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- Mei, Leixia, et al. Show all 9 Authors
- Journal of materials chemistry B 2016 v.4 no.36 pp. 6043-6051
- P-glycoproteins; carbon; drug delivery systems; drug therapy; etoposide; irradiation; ligands; monoclonal antibodies; multiple drug resistance; near infrared radiation; neoplasms; oxidation; photothermotherapy; polyethylene glycol; synergism
- ... Multidrug resistance (MDR) is a major obstacle to cancer chemotherapy due to the overexpression of P-glycoprotein (P-gp). Herein, etoposide (ETO) was loaded onto oxidized carbon nanohorns (oxCNHs), which were modified by polyethylene glycol (PEG) and further functionalized with the targeting ligand P-gp monoclonal antibody (PA) in an attempt to overcome MDR. The obtained drug delivery system (ETO@ ...