Publication year rev: 7984-2016 / Text availability: Full Text

1. (+) RNA virus replication compartments: a safe home for (most) viral replication

Author:: Ana Shulla; Glenn Randall
Source:: Current opinion in microbiology 2016 v.32 pp. 82-88
ISSN:: 1369-5274
Subject:: biological properties and phenomena; ssRNA viruses; virus replication
Abstract:: ... This review describes recent advances in our understanding of the mechanisms by which (+) RNA viruses establish their replication niche. ...
DOI:: 10.1016/j.mib.2016.05.003
PubMed:: 27253151
PubMed Central:: PMC4983521
: https://doi.org/10.1016/j.mib.2016.05.003

2. (-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice

Author:: Eleonora Cremonini; Ahmed Bettaieb; Fawaz G. Haj; Cesar G. Fraga; Patricia I. Oteiza
Source:: Archives of biochemistry and biophysics 2016 v.599 pp. 13-21
ISSN:: 0003-9861
Subject:: blood glucose; foods; high fat diet; humans; insulin; insulin receptors; insulin resistance; laboratory animals; liver; mice; mitogen-activated protein kinase; noninsulin-dependent diabetes mellitus; obesity; protein kinase C; protein-tyrosine-phosphatase; public health; tissues
Abstract:: ... Obesity constitutes a major public health concern, being frequently associated with type 2 diabetes (T2D). Evidence from studies in humans and experimental animals suggest that consumption of the flavan-3-ol (-)-epicatechin (EC) and of EC-rich foods may improve insulin sensitivity. To further understand the potential benefits of dietary EC consumption on insulin resistance, this study investigated ...
DOI:: 10.1016/j.abb.2016.03.006
PubMed:: 26968772
PubMed Central:: PMC5523407
: https://doi.org/10.1016/j.abb.2016.03.006

3. (BB)-Carboryne Complex of Ruthenium: Synthesis by Double B–H Activation at a Single Metal Center

Author:: Eleazer Bennett J.; Smith Mark D.; Popov Alexey A.; Peryshkov Dmitry V.
Source:: Journal of the American Chemical Society 2016 v.138 no.33 pp. 10531-10538
ISSN:: 1520-5126
Subject:: boron; ligands; ruthenium
Abstract:: ... The first example of a transition metal (BB)-carboryne complex containing two boron atoms of the icosahedral cage connected to a single exohedral metal center (POBBOP)Ru(CO)₂ (POBBOP = 1,7-OP(i-Pr)₂-2,6-dehydro-m-carborane) was synthesized by double B–H activation within the strained m-carboranyl pincer framework. Theoretical calculations revealed that the unique three-membered (BB)>Ru metalacycle ...
DOI:: 10.1021/jacs.6b05172
PubMed:: 27526855
PubMed Central:: PMC4999960
: https://doi.org/10.1021/jacs.6b05172

4. (Bio)transformation of 2,4-dinitroanisole (DNAN) in soils

Author:: Christopher I. Olivares; Leif Abrell; Raju Khatiwada; Jon Chorover; Reyes Sierra-Alvarez; Jim A. Field
Source:: Journal of hazardous materials 2016 v.304 pp. 214-221
ISSN:: 0304-3894
Subject:: adsorption; aerobic conditions; anaerobic conditions; aromatic amines; biotransformation; chemical reactions; environmental fate; hydrogen; mass spectrometry; soil; soil organic carbon; toxicity
Abstract:: ... Recent studies have begun to assess the environmental fate and toxicity of 2,4-dinitroanisole (DNAN), an insensitive munition compound of interest to defense agencies. Aerobic and anaerobic DNAN biotransformation in soils was evaluated in this study. Under aerobic conditions, there was little evidence of transformation; most observed removal was attributed to adsorption and subsequent slow chemica ...
DOI:: 10.1016/j.jhazmat.2015.10.059
PubMed:: 26551225
PubMed Central:: PMC4695256
: https://doi.org/10.1016/j.jhazmat.2015.10.059

5. (Z)-9-Tricosene based Musca domestica lure study on a garbage dump yard using plywood sticky trap baited with fish meal

Author:: S. T. Bino Sundar; Bhaskaran Ravi Latha; R. Vijayashanthi; Serma Saravana Pandian
Source:: Journal of parasitic diseases 2016 v.40 no.1 pp. 32-35
ISSN:: 0971-7196
Subject:: Musca domestica; Sarcophaga; acetone; bait traps; fish meal; hexane; municipal solid waste; parasitoses; plywood; solvents; sticky traps
Abstract:: ... A study was undertaken to find out the efficacy of (Z)-9-Tricosene in attracting flies in a garbage dump yard using a plywood sticky glue trap with fish meal as a food bait. (Z)-9-Tricosene was dissolved in acetone or hexane before application on a filter paper strip fixed at the centre of the trap. The traps were left in areas of the garbage dump yard of high fly activity for 6 h and then the tra ...
DOI:: 10.1007/s12639-013-0400-8
PubMed:: 27065593
PubMed Central:: PMC4815855
: https://doi.org/10.1007/s12639-013-0400-8

6. (±)-Evodiakine, A Pair of Rearranged Rutaecarpine-Type Alkaloids From Evodia rutaecarpa

Author:: Yan-Hong Li; Yu Zhang; Li-Yan Peng; Xiao-Nian Li; Qin-Shi Zhao; Rong-Tao Li; Xing-De Wu
Source:: Nat. Prod. Bioprospect. 2016 v.6 no.6 pp. 291-296
ISSN:: 2192-2195
Subject:: Euodia; X-ray diffraction; alkaloids; anti-inflammatory activity; circular dichroism spectroscopy; cytotoxicity; enantiomers; fruits; high performance liquid chromatography; mass spectrometry; nuclear magnetic resonance spectroscopy
Abstract:: ... (±)-Evodiakine (1a and 1b), a pair of rearranged rutaecarpine-type alkaloids with an unprecedented 6/5/5/7/6 ring system, were isolated from the nearly ripe fruits of Evodia rutaecarpa. Separation of the enantiomers have been achieved by chiral HPLC column. The structures of (±)-evodiakine were unambiguously elucidated by 1D and 2D NMR spectra, mass spectrometry, and single-crystal X-ray diffracti ...
DOI:: 10.1007/s13659-016-0113-7
PubMed:: 27873184
PubMed Central:: PMC5136374
: https://doi.org/10.1007/s13659-016-0113-7

7. (−)-Rhazinilam and the diphenylpyridazinone NSC 613241: Two compounds inducing the formation of morphologically similar tubulin spirals but binding apparently to two distinct sites on tubulin

Author:: Ruoli Bai; Ernest Hamel
Source:: Archives of biochemistry and biophysics 2016 v.604 pp. 63-73
ISSN:: 0003-9861
Subject:: binding sites; guanosine triphosphate; microtubules; paclitaxel; polymers; tubulin
Abstract:: ... The most potent microtubule assembly inhibitor of newer diphenylpyridazinone derivatives examined was NSC 613241. Because NSC 613241 and (−)-rhazinilam also induce the formation of similar 2-filament spirals, these aberrant reactions were compared. Spiral formation with both compounds was enhanced by GTP and inhibited by GDP and by 15 other inhibitors of microtubule assembly. Similarly, microtubul ...
DOI:: 10.1016/j.abb.2016.06.008
PubMed:: 27311615
PubMed Central:: PMC4955782
: https://doi.org/10.1016/j.abb.2016.06.008

8. 0.9% saline is neither normal nor physiological

Author:: Heng Li; Shi-ren Sun; John Q. Yap; Jiang-hua Chen; Qi Qian
Source:: Journal of Zhejiang University 2016 v.17 no.3 pp. 181-187
ISSN:: 1673-1581
Subject:: acid-base balance; acidosis; adults; adverse effects; alkalosis; bicarbonates; blood flow; blood serum; edema; education; electrolytes; gastrointestinal system; hospitals; hyperkalemia; image analysis; kidneys; morbidity; mortality; myosin light chains; oxygen; parenchyma (animal tissue); patients; phosphorylation; physicians; rodents; surgery; vomiting; China
Abstract:: ... The purpose of this review is to objectively evaluate the biochemical and pathophysiological properties of 0.9% saline (henceforth: saline) and to discuss the impact of saline infusion, specifically on systemic acid-base balance and renal hemodynamics. Studies have shown that electrolyte balance, including effects of saline infusion on serum electrolytes, is often poorly understood among practicin ...
DOI:: 10.1631/jzus.B1500201
PubMed:: 26984838
PubMed Central:: PMC4794509
: https://doi.org/10.1631/jzus.B1500201

9. 1,25-Dihydroxy vitamin D3 stimulates system A amino acid transport in primary human trophoblast cells

Author:: Yi-Yung Chen; Theresa L. Powell; Thomas Jansson
Source:: Molecular and Cellular Endocrinology 2016 pp. -
ISSN:: 0303-7207
Subject:: amino acid transporters; amino acids; cholecalciferol; fetal development; gene expression; humans; infants; messenger RNA; physiological transport; pregnancy; small for gestational age; small interfering RNA; trophoblast; vitamin D deficiency; vitamin status
Abstract:: ... Vitamin D deficiency during pregnancy is linked to adverse perinatal outcomes such as small for gestational age infants. Recent evidence suggests that changes in placental amino acid transport contribute to altered fetal growth. We tested the hypothesis that 1,25-dihydroxy vitamin D3 increases the gene expression of System A and L amino acid transporter isoforms and stimulates placental amino acid ...
DOI:: 10.1016/j.mce.2016.12.009
PubMed:: 27956114
PubMed Central:: PMC5673492
: https://doi.org/10.1016/j.mce.2016.12.009

10. 1,25-Dihydroxyvitamin D induces the glutamate transporter SLC1A1 and alters glutamate handling in non-transformed mammary cells

Author:: Sarah Beaudin; JoEllen Welsh
Source:: Molecular and Cellular Endocrinology 2016 v.424 pp. 34-41
ISSN:: 0303-7207
Subject:: glutathione; NADP-glucose-6-phosphate dehydrogenase; humans; energy metabolism; transporters; NADP (coenzyme); calcitriol; genes; mammary glands; epithelium; glutamic acid
Abstract:: ... Genomic profiling of immortalized human mammary epithelial (hTERT-HME1) cells identified several metabolic genes, including the membrane glutamate transporter, SLC1A1, as 1,25-dihydroxyvitamin D3 (1,25D) regulated. In these studies we have surveyed the effects of 1,25D on known glutamate transporters and evaluated its impact on cellular glutamate handling. We confirm that expression of SLC1A1 and ...
DOI:: 10.1016/j.mce.2016.01.011
PubMed:: 26774511
PubMed Central:: PMC4779372
: https://doi.org/10.1016/j.mce.2016.01.011

11. 1,25-Dihydroxyvitamin D3 modulates calcium transport in goat mammary epithelial cells in a dose- and energy-dependent manner

Author:: Feifei Sun; Yangchun Cao; Chao Yu; Xiaoshi Wei; Junhu Yao
Source:: Journal of animal science and biotechnology 2016 v.7 no.1 pp. 41
ISSN:: 2049-1891
Subject:: Ca2-transporting ATPase; Western blotting; calcitriol; calcium; calcium-binding proteins; cell proliferation; dairy goats; dose response; energy; enzyme activity; epithelial cells; gene expression; genes; glucose; hexokinase; humans; in vitro culture; mammary glands; messenger RNA; metabolism; milk; milk composition; plasma membrane; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; rodents; secretion
Abstract:: ... BACKGROUND: Calcium is a vital mineral and an indispensable component of milk for ruminants. The regulation of transcellular calcium transport by 1,25-dihydroxyvitamin D₃ (1,25-(OH)₂D₃, the active form of vitamin D) has been confirmed in humans and rodents, and regulators, including vitamin D receptor (VDR), calcium binding protein D₉ₖ (calbindin-D₉ₖ), plasma membrane Ca²⁺-ATPase 1b (PMCA1b), PMAC ...
DOI:: 10.1186/s40104-016-0101-0
PubMed:: 27471592
PubMed Central:: PMC4964070
: https://doi.org/10.1186/s40104-016-0101-0

12. 1,3,5-Benzenetribenzoic Acid on Cu(111) and Graphene/Cu(111): A Comparative STM Study

Author:: Li Jun; Gottardi Stefano; Solianyk Leonid; Moreno-López Juan Carlos; Stöhr Meike
Source:: The Journal of Physical Chemistry C 2016 v.120 no.32 pp. 18093-18098
ISSN:: 1932-7455
Subject:: annealing; carboxylic acids; copper; graphene; hydrogen bonding; scanning tunneling microscopy
Abstract:: ... The self-assembly of 1,3,5-benzenetribenzoic acid (BTB) molecules on both Cu(111) and epitaxial graphene grown on Cu(111) were studied by scanning tunneling microscopy (STM) and low-energy electron diffraction (LEED) under ultrahigh vacuum conditions. On Cu(111), the BTB molecules were found to mainly arrange in close-packed structures through H-bonding between the (partially) deprotonated carboxy ...
DOI:: 10.1021/acs.jpcc.6b05541
PubMed:: 27588158
PubMed Central:: PMC5002934
: https://doi.org/10.1021/acs.jpcc.6b05541

13. 1,3-Dipolar Cycloaddition with Diazo Groups: Noncovalent Interactions Overwhelm Strain

Author:: Gold Brian; Aronoff Matthew R.; Raines Ronald T.
Source:: Organic letters 2016 v.18 no.18 pp. 4466-4469
ISSN:: 1523-7052
Subject:: azides; chemical structure; cycloaddition reactions; diazo compounds; methanol
Abstract:: ... Like azides, diazoacetamides undergo 1,3-dipolar cycloadditions with oxanorbornadienes (OND) in a reaction that is accelerated by the relief of strain in the transition state. The cycloaddition of a diazoacetamide with unstrained ethyl 4,4,4-trifluoro-2-butynoate is, however, 35-fold faster than with the analogous OND because of favorable interactions with the fluoro groups. Its rate constant (k = ...
DOI:: 10.1021/acs.orglett.6b01938
PubMed:: 27599159
PubMed Central:: PMC5148626
: https://doi.org/10.1021/acs.orglett.6b01938

14. 1,3-Dipolar Cycloadditions of Diazo Compounds in the Presence of Azides

Author:: Aronoff Matthew R.; Gold Brian; Raines Ronald T.
Source:: Organic letters 2016 v.18 no.7 pp. 1538-1541
ISSN:: 1523-7052
Subject:: alkynes; azides; chemical structure; chemoselectivity; cycloaddition reactions; diazo compounds; electronics; metabolism; nisin
Abstract:: ... The diazo group has untapped utility in chemical biology. The tolerance of stabilized diazo groups to cellular metabolism is comparable to that of azido groups. However, chemoselectivity has been elusive, as both groups undergo 1,3-dipolar cycloadditions with strained alkynes. Removing strain and tuning dipolarophile electronics yields diazo group selective 1,3-dipolar cycloadditions that can be p ...
DOI:: 10.1021/acs.orglett.6b00278
PubMed:: 26981746
PubMed Central:: PMC5141246
: https://doi.org/10.1021/acs.orglett.6b00278

15. 1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus

Author:: Fu Peng; La Scott; MacMillan John B.
Source:: Journal of natural products 2016 v.79 no.3 pp. 455-462
ISSN:: 1520-6025
Subject:: Streptomyces; pyrrolizidine alkaloids; spectral analysis
Abstract:: ... Two new 1,3-oxazin-6-one derivatives (1 and 2) and six new bohemamine-type pyrrolizidine alkaloids (3–8) were isolated from the marine-derived Streptomyces spinoverrucosus strain SNB-048. Their structures including the absolute configurations were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Compounds 1 and 2 possess a γ ...
DOI:: 10.1021/acs.jnatprod.5b00604
PubMed:: 26489038
PubMed Central:: PMC5435457
: https://doi.org/10.1021/acs.jnatprod.5b00604

16. 1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure

Author:: Nadine M. Shaban; Ke Shi; Ming Li; Hideki Aihara; Reuben S. Harris
Source:: Journal of Molecular Biology 2016 v.428 pp. 2307-2316
ISSN:: 0022-2836
Subject:: DNA; Human immunodeficiency virus 1; active sites; catalytic activity; cobalt; crystal structure; crystallization; cytosine; disulfide bonds; divalent metals; pH; pathogens; phylogeny; zinc
Abstract:: ... The APOBEC3 family of DNA cytosine deaminases is capable of restricting the replication of HIV-1 and other pathogens. Here, we report a 1.92 Å resolution crystal structure of the Vif-binding and catalytic domain of APOBEC3F (A3F). This structure is distinct from the previously published APOBEC and phylogenetically related deaminase structures, as it is the first without zinc in the active site. We ...
DOI:: 10.1016/j.jmb.2016.04.026
PubMed:: 27139641
PubMed Central:: PMC5142242
: https://doi.org/10.1016/j.jmb.2016.04.026

17. 100Hz neutron radiography at the BOA beamline using a parabolic focussing guide

Author:: Pavel Trtik; Manuel Morgano; Roman Bentz; Eberhard Lehmann
Source:: MethodsX 2016 v.3 pp. 535-541
ISSN:: 2215-0161
Subject:: deuterium oxide; droplets; image analysis; liquids; mixing; neutrons; radiography; semiconductors; titration
Abstract:: ... The recent developments in scientific complementary metal oxide semiconductor (sCMOS) detector technology allow for imaging of relevant processes with very high temporal resolution with practically negligible readout time. However, it is neutron intensity that limits the high temporal resolution neutron imaging. In order to partially overcome the neutron intensity problem for the high temporal res ...
DOI:: 10.1016/j.mex.2016.10.001
PubMed:: 27774412
PubMed Central:: PMC5067979
: https://doi.org/10.1016/j.mex.2016.10.001

18. 11-Step Total Synthesis of (−)-Maoecrystal V

Author:: Cernijenko Artiom; Risgaard Rune; Baran Phil S.
Source:: Journal of the American Chemical Society 2016 v.138 no.30 pp. 9425-9428
ISSN:: 1520-5126
Subject:: bioactive properties; biosynthesis; diterpenoids; enantiomers
Abstract:: ... An expedient, practical, and enantioselective route to the highly congested ent-kaurane diterpene maoecrystal V is presented. This route, which has been several years in the making, is loosely modeled after a key pinacol shift in the proposed biosynthesis. Only 11 steps, many of which are strategic in that they build key skeletal bonds and incorporate critical functionalities, are required to acce ...
DOI:: 10.1021/jacs.6b06623
PubMed:: 27457680
PubMed Central:: PMC4974602
: https://doi.org/10.1021/jacs.6b06623

19. 11-Step Total Synthesis of Araiosamines

Author:: Tian Maoqun; Yan Ming; Baran Phil S.
Source:: Journal of the American Chemical Society 2016 v.138 no.43 pp. 14234-14237
ISSN:: 1520-5126
Subject:: alkaloids; bacteria; guanidines; stereochemistry; synthesis
Abstract:: ... A concise route to a small family of exotic marine alkaloids known as the araiosamines has been developed, and their absolute configuration has been assigned. The dense array of functionality, high polarity, and rich stereochemistry coupled with equilibrating topologies present an unusual challenge for chemical synthesis and an opportunity for innovation. Key steps involve the use of a new reagent ...
DOI:: 10.1021/jacs.6b09701
PubMed:: 27748593
PubMed Central:: PMC5095662
: https://doi.org/10.1021/jacs.6b09701

20. 11-Step Total Synthesis of Pallambins C and D

Author:: Martinez Luisruben P.; Umemiya Shigenobu; Wengryniuk Sarah E.; Baran Phil S.
Source:: Journal of the American Chemical Society 2016 v.138 no.24 pp. 7536-7539
ISSN:: 1520-5126
Subject:: ethers; furfuryl alcohol; terpenoids
Abstract:: ... The structurally intriguing terpenes pallambins C and D have been assembled in only 11 steps from a cheap commodity chemical: furfuryl alcohol. This synthesis, which features a redox-economic approach free of protecting-group manipulations, assembles all four-ring systems via a sequential cyclization strategy. Of these four-ring constructing operations, two are classical (Robinson annulation and M ...
DOI:: 10.1021/jacs.6b04816
PubMed:: 27284962
PubMed Central:: PMC4919752
: https://doi.org/10.1021/jacs.6b04816

21. 13C kinetic isotope effects on the reaction of a flavin amine oxidase determined from whole molecule isotope effects

Author:: José R. Tormos; Marina B. Suarez; Paul F. Fitzpatrick
Source:: Archives of biochemistry and biophysics 2016 v.612 pp. 115-119
ISSN:: 0003-9861
Subject:: carbon; cleavage (chemistry); deuterium; enzymes; flavoproteins; isotopes; metabolism; nitrogen; oxidation; solvents
Abstract:: ... A large number of flavoproteins catalyze the oxidation of amines. Because of the importance of these enzymes in metabolism, their mechanisms have previously been studied using deuterium, nitrogen, and solvent isotope effects. While these results have been valuable for computational studies to distinguish among proposed mechanisms, a measure of the change at the reacting carbon has been lacking. We ...
DOI:: 10.1016/j.abb.2016.10.018
PubMed:: 27815088
PubMed Central:: PMC5257176
: https://doi.org/10.1016/j.abb.2016.10.018

22. 13C metabolic flux analysis of microbial and mammalian systems is enhanced with GC-MS measurements of glycogen and RNA labeling

Author:: Christopher P. Long; Jennifer Au; Jacqueline E. Gonzalez; Maciek R. Antoniewicz
Source:: Metabolic engineering 2016 v.38 pp. 65-72
ISSN:: 1096-7176
Subject:: Escherichia coli; RNA; amino acids; biological models; biomass; biomedical research; gas chromatography-mass spectrometry; glucose; glycogen; hydrolysis; isotope labeling; mammals; metabolic engineering; metabolic flux analysis; metabolism; metabolites; mutants; pentose phosphate cycle; proteins; quantitative analysis; ribose; xylose
Abstract:: ... ¹³C metabolic flux analysis (¹³C-MFA) is a widely used tool for quantitative analysis of microbial and mammalian metabolism. Until now, ¹³C-MFA was based mainly on measurements of isotopic labeling of amino acids derived from hydrolyzed biomass proteins and isotopic labeling of extracted intracellular metabolites. Here, we demonstrate that isotopic labeling of glycogen and RNA, measured with gas c ...
DOI:: 10.1016/j.ymben.2016.06.007
PubMed:: 27343680
PubMed Central:: PMC5845444
: https://doi.org/10.1016/j.ymben.2016.06.007

23. 14-day toxicity studies of tetravalent and pentavalent vanadium compounds in Harlan Sprague Dawley rats and B6C3F1/N mice via drinking water exposure

Author:: Georgia K. Roberts; Matthew D. Stout; Brian Sayers; Dawn M. Fallacara; Milton R. Hejtmancik; Suramya Waidyanatha; Michelle J. Hooth
Source:: Toxicology reports 2016 v.3 pp. 531-538
ISSN:: 2214-7500
Subject:: chronic toxicity; females; gait; human health; humans; males; oral exposure; sodium; sulfates; vanadium; vanadyl ions
Abstract:: ... The National Toxicology Program (NTP) performed short-term toxicity studies of tetra- and pentavalent vanadium compounds, vanadyl sulfate and sodium metavanadate, respectively. Due to widespread human exposure and a lack of chronic toxicity data, there is concern for human health following oral exposure to soluble vanadium compounds.To compare the potency and toxicological profile of vanadyl sulfa ...
DOI:: 10.1016/j.toxrep.2016.05.001
PubMed:: 28042531
PubMed Central:: PMC5193388
: https://doi.org/10.1016/j.toxrep.2016.05.001

24. 15‐F2t‐Isoprostane Concentrations and Oxidant Status in Lactating Dairy Cattle with Acute Coliform Mastitis

Author:: V. Mavangira; M.J. Mangual; J.C. Gandy; L.M. Sordillo
Source:: Journal of veterinary internal medicine 2016 v.30 no.1 pp. 339-347
ISSN:: 0891-6640
Subject:: Holstein; animal tissues; biomarkers; case-control studies; coliform bacteria; correlation; dairy cows; enzyme-linked immunosorbent assay; humans; inflammation; lactation; liquid chromatography; mammary glands; mastitis; milk; oxidants; oxidative stress; tandem mass spectrometry; urine
Abstract:: ... BACKGROUND: Severe mammary tissue damage during acute coliform mastitis in cattle is partially caused by oxidative stress. Although considered a gold standard biomarker in some human conditions, the utility of 15‐F₂ₜ‐Isoprostanes (15‐F₂ₜ‐Isop) in detecting oxidative stress in dairy cattle has not been validated. HYPOTHESIS: Concentrations of 15‐F₂ₜ‐Isop in plasma, urine, and milk correlate with ch ...
DOI:: 10.1111/jvim.13793
PubMed:: 26566597
PubMed Central:: PMC4913657
CHORUS:: 10.1111/jvim.13793
Chorus Open Access:: 10.1111/jvim.13793
: https://doi.org/10.1111/jvim.13793

25. 16S rRNA amplicon sequencing dataset for conventionalized and conventionally raised zebrafish larvae

Author:: Daniel J. Davis; Elizabeth C. Bryda; Catherine H. Gillespie; Aaron C. Ericsson
Source:: Data in Brief 2016 v.8 pp. 938-943
ISSN:: 2352-3409
Subject:: Danio rerio; data collection; metagenomics; microorganisms
Abstract:: ... Data presented here contains metagenomic analysis regarding the sequential conventionalization of germ-free zebrafish embryos. Zebrafish embryos that underwent a germ-free sterilization process immediately after fertilization were promptly exposed to and raised to larval stage in conventional fish water. At 6 days postfertilization (dpf), these “conventionalized” larvae were compared to zebrafish ...
DOI:: 10.1016/j.dib.2016.06.057
PubMed:: 27508247
PubMed Central:: PMC4961299
: https://doi.org/10.1016/j.dib.2016.06.057

26. 17O NMR Investigation of Water Structure and Dynamics

Author:: Keeler Eric G.; Michaelis Vladimir K.; Griffin Robert G.
Source:: Journal of physical chemistry 2016 v.120 no.32 pp. 7851-7858
ISSN:: 1520-5207
Subject:: barium; bound water; magnetic fields; nuclear magnetic resonance spectroscopy; physical chemistry; prediction; spinning; temperature
Abstract:: ... The structure and dynamics of the bound water in barium chlorate monohydrate were studied with ¹⁷O nuclear magnetic resonance (NMR) spectroscopy in samples that are stationary and spinning at the magic-angle in magnetic fields ranging from 14.1 to 21.1 T. ¹⁷O NMR parameters of the water were determined, and the effects of torsional oscillations of the water molecule on the ¹⁷O quadrupolar coupling ...
DOI:: 10.1021/acs.jpcb.6b05755
PubMed:: 27454747
PubMed Central:: PMC5418864
: https://doi.org/10.1021/acs.jpcb.6b05755

27. 17β-Estradiol alters oxidative damage and oxidative stress response protein expression in the mouse mammary gland

Author:: Lisi Yuan; Alicia K. Dietrich; Yvonne S. Ziegler; Ann M. Nardulli
Source:: Molecular and Cellular Endocrinology 2016 v.426 pp. 11-21
ISSN:: 0303-7207
Subject:: DNA; DNA repair; carcinogenesis; estradiol; lipid peroxidation; lipids; mammary glands; mice; ovariectomy; oxidative stress; protein synthesis; proteins; stress response; superoxide dismutase
Abstract:: ... Although substantial evidence has demonstrated that parity and 17β-estradiol (E2) reduce mammary carcinogenesis, it is not clear how this protection is conferred. Thus, we examined the effects of parity and E2 treatment in the mammary glands of ovariectomized 15 week-old virgin mice, 15 week-old primiparous mice, and 9 month-old retired breeders. E2 treatment significantly increased lipid peroxida ...
DOI:: 10.1016/j.mce.2016.02.007
PubMed:: 26872614
PubMed Central:: PMC4818174
: https://doi.org/10.1016/j.mce.2016.02.007

28. 18S rDNA dataset profiling microeukaryotic populations within Chicago area nearshore waters

Author:: Daniel Searle; Emily Sible; Alexandria Cooper; Catherine Putonti
Source:: Data in Brief 2016 v.6 pp. 526-529
ISSN:: 2352-3409
Subject:: aquatic food webs; data collection; databases; freshwater; genes; surface water; surveys; Illinois; Lake Michigan
Abstract:: ... Despite their critical role in the aquatic food web and nutrient cycling, microeukaryotes within freshwater environments are under-studied. Herein we present the first high-throughput molecular survey of microeukaryotes within Lake Michigan. Every two weeks from May 13 to August 5, 2014, we collected surface water samples from the nearshore waters of four Chicago area beaches: Gillson Park, Montro ...
DOI:: 10.1016/j.dib.2015.12.042
PubMed:: 26904716
PubMed Central:: PMC4724708
: https://doi.org/10.1016/j.dib.2015.12.042

29. 193 nm Ultraviolet Photodissociation Mass Spectrometry for Phosphopeptide Characterization in the Positive and Negative Ion Modes

Author:: Robinson Michelle R.; Taliaferro Juliana M.; Dalby Kevin N.; Brodbelt Jennifer S.
Source:: Journal of Proteome Research 2016 v.15 no.8 pp. 2739-2748
ISSN:: 1535-3907
Subject:: casein; data collection; dissociation; energy; ionization; ions; liquid chromatography; phosphates; phosphopeptides; photolysis; proteome; proteomics; tandem mass spectrometry
Abstract:: ... Advances in liquid chromatography tandem mass spectrometry (LC–MS/MS) have permitted phosphoproteomic analysis on a grand scale, but ongoing challenges specifically associated with confident phosphate localization continue to motivate the development of new fragmentation techniques. In the present study, ultraviolet photodissociation (UVPD) at 193 nm is evaluated for the characterization of phosph ...
DOI:: 10.1021/acs.jproteome.6b00289
PubMed:: 27425180
PubMed Central:: PMC5481846
: https://doi.org/10.1021/acs.jproteome.6b00289

30. 193 nm Ultraviolet Photodissociation Mass Spectrometry of Tetrameric Protein Complexes Provides Insight into Quaternary and Secondary Protein Topology

Author:: Morrison Lindsay J.; Brodbelt Jennifer S.
Source:: Journal of the American Chemical Society 2016 v.138 no.34 pp. 10849-10859
ISSN:: 1520-5126
Subject:: dissociation; energy; gases; hemoglobin; mass spectrometry; multiprotein complexes; photolysis; prealbumin; protein-protein interactions; streptavidin; topology
Abstract:: ... Protein–protein interfaces and architecture are critical to the function of multiprotein complexes. Mass spectrometry-based techniques have emerged as powerful strategies for characterization of protein complexes, particularly for heterogeneous mixtures of structures. In the present study, activation and dissociation of three tetrameric protein complexes (streptavidin, transthyretin, and hemoglobi ...
DOI:: 10.1021/jacs.6b03905
PubMed:: 27480400
PubMed Central:: PMC5479422
: https://doi.org/10.1021/jacs.6b03905

31. 1H NMR and FT-IR dataset based structural investigation of poly(amic acid)s and polyimides from 4,4′-diaminostilbene

Author:: Amit Kumar; Seiji Tateyama; Katsuaki Yasaki; Mohammad Asif Ali; Naoki Takaya; Rajeev Singh; Tatsuo Kaneko
Source:: Data in Brief 2016 v.7 pp. 123-128
ISSN:: 2352-3409
Subject:: data collection; diamines; polymers; solvents
Abstract:: ... Structural investigation of polymers by various available analytical methods is important in order to correlate the structure with polymer properties for which understanding of polymer structure is very important factor. The data presented here in this article shows the ¹H NMR spectra used for the characterization of prepared poly(amic acid)s (PAAs). It is often difficult to assigns the peak in NM ...
DOI:: 10.1016/j.dib.2016.02.006
PubMed:: 26933669
PubMed Central:: PMC4764896
: https://doi.org/10.1016/j.dib.2016.02.006

32. 1H-NMR dataset for hydroxycoumarins –Aesculetin, 4-Methylumbelliferone, and umbelliferone

Author:: Rui Galhano dos Santos; João Carlos Moura Bordado; Maria Margarida Mateus
Source:: Data in Brief 2016 v.8 pp. 308-311
ISSN:: 2352-3409
Subject:: data collection; nuclear magnetic resonance spectroscopy; umbelliferones
Abstract:: ... Herein, the integrated raw data regarding the ¹H-NMR, experiments of Aesculetin, 4-Methylumbelliferone, and umbelliferone, in Acetone-d⁶ at 25°C, are presented for further analysis and comparison purposes, for whom may be interested. ...
DOI:: 10.1016/j.dib.2016.05.048
PubMed:: 27331107
PubMed Central:: PMC4909709
: https://doi.org/10.1016/j.dib.2016.05.048

33. 1H‐NMR screening for the high‐throughput determination of genotype and environmental effects on the content of asparagine in wheat grain

Author:: Delia I. Corol; Catherine Ravel; Marianna Rakszegi; Gilles Charmet; Zoltan Bedo; Michael H. Beale; Peter R. Shewry; Jane L. Ward
Source:: Plant biotechnology journal 2016 v.14 no.1 pp. 128-139
ISSN:: 1467-7644
Subject:: acrylamides; asparagine; breeding; cooking; crops; cultivars; food industry; genotype; genotyping; growers; neurotoxicity; screening; wheat; wheat flour
Abstract:: ... Free asparagine in cereals is known to be the precursor of acrylamide, a neurotoxic and carcinogenic product formed during cooking processes. Thus, the development of crops with lower asparagine is of considerable interest to growers and the food industry. In this study, we describe the development and application of a rapid ¹H‐NMR‐based analysis of cereal flour, that is, suitable for quantifying ...
DOI:: 10.1111/pbi.12364
PubMed:: 25816894
PubMed Central:: PMC4949679
: https://doi.org/10.1111/pbi.12364

34. 1α,25-Dihydroxyvitamin D Inhibits the Metastatic Capability of MCF10CA1a and MDA-MB-231 Cells in an In Vitro Model of Breast to Bone Metastasis

Author:: Tomasz Wilmanski; Alle Barnard; Mukti R. Parikh; Julia Kirshner; Kimberly Buhman; John Burgess; Dorothy Teegarden
Source:: Nutrition and cancer 2016 v.68 no.7 pp. 1202-1209
ISSN:: 1532-7914
Subject:: basement membrane; breast neoplasms; cadherins; gene expression; genes; metabolites; metastasis; models; neoplasm cells; patients; vitamin D
Abstract:: ... Breast cancer metastasis to the bone continues to be a major health problem, with approximately 80% of advanced breast cancer patients expected to develop bone metastasis. Although the problem of bone metastasis persists, current treatment options for metastatic cancer patients are limited. In this study, we investigated the preventive role of the active vitamin D metabolite, 1α,25-dihydroxyvitami ...
DOI:: 10.1080/01635581.2016.1213868
PubMed:: 27552186
PubMed Central:: PMC5047026
: https://doi.org/10.1080/01635581.2016.1213868

35. 2-Aryl-5-carboxytetrazole as a New Photoaffinity Label for Drug Target Identification

Author:: Herner András; Marjanovic Jasmina; Lewandowski Tracey M.; Marin Violeta; Patterson Melanie; Miesbauer Laura; Ready Damien; Williams Jon; Vasudevan Anil; Lin Qing
Source:: Journal of the American Chemical Society 2016 v.138 no.44 pp. 14609-14615
ISSN:: 1520-5126
Subject:: benzophenones; drugs; photoaffinity labeling; ligands; active sites; mass spectrometry; case studies; binding capacity
Abstract:: ... Photoaffinity labels are powerful tools for dissecting ligand–protein interactions, and they have a broad utility in medicinal chemistry and drug discovery. Traditional photoaffinity labels work through nonspecific C–H/X–H bond insertion reactions with the protein of interest by the highly reactive photogenerated intermediate. Herein, we report a new photoaffinity label, 2-aryl-5-carboxytetrazole ...
DOI:: 10.1021/jacs.6b06645
PubMed:: 27740749
PubMed Central:: PMC5115731
: https://doi.org/10.1021/jacs.6b06645

36. 2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists

Author:: Vergelli Claudia; Schepetkin Igor A.; Ciciani Giovanna; Cilibrizzi Agostino; Crocetti Letizia; Giovannoni Maria Paola; Guerrini Gabriella; Iacovone Antonella; Kirpotina Liliya N.; Khlebnikov Andrei I.; Ye Richard D.; Quinn Mark T.
Source:: Bioorganic & Medicinal Chemistry pp. -
ISSN:: 0968-0896
Subject:: chemistry; median effective concentration; peptides; therapeutics
Abstract:: ... N-Formyl peptide receptors (FPRs: FPR1, FPR2, and FPR3) are G protein-coupled receptors that play key roles in modulating immune cells. FPRs represent potentially important therapeutic targets for the development of drugs that could enhance endogenous anti-inflammation systems associated with various pathologies, thereby reducing the progression of inflammatory conditions. Previously, we identifie ...
Handle:: 10113/7310938
DOI:: 10.1016/j.bmc.2016.04.019
CHORUS:: 10.1016/j.bmc.2016.04.019
: https://doi.org/10.1016/j.bmc.2016.04.019

37. 2-Cys peroxiredoxin is required in successful blood-feeding, reproduction, and antioxidant response in the hard tick Haemaphysalis longicornis

Author:: Kodai Kusakisako; Remil Linggatong Galay; Rika Umemiya-Shirafuji; Emmanuel Pacia Hernandez; Hiroki Maeda; Melbourne Rio Talactac; Naotoshi Tsuji; Masami Mochizuki; Kozo Fujisaki; Tetsuya Tanaka
Source:: Parasites & vectors 2016 v.9 no.1 pp. 457
ISSN:: 1756-3305
Subject:: RNA interference; Haemaphysalis longicornis; ticks; Western blotting; egg weight; genes; blood; oxidative stress; hydrogen peroxide; iron; midgut; gene expression; hatching; oxygen; tissues; messenger RNA; peroxiredoxin; body weight; tick control; larvae; quantitative polymerase chain reaction; proteins; protein synthesis; vertebrates
Abstract:: ... BACKGROUND: Ticks are obligate hematophagous arthropods that feed on vertebrate blood that contains iron. Ticks also concentrate host blood with iron; this concentration of the blood leads to high levels of iron in ticks. The host-derived iron reacts with oxygen in the tick body and this may generate high levels of reactive oxygen species, including hydrogen peroxide (H₂O₂). High levels of H₂O₂ ca ...
DOI:: 10.1186/s13071-016-1748-2
PubMed:: 27542835
PubMed Central:: PMC4992251
: https://doi.org/10.1186/s13071-016-1748-2

38. 2-D DIGE proteomic profiles of three strains of Fusarium graminearum grown in agmatine or glutamic acid medium

Author:: Tommaso Serchi; Matias Pasquali; Céline C. Leclercq; Sébastien Planchon; Lucien Hoffmann; Jenny Renaut
Source:: Data in Brief 2016 v.6 pp. 985-988
ISSN:: 2352-3409
Subject:: Fusarium graminearum; agmatine; data collection; glutamic acid; proteomics
Abstract:: ... 2D DIGE proteomics data obtained from three strains belonging to Fusarium graminearum s.s. species growing in a glutamic acid or agmatine containing medium are provided.A total of 381 protein species have been identified which do differ for abundance among the two treatments and among the strains (ANOVA<0.05 and abundance ratio>±1.3).Data on the diversity of protein species profiles between the tw ...
DOI:: 10.1016/j.dib.2016.01.043
PubMed:: 26981549
PubMed Central:: PMC4778272
: https://doi.org/10.1016/j.dib.2016.01.043

39. 2-amino-1-methyl-6-phenylimidazo(4,5-b) pyridine (PhIP) induces gene expression changes in JAK/STAT and MAPK pathways related to inflammation, diabetes and cancer

Author:: Lora J. Rogers; Alexei G. Basnakian; Mohammed S. Orloff; Baitang Ning; Aiwei Yao-Borengasser; Vinay Raj; Susan Kadlubar
Source:: Nutrition & metabolism 2016 v.13 no.1 pp. 54
ISSN:: 1743-7075
Subject:: adipocytes; adipose tissue; binding proteins; carbon; carcinogens; chronic diseases; cytotoxicity; diabetes; gene expression; genes; human cell lines; humans; inflammation; insulin; leptin; meat; mitogen-activated protein kinase; neoplasms; obesity; prostaglandin synthase; pyridines; radionuclides; reverse transcriptase polymerase chain reaction; risk; temperature; transcription factors
Abstract:: ... BACKGROUND: 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a heterocyclic aromatic amine (HCA) formed in meat that is cooked at high temperatures and then ingested, can potentially be retained in human adipose tissues. METHODS: To determine if PhIP is bioactive in the adipocyte, we exposed a human adipocyte cell line,HepG2 and Caco-2 cells to low dose PhIP. Uptake and retention of PhIP wa ...
DOI:: 10.1186/s12986-016-0111-0
PubMed:: 27547236
PubMed Central:: PMC4992261
: https://doi.org/10.1186/s12986-016-0111-0

40. 2-cyclohexylamino-5,8-dimethoxy-1,4-naphthoquinone inhibits LPS-induced BV2 microglial activation through MAPK/NF-kB signaling pathways

Author:: Hu-Nan Sun; Gui-Nan Shen; Yong-Zhe Jin; Yu Jin; Ying-Hao Han; Li Feng; Lei Liu; Mei-Hua Jin; Ying-Hua Luo; Tea-Ho Kwon; Yu-Dong Cui; Cheng-Hao Jin
Source:: Heliyon 2016 v.2 no.7 pp. e00132
ISSN:: 2405-8440
Subject:: apoptosis; cell viability; cytokines; flow cytometry; phosphorylation; therapeutics; toxicity testing
Abstract:: ... To verify the effects of several 5,8-dimethoxy-1,4-naphthoquinone (DMNQ) derivatives on LPS-induced NO production, cellular ROS levels and cytokine expression in BV-2 microglial cells.An MTT assay and FACS flow cytometry were performed to assess the cellular viability and apoptosis and cellular ROS levels, respectively. To examine the expression of pro-inflammatory cytokines and cellular signaling ...
DOI:: 10.1016/j.heliyon.2016.e00132
PubMed:: 27512726
PubMed Central:: PMC4971128
: https://doi.org/10.1016/j.heliyon.2016.e00132

41. 2015 ACVIM Small Animal Consensus Statement on Seizure Management in Dogs

Author:: M. Podell; H.A. Volk; M. Berendt; W. Löscher; K. Muñana; E.E. Patterson; S.R. Platt
Source:: Journal of veterinary internal medicine 2016 v.30 no.2 pp. 477-490
ISSN:: 0891-6640
Subject:: decision making; dogs; drug therapy; epilepsy; guidelines; monitoring; patients; quality of life; veterinary medicine
Abstract:: ... This report represents a scientific and working clinical consensus statement on seizure management in dogs based on current literature and clinical expertise. The goal was to establish guidelines for a predetermined, concise, and logical sequential approach to chronic seizure management starting with seizure identification and diagnosis (not included in this report), reviewing decision‐making, tre ...
DOI:: 10.1111/jvim.13841
PubMed:: 26899355
PubMed Central:: PMC4913615
: https://doi.org/10.1111/jvim.13841

42. 2015 Distinguished career award

Author:: Edward M. Stricker
Source:: Physiology & behavior 2016 v.162 pp. 196-200
ISSN:: 0031-9384
Subject:: adults; graduate students; memory; models
Abstract:: ... I was very pleased to receive the 2015 Distinguished Career Award from SSIB. This brief manuscript contains reminisces that might stir up pleasant memories in the older members of SSIB and also some general thoughts that I hope will be of value to the younger investigators who are closer to the beginning of their scientific careers. Although the organization has chosen to honor me with this specia ...
DOI:: 10.1016/j.physbeh.2015.09.028
PubMed:: 26434784
PubMed Central:: PMC4955950
: https://doi.org/10.1016/j.physbeh.2015.09.028

43. 25 years on and no end in sight: a perspective on the role of RecG protein

Author:: Robert G. Lloyd; Christian J. Rudolph
Source:: Current genetics 2016 v.62 no.4 pp. 827-840
ISSN:: 0172-8083
Subject:: DNA; DNA repair; DNA replication; Escherichia coli; chromosomes; crossing; homologous recombination; immunity; mutants; mutation; phenotype
Abstract:: ... The RecG protein of Escherichia coli is a double-stranded DNA translocase that unwinds a variety of branched substrates in vitro. Although initially associated with homologous recombination and DNA repair, studies of cells lacking RecG over the past 25 years have led to the suggestion that the protein might be multi-functional and associated with a number of additional cellular processes, includin ...
DOI:: 10.1007/s00294-016-0589-z
PubMed:: 27038615
PubMed Central:: PMC5055574
: https://doi.org/10.1007/s00294-016-0589-z

44. 2D-PAGE analysis of the soluble proteins of the tropical liver fluke, Fasciola gigantica and biliary amphistome, Gigantocotyle explanatum, concurrently infecting Bubalus bubalis

Author:: Yasir A. Khan; Mohd Abdul Hannan Khan; S. M. A. Abidi
Source:: Journal of parasitic diseases 2016 v.40 no.3 pp. 910-913
ISSN:: 0971-7196
Subject:: Fasciola gigantica; Paramphistomidae; buffaloes; financial economics; genes; genetic heterogeneity; habitat preferences; habitats; host-parasite relationships; isoelectric point; liver; liver flukes; molecular weight; parasitoses; polyacrylamide gel electrophoresis; polypeptides; proteins; proteomics; two-dimensional gel electrophoresis
Abstract:: ... The digenetic trematodes, Fasciola gigantica and Gigantocotyle explanatum, belonging to the family Fasciolidae and Paramphistomidae respectively, have been often found to concurrently infect the liver of Indian water buffalo Bubalus bubalis, causing serious pathological damage to the vital organ, incurring huge economic losses. In the present study the soluble gene products of both F. gigantica an ...
DOI:: 10.1007/s12639-014-0603-7
PubMed:: 27605808
PubMed Central:: PMC4996216
: https://doi.org/10.1007/s12639-014-0603-7

45. 3-Butenyl isothiocyanate: a hydrolytic product of glucosinolate as a potential cytotoxic agent against human cancer cell lines

Author:: Rohit Arora; Rakesh Kumar; Jyoti Mahajan; Adarsh P. Vig; Bikram Singh; Balbir Singh; Saroj Arora
Source:: Journal of food science and technology 2016 v.53 no.9 pp. 3437-3445
ISSN:: 0022-1155
Subject:: Brassica juncea; apoptosis; breast neoplasms; cell cycle; cytotoxicity; glucosinolates; humans; liver; membrane potential; mitochondrial membrane; neoplasm cells; osteosarcoma; prostatic neoplasms; reactive oxygen species
Abstract:: ... The present study envisages the cytotoxic potential of 3-butenyl isothiocyanate isolated from Brassica juncea L. Czern var. Pusa Jaikisan against the human cancer cell lines viz. prostate, bone osteosarcoma, cervical, liver, neuroblastoma and breast cancer. As the compound was observed to be more effective against prostate cancer cell line, therefore, this cell line was further used to study the m ...
DOI:: 10.1007/s13197-016-2316-7
PubMed:: 27777449
PubMed Central:: PMC5069244
: https://doi.org/10.1007/s13197-016-2316-7

46. 3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma

Author:: David M.G. Anderson; Raf Van de Plas; Kristie L. Rose; Salisha Hill; Kevin L. Schey; Anne C. Solga; David H. Gutmann; Richard M. Caprioli
Source:: Journal of proteomics 2016 v.149 pp. 77-84
ISSN:: 1874-3919
Subject:: children; growth and development; image analysis; mass spectrometry; mice; neoplasms; nerve tissue; vision disorders
Abstract:: ... Neurofibromatosis type 1 (NF1) is a common neurogenetic disorder, in which affected individuals develop tumors of the nervous system. Children with NF1 are particularly prone to brain tumors (gliomas) involving the optic pathway that can result in impaired vision. Since tumor formation and expansion requires a cooperative tumor microenvironment, it is important to identify the cellular and acellul ...
DOI:: 10.1016/j.jprot.2016.02.004
PubMed:: 26883872
PubMed Central:: PMC4983271
: https://doi.org/10.1016/j.jprot.2016.02.004

47. 3-D individual cell based computational modeling of tumor cell–macrophage paracrine signaling mediated by EGF and CSF-1 gradients

Author:: Hildur Knutsdottir; John S. Condeelis; Eirikur Palsson
Source:: Integrative biology 2016 v.8 no.1 pp. 104-119
ISSN:: 1757-9708
Subject:: blood vessels; in vitro studies; macrophages; mammary neoplasms (animal); metastasis; models; mortality; neoplasm cells; paracrine signaling; receptors; risk; therapeutics; women
Abstract:: ... High density of macrophages in mammary tumors has been associated with a higher risk of metastasis and thus increased mortality in women. The EGF/CSF-1 paracrine signaling increases the number of invasive tumor cells by both recruiting tumor cells further away and manipulating the macrophages' innate ability to open up a passage into blood vessels thus promoting intravasation and finally metastasi ...
DOI:: 10.1039/c5ib00201j
PubMed:: 26686751
PubMed Central:: PMC5013833
: https://doi.org/10.1039/c5ib00201j

48. 3D FSE Cube and VIPR-aTR 3.0 Tesla magnetic resonance imaging predicts canine cranial cruciate ligament structural properties

Author:: Molly Racette; Habib Al saleh; Kenneth R. Waller; Jason A. Bleedorn; Ronald P. McCabe; Ray Vanderby; Mark D. Markel; Sabrina H. Brounts; Walter F. Block; Peter Muir
Source:: veterinary journal 2016 v.209 pp. 150-155
ISSN:: 1090-0233
Subject:: clinical trials; cranial cruciate ligament; dogs; magnetic resonance imaging; models; monitoring; stifle
Abstract:: ... Estimation of cranial cruciate ligament (CrCL) structural properties in client-owned dogs with incipient cruciate rupture would be advantageous. The objective of this study was to determine whether magnetic resonance imaging (MRI) measurement of normal CrCL volume in an ex-vivo canine model predicts structural properties. Stifles from eight dogs underwent 3.0 Tesla 3D MRI. CrCL volume and normaliz ...
DOI:: 10.1016/j.tvjl.2015.10.055
PubMed:: 26831152
PubMed Central:: PMC5506841
: https://doi.org/10.1016/j.tvjl.2015.10.055

49. 3D RNA and Functional Interactions from Evolutionary Couplings

Author:: Caleb Weinreb; Adam J. Riesselman; John B. Ingraham; Torsten Gross; Chris Sander; Debora S. Marks
Source:: Cell 2016 v.165 pp. 963-975
ISSN:: 0092-8674
Subject:: Human immunodeficiency virus; models; non-coding RNA; nucleotide sequences; prediction; probability; protein structure
Abstract:: ... Non-coding RNAs are ubiquitous, but the discovery of new RNA gene sequences far outpaces the research on the structure and functional interactions of these RNA gene sequences. We mine the evolutionary sequence record to derive precise information about the function and structure of RNAs and RNA-protein complexes. As in protein structure prediction, we use maximum entropy global probability models ...
DOI:: 10.1016/j.cell.2016.03.030
PubMed:: 27087444
PubMed Central:: PMC5024353
: https://doi.org/10.1016/j.cell.2016.03.030

50. 3D Raman imaging of systemic endothelial dysfunction in the murine model of metastatic breast cancer

Author:: Marta Z. Pacia; Elzbieta Buczek; Agnieszka Blazejczyk; Aleksandra Gregorius; Joanna Wietrzyk; Stefan Chlopicki; Malgorzata Baranska; Agnieszka Kaczor
Source:: Analytical and bioanalytical chemistry 2016 v.408 no.13 pp. 3381-3387
ISSN:: 1618-2642
Subject:: animal models; aorta; breast neoplasms; endothelium; image analysis; lipid content; lipids; metastasis; nitric oxide; protein content
Abstract:: ... It was recently reported in the murine model of metastatic breast cancer (4T1) that tumor progression and development of metastasis is associated with systemic endothelial dysfunction characterized by impaired nitric oxide (NO) production. Using Raman 3D confocal imaging with the analysis of the individual layers of the vascular wall combined with AFM endothelial surface imaging, we demonstrated t ...
DOI:: 10.1007/s00216-016-9436-9
PubMed:: 26935932
PubMed Central:: PMC4837206
: https://doi.org/10.1007/s00216-016-9436-9

51. 3D bioprinting for engineering complex tissues

Author:: Christian Mandrycky; Zongjie Wang; Keekyoung Kim; Deok-Ho Kim
Source:: Biotechnology advances 2016 v.34 no.4 pp. 422-434
ISSN:: 0734-9750
Subject:: biocompatible materials; bioprinting; cartilage; drugs; humans; innervation; medicine; models; screening; stem cells
Abstract:: ... Bioprinting is a 3D fabrication technology used to precisely dispense cell-laden biomaterials for the construction of complex 3D functional living tissues or artificial organs. While still in its early stages, bioprinting strategies have demonstrated their potential use in regenerative medicine to generate a variety of transplantable tissues, including skin, cartilage, and bone. However, current b ...
DOI:: 10.1016/j.biotechadv.2015.12.011
PubMed:: 26724184
PubMed Central:: PMC4879088
: https://doi.org/10.1016/j.biotechadv.2015.12.011

52. 3D brown adipogenesis to create “Brown-Fat-in-Microstrands”

Author:: Andrea M. Unser; Bridget Mooney; David T. Corr; Yu-Hua Tseng; Yubing Xie
Source:: Biomaterials 2016 v.75 pp. 123-134
ISSN:: 0142-9612
Subject:: adipocytes; beta-adrenergic agonists; quantitative polymerase chain reaction; cell culture; hydrocolloids; heat; models; encapsulation; gene expression; metabolic diseases; mice; embryonic stem cells; obesity; energy balance; immunocytochemistry; adipogenesis
Abstract:: ... The ability of brown adipocytes (fat cells) to dissipate energy as heat shows great promise for the treatment of obesity and other metabolic disorders. Employing pluripotent stem cells, with an emphasis on directed differentiation, may overcome many issues currently associated with primary fat cell cultures. In addition, three-dimensional (3D) cell culture systems are needed to better understand t ...
DOI:: 10.1016/j.biomaterials.2015.10.017
PubMed:: 26496384
PubMed Central:: PMC4644497
: https://doi.org/10.1016/j.biomaterials.2015.10.017

53. 3D nanostructured inkjet printed graphene via UV-pulsed laser irradiation enables paper-based electronics and electrochemical devices

Author:: Das Suprem R.; Nian Qiong; Cargill Allison A.; Hondred John A.; Ding Shaowei; Saei Mojib; Cheng Gary J.; Claussen Jonathan C.
Source:: Nanoscale pp. -
ISSN:: 2040-3364
Subject:: biosensors; electrical conductivity; electrochemistry; electronics; films (materials); graphene; graphene oxide; heat; hydrogen peroxide; irradiation; paper; voltammetry
Abstract:: ... Emerging research on printed and flexible graphene-based electronics is beginning to show tremendous promise for a wide variety of fields including wearable sensors and thin film transistors. However, post-print annealing/reduction processes that are necessary to increase the electrical conductivity of the printed graphene degrade sensitive substrates (e.g., paper) and are whole substrate processe ...
DOI:: 10.1039/c6nr04310k
CHORUS:: 10.1039/c6nr04310k
: https://doi.org/10.1039/c6nr04310k

54. 3D porous chitosan–alginate scaffolds promote proliferation and enrichment of cancer stem-like cells

Author:: Stephen J. FlorczykThese authors contributed equally to the work.Current Address: Department of Materials Science & Engineering, University of Central Florida, Orlando, FL 32816-2455, USA.; Forrest M. Kievit; Kui Wang; Ariane E. Erickson; Richard G. Ellenbogen; Miqin Zhang
Source:: Journal of materials chemistry B 2016 v.4 no.38 pp. 6326-6334
ISSN:: 2050-7518
Subject:: breast neoplasms; cell lines; genes; glioblastoma; liver; stem cells
Abstract:: ... Cancer stem cells are increasingly becoming a primary target for new cancer treatment development. The ability to study their transient behavior in vitro will provide the opportunity for high-throughput testing of more effective therapies. We have previously demonstrated the use of 3D porous chitosan–alginate (CA) scaffolds to promote cancer stem-like cell (CSC) proliferation and enrichment in gli ...
DOI:: 10.1039/c6tb01713d
PubMed:: 28133535
PubMed Central:: PMC5260821
: https://doi.org/10.1039/c6tb01713d

55. 3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin

Author:: Daniel G. Booth; Alison J. Beckett; Oscar Molina; Itaru Samejima; Hiroshi Masumoto; Natalay Kouprina; Vladimir Larionov; Ian A. Prior; William C. Earnshaw
Source:: Molecular cell 2016 v.64 no.4 pp. 790-802
ISSN:: 1097-2765
Subject:: chromatin; chromosome number; metaphase; mitosis; models; prophase; proteomics; scanning electron microscopy
Abstract:: ... Recent studies have revealed the importance of Ki-67 and the chromosome periphery in chromosome structure and segregation, but little is known about this elusive chromosome compartment. Here we used correlative light and serial block-face scanning electron microscopy, which we term 3D-CLEM, to model the entire mitotic chromosome complement at ultra-structural resolution. Prophase chromosomes exhib ...
DOI:: 10.1016/j.molcel.2016.10.009
PubMed:: 27840028
PubMed Central:: PMC5128728
: https://doi.org/10.1016/j.molcel.2016.10.009

56. 3D-printed microfluidic devices: fabrication, advantages and limitations—a mini review

Author:: Chengpeng Chen; Benjamin T. Mehl; Akash S. Munshi; Alexandra D. Townsend; Dana M. Spence; R. Scott Martin
Source:: Analytical methods 2016 v.8 no.31 pp. 6005-6012
ISSN:: 1759-9679
Subject:: analytical methods; equipment design; microfluidic technology; printers
Abstract:: ... A mini-review with 79 references. In this review, the most recent trends in 3D-printed microfluidic devices are discussed. In addition, a focus is given to the fabrication aspects of these devices, with the ESI containing detailed instructions for designing a variety of structures including: a microfluidic channel, threads to accommodate commercial fluidic fittings, a flow splitter; a well plate, ...
DOI:: 10.1039/c6ay01671e
PubMed:: 27617038
PubMed Central:: PMC5012532
: https://doi.org/10.1039/c6ay01671e

57. 3D-printed supercapacitor-powered electrochemiluminescent protein immunoarray

Author:: Karteek Kadimisetty; Islam M. Mosa; Spundana Malla; Jennifer E. Satterwhite-Warden; Tyler M. Kuhns; Ronaldo C. Faria; Norman H. Lee; James F. Rusling
Source:: Biosensors & bioelectronics 2016 v.77 pp. 188-193
ISSN:: 0956-5663
Subject:: antigens; biomarkers; blood serum; calves; cameras; carbon; detection limit; diagnostic techniques; electrochemistry; enzyme-linked immunosorbent assay; gravity; immunosensors; nanoparticles; oxidation; patients; photovoltaic cells; prostatic neoplasms; silica; washing
Abstract:: ... Herein we report a low cost, sensitive, supercapacitor-powered electrochemiluminescent (ECL) protein immunoarray fabricated by an inexpensive 3-dimensional (3D) printer. The immunosensor detects three cancer biomarker proteins in serum within 35min. The 3D-printed device employs hand screen printed carbon sensors with gravity flow for sample/reagent delivery and washing. Prostate cancer biomarker ...
DOI:: 10.1016/j.bios.2015.09.017
PubMed:: 26406460
PubMed Central:: PMC4673015
: https://doi.org/10.1016/j.bios.2015.09.017

58. 3DRobot: automated generation of diverse and well-packed protein structure decoys

Author:: Haiyou Deng; Ya Jia; Yang Zhang
Source:: Bioinformatics 2016 v.32 no.3 pp. 378-387
ISSN:: 1460-2059
Subject:: algorithms; automation; bioinformatics; energy; hydrogen bonding; models; protein folding; proteins
Abstract:: ... Motivation: Computationally generated non-native protein structure conformations (or decoys) are often used for designing protein folding simulation methods and force fields. However, almost all the decoy sets currently used in literature suffer from uneven root mean square deviation (RMSD) distribution with bias to non-protein like hydrogen-bonding and compactness patterns. Meanwhile, most protei ...
DOI:: 10.1093/bioinformatics/btv601
PubMed:: 26471454
PubMed Central:: PMC5006309
: https://doi.org/10.1093/bioinformatics/btv601

59. 3DSEM: A 3D microscopy dataset

Author:: Ahmad P. Tafti; Andrew B. Kirkpatrick; Jessica D. Holz; Heather A. Owen; Zeyun Yu
Source:: Data in Brief 2016 v.6 pp. 112-116
ISSN:: 2352-3409
Subject:: data collection; models; vision
Abstract:: ... The Scanning Electron Microscope (SEM) as a 2D imaging instrument has been widely used in many scientific disciplines including biological, mechanical, and materials sciences to determine the surface attributes of microscopic objects. However the SEM micrographs still remain 2D images. To effectively measure and visualize the surface properties, we need to truly restore the 3D shape model from 2D ...
DOI:: 10.1016/j.dib.2015.11.018
PubMed:: 26779561
PubMed Central:: PMC4685174
: https://doi.org/10.1016/j.dib.2015.11.018

60. 4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?

Author:: Monika Sekelja; Jonas Paulsen; Philippe Collas
Source:: Genome biology 2016 v.17 no.1 pp. 54
ISSN:: 1474-760X
Subject:: chromatin; genome; models
Abstract:: ... Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome in single cells versus ensembles of cells and assess their underlying assumptions. We further address approaches to study the spatio-temporal aspects of genome organization from s ...
DOI:: 10.1186/s13059-016-0923-2
PubMed:: 27052789
PubMed Central:: PMC4823877
: https://doi.org/10.1186/s13059-016-0923-2

61. 5,7-Dimethoxycoumarin prevents chronic mild stress induced depression in rats through increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels

Author:: Wei Yang; Huanlin Wang
Source:: Saudi Journal of Biological Sciences 2016 pp. -
ISSN:: 1319-562X
Subject:: amine oxidase (flavin-containing); animal models; caspase-3; heat stress; hippocampus; locomotion; messenger RNA; proteins; rats; tissues
Abstract:: ... The current study was aimed to investigate the role of 5,7-dimethoxycoumarin in the prevention of chronic mild stress induced depression in rats. The chronic mild stress rat model was prepared using the known protocols. The results from open-field test showed that rats in the chronic mild stress group scored very low in terms of crossings and rearings than those of the normal rats. However, pre-tr ...
DOI:: 10.1016/j.sjbs.2016.10.016
PubMed:: 29472774
PubMed Central:: PMC5815981
: https://doi.org/10.1016/j.sjbs.2016.10.016

62. 5-Hydroxymethylcytosine in E-box motifs ACATGTG and ACACGTG increases DNA-binding of the B-HLH transcription factor TCF4

Author:: Syed Khund-Sayeed; Ximiao He; Timothy Holzberg; Jun Wang; Divya Rajagopal; Shriyash Upadhyay; Stewart R. Durell; Sanjit Mukherjee; Matthew T. Weirauch; Robert Rose; Charles Vinson
Source:: Integrative biology 2016 v.8 no.9 pp. 936-945
ISSN:: 1757-9708
Subject:: DNA; DNA probes; X-radiation; cytosine; landscapes; microarray technology; nucleotide sequences; protein binding; transcription factors
Abstract:: ... We evaluated DNA binding of the B-HLH family members TCF4 and USF1 using protein binding microarrays (PBMs) containing double-stranded DNA probes with cytosine on both strands or 5-methylcytosine (5mC) or 5-hydroxymethylcytosine (5hmC) on one DNA strand and cytosine on the second strand. TCF4 preferentially bound the E-box motif (CANNTG) with strongest binding to the 8-mer CAGGTGGT. 5mC uniformly ...
DOI:: 10.1039/c6ib00079g
PubMed:: 27485769
PubMed Central:: PMC6289052
: https://doi.org/10.1039/c6ib00079g

63. 53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms

Author:: Raquel Cuella-Martin; Catarina Oliveira; Helen E. Lockstone; Suzanne Snellenberg; Natalia Grolmusova; J. Ross Chapman
Source:: Molecular cell 2016 v.64 no.1 pp. 51-64
ISSN:: 1097-2765
Subject:: DNA; DNA repair; cell cycle; genes; ionizing radiation; proteinases; transcriptional activation; tumor suppressor proteins
Abstract:: ... The tumor suppressor protein 53BP1, a pivotal regulator of DNA double-strand break (DSB) repair, was first identified as a p53-interacting protein over two decades ago. However, its direct contributions to p53-dependent cellular activities remain undefined. Here, we reveal that 53BP1 stimulates genome-wide p53-dependent gene transactivation and repression events in response to ionizing radiation ( ...
DOI:: 10.1016/j.molcel.2016.08.002
PubMed:: 27546791
PubMed Central:: PMC5065530
: https://doi.org/10.1016/j.molcel.2016.08.002

64. 6-shogaol attenuates H2O2-induced oxidative stress via upregulation of Nrf2-mediated γ-glutamylcysteine synthetase and heme oxygenase expression in HepG2 cells

Author:: Jin-Kyoung Kim; Hae-Dong Jang
Source:: Food science and biotechnology 2016 v.25 no.1 pp. 319-327
ISSN:: 1226-7708
Subject:: Western blotting; antioxidant activity; antioxidants; glutamate-cysteine ligase; heme oxygenase (biliverdin-producing); human cell lines; metabolic detoxification; mitogen-activated protein kinase; oxidative stress; signal transduction
Abstract:: ... The signaling pathway by which 6-shogaol protects HepG2 cells against H₂O₂-induced oxidative stress was investigated. Cellular anti-oxidant activities, the GSH level, and anti-oxidant response element (ARE) promoter activity were analyzed. Activated protein kinases and nuclear transcription factor-erythroid 2-related factor 2 (Nrf2) accumulation in the nucleus, and phase II detoxification and anti ...
DOI:: 10.1007/s10068-016-0045-3
PubMed:: 30263273
PubMed Central:: PMC6049361
: https://doi.org/10.1007/s10068-016-0045-3

65. 7SKiing on chromatin: Move globally, act locally

Author:: Iván D'Orso
Source:: RNA biology 2016 v.13 no.6 pp. 545-553
ISSN:: 1555-8584
Subject:: DNA-directed RNA polymerase; chromatin; models; peptide elongation factors; transcription (genetics)
Abstract:: ... RNA polymerase II (Pol II) pausing at promoter-proximal regions is a highly regulated step in the transcription cycle. Pause release is facilitated by the P-TEFb kinase, which phosphorylates Pol II and negative elongation factors. Recent studies suggest that P-TEFb (as part of the inhibitory 7SK snRNP) is recruited to promoter-proximal regions through interaction with KAP1/TRIM28/TIF1β to facilita ...
DOI:: 10.1080/15476286.2016.1181254
PubMed:: 27128603
PubMed Central:: PMC4962805
: https://doi.org/10.1080/15476286.2016.1181254

66. 9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages

Author:: Sapir Bechor; Noa Zolberg Relevy; Ayelet Harari; Tal Almog; Yehuda Kamari; Ami Ben-Amotz; Dror Harats; Aviv Shaish
Source:: Nutrients 2016 v.8 no.7 pp. -
ISSN:: 2072-6643
Subject:: Dunaliella; algae; apolipoprotein E; atherogenesis; atherosclerosis; beta-carotene; cholesterol; diet; food fortification; gene expression; high density lipoprotein; macrophages; messenger RNA; mice; protein content; transcription (genetics); transporters
Abstract:: ... Cholesterol efflux from macrophages is a key process in reverse cholesterol transport and, therefore, might inhibit atherogenesis. 9-cis-β-carotene (9-cis-βc) is a precursor for 9-cis-retinoic-acid (9-cis-RA), which regulates macrophage cholesterol efflux. Our objective was to assess whether 9-cis-βc increases macrophage cholesterol efflux and induces the expression of cholesterol transporters. En ...
DOI:: 10.3390/nu8070435
PubMed:: 27447665
PubMed Central:: PMC4963911
: https://doi.org/10.3390/nu8070435

67. 9-Fluorenylmethyl (Fm) Disulfides: Biomimetic Precursors for Persulfides

Author:: Park Chung-Min; Johnson Brett A.; Duan Jicheng; Park Jeong-Jin; Day Jacob J.; Gang David; Qian Wei-Jun; Xian Ming
Source:: Organic letters 2016 v.18 no.5 pp. 904-907
ISSN:: 1523-7052
Subject:: Lewis bases; biomimetics; chemical reactions; chemical structure; sulfides; thiols
Abstract:: ... The development of a functional disulfide, FmSSPy-A (Fm = 9-fluorenylmethyl; Py = pyridinyl), is reported. It can effectively convert small molecule and protein thiols (−SH) to form −S-SFm adducts under mild conditions. This method allows for a H₂S-free and biomimetic protocol to generate highly reactive persulfides (in their anionic forms). The high nucleophilicity of persulfides toward a number ...
DOI:: 10.1021/acs.orglett.5b03557
PubMed:: 26870874
PubMed Central:: PMC4782721
: https://doi.org/10.1021/acs.orglett.5b03557

68. Lactobacillus fermentum CRL1446 Ameliorates Oxidative and Metabolic Parameters by Increasing Intestinal Feruloyl Esterase Activity and Modulating Microbiota in Caloric-Restricted Mice

Author:: Matias Russo; Emanuel Fabersani; María C. Abeijón-Mukdsi; Romina Ross; Cecilia Fontana; Alfonso Benítez-Páez; Paola Gauffin-Cano; Roxana B. Medina
Source:: Nutrients 2016 v.8 no.7 pp. -
ISSN:: 2072-6643
Subject:: Bacteroidetes; Bifidobacterium; Lactobacillus fermentum; ad libitum feeding; cholesterol; diet; enzyme activity; feruloyl esterase; genes; glucose; glutathione-disulfide reductase; high-throughput nucleotide sequencing; intestinal microorganisms; intestinal mucosa; males; mice; ribosomal RNA; thiobarbituric acid-reactive substances; triacylglycerols
Abstract:: ... The purpose of this study was to determine whether the administration of the feruloyl esterase (FE)-producing strain Lactobacillus fermentum CRL1446 enhances metabolic and oxidative parameters in caloric-restricted (CR) mice. Balb/c male mice were divided into ad libitum fed Group (ALF Group), CR diet Group (CR Group) and CR diet plus L. fermentum Group (CR-Lf Group). CR diet was administered duri ...
DOI:: 10.3390/nu8070415
PubMed:: 27399766
PubMed Central:: PMC4963891
: https://doi.org/10.3390/nu8070415

69. Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice

Author:: Yi-Ming Chen; Li Wei; Yen-Shuo Chiu; Yi-Ju Hsu; Tsung-Yu Tsai; Ming-Fu Wang; Chi-Chang Huang
Source:: Nutrients 2016 v.8 no.4 pp. -
ISSN:: 2072-6643
Subject:: Lactobacillus plantarum; albumins; ammonia; athletic performance; blood serum; body weight; creatine kinase; creatinine; energy; exercise; glucose; health promotion; intestinal microorganisms; lactic acid; males; mice; muscle tissues; muscles; oral administration; probiotics; swimming; triacylglycerols; urea nitrogen
Abstract:: ... Lactobacillus plantarum (L. plantarum) is a well-known probiotic among the ingested-microorganism probiotics (i.e., ingested microorganisms associated with beneficial effects for the host). However, few studies have examined the effects of L. plantarum TWK10 (LP10) supplementation on exercise performance, physical fatigue, and gut microbial profile. Male Institute of Cancer Research (ICR) strain m ...
DOI:: 10.3390/nu8040205
PubMed:: 27070637
PubMed Central:: PMC4848674
: https://doi.org/10.3390/nu8040205

70. Lariophagus distinguendus (Hymenoptera: Pteromalidae) (Förster)—Past, Present, and Future: The History of a Biological Control Method Using L. distinguendus against Different Storage Pests

Author:: Steffi Niedermayer; Marie Pollmann; Johannes L. M. Steidle
Source:: Insects 2016 v.7 no.3 pp. -
ISSN:: 2075-4450
Subject:: Lariophagus distinguendus; Sitophilus granarius; Sitophilus oryzae; biological control agents; biological pest control; grain storage facilities; insecticides; rearing; storage pests; wasps
Abstract:: ... Legal requirements and consumer demands for residue-free products pose a big challenge for pest control in grain stores. One possible alternative to chemical insecticides is biological pest control with the pteromalid wasp Lariophagus distinguendus against the weevils Sitophilus granarius, S. oryzae (Coleoptera: Dryophtoridae), and many other storage pest beetles. The use of this wasp as a biocont ...
DOI:: 10.3390/insects7030039
PubMed:: 27490572
PubMed Central:: PMC5039552
: https://doi.org/10.3390/insects7030039

71. Lycopersicon esculentum Extract Enhances Cognitive Function and Hippocampal Neurogenesis in Aged Mice

Author:: Jung-Soo Bae; Mira Han; Hee Soon Shin; Dong-Hwa Shon; Soon-Tae Lee; Chang-Yup Shin; Yuri Lee; Dong Hun Lee; Jin Ho Chung
Source:: Nutrients 2016 v.8 no.11 pp. -
ISSN:: 2072-6643
Subject:: Solanum lycopersicum var. lycopersicum; adults; cognition; fruits; hippocampus; memory disorders; mice; mitogen-activated protein kinase; neurodegenerative diseases; neurogenesis; nutrients; oral administration; signal transduction; synapse; tomatoes
Abstract:: ... A decrease in adult neurogenesis is associated with the aging process, and this decrease is closely related to memory impairment. Tomato (Lycopersicon esculentum) is a fruit with diverse bioactive nutrients that is consumed worldwide. In this study, we investigated the cognition-enhancing effect of tomato ethanolic extracts (TEE) in aged mice. Six weeks of oral TEE administration in 12-month-old a ...
DOI:: 10.3390/nu8110679
PubMed:: 27792185
PubMed Central:: PMC5133067
: https://doi.org/10.3390/nu8110679

72. MADD-FOLH1 Polymorphisms and Their Haplotypes with Serum Lipid Levels and the Risk of Coronary Heart Disease and Ischemic Stroke in a Chinese Han Population

Author:: Dong-Feng Wu; Rui-Xing Yin; Xiao-Li Cao; Feng Huang; Jin-Zhen Wu; Wu-Xian Chen
Source:: Nutrients 2016 v.8 no.4 pp. -
ISSN:: 2072-6643
Subject:: Chinese people; alcohol drinking; blood lipids; blood serum; body mass index; coronary disease; gene frequency; genetic models; genotyping; haplotypes; high density lipoprotein cholesterol; low density lipoprotein cholesterol; patients; single nucleotide polymorphism; smoking (habit); stroke; triacylglycerols
Abstract:: ... This study aimed to detect the association of the MADD-FOLH1 single nucleotide polymorphisms (SNPs) and their haplotypes with the risk of coronary heart disease (CHD) and ischemic stroke (IS) in a Chinese Han population. Six SNPs of rs7395662, rs326214, rs326217, rs1051006, rs3736101, and rs7120118 were genotyped in 584 CHD and 555 IS patients, and 596 healthy controls. The genotypic and allelic f ...
DOI:: 10.3390/nu8040208
PubMed:: 27070640
PubMed Central:: PMC4848677
: https://doi.org/10.3390/nu8040208

73. N-3 Polyunsaturated Fatty Acids Improve Liver Lipid Oxidation-Related Enzyme Levels and Increased the Peroxisome Proliferator-Activated Receptor α Expression Level in Mice Subjected to Hemorrhagic Shock/Resuscitation

Author:: Li Zhang; Feng Tian; Xuejin Gao; Xinying Wang; Chao Wu; Ning Li; Jieshou Li
Source:: Nutrients 2016 v.8 no.4 pp. -
ISSN:: 2072-6643
Subject:: Western blotting; blood serum; carnitine palmitoyltransferase; fatty acid transport proteins; fish oils; gene expression; liver; mice; omega-3 fatty acids; peroxisome proliferator-activated receptor alpha; polyunsaturated fatty acids; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; surgery; tissues; triacylglycerols
Abstract:: ... Appropriate metabolic interventions after hemorrhagic shock/resuscitation injury have not yet been identified. We aimed to examine the effects of fish oil on lipid metabolic intervention after hemorrhagic shock/resuscitation. Firstly, 48 C57BL/6 mice were assigned to six groups (n = 8 per group). The sham group did not undergo surgery, while mice in the remaining groups were sacrificed 1–5 days af ...
DOI:: 10.3390/nu8040237
PubMed:: 27110821
PubMed Central:: PMC4848705
: https://doi.org/10.3390/nu8040237

74. Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress

Author:: Amel M. Soliman; Shreen Desouky; Mohamed Marzouk; Amany A. Sayed
Source:: Nutrients 2016 v.8 no.5 pp. -
ISSN:: 2072-6643
Subject:: Origanum majorana; antioxidant activity; blood; body weight; catalase; cisplatin; creatinine; drug therapy; free radical scavengers; glutathione; males; malondialdehyde; neoplasms; nephrotoxicity; nitric oxide; oxidative stress; plant extracts; rats; superoxide dismutase; urea; urea nitrogen; uric acid
Abstract:: ... Despite the fact that cisplatin is an important anticancer drug, its clinical utilization is limited by nephrotoxicity during long term medication. Combined cisplatin chemotherapy with plant extracts can diminish toxicity and enhance the antitumor efficacy of the drug. This study evaluated the effect of Originum majorana ethanolic extract (OMEE) on cisplatin-induced nephrotoxicity. Eighteen male r ...
DOI:: 10.3390/nu8050264
PubMed:: 27164131
PubMed Central:: PMC4882677
: https://doi.org/10.3390/nu8050264

75. Platycodon grandiflorus Root Extract Attenuates Body Fat Mass, Hepatic Steatosis and Insulin Resistance through the Interplay between the Liver and Adipose Tissue

Author:: Ye Jin Kim; Ji-Young Choi; Ri Ryu; Jeonghyeon Lee; Su-Jung Cho; Eun-Young Kwon; Mi-Kyung Lee; Kwang-Hyeon Liu; Yu Rina; Mi-Kyung Sung; Myung-Sook Choi
Source:: Nutrients 2016 v.8 no.9 pp. -
ISSN:: 2072-6643
Subject:: Platycodon grandiflorus; adipocytes; adiponectin; beta oxidation; body fat; body weight changes; diabetes; energy expenditure; ethanol; fatty liver; functional foods; gene expression; gene expression regulation; genes; glucose; high fat diet; insulin resistance; leptin; lipids; lipogenesis; liver; males; mice; obesity; peroxisome proliferator-activated receptor alpha; peroxisome proliferator-activated receptor gamma; white adipose tissue
Abstract:: ... The Platycodon grandiflorus root, a Korean medicinal food, is well known to have beneficial effects on obesity and diabetes. In this study, we demonstrated the metabolic effects of P. grandiflorus root ethanol extract (PGE), which is rich in platycodins, on diet-induced obesity. C57BL/6J mice (four-week-old males) were fed a normal diet (16.58% of kilocalories from fat), high-fat diet (HFD, 60% of ...
DOI:: 10.3390/nu8090532
PubMed:: 27589792
PubMed Central:: PMC5037519
: https://doi.org/10.3390/nu8090532

76. Psoralea corylifolia L. Seed Extract Attenuates Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice

Author:: Eunhui Seo; Yoon Sin Oh; Hee-Sook Jun
Source:: Nutrients 2016 v.8 no.2 pp. -
ISSN:: 2072-6643
Subject:: Cullen corylifolium; adipose tissue; animal disease models; blood glucose; blood lipids; fatty liver; genes; glucose tolerance; high fat diet; inflammation; insulin resistance; liver; mice; obesity; seed extracts; therapeutics; triacylglycerols
Abstract:: ... Nonalcoholic fatty liver disease (NAFLD), along with obesity, is increasing world-wide and is one of the major causes of chronic hepatic disease. The present study evaluated the ameliorative effect of extract of Psoralea corylifolia L. seed (PCS) on high fat diet-induced NAFLD in C57BL/6 mice after daily administration at 300 or 500 mg/kg for 12 weeks. Treatment with PCS extract significantly redu ...
DOI:: 10.3390/nu8020083
PubMed:: 26861390
PubMed Central:: PMC4772046
: https://doi.org/10.3390/nu8020083

77. Allomyrina Dichotoma Larvae Regulate Food Intake and Body Weight in High Fat Diet-Induced Obese Mice Through mTOR and Mapk Signaling Pathways

Author:: Jongwan Kim; Eun-Young Yun; Seong-Won Park; Tae-Won Goo; Minchul Seo
Source:: Nutrients 2016 v.8 no.2 pp. -
ISSN:: 2072-6643
Subject:: Trypoxylus dichotomus; adipocytes; animal disease models; antibacterial properties; bioactive compounds; endoplasmic reticulum; ethanol; feeding behavior; food intake; hypothalamus; larvae; mice; mitogen-activated protein kinase; obesity; signal transduction; traditional medicine
Abstract:: ... Recent evidence has suggested that the Korean horn beetle (Allomyrina dichotoma) has anti-hepatofibrotic, anti-neoplastic, and antibiotic effects and is recognized as a traditional medicine. In our previous works, Allomyrina dichotoma larvae (ADL) inhibited differentiation of adipocytes both in vitro and in vivo. However, the anorexigenic and endoplasmic reticulum(ER) stress-reducing effects of AD ...
DOI:: 10.3390/nu8020100
PubMed:: 26901224
PubMed Central:: PMC4772062
: https://doi.org/10.3390/nu8020100

78. In Vitro Bioaccessibility of Phenolic Acids from a Commercial Aleurone-Enriched Bread Compared to a Whole Grain Bread

Author:: Margherita Dall’Asta; Letizia Bresciani; Luca Calani; Marta Cossu; Daniela Martini; Camilla Melegari; Daniele Del Rio; Nicoletta Pellegrini; Furio Brighenti; Francesca Scazzina
Source:: Nutrients 2016 v.8 no.1 pp. -
ISSN:: 2072-6643
Subject:: Triticum; bioavailability; breads; in vitro digestion; ingredients; phenolic acids; wheat; whole grain foods
Abstract:: ... Wheat aleurone, due to its potentially higher bioaccessibility and bioavailability of micronutrients and phenolic acids, could represent a useful ingredient in the production of commonly consumed cereal-based food. The aim of the present study was to investigate the in vitro bioaccessibility of phenolic acids both from an aleurone-enriched bread and from a whole grain bread. The two bread samples ...
DOI:: 10.3390/nu8010042
PubMed:: 26771635
PubMed Central:: PMC4728655
: https://doi.org/10.3390/nu8010042

79. Lactobacillus fermentum Suo Attenuates HCl/Ethanol Induced Gastric Injury in Mice through Its Antioxidant Effects

Author:: Huayi Suo; Xin Zhao; Yu Qian; Peng Sun; Kai Zhu; Jian Li; Baozhong Sun
Source:: Nutrients 2016 v.8 no.3 pp. -
ISSN:: 2072-6643
Subject:: Lactobacillus fermentum; antioxidant activity; blood serum; catalase; endothelial nitric oxide synthase; epidermal growth factor; epidermal growth factor receptors; ethanol; gastric juice; glutathione peroxidase; hydrochloric acid; hydrophobicity; inducible nitric oxide synthase; interferon-gamma; interleukin-12; interleukin-6; intragastric administration; malondialdehyde; messenger RNA; mice; molecular biology; motilin; neuronal nitric oxide synthase; nitric oxide; occludins; pH; probiotics; reverse transcriptase polymerase chain reaction; somatostatin; substance P; superoxide dismutase; tissues; transcription factor NF-kappa B; tumor necrosis factor-alpha; tyrosine; vascular endothelial growth factors; vasoactive intestinal peptide
Abstract:: ... The purpose of the study was to determine the inhibitory effects of Lactobacillus fermentum Suo (LF-Suo) on HCl/ethanol induced gastric injury in ICR (Institute for Cancer Research) mice and explain the mechanism of these effects through the molecular biology activities of LF-Suo. The studied mice were divided into four groups: healthy, injured, LF-Suo-L and LF-Suo-H group. After the LF-Suo intrag ...
DOI:: 10.3390/nu8030155
PubMed:: 26978395
PubMed Central:: PMC4808883
: https://doi.org/10.3390/nu8030155

80. n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease

Author:: Anne Barden; Nathan O’Callaghan; Valerie Burke; Emile Mas; Lawrence J. Beilin; Michael Fenech; Ashley B. Irish; Gerald F. Watts; Ian B. Puddey; Rae-Chi Huang; Trevor A. Mori
Source:: Nutrients 2016 v.8 no.3 pp. -
ISSN:: 2072-6643
Subject:: DNA; blood plasma; cardiovascular diseases; coenzyme Q10; kidney diseases; mononuclear leukocytes; neutrophils; normal values; olive oil; omega-3 fatty acids; oxidative stress; patients; telomeres
Abstract:: ... DNA telomere shortening associates with the age-related increase cardiovascular disease (CVD) risk. Reducing oxidative stress, could modify telomere erosion during cell replication, and CVD risk in patients with chronic kidney disease (CKD). The effect of n-3 fatty acids and coenzyme Q10 (CoQ) on telomere length was studied in a double-blind placebo-controlled trial in CKD. Eighty-five CKD patient ...
DOI:: 10.3390/nu8030175
PubMed:: 27007392
PubMed Central:: PMC4808901
: https://doi.org/10.3390/nu8030175

81. A 0.5-Mbp deletion on bovine chromosome 23 is a strong candidate for stillbirth in Nordic Red cattle

Author:: Goutam Sahana; Terhi Iso-Touru; Xiaoping Wu; Ulrik Sander Nielsen; Dirk-Jan de Koning; Mogens Sandø Lund; Johanna Vilkki; Bernt Guldbrandtsen
Source:: Genetics, selection, evolution 2016 v.48 no.1 pp. 35
ISSN:: 0999-193X
Subject:: alleles; bulls; carrier state; chromosomes; dairy cattle; fetal death; haplotypes; high-throughput nucleotide sequencing; homozygosity; inheritance (genetics); quantitative trait loci; single nucleotide polymorphism; sires
Abstract:: ... BACKGROUND: A whole-genome association study of 4631 progeny-tested Nordic Red dairy cattle bulls using imputed next-generation sequencing data revealed a major quantitative trait locus (QTL) that affects birth index (BI) on Bos taurus autosome (BTA) 23. We analyzed this QTL to identify which of the component traits of BI are affected and understand its molecular basis. RESULTS: A genome-wide scan ...
DOI:: 10.1186/s12711-016-0215-z
PubMed:: 27091210
PubMed Central:: PMC4835938
: https://doi.org/10.1186/s12711-016-0215-z

82. A 10-day vacancy period after cleaning and disinfection has no effect on the bacterial load in pig nursery units

Author:: K. Luyckx; S. Millet; S. Van Weyenberg; L. Herman; M. Heyndrickx; J. Dewulf; K. De Reu
Source:: BMC veterinary research 2016 v.12 no.1 pp. 236
ISSN:: 1746-6148
Subject:: Enterococcus; Escherichia coli; biosecurity; cleaning; coliform bacteria; disease outbreaks; disinfection; drinking; environmental impact; farms; flora; livestock and meat industry; methicillin-resistant Staphylococcus aureus; microbial load; microbiological quality; swine
Abstract:: ... BACKGROUND: Biosecurity measures such as cleaning, disinfection and a vacancy period between production cycles on pig farms are essential to prevent disease outbreaks. No studies have tested the effect of a longer vacancy period on bacterial load in nursery units. METHODS: The present study evaluated the effect of a 10-day vacancy period in pig nursery units on total aerobic flora, Enterococcus sp ...
DOI:: 10.1186/s12917-016-0850-1
PubMed:: 27760542
PubMed Central:: PMC5069936
: https://doi.org/10.1186/s12917-016-0850-1

83. A 10-year study of Alternaria and Cladosporium in two Polish cities (Szczecin and Cracow) and relationship with the meteorological parameters

Author:: Agnieszka Grinn-Gofroń; Agnieszka Strzelczak; Danuta Stępalska; Dorota Myszkowska
Source:: Aerobiologia 2016 v.32 no.1 pp. 83-94
ISSN:: 0393-5965
Subject:: Alternaria; Cladosporium; air temperature; allergenicity; bioaerosols; cities; correspondence analysis; fungal spores; models; relative humidity; temperate zones; wind speed; Poland
Abstract:: ... Alternaria and Cladosporium spores belong to the most frequent and allergenic particles in bioaerosol in the temperate climate. The investigation of Alternaria and Cladosporium spore concentrations was performed in two cities in Poland, Szczecin and Cracow, in 2004–2013. The meteorological parameters taken to assess their impact on fungal spores were average, maximum and minimum temperature, relat ...
DOI:: 10.1007/s10453-015-9411-5
PubMed:: 27034536
PubMed Central:: PMC4773472
: https://doi.org/10.1007/s10453-015-9411-5

84. A 2015 outbreak of Getah virus infection occurring among Japanese racehorses sequentially to an outbreak in 2014 at the same site

Author:: Hiroshi Bannai; Akihiro Ochi; Manabu Nemoto; Koji Tsujimura; Takashi Yamanaka; Takashi Kondo
Source:: BMC veterinary research 2016 v.12 no.1 pp. 98
ISSN:: 1746-6148
Subject:: Getah virus; breeding; epizootic diseases; farms; racehorses; risk; risk estimate; seroprevalence; training (animals); vaccination; viruses; Japan
Abstract:: ... BACKGROUND: As we reported previously, Getah virus infection occurred in horses at the Miho training center of the Japan Racing Association in 2014. This was the first outbreak after a 31-year absence in Japan. Here, we report a recurrent outbreak of Getah virus infection in 2015, sequential to the 2014 one at the same site, and we summarize its epizootiological aspects to estimate the risk of fur ...
DOI:: 10.1186/s12917-016-0741-5
PubMed:: 27286658
PubMed Central:: PMC4902926
: https://doi.org/10.1186/s12917-016-0741-5

85. A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interactions

Author:: Eliza L.S. Fong; Xinhai Wan; Jun Yang; Micaela Morgado; Antonios G. Mikos; Daniel A. Harrington; Nora M. Navone; Mary C. Farach-Carson
Source:: Biomaterials 2016 v.77 pp. 164-172
ISSN:: 0142-9612
Subject:: cell viability; coculture; fibroblast growth factors; humans; hydrocolloids; metastasis; models; patients; phenotype; prostatic neoplasms
Abstract:: ... Patient-derived xenograft (PDX) models better represent human cancer than traditional cell lines. However, the complex in vivo environment makes it challenging to employ PDX models to investigate tumor-stromal interactions, such as those that mediate prostate cancer (PCa) bone metastasis. Thus, we engineered a defined three-dimensional (3D) hydrogel system capable of supporting the co-culture of P ...
DOI:: 10.1016/j.biomaterials.2015.10.059
PubMed:: 26599623
PubMed Central:: PMC4684431
: https://doi.org/10.1016/j.biomaterials.2015.10.059

86. A 5-year longitudinal analysis of modifiable predictors for outdoor play and screen-time of 2- to 5-year-olds

Author:: Huilan Xu; Li Ming Wen; Louise L Hardy; Chris Rissel
Source:: international journal of behavioral nutrition and physical activity 2016 v.13 no.1 pp. 96
ISSN:: 1479-5868
Subject:: child development; childhood; childhood obesity; children; clinical trials; demographic statistics; early development; infants; interviews; longitudinal studies; mothers; physical activity; pregnancy; pregnant women; regression analysis; stomach; Australia
Abstract:: ... BACKGROUND: Early childhood is a critical time for establishing physical activity and sedentary behaviours. Identifying modifiable predictors of physical activity and sedentary behaviours in the early life stages can inform the development of early intervention programs. The aim of this study was to identify modifiable predictors of outdoor play (a proxy of physical activity) and screen-time in 2- ...
DOI:: 10.1186/s12966-016-0422-6
PubMed:: 27561357
PubMed Central:: PMC5000406
: https://doi.org/10.1186/s12966-016-0422-6

87. A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes

Author:: Ravichandran Kanchana R.; Taguchi Alexander T.; Wei Yifeng; Tommos Cecilia; Nocera Daniel G.; Stubbe JoAnne
Source:: Journal of the American Chemical Society 2016 v.138 no.41 pp. 13706-13716
ISSN:: 1520-5126
Subject:: Escherichia coli; adenosine triphosphate; models; pH; ribonucleotide reductase; ribonucleotides; solvents; temperature; thermodynamics; tyrosine
Abstract:: ... Escherichia coli class Ia ribonucleotide reductase (RNR) converts ribonucleotides to deoxynucleotides. A diferric-tyrosyl radical (Y₁₂₂•) in one subunit (β2) generates a transient thiyl radical in another subunit (α2) via long-range radical transport (RT) through aromatic amino acid residues (Y₁₂₂ ⇆ [W₄₈] ⇆ Y₃₅₆ in β2 to Y₇₃₁ ⇆ Y₇₃₀ ⇆ C₄₃₉ in α2). Equilibration of Y₃₅₆•, Y₇₃₁•, and Y₇₃₀• was recen ...
DOI:: 10.1021/jacs.6b08200
PubMed:: 28068088
PubMed Central:: PMC5224885
: https://doi.org/10.1021/jacs.6b08200

88. A Bayesian credible subgroups approach to identifying patient subgroups with positive treatment effects

Author:: Patrick M. Schnell; Qi Tang; Walter W. Offen; Bradley P. Carlin
Source:: Biometrics 2016 v.72 no.4 pp. 1026-1036
ISSN:: 0006-341X
Subject:: Alzheimer disease; biometry; clinical trials; patients; risk; therapeutics
Abstract:: ... Many new experimental treatments benefit only a subset of the population. Identifying the baseline covariate profiles of patients who benefit from such a treatment, rather than determining whether or not the treatment has a population‐level effect, can substantially lessen the risk in undertaking a clinical trial and expose fewer patients to treatments that do not benefit them. The standard analys ...
DOI:: 10.1111/biom.12522
PubMed:: 27159131
PubMed Central:: PMC5102829
: https://doi.org/10.1111/biom.12522

89. A Bayesian hierarchical framework for modeling brain connectivity for neuroimaging data

Author:: Shuo Chen; F. DuBois Bowman; Helen S. Mayberg
Source:: Biometrics 2016 v.72 no.2 pp. 596-605
ISSN:: 0006-341X
Subject:: Markov chain; biometry; brain; image analysis; magnetic resonance imaging; models
Abstract:: ... We propose a novel Bayesian hierarchical model for brain imaging data that unifies voxel‐level (the most localized unit of measure) and region‐level brain connectivity analyses, and yields population‐level inferences. Functional connectivity generally refers to associations in brain activity between distinct locations. The first level of our model summarizes brain connectivity for cross‐region vox ...
DOI:: 10.1111/biom.12433
PubMed:: 26501687
PubMed Central:: PMC4846590
: https://doi.org/10.1111/biom.12433

90. A Bayesian joint model of menstrual cycle length and fecundity

Author:: Kirsten J. Lum; Rajeshwari Sundaram; Germaine M. Buck Louis; Thomas A. Louis
Source:: Biometrics 2016 v.72 no.1 pp. 193-203
ISSN:: 0006-341X
Subject:: biometry; cotinine; fecundity; females; males; menstrual cycle; models; ovulation; pregnancy; probability; semen
Abstract:: ... Menstrual cycle length (MCL) has been shown to play an important role in couple fecundity, which is the biologic capacity for reproduction irrespective of pregnancy intentions. However, a comprehensive assessment of its role requires a fecundity model that accounts for male and female attributes and the couple's intercourse pattern relative to the ovulation day. To this end, we employ a Bayesian j ...
DOI:: 10.1111/biom.12379
PubMed:: 26295923
PubMed Central:: PMC4761533
: https://doi.org/10.1111/biom.12379

91. A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds

Author:: P.M. Down; A.J. Bradley; J.E. Breen; W.J. Browne; T. Kypraios; M.J. Green
Source:: Preventive veterinary medicine 2016 v.133 pp. 64-72
ISSN:: 0167-5877
Subject:: Bayesian theory; Markov chain; calving; cost effectiveness; dairy cows; dairy farming; dairy herds; decision making; decision support systems; farmers; mastitis; models; prediction; risk reduction; somatic cell count; therapeutics; uncertainty; United Kingdom
Abstract:: ... Importance of the dry period with respect to mastitis control is now well established although the precise interventions that reduce the risk of acquiring intramammary infections during this time are not clearly understood. There are very few intervention studies that have measured the clinical efficacy of specific mastitis interventions within a cost-effectiveness framework so there remains a lar ...
DOI:: 10.1016/j.prevetmed.2016.09.012
PubMed:: 27720028
PubMed Central:: PMC5073076
: https://doi.org/10.1016/j.prevetmed.2016.09.012

92. A Bayesian mixture model for missing data in marine mammal growth analysis

Author:: Mary E. Shotwell; Wayne E. McFee; Elizabeth H. Slate
Source:: Environmental and ecological statistics 2016 v.23 no.4 pp. 585-603
ISSN:: 1352-8505
Subject:: Tursiops truncatus; body length; dolphins; models; necropsy; nose; physiology; weather; South Carolina
Abstract:: ... Much of what is known about bottle nose dolphin (Tursiops truncatus) anatomy and physiology is based on necropsies from stranding events. Measurements of total body length, total body mass, and age are used to estimate growth. It is more feasible to retrieve and transport smaller animals for total body mass measurement than larger animals, introducing a systematic bias in sampling. Adverse weather ...
DOI:: 10.1007/s10651-016-0355-x
PubMed:: 28503080
PubMed Central:: PMC5425172
: https://doi.org/10.1007/s10651-016-0355-x

93. A Bayesian model for quantifying the change in mortality associated with future ozone exposures under climate change

Author:: Stacey E. Alexeeff; Gabriele G. Pfister; Doug Nychka
Source:: Biometrics 2016 v.72 no.1 pp. 281-288
ISSN:: 0006-341X
Subject:: Bayesian theory; biometry; climate change; decision making; environmental impact; models; mortality; ozone; public health; summer; uncertainty; weather; United States
Abstract:: ... Climate change is expected to have many impacts on the environment, including changes in ozone concentrations at the surface level. A key public health concern is the potential increase in ozone‐related summertime mortality if surface ozone concentrations rise in response to climate change. Although ozone formation depends partly on summertime weather, which exhibits considerable inter‐annual vari ...
DOI:: 10.1111/biom.12383
PubMed:: 26302149
PubMed Central:: PMC5656058
: https://doi.org/10.1111/biom.12383

94. A Bioadhesive Nanoparticle–Hydrogel Hybrid System for Localized Antimicrobial Drug Delivery

Author:: Zhang Yue; Zhang Jianhua; Chen Maggie; Gong Hua; Thamphiwatana Soracha; Eckmann Lars; Gao Weiwei; Zhang Liangfang
Source:: ACS Applied Materials & Interfaces 2016 v.8 no.28 pp. 18367-18374
ISSN:: 1944-8252
Subject:: Escherichia coli; adhesion; antibiotics; bacterial colonization; drugs; hydrogels; mice; mussels; nanoparticles; shear stress; toxicity
Abstract:: ... Effective antibacterial treatment at the infection site associated with high shear forces remains challenging, owing largely to the lack of durably adhesive and safe delivery platforms that can enable localized antibiotic accumulation against bacterial colonization. Inspired by delivery systems mimicking marine mussels for adhesion, herein, we developed a bioadhesive nanoparticle–hydrogel hybrid ( ...
DOI:: 10.1021/acsami.6b04858
PubMed:: 27352845
PubMed Central:: PMC4983189
: https://doi.org/10.1021/acsami.6b04858

95. A Biobank for Long-term and Sustainable Research in the Field of Congenital Heart Disease in Germany

Author:: Thomas Pickardt; Eva Niggemeyer; Ulrike M.M. Bauer; Hashim Abdul-Khaliq
Source:: Genomics, proteomics & bioinformatics 2016 v.14 no.4 pp. 181-190
ISSN:: 1672-0229
Subject:: DNA; abnormal development; adulthood; congenital abnormalities; early diagnosis; heart; heart diseases; parents; patients; phenotype; surgery; tissues; Germany
Abstract:: ... Congenital heart disease (CHD) is the most frequent birth defect (0.8%–1% of all live births). Due to the advance in prenatal and postnatal early diagnosis and treatment, more than 90% of these patients survive into adulthood today. However, several mid- and long-term morbidities are dominating the follow-up of these patients. Due to the rarity and heterogeneity of the phenotypes of CHD, multicent ...
DOI:: 10.1016/j.gpb.2016.03.003
PubMed:: 27132144
PubMed Central:: PMC4996858
: https://doi.org/10.1016/j.gpb.2016.03.003

96. A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

Author:: Alejandra Bruna; Oscar M. Rueda; Wendy Greenwood; Ankita Sati Batra; Maurizio Callari; Rajbir Nath Batra; Katherine Pogrebniak; Jose Sandoval; John W. Cassidy; Ana Tufegdzic-Vidakovic; Stephen-John Sammut; Linda Jones; Elena Provenzano; Richard Baird; Peter Eirew; James Hadfield; Matthew Eldridge; Anne McLaren-Douglas; Andrew Barthorpe; Howard Lightfoot; Mark J. O’Connor; Joe Gray; Javier Cortes; Jose Baselga; Elisabetta Marangoni; Alana L. Welm; Samuel Aparicio; Violeta Serra; Mathew J. Garnett; Carlos Caldas
Source:: Cell 2016 v.167 pp. 260-274.e22
ISSN:: 0092-8674
Subject:: biomarkers; breast neoplasms; drugs; explants; mice; models; neoplasm cells
Abstract:: ... The inter- and intra-tumor heterogeneity of breast cancer needs to be adequately captured in pre-clinical models. We have created a large collection of breast cancer patient-derived tumor xenografts (PDTXs), in which the morphological and molecular characteristics of the originating tumor are preserved through passaging in the mouse. An integrated platform combining in vivo maintenance of these PD ...
DOI:: 10.1016/j.cell.2016.08.041
PubMed:: 27641504
PubMed Central:: PMC5037319
: https://doi.org/10.1016/j.cell.2016.08.041

97. A Bipartite Network-based Method for Prediction of Long Non-coding RNA–protein Interactions

Author:: Mengqu Ge; Ao Li; Minghui Wang
Source:: Genomics, proteomics & bioinformatics 2016 v.14 no.1 pp. 62-71
ISSN:: 1672-0229
Subject:: RNA-binding proteins; case studies; humans; mutation; non-coding RNA; prediction
Abstract:: ... As one large class of non-coding RNAs (ncRNAs), long ncRNAs (lncRNAs) have gained considerable attention in recent years. Mutations and dysfunction of lncRNAs have been implicated in human disorders. Many lncRNAs exert their effects through interactions with the corresponding RNA-binding proteins. Several computational approaches have been developed, but only few are able to perform the prediction ...
DOI:: 10.1016/j.gpb.2016.01.004
PubMed:: 26917505
PubMed Central:: PMC4792848
: https://doi.org/10.1016/j.gpb.2016.01.004

98. A Brief History of Research on Mitotic Mechanisms

Author:: J. Richard McIntosh; Thomas Hays
Source:: Biology 2016 v.5 no.4 pp. -
ISSN:: 2079-7737
Subject:: biochemistry; chromosome segregation; chromosomes; electron microscopy; fluorescence; fruits; light microscopy; mitosis; molecular biology; technology
Abstract:: ... This chapter describes in summary form some of the most important research on chromosome segregation, from the discovery and naming of mitosis in the nineteenth century until around 1990. It gives both historical and scientific background for the nine chapters that follow, each of which provides an up-to-date review of a specific aspect of mitotic mechanism. Here, we trace the fruits of each new t ...
DOI:: 10.3390/biology5040055
PubMed:: 28009830
PubMed Central:: PMC5192435
: https://doi.org/10.3390/biology5040055

99. A C-banded karyotype of mitotic chromosomes in diploid purple coneflower (Echinacea purpurea L.)

Author:: Weizhen Jiang; Qingling Li; Xiaolu Chen; Yi Ren; Rong Chen; Hong Wu; Yuesheng Yang
Source:: Hereditas 2016 v.153 no.1 pp. 14
ISSN:: 1601-5223
Subject:: Echinacea purpurea; aneuploidy; breeding programs; chromosome banding; complement; diploidy; karyotyping; mitosis; telomeres
Abstract:: ... BACKGROUND: Aneuploid ermpglasm is an important resource for genetic studies and identification of individual chromosomes in the cells of the aneuploid is an important step. The karyotype has already been established for purple coneflower (Echinacea purpurea L.), but due to the high similarity in the morphology of several pairs of chromosomes in this species, it cannot be used to identify individu ...
DOI:: 10.1186/s41065-016-0016-y
PubMed:: 28096776
PubMed Central:: PMC5226108
: https://doi.org/10.1186/s41065-016-0016-y

100. A CRISPR/Cas9 mediated point mutation in the alpha 6 subunit of the nicotinic acetylcholine receptor confers resistance to spinosad in Drosophila melanogaster

Author:: Christoph T. Zimmer; William T. Garrood; A. Mirel Puinean; Manuela Eckel-Zimmer; Martin S. Williamson; T.G. Emyr Davies; Chris Bass
Source:: Insect biochemistry and molecular biology 2016 v.73 pp. 62-69
ISSN:: 0965-1748
Subject:: insects; loss-of-function mutation; amino acid substitution; genetic background; insecticide resistance; Frankliniella occidentalis; cholinergic receptors; bioassays; reverse transcriptase polymerase chain reaction; spinosad; mutants; nervous system; site-directed mutagenesis; inheritance (genetics); exons; Drosophila melanogaster; point mutation
Abstract:: ... Spinosad, a widely used and economically important insecticide, targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. Several studies have associated loss of function mutations in the insect nAChR α6 subunit with resistance to spinosad, and in the process identified this particular subunit as the specific target site. More recently a single non-synonymous point mutati ...
DOI:: 10.1016/j.ibmb.2016.04.007
PubMed:: 27117524
PubMed Central:: PMC4876769
: https://doi.org/10.1016/j.ibmb.2016.04.007

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1. (+) RNA virus replication compartments: a safe home for (most) viral replication

2. (-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice

3. (BB)-Carboryne Complex of Ruthenium: Synthesis by Double B–H Activation at a Single Metal Center

4. (Bio)transformation of 2,4-dinitroanisole (DNAN) in soils

5. (Z)-9-Tricosene based Musca domestica lure study on a garbage dump yard using plywood sticky trap baited with fish meal

6. (±)-Evodiakine, A Pair of Rearranged Rutaecarpine-Type Alkaloids From Evodia rutaecarpa

7. (−)-Rhazinilam and the diphenylpyridazinone NSC 613241: Two compounds inducing the formation of morphologically similar tubulin spirals but binding apparently to two distinct sites on tubulin

8. 0.9% saline is neither normal nor physiological

9. 1,25-Dihydroxy vitamin D3 stimulates system A amino acid transport in primary human trophoblast cells

10. 1,25-Dihydroxyvitamin D induces the glutamate transporter SLC1A1 and alters glutamate handling in non-transformed mammary cells

11. 1,25-Dihydroxyvitamin D3 modulates calcium transport in goat mammary epithelial cells in a dose- and energy-dependent manner

12. 1,3,5-Benzenetribenzoic Acid on Cu(111) and Graphene/Cu(111): A Comparative STM Study

13. 1,3-Dipolar Cycloaddition with Diazo Groups: Noncovalent Interactions Overwhelm Strain

14. 1,3-Dipolar Cycloadditions of Diazo Compounds in the Presence of Azides

15. 1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus

16. 1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure

17. 100Hz neutron radiography at the BOA beamline using a parabolic focussing guide

18. 11-Step Total Synthesis of (−)-Maoecrystal V

19. 11-Step Total Synthesis of Araiosamines

20. 11-Step Total Synthesis of Pallambins C and D

21. 13C kinetic isotope effects on the reaction of a flavin amine oxidase determined from whole molecule isotope effects

22. 13C metabolic flux analysis of microbial and mammalian systems is enhanced with GC-MS measurements of glycogen and RNA labeling

23. 14-day toxicity studies of tetravalent and pentavalent vanadium compounds in Harlan Sprague Dawley rats and B6C3F1/N mice via drinking water exposure

24. 15‐F2t‐Isoprostane Concentrations and Oxidant Status in Lactating Dairy Cattle with Acute Coliform Mastitis

25. 16S rRNA amplicon sequencing dataset for conventionalized and conventionally raised zebrafish larvae

26. 17O NMR Investigation of Water Structure and Dynamics

27. 17β-Estradiol alters oxidative damage and oxidative stress response protein expression in the mouse mammary gland

28. 18S rDNA dataset profiling microeukaryotic populations within Chicago area nearshore waters

29. 193 nm Ultraviolet Photodissociation Mass Spectrometry for Phosphopeptide Characterization in the Positive and Negative Ion Modes

30. 193 nm Ultraviolet Photodissociation Mass Spectrometry of Tetrameric Protein Complexes Provides Insight into Quaternary and Secondary Protein Topology

31. 1H NMR and FT-IR dataset based structural investigation of poly(amic acid)s and polyimides from 4,4′-diaminostilbene

32. 1H-NMR dataset for hydroxycoumarins –Aesculetin, 4-Methylumbelliferone, and umbelliferone

33. 1H‐NMR screening for the high‐throughput determination of genotype and environmental effects on the content of asparagine in wheat grain

34. 1α,25-Dihydroxyvitamin D Inhibits the Metastatic Capability of MCF10CA1a and MDA-MB-231 Cells in an In Vitro Model of Breast to Bone Metastasis

35. 2-Aryl-5-carboxytetrazole as a New Photoaffinity Label for Drug Target Identification

36. 2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists

37. 2-Cys peroxiredoxin is required in successful blood-feeding, reproduction, and antioxidant response in the hard tick Haemaphysalis longicornis

38. 2-D DIGE proteomic profiles of three strains of Fusarium graminearum grown in agmatine or glutamic acid medium

39. 2-amino-1-methyl-6-phenylimidazo(4,5-b) pyridine (PhIP) induces gene expression changes in JAK/STAT and MAPK pathways related to inflammation, diabetes and cancer

40. 2-cyclohexylamino-5,8-dimethoxy-1,4-naphthoquinone inhibits LPS-induced BV2 microglial activation through MAPK/NF-kB signaling pathways

41. 2015 ACVIM Small Animal Consensus Statement on Seizure Management in Dogs

42. 2015 Distinguished career award

43. 25 years on and no end in sight: a perspective on the role of RecG protein

44. 2D-PAGE analysis of the soluble proteins of the tropical liver fluke, Fasciola gigantica and biliary amphistome, Gigantocotyle explanatum, concurrently infecting Bubalus bubalis

45. 3-Butenyl isothiocyanate: a hydrolytic product of glucosinolate as a potential cytotoxic agent against human cancer cell lines

46. 3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma

47. 3-D individual cell based computational modeling of tumor cell–macrophage paracrine signaling mediated by EGF and CSF-1 gradients

48. 3D FSE Cube and VIPR-aTR 3.0 Tesla magnetic resonance imaging predicts canine cranial cruciate ligament structural properties

49. 3D RNA and Functional Interactions from Evolutionary Couplings

50. 3D Raman imaging of systemic endothelial dysfunction in the murine model of metastatic breast cancer

51. 3D bioprinting for engineering complex tissues

52. 3D brown adipogenesis to create “Brown-Fat-in-Microstrands”

53. 3D nanostructured inkjet printed graphene via UV-pulsed laser irradiation enables paper-based electronics and electrochemical devices

54. 3D porous chitosan–alginate scaffolds promote proliferation and enrichment of cancer stem-like cells

55. 3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin

56. 3D-printed microfluidic devices: fabrication, advantages and limitations—a mini review

57. 3D-printed supercapacitor-powered electrochemiluminescent protein immunoarray

58. 3DRobot: automated generation of diverse and well-packed protein structure decoys

59. 3DSEM: A 3D microscopy dataset

60. 4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?

61. 5,7-Dimethoxycoumarin prevents chronic mild stress induced depression in rats through increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels

62. 5-Hydroxymethylcytosine in E-box motifs ACATGTG and ACACGTG increases DNA-binding of the B-HLH transcription factor TCF4

63. 53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms

64. 6-shogaol attenuates H2O2-induced oxidative stress via upregulation of Nrf2-mediated γ-glutamylcysteine synthetase and heme oxygenase expression in HepG2 cells

65. 7SKiing on chromatin: Move globally, act locally

66. 9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages

67. 9-Fluorenylmethyl (Fm) Disulfides: Biomimetic Precursors for Persulfides

68. Lactobacillus fermentum CRL1446 Ameliorates Oxidative and Metabolic Parameters by Increasing Intestinal Feruloyl Esterase Activity and Modulating Microbiota in Caloric-Restricted Mice

69. Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice