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- Author:
- Song, Yufeng, et al. ; Xie, Yanqi; Yang, Junjiao; Li, Ruiqiong; Jin, Xu; Yang, Jing; Show all 6 Authors
- Source:
- Journal of materials chemistry B 2016 v.4 no.40 pp. 6588-6596
- ISSN:
- 2050-7518
- Subject:
- antineoplastic activity; apoptosis; aqueous solutions; ascorbic acid; biocompatibility; breast neoplasms; cell lines; drugs; flow cytometry; nanoparticles; neoplasm cells; paclitaxel; polyethylene glycol; synergism; therapeutics; toxicity testing
- Abstract:
- ... Despite progress, the combination therapy of a nanoscale delivery system and its loaded drug to increase the efficiency of anticancer treatment still remains a challenge. In this study, taking advantage of ascorbic acid with anticancer activity, complex nanovehicles were designed and constructed by co-assembly of the amphiphilic block polymers poly(ascorbyl acrylate)-block-poly(lactic acid) (PAA-b ...
- DOI:
- 10.1039/c6tb01818a
-
http://dx.doi.org/10.1039/c6tb01818a
- Author:
- Yao, YuFeng, et al. ; Zhang, Qiufen; Wan, Baoshan; Zhou, Aiping; Ni, Jinjing; Xu, Zhihong; Li, Shuxian; Tao, Jing; Show all 8 Authors
- Source:
- Gene 2016 v.582 no.2 pp. 128-136
- ISSN:
- 0378-1119
- Subject:
- Mycobacterium tuberculosis; drugs; genotype; isoniazid; multiple drug resistance; nucleotide sequences; operon; pathogens; sequence analysis; single nucleotide polymorphism; tuberculosis; virulence; China
- Abstract:
- ... Mycobacterium tuberculosis (M.tb) is one of the most prevalent bacterial pathogens in the world. With geographical wide spread and hypervirulence, Beijing/W family is the most successful M.tb lineage. China is a country of high tuberculosis (TB) and high multiple drug-resistant TB (MDR-TB) burden, and the Beijing/W family strains take the largest share of MDR strains. To study the genetic basis of ...
- DOI:
- 10.1016/j.gene.2016.02.003
-
https://dx.doi.org/10.1016/j.gene.2016.02.003
- Author:
- Li, Yufeng, et al. ; Zheng, Li; Wang, Dan; Zhang, Xiang; Li, Jia; Ali, Sher; Lu, Jingze; Zong, Hao; Xu, Xiaolan; Show all 9 Authors
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 534-538
- ISSN:
- 0006-291X
- Subject:
- AMP-activated protein kinase; agonists; aminopeptidases; bioactive properties; blood glucose; diabetes; drugs; fluorescence; fluorescent dyes; glucose; glucose transporters; glycemic control; insulin; plasma membrane; staurosporine
- Abstract:
- ... Insulin-stimulated GLUT4 translocation from GLUT4 storage vesicles (GSVs) to the plasma membrane (PM) constitutes a key process for blood glucose control. Therefore, compounds that could promote GLUT4 translocation into the PM represent potential drugs for the treatment of diabetes. In this research, we screened for agonists that induce GLUT4 translocation by using a novel pH-sensitive fluorescent ...
- DOI:
- 10.1016/j.bbrc.2016.10.056
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.056
- Author:
- Chen, Yufeng, et al. ; Yang, Libin; Gong, Mengdi; Jiang, Xin; Han, Xiaoxia; Song, Kun; Sun, Xiaodong; Zhang, Yingjiu; Zhao, Bing; Show all 9 Authors
- Source:
- Colloids and surfaces 2016 v.508 pp. 142-149
- ISSN:
- 0927-7757
- Subject:
- adsorption; detection limit; drugs; levofloxacin; nanoparticles; pH; semiconductors; titanium dioxide; zinc
- Abstract:
- ... In this work, TiO2 and Zn doped TiO2 nanoparticles (Zn-TiO2 NPs) were synthesized and served as SERS-active substrate for the detection of levofloxacin (LVFX) drug molecules. Both experimental and theoretical methods are used to study the enhanced mechanism and interaction between substrate and drug molecule. The results indicate that the LVFX is close to the substrate surface through the carboxyl ...
- DOI:
- 10.1016/j.colsurfa.2016.08.068
-
https://dx.doi.org/10.1016/j.colsurfa.2016.08.068
- Author:
- Jiang, Yufeng, et al. ; Xing, Guoqiang; Wang, Bo; Lei, Ying; Liu, Chunli; Wang, Zhuo; Shi, Hongjuan; Yang, Rentan; Qin, Wenjuan; Lv, Hailong; Show all 10 Authors
- Source:
- Molecular and biochemical parasitology 2016 v.207 pp. 49-55
- ISSN:
- 0166-6851
- Subject:
- Echinococcus granulosus; adverse effects; benzimidazole; carbamates; caspase-3; colorimetry; droplets; drug therapy; drugs; echinococcosis; lipids; mortality; protoscoleces; scanning electron microscopy; sodium arsenite; staining; surgery; tissues; transmission electron microscopy; vacuoles; viability; zoonoses
- Abstract:
- ... Cystic echinococcosis (CE) caused by the metacestodes of Echinococcus granulosus is an important cosmopolitan zoonosis. Surgery is the main treatment option for CE. Meanwhile, chemotherapy is used as an significant adjunct to surgery. However, the benzimidazole carbamate group and the existing scolicidal agents may not be as effective as hoped. In this study, we aimed to explore the in vitro effec ...
- DOI:
- 10.1016/j.molbiopara.2016.05.011
-
http://dx.doi.org/10.1016/j.molbiopara.2016.05.011
- Author:
- Chen, Yufeng, et al. ; Xie, Maobin; Fan, Dejun; Zhao, Zheng; He, Xiaowen; Li, Gang; Chen, Aizheng; Wu, Xiaojian; Li, Jiashen; Li, Zhi; Hunt, John A.; Li, Yi; Lan, Ping; Show all 13 Authors
- Source:
- Biomaterials 2016 v.103 pp. 33-43
- ISSN:
- 0142-9612
- Subject:
- adverse effects; curcumin; drug delivery systems; drug therapy; drugs; fibroins; growth retardation; interphase; nanofibers; neoplasms; silk; tissues; toxicity
- Abstract:
- ... The development of more effective cancer therapeutic strategies are still critically required. The maximization of the therapeutic effect in combination with avoiding the severe side effects on normal tissues when using chemotherapy drugs is still an urgent problem that requires improvements urgently. Here we provide implantable and controllable drug-release that utilises silk fibroin (SF) as a na ...
- DOI:
- 10.1016/j.biomaterials.2016.06.049
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.049