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- Nakayasu, Chihaya, et al. Show all 10 Authors
- Fish & shellfish immunology 2016 v.49 pp. 225-229
- Cyprinus carpio; carp; genes; interleukin-13; interleukin-4; kidneys; leukocytes; mammals; recombinant proteins; reverse transcriptase polymerase chain reaction; spleen
- ... Teleost IL-4/13B is a cytokine related to mammalian IL-4 and IL-13, of which hitherto the function had not been studied at the protein level. We identified an IL-4/13B gene in common carp (Cyprinus carpio) and expressed the recombinant protein (rcIL-4/13B). RcIL-4/13B was shown to stimulate proliferation of IgM+ B cells, because after four days of stimulation the IgM+ fraction of carp kidney and s ...