Author: "Jung, Hosung" / Publication Year: 2016 - PubAg Search Results

Main content area

Did you mean to type: hojung or hyosung?

1 Search Results

1. Dynamic Axonal Translation in Developing and Mature Visual Circuits

Author:: Jung, Hosung, et al. ; Shigeoka, Toshiaki; Jung, Jane; Turner-Bridger, Benita; Ohk, Jiyeon; Lin, Julie Qiaojin; Amieux, Paul S.; Holt, Christine E.; Show all 8 Authors
Source:: Cell 2016 v.166 pp. 181-192
ISSN:: 0092-8674
Subject:: adults; alternative splicing; axons; ganglia; genes; high-throughput nucleotide sequencing; messenger RNA; mice; neural networks; neurodegenerative diseases; synaptogenesis; translation (genetics)
Abstract:: ... Local mRNA translation mediates the adaptive responses of axons to extrinsic signals, but direct evidence that it occurs in mammalian CNS axons in vivo is scant. We developed an axon-TRAP-RiboTag approach in mouse that allows deep-sequencing analysis of ribosome-bound mRNAs in the retinal ganglion cell axons of the developing and adult retinotectal projection in vivo. The embryonic-to-postnatal ax ...
DOI:: 10.1016/j.cell.2016.05.029
PubMed:: 27321671
PubMed Central:: PMC4930487
: http://dx.doi.org/10.1016/j.cell.2016.05.029