury intake through rice and fish/shellfish ingestion among pregnant mothers living in southe ...
... Accumulation of persistent organic pollutants (POPs) has been linked to adipose tissue expansion. As different nutrients modulate adipose tissue development, we investigated the influence of dietary composition on POP accumulation, obesity development and related disorders. Lifespan was determined in mice fed fish-oil-based high fat diets during a long-term feeding trial and accumulation of POPs w ...
... Studies on metabolism of polyphenols have revealed extensive transformations in the carbon backbone by colonic microbiota; however, the influence of microbial and hepatic transformations on human urinary metabolites has not been explored. Therefore, the aims of this study were (1) to compare the in vitro microbial phenolic metabolite profile of foods and beverages with that excreted in urine of su ...
... Tree swallows (Tachycineta bicolor) nesting near oilsands development in northern Alberta are potentially exposed to elevated levels of metals. The objective of this study was to determine whether levels of metals and metalloid elements in dietary items and tissues of nestling tree swallows inhabiting areas near oilsands mine operations were higher compared to those of reference sites. We hypothes ...
Vigna unguiculata; acceptable daily intake; average daily intake; carbofuran; cowpeas; dietary exposure; monitoring; omethoate; pesticide residues; phoxim; public health; pyrethrins; risk; screening; triazophos; China
Abstract:
... To monitor pesticide residues in cowpea and assess the potential public health risk, 433 fresh cowpea samples from Hainan province (2012 and 2013) were collected and the presence of 20 organophosphoate, carbamate and pyrethroid was determined. A screening analysis consisting of a dietary exposure assessment of pesticide residue was performed using a deterministic approach-point estimate of exposur ...
... The effects of digestible carbohydrates, fructose in particular, on the development of metabolic disturbances remain controversial. We explored the effects of prolonged consumption of high-fat diets differing in their carbohydrate source on fat deposits in the adult Yucatan minipig. Eighteen minipigs underwent computed tomographic imaging and blood sampling before and after 8 weeks of three isocal ...
... Background: There is some evidence that increased maternal intake of omega-3 (n–3) long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may reduce the incidence of immunoglobulin E (IgE)–mediated allergic disease. Objective: We aimed to evaluate prenatal n–3 LC-PUFA dietary exposure in observational studies and n–3 LC-PUFA supplementation in randomized controlled trials (RCTs) on out ...
Oncorhynchus kisutch; Oncorhynchus mykiss; Oncorhynchus tshawytscha; Salmo trutta; dietary exposure; fatty acids; fatty fish; fish consumption; fish eggs; fish fillets; furans; government agencies; minerals; models; naphthalenes; polybrominated diphenyl ethers; polychlorinated biphenyls; polychlorinated dibenzodioxins; polychlorinated dibenzofurans; prediction; proteins; risk; toxicity; vitamins; Lake Ontario
Abstract:
... Fish consumption is associated with both health benefits from high-quality proteins, minerals, vitamins, and fatty acids and risks from contaminants in fish. Fish consumption advisories are issued by many government agencies to keep exposure to contaminants at a safe level. Such advisories are typically based on fillets and neglect consumption of other fish parts such as eggs by certain subpopulat ...
... The choice of suitable normal foods is limited for individuals with particular medical conditions, e.g., inborn errors of metabolism (phenylketonuria – PKU) or severe cow’s milk protein allergy (CMPA). Patients may have dietary restrictions and exclusive or partial replacement of specific food groups with specially formulated products to meet particular nutrition requirements. Artificial sweetener ...
boiling; cleaning; cypermethrin; dietary exposure; fungicides; gas chromatography; nutrition assessment; ozonation; ozone; pesticide residues; physicochemical properties; principal component analysis; risk; risk assessment; strawberries; tap water; ultrasonics; washing
Abstract:
... The effects of washing with tap and ozone water, ultrasonic cleaning and boiling on 16 pesticide (ten fungicides and six insecticides) residue levels in raw strawberries were investigated at different processing times (1, 2 and 5 min). An analysis of these pesticides was conducted using gas chromatography with nitrogen-phosphorous and electron capture detection (GC-NPD/ECD). The processing factor ...
acceptable daily intake; air; bisphenol A; blood; breast milk; containers; creatinine; dietary exposure; drugs; dust; epoxides; females; food frequency questionnaires; food safety; geometry; males; plastics; regression analysis; reproductive toxicology; resins; risk assessment; urine; Europe; Korean Peninsula; North America
Abstract:
... Bisphenol A (BPA) is a high-volume industrial chemical used in the global production of polycarbonate plastics and epoxy resins, which are used in food and drink containers, such as tableware (plates and mugs). Due to its broad applications, BPA has been detected in human blood, urine and breast milk as well as environmental substances, including water, indoor and outdoor air, and dust. Indeed, ex ...
... Aquatic organisms take up selenium from solution and from their diets. Many questions remain regarding the relative importance of selenium accumulation from these sources and resulting effects in benthic invertebrates. The present study addressed the toxicity and accumulation of Se via dissolved and dietary exposures to three different Se species, in the freshwater oligochaete Lumbriculus variegat ...
Ida Henriette Caspersen; Heidi Aase; Guido Biele; Anne Lise Brantsæter; Margaretha Haugen; Helen Engelstad Kvalem; Annette Holth Skogan; Pål Zeiner; Jan Alexander; Helle Margrete Meltzer; Helle K. Knutsen
... Polychlorinated dibenzo-p-dioxins/dibenzofurans (dioxins) and polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) with potentially adverse impact on child neurodevelopment. Whether the potential detrimental effects of dioxins and PCBs on neurodevelopment are of specific or unspecific character is not clear.The purpose of the current study was to examine the influence of mater ...
... In the present study, the Hg contamination in mariculture sites located at the estuary of Pearl River was to investigate with an attempt to analyse associated health risks of dietary exposure to both total mercury (THg) and methyl mercury (MeHg) in cultured fish and shellfish. The highest total mercury concentration (7.037 ± 0.556 ng L−1) of seawater was observed at Zhuhai Estuary. The Hg concentr ...
... Ingestion of indospicine-contaminated camel and horse meat has caused fatal liver injury to dogs in Australia, and it is currently not known if such contaminated meat may pose a human health risk upon dietary exposure. To date, indospicine-related research has tended to focus on analytical aspects, with little information on post-harvest management of indospicine-contaminated meat. In this study, ...
Valentina Lorenzi; Sergio Ghidini; Barbara Angelone; Enrica Ferretti; Simonetta Menotta; Giorgio Fedrizzi; Giorgio Varisco; Stefano Foschini; Giuseppe Diegoli; Luigi Bertocchi
... In the three-years period 2012–2014, 160 cow milk samples from farms located in Lombardy and Emilia Romagna regions (Italy) were analyzed during the implementation of the Italian National Residues Monitoring Plan to assess the presence of PCDD/F, DL-PCB and NDL-PCB residues. The obtained contamination data were combined with cow milk consumption data from the Italian national dietary survey to est ...
... The presence of Al, As, Ba, Cd, Cr, Cu, Fe, Mn, Ni, Pb, Se, and Zn in 30 samples of tea (Camellia sinensis) purchased from markets in southeastern Brazil were evaluated by ICP-MS. This study was performed for both tea leaves and their infusions. The results provide data that permits an evaluation of the exposure or dietary intake of these trace elements. For some samples, the levels in the tea lea ...
... Washing of iceberg lettuce with HOCl solutions in concentrations ranging from 1.41 to 141mg/L resulted in 0.69 to 2.05μg3-chlorotyrosine/g vegetable. As also six commercial ready-to-eat iceberg lettuces from different producers contained 3-chlorotyrosine from 1.00 to 2.24μg/g vegetable, a total of 122 ready-to-eat vegetable samples purchased in Belgian supermarkets were further screened for their ...
... Application of manure, biosolids, and recycled wastewater to croplands could be a potential pathway through which trace organic compounds (TOrCs) may be taken up by food crops. We present a framework to prepare a short list of TOrCs for detailed risk assessment and evaluation in terms of bioaccumulation. The framework was modified from Lipinski’s method to predict drug permeability based on four c ...
... Quantitative Structure Activity Relationship (QSAR) models are expected to play an important role in the risk assessment of chemicals on humans and the environment. In this study, we developed a validated QSAR model to predict acute oral toxicity of 329 pesticides to rats because a few QSAR models have been devoted to predict the Lethal Dose 50 (LD50) of pesticides on rats. This QSAR model is base ...
... As an essential element, selenium (Se) is beneficial at low levels yet toxic at high levels. The present study assessed the effects of dietary exposure to Se in the least killifish Heterandria formosa, and investigated how this exposure influences the effects of a subsequent exposure to cadmium (Cd). The fish were pre-exposed to an environmentally relevant concentration (2 μg g−1 dry wt) of dietar ...
... A mycotoxin-dedicated total diet study (mTDS) allowing assessment of occurrence and dietary exposure to these substances was developed and carried out in the Netherlands in 2013. First, literature was searched to establish the occurrence profile of mycotoxins. Next, foods as consumed according to the Dutch National Food Consumption Surveys (DNFCS) for young children and persons aged 7-69 years, ca ...
Pituophis; Thomomys talpoides; active ingredients; adults; basins; burrows; cropland; demographic statistics; diet; dietary exposure; females; geographic information systems; gophers; habitats; land cover; models; neurotoxins; orchards; poisoning; population density; population size; risk; rodenticides; snakes; strychnine; vineyards; British Columbia
Abstract:
... Strychnine is a neurotoxin and an active ingredient in some rodenticides which are placed in burrows to suppress pocket gopher (Thomomys talpoides) populations in range and crop land in western North America. The population level impact was modelled of the use of strychnine-based rodenticides on a non-target snake species, the Great Basin Gophersnake (Pituophis catenifer deserticola), which is a p ...
average daily intake; dietary exposure; fish; fish consumption; freshwater; ingestion; neoplasms; nutrition assessment; polychlorinated biphenyls; risk; socioeconomics; toxicity; India
Abstract:
... The objective of this study is to determine the concentrations of polychlorinated biphenyls (PCBs) in different fish species collected from fish outlets in the south Indian city of Hyderabad. The samples of fish extracted by using Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) and concentrations of polychlorinated biphenyls (PCBs, 45 congeners) were determined by gas chromatography–mic ...
... Heterocyclic aromatic amines (HCA) are carcinogenic mutagens formed during cooking of protein-rich foods. HCA residues adducted to blood proteins have been postulated as biomarkers of HCA exposure. However, the viability of quantifying HCAs following hydrolytic release from adducts in vivo and correlation with dietary intake are unproven. To definitively assess the potential of labile HCA-protein ...
... BACKGROUND: Bacopa monnieri is a medicinal plant which has long been used in Ayurvedic medicines to augment brain function and to improve memory. The purpose of our study was to identify and evaluate possible toxic effects of B. monnieri extract in rats by assessing hematological, biochemical, and histopathological parameters. METHODS: Acute oral toxicity of Bacopa monnieri extract was studied in ...
... Mycotoxins in food are increasingly a food safety hazard concern in particular in developing countries. This study was performed to determine the occurrence and determinants of aflatoxin and fumonisin contamination in rice and maize and to assess health risks through dietary intake exposure among ethnic minority groups in northern Vietnam. A total of 111 rice and 102 maize samples, were tested for ...
... Aluminium was measured in 2580 samples of 15 food groups and dietary exposure was estimated. Samples were purchased and analysed during 2010 to 2014. High aluminium levels were found in jellyfish (mean 4862 mg/kg), laver (mean 455.2 mg/kg) and fried twisted cruller (mean 392.4 mg/kg). Dietary exposure to aluminium was estimated for Zhejiang residents. The average dietary exposure to aluminium via ...
... The study reports the results of testing the sensitivity of an early warning sampling plan for detecting milk batches with high aflatoxin AFM ₁ concentration. The effectiveness of the method was investigated by the analysis of 9017 milk samples collected in Italian milk processing plants that applied control plans with different action limits (AL). For those milk processing plants where 30 ng kg ⁻ ...
Cissus quadrangularis; acute toxicity; biomarkers; body weight; death; diclofenac; dietary exposure; drugs; edema; endothelium; ethanol; hemorrhage; histopathology; median effective concentration; medicinal plants; pain; patients; phenylephrine; poisoning; quality control; rats; subchronic toxicity; toxicity testing; traditional medicine
Abstract:
... Cissus quadrangularis L. is a medicinal plant widely used in Thai traditional medicine, especially to alleviate hemorrhoids. The aim of the present study was to investigate acute oral toxicity, anti-inflammatory and venoconstrictive effects of a whole plant standardized ethanol extract from C. quadrangularis in rats, followed by the evaluation of safety and efficacy of enteric film coated tablets ...
... Meadowsweet (Filipendula ulmaria (L.) Maxim.), and dropwort (Filipendula vulgaris Moench) flowers are traditionally used to treat various ailments, including inflammatory conditions. The aim of the present study was to validate the aforementioned ethnomedicinal claim by assessing antihyperalgesic and antiedematous activities and toxicity of orally administered lyophilized flower infusions (LFIs) o ...
J.C. Escalona-Arranz; R. Perez-Rosés; J. Rodríguez-Amado; H.J. Morris-Quevedo; L.B. Mwasi; O. Cabrera-Sotomayor; R. Machado-García; O. Fong-Lórez; A. Alfonso-Castillo; E. Puente-Zapata
... In the scientific community, there is a growing interest in Tamarindus indica L. leaves, both as a valuable nutrient and as a functional food. This paper focuses on exploring its safety and antioxidant properties. A tamarind leaf fluid extract (TFE) wholly characterised was evaluated for its anti-DPPH activity (IC ₅₀ = 44.36 μg/mL) and its reducing power activity (IC ₅₀ = 60.87 μg/mL). TFE also ex ...
Monte Carlo method; Procambarus clarkii; arsenic; bioavailability; cadmium; copper; crayfish; dietary exposure; fish; human health; humans; lead; models; nickel; probabilistic risk assessment; risk; risk estimate; safety standards; selenium; zinc; China; Sweden; United States
Abstract:
... Freshwater crayfish, the world's third largest crustacean species, has been reported to accumulate high levels of metals, while the current knowledge of potential risk associated with crayfish consumption lags behind that of finfish. We provide the first estimate of human health risk associated with crayfish (Procambarus clarkii) consumption in China, the world's largest producer and consumer of c ...
World Health Organization; anthropogenic activities; arsenic; average daily intake; cadmium; chromium; cobalt; copper; dietary exposure; drinking water; groundwater; guidelines; health effects assessments; health hazards; ingestion; lead; manganese; nickel; people; principal component analysis; rice; risk; vegetables; wheat; zinc; India
Abstract:
... This study investigates the level of contamination and health risk assessment for arsenic (As) and other elements in drinking water, vegetables and other food components in two blocks (Mohiuddinagar and Mohanpur) from the Samastipur district, Bihar, India. Groundwater (80%) samples exceeded the World Health Organization (WHO) guideline value (10μg/L) of As while Mn exceeded the previous WHO limit ...
... Soil developed on mineralised bedrock areas of the Sierra de Aracena Natural Park (SW Spain) is geochemically characterised by naturally high levels of heavy metals and metalloids (notably Zn, Pb, Ag and Cd, but also As, Sb, Cu and Tl). To assess environmental availability, geochemical speciation and potential health risk of such geogenic trace elements, 24 randomly selected soil samples were subj ...
adverse effects; body weight; dietary exposure; fillets; fish; fish consumption; human health; humans; perfluorooctane sulfonic acid; perfluorooctanoic acid; pollutants; seafoods; Italy
Abstract:
... Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are pollutants of anthropic origin with possible side effects on human health. Diet, and in particular fish and seafood, is considered the major intake pathway for humans. The present study investigated the levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) contamination in twenty-five samples of fresh fillet of five w ...
... The main purpose of the present study is to assess human dietary exposure to essential and non-essential trace elements via consumption of selected homegrown foodstuffs. Twelve essential and non-essential trace elements (Cd, Co, Cu, Cr, Hg, Mo, Ni, Pb, Sb, Se, Zn and As) were detected in various homegrown foodstuffs. Detailed questionnaires were also applied among a sample of the local population ...
Ángel Rodríguez-Hernández; María Camacho; Luis A. Henríquez-Hernández; Luis D. Boada; Norberto Ruiz-Suárez; Pilar F. Valerón; Maira Almeida González; Annalisa Zaccaroni; Manuel Zumbado; Octavio P. Luzardo
Cephalopoda; acute toxicity; additive effect; adults; arsenic; benzo(a)pyrene; cadmium; carcinogenicity; chemical concentration; children; dietary exposure; fish; fish consumption; fish products; health hazards; hexachlorobenzene; human health; mercury; normal values; organochlorine pesticides; pollutants; polychlorinated biphenyls; polycyclic aromatic hydrocarbons; risk; risk communication; seafoods; supermarkets; toxic substances; Canary Islands; Spain
Abstract:
... In this work we have evaluated the potential carcinogenic and acutely toxic risks associated to the exposure to highly prevalent organic and inorganic contaminants through the consumption of fishery products by the Spanish population. The concentrations of 8 organochlorine pesticides (OCPs), 18 polychlorinated biphenils (PCBs), 7 polycyclic aromatic hydrocarbons (expressed as benzo[a]pyrene toxic ...
Mediterranean diet; beverages; bottles; breakfast; cans; dietary exposure; endocrine system; endocrine-disrupting chemicals; food packaging; fruit juices; growth and development; nutritional adequacy; school children; toxicology; vegetables; Spain
Abstract:
... Young children, whose growth and development are highly dependent on the endocrine system, are particularly vulnerable to endocrine disruptor exposure. The main objectives of this study were to measure BPA migration levels from cans, fruit juice bottles/packs, and microwave containers used for food/drinks consumed by a sample of 6- to 8-year old schoolchildren in Spain and to estimate the relation ...
... Mercury is a metal naturally present in the environment with concentrations in aquatic systems increasing annually due to human activities. This represents a great concern mainly due to its high toxicity to organisms and consequences for human health. Most studies regarding the toxic effect of mercury have focussed on freshwater species using water as the exposure and uptake pathway. In contrast, ...
... The present study was aimed at determining bioaccumulation and cell and tissue distribution of Pb and Cd in the green garden snail, Cantareus apertus (Born, 1778), exposed to different nominal dietary concentrations of Pb (25, 100 and 2500mgPb/kg), Cd (5, 10 and 100mgCd/kg) and their combination (25mg Pb+10mgCd/kg and 2500mg Pb+100mgCd/kg) for 1 and 8wk. Pb and Cd were bioaccumulated in the digest ...
... There is growing concern about methylmercury (MeHg) accumulation in rice grains and thus enhanced dietary exposure to MeHg in Asian countries. Here, we explored the possibility of reducing grain MeHg levels by biochar amendment, and the underlying mechanisms. Pot (i.e., rice cultivation in biochar amended soils) and batch experiments (i.e., incubation of amended soils under laboratory conditions) ...
... This study evaluates the in vitro anti-snake venom potential of Peristrophe bivalvis (PB) extracts against Naja kaouthia (NK) and Trimeresurus albolabris (TA) venoms, including inhibition of cytotoxic effects and enzymatic activities, and the binding-precipitation of extracts and venom proteins analysis. In addition, the antioxidant, cytotoxic and in vivo acute oral toxic activities of PB extracts ...
cadmium; correlation; dietary exposure; exposure assessment; peanuts; protein content; risk; soil; China
Abstract:
... Cadmium (Cd) in 8698 peanut samples collected from China in 2009–2014 was studied to evaluate its contamination level, distribution, and health risk. The average Cd concentration was 0.1684 mg kg–1; the range of 2.5–97.5% was 0.0191–0.4762 mg kg–1, indicating the cadmium-contaminated peanut level was even lower. Some peanut strains for which protein contents had a significant correlation (Pearson ...
Manfred Beckmann; Annemiek M. Joosen; Michelle M. Clarke; Owen Mugridge; Gary Frost; Barbara Engel; Kathleen Taillart; Amanda J. Lloyd; John Draper; John K. Lodge
acute exposure; biomarkers; blood; body mass index; correlation; dietary exposure; fasting; fatty acids; females; fructose; humans; ketone bodies; metabolome; metabolomics; public health; sucrose; urine
Abstract:
... SCOPE: The intake of sucrose is of public health concern but limited information is available on the metabolic effects of short‐term exposure. Our aim was to use metabolomics to investigate the metabolic impact of acute sucrose exposure. METHODS AND RESULTS: We performed a randomized, parallel, single‐dose feeding study on healthy females (n = 90, aged 29.9 ± 4.7 years, BMI 23.3 ± 2.5 kg/m²) consu ...
... The gavage route is often used for the toxicological evaluation of food contaminants. This route does not take into account absorption of the toxicants through the buccal mucosa, as evidenced in dogs for bisphenol A (BPA). Our goal was to determine the functional significance of buccal BPA absorption during dietary exposure. Four ewes received BPA by nasogastric gavage (100 mg/kg) and through food ...
... The chemical composition of three edible seaweeds (Codium capitatum, Hypnea spicifera and Sargassum elegans) and two inedible seaweeds (Halimeda cuneata and Spyridia hypnoides) from the Indian Ocean along the KwaZulu-Natal East Coast, South Africa were investigated as a function of seasonal variation. The proximate compositions of the edible seaweeds were determined. In edible seaweeds, the moistu ...
adolescents; antibiotic residues; average daily intake; body weight; chloramphenicol; dairy industry; dietary exposure; elderly; enzyme-linked immunosorbent assay; laws and regulations; milk; raw milk; Brazil
Abstract:
... Antibiotic residues in products of animal origin are of great concern to regulatory agencies and consumers worldwide. Indiscriminate use of antibiotics has promoted the development of bacterial resistance, which has become an international issue. The occurrence of chloramphenicol (CAP) was evaluated in 84 raw milk samples from the reception platform of a dairy industry at Northern Parana, Brazil a ...
... Dietary exposure to pesticide residues may present a risk to public health, especially for sensitive populations such as pregnant women. To characterize this risk, this study assessed chronic dietary exposure to pesticide residues based on the French ELFE cohort. A self-administered food frequency questionnaire (FFQ) about the last three months of pregnancy filled in by pregnant women in 2011 was ...
... Poor dietary exposure disproportionately affects African-Americans and contributes to the persistence of disparities in health outcomes. In this study, we hypothesized that fortified dietary intervention (FDI) will improve measured dietary and related health outcomes and will be acceptable among low-income African-American women living in Tampa, FL. These objectives were tested using a prospective ...
... Transformation of rice with genes encoding insecticidal Cry proteins from Bacillus thuringiensis (Bt) should confer high resistance to target lepidopteran pests, such as Chilo suppressalis, and low toxicity to non-target organisms, such as silkworm Bombyx mori. Five purified Cry proteins that have been used for plant transformation were tested using dietary exposure assays. The susceptibility of C ...
... Various methods are available for estimating usual dietary intake distributions. Hence, there is a need for simulation studies to compare them. The methods Iowa State University (ISU), National Cancer Institute (NCI), Multiple Source Method (MSM) and Statistical Program to Assess Dietary Exposure (SPADE) were previously compared in another study, but some results were inconclusive due to the small ...
... European methods for assessing dietary exposures to nutrients, additives and other substances in food are limited by the availability of detailed food consumption data for all member states. A proposed comprehensive European dietary exposure model (CEDEM) applies summary data published by the European Food Safety Authority (EFSA) in a deterministic model based on an algorithm from the EFSA intake ...
Monte Carlo method; adolescents; adults; anthracenes; benzo(a)pyrene; children; dietary exposure; fried foods; gas chromatography-mass spectrometry; neoplasms; oils; risk; risk estimate; China
Abstract:
... Youtiao, or oil stick, is a typical, traditional and widely-consumed fried food in China. The concentration of polycyclic aromatic hydrocarbons (PAHs) in youtiao from different origins was determined. The dietary exposure and cancer risk associated with benzo[a]pyrene equivalents from youtiao consumption were estimated using Monte Carlo simulation. Analysis of 16 PAHs in youtiao was completed by g ...