You searched for:
Publication year rev
7985-2015
Remove constraint Publication year rev: 7985-2015
Subject
amino acids
Remove constraint Subject: amino acids
Subject term
antagonists
Remove constraint Subject term: antagonists
PubAg
Main content area
Limit your search
Search
13 Search Results
1 - 13 of 13
Search Results
- Author:
- Guilin R. Ren; Jonas Folke; Frank Hauser; Shizhong Li; Cornelis J.P. Grimmelikhuijzen
- Source:
- Biochemical and biophysical research communications 2015 v.462 pp. 358-364
- ISSN:
- 0006-291X
- Subject:
- Drosophila melanogaster; G-protein coupled receptors; acetylcholine; agonists; amino acids; antagonists; arthropods; atropine; cholinergic receptors; genome; mammals; pharmacology
- Abstract:
- ... Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors (GPCRs) that are activated by the agonists acetylcholine and muscarine and blocked by several antagonists, among them atropine. In mammals five mAChRs (m1-m5) exist of which m1, m3, and m5 are coupled to members of the Gq/11 family and m2 and m4 to members of the Gi/0 family. We have recently shown that Drosophila melanoga ...
- DOI:
- 10.1016/j.bbrc.2015.04.141
- https://doi.org/10.1016/j.bbrc.2015.04.141
- Author:
- Byung Mun Park; Seung Ah Cha; Bo Ram Han; Suhn Hee Kim
- Source:
- Peptides 2015 v.63 pp. 30-37
- ISSN:
- 0196-9781
- Subject:
- amino acids; angiotensin II; angiotensin III; antagonists; atrial natriuretic peptide; dose response; insulin; mammals; membrane alanyl aminopeptidase; non-specific serine/threonine protein kinase; phosphatidylinositol 3-kinase; rapamycin; secretion; signal transduction
- Abstract:
- ... Angiotensin IV (Ang IV) is formed by aminopeptidase N (APN) from angiotensin III (Ang III) by removing the first N-terminal amino acid. Previouslt, we reported that angiotensin II (Ang II) inhibits atrial natriuretic peptide (ANP) secretion via angiotensin II type 1 receptor (AT1R). In contrast, angiotensin-(1–7) [Ang-(1–7)] and Ang III stimulate ANP secretion via Mas receptor (Mas R) and angioten ...
- DOI:
- 10.1016/j.peptides.2014.10.016
- https://doi.org/10.1016/j.peptides.2014.10.016
- Author:
- Sonia Carta; Federica Penco; Rosa Lavieri; Alberto Martini; Charles Anthony Dinarello; Marco Gattorno; Anna Rubartelli
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.9 pp. 2835-2840
- ISSN:
- 0027-8424
- Subject:
- adenosine triphosphate; amino acids; antagonists; antioxidants; interleukin-18; interleukin-1beta; monocytes; mutation; oxidative stress; pathophysiology; patients; purinergic receptors; secretion; stress tolerance
- Abstract:
- ... Cell stress is implicated in triggering bouts of systemic inflammation in patients with autoinflammatory disorders. Blood monocytes from patients affected by NLRP3-mediated cryopyrin-associated periodic syndromes (CAPS) release greater amounts of IL-1β than monocytes from unaffected subjects. Here we show that stress lowers the threshold of activation; blood monocytes from CAPS patients maintain t ...
- DOI:
- 10.1073/pnas.1424741112
- PubMed:
- 25730877
- PubMed Central:
- PMC4352822
- https://doi.org/10.1073/pnas.1424741112
- Author:
- Xinbing Han; Yan Feng; Xinhua Chen; Craig Gerard; William A. Boisvert
- Source:
- FEBS Open Bio 2015 v.5 pp. 182-190
- ISSN:
- 2211-5463
- Subject:
- CXCR1 receptor; CXCR2 receptor; amino acids; antagonists; humans; innate immunity; interleukin-8; ligands; mutants; pathogens; point mutation
- Abstract:
- ... CXCR1, a receptor for interleukin-8 (IL-8), plays an important role in defending against pathogen invasion during neutrophil-mediated innate immune response. Human CXCR1 is a G protein-coupled receptor (GPCR) with its characteristic seven transmembrane domains (TMs). Functional and structural analyses of several GPCRs have revealed that conserved residues on TM3 (including the highly conserved Asp ...
- DOI:
- 10.1016/j.fob.2015.03.001
- PubMed:
- 25834784
- PubMed Central:
- PMC4372616
- https://doi.org/10.1016/j.fob.2015.03.001
- Author:
- Karpinsky-Semper Darla; Tayou Junior; Levay Konstantin; Schuchardt Brett J.; Bhat Vikas; Volmar Claude-Henry; Farooq Amjad; Slepak Vladlen Z.
- Source:
- Biochemistry 2015 v.54 no.4 pp. 1077-1088
- ISSN:
- 1520-4995
- Subject:
- amino acids; antagonists; atropine; calcium; calcium signaling; circular dichroism spectroscopy; mutants; plasma membrane; regulatory proteins
- Abstract:
- ... The muscarinic M3 receptor (M3R) is a Gq-coupled receptor and is known to interact with many intracellular regulatory proteins. One of these molecules is Gβ5-RGS7, the permanently associated heterodimer of G protein β-subunit Gβ5 and RGS7, a regulator of G protein signaling. Gβ5-RGS7 can attenuate M3R-stimulated release of Ca²⁺ from intracellular stores or enhance the influx of Ca²⁺ across the pla ...
- DOI:
- 10.1021/bi500980d
- PubMed:
- 25551629
- PubMed Central:
- PMC4318586
- https://doi.org/10.1021/bi500980d
- Author:
- Joubert Banjop Kharlyngdoh; Ajay Pradhan; Solomon Asnake; Anders Walstad; Per Ivarsson; Per-Erik Olsson
- Source:
- Environment international 2015 v.74 pp. 60-70
- ISSN:
- 0160-4120
- Subject:
- Western blotting; amino acids; androgen receptors; antagonists; antigens; blood-brain barrier; blubber; brain; cell membranes; drugs; dust; endocrine-disrupting chemicals; flame retardants; gene expression regulation; genes; human health; humans; models; neurons; neurotoxicity; prostatic neoplasms; risk reduction; seals; transcription (genetics); wildlife
- Abstract:
- ... Brominated flame-retardants (BFRs) are used in industrial products to reduce the risk of fire. However, their continuous release into the environment is a concern as they are often persistent, bioaccumulating and toxic. Information on the impact these compounds have on human health and wildlife is limited and only a few of them have been identified to disrupt hormone receptor functions. In the pre ...
- DOI:
- 10.1016/j.envint.2014.09.002
- https://doi.org/10.1016/j.envint.2014.09.002
- Author:
- Moniek Van Geem; Jeffrey A. Harvey; Anne Marie Cortesero; Ciska E. Raaijmakers; Rieta Gols
- Source:
- Journal of chemical ecology 2015 v.41 no.8 pp. 696-707
- ISSN:
- 0098-0331
- Subject:
- Brassica oleracea var. oleracea; Delia radicum; amino acids; antagonists; cabbage; coasts; genetic variation; glucosinolates; herbivores; nutrients; plant biochemistry; secondary metabolites; sugars; toxicity; United Kingdom
- Abstract:
- ... Plants are attacked by both above- and belowground herbivores. Toxic secondary compounds are part of the chemical defense arsenal of plants against a range of antagonists, and are subject to genetic variation. Plants also produce primary metabolites (amino acids, nutrients, sugars) that function as essential compounds for growth and survival. Wild cabbage populations growing on the Dorset coast of ...
- DOI:
- 10.1007/s10886-015-0605-7
- PubMed:
- 26271671
- PubMed Central:
- PMC4568014
- https://doi.org/10.1007/s10886-015-0605-7
8. Ketamine modulates TRH and TRH-like peptide turnover in brain and peripheral tissues of male rats
- Author:
- A. Eugene Pekary; Albert Sattin; Robert L. Lloyd
- Source:
- Peptides 2015 v.69 pp. 66-76
- ISSN:
- 0196-9781
- Subject:
- Alzheimer disease; Parkinson disease; adverse effects; amino acids; amygdala; antagonists; antidepressants; anxiety; biosynthesis; cortex; epididymis; epilepsy; frontal lobe; health services; hippocampus; hypothalamus; ketamine; laboratory animals; males; medulla oblongata; pancreas; patients; rats; risk; testes; therapeutics; thyrotropin-releasing hormone
- Abstract:
- ... Major depression is the largest single healthcare burden with treatments of slow onset and often limited efficacy. Ketamine, a NMDA antagonist used extensively as a pediatric and veterinary anesthetic, has recently been shown to be a rapid acting antidepressant, making it a potential lifesaver for suicidal patients. Side effects and risk of abuse limit the chronic use of ketamine. More complete un ...
- DOI:
- 10.1016/j.peptides.2015.04.003
- https://doi.org/10.1016/j.peptides.2015.04.003
- Author:
- Shengwei Luo; Youhua Huang; Fuxing Xie; Xiaohong Huang; Yuan Liu; Weina Wang; Qiwei Qin
- Source:
- Fish & shellfish immunology 2015 v.43 no.2 pp. 310-324
- ISSN:
- 1050-4648
- Subject:
- 3' untranslated regions; 5' untranslated regions; DNA damage; Epinephelus coioides; Vibrio alginolyticus; amino acid sequences; amino acids; antagonists; genes; grouper; heart; immune response; inflammation; interleukin-6; intestines; isoelectric point; kidneys; lipid peroxidation; liver; molecular cloning; molecular weight; muscles; open reading frames; peroxisome proliferator-activated receptors; quantitative polymerase chain reaction; spleen; tissues
- Abstract:
- ... PPAR gamma was a key nuclear receptor, playing an important role in the immune defense and the anti-inflammatory mechanism. In this study, the full-length PPAR gamma (EcPPAR gamma) was obtained, containing a 5′UTR of 133 bp, an ORF of 1602 bp and a 3′UTR of 26 bp besides the poly (A) tail. The EcPPAR gamma gene encoded a protein of 533 amino acids with an estimated molecular mass of 60.02 KDa and ...
- DOI:
- 10.1016/j.fsi.2015.01.003
- https://doi.org/10.1016/j.fsi.2015.01.003
- Author:
- Zhenghua Ren; Lei Wang; Mengying Qin; Yuwen You; Wuguang Pan; Liang Zhou; Dandan Sun; Anlong Xu
- Source:
- Toxicon 2015 v.96 pp. 57-67
- ISSN:
- 0041-0101
- Subject:
- Conus; amino acids; analgesic effect; animal models; antagonists; cholinergic receptors; complementary DNA; conotoxins; drug abuse; fluorescent dyes; gene expression; messenger RNA; mice; mitogen-activated protein kinase; morphine; neurons; pain; phosphorylation; rats; spinal cord; South China Sea
- Abstract:
- ... Conotoxin lt14a is a small peptide consisting of 13 amino acids. It was originally identified from the cDNA of Conus litteratus in the South China Sea. Previous reports showed lt14a exhibited antinociceptive activity using a hot plate-induced pain mouse model and acted as an antagonist of neuronal nicotinic acetylcholine receptors. We confirmed that conotoxin lt14a administration resulted in antin ...
- DOI:
- 10.1016/j.toxicon.2015.01.013
- https://doi.org/10.1016/j.toxicon.2015.01.013
- Author:
- D. Sivaramakrishna; S. Thirupathi Reddy; Thejaswi Nagaraju; Musti J. Swamy
- Source:
- Colloids and Surfaces A: Physicochemical and Engineering Aspects 2015 v.471 pp. 108-116
- ISSN:
- 0927-7757
- Subject:
- X-ray diffraction; agonists; amino acids; antagonists; brain; calorimetry; enthalpy; fluorescence emission spectroscopy; least squares; mammals; monitoring; phase transition; receptors; spectral analysis; temperature; tissues
- Abstract:
- ... N-Acyl conjugates of amino acids, found in mammalian brain and other tissues, act as agonists and antagonists to receptors. In the present study, we synthesized and investigated the self-assembly, thermotropic phase transitions, and supramolecular organization of a homologous series of N-acyl-l-alanines (NAAs) containing saturated acyl chains (n=8–20). The critical micellar concentrations (CMCs) o ...
- DOI:
- 10.1016/j.colsurfa.2015.02.025
- https://doi.org/10.1016/j.colsurfa.2015.02.025
12. An antenna-biased carboxylesterase is specifically active to plant volatiles in Spodoptera exigua
- Author:
- Peng He; Ya-Nan Zhang; Ke Yang; Zhao-Qun Li; Shuang-Lin Dong
- Source:
- Pesticide biochemistry and physiology 2015 v.123 pp. 93-100
- ISSN:
- 0048-3575
- Subject:
- Spodoptera exigua; adults; amino acids; antagonists; carbon; carboxylesterase; cholinesterase; fluorescence in situ hybridization; genes; host plants; insect pests; lymph; messenger RNA; odor compounds; odorant receptors; pH; pesticides; quantitative polymerase chain reaction; sensilla; sex pheromones
- Abstract:
- ... Odorant-degrading enzymes (ODEs) in sensillar lymph are proposed to play important roles in the maintenance of the sensitivity of the olfactory sensilla, by timely degrading the odorants that have already fulfilled the activation of the odorant receptor (OR). Here we reported the cloning and characterization of an ODE gene (SexiCXE10) from the polyphagous insect pest Spodoptera exigua. SexiCXE10 i ...
- DOI:
- 10.1016/j.pestbp.2015.03.009
- https://doi.org/10.1016/j.pestbp.2015.03.009
- Author:
- Zhaoqun Liu; Zhi Zhou; Lingling Wang; Shuai Jiang; Weilin Wang; Ran Zhang; Linsheng Song
- Source:
- Developmental and comparative immunology 2015 v.49 no.2 pp. 217-224
- ISSN:
- 0145-305X
- Subject:
- Crassostrea gigas; G-protein coupled receptors; amino acids; antagonists; antibacterial properties; calcium; complementary DNA; cyclic AMP; gills; hemocytes; hepatopancreas; homeostasis; immune response; immunocytes; immunomodulation; kidneys; ligands; messenger RNA; muscles; narcotics; oysters; pathogens; second messengers
- Abstract:
- ... Opioid receptors (OR) are a group of G protein-coupled receptors with opioids as ligands, which play an important role in triggering the second messengers to modulate immune response in vertebrate immunocytes. In the present study, the full length cDNA of a homologue of δ-opioid receptor (DOR) for [Met5]-enkaphalin was cloned from oyster Crassostrea gigas (designated as CgDOR), which was 1104 bp e ...
- DOI:
- 10.1016/j.dci.2014.11.017
- https://doi.org/10.1016/j.dci.2014.11.017