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- Kandil, Rima, et al. Show all 9 Authors
- Journal of controlled release 2016 v.244 pp. 269-279
- cell lines; dissociation; drugs; encapsulation; endocytosis; flow cytometry; fluorescein; folate receptors; folic acid; gene expression; hydrodynamics; hydrogels; ligands; macrophages; mice; micelles; plasmids; polymers; rheumatoid arthritis; therapeutics; transfection; zeta potential
- ... New folic acid (FA) coupled three layered micelles (3LM) were designed to encapsulate DNA, and their application as delivery system that specifically targets activated macrophages was investigated for new treatment options in rheumatoid arthritis (RA). FA coupled poly(l-lactide)-b-poly(ethylene glycol) (FA-PEG-PLLA) was synthesized via the NHS-ester activated/amine coupling method. Fluorescein lab ...