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- Kondoh, Masuo, et al. Show all 11 Authors
- Biochemical and biophysical research communications 2016 v.477 no.1 pp. 91-95
- Hepatitis C virus; animal models; antineoplastic activity; chimerism; cytotoxicity; hepatocytes; human diseases; humans; immunoglobulin G; mice; monoclonal antibodies; mutants; neoplasm cells; neoplasms; pharmacokinetics; therapeutics; transmembrane proteins
- ... Claudin-1 (CLDN-1), an integral transmembrane protein, is an attractive target for drug absorption, prevention of infection, and cancer therapy. Previously, we generated mouse anti-CLDN-1 monoclonal antibodies (mAbs) and found that they enhanced epidermal absorption of a drug and prevented hepatitis C virus infection in human hepatocytes. Here, we investigated anti-tumor activity of a human–mouse ...