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- Jung, Hosung, et al. Show all 8 Authors
- Cell 2016 v.166 pp. 181-192
- adults; alternative splicing; axons; ganglia; genes; high-throughput nucleotide sequencing; messenger RNA; mice; neural networks; neurodegenerative diseases; synaptogenesis; translation (genetics)
- ... Local mRNA translation mediates the adaptive responses of axons to extrinsic signals, but direct evidence that it occurs in mammalian CNS axons in vivo is scant. We developed an axon-TRAP-RiboTag approach in mouse that allows deep-sequencing analysis of ribosome-bound mRNAs in the retinal ganglion cell axons of the developing and adult retinotectal projection in vivo. The embryonic-to-postnatal ax ...
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