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- Patil, Nitin A.; Bathgate, Ross A. D.; Kocan, Martina; Ang, Sheng Yu; Tailhades, Julien; Separovic, Frances; Summers, Roger; Grosse, Johannes; Hughes, Richard A.; Wade, John D.; Hossain, Mohammed Akhter
- Amino acids 2016 v.48 no.4 pp. 987-992
- G-protein coupled receptors, etc ; acids; amides; anorexia; colon; disulfide bonds; drugs; electrostatic interactions; food intake; humans; obesity; peptides; relaxin; Show all 13 Subjects
- ... Insulin-like peptide 5 (INSL5) is an orexigenic peptide hormone belonging to the relaxin family of peptides. It is expressed primarily in the L-cells of the colon and has a postulated key role in regulating food intake. Its G protein-coupled receptor, RXFP4, is a potential drug target for treating obesity and anorexia. We studied the effect of modification of the C-terminus of the A and B-chains o ...