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1. Functional Characterization of a Marine Bacillus Esterase and its Utilization in the Stereo-Selective Production of D-Methyl Lactate

Author:
Hu, Yunfeng,   et al.   ; Huang, Jinlong; Zhang, Yun;     Show all 3 Authors
Source:
Applied biochemistry and biotechnology 2016 v.180 no.8 pp. 1467-1481
ISSN:
0273-2289
Subject:
drugs; esterases; fermentation; heptane; industry; lactic acid; value added; Indian Ocean
Abstract:
... Chiral lactic acid and its ester derivatives are crucial building blocks and platforms in the generation of high value-added drugs, fine chemicals and functional materials. Optically pure D-lactic acid and its ester derivatives cannot be directly generated from fermentation and are quite expensive. Herein, we identified, heterologously expressed and functionally characterized one Bacillus esterase ...
DOI:
10.1007/s12010-016-2180-y

2. Functional Characterization of a Novel Dactylosporangium Esterase and Its Utilization in the Asymmetric Synthesis of (R)-Methyl Mandelate

Author:
Hu, Yunfeng,   et al.   ; Deng, Dun; Zhang, Yun; Sun, Aijun;     Show all 4 Authors
Source:
Applied biochemistry and biotechnology 2016 v.180 no.2 pp. 228-247
ISSN:
0273-2289
Subject:
Dactylosporangium aurantiacum; drugs; esterases; genome; pH
Abstract:
... One novel esterase DAEst6 was identified from the genome of Dactylosporangium aurantiacum subsp. Hamdenensis NRRL 18085. DAEst6 was further characterized to be an esterase which exhibited high resistance to high pH values. Esterase DAEst6 could resolve racemic methyl mandelate and generate (R)-methyl mandelate, one key drug intermediate, with an enantiomeric excess and a conversion of 99 and 49 %, ...
DOI:
10.1007/s12010-016-2095-7

3. Optimal dosing regimen of biapenem in Chinese patients with lower respiratory tract infections based on population pharmacokinetic/pharmacodynamic modelling and Monte Carlo simulation

Author:
Zhao, Yunfeng,   et al.   ; Dong, Jing; Xiong, Wei; Chen, Yuancheng; Lu, Yang; Zhao, Di; Li, Wenyan; Liu, Yanhui; Chen, Xijing;     Show all 9 Authors
Source:
International journal of antimicrobial agents 2016 v.47 no.3 pp. 202-209
ISSN:
0924-8579
Subject:
Acinetobacter baumannii; Monte Carlo method; Pseudomonas aeruginosa; antibiotics; bacteria; creatinine; drugs; models; pathogens; patients; pharmacodynamics; pharmacokinetics; probability; respiratory tract diseases; therapeutics
Abstract:
... In this study, a population pharmacokinetic (PPK) model of biapenem in Chinese patients with lower respiratory tract infections (LRTIs) was developed and optimal dosage regimens based on Monte Carlo simulation were proposed. A total of 297 plasma samples from 124 Chinese patients were assayed chromatographically in a prospective, single-centre, open-label study, and pharmacokinetic parameters were ...
DOI:
10.1016/j.ijantimicag.2015.12.018

4. Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent

Author:
Shen, Yunfeng,   et al.   ; Cheng, Feng; Wang, Lingling; Xia, Jun; Chen, Heng; Jiang, Yuanqiang; Lu, Mize;     Show all 7 Authors
Source:
Biochemical and biophysical research communications 2016 v.470 pp. 324-330
ISSN:
0006-291X
Subject:
antineoplastic activity; apoptosis; cytotoxicity; drugs; genes; humans; mice; models; mononuclear leukocytes; myeloid leukemia; oral administration; severe combined immunodeficiency; stem cells
Abstract:
... Mammalian target of rapamycin (mTOR) as a potential drug target for treatment of acute myeloid leukemia (AML). Here, we investigated the potential anti-leukemic activity by WYE-687, a potent mTOR kinase inhibitor. We demonstrated that WYE-687 potently inhibited survival and proliferation of established (HL-60, U937, AML-193 and THP-1 lines) and human AML progenitor cells. Yet, same WYE-687 treatme ...
DOI:
10.1016/j.bbrc.2016.01.054