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1. Designing Ga(iii)-containing hydroxyapatite with antibacterial activity

Author:
Kurtjak, Mario; Vukomanović, Marija; Krajnc, Andraž; Kramer, Lovro; Turk, Boris; Suvorov, Danilo
Source:
RSC advances 2016 v.6 no.114 pp. 112839-112852
ISSN:
2046-2069
Subject:
biocompatibility,   etc   ; antibacterial properties; calcium; cytotoxicity; fibroblasts; gallium; hydroxyapatite; ions; mice; nanocrystals;     Show all 10 Subjects
Abstract:
... Modified hydroxyapatite with antibacterial properties and high biocompatibility with mammalian cells is very desirable in many biomedical applications. Here we study the incorporation of Ga³⁺ ions into hydroxyapatite to achieve such an effective biological response. Antibacterial action against P. aeruginosa and cytocompatibility with L929 mouse fibroblasts was examined in vitro for different hydr ...
DOI:
10.1039/c6ra23424k

2. Melanin nanoparticles as an endogenous agent for efficient iron overload therapy

Author:
YanThese authors contributed equally., Junjie; Ji, Yu; Zhang, Pengjun; Lu, Xiaomei; Fan, Quli; Pan, Donghui; Yang, Runlin; Xu, Yuping; Wang, Lizhen; Zhang, Lei; Yang, Min
Source:
Journal of materials chemistry B 2016 v.4 no.45 pp. 7233-7240
ISSN:
2050-7518
Subject:
biocompatibility,   etc   ; adverse effects; biodegradability; chelating agents; deferoxamine; drugs; iron; iron overload; melanin; mice; nanoparticles; therapeutics;     Show all 12 Subjects
Abstract:
... Improving iron-chelating drugs for the safe and efficient therapy of iron overload disease is greatly challenging and highly desired. Endogenous iron chelators are perfect candidates because of their intrinsic biodegradability and biocompatibility, which avoid the severe side effects of the exogenous drugs currently present in clinical applications. Herein, for the first time, we have reported sim ...
DOI:
10.1039/c6tb01558a

3. Temperature responsive porous silicon nanoparticles for cancer therapy – spatiotemporal triggering through infrared and radiofrequency electromagnetic heating

Author:
Tamarov, Konstantin; Xu, Wujun; Osminkina, Liubov; Zinovyev, Sergey; Soininen, Pasi; Kudryavtsev, Andrey; Gongalsky, Maxim; Gaydarova, Azha; Närvänen, Ale; Timoshenko, Victor; Lehto, Vesa-Pekka
Source:
Journal of Controlled Release 2016 v.241 pp. 220-228
ISSN:
0168-3659
Subject:
biocompatibility,   etc   ; carcinoma; cell death; coatings; doxorubicin; encapsulation; lung neoplasms; mice; models; nanoparticles; polymers; silicon; temperature; therapeutics;     Show all 14 Subjects
Abstract:
... One critical functionality of the carrier system utilized in targeted drug delivery is its ability to trigger the release of the therapeutic cargo once the carrier has reached its target. External triggering is an alluring approach as it can be applied in a precise spatiotemporal manner. In the present study, we achieved external triggering through the porous silicon (PSi) nanoparticles (NPs) by p ...
DOI:
10.1016/j.jconrel.2016.09.028

4. CaCO3/Tetraethylenepentamine–Graphene Hollow Microspheres as Biocompatible Bone Drug Carriers for Controlled Release

Author:
Li, Jie; Jiang, Hongkun; Ouyang, Xiao; Han, Shihui; Wang, Jun; Xie, Rui; Zhu, Wenting; Ma, Ning; Wei, Hao; Jiang, Zhongyi
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.44 pp. 30027-30036
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; bones; calcium carbonate; corals; cytotoxicity; doxorubicin; drug carriers; humans; mice; mineralization; osteosarcoma; pH;     Show all 12 Subjects
Abstract:
... CaCO₃ is one kind of important biological mineral, which widely exists in coral, shell, and other organisms. Since it is similar to bone tissue elements and has good biocompatibility, it was very suitable as a candidates for bone drug carriers. In this work, we used tetraethylenepentamine–graphene (rGO-TEPA) sheet matrices induction of CaCO₃ mineralization and successfully constructed CaCO₃/rGO-TE ...
DOI:
10.1021/acsami.6b10697

5. Near-Infrared Organic Dye-Based Nanoagent for the Photothermal Therapy of Cancer

Author:
Zhou, Bingjiang; Li, Yunzheng; Niu, Guangle; Lan, Minhuan; Jia, Qingyan; Liang, Qionglin
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.44 pp. 29899-29905
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; absorption; bovine serum albumin; dyes; fluorescence; mice; nanoparticles; neoplasms; therapeutics; toxicity;     Show all 10 Subjects
Abstract:
... Given their easy structural modification and good biocompatibility advantages, near-infrared (NIR) organic dyes with a large molar extinction coefficient, while a superlow fluorescence quantum yield shows considerable potential application in photothermal therapy (PTT). Herein, a new NIR-absorbing asymmetric cyanine dye, namely, RC, is designed and synthesized via the hybrid of rhodamine and hemic ...
DOI:
10.1021/acsami.6b07838

6. Epineurium-mimicking chitosan conduits for peripheral nervous tissue engineering

Author:
Nawrotek, Katarzyna; Tylman, Michał; Rudnicka, Karolina; Gatkowska, Justyna; Wieczorek, Marek
Source:
Carbohydrate polymers 2016 v.152 pp. 119-128
ISSN:
0144-8617
Subject:
biocompatibility,   etc   ; additives; animal models; chitosan; collagen; hyaluronic acid; mice; molecular weight; nerve tissue; tissue engineering;     Show all 10 Subjects
Abstract:
... In this investigation, we report on a fabrication method of epineurium-mimicking tubular conduits based on electrodeposition from chitosan solution. The pre-enrichment of electrodeposition solution with hyaluronic acid and/or collagen components results in structures which structural, morphological, and physicochemical properties can be controlled. In order to determine the optimal composition of ...
DOI:
10.1016/j.carbpol.2016.07.002

7. Impact of Covalent Functionalization on the Aqueous Processability, Catalytic Activity, and Biocompatibility of Chemically Exfoliated MoS2 Nanosheets

Author:
Paredes, Juan I.; Munuera, José M.; Villar-Rodil, Silvia; Guardia, Laura; Ayán-Varela, Miguel; Pagán, Ana; Aznar-Cervantes, Salvador D.; Cenis, José L.; Martínez-Alonso, Amelia; Tascón, Juan M. D.
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.41 pp. 27974-27986
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; acetic acid; annealing; catalytic activity; cell proliferation; derivatization; fibroblasts; mice; nanosheets; nanosilver;     Show all 10 Subjects
Abstract:
... Chemically exfoliated MoS₂ (ce-MoS₂) has emerged in recent years as an attractive two-dimensional material for use in relevant technological applications, but fully exploiting its potential and versatility will most probably require the deployment of appropriate chemical modification strategies. Here, we demonstrate that extensive covalent functionalization of ce-MoS₂ nanosheets with acetic acid g ...
DOI:
10.1021/acsami.6b08444

8. Redoxable heteronanocrystals functioning magnetic relaxation switch for activatable T1 and T2 dual-mode magnetic resonance imaging

Author:
Kim, Myeong-Hoon; Son, Hye-Young; Kim, Ga-Yun; Park, Kwangyeol; Huh, Yong-Min; Haam, Seungjoo
Source:
Biomaterials 2016 v.101 pp. 121-130
ISSN:
0142-9612
Subject:
biocompatibility,   etc   ; biomarkers; glutathione; hydrodynamics; image analysis; ions; magnetic resonance imaging; magnetite; manganese; mice; polysorbates; protons;     Show all 12 Subjects
Abstract:
... T1/T2 dual-mode magnetic resonance (MR) contrast agents (DMCAs) have gained much attention because of their ability to improve accuracy by providing two pieces of complementary information with one instrument. However, most of these agents are “always ON” systems that emit MR contrast regardless of their interaction with target cells or biomarkers, which may result in poor target-to-background rat ...
DOI:
10.1016/j.biomaterials.2016.05.054

9. Synthesis and optimization of ZnPc-loaded biocompatible nanoparticles for efficient photodynamic therapy

Author:
Ping, Jian-tao; Peng, Hong-shang; Duan, Wu-biao; You, Fang-tian; Song, Min; Wang, Yi-quan
Source:
Journal of materials chemistry B 2016 v.4 no.25 pp. 4482-4489
ISSN:
2050-7518
Subject:
biocompatibility,   etc   ; chemical bonding; mice; nanocarriers; nanoparticles; photochemotherapy; photosensitizing agents; polymers; singlet oxygen;     Show all 9 Subjects
Abstract:
... Zinc(ii) phthalocyanine (ZnPc) is a promising photosensitizer for PDT but suffers from aggregation in a physiological aqueous environment. In this paper, a class of biocompatible polymeric nanoparticles (NPs) was prepared to encapsulate ZnPc molecules. Mostly because of the planar structure, ZnPc molecules were difficult to be encapsulated into the polymeric NPs unless further coated with a thick ...
DOI:
10.1039/c6tb00307a

10. AIE-Active Tetraphenylethylene Cross-Linked N-Isopropylacrylamide Polymer: A Long-Term Fluorescent Cellular Tracker

Author:
Ma, Hengchang; Qi, Chunxuan; Cheng, Chao; Yang, Zengming; Cao, Haiying; Yang, Zhiwang; Tong, Jinhui; Yao, Xiaoqiang; Lei, Ziqiang
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.13 pp. 8341-8348
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; adenocarcinoma; cell transplantation; crosslinking; fibroblasts; fluorescence; humans; hydrophilicity; hydrophobicity; mice; polymers; staining; temperature; tracer techniques;     Show all 14 Subjects
Abstract:
... There is a great demand to understand cell transplantation, migration, division, fusion, and lysis. Correspondingly, illuminant object-labeled bioprobes have been employed as long-term cellular tracers, which could provide valuable insights into detecting these biological processes. In this work, we designed and synthesized a fluorescent polymer, which was comprised of hydrophilic N-isopropylacryl ...
DOI:
10.1021/acsami.5b11091

11. A New Polymer Nanoprobe Based on Chemiluminescence Resonance Energy Transfer for Ultrasensitive Imaging of Intrinsic Superoxide Anion in Mice

Author:
Li, Ping; Liu, Lu; Xiao, Haibin; Zhang, Wei; Wang, Lulin; Tang, Bo
Source:
Journal of the American Chemical Society 2016 v.138 no.9 pp. 2893-2896
ISSN:
1520-5126
Subject:
biocompatibility,   etc   ; chemiluminescence; energy transfer; image analysis; mice; polymers; superoxide anion; tissues;     Show all 8 Subjects
Abstract:
... Despite significant developments in optical imaging of superoxide anion (O₂•–) as the preliminary reactive oxygen species, novel visualizing strategies that offer ultrahigh sensitivity are still imperative. This is mainly because intrinsic concentrations of O₂•– are extremely low in living systems. Herein, we present the rational design and construction of a new polymer nanoprobe PCLA-O₂•– for det ...
DOI:
10.1021/jacs.5b11784

12. Near-Infrared Light Activation of Proteins Inside Living Cells Enabled by Carbon Nanotube-Mediated Intracellular Delivery

Author:
Li, He; Fan, Xinqi; Chen, Xing
Source:
ACS applied materials 2016 v.8 no.7 pp. 4500-4507
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; carbon; carbon nanotubes; green fluorescent protein; mice; nanocarriers; neoplasms; wavelengths;     Show all 8 Subjects
Abstract:
... Light-responsive proteins have been delivered into the cells for controlling intracellular events with high spatial and temporal resolution. However, the choice of wavelength is limited to the UV and visible range; activation of proteins inside the cells using near-infrared (NIR) light, which has better tissue penetration and biocompatibility, remains elusive. Here, we report the development of a ...
DOI:
10.1021/acsami.6b00323

13. Bioabsorbable cellulose composites prepared by an improved mineral-binding process for bone defect repair

Author:
Hu, Yang; Zhu, Yongjun; Zhou, Xin; Ruan, Changshun; Pan, Haobo; Catchmark, Jeffrey M.
Source:
Journal of materials chemistry B 2016 v.4 no.7 pp. 1235-1246
ISSN:
2050-7518
Subject:
biocompatibility,   etc   ; biodegradation; biomineralization; body fluids; cell culture; cellulases; cellulose; glucose; hydroxyapatite; mice; osteoblasts;     Show all 11 Subjects
Abstract:
... Bioabsorbable bacterial cellulose composites were prepared separately by immersing bacterial cellulose (BC) in different simulated body fluids (SBF) followed by incorporating cellulase enzymes into BC. The biomineralization of BC in SBF has been intensively documented and generally involves a tedious preparation. This study revealed an improved approach to disperse hydroxyapatite (HA) nanopowder t ...
DOI:
10.1039/c5tb02091c

14. Characterization and biocompatibility of injectable microspheres-loaded hydrogel for methotrexate delivery

Author:
Dang, Qifeng; Liu, Chengsheng; Wang, Yujie; Yan, Jingquan; Wan, Huiqin; Fan, Bing
Source:
Carbohydrate polymers 2016 v.136 pp. 516-526
ISSN:
0144-8617
Subject:
biocompatibility,   etc   ; drug delivery systems; gelatinization temperature; gelation; hydrocolloids; methotrexate; mice; viscosity;     Show all 8 Subjects
Abstract:
... Injectable thermosensitive hydrogels have widely been studied as drug delivery systems for their minimally invasive administration and localized drug release. However, burst drug release limits clinical applications of such hydrogels. A double-component injectable formulation (microspheres-loaded hydrogel, CMs-CS-HG) was thus fabricated to eliminate the limitation. Gelation temperature, gelation t ...
DOI:
10.1016/j.carbpol.2015.09.084

15. 3D printing of biomaterials with mussel-inspired nanostructures for tumor therapy and tissue regeneration

Author:
Ma, Hongshi; Luo, Jian; Sun, Zhe; Xia, Lunguo; Shi, Mengchao; Liu, Mingyao; Chang, Jiang; Wu, Chengtie
Source:
Biomaterials 2016 v.111 pp. 138-148
ISSN:
0142-9612
Subject:
biocompatibility,   etc   ; biocompatible materials; biodegradability; bones; cell death; mice; nanomaterials; neoplasm cells; neoplasms; patients; rabbits; stem cells; surgery; tissue repair;     Show all 14 Subjects
Abstract:
... Primary bone cancer brings patients great sufferings. To deal with the bone defects resulted from cancer surgery, biomaterials with good bone-forming ability are necessary to repair bone defects. Meanwhile, in order to prevent possible tumor recurrence, it is essential that the remaining tumor cells around bone defects are completely killed. However, there are few biomaterials with the ability of ...
DOI:
10.1016/j.biomaterials.2016.10.005

16. Hexagonal boron nitride nanoplates as emerging biological nanovectors and their potential applications in biomedicine

Author:
Lu, Tun; Wang, Libo; Jiang, Ye; liu, Qiuwen; Huang, Caijin
Source:
Journal of materials chemistry B 2016 v.4 no.36 pp. 6103-6110
ISSN:
2050-7518
Subject:
biocompatibility,   etc   ; adjuvants; antibodies; antigens; apoptosis; boron nitride; bovine serum albumin; crosslinking; cytotoxicity; immunization; medicine; mice; nanoparticles; vaccines; water solubility;     Show all 15 Subjects
Abstract:
... The application of nanomaterials in the biological and medical areas has attracted great attention. Cytotoxicity, stability and solubility are the prerequisites for a nanomaterial to be considered for application in the field of biomedicine. Here, we suggest a simple method to produce highly dispersed water-soluble ultrathin h-BN nanoplates whose size measures ca. 30–60 nm in diameter and 1.6 nm i ...
DOI:
10.1039/c6tb01481j

17. Epidermal growth factor loaded heparin-based hydrogel sheet for skin wound healing

Author:
Goh, MeeiChyn; Hwang, Youngmin; Tae, Giyoong
Source:
Carbohydrate polymers 2016 v.147 pp. 251-260
ISSN:
0144-8617
Subject:
biocompatibility,   etc   ; epidermal growth factor; ethylene glycol; granulation tissue; heparin; humans; hydrocolloids; mice; polyethylene glycol; polymerization; tissue repair;     Show all 11 Subjects
Abstract:
... A heparin-based hydrogel sheet composed of thiolated heparin and diacrylated poly (ethylene glycol) was prepared via photo polymerization and human epidermal growth factor (hEGF) were loaded into it for the purpose of wound healing. It showed a sustained release profile of hEGF in vitro. In order to evaluate its function on wound healing in vivo, full thickness wounds were created on the dorsal su ...
DOI:
10.1016/j.carbpol.2016.03.072

18. Degradation pattern of porous CaCO3 and hydroxyapatite microspheres in vitro and in vivo for potential application in bone tissue engineering B Biointerfaces

Author:
Zhong, Qiwei; Li, Wenhua; Su, Xiuping; Li, Geng; Zhou, Ying; Kundu, Subhas C.; Yao, Juming; Cai, Yurong
Source:
Colloids and surfaces 2016 v.143 pp. 56-63
ISSN:
0927-7765
Subject:
biocompatibility,   etc   ; biodegradation; bone formation; bones; calcium carbonate; colloids; hydroxyapatite; inflammation; mice; pH; sericin; silk; sodium alginate; tissue engineering; weight loss;     Show all 15 Subjects
Abstract:
... Despite superior clinical handling, excellent biocompatibility, biodegradation property of calcium phosphate needs to be improved to coincide with the rate of new bone formation. In this study, spherical CaCO3 are fabricated in the presence of the silk sericin and then transformed into porous hydroxyapatite (HAP) microspheres via hydrothermal method. The degradation behavior of obtained CaCO3, HAP ...
DOI:
10.1016/j.colsurfb.2016.03.020

19. Synthesis and Characterization of Water-Soluble Conjugated Oligoelectrolytes for Near-Infrared Fluorescence Biological Imaging

Author:
Woo, Shin-Jae; Park, Sungmin; Jeong, Ji-Eun; Hong, Yoochan; Ku, Minhee; Kim, Bo Yun; Jang, Il Ho; Heo, Soon Chul; Wang, Taejun; Kim, Ki Hean; Yang, Jaemoon; Kim, Jae Ho; Woo, Han Young
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.25 pp. 15937-15947
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; ammonium; ethylene oxide; fluorenes; fluorescence; fluorescent dyes; image analysis; mice; microscopy; models; neoplasms; photoluminescence; sodium; thiophene; water solubility; wavelengths;     Show all 16 Subjects
Abstract:
... Near-infrared (NIR) fluorophores attract increasing attention as a molecular marker (or probe) for in vivo and in vitro biological fluorescence imaging. Three types of new NIR fluorescent conjugated oligoelectrolytes (COEs: Q-FlTBTTFl, Q-FlBBTFl, and Q-FlTBBTTFl) are synthesized with quaternized ammonium ionic groups in their side-chains for water solubility. The emission wavelength is modulated i ...
DOI:
10.1021/acsami.6b04276

20. Comparative repair capacity of knee osteochondral defects using regenerated silk fiber scaffolds and fibrin glue with/without autologous chondrocytes during 36 weeks in rabbit model

Author:
Kazemnejad, Somaieh; Khanmohammadi, Manijeh; Mobini, Sahba; Taghizadeh-Jahed, Masoud; Khanjani, Sayeh; Arasteh, Shaghayegh; Golshahi, Hannaneh; Torkaman, Giti; Ravanbod, Roya; Heidari-Vala, Hamed; Moshiri, Ali; Tahmasebi, Mohammad-Naghi; Akhondi, Mohammad-Mehdi
Source:
Cell and tissue research 2016 v.364 no.3 pp. 559-572
ISSN:
0302-766X
Subject:
biocompatibility,   etc   ; Bombyx mori; cartilage; chondrocytes; clinical trials; fibrin; histopathology; in vivo studies; knees; mechanical properties; mice; models; porosity; rabbits; silk;     Show all 15 Subjects
Abstract:
... The reconstruction capability of osteochondral (OCD) defects using silk-based scaffolds has been demonstrated in a few studies. However, improvement in the mechanical properties of natural scaffolds is still challengeable. Here, we investigate the in vivo repair capacity of OCD defects using a novel Bombyx mori silk-based composite scaffold with great mechanical properties and porosity during 36 w ...
DOI:
10.1007/s00441-015-2355-9

21. One-pot solventless preparation of PEGylated black phosphorus nanoparticles for photoacoustic imaging and photothermal therapy of cancer

Author:
Sun, Caixia; Wen, Ling; Zeng, Jianfeng; Wang, Yong; Sun, Qiao; Deng, Lijuan; Zhao, Chongjun; Li, Zhen
Source:
Biomaterials 2016 v.91 pp. 81-89
ISSN:
0142-9612
Subject:
biocompatibility,   etc   ; energy; heat; image analysis; irradiation; mice; milling; nanoparticles; nanosheets; neoplasm cells; neoplasms; permeability; phosphorus; photostability; therapeutics;     Show all 15 Subjects
Abstract:
... Black phosphorus (BP) nanostructures such as nanosheets and nanoparticles have attracted considerable attention in recent years due to their unique properties and great potential in various physical, chemical, and biological fields. In this article, water-soluble and biocompatible PEGylated BP nanoparticles with a high yield were prepared by one-pot solventless high energy mechanical milling techn ...
DOI:
10.1016/j.biomaterials.2016.03.022

22. Biocompatible Hollow Polydopamine Nanoparticles Loaded Ionic Liquid Enhanced Tumor Microwave Thermal Ablation in Vivo

Author:
Tan, Longfei; Tang, Wenting; Liu, Tianlong; Ren, Xiangling; Fu, Changhui; Liu, Bo; Ren, Jun; Meng, Xianwei
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.18 pp. 11237-11245
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; nanogold; microwave radiation; acute toxicity; intravenous injection; neoplasms; cytotoxicity; antineoplastic activity; nanocomposites; mice; irradiation; ionic liquids; blood; nanoparticles;     Show all 14 Subjects
Abstract:
... Tumor microwave thermal therapy (MWTT) has attracted more attention because of the minimal damage to body function, convenient manipulation and low complications. Herein, a novel polydopamine (PDA) nanoparticle loading ionic liquids (ILs/PDA) as microwave susceptible agent is introduced for enhancing the selectivity and targeting of MWTT. ILs/PDA nanocomposites have an excellent microwave heating ...
DOI:
10.1021/acsami.5b12329

23. Tubelike Gold Sphere–Attapulgite Nanocomposites with a High Photothermal Conversion Ability in the Near-Infrared Region for Enhanced Cancer Photothermal Therapy

Author:
Wu, Ping; Deng, Dan; Gao, Jingwen; Cai, Chenxin
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.16 pp. 10243-10252
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; harvesting; gold; nanospheres; energy; neoplasms; absorption; heat; nanocomposites; nanorods; therapeutics; mice; regrowth; photons; surface plasmon resonance;     Show all 15 Subjects
Abstract:
... Near-infrared (NIR)-induced photothermal therapy (PTT) is now considered to be a promising and highly efficient method for tumor therapy. Photothermal agents play a crucial role in PTT, and they are required to possess the ability to harvest NIR light and transform the photon energy into heat energy. This work reports a facile method to synthesize a new PTT agent, which is based on the electrostat ...
DOI:
10.1021/acsami.6b02270

24. Microwave-assisted one-step rapid synthesis of near-infrared gold nanoclusters for NIRF/CT dual-modal bioimaging

Author:
Liu, Yang; Tian, Gao-Fei; He, Xi-Wen; Li, Wen-You; Zhang, Yu-Kui
Source:
Journal of materials chemistry B 2016 v.4 no.7 pp. 1276-1283
ISSN:
2050-7518
Subject:
biocompatibility,   etc   ; computed tomography; cytotoxicity; fluorescence; folic acid; image analysis; irradiation; mice; microwave treatment; nanogold; neoplasm cells; neoplasms; ultraviolet radiation;     Show all 13 Subjects
Abstract:
... The development of ideal contrast agents was of great importance for multimodal imaging. However, the simple combination of different contrast components always needed long-time preparation and a tough reaction environment. In this study, we introduced a one-step microwave-assisted approach to synthesize lysozyme-capped gold nanoclusters (Lys–Au NCs) rapidly instead of traditional conditions. Irra ...
DOI:
10.1039/c5tb02322j

25. Facile synthesis of novel albumin-functionalized flower-like MoS₂ nanoparticles for in vitro chemo-photothermal synergistic therapy

Author:
Chen, Liang; Feng, Wei; Zhou, Xiaojun; Qiu, Kexin; Miao, Yingke; Zhang, Qianqian; Qin, Ming; Li, Lei; Zhang, Yanzhong; He, Chuanglong
Source:
RSC advances 2016 v.6 no.16 pp. 13040-13049
ISSN:
2046-2069
Subject:
biocompatibility,   etc   ; bovine serum albumin; breast neoplasms; cytotoxicity; doxorubicin; drug therapy; hemolysis; hydrazine; mice; molybdenum disulfide; nanoparticles; neoplasm cells; photothermotherapy;     Show all 13 Subjects
Abstract:
... Synergistic therapy, the combination of photothermal therapy and chemotherapy, has been becoming an attractive strategy to circumvent certain drawbacks in current cancer chemotherapy. Herein, a synergistic therapeutic nanoplatform based on novel albumin functionalized flower-like MoS₂ spherical nanoparticles was reported. The MoS₂ nanoparticles were prepared by using hydrazine hydrate as both redu ...
DOI:
10.1039/c5ra27822h

26. One-pot synthesis of gadolinium-doped carbon quantum dots for high-performance multimodal bioimaging

Author:
PanThese authors contributed equally to this work., Yi; Yang, Jun; Fang, Yaning; Zheng, Junhui; Song, Rong; Yi, Changqing
Source:
Journal of materials chemistry B 2016 v.5 no.1 pp. 92-101
ISSN:
2050-7518
Subject:
biocompatibility,   etc   ; biomedical research; blood vessels; carbon quantum dots; coatings; fluorescence; gadolinium; image analysis; mice; models; pyrolysis; surgery; synthesis; temperature; water solubility;     Show all 15 Subjects
Abstract:
... In this study, an efficient and mild approach is reported for the facile synthesis of a carbon quantum dot (CQD)-based dual-modal fluorescence (FL)/magnetic resonance (MR) imaging probe by doping Gd(iii) into CQDs through a one-pot pyrolysis process at low temperature. The as-prepared Gd-encapsulated CQDs (GCDs), which have an average diameter of ∼15 nm, are highly water-soluble. The GCDs are obse ...
DOI:
10.1039/c6tb02115h

27. In vitro potency, in vitro and in vivo efficacy of liposomal alendronate in combination with γδ T cell immunotherapy in mice

Author:
Hodgins, Naomi O.; Al-Jamal, Wafa' T.; Wang, Julie T-W.; Parente-Pereira, Ana C.; Liu, Mao; Maher, John; Al-Jamal, Khuloud T.
Source:
Journal of Controlled Release 2016 v.241 pp. 229-241
ISSN:
0168-3659
Subject:
biocompatibility,   etc   ; T-lymphocytes; animal models; animal ovaries; caudal vein; cell viability; clinical trials; death; excretion; immunotherapy; intraperitoneal injection; intravenous injection; melanoma; mice; ovarian neoplasms;     Show all 15 Subjects
Abstract:
... Nitrogen-containing bisphosphonates (N-BP), including zoledronic acid (ZOL) and alendronate (ALD), have been proposed as sensitisers in γδ T cell immunotherapy in pre-clinical and clinical studies. Therapeutic efficacy of N-BPs is hampered by their rapid renal excretion and high affinity for bone. Liposomal formulations of N-BP have been proposed to improve accumulation in solid tumours. Liposomal ...
DOI:
10.1016/j.jconrel.2016.09.023
PubMed:
27664328
PubMed Central:
PMC5073077

28. Temoporfin-loaded 1-tetradecanol-based thermoresponsive solid lipid nanoparticles for photodynamic therapy

Author:
Brezaniova, Ingrid; Hruby, Martin; Kralova, Jarmila; Kral, Vladimir; Cernochova, Zulfiya; Cernoch, Peter; Slouf, Miroslav; Kredatusova, Jana; Stepanek, Petr
Source:
Journal of Controlled Release 2016 v.241 pp. 34-44
ISSN:
0168-3659
Subject:
biocompatibility,   etc   ; adenocarcinoma; antineoplastic activity; biodegradability; drug delivery systems; humans; in vitro studies; lipids; mice; nanoparticles; neoplasm cells; particle size; phototoxicity; polymers;     Show all 14 Subjects
Abstract:
... We developed fully biodegradable/metabolizable nanosystem based on polymer surfactant-stabilized thermoresponsive solid lipid nanoparticles with non-covalently bound photosensitizer temoporfin (T-SLNP) with particle size below 50nm. The efficacy of T-SLNP was compared with commercial temoporfin formulation in terms of in vitro phototoxicity in 4T1 (murine mammary carcinoma) and MDA-MB-231(human br ...
DOI:
10.1016/j.jconrel.2016.09.009

29. A novel prototype of albumin nanoparticles fabricated by supramolecular cyclodextrin-adamantane association B Biointerfaces

Author:
Lee, Seunghyun; Lee, Changkyu; Kim, Bomi; Thao, Le Quang; Lee, Eun Seong; Kim, Jong Oh; Oh, Kyung Taek; Choi, Han-Gon; Youn, Yu Seok
Source:
Colloids and surfaces 2016 v.147 pp. 281-290
ISSN:
0927-7765
Subject:
biocompatibility,   etc   ; beta-cyclodextrin; chitosan; colloids; cytotoxicity; emulsifying; homogenization; human serum albumin; image analysis; inhibitory concentration 50; mice; mixing; nanoparticles; neoplasms; particle size; physiological transport; therapeutics;     Show all 17 Subjects
Abstract:
... Albumin has been viewed as one of the most attractive biomacromolecules for making nanoparticulate systems due to its biocompatibility and chemical functionality. Thus far, albumin nanoparticles (NPs) are prepared by several limited methods, such as, desolvation, emulsification or high-pressure homogenization. In this article, we introduce a new albumin NPs prototype fabricated via a ‘host’ (β-cyc ...
DOI:
10.1016/j.colsurfb.2016.08.009

30. An enzyme-mediated in situ hydrogel based on polyaspartamide derivatives for localized drug delivery and 3D scaffolds

Author:
Cheng, Xu; Liu, Jia; Wang, Lei; Wang, Ruoli; Liu, Zhilan; Zhuo, Renxi
Source:
RSC advances 2016 v.6 no.103 pp. 101334-101346
ISSN:
2046-2069
Subject:
biocompatibility,   etc   ; aminolysis; biocompatible materials; biodegradability; cell culture; crosslinking; drug carriers; gelation; hydrogels; hydrogen peroxide; hydrophilicity; inflammation; mice; peroxidase; polymers; rheology; subcutaneous injection; tyramine; viability;     Show all 19 Subjects
Abstract:
... An injectable and biodegradable enzymatically crosslinked hydrogel based on poly(α,β-aspartic acid) modified with tyramine (TA) and 3-amino-1-propanol (AP) (PASP-g-TA/AP) was prepared under physiological conditions in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H₂O₂). The polymer PASP-g-TA/AP was readily synthesized through aminolysis of polysuccinimide (PSI) with TA and su ...
DOI:
10.1039/c6ra18479k

31. Physicochemical and in vitro biocompatibility of films combining reconstituted bacterial cellulose with arabinogalactan and xyloglucan

Author:
Lucyszyn, Neoli; Ono, Lucy; Lubambo, Adriana Freire; Woehl, Marco A.; Sens, Camila V.; de Souza, Clayton F.; Sierakowski, Maria Rita
Source:
Carbohydrate polymers 2016 v.151 pp. 889-898
ISSN:
0144-8617
Subject:
biocompatibility,   etc   ; Guibourtia; Pereskia aculeata; X-ray diffraction; arabinogalactans; biocomposites; cellulose; contact angle; erythrocytes; fibroblasts; films (materials); hydrocolloids; hydrophilicity; leaves; mechanical properties; mice; scanning electron microscopy; seeds; xyloglucans;     Show all 19 Subjects
Abstract:
... Reconstituted cellulose films were generated using residual bacterial cellulose membranes mechanically defibrillated (RBC fibrils) recycled following wound dressing production via a dry-cast process. Arabinogalactan (AG) extracted from Pereskia aculeata leaves and/or a xyloglucan (GHXG) from Guibourtia hymenifolia seeds were incorporating into the RBC at various compositions, and new films were cr ...
DOI:
10.1016/j.carbpol.2016.06.027

32. Negatively charged gold nanoparticles as a dexamethasone carrier: stability in biological media and bioactivity assessment in vitro

Author:
Rossi, A.; Donati, S.; Fontana, L.; Porcaro, F.; Battocchio, C.; Proietti, E.; Venditti, I.; Bracci, L.; Fratoddi, I.
Source:
RSC advances 2016 v.6 no.101 pp. 99016-99022
ISSN:
2046-2069
Subject:
biocompatibility,   etc   ; T-lymphocytes; apoptosis; bioactive properties; cell cycle checkpoints; culture media; dexamethasone; drug carriers; human cell lines; mice; nanogold; neoplasm cells; sodium; sulfonates;     Show all 14 Subjects
Abstract:
... Gold nanoparticles (AuNPs) have been extensively used in biological applications because of their high biocompatibility, ease of characterization and the extensive knowledge of their surface chemistry. These features make AuNPs readily exploitable for drug delivery and novel diagnostic and therapeutic approaches. In a previous work, we showed that small size (5–10 nm) AuNPs functionalized by sodiu ...
DOI:
10.1039/c6ra19561j

33. Enhanced Therapeutic Efficacy of Doxorubicin for Breast Cancer Using Chitosan Oligosaccharide-Modified Halloysite Nanotubes

Author:
Yang, Jing; Wu, Yanping; Shen, Yan; Zhou, Changren; Li, Yi-Fang; He, Rong-Rong; Liu, Mingxian
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.40 pp. 26578-26590
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; antineoplastic activity; apoptosis; breast neoplasms; cardiomyocytes; chitosan; doxorubicin; drug therapy; flow cytometry; halloysite; inhibitory concentration 50; mice; mitochondria; nanocarriers; nanotubes; prices; toxicity;     Show all 17 Subjects
Abstract:
... Halloysite nanotubes (HNTs) are natural aluminosilicates with unique hollow lumen structure, also having high specific area, good biocompatibility, nontoxicity, and low price. Here, we designed a chitosan oligosaccharide-grafted HNTs (HNTs-g-COS) as a doxorubicin (DOX) carrier for treating breast cancer both in vitro and in vivo. The structure of HNTs-g-COS was first characterized by various metho ...
DOI:
10.1021/acsami.6b09074

34. Bacterial magnetic nanoparticles for photothermal therapy of cancer under the guidance of MRI

Author:
Chen, Chuanfang; Wang, Shunhao; Li, Linlin; Wang, Pingping; Chen, Changyou; Sun, Zhaoyu; Song, Tao
Source:
Biomaterials 2016 v.104 pp. 352-360
ISSN:
0142-9612
Subject:
biocompatibility,   etc   ; bacteria; energy; heat; irradiation; magnetic resonance imaging; membrane potential; mice; mitochondrial membrane; nanoparticles; neoplasm cells; neoplasms; reactive oxygen species; therapeutics; toxicity;     Show all 15 Subjects
Abstract:
... The bacterial magnetic nanoparticles (BMPs) are biomineralized by the magnetotactic bacteria and naturally covered with a layer of biomembrane. Herein, BMPs were isolated and firstly used for the photothermal therapy (PTT) of cancer under the guidance of magnetic resonance imaging (MRI) in vitro and in vivo. The results showed that BMPs could rapidly convert the energy of 808 nm near-infrared (NIR ...
DOI:
10.1016/j.biomaterials.2016.07.030

35. Castor oil‐based waterborne polyurethanes with tunable properties and excellent biocompatibility

Author:
Liu, Kai; Miao, Shida; Su, Zhiguo; Sun, Lijing; Ma, Guanghui; Zhang, Songping
Source:
European journal of lipid science and technology 2016 v.118 no.10 pp. 1512-1520
ISSN:
1438-7697
Subject:
biocompatibility,   etc   ; biodegradability; biopolymers; castor oil; dispersions; fibroblasts; glass transition temperature; hydrogen bonding; hydrophilicity; mice; petroleum; plastics; polystyrenes; polyurethanes; tensile strength; tissue culture;     Show all 16 Subjects
Abstract:
... Biopolymers materials with tunable properties are the spotlight in the polymer molecules design and synthesis. Here, we synthesize a series of castor oil based‐waterborne polyurethanes (CWPUs) with highly tunable properties by adjusting the content of 2,2‐dimethylolbutanoic acid (DMBA), a hydrophilic chain extender. The size of the polyurethane dispersions (PUDs) decreases from 120 nm to 20 nm, wh ...
DOI:
10.1002/ejlt.201500595

36. Improved Mechanical Properties and Sustained Release Behavior of Cationic Cellulose Nanocrystals Reinforeced Cationic Cellulose Injectable Hydrogels

Author:
You, Jun; Cao, Jinfeng; Zhao, Yanteng; Zhang, Lina; Zhou, Jinping; Chen, Yun
Source:
Biomacromolecules 2016 v.17 no.9 pp. 2839-2848
ISSN:
1526-4602
Subject:
biocompatibility,   etc   ; antineoplastic agents; cellulose; cross-linking reagents; cytotoxicity; gelation; hydrogels; liver neoplasms; mice; nanocomposites; nanocrystals; patient compliance; strength (mechanics); temperature; therapeutics;     Show all 15 Subjects
Abstract:
... Polysaccharide-based injectable hydrogels have several advantages in the context of biomedical use. However, the main obstruction associated with the utilization of these hydrogels in clinical application is their poor mechanical properties. Herein, we describe in situ gelling of nanocomposite hydrogels based on quaternized cellulose (QC) and rigid rod-like cationic cellulose nanocrystals (CCNCs), ...
DOI:
10.1021/acs.biomac.6b00646

37. Proteomic studies with a novel nano-magnetic chelating system to capture metalloproteins and its application in the preliminary study of monocyte and macrophage sub-secretome

Author:
Couto, Cláudia; Neves, Bruno; Ferreira, Rita; Daniel-da-Silva, Ana L.; Vitorino, Rui
Source:
Talanta 2016 v.158 pp. 110-117
ISSN:
0039-9140
Subject:
biocompatibility,   etc   ; albumins; cell culture; chromatography; culture media; fetal bovine serum; humans; macrophages; magnetism; metal ions; metalloproteins; mice; monitoring; monocytes; nanoparticles; protein secretion; proteomics; surface area;     Show all 18 Subjects
Abstract:
... A new chelating chromatography method was developed based in the use of magnetic iron oxide nanoparticles functionalized with EDTA-TMS ((N-(trimethoxysilylpropyl)ethylenediaminetriacetate trisodium salt). These particles combine a high surface area, biocompatibility and magnetic removal from solution, with the chelating affinity towards metal ions. The particles were used to selectively capture me ...
DOI:
10.1016/j.talanta.2016.05.051

38. In vivo efficacy, toxicity and biodistribution of ultra-long circulating desferrioxamine based polymeric iron chelator

Author:
Hamilton, Jasmine L.; Imran ul-haq, Muhammad; Abbina, Srinivas; Kalathottukaren, Manu Thomas; Lai, Benjamin F.L.; Hatef, Azadeh; Unniappan, Suraj; Kizhakkedathu, Jayachandran N.
Source:
Biomaterials 2016 v.102 pp. 58-71
ISSN:
0142-9612
Subject:
biocompatibility,   etc   ; Danio rerio; anemia; blood serum; body weight; chelating agents; deferoxamine; half life; iron; iron overload; lactate dehydrogenase; liver; mice; molecular weight; mortality; neurotoxicity; patients; polymers; urine;     Show all 19 Subjects
Abstract:
... Desferrioxamine (DFO) is currently in clinical use to remove iron from transfusion-dependent patients with β-thalassemia major, sickle-cell anemia and the myelodysplastic syndromes. However, its short half-life, burdensome, subcutaneous mode of administration and propensity to cause neurotoxicity at high doses greatly hinder its use. Thus, developing an optimized version of DFO with extended half- ...
DOI:
10.1016/j.biomaterials.2016.06.019

39. Melatonin in functionalized biomimetic constructs promotes rapid tissue regeneration in Wistar albino rats

Author:
Murali, Ragothaman; Thanikaivelan, Palanisamy; Cheirmadurai, Kalirajan
Source:
Journal of materials chemistry B 2016 v.4 no.35 pp. 5850-5862
ISSN:
2050-7518
Subject:
biocompatibility,   etc   ; albino; anti-inflammatory activity; biomimetics; cell lines; collagen; extracellular matrix; fibroblasts; gum arabic; melatonin; mice; oxidation; rats; tissue engineering; tissue repair;     Show all 15 Subjects
Abstract:
... The development of hybrid scaffolds mimicking the extracellular matrix with bioactive factors has great potential to regenerate tissues in tissue engineering and wound-healing applications. Herein, poly(dialdehyde) gum acacia was synthesized by the selective oxidation of gum acacia and was blended with collagen and melatonin to fabricate biomimetic hybrid scaffolds. The inclusion of poly(dialdehyd ...
DOI:
10.1039/c6tb01221c

40. Biomimetic Porous PLGA Scaffolds Incorporating Decellularized Extracellular Matrix for Kidney Tissue Regeneration

Author:
Lih, Eugene; Park, Ki Wan; Chun, So Young; Kim, Hyuncheol; Kwon, Tae Gyun; Joung, Yoon Ki; Han, Dong Keun
Source:
ACS applied materials 2016 v.8 no.33 pp. 21145-21154
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; biodegradability; biomimetics; blood vessels; dialysis; epithelial cells; extracellular matrix; ice; kidney diseases; kidneys; leaching; mechanical properties; mice; tissue engineering; tissue repair;     Show all 15 Subjects
Abstract:
... Chronic kidney disease is now recognized as a major health problem, but current therapies including dialysis and renal replacement have many limitations. Consequently, biodegradable scaffolds to help repairing injured tissue are emerging as a promising approach in the field of kidney tissue engineering. Poly(lactic-co-glycolic acid) (PLGA) is a useful biomedical material, but its insufficient bioc ...
DOI:
10.1021/acsami.6b03771

41. Lipid Cross-Linking of Nanolipoprotein Particles Substantially Enhances Serum Stability and Cellular Uptake

Author:
Gilmore, Sean F.; Blanchette, Craig D.; Scharadin, Tiffany M.; Hura, Greg L.; Rasley, Amy; Corzett, Michele; Pan, Chong-xian; Fischer, Nicholas O.; Henderson, Paul T.
Source:
ACS applied materials 2016 v.8 no.32 pp. 20549-20557
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; blood serum; crosslinking; drugs; exposure duration; gel chromatography; humans; intravenous injection; light scattering; lipid bilayers; mice; nanoparticles; phospholipids; urinary bladder neoplasms;     Show all 14 Subjects
Abstract:
... Nanolipoprotein particles (NLPs) consist of a discoidal phospholipid lipid bilayer confined by an apolipoprotein belt. NLPs are a promising platform for a variety of biomedical applications due to their biocompatibility, size, definable composition, and amphipathic characteristics. However, poor serum stability hampers the use of NLPs for in vivo applications such as drug formulation. In this stud ...
DOI:
10.1021/acsami.6b04609

42. Engineering phosphopeptide-decorated magnetic nanoparticles as efficient photothermal agents for solid tumor therapy

Author:
Wu, Man; Guo, Qiaoyan; Xu, Feng; Liu, Shujun; Lu, Xuehong; Wang, Jing; Gao, Hongwen; Luo, Ping
Source:
Journal of colloid and interface science 2016 v.476 pp. 158-166
ISSN:
0021-9797
Subject:
biocompatibility,   etc   ; animal experimentation; blood coagulation; breast neoplasms; coprecipitation; cytotoxicity; engineering; hemolysis; irradiation; ligands; magnetism; mice; nanoparticles; near infrared radiation; neoplasm cells; phototherapy;     Show all 16 Subjects
Abstract:
... Due to the high therapeutic efficiency and minimum damage towards normal tissues, phototherapy has drawn a great deal of attention in recent decades. Herein, we reported the synthesis of novel phosphopeptide-decorated magnetic nanoparticles (peptide-Fe3O4 nanoparticles), and their usages in photothermal therapy against solid tumor. By using a classical coprecipitation method and a facile ligand ex ...
DOI:
10.1016/j.jcis.2016.05.023

43. Indium-based and iodine-based labeling of HPMA copolymer–epirubicin conjugates: Impact of structure on the in vivo fate

Author:
Zhang, Libin; Zhang, Rui; Yang, Jiyuan; Wang, Jiawei; Kopeček, Jindřich
Source:
Journal of Controlled Release 2016 v.235 pp. 306-318
ISSN:
0168-3659
Subject:
biocompatibility,   etc   ; blood circulation; composite polymers; drugs; enzyme substrates; enzymes; females; humans; intravenous injection; iodine; kidneys; mice; molecular weight; ovarian neoplasms; pharmacokinetics; radiolabeling; radionuclides; remission;     Show all 18 Subjects
Abstract:
... Recently, we developed 2nd generation backbone degradable N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates which contain enzymatically cleavable sequences (GFLG) in both polymeric backbone and side-chains. This design allows using polymeric carriers with molecular weights above renal threshold without impairing their biocompatibility, thereby leading to significant improvement in ...
DOI:
10.1016/j.jconrel.2016.06.004
PubMed:
27266365
PubMed Central:
PMC5061135

44. Development of a reactive oxygen species (ROS)-responsive nanoplatform for targeted oral cancer therapy

Author:
LiBoth authors contributed equally to this work., Qing; Wen, Yong; You, Xinru; Zhang, Fenghe; Shah, Vishva; Chen, Xing; Tong, Dongdong; Wei, Xiujuan; Yin, Linlin; Wu, Jun; Xu, Xin
Source:
Journal of materials chemistry B 2016 v.4 no.27 pp. 4675-4682
ISSN:
2050-7518
Subject:
biocompatibility,   etc   ; antineoplastic activity; cell lines; drug delivery systems; drug therapy; drugs; mice; mouth neoplasms; nanoparticles; neoplasm cells; polymers; reactive oxygen species; tongue; toxicity;     Show all 14 Subjects
Abstract:
... In this study, for effective oral cancer therapy, a new targeted and ROS-triggered drug delivery nanoplatform was developed from the RGD–PEG–TK–PLGA polymer, in which the ROS-responsive TK containing linker was connected with PEG and PLGA. RGD in the drug delivery system (DDS) presented here was used to target cancer cells. This new nanoplatform shows high stability, good targeting ability, excell ...
DOI:
10.1039/c6tb01016d

45. Genipin-crosslinked gelatin microspheres as a strategy to prevent postsurgical peritoneal adhesions: In vitro and in vivo characterization

Author:
De Clercq, Kaat; Schelfhout, Charlotte; Bracke, Marc; De Wever, Olivier; Van Bockstal, Mieke; Ceelen, Wim; Remon, Jean Paul; Vervaet, Chris
Source:
Biomaterials 2016 v.96 pp. 33-46
ISSN:
0142-9612
Subject:
biocompatibility,   etc   ; abdominal cavity; cell viability; crosslinking; drug therapy; drugs; emulsifying; female fertility; gelatin; histopathology; in vivo studies; inflammation; mice; microparticles; models; pain; small intestine; solvents; stomach; surgery;     Show all 20 Subjects
Abstract:
... Peritoneal adhesions are a common complication after abdominal surgery. They cause small bowel obstruction, female infertility and chronic abdominal pain. Peritoneal adhesions also hamper uniform drug distribution in the peritoneal cavity, thereby reducing the efficacy of intraperitoneal chemotherapy after cytoreductive surgery.The goal of this study was to develop a formulation that prevents peri ...
DOI:
10.1016/j.biomaterials.2016.04.012

46. Cationic Polyphosphazene Vesicles for Cancer Immunotherapy by Efficient in Vivo Cytokine IL-12 Plasmid Delivery

Author:
Gao, Menghua; Zhu, Xiumei; Wu, Liping; Qiu, Liyan
Source:
Biomacromolecules 2016 v.17 no.6 pp. 2199-2209
ISSN:
1526-4602
Subject:
biocompatibility,   etc   ; blood proteins; colorectal neoplasms; deoxyribonucleases; dialysis; electrostatic interactions; encapsulation; genes; hydrophilicity; hydrophobicity; immune response; immunotherapy; interleukin-12; intravenous injection; lymphocytes; mice; plasmids; polyethylene glycol; toxicity; transfection;     Show all 20 Subjects
Abstract:
... To circumvent the severe toxicity of the systemic delivery of IL-12 protein and the limits of local administration of IL-12 gene, we constructed a polymersome system for systemic delivery of recombinant murine IL-12 plasmid (pmIL-12) based on amphiphilic polyphosphazenes containing weakly cationic N,N-diisopropylethylenediamine (DPA) as hydrophobic groups and monomethoxy poly(ethylene glycol) (mPE ...
DOI:
10.1021/acs.biomac.6b00433

47. Stimuli-Responsive Biodegradable Hyperbranched Polymer–Gadolinium Conjugates as Efficient and Biocompatible Nanoscale Magnetic Resonance Imaging Contrast Agents

Author:
Sun, Ling; Li, Xue; Wei, Xiaoli; Luo, Qiang; Guan, Pujun; Wu, Min; Zhu, Hongyan; Luo, Kui; Gong, Qiyong
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.16 pp. 10499-10512
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; biodegradability; cathepsin B; chemical structure; cytotoxicity; dendrites; ethylene glycol; gadolinium; magnetic resonance imaging; mice; molecular weight; neoplasms; polymerization; polymers; toxicity testing;     Show all 15 Subjects
Abstract:
... The efficacy and biocompatibility of nanoscale magnetic resonance imaging (MRI) contrast agents depend on optimal molecular structures and compositions. Gadolinium [Gd(III)] based dendritic macromolecules with well-defined and tunable nanoscale sizes are excellent candidates as multivalent MRI contrast agents. Here, we propose a novel alternate preparation of biodegradable hyperbranched polymer–ga ...
DOI:
10.1021/acsami.6b00980

48. Graphene oxide based coatings on nitinol for biomedical implant applications: effectively promote mammalian cell growth but kill bacteria

Author:
Zhao, Changhong; Pandit, Santosh; Fu, Yifeng; Mijakovic, Ivan; Jesorka, Aldo; Liu, Johan
Source:
RSC advances 2016 v.6 no.44 pp. 38124-38134
ISSN:
2046-2069
Subject:
biocompatibility,   etc   ; Escherichia coli; antimicrobial properties; bacteria; bacterial colonization; cell adhesion; cell growth; cell membranes; coatings; fluorescence; graphene; graphene oxide; mice; osteoblasts; scanning electron microscopes; scanning electron microscopy; tissues;     Show all 17 Subjects
Abstract:
... An important clinical challenge is the development of implant surfaces which have good integration with the surrounding tissues and simultaneously inhibit bacterial colonization thus preventing infection. Recently, graphene oxide (GO) a derivative of graphene, has gained considerable attention in the biomedical field owing to its biocompatibility, surface functionalizability and promising antimicr ...
DOI:
10.1039/c6ra06026a

49. Evaluation of biodegradable polymer conduits – poly(l-lactic acid) – for guiding sciatic nerve regeneration in mice

Author:
Goulart, Camila Oliveira; Pereira Lopes, Fátima Rosalina; Monte, Zulmira Oliveira; Dantas, Severino Valentim; Souto, Allana; Oliveira, Júlia Teixeira; Almeida, Fernanda Martins; Tonda-Turo, Chiara; Pereira, Cristina Cardoso; Borges, Cristiano Piacsek; Martinez, Ana Maria Blanco
Source:
Methods 2016 v.99 pp. 28-36
ISSN:
1046-2023
Subject:
biocompatibility,   etc   ; allergenicity; autografting; biocompatible materials; biodegradability; blood vessels; cell viability; electron microscopy; extrusion; mice; models; morphometry; nerve fibers; nerve tissue; polyesters; polylactic acid; porous media; quantitative analysis;     Show all 18 Subjects
Abstract:
... Polymeric biomaterials are often used for stimulating nerve regeneration. Among different conduits, poly(lactide acid) – PLA polymer is considered to be a good substrate due to its biocompatibility and resorbable characteristics. This polymer is an aliphatic polyester which has been mostly used in biomedical application. It is an organic compound with low allergenic potential, low toxicity, high b ...
DOI:
10.1016/j.ymeth.2015.09.008

50. A “submunition” dual-drug system based on smart hollow NaYF₄/apoferritin nanocage for upconversion imaging

Author:
Zhou, Jie; Chen, Shanshan; Sun, Chong; Du, Qiuzheng; Luo, Pei; Du, Bin; Yao, Hanchun
Source:
RSC advances 2016 v.6 no.40 pp. 33443-33454
ISSN:
2046-2069
Subject:
biocompatibility,   etc   ; doxorubicin; P-glycoproteins; image analysis; intravenous injection; ferritin; nanomaterials; nanocomposites; signal transduction; verapamil; mice; folic acid; toxicity; drug delivery systems; apoptosis; breast neoplasms; drug resistance;     Show all 17 Subjects
Abstract:
... Synergetic therapy has exhibited important potential for the treatment of cancers, especially for drug-resistant cancers. In this report, bifunctional nanomaterials based on doxorubicin (DOX)-loaded NaYF₄ and verapamil (Vp)-loaded apoferritin nanocage dual-drug system (DOX/NaYF₄-Vp/AFn-FA) were synthesized for in vivo upconversion imaging and enhanced chemotherapy in breast cancers. Moreover, foli ...
DOI:
10.1039/c5ra24285a