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1. HBV Slow Maturation Process Leads to Infection

Author:
Watashi, Koichi
Source:
Trends in microbiology 2016 v.24 no.8 pp. 597-599
ISSN:
0966-842X
Subject:
Hepatitis B virus,   etc   ; heparan sulfate; proteoglycans; tissues;     Show all 4 Subjects
Abstract:
... Initial hepatitis B virus (HBV) attachment occurs via heparan sulfate proteoglycans (HSPGs), which then trigger receptor-mediated internalization. Although HSPGs express in many tissues, HBV is destined for hepatotropic infection. A recent paper by Seitz et al. proposed that the slow viral maturation process plays a critical role in liver-specific distribution. ...
DOI:
10.1016/j.tim.2016.06.007

2. The unique role of the hepatitis virus B X protein on HEK 293 cell morphology and cellular change

Author:
Zhang, Yongjie; Cheng, Jiali; Liu, Chaohong
Source:
Archives of virology 2016 v.161 no.5 pp. 1347-1352
ISSN:
0304-8608
Subject:
Hepatitis B virus,   etc   ; apoptosis; cadherins; cell growth; hepatoma;     Show all 5 Subjects
Abstract:
... The function of the hepatitis B virus X protein (HBx) has been investigated in hepatoma cell lines before; however, its function in the canonical HEK 293 cell line has not been addressed. In this study, we found that HBx increased cellular interaction by fusing the gap between HEK 293 cells, which is different from what has been reported previously. We also found that HBx enhanced the expression o ...
DOI:
10.1007/s00705-016-2786-y

3. Nuclear factor Y regulates ancient budgerigar hepadnavirus core promoter activity

Author:
Shen, Zhongliang; Liu, Yanfeng; Luo, Mengjun; Wang, Wei; Liu, Jing; Liu, Wei; Pan, Shaokun; Xie, Youhua
Source:
Biochemical and biophysical research communications 2016 v.478 no.2 pp. 825-830
ISSN:
0006-291X
Subject:
Duck hepatitis B virus; Hepatitis B virus,   etc   ; binding sites; bioinformatics; budgerigars; cell lines; chickens; fossils; gene expression; genome; humans; transcription (genetics); transcription factors; viruses;     Show all 14 Subjects
Abstract:
... Endogenous viral elements (EVE) in animal genomes are the fossil records of ancient viruses and provide invaluable information on the origin and evolution of extant viruses. Extant hepadnaviruses include avihepadnaviruses of birds and orthohepadnaviruses of mammals. The core promoter (Cp) of hepadnaviruses is vital for viral gene expression and replication. We previously identified in the budgerig ...
DOI:
10.1016/j.bbrc.2016.08.032

4. HBsAg and HBeAg in the prediction of a clinical response to peginterferon α-2b therapy in Chinese HBeAg-positive patients

Author:
Yang, Song; Xing, Huichun; Wang, Yuming; Hou, Jinlin; Luo, Duande; Xie, Qing; Ning, Qin; Ren, Hong; Ding, Huiguo; Sheng, Jifang; Wei, Lai; Chen, Shijun; Fan, Xiaoling; Huang, Wenxiang; Pan, Chen; Gao, Zhiliang; Zhang, Jiming; Zhou, Boping; Chen, Guofeng; Wan, Mobin; Tang, Hong; Wang, Guiqiang; Yang, Yuxiu; Xu, Dongping; Dong, Peiling; Wang, Qixin; Wang, Jue; Bognar, Fernando A.; Xu, Daozhen; Cheng, Jun
Source:
Virology journal 2016 v.13 no.1 pp. 180
ISSN:
1743-422X
Subject:
Hepatitis B virus,   etc   ; DNA; chronic hepatitis B; hepatitis B antigens; interferons; patients; prediction; seroconversion; therapeutics;     Show all 9 Subjects
Abstract:
... BACKGROUND: This study aimed to evaluate the predictive values of hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) levels in 171 Chinese patients with chronic hepatitis B who received a 48-week course of pegylated interferon alfa-2b therapy at 1.5 mcg/kg. METHODS: HBsAg, HBeAg, and hepatitis B virus (HBV) DNA levels were measured at baseline and weeks 12, 24, 48, and 72. Clini ...
DOI:
10.1186/s12985-016-0640-1
PubMed:
27793166
PubMed Central:
PMC5084370

5. Occult hepatitis B virus infection: influence of S protein variants

Author:
Zhang, Zhenhua; Zhang, Ling; Dai, Yu; Zhang, Yafei; Li, Jun; Li, Xu
Source:
Virology journal 2016 v.13 no.1 pp. 10
ISSN:
1743-422X
Subject:
Hepatitis B virus,   etc   ; stop codon; DNA; mutation; hydrophilicity; clones; hepatitis B; hepatitis B antigens; patients; pathogenesis;     Show all 10 Subjects
Abstract:
... BACKGROUND: In occult hepatitis B viral infection (OBI), the persistence of hepatitis B virus (HBV) DNA is associated with a lack of hepatitis B surface antigen (HBsAg). To assess the possible role of HBsAg immune escape variants in OBI patients, variability in the HBV S gene was evaluated for OBI patients as well as chronic HBV infection patients from the same families. METHODS: We selected 17 HB ...
DOI:
10.1186/s12985-016-0464-z
PubMed:
26786229
PubMed Central:
PMC4717550

6. Improving hepatitis B birth dose in rural Lao People’s Democratic Republic through the use of mobile phones to facilitate communication

Author:
Xeuatvongsa, Anonh; Datta, Siddhartha Sankar; Moturi, Edna; Wannemuehler, Kathleen; Philakong, Phanmanisone; Vongxay, Viengnakhone; Vilayvone, Vansy; Patel, Minal K.
Source:
Vaccine 2016 v.34 no.47 pp. 5777-5784
ISSN:
0264-410X
Subject:
Hepatitis B virus,   etc   ; children; health care workers; hepatitis B; outreach; surveys; vaccines; villages; virus transmission; volunteers;     Show all 10 Subjects
Abstract:
... Hepatitis B vaccine birth dose (HepB-BD) was introduced in Lao People’s Democratic Republic to prevent perinatal hepatitis B virus transmission in 2008; high coverage is challenging since only 38% of births occur in a health facility. Healthcare workers report being unaware of home births and thus unable to conduct timely postnatal care (PNC) home visits. A quasi-experimental pilot study was condu ...
DOI:
10.1016/j.vaccine.2016.09.056

7. Hepatitis B virus resistance substitutions: long-term analysis by next-generation sequencing

Author:
Jones, Leandro R.; Sede, Mariano; Manrique, Julieta M.; Quarleri, Jorge
Source:
Archives of virology 2016 v.161 no.10 pp. 2885-2891
ISSN:
0304-8608
Subject:
Hepatitis B virus,   etc   ; high-throughput nucleotide sequencing; mutation; patients; phylogeny; therapeutics; viruses;     Show all 7 Subjects
Abstract:
... HBV phylogenetics and resistance-associated mutations (RAMs) were surveyed by next-generation sequencing of 21 longitudinal samples from seven patients entering antiviral therapy. The virus populations were dominated by a few abundant lineages that coexisted with substantial numbers of low-frequency variants. A few low-frequency RAMs were observed before treatment, but new ones emerged, and their ...
DOI:
10.1007/s00705-016-2959-8

8. Molecular epidemiology of hepatitis B virus in Misiones, Argentina

Author:
Mojsiejczuk, Laura Noelia; Torres, Carolina; Sevic, Ina; Badano, Inés; Malan, Richard; Flichman, Diego Martin; Liotta, Domingo Javier; Campos, Rodolfo Hector
Source:
Infection, genetics, and evolution 2016 v.44 pp. 34-42
ISSN:
1567-1348
Subject:
Hepatitis B virus,   etc   ; ancestry; blood; genetic distance; genotype; molecular epidemiology; monophyly; nucleotide sequences; public health; Argentina;     Show all 10 Subjects
Abstract:
... Hepatitis B virus (HBV) infection is a major public health problem worldwide. The aims of this study were to describe the molecular epidemiology of HBV in the Province of Misiones, Argentina and estimate the phylodynamic of the main groups in a Bayesian coalescent framework. To this end, partial or complete genome sequences were obtained from 52 blood donor candidates.The phylogenetic analysis bas ...
DOI:
10.1016/j.meegid.2016.06.032

9. Roles of long noncoding RNAs in hepatocellular carcinoma

Author:
Shi, Linxi; Peng, Fang; Tao, Yongguang; Fan, Xuegong; Li, Ning
Source:
Virus research 2016 v.223 pp. 131-139
ISSN:
0168-1702
Subject:
Hepatitis B virus,   etc   ; Hepatitis C virus; carcinogenesis; hepatoma; human diseases; mortality; non-coding RNA; risk factors;     Show all 8 Subjects
Abstract:
... Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with high prevalence and lethality. Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infection are the major risk factors for HCC. Long noncoding RNAs (lncRNAs) are involved in diverse biological processes, and aberrant lncRNA expression is relevant to many human diseases including HCC. Although many researches on HCC ha ...
DOI:
10.1016/j.virusres.2016.06.008

10. A “signal on” protection-displacement-hybridization-based electrochemical hepatitis B virus gene sequence sensor with high sensitivity and peculiar adjustable specificity

Author:
Li, Fengqin; Xu, Yanmei; Yu, Xiang; Yu, Zhigang; He, Xunjun; Ji, Hongrui; Dong, Jinghao; Song, Yongbin; Yan, Hong; Zhang, Guiling
Source:
Biosensors & bioelectronics 2016 v.82 pp. 212-216
ISSN:
0956-5663
Subject:
Hepatitis B virus,   etc   ; biosensors; detection limit; electrochemistry; electrodes; gold; nucleotide sequences; point mutation;     Show all 8 Subjects
Abstract:
... One “signal on” electrochemical sensing strategy was constructed for the detection of a specific hepatitis B virus (HBV) gene sequence based on the protection-displacement-hybridization-based (PDHB) signaling mechanism. This sensing system is composed of three probes, one capturing probe (CP) and one assistant probe (AP) which are co-immobilized on the Au electrode surface, and one 3-methylene blu ...
DOI:
10.1016/j.bios.2016.04.014

11. A New Selaginellin from Selaginella moellendorffii Inhibits Hepatitis B Virus Gene Expression and Replication

Author:
Zhu, Bin; Wang, Tian-Bao; Hou, Li-Juan; Lv, Hai-Xia; Liu, A-Min; Zeng, Ping; Li, Ai-Hui
Source:
Chemistry of natural compounds 2016 v.52 no.4 pp. 624-627
ISSN:
0009-3130
Subject:
Hepatitis B virus,   etc   ; Selaginella; chemistry; gene expression; hepatitis B antigens; inhibitory concentration 50; messenger RNA; spectroscopy;     Show all 8 Subjects
Abstract:
... A new compound, selaginellin S (1), was isolated from the whole plants of Selaginella moellendorffii Hieron. Its structure was elucidated on the basis of spectroscopic analysis and ECD calculations. Selaginellin S markedly suppressed the production of HbsAg and HBeAg with IC₅₀ values of 0.026 and 0.032 μg/mL. The transcript of viral mRNA was significantly suppressed by selaginellin S in HepG2.2.15 ...
DOI:
10.1007/s10600-016-1725-1

12. Development and validation of an oligonucleotide ligation assay to detect lamivudine resistance in hepatitis B virus

Author:
Beck, Ingrid A.; Payant, Rachel; Ngo-Giang-Huong, Nicole; Khamduang, Woottichai; Laomanit, Laddawan; Jourdain, Gonzague; Frenkel, Lisa M.
Source:
Journal of virological methods 2016 v.233 pp. 51-55
ISSN:
0166-0934
Subject:
Hepatitis B virus,   etc   ; chronic hepatitis B; drug resistance; lamivudine; monitoring; mutants; mutation; oligonucleotides;     Show all 8 Subjects
Abstract:
... Treatment of chronic hepatitis B virus (HBV) infection with lamivudine-monotherapy rapidly selects mutant variants in a high proportion of individuals. Monitoring lamivudine resistance by consensus sequencing is costly and insensitive for detection of minority variants. An oligonucleotide ligation assay (OLA) for HBV lamivudine-resistance was developed and compared to consensus sequencing. Both as ...
DOI:
10.1016/j.jviromet.2016.03.014

13. Two-way molecular ligation for efficient conversion of monomeric hepatitis B virus DNA constructs into tandem dimers

Author:
Zong, Li; Qin, Yanli; Jia, Haodi; Zhou, Huailiang; Chen, Chaoyang; Qiao, Ke; Zhang, Jiming; Wang, Yongxiang; Li, Jisu; Tong, Shuping
Source:
Journal of virological methods 2016 v.233 pp. 46-50
ISSN:
0166-0934
Subject:
Hepatitis B virus,   etc   ; DNA; RNA; chemical bonding; dephosphorylation; genome; restriction endonucleases; transcription (genetics);     Show all 8 Subjects
Abstract:
... Replication of the 3.2-kb hepatitis B virus (HBV) genome is driven by the covalently closed circular (ccc) DNA in the nucleus, from which four classes of co-terminal RNAs are transcribed. Genome replication requires just the 3.5-kb pregenomic RNA, which is terminally redundant. Cloning the full-length HBV genome into a vector disrupts its continuity, thus preventing genome replication at the step ...
DOI:
10.1016/j.jviromet.2016.03.012

14. Polydimethylsiloxane-Paper Hybrid Lateral Flow Assay for Highly Sensitive Point-of-Care Nucleic Acid Testing

Author:
Choi, Jane Ru; Liu, Zhi; Hu, Jie; Tang, Ruihua; Gong, Yan; Feng, Shangsheng; Ren, Hui; Wen, Ting; Yang, Hui; Qu, Zhiguo; Pingguan-Murphy, Belinda; Xu, Feng
Source:
Analytical chemistry 2016 v.88 no.12 pp. 6254-6264
ISSN:
1520-6882
Subject:
Hepatitis B virus,   etc   ; blood sampling; colorimetry; cost effectiveness; detection limit; nanogold; nucleic acids;     Show all 7 Subjects
Abstract:
... In nucleic acid testing (NAT), gold nanoparticle (AuNP)-based lateral flow assays (LFAs) have received significant attention due to their cost-effectiveness, rapidity, and the ability to produce a simple colorimetric readout. However, the poor sensitivity of AuNP-based LFAs limits its widespread applications. Even though various efforts have been made to improve the assay sensitivity, most methods ...
DOI:
10.1021/acs.analchem.6b00195

15. Immunogenicity of parenterally delivered plant-derived small and medium surface antigens of hepatitis B virus

Author:
Fedorowicz-Strońska, Olga; Kapusta, Józef; Czyż, Marcin; Kaczmarek, Małgorzata; Pniewski, Tomasz
Source:
Plant cell reports 2016 v.35 no.5 pp. 1209-1212
ISSN:
0721-7714
Subject:
Hepatitis B virus,   etc   ; antibodies; cost effectiveness; hepatitis B antigens; immune response; immunoglobulin G; mice; vaccines;     Show all 8 Subjects
Abstract:
... KEY MESSAGE : Intramuscularly delivered plant-derived M-HBsAg was compared to S-HBsAg, and as a result elicited specific anti-preS2 antibodies and significantly higher titre of anti-HBs antibodies, together with IgG isotype profile indicating some Th1 polarisation, apart from the main Th2 response. HBV prevalence is still threatening, regardless of prevention programmes using vaccines containing S ...
DOI:
10.1007/s00299-016-1944-8
PubMed:
26905723
PubMed Central:
PMC4833783

16. Immune response to second vaccination series of hepatitis B virus among booster dose non-responders

Author:
Salama, Iman I.; Sami, Samia M.; Salama, Somaia I.; Rabah, Thanaa Mahmoud; El Etreby, Lobna Ahmed; Abdel Hamid, Amany T.; Elmosalami, Dalia; El Hariri, Hazem; Said, Zeinab N.
Source:
Vaccine 2016 v.34 no.16 pp. 1904-1908
ISSN:
0264-410X
Subject:
Hepatitis B virus,   etc   ; blood sampling; children; diabetes mellitus; fever; gender; immune response; vaccination; vaccines;     Show all 9 Subjects
Abstract:
... To evaluate the response to second vaccination series among post-booster sero-negative children who had previously received compulsory HBV vaccination.After given a booster dose to 1070 children, 103 of them failed to generate anamnestic response (anti-HBs <10IU/L). Only 91/103 children received additional two doses of recombinant HBV vaccine (i.e. 2nd vaccination series) after 1 and 6 months post ...
DOI:
10.1016/j.vaccine.2016.02.050

17. The role of long non-coding RNAs in hepatitis B virus-related hepatocellular carcinoma

Author:
Moyo, Buhle; Nicholson, Samantha A.; Arbuthnot, Patrick B.
Source:
Virus research 2016 v.212 pp. 103-113
ISSN:
0168-1702
Subject:
Hepatitis B virus,   etc   ; etiology; hepatoma; mortality; non-coding RNA; risk; virus replication;     Show all 7 Subjects
Abstract:
... Chronic infection with hepatitis B virus (HBV) is a major risk for development of hepatocellular carcinoma (HCC), which is the fifth most common cancer and a leading global cause of mortality. Long noncoding RNAs (lncRNAs) are regulators of complex biological processes and their functional disruption is implicated in the etiology of many cancers including HCC. Several lncRNAs have been shown to ha ...
DOI:
10.1016/j.virusres.2015.07.025

18. The cyclic GMP‐AMP synthetase–STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assembly

Author:
Dansako, Hiromichi; Ueda, Youki; Okumura, Nobuaki; Satoh, Shinya; Sugiyama, Masaya; Mizokami, Masashi; Ikeda, Masanori; Kato, Nobuyuki
Source:
The FEBS journal 2016 v.283 no.1 pp. 144-156
ISSN:
1742-464X
Subject:
Hepatitis B virus,   etc   ; DNA; DNA viruses; genes; hepatoma; humans; innate immunity; interferons; signal transduction; virus assembly;     Show all 10 Subjects
Abstract:
... During viral replication, the innate immune response is induced through the recognition of viral replication intermediates by host factor(s). One of these host factors, cyclic GMP‐AMP synthetase (cGAS), was recently reported to be involved in the recognition of viral DNA derived from DNA viruses. However, it is uncertain whether cGAS is involved in the recognition of hepatitis B virus (HBV), which ...
DOI:
10.1111/febs.13563

19. APOBEC3DE Antagonizes Hepatitis B Virus Restriction Factors APOBEC3F and APOBEC3G

Author:
Bouzidi, Mohamed S.; Caval, Vincent; Suspène, Rodolphe; Hallez, Camille; Pineau, Pascal; Wain-Hobson, Simon; Vartanian, Jean-Pierre
Source:
Journal of Molecular Biology 2016
ISSN:
0022-2836
Subject:
Hepatitis B virus,   etc   ; Gorilla; cytidine; enzymes; genes; loci; mutation; phenotype; single-stranded DNA;     Show all 9 Subjects
Abstract:
... The APOBEC3 locus consists of seven genes (A3A–A3C, A3DE, A3F–A3H) that encode DNA cytidine deaminases. These enzymes deaminate single-stranded DNA, the result being DNA peppered with CG →TA mutations preferentially in the context of 5′TpC with the exception of APOBEC3G (A3G), which prefers 5′CpC dinucleotides. Hepatitis B virus (HBV) DNA is vulnerable to genetic editing by APOBEC3 cytidine deamin ...
DOI:
10.1016/j.jmb.2016.05.022

20. A non-human hepadnaviral adjuvant for hepatitis C virus-based genetic vaccines

Author:
Levander, Sepideh; Sällberg, Matti; Ahlén, Gustaf; Frelin, Lars
Source:
Vaccine 2016 v.34 no.25 pp. 2821-2833
ISSN:
0264-410X
Subject:
Hepatitis B virus; Heron hepatitis B virus,   etc   ; CD4-positive T-lymphocytes; Hepatitis C virus; birds; genes; hepatitis B antigens; hepatitis C; humans; immunity; interferon-gamma; interleukin-2; mice; people; recombinant vaccines; vaccine adjuvants; vertebrate viruses;     Show all 17 Subjects
Abstract:
... Human hepatitis B virus (HBV) core antigen (HBcAg) can act as an adjuvant in hepatitis C virus (HCV)-based DNA vaccines. Since two billion people are, or have been, in contact with HBV, one may question the use of human HBV sequences as adjuvant. We herein evaluated non-human stork hepatitis B virus core gene-sequences from stork as DNA vaccine adjuvants. Full-length and fragmented stork HBcAg gen ...
DOI:
10.1016/j.vaccine.2016.04.030