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- Ko, Ju-Young; Kang, Nalae; Lee, Ji-Hyeok; Kim, Jin-Soo; Kim, Won-Suck; Park, Sun-Joo; Kim, Yong-Tae; Jeon, You-Jin
- Process biochemistry 2016 v.51 no.4 pp. 535-541
- Paralichthys olivaceus, etc ; angiotensin I; angiotensin-converting enzyme inhibitors; animal disease models; antihypertensive effect; blood pressure; flounder; functional foods; gel chromatography; hydrolysates; hypertension; inhibitory concentration 50; molecular models; muscles; pepsin; peptidyl-dipeptidase A; proteolysis; rats; reversed-phase high performance liquid chromatography; ultrafiltration; Show all 20 Subjects
- ... The aim of this study was to purify peptides with anti-hypertensive properties from a hydrolysate of flounder fish muscle. Among four proteolytic hydrolysates, pepsin showed the strongest angiotensin-I converting enzyme (ACE) inhibitory activity. The pepsin hydrolysate was fractionated by ultrafiltration, gel filtration chromatography and reverse-phase high performance liquid chromatography, and t ...