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1. Dietary potato peel extract reduces the toxicity of cholesterol oxidation products in rats

Author:
Hsieh, You-Liang; Yeh, Yen-Hung; Lee, Ya-Ting; Huang, Chih-Yang
Source:
Journal of functional foods 2016 v.27 pp. 461-471
ISSN:
1756-4646
Subject:
rats,   etc   ; alanine transaminase; alkaline phosphatase; antioxidant activity; aspartate transaminase; blood; catalase; cholesterol; creatinine; diet; gene expression; glutathione; glutathione peroxidase; high performance liquid chromatography; liver; messenger RNA; oxidation; potatoes; superoxide dismutase; toxicity; urea nitrogen;     Show all 21 Subjects
Abstract:
... We determined the polyphenolic profiles of the potato peel by HPLC. To elucidate the effect of potato peel extract (PPE) on the toxicity of cholesterol oxidation products (COPs) in rats, a synthetic polyphenolic mixture was prepared, mimicking the composition of PPE. Six groups were treated with a control diet, an oxidized cholesterol diet, a PPE diet, an oxidized cholesterol plus PPE diet, and va ...
DOI:
10.1016/j.jff.2016.09.019

2. Histopathological and biochemical investigations of protective role of honey in rats with experimental aflatoxicosis

Author:
Yaman, Turan; Yener, Zabit; Celik, Ismail
Source:
BMC complementary and alternative medicine 2016 v.16 no.1 pp. 232
ISSN:
1472-6882
Subject:
rats,   etc   ; aflatoxicosis; aflatoxins; alanine transaminase; alternative medicine; antioxidant activity; antioxidants; aspartate transaminase; blood serum; brain; carcinogens; catalase; diet; erythrocytes; glutathione; glutathione transferase; glutathione-disulfide reductase; heart; histology; histopathology; honey; kidneys; lipid peroxidation; liver; lungs; nephroprotective effect; stomach ulcers; superoxide dismutase; tissues; traditional medicine;     Show all 30 Subjects
Abstract:
... BACKGROUND: Natural honey (honey) is considered as a part of traditional medicine all over the world. It has both antimicrobial and antioxidant properties, useful in stimulation of wounds and burns healing and gastric ulcers treatment. The aim of this study, for the first time, was to investigate the antioxidant properties and protective role of honey against carcinogen chemical aflatoxin (AF) exp ...
DOI:
10.1186/s12906-016-1217-7
PubMed:
27440086
PubMed Central:
PMC4955256

3. Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats

Author:
Zhang, Haiyan; Shen, Wen-Jun; Li, Yihang; Bittner, Alex; Bittner, Stefanie; Tabassum, Juveria; Cortez, Yuan F.; Kraemer, Fredric B.; Azhar, Salman
Source:
Nutrition & metabolism 2016 v.13 no.1 pp. 63
ISSN:
1743-7075
Subject:
rats,   etc   ; fatty acids; nordihydroguaiaretic acid; free fatty acids; acetyl coenzyme A; Larrea tridentata; genes; lipogenesis; blood pressure; beta oxidation; stearoyl-CoA desaturase; glucose; males; skeletal muscle; insulin resistance; hypertriglyceridemia; gene expression regulation; fatty liver; transcription factors; metabolic syndrome; body weight; transporters; adipose tissue; blood glucose; triacylglycerols; DNA microarrays; transcription (genetics); ligases; insulin; diabetes; diet; liver; hypertension; animal models;     Show all 34 Subjects
Abstract:
... Nordihydroguaiaretic acid (NDGA), the main metabolite of Creosote Bush, has been shown to have profound effects on the core components of metabolic syndrome, including lowering of blood glucose, free fatty acids and triglyceride levels, attenuating elevated blood pressure in several rodent models of dyslipidemia, and improving body weight, insulin resistance, diabetes and hypertension. In the pres ...
DOI:
10.1186/s12986-016-0121-y

4. Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro

Author:
Khuntamoon, Tanyalak; Thepouyporn, Apanchanid; Kaewprasert, Sarunya; Prangthip, Pattaneeya; Pooudoung, Somchai; Chaisri, Urai; Maneesai, Phudit; Kwanbunjan, Karunee
Source:
BMC veterinary research 2016 v.12 no.1 pp. 17
ISSN:
1746-6148
Subject:
rats,   etc   ; Ames test; Salmonella Typhimurium; adverse effects; animal models; blood chemistry; blood serum; body weight; chronic diseases; diet; dogs; ethanol; foods; hematologic tests; histopathology; industry; kidneys; liver; long term effects; market value; mutagenicity; pet foods; pets; weight gain;     Show all 24 Subjects
Abstract:
... BACKGROUND: The commercial pet-food industry and the market value of the pet industry have increased. Most owners are concerned about their pets’ health, and prefer commercial pet foods as their regular diet. This study thus aimed to determine whether a selection of local generic-brand dry canine foods had any potential to promote chronic disease. METHODS: Five local, generic-brand, dry canine foo ...
DOI:
10.1186/s12917-016-0640-9
PubMed:
26785914
PubMed Central:
PMC4719534

5. Vitamin A deficiency modulates iron metabolism independent of hemojuvelin (Hfe2) and bone morphogenetic protein 6 (Bmp6) transcript levels

Author:
Mendes, Juliana Frossard Ribeiro; Siqueira, Egle Machado de Almeida; de Brito e Silva, João Gabriel Marques; Arruda, Sandra Fernandes
Source:
Genes & nutrition 2016 v.11 no.1 pp. 1
ISSN:
1555-8932
Subject:
rats,   etc   ; bone morphogenetic proteins; diet; gene expression; gene expression regulation; hepcidin; iron; iron absorption; liver; males; messenger RNA; mothers; retinoic acid; signal transduction; spleen; vitamin A; vitamin A deficiency;     Show all 17 Subjects
Abstract:
... BACKGROUND: Considering that vitamin A deficiency modulates hepcidin expression and consequently affects iron metabolism, we evaluated the effect of vitamin A deficiency in the expression of genes involved in the hemojuvelin (HJV)-bone morphogenetic protein 6 (BMP6)-small mothers against decapentaplegic protein (SMAD) signaling pathway. METHODS: Male Wistar rats were treated: control AIN-93G diet ...
DOI:
10.1186/s12263-016-0519-4
PubMed:
27551308
PubMed Central:
PMC4968453

6. Weight restoration on a high carbohydrate refeeding diet promotes rapid weight regain and hepatic lipid accumulation in female anorexic rats

Author:
Giles, Erin D.; Hagman, Jennifer; Pan, Zhaoxing; MacLean, Paul S.; Higgins, Janine A.
Source:
Nutrition & metabolism 2016 v.13 no.1 pp. 18
ISSN:
1743-7075
Subject:
rats,   etc   ; adipose tissue; adolescents; anorexia nervosa; body composition; body weight; calorimetry; carbohydrates; corticosterone; diet; energy intake; females; lipids; liver; metabolites; models; overfeeding; palatability; patients; refeeding; resting energy expenditure; weight gain;     Show all 22 Subjects
Abstract:
... BACKGROUND: There is currently no standard clinical refeeding diet for the treatment of anorexia nervosa (AN). To provide the most efficacious AN clinical care, it is necessary to define the metabolic effects of current refeeding diets. METHODS: An activity-based model of anorexia nervosa (AN) was used in female rats. AN was induced over 7d by timed access to low fat (LF) diet with free access to ...
DOI:
10.1186/s12986-016-0077-y

7. Fluctuations in metabolite content in the liver of magnesium-deficient rats

Author:
Shigematsu, Mei; Nakagawa, Ryosuke; Tomonaga, Shozo; Funaba, Masayuki; Matsui, Tohru
Source:
The British journal of nutrition 2016 v.116 no.10 pp. 1694-1699
ISSN:
1475-2662
Subject:
rats,   etc   ; Internet; citric acid; cystathionine; diet; enzymes; fumaric acid; gluconeogenesis; glucose; glucose 6-phosphate; glycolysis; laboratory animals; liver; males; malic acid; messenger RNA; metabolites; metabolome; metabolomics; methionine; nutrient deficiencies; pentose phosphate cycle; serine; spermidine; taurine; threonine; tricarboxylic acid cycle;     Show all 27 Subjects
Abstract:
... Mg deficiency induces various metabolic disturbances including glucose metabolism in the liver. However, no comprehensive information is currently available on the metabolic pathways affected by Mg deficiency. The present study examined metabolite content in the liver of Mg-deficient rats using a metabolomic analysis. In this study, 4-week-old, male Sprague–Dawley rats were fed a control diet or a ...
DOI:
10.1017/S0007114516003676
PubMed:
27825399

8. Modulatory role of Co-enzyme Q10 on methionine and choline deficient diet-induced non-alcoholic steatohepatitis (NASH) in albino rats

Author:
Saleh, Dalia O.; Ahmed, Rania F.; Amin, Mohamed M.
Source:
Applied Physiology, Nutrition, and Metabolism 2016 v.42 no.3 pp. 243-249
ISSN:
1715-5320
Subject:
rats,   etc   ; B-lymphocytes; alanine transaminase; albino; albumins; alkaline phosphatase; ammonia; aspartate transaminase; bilirubin; biomarkers; blood serum; brain; brain damage; cages; choline; coenzyme Q10; diet; drugs; fatty liver; gamma-glutamyltransferase; histopathology; immunohistochemistry; interleukin-6; liver; liver function; metabolism; methionine; nitric oxide; oral administration; proliferating cell nuclear antigen; tissues;     Show all 31 Subjects
Abstract:
... The present study aimed to evaluate the hepato-protective and neuro-protective activity of Co-enzyme Q10 (CoQ10) on non-alcoholic steatohepatitis (NASH) in albino rats induced by methionine and choline-deficient (MCD) diet. Rats were fed an MCD diet for 8 weeks to induce non-alcoholic steatohepatitis. CoQ10 (10 mg/(kg·day)⁻¹) was orally administered for 2 consecutive weeks. Twenty-four hours after ...
DOI:
10.1139/apnm-2016-0320

9. Actinidia arguta supplementation protects aorta and liver in rats with induced hypercholesterolemia

Author:
Leontowicz, Maria; Leontowicz, Hanna; Jesion, Iwona; Bielecki, Wojciech; Najman, Katarzyna; Latocha, Piotr; Park, Yong-Seo; Gorinstein, Shela
Source:
Nutrition research 2016 v.36 no.11 pp. 1231-1242
ISSN:
0271-5317
Subject:
rats,   etc   ; 2,2-diphenyl-1-picrylhydrazyl; Actinidia arguta; antioxidant activity; aorta; blood serum; cholesterol; diet; fatty liver; fibrinogen; hypercholesterolemia; kiwifruit; laboratory animals; lipid composition; liver; males; prothrombin; villi; Poland;     Show all 19 Subjects
Abstract:
... There are no published results focusing on the study of hardy kiwifruit as a supplementation to the atherogenic diet. We hypothesized that hardy kiwifruit (Actinidia arguta (A. arguta)) from Poland possess better pro-healthy action than two Asian varieties (Hayward and Bidan). We tested this hypothesis by measuring the metabolic reactions of rats loaded with 1% cholesterol and supplemented with 5% ...
DOI:
10.1016/j.nutres.2016.09.010

10. Autofluorescence discrimination of metabolic fingerprint in nutritional and genetic fatty liver models

Author:
Croce, Anna C.; Ferrigno, Andrea; Di Pasqua, Laura G.; Berardo, Clarissa; Piccolini, Valeria Maria; Bertone, Vittorio; Bottiroli, Giovanni; Vairetti, Mariapia
Source:
Journal of photochemistry and photobiology 2016 v.164 pp. 13-20
ISSN:
1011-1344
Subject:
rats,   etc   ; NADP (coenzyme); biomarkers; choline; diet; disease course; energy metabolism; fatty acids; fatty liver; flavins; fluorescent dyes; homozygosity; leptin receptors; liver; methionine; models; mutation; prediction; risk;     Show all 19 Subjects
Abstract:
... Liver tissue autofluorescence (AF) has been characterized in two models with a different potential to undergo disease progression to steatohepatitis: Wistar rats, administered with a methionine, choline deficient diet (MCD), and Zucker (fa/fa) rats, homozygous for a spontaneous mutation of leptin receptor. AF spectra were recorded from liver tissue cryostatic sections by microspectrofluorometry, u ...
DOI:
10.1016/j.jphotobiol.2016.09.015

11. Hyperglycemia, oxidative stress, liver damage and dysfunction in alloxan-induced diabetic rat are prevented by Spirulina supplementation

Author:
Gargouri, Manel; Magné, Christian; El Feki, Abdelfattah
Source:
Nutrition research 2016 v.36 no.11 pp. 1255-1268
ISSN:
0271-5317
Subject:
rats,   etc   ; Spirulina; algae; alloxan; animal disease models; antioxidant activity; antioxidants; bilirubin; blood glucose; blood serum; body weight changes; catalase; diabetic complications; diet; enzyme activity; glutathione peroxidase; glycogen; histology; hyperglycemia; insulin; laboratory animals; lipid peroxidation; liver; low density lipoprotein cholesterol; males; medicinal plants; oxidative stress; superoxide dismutase; toxicity; transaminases; triacylglycerols;     Show all 31 Subjects
Abstract:
... Medicinal plants have long been used against life-threatening diseases including diabetes, with more or less success. Some of these plants have been shown to possess antioxidant activities, which could help improving diabetes inconveniences. In that context, we investigated the effects of spirulina supplementation on alloxan-induced diabetic rats, hypothesizing that co-administration of spirulina ...
DOI:
10.1016/j.nutres.2016.09.011

12. The effects of alpha-cypermethrin exposure on biochemical and redox parameters in pregnant rats and their newborns

Author:
Hocine, Leila; Merzouk, Hafida; Merzouk, Sid Ahmed; Ghorzi, Hafeda; Youbi, Meriem; Narce, Michel
Source:
Pesticide biochemistry and physiology 2016 v.134 pp. 49-54
ISSN:
0048-3575
Subject:
rats,   etc   ; alanine transaminase; alkaline phosphatase; aspartate transaminase; blood glucose; body weight; cypermethrin; diet; fetal development; lipids; liver; neonates; oxidative stress; pregnancy; progeny;     Show all 15 Subjects
Abstract:
... Pyrethroid insecticides are extensively used in agriculture and in household activities. During pregnancy, they might affect maternal metabolic status and there after fetal development. In this work, we studied metabolic and redox effects of low dose alpha-cypermethrin exposure in pregnant rats and their offspring. The diet containing alpha cypermethrin at 0.02mg/kg/day was consumed during the ent ...
DOI:
10.1016/j.pestbp.2016.04.007

13. Estimation of ellagic acid and/or repaglinide effects on insulin signaling, oxidative stress, and inflammatory mediators of liver, pancreas, adipose tissue, and brain in insulin resistant/type 2 diabetic rats

Author:
Amin, Mohamed M.; Arbid, Mahmoud S.
Source:
Applied Physiology, Nutrition, and Metabolism 2016 v.42 no.2 pp. 181-192
ISSN:
1715-5320
Subject:
rats,   etc   ; adipokines; adiponectin receptors; adipose tissue; albino; ammonia; animal disease models; apoptosis; blood serum; body weight; brain; cytokines; diabetic complications; diet; ellagic acid; enzymes; fructose; glucose; glucose transporters; insulin; insulin resistance; lipid composition; liver; manganese; metabolism; neoplasms; noninsulin-dependent diabetes mellitus; oxidative stress; pancreas; protein phosphorylation;     Show all 30 Subjects
Abstract:
... Even though ellagic acid has previously been valued in many models of cancer, so far its full mechanistic effect as a natural antiapoptotic agent in the prevention of type 2 diabetes complications has not been completely elucidated, which was the goal of this study. We fed albino rats a high-fat fructose diet (HFFD) for 2 months to induce insulin resistance/type 2 diabetes and then treated the rat ...
DOI:
10.1139/apnm-2016-0429

14. Antioxidant and hepatoprotective properties of dried fig against oxidative stress and hepatotoxicity in rats

Author:
Turan, Abdullah; Celik, Ismail
Source:
International journal of biological macromolecules 2016 v.91 pp. 554-559
ISSN:
0141-8130
Subject:
rats,   etc   ; Ficus carica; antioxidant activity; antioxidants; blood serum; diet; enzymes; ethanol; figs; free radicals; hepatoprotective effect; hepatotoxicity; histopathology; liver; malondialdehyde; oxidative stress; tissues;     Show all 17 Subjects
Abstract:
... The aim of this study was to investigate the hepatoprotective effect and antioxidant role of dried fig (DF) (Ficus carica L.) against ethanol-induced oxidative stress. Experiment was designed as normal Control, 20% ethanol, 10% DF and 10% DF+20% ethanol groups. The hepatoprotective and antioxidant role of the dried DF supplementation feed against ethanol induced oxidatif stress were evaluated by l ...
DOI:
10.1016/j.ijbiomac.2016.06.009

15. Green tea extract activates AMPK and ameliorates white adipose tissue metabolic dysfunction induced by obesity

Author:
Rocha, Andréa; Bolin, Anaysa Paola; Cardoso, Claudia Andrea Lima; Otton, Rosemari
Source:
European journal of nutrition 2016 v.55 no.7 pp. 2231-2244
ISSN:
1436-6207
Subject:
rats,   etc   ; AMP-activated protein kinase; beta oxidation; cafeteria foods; diet; droplets; gene expression; glucose transporters; green tea; hyperlipidemia; insulin resistance; lipid content; lipids; lipogenesis; lipolysis; liver; males; messenger RNA; obesity; polyphenols; weight gain; white adipose tissue;     Show all 22 Subjects
Abstract:
... PURPOSE: Beneficial effects of green tea (GT) polyphenols against obesity have been reported. However, until this moment the molecular mechanisms of how green tea can modulate obesity and regulates fat metabolism, particularly in adipose tissue, remain poorly understood. The aim of this study was to evaluate the role of GT extract in the adipose tissue of obese animals and its effect on weight gai ...
DOI:
10.1007/s00394-015-1033-8

16. Hepato- and gastro- protective activity of purified oat 1–3, 1–4-β-d-glucans of different molecular weight

Author:
Suchecka, Dominika; Harasym, Joanna; Wilczak, Jacek; Gromadzka-Ostrowska, Joanna
Source:
International journal of biological macromolecules 2016 v.91 pp. 1177-1185
ISSN:
0141-8130
Subject:
rats,   etc   ; antioxidant activity; antioxidants; beta-glucans; diet; enteritis; inflammation; lipid peroxidation; liver; molecular weight; nutritional intervention; oats; oxidative stress; stomach; viscoelasticity;     Show all 15 Subjects
Abstract:
... Protective and antioxidant properties of highly purified oat β-glucans of high and low molecular weight in liver and stomach were evaluated. The novelty in approach was to determine whether dietary β-glucans affect the parameters of oxidative stress directly in the stomach and indirectly in the liver, especially in inflammation states. Physicochemical properties e.g. viscoelastic was found as stri ...
DOI:
10.1016/j.ijbiomac.2016.06.062

17. Soy isoflavones reduce acetaminophen-induced liver injury by inhibiting cytochrome P-450-mediated bioactivation and glutathione depletion and increasing urinary drug excretion in rats

Author:
Liu, Yun-Ta; Chen, Yu-Hua; Uramaru, Naoto; Lin, Ai-Hsuan; Yang, Hui-Ting; Lii, Chong-Kuei; Yao, Hsien-Tsung
Source:
Journal of functional foods 2016 v.26 pp. 135-143
ISSN:
1756-4646
Subject:
rats,   etc   ; acetaminophen; alanine transaminase; cytochrome P-450; diet; drug excretion; functional foods; glutathione; hepatotoxicity; isoflavones; liver; liver diseases; phytopharmaceuticals; protein synthesis; transporters;     Show all 15 Subjects
Abstract:
... Soy isoflavones (SI) are phytochemicals with various biological activities. Acetaminophen can cause acute liver injury when overdosed. In this study, to investigate the effects of SI on the metabolism and toxicity of acetaminophen in liver, rats were fed a controlled diet with or without 120 mg/kg SI-rich product for 2 weeks and were then intraperitoneally injected with acetaminophen. Cytochrome P ...
DOI:
10.1016/j.jff.2016.07.011

18. A combined supplementation of vitamin B₁₂ and omega-3 fatty acids across two generations improves cardiometabolic variables in rats

Author:
Khaire, Amrita; Rathod, Richa; Randhir, Karuna; Kale, Anvita; Joshi, Sadhana
Source:
Food & function 2016 v.7 no.9 pp. 3910-3919
ISSN:
2042-650X
Subject:
rats,   etc   ; adults; adverse effects; blood lipids; blood pressure; carbon cycle; cholesterol; diet; docosahexaenoic acid; fatty acid composition; folic acid; laboratory animals; lipid metabolism; liver; males; omega-3 fatty acids; pregnancy outcome; progeny; triacylglycerols; vitamin B12; weight gain;     Show all 21 Subjects
Abstract:
... Our earlier studies indicate that micronutrients (vitamin B₁₂, folic acid) and omega-3 fatty acids especially docosahexaenoic acid (DHA) are interlinked in one carbon cycle. The present study examines the effects of a sustained vitamin B₁₂ deficiency/supplementation in the presence of omega-3 fatty acids across two generations on the pregnancy outcome and cardiometabolic profile [blood pressure, p ...
DOI:
10.1039/c6fo00148c

19. Protective effects of fish oil on pre-diabetes: a lipidomic analysis of liver ceramides in rats

Author:
TaltavullCurrent address: Department of Basic Medical Science, Universitat Rovira i Virgili, 43202, Reus, Spain., Núria; Ras, Rosa; Mariné, Sílvia; Romeu, Marta; Giralt, Montserrat; Méndez, Lucía; Medina, Isabel; Ramos-Romero, Sara; Torres, Josep L.; Nogués, M. Rosa
Source:
Food & function 2016 v.7 no.9 pp. 3981-3988
ISSN:
2042-650X
Subject:
rats,   etc   ; animal models; biomarkers; ceramides; diet; fish oils; glucose; insulin; insulin resistance; liver; omega-3 fatty acids; polyunsaturated fatty acids; protective effect; signal transduction; sucrose; tissues;     Show all 16 Subjects
Abstract:
... A high intake of fat and sucrose can dramatically increase bioactive lipids such as ceramides in tissues. Ceramides regulate several steps in the insulin signal pathway. The effects of n-3 PUFA on insulin resistance are inconsistent, especially in liver. We investigated the effect of n-3 PUFA (EPA/DHA 1 : 1) from fish oil on hepatic ceramides in a pre-diabetic animal model. Three groups of rats we ...
DOI:
10.1039/c6fo00589f

20. Vascular- and hepato-protective effects of passion fruit seed extract containing piceatannol in chronic high-fat diet-fed rats

Author:
IshihataThese authors contributed equally., Akira; Maruki-Uchida, Hiroko; Gotoh, Nozomi; Kanno, Sumika; Aso, Yoshitaka; Togashi, Satoshi; Sai, Masahiko; Ito, Tatsuhiko; Katano, Yumi
Source:
Food & function 2016 v.7 no.9 pp. 4075-4081
ISSN:
2042-650X
Subject:
rats,   etc   ; blood lipids; blood serum; cardiac output; cardiovascular diseases; cholesterol; diet; hepatoprotective effect; histology; hypertrophy; lipid composition; liver; liver cirrhosis; models; passion fruits; platelet aggregation; seed extracts; tissue weight; triacylglycerols;     Show all 19 Subjects
Abstract:
... The effects of chronic administration of piceatannol-enriched (9.5% w/w) passion fruit seed extract (PFSE) on the cardiovascular damage induced in a high-fat (HF) diet-fed model of Fischer 344 rats were evaluated. Rats were fed the control, HF, or HF diets containing PFSE (0.5% w/w) for 16 weeks, and the effects of the various diets on the tissue weight, serum lipid profile, hepatic fibrosis, hepa ...
DOI:
10.1039/c6fo01067a