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... Washing of iceberg lettuce with HOCl solutions in concentrations ranging from 1.41 to 141mg/L resulted in 0.69 to 2.05μg3-chlorotyrosine/g vegetable. As also six commercial ready-to-eat iceberg lettuces from different producers contained 3-chlorotyrosine from 1.00 to 2.24μg/g vegetable, a total of 122 ready-to-eat vegetable samples purchased in Belgian supermarkets were further screened for their ...
... Application of manure, biosolids, and recycled wastewater to croplands could be a potential pathway through which trace organic compounds (TOrCs) may be taken up by food crops. We present a framework to prepare a short list of TOrCs for detailed risk assessment and evaluation in terms of bioaccumulation. The framework was modified from Lipinski’s method to predict drug permeability based on four c ...
... Quantitative Structure Activity Relationship (QSAR) models are expected to play an important role in the risk assessment of chemicals on humans and the environment. In this study, we developed a validated QSAR model to predict acute oral toxicity of 329 pesticides to rats because a few QSAR models have been devoted to predict the Lethal Dose 50 (LD50) of pesticides on rats. This QSAR model is base ...
... As an essential element, selenium (Se) is beneficial at low levels yet toxic at high levels. The present study assessed the effects of dietary exposure to Se in the least killifish Heterandria formosa, and investigated how this exposure influences the effects of a subsequent exposure to cadmium (Cd). The fish were pre-exposed to an environmentally relevant concentration (2 μg g−1 dry wt) of dietar ...
... A mycotoxin-dedicated total diet study (mTDS) allowing assessment of occurrence and dietary exposure to these substances was developed and carried out in the Netherlands in 2013. First, literature was searched to establish the occurrence profile of mycotoxins. Next, foods as consumed according to the Dutch National Food Consumption Surveys (DNFCS) for young children and persons aged 7-69 years, ca ...
Pituophis; Thomomys talpoides; active ingredients; adults; basins; burrows; cropland; demographic statistics; diet; dietary exposure; females; geographic information systems; gophers; habitats; land cover; models; neurotoxins; orchards; poisoning; population density; population size; risk; rodenticides; snakes; strychnine; vineyards; British Columbia
Abstract:
... Strychnine is a neurotoxin and an active ingredient in some rodenticides which are placed in burrows to suppress pocket gopher (Thomomys talpoides) populations in range and crop land in western North America. The population level impact was modelled of the use of strychnine-based rodenticides on a non-target snake species, the Great Basin Gophersnake (Pituophis catenifer deserticola), which is a p ...
... Alcohol intake has been associated with preventive as well as negative effects on health. However, the intake estimates are often based on subjective reporting and therefore biased and the types of beverages consumed are often inaccurately reported. Accurate and specific quantification of alcohol related compounds in biological samples may help to understand dietary exposure and metabolic kinetics ...
average daily intake; dietary exposure; fish; fish consumption; freshwater; ingestion; neoplasms; nutrition assessment; polychlorinated biphenyls; risk; socioeconomics; toxicity; India
Abstract:
... The objective of this study is to determine the concentrations of polychlorinated biphenyls (PCBs) in different fish species collected from fish outlets in the south Indian city of Hyderabad. The samples of fish extracted by using Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) and concentrations of polychlorinated biphenyls (PCBs, 45 congeners) were determined by gas chromatography–mic ...
... Indospicine (l-2-amino-6-amidinohexanoic acid) is a natural hepatotoxin found in all parts of some Indigofera plants such as Indigofera linnaei and Indigofera spicata. Several studies have documented a susceptibility to this hepatotoxin in different species of animals, including cattle, sheep, dogs, and rats, which are associated with mild to severe liver disease after prolonged ingestion. However ...
... Heterocyclic aromatic amines (HCA) are carcinogenic mutagens formed during cooking of protein-rich foods. HCA residues adducted to blood proteins have been postulated as biomarkers of HCA exposure. However, the viability of quantifying HCAs following hydrolytic release from adducts in vivo and correlation with dietary intake are unproven. To definitively assess the potential of labile HCA-protein ...
acrylamides; body weight; coffee (beverage); dietary exposure; ferrocyanides; formic acid; issues and policy; lowest observed effect level; methanol; no observed adverse effect level; potassium; public health; risk; risk assessment; risk communicators; stakeholders; vending machines; zinc acetate
Abstract:
... The present study aimed to evaluate the levels of acrylamide in coffee brews acquired from coffee vending machines. Acrylamide content ranged from 7.7 to 40.0μg/L (mean: 20.6μg/L). These levels are similar to those found in coffee brews prepared by other coffee machines with different extraction procedures. The dietary exposure of the Spanish population to acrylamide through coffee drinks was esti ...
... BACKGROUND: Bacopa monnieri is a medicinal plant which has long been used in Ayurvedic medicines to augment brain function and to improve memory. The purpose of our study was to identify and evaluate possible toxic effects of B. monnieri extract in rats by assessing hematological, biochemical, and histopathological parameters. METHODS: Acute oral toxicity of Bacopa monnieri extract was studied in ...
... The sub-acute toxicity of E. faecalis HZNU P2 was investigated in rats fed with different doses for 14 days. To evaluate the acute oral toxicity of E. faecalis HZNU P2, rats were fed with E. faecalis HZNU P2 at a high dose of 2×10 ¹¹ CFU kg ⁻¹ for 10 days. Results showed that there were no abnormal clinical signs in any of the groups during the experiment. There were no significant differences in ...
... In the present study, a total of 358 samples consisting of raw milk of cow (n = 64), goat (n = 56) and sheep (n = 52); traditional cheese (n = 40), yoghurt (n = 42), Kashk (n = 40), Doogh (n = 44) and Tarkhineh (n = 20) were analyzed for aflatoxin M1 (AFM1) by using an enzyme linked immunosorbent assay (ELISA). Frequency of AFM1 and its concentration ranges in the ELISA positive samples were deter ...
... Mycotoxins in food are increasingly a food safety hazard concern in particular in developing countries. This study was performed to determine the occurrence and determinants of aflatoxin and fumonisin contamination in rice and maize and to assess health risks through dietary intake exposure among ethnic minority groups in northern Vietnam. A total of 111 rice and 102 maize samples, were tested for ...
... Aluminium was measured in 2580 samples of 15 food groups and dietary exposure was estimated. Samples were purchased and analysed during 2010 to 2014. High aluminium levels were found in jellyfish (mean 4862 mg/kg), laver (mean 455.2 mg/kg) and fried twisted cruller (mean 392.4 mg/kg). Dietary exposure to aluminium was estimated for Zhejiang residents. The average dietary exposure to aluminium via ...
... Glyphosate is a herbicide used to control broad-leaved weeds. Some uses of glyphosate in crop production can lead to residues of the active substance and related metabolites in food. This paper uses data on residue levels, processing information and consumption patterns, to assess theoretical lifetime dietary exposure to glyphosate.Initial estimates were made assuming exposure to the highest permi ...
... The study reports the results of testing the sensitivity of an early warning sampling plan for detecting milk batches with high aflatoxin AFM ₁ concentration. The effectiveness of the method was investigated by the analysis of 9017 milk samples collected in Italian milk processing plants that applied control plans with different action limits (AL). For those milk processing plants where 30 ng kg ⁻ ...
Western diets; advanced glycation end products; butter; canned meat; databases; dietary exposure; food choices; food matrix; fruits; grain products; human health; lysine; tandem mass spectrometry; ultra-performance liquid chromatography; vegetables
Abstract:
... The aim of this study was to validate an ultra-performance liquid chromatography tandem mass-spectrometry (UPLC–MS/MS) method for the determination of advanced glycation endproducts (AGEs) in food items and to analyze AGEs in a selection of food items commonly consumed in a Western diet. Nε-(carboxymethyl)lysine (CML), Nε-(1-carboxyethyl)lysine (CEL) and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-orn ...
Cissus quadrangularis; acute toxicity; biomarkers; body weight; death; diclofenac; dietary exposure; drugs; edema; endothelium; ethanol; hemorrhage; histopathology; median effective concentration; medicinal plants; pain; patients; phenylephrine; poisoning; quality control; rats; subchronic toxicity; toxicity testing; traditional medicine
Abstract:
... Cissus quadrangularis L. is a medicinal plant widely used in Thai traditional medicine, especially to alleviate hemorrhoids. The aim of the present study was to investigate acute oral toxicity, anti-inflammatory and venoconstrictive effects of a whole plant standardized ethanol extract from C. quadrangularis in rats, followed by the evaluation of safety and efficacy of enteric film coated tablets ...
... Meadowsweet (Filipendula ulmaria (L.) Maxim.), and dropwort (Filipendula vulgaris Moench) flowers are traditionally used to treat various ailments, including inflammatory conditions. The aim of the present study was to validate the aforementioned ethnomedicinal claim by assessing antihyperalgesic and antiedematous activities and toxicity of orally administered lyophilized flower infusions (LFIs) o ...
J.C. Escalona-Arranz; R. Perez-Rosés; J. Rodríguez-Amado; H.J. Morris-Quevedo; L.B. Mwasi; O. Cabrera-Sotomayor; R. Machado-García; O. Fong-Lórez; A. Alfonso-Castillo; E. Puente-Zapata
... In the scientific community, there is a growing interest in Tamarindus indica L. leaves, both as a valuable nutrient and as a functional food. This paper focuses on exploring its safety and antioxidant properties. A tamarind leaf fluid extract (TFE) wholly characterised was evaluated for its anti-DPPH activity (IC ₅₀ = 44.36 μg/mL) and its reducing power activity (IC ₅₀ = 60.87 μg/mL). TFE also ex ...
animals; cellulose; chemical bonding; chlorides; cotton fabric; dietary exposure; durability; irradiation; laundry; multiple drug resistance; polymerization; public health; skin irritation; toxicity testing
Abstract:
... Multidrug-resistant superbugs are currently a severe threat to public health. Here, we report a novel kind of antisuperbug material prepared by irradiation induced graft polymerization of 1-butyl-3-vinyl imidazole chloride onto cotton fabric. The reduction of superbugs on this fabric is higher than 99.9%. Attributed to the strong covalent bonding between the graft chains and the cellulose macromol ...
Monte Carlo method; Procambarus clarkii; arsenic; bioavailability; cadmium; copper; crayfish; dietary exposure; fish; human health; humans; lead; models; nickel; probabilistic risk assessment; risk; risk estimate; safety standards; selenium; zinc; China; Sweden; United States
Abstract:
... Freshwater crayfish, the world's third largest crustacean species, has been reported to accumulate high levels of metals, while the current knowledge of potential risk associated with crayfish consumption lags behind that of finfish. We provide the first estimate of human health risk associated with crayfish (Procambarus clarkii) consumption in China, the world's largest producer and consumer of c ...
World Health Organization; anthropogenic activities; arsenic; average daily intake; cadmium; chromium; cobalt; copper; dietary exposure; drinking water; groundwater; guidelines; health effects assessments; health hazards; ingestion; lead; manganese; nickel; people; principal component analysis; rice; risk; vegetables; wheat; zinc; India
Abstract:
... This study investigates the level of contamination and health risk assessment for arsenic (As) and other elements in drinking water, vegetables and other food components in two blocks (Mohiuddinagar and Mohanpur) from the Samastipur district, Bihar, India. Groundwater (80%) samples exceeded the World Health Organization (WHO) guideline value (10μg/L) of As while Mn exceeded the previous WHO limit ...
... Soil developed on mineralised bedrock areas of the Sierra de Aracena Natural Park (SW Spain) is geochemically characterised by naturally high levels of heavy metals and metalloids (notably Zn, Pb, Ag and Cd, but also As, Sb, Cu and Tl). To assess environmental availability, geochemical speciation and potential health risk of such geogenic trace elements, 24 randomly selected soil samples were subj ...
adverse effects; body weight; dietary exposure; fillets; fish; fish consumption; human health; humans; perfluorooctane sulfonic acid; perfluorooctanoic acid; pollutants; seafoods; Italy
Abstract:
... Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are pollutants of anthropic origin with possible side effects on human health. Diet, and in particular fish and seafood, is considered the major intake pathway for humans. The present study investigated the levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) contamination in twenty-five samples of fresh fillet of five w ...
... The main purpose of the present study is to assess human dietary exposure to essential and non-essential trace elements via consumption of selected homegrown foodstuffs. Twelve essential and non-essential trace elements (Cd, Co, Cu, Cr, Hg, Mo, Ni, Pb, Sb, Se, Zn and As) were detected in various homegrown foodstuffs. Detailed questionnaires were also applied among a sample of the local population ...
Ángel Rodríguez-Hernández; María Camacho; Luis A. Henríquez-Hernández; Luis D. Boada; Norberto Ruiz-Suárez; Pilar F. Valerón; Maira Almeida González; Annalisa Zaccaroni; Manuel Zumbado; Octavio P. Luzardo
Cephalopoda; acute toxicity; additive effect; adults; arsenic; benzo(a)pyrene; cadmium; carcinogenicity; chemical concentration; children; dietary exposure; fish; fish consumption; fish products; health hazards; hexachlorobenzene; human health; mercury; normal values; organochlorine pesticides; pollutants; polychlorinated biphenyls; polycyclic aromatic hydrocarbons; risk; risk communication; seafoods; supermarkets; toxic substances; Canary Islands; Spain
Abstract:
... In this work we have evaluated the potential carcinogenic and acutely toxic risks associated to the exposure to highly prevalent organic and inorganic contaminants through the consumption of fishery products by the Spanish population. The concentrations of 8 organochlorine pesticides (OCPs), 18 polychlorinated biphenils (PCBs), 7 polycyclic aromatic hydrocarbons (expressed as benzo[a]pyrene toxic ...
Mediterranean diet; beverages; bottles; breakfast; cans; dietary exposure; endocrine system; endocrine-disrupting chemicals; food packaging; fruit juices; growth and development; nutritional adequacy; school children; toxicology; vegetables; Spain
Abstract:
... Young children, whose growth and development are highly dependent on the endocrine system, are particularly vulnerable to endocrine disruptor exposure. The main objectives of this study were to measure BPA migration levels from cans, fruit juice bottles/packs, and microwave containers used for food/drinks consumed by a sample of 6- to 8-year old schoolchildren in Spain and to estimate the relation ...
... Mercury is a metal naturally present in the environment with concentrations in aquatic systems increasing annually due to human activities. This represents a great concern mainly due to its high toxicity to organisms and consequences for human health. Most studies regarding the toxic effect of mercury have focussed on freshwater species using water as the exposure and uptake pathway. In contrast, ...
... Consumption of vegetables grown in arsenic (As)-contaminated soils is an important exposure route to the element for humans. The present study is focused on locally-grown, frequently-consumed vegetables, such as carrots (Daucus carota), beets (Beta vulgaris) and quinoa (Chenopodium) from the As-polluted Chiu Chiu area in Northern Chile. The latter region is affected both by As discharge from coppe ...
... The present study was aimed at determining bioaccumulation and cell and tissue distribution of Pb and Cd in the green garden snail, Cantareus apertus (Born, 1778), exposed to different nominal dietary concentrations of Pb (25, 100 and 2500mgPb/kg), Cd (5, 10 and 100mgCd/kg) and their combination (25mg Pb+10mgCd/kg and 2500mg Pb+100mgCd/kg) for 1 and 8wk. Pb and Cd were bioaccumulated in the digest ...
Copepoda; phytoplankton; bioaccumulation; phenanthrenes; anthracenes; marine ecosystems; dietary exposure; solvents; Rhodomonas; water uptake; keystone species; zooplankton; gas chromatography-mass spectrometry
Abstract:
... Laboratory exposure experiments were performed on the marine coastal zooplankton species Pseudodiaptomus marinus—a keystone species of vast Atlantic and Pacific marine ecosystems, tracing the accumulation of three polycyclic aromatic hydrocarbons (PAHs): phenanthrene, anthracene and pyrene. The experiment was designed to study the bioconcentration of PAHs in phytoplankton (Rhodomonas baltica) and ...
Bowen Du; Samuel P. Haddad; Andreas Luek; W. Casan Scott; Gavin N. Saari; S. Rebekah Burket; Christopher S. Breed; Martin Kelly; Linda Broach; Joseph B. Rasmussen; C. Kevin Chambliss; Bryan W. Brooks
... Though pharmaceuticals and other contaminants of emerging concern are increasingly observed in inland water bodies, the occurrence and bioaccumulation of pharmaceuticals in estuaries and coastal ecosystems are poorly understood. In the present study, bioaccumulation of select pharmaceuticals and other contaminants of emerging concern was examined in fish from Buffalo Bayou, a tidally influenced ur ...
heavy metals; lead; urban areas; dietary exposure; urbanization; risk; bioavailability; cadmium; human health; risk assessment; industrialization; cities; point source pollution; health effects assessments; United States Environmental Protection Agency; humans; models; developing countries; soil; chromium; traffic; food intake; therapeutics; industrial effluents; nickel; vegetables; environmental monitoring
Abstract:
... A verity of human activities i.e. urbanization and industrialization have been resulted serious environmental contaminations by heavy metals in all over the world. The settlement of populations in urban and nearby industrial areas for economic development has significant share in their exposure to these metallic contaminants. Depending on the nature and type of the pollutants, targeted urban-indus ...
... There is growing concern about methylmercury (MeHg) accumulation in rice grains and thus enhanced dietary exposure to MeHg in Asian countries. Here, we explored the possibility of reducing grain MeHg levels by biochar amendment, and the underlying mechanisms. Pot (i.e., rice cultivation in biochar amended soils) and batch experiments (i.e., incubation of amended soils under laboratory conditions) ...
... This study evaluates the in vitro anti-snake venom potential of Peristrophe bivalvis (PB) extracts against Naja kaouthia (NK) and Trimeresurus albolabris (TA) venoms, including inhibition of cytotoxic effects and enzymatic activities, and the binding-precipitation of extracts and venom proteins analysis. In addition, the antioxidant, cytotoxic and in vivo acute oral toxic activities of PB extracts ...
... Acrylamide (AA) is a process-contaminant that potentially increases the risk of developing cancer in humans. AA is formed during heat treatment of starchy foods and detected in a wide range of commonly consumed products. Increased focus on risk ranking and prioritization of major causes of disease makes it relevant to estimate the impact that exposure to chemical contaminants and other hazards in ...
cadmium; correlation; dietary exposure; exposure assessment; peanuts; protein content; risk; soil; China
Abstract:
... Cadmium (Cd) in 8698 peanut samples collected from China in 2009–2014 was studied to evaluate its contamination level, distribution, and health risk. The average Cd concentration was 0.1684 mg kg–1; the range of 2.5–97.5% was 0.0191–0.4762 mg kg–1, indicating the cadmium-contaminated peanut level was even lower. Some peanut strains for which protein contents had a significant correlation (Pearson ...
Manfred Beckmann; Annemiek M. Joosen; Michelle M. Clarke; Owen Mugridge; Gary Frost; Barbara Engel; Kathleen Taillart; Amanda J. Lloyd; John Draper; John K. Lodge
acute exposure; biomarkers; blood; body mass index; correlation; dietary exposure; fasting; fatty acids; females; fructose; humans; ketone bodies; metabolome; metabolomics; public health; sucrose; urine
Abstract:
... SCOPE: The intake of sucrose is of public health concern but limited information is available on the metabolic effects of short‐term exposure. Our aim was to use metabolomics to investigate the metabolic impact of acute sucrose exposure. METHODS AND RESULTS: We performed a randomized, parallel, single‐dose feeding study on healthy females (n = 90, aged 29.9 ± 4.7 years, BMI 23.3 ± 2.5 kg/m²) consu ...
... The gavage route is often used for the toxicological evaluation of food contaminants. This route does not take into account absorption of the toxicants through the buccal mucosa, as evidenced in dogs for bisphenol A (BPA). Our goal was to determine the functional significance of buccal BPA absorption during dietary exposure. Four ewes received BPA by nasogastric gavage (100 mg/kg) and through food ...
... The chemical composition of three edible seaweeds (Codium capitatum, Hypnea spicifera and Sargassum elegans) and two inedible seaweeds (Halimeda cuneata and Spyridia hypnoides) from the Indian Ocean along the KwaZulu-Natal East Coast, South Africa were investigated as a function of seasonal variation. The proximate compositions of the edible seaweeds were determined. In edible seaweeds, the moistu ...
adolescents; antibiotic residues; average daily intake; body weight; chloramphenicol; dairy industry; dietary exposure; elderly; enzyme-linked immunosorbent assay; laws and regulations; milk; raw milk; Brazil
Abstract:
... Antibiotic residues in products of animal origin are of great concern to regulatory agencies and consumers worldwide. Indiscriminate use of antibiotics has promoted the development of bacterial resistance, which has become an international issue. The occurrence of chloramphenicol (CAP) was evaluated in 84 raw milk samples from the reception platform of a dairy industry at Northern Parana, Brazil a ...
... In the present study, the chronic cumulative exposure to organophosphorus (OPs), carbamates (CBs) and pyrethroid and pyrethrin (PPs) pesticides in the region of Valencia through fruit and vegetables consumption is presented. A total of 752 samples and 84 pesticides were studied of which, 52 were OPs, 23 CBs and 9 PPs. Residue data were derived from the Valencia Region monitoring program 2007–2011 ...
... Dietary exposure to pesticide residues may present a risk to public health, especially for sensitive populations such as pregnant women. To characterize this risk, this study assessed chronic dietary exposure to pesticide residues based on the French ELFE cohort. A self-administered food frequency questionnaire (FFQ) about the last three months of pregnancy filled in by pregnant women in 2011 was ...
American Indians; Veneroida; adults; algae; beaches; children; cognition; diet; dietary exposure; domoic acid; humans; long term effects; longevity; longitudinal studies; risk; toxicity
Abstract:
... The CoASTAL cohort represents the first community cohort assembled to study a HAB-related illness. It is comprised of three Native American tribes in the Pacific NW for the purpose of studying the health impacts of chronic, low level domoic acid (DA) exposure through razor clam consumption. This cohort is at risk of DA toxicity by virtue of their geographic location (access to beaches with a histo ...
... Poor dietary exposure disproportionately affects African-Americans and contributes to the persistence of disparities in health outcomes. In this study, we hypothesized that fortified dietary intervention (FDI) will improve measured dietary and related health outcomes and will be acceptable among low-income African-American women living in Tampa, FL. These objectives were tested using a prospective ...
... Transformation of rice with genes encoding insecticidal Cry proteins from Bacillus thuringiensis (Bt) should confer high resistance to target lepidopteran pests, such as Chilo suppressalis, and low toxicity to non-target organisms, such as silkworm Bombyx mori. Five purified Cry proteins that have been used for plant transformation were tested using dietary exposure assays. The susceptibility of C ...
... Various methods are available for estimating usual dietary intake distributions. Hence, there is a need for simulation studies to compare them. The methods Iowa State University (ISU), National Cancer Institute (NCI), Multiple Source Method (MSM) and Statistical Program to Assess Dietary Exposure (SPADE) were previously compared in another study, but some results were inconclusive due to the small ...