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- Healy, Kevin E., et al. Show all 10 Authors
- Biomaterials 2016 v.93 pp. 95-105
- angiogenesis; binding capacity; cell viability; crosslinking; diabetic retinopathy; drugs; enzyme-linked immunosorbent assay; eyes; gel chromatography; half life; hyaluronic acid; hydrogels; light scattering; models; molecular weight; patients; polyacrylamide gel electrophoresis; protein degradation; therapeutics; vascular endothelial growth factors
- ... Anti-VEGF drugs that are used in conjunction with laser ablation to treat patients with diabetic retinopathy suffer from short half-lives in the vitreous of the eye resulting in the need for frequent intravitreal injections. To improve the intravitreal half-life of anti-VEGF drugs, such as the VEGF decoy receptor sFlt-1, we developed multivalent bioconjugates of sFlt-1 grafted to linear hyaluronic ...
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