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- Tabaran, Flaviu, et al. Show all 6 Authors
- Journal of photochemistry and photobiology 2016 v.161 pp. 402-410
- DNA; DNA damage; Western blotting; adjuvants; apoptosis; cytoskeleton; defense mechanisms; melanin; melanocytes; melanogenesis; melanoma; oxidative stress; peroxidase; photosensitizing agents; pigmentation; porphyrins; spectroscopy; staining; therapeutics
- ... Melanoma, a cancer derived from melanocytes is very difficult to treat, especially in advanced cases. There are several encouraging studies of the efficacy of photodynamic therapy (PDT) in melanoma. However, PDT has to overcome the main defense mechanisms like: defects in the apoptotic pathways, pigmentation, sequestration of the photosensitisers (PS) inside melanosomes and increased oxidative str ...