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- Compadre, Cesar M., et al. Show all 9 Authors
- Journal of natural products 2016 v.79 no.4 pp. 691-696
- cytotoxicity; humans; lethal dose 50; mechanism of action; mononuclear leukocytes; myeloid leukemia; neoplasm cells; patients; sesquiterpenoid lactones; traditional medicine; Ecuador
- ... The sesquiterpene lactones dehydroleucodine (1) and leucodine (2) were isolated from Gynoxys verrucosa, a species used in traditional medicine in southern Ecuador. The activity of these compounds was determined against eight acute myeloid leukemia (AML) cell lines and compared with their activity against normal peripheral blood mononuclear cells. Compound 1 showed cytotoxic activity against the te ...