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- Kristin Moreth, et al. Show all 42 Authors
- Cell 2016 v.167 pp. 843-857.e14
- adipocytes; adverse effects; atherosclerosis; cardiovascular system; chemical engineering; cholesterol metabolism; glucagon; glucose; hepatocytes; hybridization; hyperlipidemia; mice; noninsulin-dependent diabetes mellitus; obesity; synergism; thyroid hormones; white adipose tissue
- ... Glucagon and thyroid hormone (T3) exhibit therapeutic potential for metabolic disease but also exhibit undesired effects. We achieved synergistic effects of these two hormones and mitigation of their adverse effects by engineering chemical conjugates enabling delivery of both activities within one precisely targeted molecule. Coordinated glucagon and T3 actions synergize to correct hyperlipidemia, ...